Daxxify
Generic name: daxibotulinumtoxinA-lanm
Dosage form: lyophilized powder for injection
Drug class: Skeletal muscle relaxants
What is Daxxify?
Daxxify is a prescription medicine for adults that is injected into muscles to temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines).
Daxxify is a botulinum toxin product that works by inhibiting the transmission of specific chemical signals from nerves, primarily those signals that cause muscular contractions. It works by temporarily relaxing the facial muscles that cause wrinkles between the eyebrows, reducing their appearance.
What is Daxxify used to treat?
Daxxify is used to help smooth moderate to severe lines between the eyebrows.
It is formulated to be a long-lasting frown line treatment, lasting on average 6 months, and up to 9 months in some.
It is not known if Daxxify is safe and effective in children less than 18 years of age.
Important information
Daxxify may cause serious side effects that can be life threatening. Call your healthcare provider or get medical help right away if you have any of these problems after treatment:
Problems swallowing, speaking, or breathing. These problems can happen hours, days, or weeks after an injection of Daxxify if the muscles that you use to breathe and swallow become weak after the injection. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment.
- People with certain breathing problems may need to use muscles in their neck to help them breathe. These people may be at greater risk for serious breathing problems with Daxxify.
- Swallowing problems may last for several months. People who cannot swallow well may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving Daxxify have the highest risk of getting these problems.
Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include:
- loss of strength and muscle weakness all over the body
- blurred vision and drooping eyelids
- trouble saying words clearly
- trouble breathing
- double vision
- hoarseness or change or loss of voice
- loss of bladder control
- trouble swallowing
These symptoms can happen hours, days, or weeks after you receive an injection of Daxxify.
These problems could make it unsafe for you to drive a car or do other dangerous activities. See What should I avoid while receiving Daxxify?
Although no serious adverse reactions of distant spread of toxin effect associated with Daxxify have been reported in clinical studies of 40 Units for glabellar lines, these reactions are possible.
Who should not receive Daxxify?
You should not receive Daxxify if you:
- are allergic to Daxxify or any of the other ingredients. See the end of this page for a list of ingredients.
- had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (Myobloc), onabotulinumtoxinA (Botox, Botox Cosmetic), abobotulinumtoxinA (Dysport), incobotulinumtoxinA (Xeomin) or prabotulinumtoxinA-xvfs (Jeuveau).
- have a skin infection at the planned injection site.
Before receiving Daxxify
Before receiving Daxxify, tell your healthcare provider about all of your medical conditions, including if you:
- have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert-Eaton syndrome). See Important information.
- have had any side effect from any other botulinum toxin in the past
- have or have had a breathing problem, such as asthma or emphysema
- have or have had swallowing problems
- have or have had heart problems
- have or have had bleeding problems
- have weakness of your forehead muscles, such as trouble raising your eyebrows
- have drooping eyelids
- plan to have surgery
- have had surgery on your face
- have had dry eye problems with the use of botulinum toxin products in the past
- are pregnant or plan to become pregnant. It is not known if Daxxify can harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if Daxxify passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.
What other drugs will affect Daxxify?
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
Using Daxxify with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your healthcare provider that you have received Daxxify in the past.
Especially tell your healthcare provider if you:
- have received any other botulinum toxin product in the last 4 months.
- have received injections of botulinum toxin such as rimabotulinumtoxinB (Myobloc), onabotulinumtoxinA (Botox, Botox Cosmetic), abobotulinumtoxinA (Dysport), prabotulinumtoxinA (Jeuveau) and incobotulinumtoxinA, (Xeomin) in the past. Be sure your healthcare provider knows exactly which product you received.
Know the medicines you take. Keep a list of your medicines with you to show your healthcare provider and pharmacist each time you get a new medicine.
How will I receive Daxxify?
- Daxxify is an injection that your healthcare provider will give you.
- Daxxify is injected into your affected muscles.
Your healthcare provider may change your dose until you and your healthcare provider find the best dose for you. - Daxxify should not be received more than 1 time every 3 months.
- Your healthcare provider will tell you how often you will receive your dose of Daxxify injections.
Dosing information
Usual Adult Dose for Glabellar Lines:
- 0.1 mL (8 Units) by intramuscular injection into each of five sites, for a total dose of 40 Units.
Use: temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients.
What should I avoid while receiving Daxxify?
Daxxify may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of receiving Daxxify. If this happens, do not drive a car, operate machinery, or do other dangerous activities. See Important information.
Daxxify side effects
Daxxify may cause serious side effects, including:
- See Important information.
- Heart problems. Irregular heartbeat and heart attack that have resulted in death, have happened in some people who received botulinum toxin products.
- Eye problems. Dry eye, reduced blinking, and corneal problems have happened in some people who receive Daxxify to treat glabellar lines. Tell your healthcare provider if you develop eye pain or irritation, sensitivity to light, or changes in your vision.
- Allergic reactions. Symptoms of an allergic reaction may include: itching, rash, redness, swelling, wheezing, trouble breathing, or dizziness or feeling faint. Tell your healthcare provider or get medical help right away if you have wheezing or trouble breathing, or if you feel dizzy or faint.
The most common side effects include:
- headache
- eyelid drooping
- loss of the ability to move the muscles in your face
These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effect to Revance Therapeutics, Inc. at 1-877-373-8669.
General information about Daxxify.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.
What are the ingredients in Daxxify?
Active ingredient: daxibotulinumtoxinA-lanm
Inactive ingredients: L-histidine, L-histidine-HCl monohydrate, polysorbate 20, RTP004 peptide, trehalose dihydrate
References
More about Daxxify (daxibotulinumtoxinA)
Check interactions
Drug images
Side effects
Dosage information
During pregnancy
FDA approval history
Drug class: skeletal muscle relaxants
Patient resources
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.