Surrender
"Know when to hold 'em, Know when to fold 'em" are lyrics from a famous Kenny Rogers song, and they apply to life in so many ways.  When do you give up?  When do you throw up your hands and let things take their course, despite being unhappy with the state of it all?
surrender know hold them know fold them lyric famous kenny rogers song apply life way     throw hand let thing co USA  despite unhappy state