She had shrugged off their
requests, believing that the purported arthritis pain-relieving property of the drug
was just another “quack cure” that would produce additional side effects to make
her life even more unbearable than it already was. THE OFFICIAL POSITION OF THE ARTHRITIS FOUNDATION
Finally, Miss Jackson was swayed by the stand against DMSO taken by the
Arthritis Foundation. Prior statements indicated that its Committee on Unproven
Remedies was opposed to the legalization of the drug in the State of Florida, which
put the Arthritis Foundation in the position of opposition to use of DMSO for
relieving arthritis. Charles C. Bennett, vice president of public and professional education for the
Arthritis Foundation of Atlanta, Georgia, appeared before the House of
Representatives Select Committee on Aging. Mr. Bennett 
said, “The Arthritis
Foundation is not against DMSO. We would be delighted if it were established by
appropriate scientific procedures to be effective. I don’t think the safety question
seems to be a major one. That is pretty clear. But the question of effectiveness for
arthritis, particularly for inflammatory arthritis, particularly for chronic arthritis, is
not clearly resolved. The question [is one] of finding an agent that will deal with
the pain problem in a disease that goes on and/or involves a search for somethingthat works not just for a short-term overnight basis, but in a long-term chronic
use.”
The Arthritis Foundation thus changed its position, in a way. From
disapproving legislation in 1977 to permit use of DMSO by individual states and
accepting the 
ad hoc
 Committee on Dimethyl Sulfoxide of the National Academy
of Sciences–National Research Council’s negative report, the Arthritis Foundation
has now endorsed it for limited use as a pain reliever. “DMSO is by no means a worthless drug,” Bennett said. “It appears to work as
a local analgesic and therefore might be useful in a host of conditions causing
pain. But there is no scientific proof that it reduces swelling and inflammation
(which are of such critical importance in rheumatoid arthritis, for example), or that
it changes the underlying course of any connective tissue disease.”
In summary, the Arthritis Foundation told people who have rheumatoid or other
inflammatory arthritis that DMSO was not the drug for them. They needed more
than pain relief; they had to have the inflammation suppressed, something even
aspirin in proper dosage can do, but DMSO can’t, they said. The Foundation officials wanted the FDA to get DMSO approved for lesser
pain problems—without waiting for time-consuming trials needed to clear up
questions about the drug’s usefulness for serious systemic conditions, Bennett
said. He indicated that his organization was taking a neutral stand. He
equivocated. The Mike Wallace television presentation changed Miss Jackson’s thinking
about having the treatment, no matter what official position was held by the
Arthritis Foundation. About a week after the first broadcast she telephoned for an
appointment to see a physician who prescribed DMSO. She arranged
transportation and also borrowed the necessary funds to pay for the treatment. Average charges in the United States for the entire course of DMSO arthritis
therapy under medical supervision, including medication for three months, vary
from one physician to the next depending on what geographical area he practices
in, but it averages 
about $950 for the first week and $700 for the second week, if
it’s needed. The first thing the patient noticed upon entering the doctor’s office was the
smell. It was not the antiseptic aroma of alcohol common to most medical
facilities; it was the pungent odor of garlic. “Pardon our odor. It’s DMSO at
work,” read a sign in the reception room. Miss Jackson was introduced to the standard protocol for arthritis therapy, with
DMSO and diet as the initial part of her program.THE PROTOCOL FOR DMSO ARTHRITIS THERAPY
The DMSO Society of Florida, Inc., recommends that any patient treated with the
solvent be educated in the full anti-arthritis program of DMSO and diet as well as
receiving direct physician care. The program for Miss Jackson, therefore, was a
learning experience as well as therapy. The doctor acted as teacher. A complete nutritional workup was done, including the prescribing of
megadoses of nutrients, especially pantothenic acid, niacinamide, ascorbic acid,
and other vitamins and minerals in the form of supplements to the diet. A typical
patient with inflamed joints, such as Joanna Jackson, follows the specific protocol
for DMSO arthritis therapy. She consulted with the doctor for an evaluation of her existing health problems. A physical examination was carried out, including a number of clinical tests to
determine the extent of her limitation of motion in the hands, arms, feet, legs, hips,
back, shoulders, neck, and other articulations. Grip strength was measured. She had a basic series of laboratory blood tests and urinalysis performed. An
overly-detailed number of laboratory testings was not done, because as an
arthritic, the patient had already gone through too many examinations, probably
every one in the book. This overtesting for arthritics is an all-too-frequent practice
in most medical establishments. It is a waste of the medical consumer’s money. Miss Jackson did have a sedimentation rate, liver function test, hair analysis,
computerized diet evaluation, and some other checkups. It is important to know what the patient eats, since prior observations of
arthritic people have shown that sugar taken in excess brings on joint symptoms. (I
will have more to say on this topic a little further along in this chapter.) The
computerized diet evaluation gave the doctor clues as to what nutrition education
was needed. With completion of the pretesting, the entire treatment program was 
explained
to the patient. She was handed the informed consent statement (see 
Figure 7.1
) to
read and sign in accordance with the official position of the Florida Medical
Association, described in 
Chapter 2
. For Miss Jackson, intravenous injection of DMSO using a half dose (0.5 g/kg
of body weight) was begun the first treatment day. The infusion procedure takes
three or four hours depending on the speed of the fluid flow into the vein. The next
day and for those treatments administered thereafter, the full dose (1.0 g/kg mixed
into 1,000 cc of fluid) was given. There are five treatment days in a week, extending from Monday to Friday, andone series of a week’s injections usually are sufficient, except for people suffering
with arthritis of the spine. It takes spondylitis patients longer to respond, so that
two weeks of infusions may be required. Although no health insurance policy was reimbursing the patient for the DMSO
arthritis therapy, Miss Jackson financed a second week of treatment herself
because of the improvement she saw developing in her joints. At the start of her
second week of care, she was feeling more comfortable than any time in the recent
past. A tape-recorded treatment room dialogue between the doctor and the patient
went like this:
Doctor:
 Tell me about your progress, Joanna. Jackson:
 I think I’ve improved a lot. Doctor:
 In what areas, specifically? Jackson:
 Well, when your nurse tested my hand grip with that blood
pressure device a few minutes ago, my strength had improved from only
twenty pounds of pressure a week ago to sixty pounds today. Doctor:
 Three times as well; that’s one of the best test results we’ve
had this month. Good progress! Jackson:
 But all my fingers still won’t close in a fist. Doctor:
 Those fingers are quite deformed; they may never fully close. Jackson:
 But now these two close all the way [index finger and third
finger on the right hand] where they didn’t before. Doctor:
 Any other progress to report? Jackson:
 Yes, my feet are better. Doctor:
 How can you tell? Jackson:
 Because I can walk without canes. I can pick my feet up
higher and bend my knees without pain. And my ankles don’t hurt
anymore. I think there’s less arthritis in my leg joints, don’t you? Doctor:
 Yes, if you’re picking up your feet well off the floor, I would
say there’s less inflammation present. And you’ve definitely noticed a
difference when you walk? Jackson:
 I sure have! I can do deep knee bends, where I hadn’t been
able to since I was nine years old. Doctor:
 Be sure to put plastic wrap over your joints below the waist
after you’ve painted them with the solution and place gauze or another
wrapping over that. Leave these coverings on overnight. Sleep with them
on. The skin is quite resistant to skin reactions from DMSO down there.But don’t use Saran or other plastic wrap above the waist because it’s
liable to produce a blistering from the DMSO application under plastic. Jackson:
 I’ve been painting my knees with DMSO and covering with
Saran Wrap. You mean I should do the same to my ankles? For my hands
too? Doctor:
 Do it for your ankles but not for the hands. You mustn’t
occlude the air over DMSO on any joint above the waist, because it will
cause blistering. Scientists don’t know why the skin is more sensitive
above the waist than below. Do paint your finger joints with the liquid—
all you wish, just as you’ve been doing.Consent Form for Arthritis Treatment
 
 
I, __________________, have had explained to me the DMSO form of
arthritis treatment, which includes DMSO intravenously and topically
(applied to the skin), large doses of Vitamin C, enzymes, such as bromelain
from pineapple, and a rigid dietary program. I understand that certain side
effects, such as nausea, depression, or skin rash, may occur. I am aware of the other modes of treatment and I have been advised by
Dr.__________________ to obtain at least one second opinion from a
physician specializing in traditional arthritis therapy. I also understand that
DMSO is not approved by the Federal Food and Drug Administration for
the treatment of arthritis. Lastly, in most cases, DMSO IV therapy is not covered by Medicare or
other forms of insurance. WITNESSES:
__________________  
__________________  
(Signature)
(Signature)
__________________
__________________
(Date)
(Date)
 
Figure 7.1
 Informed consent statement. I will give a complete description of this plastic impervious wrapping
technique in the next section, but let us finish following Joanna Jackson through
her first week of treatment. She had been taught how to apply the topical DMSO on the first treatment dayand the arthritis diet with its initial supply of supplements was given to her, too. The second day Miss Jackson received a further explanation of the diet. Gentle
passive exercises were given to her and more active ones were demonstrated for
her own exercising at home. The third treatment included a demonstration of how to put on the impervious
wrapping. The nurses also gave lectures on the significance of hair and diet
analyses. Reports in writing about her hair and diet analyses were received by the
patient within ten days of the testings. All the while Miss Jackson was being
evaluated by the doctor during her physical examinations. The fourth treatment day consisted of more IV DMSO and the doctor’s formal
lecture on nutrition. Family and friends were invited to listen to the lecture so that
the patient would receive support at home when she attempted to change her eating
lifestyle. Miss Jackson had 
prescribed for her daily doses of flavored cod liver oil
for its vitamin A, D, and E contents. She applied it topically as well as taking it
orally. At home, the patient was instructed to swallow one teaspoonful of cod liver
oil with lemon juice twice a day to keep her blood level elevated. Cod liver oil
aids the action of DMSO. Also, more passive exercises were given to Miss
Jackson at that visit. On her final visit she went through the entire diagnostic testing again in order to
compare her readings with the baseline record of when she first arrived. Also, if
Miss Jackson had not elected to remain another week, she ordinarily would have
received a three-month supply of DMSO consisting of four bottles of the oral and
two bottles of the topical, with an explanation of when and how to use them. As it
was, at the end of the second week she took home a six-month supply. Every IV treatment procedure was the same. The patient was instructed to eat
a good breakfast each morning before the IV hookup except on the mornings when
blood was to be drawn for testing. Hookup was between 8:00 
A.M
 and 8:30 
A.M
, no
later. She brought a snack to eat during the hours of treatment. There was no
restriction of bathroom privileges, because anybody could go to the toilet carrying
the IV bottle still attached in the vein. One merely needed to hold the IV bottle
high in the opposite hand from the IV needle. The IV needle hand had to be kept
low and be prevented from getting bumped. There was a hook in the bathroom next
to the commode, from which the patient could hang the bottle. THE IMPERVIOUS WRAPPING TECHNIQUE
Keypunch operator Irene A. Brooks of Bradenton, Florida, had horrible left kneepain from osteoarthritis. Her comfort came merely from the application of topical
DMSO under an impervious wrap, the kind of plastic packaging material
commonly employed in the kitchen, for example, Saran Wrap, Glad Wrap, and
Handi Wrap. For three months Mrs. Brooks followed the wrapping procedure
applying it each time her knee flared with pain. Then she felt relief, at least
temporarily. The impervious wrapping technique consists of first putting on the topical
DMSO liquid, gel, cream, or ointment to cover the area of discomfort. Do not rub
in the medication but apply it lightly with the aid of a cotton ball, wooden cotton-
tipped applicator, soft and narrow paintbrush, or just your fingers. Wrap a thin layer of gauze bandage over and around the affected area. Next,
cover the entire bandage and solvent coating with plastic wrap. Leave the impervious wrapping in place for two hours the first time. If no skin
irritation develops, the next time you may leave the wrapping alone for the entire
period you’re sleeping. Or, you may keep it in place during the day. Do not wash the treated area with harsh soaps, other solvents, or household
chemicals that could contribute to skin irritations. The DMSO alone may bring on
a rash or irritation—in which case discontinue the impervious application. The plastic wrap technique may be used for parts of the body below the waist
such as the hips, knees, ankles, feet, or areas in between. Do not use this
procedure for the upper body—the arms, hands, trunk, neck, face, shoulders, or
back. Plastic seems to be too strong for covering areas above the waist and
excludes the air from the DMSO-treated skin. THE DMSO ANTI-ARTHRITIS DIET AND FOOD
SUPPLEMENTS
For any arthritic person daily diet becomes extremely important. The end products
of red meats such as beef, pork, veal, and lamb are particularly antagonistic to
inflamed joints. Consequently, red meat should be eliminated from an arthritic’s
diet at the beginning of treatment and during acute flare-ups. The Clinica Manner (Manner Clinic) Metabolic Research Foundation, P.O. Box 434290, San Ysidro, California 92143-4290, (800) 433-4962 or (800) 248-
8431, recommends the Manner Metabolic Therapy A for use with DMSO. Developed by the late Harold W. Mannner, Ph.D., former professor of biology and
chairman of the Biology Department of Loyola University of Chicago, MetabolicTherapy A consists of an anti-arthritis diet and various food supplements. For an
overview of the general diet, see 
Table 7.1
, which presents the foods allowed and
the foods to be avoided while following the DMSO protocol. In addition to recommending that certain foods be avoided, the Foundation also
advises that pesticides, food additives (especially monosodium glutamate, or
MSG, and other additives ending with 
-ate)
, and artificial colors, flavors, and
preservatives be avoided. Furthermore, sugar should be avoided, both by itself and
processed into foods. Prolonged intake of refined sugar (and other refined products) is a major
contributing factor in arthritis. Refined sugar depresses vitamin C stores. The
highest concentration of vitamin C in the body is in the adrenal glands, and chronic
vitamin C deficiency (hypoascorbemia) leads to adrenal exhaustion. With
prolonged adrenal deficiency, there is a deficiency of endogenous (body-produced)
cortisone. Rheumatoid arthritis is the end result of this prolonged attack of sugar
on the adrenal glands. Table 7.1
 The Manner Clinic Anti-Arthritis Diet
Food
Category
Foods Allowed
Foods to Be Avoided
Beverages
Herb teas (chamomile, mint, papaya; no
caffeine), fresh fruit juice, fresh
vegetable juice, purified water
Alcohol, cocoa, caffeinated
and decaffeinated coffee,
carbonated beverages,
canned and pasteurized
juices, artificial fruit drinks
Dairy
Products
Raw milk, yogurt, butter, buttermilk in
limited quantities, non-fat cottage
cheese, white (Farmer) cheese
All processed and imitation
butter, ice cream, toppings,
all pasteurized cheeses
Eggs
Poached or boiled (one per day)
Fried or scrambled
Fish
Fresh white-fleshed, broiled or baked
Non-white-fleshed, fried or
breaded
Fruit
All dried (unsulfured), stewed, fresh,
frozen (unsweetened)
Canned, sweetened
Grains
Whole grain cereals, bread or muffins
made from rye, oats, wheat, bran,
buckwheat, millet, and other whole
grains; cream of wheat, brown rice,
White flour products, hull-
less grains and seeds such as
pasta, crackers, macaroni,
snack foods, white rice,whole seeds of sesame, pumpkin,
sunflower, flaxseed
prepared or cold cereals,
cooked seeds
Meats
Poultry, but never fried or breaded
All red meat products such
as beef, pork, lamb, veal
Nuts
All fresh, raw nuts
Roasted and/or salted,
especially peanuts
Oils
Cold-processed such as safflower
Shortening, refined fats and
oils (unsaturated as well as
saturated), hydrogenated
margarine or hydrogenated
nut butters
Seasonings
Herbs, garlic, onion, chives, parsley,
marjoram
Pepper, salt, hot spices
Soups
All made from scratch, such as
vegetable, chicken, barley, millet,
brown rice
Canned and creamed
(thickened), commercial
bouillon, fat stock
Sprouts
All, especially wheat, pea, lentil,
alfalfa, and mung
None
Sweets
Raw honey, unsulfured molasses,
carob, unfavored gelatin, pure maple
syrup (in limited amounts)
Refined sugars (white,
brown, turbinado), chocolate,
candy, syrups
Vegetables
All raw and not overcooked, steamed,
fresh or frozen, potatoes baked or
broiled
All canned vegetables, fried
potatoes in any form, corn
chips
“Demon Sugar” is also a major contributing factor in osteoarthritis, also known
as degenerative arthritis. Sugar depresses the blood phosphorus. The blood
calcium and phosphorus are kept in a precise balance by the body when in good
health. Any stress on the body, such as illness or refined sugar intake, will upset
the delicate and extremely important calcium/phosphorus ratio. Depression of the blood phosphorus by refined sugar causes a 
relative
increase in blood calcium. The parathyroid gland, confused by the “low”
phosphorus level, thinks the blood needs more calcium and acts, through the
release of parathyroid hormone, to pull calcium out of the bones. So now there is
even more calcium in the blood. But the body knows that too much calcium in the
blood can cause sudden death so, to protect from hypercalcemia and death, thebody acts in two ways to eliminate this excess calcium. It eliminates the calcium
in the urine and, more germane to our discussion, 
it deposits it in soft tissues, such
as arteries, and in the joints. The prolonged use of refined sugar leads to a veritable army of aggressors
released against your body, resulting in arthritis, arteriosclerosis, diabetes, chronic
infections, and osteoporosis. It’s popular to believe that “you are what you eat,” but this is not entirely
correct. The food must be digested and absorbed into the blood stream before
nutrients can do the body any good. Arthritis is one of the degenerative diseases,
which indicates that digestion is incomplete for ingested materials. The food is
poorly absorbed, so that the body joints are insufficiently nourished. To overcome poor absorption and decrease the stress placed on the gastric
glands and the pancreas, a tablet containing hydrochloric acid, pepsin, and
enterically coated pancreatic enzymes should be taken at each meal. The Manner
Clinic has made such nutritional supplementation a part of its anti-arthritis regime,
and I believe in it also. It ensures the proper digestion of food. Note:
 In some
people excessive gas might follow gastric juice supplementation, which means that
you already have enough hydrochloric acid. In this case, take only tablets
containing the pancreatic enzymes. The Manner Metabolic Therapy A for arthritis also includes the following
supplements:
2,000 mg vitamin C with each meal
400 IU vitamin E with each meal
1,000 mg pantothenic acid with each meal
2 multivitamin capsules after each meal
25,000 IU vitamin A (or 2 teaspoons cod liver oil) twice daily
2,500 IU vitamin D three times daily (including at bedtime)
The amounts to be taken of all of the above supplements can be cut in half
after symptomatic improvement is noticed. Vitamin A should be taken in emulsified form to avoid liver involvement. Up
to 500,000 IU (International Units) of liquid vitamin A have been given without
side effects by physicians practicing metabolic therapy at such places as the
Health and Wellness Center of Minneapolis or the Degenerative Disease Medical
Center of Las Vegas. If emulsified vitamin A is not available, I recommend instead
that you consider using for a few days 50,000 to 100,000 IU of regular vitamin A.Note:
 Observe your skin. If drying or scaling occurs, discontinue vitamin A for
one week. If any other signs of vitamin A toxicity, such as headaches, hair
changes, or dryness of the mouth, occur, discontinue the vitamin A for a week and
resume with a reduced dosage the following week. Continue with a half-dose daily
with a two-week-on one-week-off routine. Symptoms of vitamin A toxicity
disappear as soon as you reduce your daily dosage. Vitamin C is quite necessary for an arthritic, and megadoses ranging up to 15 g
should be taken daily, according to the Manner Clinic. I suggest a somewhat lesser
amount, at least to start. Make sure the vitamin C is in the form of ascorbates,
which have a neutral pH (acid-base balance) and, therefore, prevent problems with
acidity. Also, ascorbates contain the bioflavonoids that are necessary for the
proper metabolism of this vitamin. Note:
 Megadoses of ascorbic acid may cause
gastric disturbances such as diarrhea. Acute diarrhea will indicate the body’s
tolerance level has been reached, and you should reduce your dose until diarrhea
no longer is a problem. A therapeutic vitamin-mineral supplement should be taken morning and
evening as well. The tablets or capsules can be swallowed with a Protein Milk
Shake, which the Foundation also recommends (see 
here
). In addition to the supplements already mentioned, also recommended on a
daily basis are 3 g of calcium, one-quarter pound fresh liver or 15 liver tablets,
fresh wheat germ, and 6 tablespoons bran (on morning cereal). A superoxide
dismutase (SOD) supplement is also encouraged. Recent laboratory work has
indicated that people suffering from arthritic or rheumatic diseases have a
decreased amount of SOD in their circulating blood. SOD is a metalloprotein, a
natural enzyme. To overcome an SOD deficiency, a tablet or two containing the
enzyme could be taken with each meal. Such a supplement will have an anti-
arthritic effect. The anti-arthritic diet and supplement regime may be begun with a two-day
juice fast, which is recommended by the Manner Clinic. To allow for taste
acclimation to juices, a blend of 50 percent apple and 50 percent carrot juice
should be taken first. As rapidly as possible, eliminate the apple juice and add
other vegetable juices to the carrot juice. This is a way to ease into drinking
celery, beet, potato, and other vegetables as juices. Definitely don’t drink canned
juices, since the heat of canning destroys the vegetable enzymes. Prepare and drink
the juice each day to prevent oxidation of the liquid, and eat nothing solid for two
days.Protein Milk Shake
 
2 eggs
1
⁄
4
 cup yogurt
4 teaspoons calcium gluconate
1 tablespoon lecithin
1 tablespoon safflower oil
1 teaspoon granular kelp
1
⁄
2
 teaspoon magnesium oxide
4 cups skim milk
1
⁄
2
 cup powdered non-instant milk
1
⁄
4
 cup yeast fortified with calcium
1
⁄
4
 cup soy flour or powder
1
⁄
4
 cup wheat germ
1 teaspoon vanilla (not vanillin)
In blender, thoroughly mix eggs, yogurt, calcium gluconate, lecithin,
safflower oil, kelp, and magnesium oxide. Add 2 cups skim milk, powdered
milk, yeast, soy flour, wheat germ, and vanilla, and mix. Add remaining 2
cups skim milk, plus fruit or fruit juice, carob, honey, additional vanilla, or
other flavoring to taste, if desired. Drink two-thirds of a cup six times a
day (with each meal and at midmorning, midafternoon, and bedtime). Follow the anti-arthritis diet and take the food supplements while you are
under treatment with DMSO. Continue on this diet as part of your lifestyle
thereafter. And absolutely avoid refined sugar in any form. DETOXIFICATION
A process of detoxification goes along with the anti-arthritis diet and
supplementation program. Each day a coffee enema could be administered. (It’s
the only useful purpose for coffee.) Cool one cup of brewed (non-instant) coffee tobody temperature and introduce it into the rectum with a rectal syringe. Retain the
coffee for fifteen to thirty minutes. The caffeine-stimulated secretion of bile is an
important part of the detoxification plan, as it helps to restore the alkaline
condition of the small intestine. Continue colonic irrigation with coffee enemas until the bowel movements
become regular, twice a day if possible. Part of the arthritic’s problem is that he or
she does not get rid of toxic products catabolyzed by the body. The bowel habits
are irregular. Drinking four to eight glasses of freshly prepared vegetable juices
also helps to bring bowel movements back to normal. THE MANNER COCKTAIL FOR ARTHRITIS
The Manner Clinic utilizes what it calls the Manner Cocktail for the permanent
relief of various forms of arthritis including tendinitis, gouty arthritis, bursitis,
rheumatoid arthritis, and osteoarthritis; chronic back disorders; and acute sprains
and strains. The cocktail consists of a combination of vitamin C, amygdalin, and
DMSO. It was developed by Dr. Manner around 1987 to act as a chelating agent,
which grabs metallic ions out of the body, and to enhance electron density at the
oxygen atom and the steric availability of the oxygen, which increases the packing
of the oxygen atoms so that more oxygen is present to nourish the cells. Being both anti-inflammatory and analgesic (causing the reduction of pain) in
its action, the DMSO infusion is exceedingly useful for the correction of arthritis
and its many complications. To learn more about the administration of DMSO via
the Manner Cocktail, contact the Manner Clinic. REPORTED ARTHRITIS-DMSO INVESTIGATIONS
In 1989, five Italian physicians investigated the complications and symptoms of
rheumatoid arthritis and tested the efficacy of dimethyl sulfoxide on the overall
condition. Writing in the journal 
Minerva Medica
, the doctors concluded: “In this
study we have investigated the role of oral dimethylsulfoxide (DMSO) therapy in
two patients with primary amyloidosis (AL) [a form of rheumatoid arthritis] with
secondary amyloidosis (AA) to long-standing rheumatoid arthritis. DMSO
treatment produced no beneficial effects in the patients with idiopathic [cause
unknown] amyloidosis. Instead the patients with secondary amyloidosis
experienced a subjective improvement, a decrease of inflammatory activity of therheumatoid arthritis, and an unequivocal improvement of renal [kidney] function
following three to six months of DMSO therapy. No serious side effects of DMSO
were observed except for unpleasant breath odour. We conclude that a treatment
with oral DMSO may prolong life of patients with secondary amyloidosis.”
1
With acute gouty arthritis in a 1981 Russian study, DMSO was administered
for the condition and compared to indomethacin, a drug therapy. The DMSO
treatment was more effective for gout. 2
Favorable effects for juvenile rheumatoid arthritis were reported in a case, in
1984, when DMSO was administered to a girl with secondary amyloidosis as a
complication of her arthritis. Dimethyl sulfoxide was applied by topical
application to the skin. The young girl’s gastrointestinal symptoms and massive
proteinuria (protein in the urine) improved. Her decreased left ventricular function
of the heart and her kidney’s creatinine clearance also improved remarkably. The
ten collaborating Japanese physicians on this case came to the conclusion, “The
favorable effect of dimethyl sulfoxide in this single patient deserves further study
in a controlled trial.”
3
Two Russian orthopedists used DMSO to treat rheumatoid arthritis without
complications, as published in their 1981 case report. 4
Another group of Russian doctors in 1983 investigated DMSO for the
treatment of rheumatoid arthritis and compared its effect to colchicine. DMSO was
more advantageous and produced no kidney complications. 5
Ordinarily Still’s disease is a chronic arthritis developing in children before the
age of sixteen. There are several different forms of arthritis affecting children, and
some authorities confine the diagnosis of Still’s 
disease to the following: a disease
of childhood marked by arthritis (often involving several joints) with a swinging
fever and a transitory red rash. There is often severe illness affecting the entire
body and the condition may be complicated by enlargement of the spleen and
lymph nodes and inflammation of the pericardium (heart muscle) and iris of the
eye. But seven Japanese clinical investigators reported on DMSO usage for a case
of Still’s disease in a thirty-seven-year-old man with the adult-onset variety. He
suffered from severe diarrhea. The Japanese doctors’ viewing of the patient’s upper and lower gastrointestinal
tract by means of endoscopy revealed swollen mucosa with white patches,
erosions, bleeding, and amyloid deposits. As previously defined, amyloid is a
glycoprotein, resembling starch, that is deposited in the internal organs in the
presence of the pathological condition amyloidosis. Amyloidosis is infiltration ofthe liver, kidneys, spleen, and other tissues with amyloid. The clinicians took
biopsy specimens from the man’s bowel. After they administered three months of therapy with DMSO and prednisolone,
improvement in the endoscopic appearance of the patient’s gastrointestinal tract
was observed. Amyloid deposits in the biopsy specimens were reduced in the
stomach and appeared totally negative in the large intestine. Their patient had a
successful recovery from the use of DMSO. 6
The author of 
Malpractice
 and 
Confessions of a Medical Heretic
, Robert S.
Mendelsohn, M.D., of Chicago, who before he died was Associate Professor of
Preventive Medicine and Community Health in the School of Medicine of the
University of Illinois, said in an interview: “From my experience with DMSO
seventeen years ago, I believe it has to be approached the same way as any other
medicine—with extreme caution. Should it be used for arthritis? I would regard it
as any other drug—to be employed when everything else fails. My impression is
that once a person begins living right in terms of good nutrition, sufficient exercise,
and healthy lifestyle, his arthritis will improve all by itself. You don’t have to
resort to DMSO just as you don’t need Indocin, codeine, Motrin, Butazolidin, gold
injections, and other anti-inflammatory arthritis drugs. “This, despite our seeing very few reports of DMSO side effect—and no
fatalities. If I had to rank therapies, I would place DMSO way ahead of the
conventional anti-arthritic medicines. It is preferable to any of them. But I would
rank DMSO use behind proper diet and good nutrition. . . . I suggest water
exercises for crippled arthritics. What 
happens if you can’t do those water
exercises? Well, if you’re stuck then you go to DMSO. “My argument is that if the Government is going to prevent you from using
DMSO, it should absolutely keep you from using all the other conventional
arthritis drugs, which we know have many dangers. We don’t know of any dangers
with DMSO. Of course,” added Dr. Mendelsohn, “this kind of reasoning would put
the rheumatologists out of business. “For all the people who have come to me for relief of arthritis, what have I
done? I’ve taken them off the drugs they’ve been on; I improve their diet; I start
them on the water exercises. It disturbs me that I’ve not prescribed DMSO; I
wonder why this is? “It’s a question many physicians will be putting to themselves in the
forthcoming weeks. Thousands of arthritics have been wondering the same thing. When will we be able to get DMSO by prescription or over the counter, as we can
with other anti-arthritic medications?”CHAPTER 8
Adapting DMSO for Foot and Leg
Problems
In the spring of 1963 DMSO was still in laboratory research, and not yet adapted
for human application. That is the period when Sam Bell of Bloomington, Indiana,
now the track coach at Indiana University but then coaching at Oregon State
University in Corvallis, Oregon, came in contact with the solvent as a possible
treatment for leg and foot problems. “At that time, I had two athletes who were having leg problems,” Mr. Bell told
Senator Edward M. Kennedy, who chaired a hearing conducted July 31, 1980, by
the Senate Subcommittee on Health and Scientific Research of the Committee on
Labor and Human Resources. The hearing was an in-depth look by Senators
Howard M. Metzenbaum (D-Ohio), Richard S. Schweiker (R-Penn. ), and Orrin G.
Hatch (R-Utah) who joined Senator Kennedy on the “Examination of Testing of
DMSO and FDA’s Role in the Process.”
The two athletes Sam Bell described were Morgan Growth and Norman
Hoffman, both world-class 800 meter track athletes and both potential scorers in
the National Collegiate Athletic Association (NCAA). But Growth had
inflammation of the Achilles tendon and Hoffman suffered with a pulled hamstring
muscle. “We had a chronic problem with both of them,” Sam Bell continued, “and what
we were doing trainingwise was having no effect on them. I had read in the paper
some of the things that Dr. Jacob had discovered with DMSO, and I called him at
the University of Oregon Medical Center and asked him if I could bring these two
athletes up to see him. We went up there to visit with him, and he examined them
and gave us some DMSO to use and told us how to use it. We used it topically;
that is, we put it on the skin.”
The recovery for Morgan Growth’s leg tendon was nothing short of
remarkable. The Achilles tendon injury, according to Coach Bell, is a chronic
injury that hardly ever rights itself when one is really hurt. But that spring, Growth
was the NCAA champion in the mile run at the University of New Mexico. Andthe hamstring problem for Norm Hoffman that kept him away from training was
solved completely. Hoffman ended up becoming the 1963 NCAA champion in the
880 meter run. Coach Bell had a little of the DMSO left over, and that fall, while he was doing
some yard work, he sprained an ankle grubbing out a tree stump. It was the
renewal of a prior injury from his college football days. “I ended up deciding
maybe I ought to experiment with DMSO myself,” said Bell, “and I gave myself
six treatments over a period of three days. My ankle, because of it being an old
injury, always swelled up very badly whenever I sprained it again. Within three
days, I had no swelling, no soreness, no discoloration; I could do anything I had
been doing on it.”
His next experience with the drug came in the fall of 1964. At that time, Bell
was running a two-day Olympic trial in track and field at Oregon State University. One of his participants was a young man, Daryll Horn, whom Bell anticipated
would win a place on the United States Olympic team. Horn was the number two
ranking long jumper and the number two ranking triple jumper in the country. Triple jumping entails a hop, step, and jump in a three-stage take-off, a very
difficult feat that takes exceedingly strong legs. Daryll Horn had graduated from
Oregon State University in midyear, 1963, and had gone into the air force. He was
then allowed on detached duty to train for the Olympic trials. Just prior to those
trials he was training at Stanford University in California where the Olympic trials
were to take place. Bell flew to southern California to observe the Olympic trials, but he couldn’t
find Horn in the training camp there. He asked Peyton Jordan, the coach from
Stanford University, where the young athlete was supposed to be. Jordan said,
“Well, I hate to tell you this, but he had a massive hamstring pull on Monday, and
he is staying at Palo Alto to try to get treatment as long as possible before he
comes down here. But there is no way he will be able to compete.”
Immediately Bell got on the phone to Daryll Horn in Palo Alto, California, and
heard the athlete say, “Coach, I am black and blue from the gluteus [the big butt
muscle] to down below my knee. I cannot walk without a limp.”
The coach told Horn to “get on an airplane and get down here as fast as you
can.” Then he phoned Dr. Jacob in Portland, Oregon, and asked him if he could get
some DMSO to treat the young man. “If you can have someone pick it up, I’ll supply the DMSO,” responded Dr.
Jacob. Bell asked a friend to go to Dr. Jacob’s office and carry a supply of thesolvent to the Portland airport where he found a stewardess who would take it to
the Los Angeles airport. The coach met this airplane and got the DMSO. Daryll Horn arrived for treatment on the next flight in from Palo Alto, on a
Thursday with the Olympic trials scheduled for Saturday afternoon. Bell doused
the athlete’s injury with DMSO. The odor caused Horn’s roommate to change
sleeping accommodations. Skin irritation developed on Horn’s leg, which they
ignored. The immense discoloration of the leg injury started to fade right away and
the pain went with it. “To make a long story short,” said Bell, “we practically bathed Daryll in the
stuff for two days, and on Saturday afternoon, he missed [making] the Olympic
team by a quarter of an inch. On Sunday, we went back and competed again, and
we continued to treat him over Saturday night and Sunday morning, and he went
back and competed again and he missed the Olympic team in the triple jump by a
half-inch. He obviously did not come back to where he was, but the fact that he
was even able to compete, I thought was a minor miracle. He competed with no
discoloration of the leg; it was totally gone in two days, and the soreness was
gone. I think, obviously, the strength was not quite back there, but the fact that he
was able to operate at all is an amazing thing.”
PUTTING DMSO TO USE IN FOOT CARE MEDICINE
At about the same time Sam Bell was making his attempt to get Daryll Horn
accepted as a member of the United States Olympic team, DMSO was intriguing
scientists throughout the world. Pharmaceutical companies were beginning to
allocate quantities of the drug for research. They solicited participation from
proven and respected medical investigators who were willing to enter into clinical
trials in their separate specialties. They started to use DMSO for burns, arthritis,
skin conditions, musculoskeletal pain of all kinds, and many other conditions. “Soon there were hundreds of publications reporting on ‘miraculous cures’ with the
drug, for everything from ingrown toenails to vascular headaches,” said Dr. Jack
C. de la Torre, Associate Professor of Neurosurgery and Psychiatry at the
University of Miami School of Medicine. Merck and Company, one of the several pharmaceutical companies considering
DMSO as a commercial product, approached various medical 
organizations to
select outstanding members as investigators. The American Podiatry Association
(APA) was asked early in 1965 to select doctors of pediatric medicine to
participate. I, Morton Walker, D.P.M., had just won the 1964 APA SilverAnniversary Gold Medal for scientific research and writing, the highest award ever
presented by the American Podiatry Association. Therefore, Merck and Company
executives were directed to me as a candidate for their DMSO research project. The Food and Drug Administration had already approved other clinical
investigations that had previously brought me nine additional research, writing, and
scientific exhibit awards. I eventually won twenty-two such awards. Merck and Company offered to pay all costs for the study and record keeping
of DMSO treatment on foot and leg problems. During that 1964–1965 period, the
drug companies of Merck, Syntex, Squibb, Geigy, Schering, and American Home
Products collectively spent $20 million to finance clinical trials. There were 1,500
clinical investigators involved, most of them physicians. In the spring of 1965
when the Merck pharmaceutical company made its grant offer to me, Connecticut
podiatrists were not permitted by law to give internal medication, so the drug
would only be used on the skin for foot and leg troubles. The year before this new Merck and Company clinical trial, I had concluded a
study for the Armour Pharmaceutical Company on the chymotrypsin (a pancreatic
enzyme) product Chymar (whose name has now been changed to Biozyme). For
that investigation, I applied the Chymar ointment under an impervious wrapping. It
was the first time plastic coverings were used in podiatry for driving a medication
into the locally affected inflamed tissues of the feet, for example for corns and
calluses. I adapted this technique for the DMSO clinical trial, too, and it worked
quite well. Alternately, I inaugurated a technique of driving in the DMSO, especially for a
deep-seated lesion like a painful heel spur, using ultrasound. Instead of the usual
ultrasound gel or mineral oil, DMSO was applied as the coupling agent between
the ultrasound machine’s quartz crystal and the skin. This worked well. I was able
to eliminate much of my patient’s heel spur inflammation. These foot and leg studies were conducted over a four-month period starting in
1965. Certain precautions were taken before beginning the studies. Much reading
on the subject was done. For two months, only a few podiatric patients received
the DMSO treatment. A long memorandum from the pharmaceutical company
arrived September 8, 1965, detailing all the benefits of the product, how the doctor
should use it, 
what it’s for, how DMSO acts in the body. This was a memorandum
sent to every medical researcher in the country who had been certified by the FDA
to use DMSO on an experimental basis. A representative of Merck and Company
arrived with more DMSO supplies and with report forms for recording patient
responses in a full-scale clinical trial.Unknown to me, a woman in Ireland died from the administration of DMSO on
September 9, 1965. This report was not 
documented
 and, in all probability, she
died from other causes simply while using DMSO. But the death produced panic
among officials of the FDA and brought great political repercussions for Dr.
Stanley Jacob and his co-workers at the University of Oregon. No notification
from the pharmaceutical company or the FDA relating to this occurrence arrived,
however, and the clinical investigation on DMSO for foot and leg problems
continued. I performed clinical trials on the lower extremity problems of 124 patients. Excellent results came out of the different DMSO applications. Records were
kept; objective and subjective observations were reported on the furnished forms;
more DMSO supplies were requested. This podiatric study of DMSO came to an abrupt halt November 10, 1965,
when a “Dear Doctor” letter arrived advising that all research on the project must
cease. The FDA demanded that the used and unused supplies of DMSO and all
records of patients for whom it was administered must immediately be returned to
the sponsoring pharmaceutical company. I didn’t have to mail these items because
a company representative promptly arrived to take everything away—all patient
reports, supplies of DMSO, even duplicates of the records. Instructions were given
to report any deleterious effects from the product’s use, but there were none. No
published report ever appeared in the medical literature on this four-month
podiatric study of DMSO’s adaptation for a variety of foot problems. All the
records of clinical trial were confiscated, and what follows are strictly the
impressions of this researcher twenty-seven years later. They are based on the
patients’ personal foot health histories with relation to their individual toe, foot,
ankle, or leg problems. BIG TOE BUNIONS
Bunions are formed from deviation of two adjoining bones, usually at the joint of
the big toe and the first metatarsal. There are two types of bunion. The acute type, or bursitis, is sudden and
painful. If it is not given proper attention, the acute bunion may 
gradually develop
into the second type—the chronic bunion, or 
hallux valgus
, which is an often
painless deformity of the big toe. Sometimes, however, it aches a lot. The bursitis bunion is an inflammation of a bursa, a sac containing fluid about
the consistency of the white of an egg. This bursa acts as a lubricant between theskin and the bones. Continual irritation by external pressure such as an ill-fitting
shoe causes the sac to become inflamed, and the condition gets acute and painful
—a bursitis. Hallux valgus is a common affliction that strains the foot and produces an
abnormal prominence of the big toe joint. It widens the foot to bring about a loss of
balance. Standing and walking become difficult. Arthritis in the foot can occur
early in life from this condition. Osteoarthritis is a frequent consequence of ignoring the big toe bunion. Calcification at the points of stress comes on; joint expansion locks in; the
deformity can be accommodated only with bigger shoes. With DMSO application, the acute stage of bunion, primarily bursitis,
improved remarkably. Hallux valgus did not. The impervious wrapping and
ultrasound both worked well with DMSO painted onto the inflamed area. The
procedure entailed using DMSO and ultrasound as the office treatment and
sending the patient home with DMSO under the plastic cover to be held in place
with a protective felt padding and supportive strapping for three days. At the time of this study, no DMSO supply was ever dispensed for application
by the patient at home because it was uncertain what the side effects would be. It
was kept strictly under my control, and I made the applications in the podiatry
office. Invariably the pain of bunion disappeared by the time the patient returned. No
further treatment was needed until the patient brought on a resurgence of the
bunion flareup by wearing fashionable but abusive footwear. HAMMERTOES
The hammertoe, one of the most painful of foot ailments, is marked by contracture
of the tendons on the top of the foot. Accompanying this phenomenon is a laxity of
the ligaments and angulation of the second and third phalanges, the individual
bones of each toe. Tight shoes compress the feet and constrict the muscles that move the toes so
that the muscles waste away. The toe motions become puny and weak. The toe
seeks room anywhere it can in an ill-fitting shoe. It curls 
up and arches until the
toenail is nearly vertical. The affected toe may rise, contract, and overlap other
toes. Its tip may strike the ground with each step and become flat and squat. A
hard corn can form and the nail can split and grow inward. Although any toe may
be so affected, the second suffers most often. It is usually longer than the othertoes. The experimental DMSO treatment was the same as with acute bunions—first
ultrasound and the drug applied and then a dressing with impervious plastic
wrapped over the solvent. A return visit by the patient in three days saw the pain
gone from the deformed toe, although the deformity remained. The pain might
return a day or two later if nothing was done to permanently correct the
malformation. ARTHRITIS OF THE FEET
Arthritis can affect the joints anywhere in the body, including the feet. Arthritis in
the feet results in most instances from mechanical strain, not from infection. It is
sometimes associated with knock-knees, bowlegs, flat feet, and weak feet. The
condition also contributes to such deformities of the feet as fallen arches, high-
arched foot, hammertoes, bunions, and heel spurs. Although arthritis cannot be cured at this time, the aching distress and
discomfort that accompany the disease can be partially relieved. Treatment of
arthritis of the feet must be directed both at the general cause and to the relief of
local symptoms. The general treatment of the problem is the responsibility of your family
physician, for the entire body and its general breakdown may be involved. Treatment may involve building up your resistance with diet, exercise, relaxation
techniques, weight control, and other things that might constitute your lifestyle. Local treatment may include foot rest, heat applications, splinting, traction,
physical therapy, and the use of drugs. The specific causes will be looked at, such
as mechanical strains, allergic factors, climatic conditions, congenital defects,
tumors, infection, injury, toxins, disturbances of the circulation, poor nutrition, and
others. Using DMSO as a local treatment, it’s likely you’ll be able to help yourself a
great deal. The following regimen of care may give relief to a red, hot, swollen
arthritic joint, whether in the heel, the ankle, or the big toe. Arthritic toes respond
quite well to this procedure:
1
. Paint the acutely inflamed joint with a quantity of DMSO in about 70-percent
strength or a little higher concentration. Don’t go beyond 90 percent because
the method of wrapping that follows may bring about a severe skin reaction
from the DMSO under the hot wrap.2
. Apply several layers of roller gauze over the entire foot that’s inflamed. 3
. Rather than painting the skin directly, you might wrap with the gauze first and
then saturate it with DMSO. 4
. Cover the whole area with rubber sheeting or thin foam rubber. 5
. Apply a layer of flannel or felt that has been dipped in hot water and wrung
out. 6
. Put hot water bottles around the inflamed area or cover it with an electric
heating pad wrapped in towels. 7
. Hold in the heat by covering all the above with Turkish towels. 8
. Elevate the foot and leg in bed to a level with the heart. 9
. Continue this treatment for as long as you are comfortable with it, but not
longer than sixty minutes for any single application. 10
. Reapply the DMSO every four or five hours, as needed. 11
. After you’ve used this treatment for twelve hours (a maximum of three times),
remove pads, bottles, gauze, and wash the foot so as to take off any DMSO. Apply a soothing lotion or ointment of the cortisone family, or aloe vera to the
treated foot. Caution:
 Note that you are using two forms of therapy in this procedure—
DMSO with its anti-inflammatory properties, and moist heat with its own
inflammation-reducing effect. The heat seems to catalyze the DMSO into even
greater effectiveness. But I caution that you can get too much of a DMSO skin
reaction—even too much of an anti-inflammation response. Too much of anything
is no good. Therefore, I strongly suggest that you take precautions with this
treatment, at least the first few times you use it. Keep checking the condition of
your arthritic joint and the skin over it. Don’t allow skin irritation to set in. Take
your body temperature; if you become at all feverish, discontinue the procedure. Remove the wrappings as described in step eleven and soothe the foot. This is a
highly powerful way to rid the involved foot of an arthritic inflammation. In practice, in 1965, this method was used with success, but it was
administered by a doctor of podiatric medicine who knew the sort of reactions to
avoid. The pain, swelling, and other signs of inflammation disappeared from a
patient’s feet in the foot care office while the patient occupied a small treatment
room. He or she went home without discomfort, and the relief lasted several days. HARD AND SOFT CORNSAbout 40 percent of all persons who visit a podiatrist do so initially because of
hard and soft corn problems, and women comprise 80 percent of these people. Hard corns are growths of horny skin, generally on the top of the toes. Soft
corns grow between the toes. Both types can be easily distinguished from the
normal tissue surrounding them. Within a hard or soft corn is a central radix, or
eye, of hard gray skin, and around the center is a painful inflamed ring of skin and
flesh. The ring is raised and yellow. Pain usually is the main symptom. The corns come from friction and pressure arising from an underlying
prominence of bone. The sharp edge on the toe bone rubs the skin from inside and
sometimes wrong-fitting shoes rub the skin from the outside. The skin eventually
dies and builds up layer after layer to create the corn. Irritation and pain increase
as the corn grows. People suffering from corns can be relieved of their problem either temporarily
or permanently. Nobody has to feel the agony of hard corns. Temporary relief
does nothing to prevent the corns from growing again at the same place. It is
palliative. Painting DMSO on corns was just such a temporary measure. It was done after
the corn was shaved to remove the horny skin causing discomfort. No padding
with moleskin was necessary after palliative corn removal if DMSO application
followed the procedure; however, the corn soon returned without permanent
removal of the underlying bony prominence. CALLUSES
Calluses are thickened masses of skin that form on the weight-bearing surfaces of
the feet. They come from constant friction and pressure. The pathological callus
such as one developed on the ball of the foot is not healthy. This kind of plantar callus is surrounded by an inflamed red rim and has fluid
permeating the underlying tissue. It is often swollen, hot, and painful and
frequently appears as a hard, dry, hornlike mass of yellowish or grayish skin. It
may be thick in the center and gradually taper at the sides. Within its center could
be a deep, hard, gray central area that seems like a pebble when removed. Because the thickened skin of calluses loses its elasticity, the skin no 
longer
stretches to normal length across the ball of the foot when the feet are flexed. These calluses seem to “burn.”
Sometimes corrective treatment means redistributing the weight on the foot
with supportive orthotic devices worn in the shoes. Exercises may be prescribed.Footgear might be changed. Or surgical correction of the involved metatarsal bone
and the associated contraction of the toes may be required. Most of the time the
person with calluses goes to have them pared away. If DMSO is put on after such
paring, no moleskin padding is required to rid the area of tenderness. However,
DMSO does not penetrate the hornlike skin without such removal first. PLANTAR WARTS
Plantar warts grow on the sole of the foot as raised lumps of flesh. They are
benign tumor-like growths that are well supplied with blood vessels and nerves. You may mistake them for corns or calluses because they are covered with callus
tissue and because they hurt. The plantar wart is pearly white, soft and spongy, and has tiny spots, black,
brown, or red, in its center. These spots are the blood vessels. Walking flattens the
wart so that it remains thickened and rough in texture. Varying in size from a
pinhead to a silver quarter, it may grow either singularly or in clusters. It hurts
severely when pinched. Injury to the plantar of the foot allows entrance of a virus into the skin that may
cause the plantar wart to grow. In fact, there are wart seasons, those times in the
summer when people walk barefoot and bruise the bottoms of their feet. A variety of techniques to get rid of plantar warts exists. DMSO application is
not one of them. All it does is take away plantar wart pain after the overlying hard
skin layer is shaved. If this is done and a plastic wrap put on over DMSO, the wart
macerates, softens, and possibly may go away on its own. INGROWN TOENAILS
With ingrown toenails, the lateral edges of a nail penetrate the skin and cut into the
flesh of the toe. Unless soon corrected, severe complications can result. The complications of inflammation, infection, ulceration, and gangrene may
follow one another progressively. Anyone who suffers from ingrown toenails
seldom is able to endure the pain and usually seeks 
aid before the more serious
complications develop. Teenagers seem to be especially susceptible, perhaps
because they tend to disregard the early warnings that adults will heed. Injudicious cutting of toenails is the most frequent cause. At first, inflammation
appears, then in turn discoloration, a mild swelling, and some escape of fluid. Pusforms, redness increases, and the toe balloons with pain if these preliminary signs
are ignored. A bloody mass of material called “proud flesh” will arise at the edge
of the nail between the nail plate and the nail groove. If treatment has not been given by now, a dangerous infection may spread
along the whole toe, and red streaks will eventually appear along the top of the
foot. This needn’t occur when treatment is swift, painless, and permanent. DMSO relieves the beginning symptoms of ingrown toenails merely by placing
a drop on the inflamed area. But this may not be the best procedure because of the
other progressive symptoms leading to infection. CLUB NAILS
Older people sometimes have thick, ugly, deformed toenails, a condition that may
be symptomatic of a systemic disease or chronic injury such as jogging in poorly
fitting running shoes. Injury often causes the toenails to look discolored, elongated,
and thickened. Overgrown toenails are known as club nails. They may become extremely hard
and curl under the toes, to give the shape of a grotesque ram’s horn. Reduction of
these nails does not have to be painful. In fact, it’s best to keep a ram’s horn-like
toenail cut as short as possible so as to avoid providing surrounding parasitic fungi
a nesting place in which to grow. The nails are first rubbed with castor oil or warm olive oil combined with 90
percent DMSO. This softens and reduces sensitivity of the nails at their roots. Then they are cut with strong nail clippers. Smoothing down the rough edges is
required so that hosiery won’t be snagged. Besides, this gives the overly thick nail
a more pleasing appearance. However, the main purpose in the reduction of overgrown nails is to remove
pressure on the nail grooves and thus eliminate the source of discomfort. Reduction also leaves more space in the shoe in which the toe may move. More
room in the shoe may also relieve pressure and prevent corns from forming on
adjacent toes. After the above procedure is completed, the flattened nails may be 
painted
with a mixture of DMSO and oil again. This gives a prolonged effect of comfort
and brings the formerly compressed tissues underneath back to a more normal
state. Thereafter, to prevent overgrowing such as the club nail condition described
here, observe the following simple procedures:When you cut your toenails, cut them short, but cut them square—straight
across. Use toenail clippers. Do not, in any case, round the nails. After cutting, place one drop of DMSO in a medium strength onto the cut end. There is little in the human anatomy that does not serve a specific purpose. Just as the hair on the head has its function, so the toenails have theirs—in this
case, to protect the bones and the nerves of the toes. Yet because we wear shoes,
the toenails, instead of protecting the toes, can be a potential source of annoyance. However, we can insure ourselves against the problems they may cause by caring
for them properly. FUNGUS TOENAILS
Infections of the toenails caused by a fungus are among the most frequently seen
nail afflictions. One out of every four persons over the age of thirty who visit
podiatrists has such a nail malady. Fungus toenails are caused by parasites such as yeasts, molds, or fungi, all of
which grow as ringworm. These parasites are prevalent in shoes, which, because
they are the only item of clothing that is never thoroughly cleaned inside, are a
constant source of infection and reinfection. Fungus toenails appear dry, lusterless, scaly, and streaked; they are raised
from the nail bed; and they have a grayish-yellowish-brownish worm-eaten look. Part or all of the nail may be affected because, as the infection progresses, it
works back toward the nail root. The average person pays no attention to the nail’s
crumpled appearance because it is painless. But the infected nails are a source of
athlete’s foot. In treating fungus toenails, a podiatrist removes the crusted, powdery
substance that forms, and files the nail thin. He may prescribe the oral antibiotic
griseofulvin, ionize the area with copper sulfate, or apply various liquid and
ointment fungicides. In many cases the nails are removed entirely, either
temporarily or permanently, depending on the 
severity of the problem. If the nail is
temporarily removed, the doctor directs his treatment to the nail bed and to the
growth center from which the new nail will grow uninfected with fungus. This is
where DMSO works effectively. A paste is made from 30 cc of the 90 percent liquid solvent, with two 250 mg
microsize griseofulvin tablets. Spread the paste into the nail matrix area afterhealing of the nail bed has taken place. Hold the DMSO paste in position with an
adhesive strip and treat the toenails in the same way every day. Newly formed
uninfected toenails should appear from under the flesh in a couple of months
following surgery. Keep putting on the paste for the entire time it takes for the
whole toenail to grow over the nail bed—about six months. Other liquid fungicides may be mixed with DMSO and painted onto the healed
nail bed. Form a puddle under the flap of flesh overiding the toenail growth center. As the nail grows out it will be in continuous touch with the penetrating fungicide,
particularly if a piece of plastic is taped over the toe. The DMSO is itself
fungistatic, so you are treating the problem with two remedies at once. ATHLETE’S FOOT
The medical name for athlete’s foot, 
tinea pedis
, best describes it and its cause. Tinea
 means “fungus” and 
pedis
, “of the foot.” But please realize that “athlete’s
foot” describes the set of symptoms and not the main cause. Fungus by itself does not create the foot disease. Because it is a parasite,
fungus must have the proper medium in which to thrive. The skin of the foot,
encased in a hot shoe, with the heat incubating fungus growth, is that superb
medium. Much as a toadstool lives and grows in topsoil, the fungus lives and
grows on dead skin, such as the dead skin of corns and calluses. It is present on
the feet of hundreds of thousands of people, men more commonly than women,
because women’s shoes are more open and allow the dispersion of the heat
generated in walking. Once a person has been infected, the symptoms show quickly as scaling
between the toes or along the borders of the heels and the longitudinal arches. There is itching and maceration with wrinkling and peeling skin. The sure sign of
athlete’s foot is tiny blisters that appear in groups that may break open, leaving
circular, shiny, red areas underneath. The symptoms are known to recur from warm season to warm season in 80
percent of cases; it is chronic in four out of five infected persons. Still, there is
excellent treatment available in the form of antifungal 
remedies applied to the feet
with DMSO as the carrying vehicle. This solvent penetrates the upper skin layers
and sends the antifungal agent deep into the tissue to kill any fungus on top of or
within the skin. Additionally, DMSO is itself a fungistatic substance that stops
athlete’s foot symptoms by discouraging growth of the pesky parasite. To help yourself get rid of athlete’s foot, the procedure followed by healthprofessionals is to dress the infected skin with the suitable athlete’s foot remedy
for the type of symptoms you’re treating: a cream for sore, exposed skin surfaces;
an ointment for thickened, scaling areas; a liquid for unbroken blisters. Then, cover
this remedy with the matching form of DMSO: cream, gel, or liquid. Use not less
than a 70-percent strength of DMSO for more effective penetrating power. The
condition should disappear in a short time and possibly not recur, especially if you
keep this remedy at hand. FOOT ODOR
Foot odor, one of the most annoying problems, although it is neither painful nor
infectious, is known scientifically as 
bromidrosis. Bromidrosis is not necessarily due to lack of cleanliness. While proper foot
hygiene will help, foot odor is, genuinely, a physiological problem.
Dmso_Nature_s_Healer_-_Morton_Walker.txt
Summarize the following text section accurately and concisely. Maintain specific details and numerical information, and use anti-repetition mechanisms:

        She had shrugged off their
requests, believing that the purported arthritis pain-relieving property of the drug
was just another “quack cure” that would produce additional side effects to make
her life even more unbearable than it already was. THE OFFICIAL POSITION OF THE ARTHRITIS FOUNDATION
Finally, Miss Jackson was swayed by the stand against DMSO taken by the
Arthritis Foundation. Prior statements indicated that its Committee on Unproven
Remedies was opposed to the legalization of the drug in the State of Florida, which
put the Arthritis Foundation in the position of opposition to use of DMSO for
relieving arthritis. Charles C. Bennett, vice president of public and professional education for the
Arthritis Foundation of Atlanta, Georgia, appeared before the House of
Representatives Select Committee on Aging. Mr. Bennett 
said, “The Arthritis
Foundation is not against DMSO. We would be delighted if it were established by
appropriate scientific procedures to be effective. I don’t think the safety question
seems to be a major one. That is pretty clear. But the question of effectiveness for
arthritis, particularly for inflammatory arthritis, particularly for chronic arthritis, is
not clearly resolved. The question [is one] of finding an agent that will deal with
the pain problem in a disease that goes on and/or involves a search for somethingthat works not just for a short-term overnight basis, but in a long-term chronic
use. ”
The Arthritis Foundation thus changed its position, in a way. From
disapproving legislation in 1977 to permit use of DMSO by individual states and
accepting the 
ad hoc
 Committee on Dimethyl Sulfoxide of the National Academy
of Sciences–National Research Council’s negative report, the Arthritis Foundation
has now endorsed it for limited use as a pain reliever. “DMSO is by no means a worthless drug,” Bennett said. “It appears to work as
a local analgesic and therefore might be useful in a host of conditions causing
pain. But there is no scientific proof that it reduces swelling and inflammation
(which are of such critical importance in rheumatoid arthritis, for example), or that
it changes the underlying course of any connective tissue disease. ”
In summary, the Arthritis Foundation told people who have rheumatoid or other
inflammatory arthritis that DMSO was not the drug for them. They needed more
than pain relief; they had to have the inflammation suppressed, something even
aspirin in proper dosage can do, but DMSO can’t, they said. The Foundation officials wanted the FDA to get DMSO approved for lesser
pain problems—without waiting for time-consuming trials needed to clear up
questions about the drug’s usefulness for serious systemic conditions, Bennett
said. He indicated that his organization was taking a neutral stand. He
equivocated. The Mike Wallace television presentation changed Miss Jackson’s thinking
about having the treatment, no matter what official position was held by the
Arthritis Foundation. About a week after the first broadcast she telephoned for an
appointment to see a physician who prescribed DMSO. She arranged
transportation and also borrowed the necessary funds to pay for the treatment. Average charges in the United States for the entire course of DMSO arthritis
therapy under medical supervision, including medication for three months, vary
from one physician to the next depending on what geographical area he practices
in, but it averages 
about $950 for the first week and $700 for the second week, if
it’s needed. The first thing the patient noticed upon entering the doctor’s office was the
smell. It was not the antiseptic aroma of alcohol common to most medical
facilities; it was the pungent odor of garlic. “Pardon our odor. It’s DMSO at
work,” read a sign in the reception room. Miss Jackson was introduced to the standard protocol for arthritis therapy, with
DMSO and diet as the initial part of her program. THE PROTOCOL FOR DMSO ARTHRITIS THERAPY
The DMSO Society of Florida, Inc. , recommends that any patient treated with the
solvent be educated in the full anti-arthritis program of DMSO and diet as well as
receiving direct physician care. The program for Miss Jackson, therefore, was a
learning experience as well as therapy. The doctor acted as teacher. A complete nutritional workup was done, including the prescribing of
megadoses of nutrients, especially pantothenic acid, niacinamide, ascorbic acid,
and other vitamins and minerals in the form of supplements to the diet. A typical
patient with inflamed joints, such as Joanna Jackson, follows the specific protocol
for DMSO arthritis therapy. She consulted with the doctor for an evaluation of her existing health problems. A physical examination was carried out, including a number of clinical tests to
determine the extent of her limitation of motion in the hands, arms, feet, legs, hips,
back, shoulders, neck, and other articulations. Grip strength was measured. She had a basic series of laboratory blood tests and urinalysis performed. An
overly-detailed number of laboratory testings was not done, because as an
arthritic, the patient had already gone through too many examinations, probably
every one in the book. This overtesting for arthritics is an all-too-frequent practice
in most medical establishments. It is a waste of the medical consumer’s money. Miss Jackson did have a sedimentation rate, liver function test, hair analysis,
computerized diet evaluation, and some other checkups. It is important to know what the patient eats, since prior observations of
arthritic people have shown that sugar taken in excess brings on joint symptoms. (I
will have more to say on this topic a little further along in this chapter. ) The
computerized diet evaluation gave the doctor clues as to what nutrition education
was needed. With completion of the pretesting, the entire treatment program was 
explained
to the patient. She was handed the informed consent statement (see 
Figure 7. 1
) to
read and sign in accordance with the official position of the Florida Medical
Association, described in 
Chapter 2. For Miss Jackson, intravenous injection of DMSO using a half dose (0. 5 g/kg
of body weight) was begun the first treatment day. The infusion procedure takes
three or four hours depending on the speed of the fluid flow into the vein. The next
day and for those treatments administered thereafter, the full dose (1. 0 g/kg mixed
into 1,000 cc of fluid) was given. There are five treatment days in a week, extending from Monday to Friday, andone series of a week’s injections usually are sufficient, except for people suffering
with arthritis of the spine. It takes spondylitis patients longer to respond, so that
two weeks of infusions may be required. Although no health insurance policy was reimbursing the patient for the DMSO
arthritis therapy, Miss Jackson financed a second week of treatment herself
because of the improvement she saw developing in her joints. At the start of her
second week of care, she was feeling more comfortable than any time in the recent
past. A tape-recorded treatment room dialogue between the doctor and the patient
went like this:
Doctor:
 Tell me about your progress, Joanna. Jackson:
 I think I’ve improved a lot. Doctor:
 In what areas, specifically. Jackson:
 Well, when your nurse tested my hand grip with that blood
pressure device a few minutes ago, my strength had improved from only
twenty pounds of pressure a week ago to sixty pounds today. Doctor:
 Three times as well; that’s one of the best test results we’ve
had this month. Good progress. Jackson:
 But all my fingers still won’t close in a fist. Doctor:
 Those fingers are quite deformed; they may never fully close. Jackson:
 But now these two close all the way [index finger and third
finger on the right hand] where they didn’t before. Doctor:
 Any other progress to report. Jackson:
 Yes, my feet are better. Doctor:
 How can you tell. Jackson:
 Because I can walk without canes. I can pick my feet up
higher and bend my knees without pain. And my ankles don’t hurt
anymore. I think there’s less arthritis in my leg joints, don’t you. Doctor:
 Yes, if you’re picking up your feet well off the floor, I would
say there’s less inflammation present. And you’ve definitely noticed a
difference when you walk. Jackson:
 I sure have. I can do deep knee bends, where I hadn’t been
able to since I was nine years old. Doctor:
 Be sure to put plastic wrap over your joints below the waist
after you’ve painted them with the solution and place gauze or another
wrapping over that. Leave these coverings on overnight. Sleep with them
on. The skin is quite resistant to skin reactions from DMSO down there. But don’t use Saran or other plastic wrap above the waist because it’s
liable to produce a blistering from the DMSO application under plastic. Jackson:
 I’ve been painting my knees with DMSO and covering with
Saran Wrap. You mean I should do the same to my ankles. For my hands
too. Doctor:
 Do it for your ankles but not for the hands. You mustn’t
occlude the air over DMSO on any joint above the waist, because it will
cause blistering. Scientists don’t know why the skin is more sensitive
above the waist than below. Do paint your finger joints with the liquid—
all you wish, just as you’ve been doing. Consent Form for Arthritis Treatment
 
 
I, __________________, have had explained to me the DMSO form of
arthritis treatment, which includes DMSO intravenously and topically
(applied to the skin), large doses of Vitamin C, enzymes, such as bromelain
from pineapple, and a rigid dietary program. I understand that certain side
effects, such as nausea, depression, or skin rash, may occur. I am aware of the other modes of treatment and I have been advised by
Dr. __________________ to obtain at least one second opinion from a
physician specializing in traditional arthritis therapy. I also understand that
DMSO is not approved by the Federal Food and Drug Administration for
the treatment of arthritis. Lastly, in most cases, DMSO IV therapy is not covered by Medicare or
other forms of insurance. WITNESSES:
__________________  
__________________  
(Signature)
(Signature)
__________________
__________________
(Date)
(Date)
 
Figure 7. 1
 Informed consent statement. I will give a complete description of this plastic impervious wrapping
technique in the next section, but let us finish following Joanna Jackson through
her first week of treatment. She had been taught how to apply the topical DMSO on the first treatment dayand the arthritis diet with its initial supply of supplements was given to her, too. The second day Miss Jackson received a further explanation of the diet. Gentle
passive exercises were given to her and more active ones were demonstrated for
her own exercising at home. The third treatment included a demonstration of how to put on the impervious
wrapping. The nurses also gave lectures on the significance of hair and diet
analyses. Reports in writing about her hair and diet analyses were received by the
patient within ten days of the testings. All the while Miss Jackson was being
evaluated by the doctor during her physical examinations. The fourth treatment day consisted of more IV DMSO and the doctor’s formal
lecture on nutrition. Family and friends were invited to listen to the lecture so that
the patient would receive support at home when she attempted to change her eating
lifestyle. Miss Jackson had 
prescribed for her daily doses of flavored cod liver oil
for its vitamin A, D, and E contents. She applied it topically as well as taking it
orally. At home, the patient was instructed to swallow one teaspoonful of cod liver
oil with lemon juice twice a day to keep her blood level elevated. Cod liver oil
aids the action of DMSO. Also, more passive exercises were given to Miss
Jackson at that visit. On her final visit she went through the entire diagnostic testing again in order to
compare her readings with the baseline record of when she first arrived. Also, if
Miss Jackson had not elected to remain another week, she ordinarily would have
received a three-month supply of DMSO consisting of four bottles of the oral and
two bottles of the topical, with an explanation of when and how to use them. As it
was, at the end of the second week she took home a six-month supply. Every IV treatment procedure was the same. The patient was instructed to eat
a good breakfast each morning before the IV hookup except on the mornings when
blood was to be drawn for testing. Hookup was between 8:00 
A. M
 and 8:30 
A. M
, no
later. She brought a snack to eat during the hours of treatment. There was no
restriction of bathroom privileges, because anybody could go to the toilet carrying
the IV bottle still attached in the vein. One merely needed to hold the IV bottle
high in the opposite hand from the IV needle. The IV needle hand had to be kept
low and be prevented from getting bumped. There was a hook in the bathroom next
to the commode, from which the patient could hang the bottle. THE IMPERVIOUS WRAPPING TECHNIQUE
Keypunch operator Irene A. Brooks of Bradenton, Florida, had horrible left kneepain from osteoarthritis. Her comfort came merely from the application of topical
DMSO under an impervious wrap, the kind of plastic packaging material
commonly employed in the kitchen, for example, Saran Wrap, Glad Wrap, and
Handi Wrap. For three months Mrs. Brooks followed the wrapping procedure
applying it each time her knee flared with pain. Then she felt relief, at least
temporarily. The impervious wrapping technique consists of first putting on the topical
DMSO liquid, gel, cream, or ointment to cover the area of discomfort. Do not rub
in the medication but apply it lightly with the aid of a cotton ball, wooden cotton-
tipped applicator, soft and narrow paintbrush, or just your fingers. Wrap a thin layer of gauze bandage over and around the affected area. Next,
cover the entire bandage and solvent coating with plastic wrap. Leave the impervious wrapping in place for two hours the first time. If no skin
irritation develops, the next time you may leave the wrapping alone for the entire
period you’re sleeping. Or, you may keep it in place during the day. Do not wash the treated area with harsh soaps, other solvents, or household
chemicals that could contribute to skin irritations. The DMSO alone may bring on
a rash or irritation—in which case discontinue the impervious application. The plastic wrap technique may be used for parts of the body below the waist
such as the hips, knees, ankles, feet, or areas in between. Do not use this
procedure for the upper body—the arms, hands, trunk, neck, face, shoulders, or
back. Plastic seems to be too strong for covering areas above the waist and
excludes the air from the DMSO-treated skin. THE DMSO ANTI-ARTHRITIS DIET AND FOOD
SUPPLEMENTS
For any arthritic person daily diet becomes extremely important. The end products
of red meats such as beef, pork, veal, and lamb are particularly antagonistic to
inflamed joints. Consequently, red meat should be eliminated from an arthritic’s
diet at the beginning of treatment and during acute flare-ups. The Clinica Manner (Manner Clinic) Metabolic Research Foundation, P. O. Box 434290, San Ysidro, California 92143-4290, (800) 433-4962 or (800) 248-
8431, recommends the Manner Metabolic Therapy A for use with DMSO. Developed by the late Harold W. Mannner, Ph. D. , former professor of biology and
chairman of the Biology Department of Loyola University of Chicago, MetabolicTherapy A consists of an anti-arthritis diet and various food supplements. For an
overview of the general diet, see 
Table 7. 1
, which presents the foods allowed and
the foods to be avoided while following the DMSO protocol. In addition to recommending that certain foods be avoided, the Foundation also
advises that pesticides, food additives (especially monosodium glutamate, or
MSG, and other additives ending with 
-ate)
, and artificial colors, flavors, and
preservatives be avoided. Furthermore, sugar should be avoided, both by itself and
processed into foods. Prolonged intake of refined sugar (and other refined products) is a major
contributing factor in arthritis. Refined sugar depresses vitamin C stores. The
highest concentration of vitamin C in the body is in the adrenal glands, and chronic
vitamin C deficiency (hypoascorbemia) leads to adrenal exhaustion. With
prolonged adrenal deficiency, there is a deficiency of endogenous (body-produced)
cortisone. Rheumatoid arthritis is the end result of this prolonged attack of sugar
on the adrenal glands. Table 7. 1
 The Manner Clinic Anti-Arthritis Diet
Food
Category
Foods Allowed
Foods to Be Avoided
Beverages
Herb teas (chamomile, mint, papaya; no
caffeine), fresh fruit juice, fresh
vegetable juice, purified water
Alcohol, cocoa, caffeinated
and decaffeinated coffee,
carbonated beverages,
canned and pasteurized
juices, artificial fruit drinks
Dairy
Products
Raw milk, yogurt, butter, buttermilk in
limited quantities, non-fat cottage
cheese, white (Farmer) cheese
All processed and imitation
butter, ice cream, toppings,
all pasteurized cheeses
Eggs
Poached or boiled (one per day)
Fried or scrambled
Fish
Fresh white-fleshed, broiled or baked
Non-white-fleshed, fried or
breaded
Fruit
All dried (unsulfured), stewed, fresh,
frozen (unsweetened)
Canned, sweetened
Grains
Whole grain cereals, bread or muffins
made from rye, oats, wheat, bran,
buckwheat, millet, and other whole
grains; cream of wheat, brown rice,
White flour products, hull-
less grains and seeds such as
pasta, crackers, macaroni,
snack foods, white rice,whole seeds of sesame, pumpkin,
sunflower, flaxseed
prepared or cold cereals,
cooked seeds
Meats
Poultry, but never fried or breaded
All red meat products such
as beef, pork, lamb, veal
Nuts
All fresh, raw nuts
Roasted and/or salted,
especially peanuts
Oils
Cold-processed such as safflower
Shortening, refined fats and
oils (unsaturated as well as
saturated), hydrogenated
margarine or hydrogenated
nut butters
Seasonings
Herbs, garlic, onion, chives, parsley,
marjoram
Pepper, salt, hot spices
Soups
All made from scratch, such as
vegetable, chicken, barley, millet,
brown rice
Canned and creamed
(thickened), commercial
bouillon, fat stock
Sprouts
All, especially wheat, pea, lentil,
alfalfa, and mung
None
Sweets
Raw honey, unsulfured molasses,
carob, unfavored gelatin, pure maple
syrup (in limited amounts)
Refined sugars (white,
brown, turbinado), chocolate,
candy, syrups
Vegetables
All raw and not overcooked, steamed,
fresh or frozen, potatoes baked or
broiled
All canned vegetables, fried
potatoes in any form, corn
chips
“Demon Sugar” is also a major contributing factor in osteoarthritis, also known
as degenerative arthritis. Sugar depresses the blood phosphorus. The blood
calcium and phosphorus are kept in a precise balance by the body when in good
health. Any stress on the body, such as illness or refined sugar intake, will upset
the delicate and extremely important calcium/phosphorus ratio. Depression of the blood phosphorus by refined sugar causes a 
relative
increase in blood calcium. The parathyroid gland, confused by the “low”
phosphorus level, thinks the blood needs more calcium and acts, through the
release of parathyroid hormone, to pull calcium out of the bones. So now there is
even more calcium in the blood. But the body knows that too much calcium in the
blood can cause sudden death so, to protect from hypercalcemia and death, thebody acts in two ways to eliminate this excess calcium. It eliminates the calcium
in the urine and, more germane to our discussion, 
it deposits it in soft tissues, such
as arteries, and in the joints. The prolonged use of refined sugar leads to a veritable army of aggressors
released against your body, resulting in arthritis, arteriosclerosis, diabetes, chronic
infections, and osteoporosis. It’s popular to believe that “you are what you eat,” but this is not entirely
correct. The food must be digested and absorbed into the blood stream before
nutrients can do the body any good. Arthritis is one of the degenerative diseases,
which indicates that digestion is incomplete for ingested materials. The food is
poorly absorbed, so that the body joints are insufficiently nourished. To overcome poor absorption and decrease the stress placed on the gastric
glands and the pancreas, a tablet containing hydrochloric acid, pepsin, and
enterically coated pancreatic enzymes should be taken at each meal. The Manner
Clinic has made such nutritional supplementation a part of its anti-arthritis regime,
and I believe in it also. It ensures the proper digestion of food. Note:
 In some
people excessive gas might follow gastric juice supplementation, which means that
you already have enough hydrochloric acid. In this case, take only tablets
containing the pancreatic enzymes. The Manner Metabolic Therapy A for arthritis also includes the following
supplements:
2,000 mg vitamin C with each meal
400 IU vitamin E with each meal
1,000 mg pantothenic acid with each meal
2 multivitamin capsules after each meal
25,000 IU vitamin A (or 2 teaspoons cod liver oil) twice daily
2,500 IU vitamin D three times daily (including at bedtime)
The amounts to be taken of all of the above supplements can be cut in half
after symptomatic improvement is noticed. Vitamin A should be taken in emulsified form to avoid liver involvement. Up
to 500,000 IU (International Units) of liquid vitamin A have been given without
side effects by physicians practicing metabolic therapy at such places as the
Health and Wellness Center of Minneapolis or the Degenerative Disease Medical
Center of Las Vegas. If emulsified vitamin A is not available, I recommend instead
that you consider using for a few days 50,000 to 100,000 IU of regular vitamin A. Note:
 Observe your skin. If drying or scaling occurs, discontinue vitamin A for
one week. If any other signs of vitamin A toxicity, such as headaches, hair
changes, or dryness of the mouth, occur, discontinue the vitamin A for a week and
resume with a reduced dosage the following week. Continue with a half-dose daily
with a two-week-on one-week-off routine. Symptoms of vitamin A toxicity
disappear as soon as you reduce your daily dosage. Vitamin C is quite necessary for an arthritic, and megadoses ranging up to 15 g
should be taken daily, according to the Manner Clinic. I suggest a somewhat lesser
amount, at least to start. Make sure the vitamin C is in the form of ascorbates,
which have a neutral pH (acid-base balance) and, therefore, prevent problems with
acidity. Also, ascorbates contain the bioflavonoids that are necessary for the
proper metabolism of this vitamin. Note:
 Megadoses of ascorbic acid may cause
gastric disturbances such as diarrhea. Acute diarrhea will indicate the body’s
tolerance level has been reached, and you should reduce your dose until diarrhea
no longer is a problem. A therapeutic vitamin-mineral supplement should be taken morning and
evening as well. The tablets or capsules can be swallowed with a Protein Milk
Shake, which the Foundation also recommends (see 
here
). In addition to the supplements already mentioned, also recommended on a
daily basis are 3 g of calcium, one-quarter pound fresh liver or 15 liver tablets,
fresh wheat germ, and 6 tablespoons bran (on morning cereal). A superoxide
dismutase (SOD) supplement is also encouraged. Recent laboratory work has
indicated that people suffering from arthritic or rheumatic diseases have a
decreased amount of SOD in their circulating blood. SOD is a metalloprotein, a
natural enzyme. To overcome an SOD deficiency, a tablet or two containing the
enzyme could be taken with each meal. Such a supplement will have an anti-
arthritic effect. The anti-arthritic diet and supplement regime may be begun with a two-day
juice fast, which is recommended by the Manner Clinic. To allow for taste
acclimation to juices, a blend of 50 percent apple and 50 percent carrot juice
should be taken first. As rapidly as possible, eliminate the apple juice and add
other vegetable juices to the carrot juice. This is a way to ease into drinking
celery, beet, potato, and other vegetables as juices. Definitely don’t drink canned
juices, since the heat of canning destroys the vegetable enzymes. Prepare and drink
the juice each day to prevent oxidation of the liquid, and eat nothing solid for two
days. Protein Milk Shake
 
2 eggs
1
⁄
4
 cup yogurt
4 teaspoons calcium gluconate
1 tablespoon lecithin
1 tablespoon safflower oil
1 teaspoon granular kelp
1
⁄
2
 teaspoon magnesium oxide
4 cups skim milk
1
⁄
2
 cup powdered non-instant milk
1
⁄
4
 cup yeast fortified with calcium
1
⁄
4
 cup soy flour or powder
1
⁄
4
 cup wheat germ
1 teaspoon vanilla (not vanillin)
In blender, thoroughly mix eggs, yogurt, calcium gluconate, lecithin,
safflower oil, kelp, and magnesium oxide. Add 2 cups skim milk, powdered
milk, yeast, soy flour, wheat germ, and vanilla, and mix. Add remaining 2
cups skim milk, plus fruit or fruit juice, carob, honey, additional vanilla, or
other flavoring to taste, if desired. Drink two-thirds of a cup six times a
day (with each meal and at midmorning, midafternoon, and bedtime). Follow the anti-arthritis diet and take the food supplements while you are
under treatment with DMSO. Continue on this diet as part of your lifestyle
thereafter. And absolutely avoid refined sugar in any form. DETOXIFICATION
A process of detoxification goes along with the anti-arthritis diet and
supplementation program. Each day a coffee enema could be administered. (It’s
the only useful purpose for coffee. ) Cool one cup of brewed (non-instant) coffee tobody temperature and introduce it into the rectum with a rectal syringe. Retain the
coffee for fifteen to thirty minutes. The caffeine-stimulated secretion of bile is an
important part of the detoxification plan, as it helps to restore the alkaline
condition of the small intestine. Continue colonic irrigation with coffee enemas until the bowel movements
become regular, twice a day if possible. Part of the arthritic’s problem is that he or
she does not get rid of toxic products catabolyzed by the body. The bowel habits
are irregular. Drinking four to eight glasses of freshly prepared vegetable juices
also helps to bring bowel movements back to normal. THE MANNER COCKTAIL FOR ARTHRITIS
The Manner Clinic utilizes what it calls the Manner Cocktail for the permanent
relief of various forms of arthritis including tendinitis, gouty arthritis, bursitis,
rheumatoid arthritis, and osteoarthritis; chronic back disorders; and acute sprains
and strains. The cocktail consists of a combination of vitamin C, amygdalin, and
DMSO. It was developed by Dr. Manner around 1987 to act as a chelating agent,
which grabs metallic ions out of the body, and to enhance electron density at the
oxygen atom and the steric availability of the oxygen, which increases the packing
of the oxygen atoms so that more oxygen is present to nourish the cells. Being both anti-inflammatory and analgesic (causing the reduction of pain) in
its action, the DMSO infusion is exceedingly useful for the correction of arthritis
and its many complications. To learn more about the administration of DMSO via
the Manner Cocktail, contact the Manner Clinic. REPORTED ARTHRITIS-DMSO INVESTIGATIONS
In 1989, five Italian physicians investigated the complications and symptoms of
rheumatoid arthritis and tested the efficacy of dimethyl sulfoxide on the overall
condition. Writing in the journal 
Minerva Medica
, the doctors concluded: “In this
study we have investigated the role of oral dimethylsulfoxide (DMSO) therapy in
two patients with primary amyloidosis (AL) [a form of rheumatoid arthritis] with
secondary amyloidosis (AA) to long-standing rheumatoid arthritis. DMSO
treatment produced no beneficial effects in the patients with idiopathic [cause
unknown] amyloidosis. Instead the patients with secondary amyloidosis
experienced a subjective improvement, a decrease of inflammatory activity of therheumatoid arthritis, and an unequivocal improvement of renal [kidney] function
following three to six months of DMSO therapy. No serious side effects of DMSO
were observed except for unpleasant breath odour. We conclude that a treatment
with oral DMSO may prolong life of patients with secondary amyloidosis. ”
1
With acute gouty arthritis in a 1981 Russian study, DMSO was administered
for the condition and compared to indomethacin, a drug therapy. The DMSO
treatment was more effective for gout. 2
Favorable effects for juvenile rheumatoid arthritis were reported in a case, in
1984, when DMSO was administered to a girl with secondary amyloidosis as a
complication of her arthritis. Dimethyl sulfoxide was applied by topical
application to the skin. The young girl’s gastrointestinal symptoms and massive
proteinuria (protein in the urine) improved. Her decreased left ventricular function
of the heart and her kidney’s creatinine clearance also improved remarkably. The
ten collaborating Japanese physicians on this case came to the conclusion, “The
favorable effect of dimethyl sulfoxide in this single patient deserves further study
in a controlled trial. ”
3
Two Russian orthopedists used DMSO to treat rheumatoid arthritis without
complications, as published in their 1981 case report. 4
Another group of Russian doctors in 1983 investigated DMSO for the
treatment of rheumatoid arthritis and compared its effect to colchicine. DMSO was
more advantageous and produced no kidney complications. 5
Ordinarily Still’s disease is a chronic arthritis developing in children before the
age of sixteen. There are several different forms of arthritis affecting children, and
some authorities confine the diagnosis of Still’s 
disease to the following: a disease
of childhood marked by arthritis (often involving several joints) with a swinging
fever and a transitory red rash. There is often severe illness affecting the entire
body and the condition may be complicated by enlargement of the spleen and
lymph nodes and inflammation of the pericardium (heart muscle) and iris of the
eye. But seven Japanese clinical investigators reported on DMSO usage for a case
of Still’s disease in a thirty-seven-year-old man with the adult-onset variety. He
suffered from severe diarrhea. The Japanese doctors’ viewing of the patient’s upper and lower gastrointestinal
tract by means of endoscopy revealed swollen mucosa with white patches,
erosions, bleeding, and amyloid deposits. As previously defined, amyloid is a
glycoprotein, resembling starch, that is deposited in the internal organs in the
presence of the pathological condition amyloidosis. Amyloidosis is infiltration ofthe liver, kidneys, spleen, and other tissues with amyloid. The clinicians took
biopsy specimens from the man’s bowel. After they administered three months of therapy with DMSO and prednisolone,
improvement in the endoscopic appearance of the patient’s gastrointestinal tract
was observed. Amyloid deposits in the biopsy specimens were reduced in the
stomach and appeared totally negative in the large intestine. Their patient had a
successful recovery from the use of DMSO. 6
The author of 
Malpractice
 and 
Confessions of a Medical Heretic
, Robert S. Mendelsohn, M.
She shrugged off their requests, believing the pain-relieving property of the drug was just another "quack cure" that would cause additional side effects to make her life even more unbearable.
What was Miss Jackson's initial reaction to the requests to try the DMSO treatment?
The Mike Wallace television presentation changed her thinking about having the treatment.
What changed Miss Jackson's thinking about having the treatment?
The Arthritis Foundation initially disapproved the use of DMSO, but later changed its stance and endorsed it for limited use as a pain reliever.
What is the Arthritis Foundation's official stance on the use of DMSO?
The impervious wrapping technique is used to enhance the effectiveness of the treatment by allowing the DMSO to penetrate the skin more easily.
What is the purpose of the impervious wrapping technique in the treatment of arthritis?
The recommended treatment for ingrown toenails involves the use of DMSO as a carrying vehicle to deliver an antifungal agent to the affected area, and the application of a fungistatic substance to the infected skin.
What is the recommended treatment for ingrown toenails?