Primary myelofibrosis
Primary myelofibrosis (PMF) is a rare bone marrow blood cancer. It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which there is growth of abnormal cells in the bone marrow. This is most often associated with a somatic mutation in the JAK2, CALR, or MPL gene markers. In PMF, the healthy marrow is replaced by scar tissue (fibrosis), resulting in a lack of production of normal blood cells. Symptoms include anemia, increased infection and an enlarged spleen (splenomegaly).

In 2016, prefibrotic primary myelofibrosis was formally classified as a distinct condition that progresses to overt PMF in many patients, the primary diagnostic difference being the grade of fibrosis.
Q546523
bone marrow
Concept
Q2509220
blood cancer
Concept
Q1898104
myeloproliferative neoplasm
Concept
Q546523
bone marrow
Concept
Q2215243
somatic mutation
Concept
Q14914514
JAK2
Concept
Q634510
CALR
Concept
Q18029261
MPL
Concept
Q605709
fibrosis
Concept
Q1129121
splenomegaly
Concept
Q18557834
prefibrotic primary myelofibrosis
Concept
Q605709
fibrosis
Concept
Q1752571
Primary myelofibrosis
Concept
2016-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2016
DATE
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
genetic association
genetic association
anatomical location