#version: 0.2 Ġ t Ġ a i n r e h e Ġ o t i Ġt he o n Ġ s e n Ġ c e d e r Ġo f Ġ in Ġ p Ġ w a l Ġ d a t Ġa n e s Ġ b i t Ġ m Ġ f a s i s ti on o r i c Ġan d a n r o Ġ e Ġ re Ġ l a r en t in g Ġ n Ġt o e c e l Ġt h u s a tion u l Ġ g Ġ h l e i d e re Ġ ( it h u r o l Ġw ith a c e t l y v e o m o s Ġw as u n Ġ v i g Ġs t c e a ti i m Ġ r t er Ġ is i f u c Ġa c Ġf or i l Ġ 1 o t u t Ġc on Ġw ere u m re s at ed a m o d Ġb y ec t Ġp ro Ġa s Ġo n o w Ġa l el l s t Ġb e ent s Ġe x e m Ġth at it y a in Ġre s i on in e i r as e a b ti c an t Ġc om Ġa t a g s e e v at e a p Ġs u Ġc ell Ġo r ro m u re a d t he a y u d Ġp ati ic al Ġ 2 t h Ġf rom f f t s i v o p q u i b Ġc h Ġd is es s Ġp er ti v o c Ġcom p m ent Ġw h Ġa re Ġpati ents o g d uc Ġa d u p Ġin c un d Ġ he e p Ġg en Ġp re o us Ġ us es t Ġs p Ġth is i z if ic Ġs h ig h ti ve y l Ġ 3 p p Ġn ot Ġs y i a Ġp l ig n i es Ġe ff or m Ġst ud i p Ġcell s o re re as Ġth an Ġ it Ġthe se or t res s en ce tion s Ġs e ev el ar y Ġd i er s Ġg ro Ġ i Ġex p Ġ en Ġd e Ġin f ic h re at Ġc l he r s is if f en s Ġa b a re g e ac t Ġw e Ġd iff Ġres p Ġsu b ation s Ġac tiv i al i ed Ġb et Ġa f Ġo b u g p h ul ar Ġ k ere n Ġ 5 d ing Ġaf ter Ġs ign Ġwh ich 0 0 Ġh a Ġst r Ġ im Ġ 4 e ar el y Ġres ul Ġc o Ġ y on e ) . Ġin d Ġp res Ġf o Ġa r Ġ 0 Ġa pp Ġeff ect et h Ġg r v er Ġin t w e t ain os e Ġm e the r l o p t Ġe in Ġd et Ġa m Ġt r Ġn e er v c h Ġw he Ġdiff eren Ġ un an ce re n Ġas s Ġsign ific Ġre c Ġt w Ġsh ow i tion al ly er m st r Ġre p Ġgro up Ġ ic duc ed id e t ed Ġsignific ant Ġb ut Ġr at ot h ati ve Ġha ve ) , an d l ow i ti n a igh t or s ab le Ġc or Ġs er an c Ġd ur u e Ġn o re e Ġre l Ġl og Ġe v ag e Ġim p Ġs ur Ġtw o h ib ect ed Ġl evel reas ed g g Ġactiv ity we en on g Ġbe en as es Ġbet ween i ve Ġl e Ġresp on u b or y Ġh ad a k en ti Ġ 6 en d en c Ġre g Ġs c s o Ġb oth y m Ġe l Ġresul ts Ġsp ec orm al Ġ - Ġc a Ġal l un c Ġdur ing Ġin v al l Ġt reat b r an g ti m Ġp h ec tion Ġh as p er Ġm ay t r Ġd ec Ġa g Ġin hib Ġp r m a in ed iz ed ar i Ġsy n ul ation il l Ġm ore Ġfo und Ġm ed ev er in ding Ġm eth Ġpl as Ġtreat ment Ġal so Ġ x v i s erv Ġo ther os t c l Ġac id Ġp ar Ġsu gg Ġl ow o ut an e re ase Ġon e Ġ1 0 Ġf ol Ġstud y are d ul t Ġthe re as s i um Ġ es Ġh igh Ġv al ug h p l ac h u res ul d Ġ + ion s Ġs im al y Ġob serv Ġo c is s Ġc an ce pt c ur Ġl ess in al Ġb od Ġfor m Ġpres ent ap h Ġ 7 Ġdis e Ġm od Ġt im at ing Ġthe ir il ity Ġb i Ġ ro lo od Ġd es Ġn ormal Ġ und ere d Ġinc reased / - Ġon ly re d is t l ic Ġb lood evel op Ġsy st Ġind ic ac ter oc i Ġs ec Ġwhe n Ġd evelop ay s o ur o x Ġme as Ġv ari Ġn on Ġfol low Ġ id Ġc ases Ġ+ /- Ġd r Ġm al Ġlevel s Ġs am Ġcomp le al s y s tain ed Ġd ep Ġ 8 Ġsugg est ag n Ġsyst em he m Ġund er c r Ġcl in t al er y unc tion c t uc le os is Ġm a Ġf r z ym Ġinhib it Ġh um Ġus ed Ġt est Ġa tion Ġs uc c ess Ġf act Ġdet erm Ġp os i x Ġdise ase Ġmeth od Ġc r it e i tive Ġobserv ed as t ear s Ġs tim duc tion Ġshow ed Ġm an Ġe p Ġex am u es Ġan aly l u Ġhum an Ġb as Ġcon s is m d e Ġcon t Ġm em Ġ up m on Ġn ucle Ġlog ical Ġclin ical in ation Ġus ing ph a u al at es Ġsignificant ly at er ar d Ġit s Ġth ree Ġ qu Ġr ate Ġeffect s d er Ġexp er iz ation m o Ġad d ress ion Ġre ac Ġm on u tion Ġ 9 Ġ1 9 Ġch ang Ġinc rease Ġm g enc y Ġmeas ure Ġgen e he d il d Ġint o Ġm o r ap uc t Ġdifferen t Ġde f ec tive Ġel ect ic i ac e at a re l Ġen zym Ġb r at ory Ġser um Ġass oci Ġper i i le Ġd em Ġoc cur Ġde g Ġcomp ared ati c il ar ic e Ġthe rap Ġf unction m ents Ġ = Ġo ut Ġh ow ect s Ġth ose Ġac c re ated ec h Ġt iss Ġstud ied Ġus e es ti t ing Ġtim e Ġin s a il us ion Ġrespon se Ġrat s Ġm ost Ġchang es k ed Ġp ot Ġm y Ġo ver Ġ j um b Ġin j ut e Ġv ir an ge Ġm ar on str Ġsu pp Ġsim ilar ter n on d o un iti es Ġca us Ġdi agn Ġb l Ġgr aph Ġdis c Ġplas ma Ġmem br ec tiv Ġwh o v ed Ġd ata e x Ġa ff Ġm us et r Ġl oc Ġh ig er g Ġre cept e w Ġhow ever Ġm in Ġd id Ġw ell Ġspec ific Ġg reat at ure t e d i Ġbod y Ġstud ies esti g ' s Ġa ge Ġch ar Ġgro w ol d a v Ġrep ort Ġg l Ġperi od Ġinv estig Ġdem onstr Ġ1 2 Ġe m end ent ti l Ġd na o id Ġl y o und Ġsub j it ro Ġpro g ar t ant s Ġme an Ġpati ent Ġo x Ġd ays Ġgroup s Ġpro b k s Ġf ir Ġy ears or d Ġdr ug Ġ . s p Ġsyn the he n Ġn umb Ġar ter f ore Ġis ol Ġs ens Ġanaly sis Ġb le Ġpres ence Ġal pha Ġd o Ġc ol Ġadd ition Ġstr uct Ġp ress Ġexper im i k Ġs ol Ġc ult cr ib re qu Ġl iv n e it her Ġfir st ro p Ġch ild Ġb inding o ugh ul in Ġob tained tic al Ġinc l i i Ġhig her Ġchar acter ol og Ġgen er l es Ġa tions Ġbet a Ġ u Ġs m ectiv ely Ġse qu Ġassoci ated al u Ġco uld it s 5 0 ul ated Ġl ar t en Ġan im Ġsuc h Ġtherap y ad e Ġsur g o uld c es Ġev alu Ġe ar ain s Ġdes crib s es f t Ġf requ ech an Ġre m Ġcor rel Ġ ur Ġs el Ġe ach Ġab s os ed if ied Ġd ose ous ly Ġto tal g en om y Ġtiss ue Ġincl ud Ġc hem f ul i or Ġm echan Ġinv ol Ġhe m Ġgrow th Ġwith in it al Ġne w Ġb ol t y Ġenzym e Ġ2 0 Ġnumb er is e Ġhe p Ġc at Ġcon f Ġf inding Ġpro v re ct 1 0 n al Ġl ab Ġc ap Ġm m Ġp at Ġex t % ) Ġmembr ane ar r Ġb ec Ġp ep Ġ [ Ġgreat er Ġthe y Ġpr im Ġto x Ġp o Ġd el Ġhe al Ġcell ular ical ly Ġmon th ep endent Ġsam e m s Ġliv er us s Ġfo ur iv ed Ġre le Ġsm all p or k g ro s enti f Ġf er enti al Ġf ur Ġein s ab ility Ġl ong t in Ġpress ure qu i Ġfollow ing Ġs it in es Ġimp ort Ġpar tic Ġm ut k in Ġe ither Ġsubj ects - - Ġs ev Ġapp ro ro ugh Ġo p Ġre f ti s c ed i ly o b Ġt reated Ġc ase ent ly Ġsec ond Ġvir us Ġwe e Ġwh ile Ġf e Ġsy m Ġ er Ġwith out m ed y p Ġm ain Ġl es Ġcon tain ak e c o Ġp ur Ġdevelop ment Ġdec reased em ent am ine on s Ġchild ren Ġdisc uss Ġpre vi Ġresp ectively Ġid entif ati v o v tiv ity iz e Ġ " Ġlow er ent al Ġt ic ti de Ġ1 5 Ġpro cess Ġm ice Ġv en Ġpro l Ġab out c le Ġc ur Ġre duced are n Ġmeasure d Ġheal th us e Ġanim als Ġth rough Ġ if Ġcons id y st Ġt ens Ġe qu y r Ġac tion Ġmechan ism Ġmod el c ent Ġv ol Ġisol ated in d Ġcomple x Ġp ul Ġd ue Ġ ig Ġpre d Ġfact or Ġs ing Ġin duced iv en Ġre ve es ts iv id in s Ġbod ies Ġfinding s Ġin iti Ġreport ed Ġdeterm ined Ġe le tr ib ur al Ġmonth s j or Ġrecept or Ġexam ined Ġval ues it ed Ġpre v ro ph am s Ġo per Ġ3 0 Ġl ip Ġma jor Ġs ever Ġev id Ġgraph y a f h a Ġw om p le Ġre qui Ġch ol Ġinc reas Ġpat tern Ġ ir Ġsing le Ġcom b n ow Ġmed i og en Ġcon cl Ġsec re Ġdescrib ed Ġ est Ġm ol c om Ġv itro Ġ1 4 Ġper f Ġform ation 00 0 ti t Ġreve al Ġshow n th ough y n Ġdifferen ces un g Ġdiagn osis pt om Ġc le Ġt em Ġstr ation Ġdemonstr ated Ġdiscuss ed di tions Ġcon ditions Ġinf ection Ġan a Ġm uc Ġinf lu Ġc anc Ġex c Ġmus cle Ġro le p tion Ġag ain al ity Ġfact ors ib le Ġn g ress ed Ġbe fore Ġsur f k ing Ġass ess Ġo ur Ġear ly Ġcon sis Ġpro duced Ġc d Ġwe ight Ġpro ced Ġsc op Ġsh ould Ġ1 1 Ġt erm l ed Ġbr ain Ġreg ion Ġgen es ud e ) - Ġexp ression Ġp op Ġcult ure Ġsynthe sis is tic Ġc ir Ġimp ro Ġ2 4 Ġfr ac Ġam ong Ġal though Ġpro duc lo b iv al Ġac tive r i ren t Ġr is Ġf em ain ed Ġn ec Ġrel ated Ġe c ater al Ġb acter it er Ġre nal o ver Ġdevelop ed Ġdec rease in duced Ġcol l Ġpos itive a z Ġvari ous ab ly eth yl Ġwom en Ġstim ulation an n Ġac ute re es Ġd ay Ġcl ass is hed Ġw or Ġf low Ġre ce Ġ5 0 os p es ter Ġreveal ed Ġ z ot her ag es Ġhe art Ġn s Ġwhe reas m l Ġan y Ġinhib ition Ġimport ant Ġ1 3 Ġstim ul Ġagain st i el Ġelect r er c Ġdeg rees Ġa v Ġs in Ġth us at h os es r h an s Ġcanc er em ia Ġle u Ġinvestig ated Ġs al Ġloc al Ġt ub Ġl s Ġf ail Ġ , Ġl im Ġsym ptom Ġg iven Ġp e Ġlar ge Ġfur ther g n n ormal ain ing Ġprim ary Ġa p re c our s Ġs o a use Ġm et Ġevid ence x i Ġv is 1 2 Ġdifferen ti Ġindic ate Ġc ere am p Ġind ivid Ġwee ks Ġcl on Ġrespon ses ane ous u ce Ġsur v Ġep i Ġsever al Ġk now Ġass ay a ir iel d Ġr ap el et Ġs ite oc k Ġrele ase Ġmy o z ed Ġlip id Ġi i v ers Ġres ist Ġm en Ġcom mon Ġdet ected Ġplas m Ġb one Ġm r Ġsurf ace Ġpar t Ġtox ic res p Ġ1 6 Ġdis trib Ġdi rect Ġam oun h ip ter m Ġ1 8 n ess Ġpresent ed y ro er ation Ġch ange Ġlog y iti s Ġad en Ġrel ations ativ ely se qu am ic Ġcaus ed Ġf l Ġh orm Ġp le Ġpro p Ġsam pl Ġles ions Ġres id ec ular c in e f ve ment Ġd er Ġcomp on Ġp hen Ġris k ic k Ġreac tion Ġoccur red Ġcir c al e Ġm ade g r Ġle ft ik e d ependent Ġs us ac k Ġsit es e tic Ġrap id Ġm um ec tions Ġc arr Ġl ung Ġgen ic Ġen h Ġr ati Ġc ent Ġb en Ġab normal Ġs ix Ġic ular Ġf ive Ġbe ha Ġm at Ġper cent g et Ġinhibit ed r ic os ure Ġv ery is h Ġbec ause Ġf at ti es d a Ġse en Ġlog ic Ġre duction c er Ġs is Ġdi et Ġpro duction orm ation Ġv i en g mon ary Ġmar ked m e Ġ ion o tic Ġrelations hip Ġh osp Ġl ine Ġins ulin Ġph ase Ġbeha vi t o if e he s ol ar ap p Ġi um Ġf lu Ġf am Ġsequ ence Ġpot ential Ġc are lic ation ut ed Ġst er Ġcont in 0 5 Ġtim es u ally Ġco un Ġ1 00 Ġth yro g ative Ġpre gn Ġp ort lic ations Ġcharacter istic a e Ġpul monary Ġ2 5 or b Ġsev ere Ġele v Ġdifferen ce vi ew Ġprevi ously o od Ġmol ecular ut h Ġf ree os s Ġmethod s Ġstr ains Ġsurg ery Ġpro per ub le anc es in t i tivity Ġrat es Ġn al ab l Ġcont ent Ġresul t Ġs l Ġle ad Ġin e am in v ing Ġleu k Ġph ys Ġ1 7 er ve Ġeff ective Ġapp ear om a Ġtest ed m in enc es ific ation in c Ġspec ies ros s aren t olog ical Ġstruct ure Ġn m Ġf il Ġre view ro w Ġ ed Ġfrequ ency tion al Ġinj ection id ine Ġat t Ġr na at or Ġsampl es ol ic Ġ il Ġvol um Ġen d in ary Ġidentif ied Ġne ed a x Ġg u in ant og n Ġsuggest ed ici ent i an ici ency 1 9 sp ec % , Ġcontain ing Ġ ent od ium Ġpep tide Ġfollow ed Ġv iv Ġrecept ors Ġox y im ens Ġn or Ġo l Ġp ap Ġgener al Ġd oses Ġn a Ġexp l Ġactiv ation Ġmed ium Ġr ab Ġcomp ar Ġsh ort 1 4 Ġn ce Ġappro xi Ġdeterm ine Ġviv o Ġbe ing Ġpop ulation t a Ġh al Ġper ip Ġexp osure t reated Ġexperim ents Ġval ue ous e Ġcle ar ep h Ġtem per l i o le Ġprob le Ġare a Ġ4 0 Ġes c anc y Ġa uth Ġs kin og r re g Ġsub st Ġgen s Ġmo le anc ed Ġh ours 0 1 Ġse x n ing Ġhosp ital Ġbas ed Ġsymptom s t ent o res Ġest abl Ġdistrib ution Ġsurg ical et y Ġn at Ġad v Ġconf ir or ding Ġ ill Ġinvol ved Ġac et Ġpar ti Ġrab b Ġe th Ġre d Ġsens itivity Ġcomp ound spec ific Ġmal e med i Ġ19 8 Ġindic ated Ġrec om Ġpartic ular Ġl oss Ġor der Ġac h erg ic Ġsin ce Ġsupp ort Ġh y an es Ġr ange Ġdis t Ġinclud ing Ġperip her Ġelect ro Ġven ous el s Ġacid s Ġcor on Ġt e Ġm er op h Ġdrug s c ell Ġint est Ġf et en ing Ġs ize f old tic ally Ġpred ic Ġarter y Ġtens ion Ġrati o Ġfrac tion ul f Ġcorrel ation Ġst and Ġsurv ival Ġs odium an ol Ġchem ical Ġd a v al Ġproced ure Ġa ver Ġle ast Ġm etr Ġgr an Ġn erve Ġsecre tion Ġflu id Ġman y Ġc t Ġelectr on l er Ġcon d is ed Ġcontin u Ġco ur Ġ ery Ġresul ted Ġor ig r al ic ation Ġal ter Ġox id Ġre mo Ġan t Ġiniti al . , ud ed Ġpl at Ġl ight Ġc al s f v es Ġwor k c a Ġinc ub 2 5 Ġre st Ġ6 0 Ġp ig am ma Ġvolum e end ed ur n Ġis o is on t ake ul l Ġcom m p r s h Ġx y Ġ ide Ġstand ard ag en op er Ġdi ab Ġre t Ġthyro id Ġinj ur 2 0 Ġgr ams Ġknow n p s Ġad ult Ġ ul Ġrep res Ġw ill ag on Ġdo es Ġm ass Ġcoron ary Ġr y l am Ġexperim ental Ġevalu ated Ġs ide Ġrequi red Ġm it Ġ ib Ġfr ag w ard d s at ures Ġw ater os tic Ġactiv ities Ġt ion g f Ġ ve Ġpur ified Ġl at Ġwhe ther Ġthere fore Ġperipher al Ġthe n Ġb il Ġresist ance br al Ġapp arent ( - 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ti Ġnucle i Ġplace bo Ġf in Ġgen ous Ġob struc Ġn eph Ġinhibit ors Ġfer ase Ġpreval ence cept or es is Ġcon sequ Ġbi le Ġseg ment Ġ2 9 Ġgr aft Ġ3 6 Ġsub stit ad ren Ġfrag ment Ġresp ect Ġappear ance Ġrabb its Ġmeasure ment pos itive Ġm s ann ing Ġn ature Ġl ac Ġdi ed Ġgr af ens itive er at Ġab le Ġchemotherap y Ġb ility Ġir on Ġcontinu ous Ġtic s Ġunderw ent le ment Ġsh if Ġpro xim Ġar tic Ġal tered term inal Ġr h Ġlong er Ġpot ent Ġfam il m g Ġf usion c g Ġclinical ly Ġslight ly Ġne oplas Ġeffic acy Ġs af Ġgr ad Ġassess ment Ġemplo y Ġint ake g ed Ġtem por m y Ġpancre atic Ġsus cepti Ġf ast Ġben z Ġfail ed Ġf unctions Ġdegr ad Ġpro mo Ġdiab etes tern al Ġalb umin Ġinfarc tion ac tive Ġunder go Ġin activ Ġsp l Ġalter ations Ġdes pite Ġcor d medi ated Ġdep ression Ġincorpor ation Ġevalu ate 2 2 g es Ġn ut Ġdef in s a ly ing hen yl cl es Ġcrip tion Ġm igr chol ine Ġvari ation Ġ3 3 is ing Ġperiod s Ġlipid s Ġtra um Ġvari ety Ġat e Ġlar ger Ġl ys Ġproble m Ġun it Ġmel an Ġag ed Ġhep atitis 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m t s ub Ġcri tical de hy Ġasp ir Ġben ign Ġseg ments Ġi od Ġprev ented il ibr iv es if y Ġw ound y cin Ġbehavi our Ġplatelet s t ation Ġoxid ation Ġconcl usion Ġp i Ġreac hed Ġy et Ġs qu Ġa round Ġ3 9 Ġm urine Ġth in Ġm ak ox ic em i Ġbre ak Ġhep arin n itro Ġreg ulatory Ġimp aired Ġsupp ress Ġeth yl Ġref erence Ġcap s Ġth i Ġgener ated Ġj oint Ġconsider able Ġpo ol Ġcomp eti Ġcap able Ġdep le Ġcran ial Ġclon es m an anc ies Ġaltern ative Ġrecomm ended ect in Ġ5 5 Ġcur ve ell ar iven ess Ġer ol Ġsol utions Ġmid dle lin ked Ġty rosine ch ing Ġhybrid ization Ġech o Ġinf il ass ociated Ġc ytic Ġelectr ical Ġsch ool es tic Ġlocal ization Ġey es d es Ġinvestig ations Ġy e Ġpro j Ġg a Ġib ute Ġun treated Ġd uc y thm Ġfil am n p Ġsh ock Ġpredic ted Ġnucle ot Ġprob e Ġtrial s Ġana esthe Ġ7 2 op e Ġsc ores us ing Ġsupp ressed Ġren in th ree Ġad ren Ġs hed Ġobstruc tion Ġam b Ġmark er ic in Ġd ivided Ġal ve rh ythm b enz Ġrec overed Ġcent er Ġfet us Ġpredic t g amma ti zed Ġrecogn ition Ġneon 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lets rim al Ġmong rel Ġb ank Ġh app Ġcon val Ġam itr Ġmas king Ġalk ylation Ġsatisf actorily Ġvap or Ġwor th Ġovid uct Ġgr and Ġev ening Ġpur ulent Ġov ulatory Ġquestion ed Ġpi eces Ġcp k Ġenol pyruvate d ays Ġinf lamed Ġcat h Ġmas k Ġanc est 1 15 l f Ġp ell Ġsl opes Ġtolu ene c ourse l ived ol um ac ron Ġsh ad Ġsh apes Ġoxid oreductase Ġuns elected Ġpt ca b uff Ġfollow up Ġ19 67 Ġplasm al Ġbo ard Ġinn ov pan ze ur d Ġam iodarone Ġdesign s Ġinduc ers Ġpapill a Ġopportun istic Ġok t Ġth aw Ġrh o iod o d ys op i sp e Ġmat ch Ġla id Ġnyl on c ast en yl Ġr ii Ġit aly Ġt ate Ġan ab Ġat l umb er Ġserv ing Ġartif act Ġconflic ting idov udine am ically Ġas n Ġem uls c ope ed ta Ġpor ous cd c Ġt ically Ġher ds Ġtend er Ġcerebro v Ġaustral ian Ġpredisp osition event ful s ds Ġsu icidal Ġstri ated Ġdark ness Ġmim etic Ġison iazid on ym cn u induc ible erule us x x un its Ġsub normal iti dis Ġthyro toxic Ġenerg ies Ġpl ans Ġun eventful Ġser osal Ġscre w cepti ble Ġgh osts g sh r ontal Ġp estic Ġst 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