Threonine—tRNA ligase
In enzymology, a threonine-tRNA ligase () is an enzyme that catalyzes the chemical reaction

:ATP + L-threonine + tRNA(Thr) formula_1 AMP + diphosphate + L-threonyl-tRNA(Thr)

The three substrates of this enzyme are ATP, L-threonine, and threonine-specific transfer RNA [tRNA(Thr)], whereas its three products are AMP, diphosphate, and L-threonyl-tRNA(Thr).

The systematic name of this enzyme class is L-threonine:tRNAThr ligase (AMP-forming). Other names in common use include threonyl-tRNA synthetase, threonyl-transfer ribonucleate synthetase, threonyl-transfer RNA synthetase, threonyl-transfer ribonucleic acid synthetase, threonyl ribonucleic synthetase, threonine-transfer ribonucleate synthetase, threonine translase, threonyl-tRNA synthetase, and TARS.

Threonine—tRNA ligase (TARS) belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in tRNA and related compounds. More precisely, it belongs to the family of the aminoacyl-tRNA synthetases. These latter enzymes link amino acids to their cognate transfer RNAs (tRNA) in aminoacylation reactions that establish the connection between a specific amino acid and a nucleotide triplet anticodon embedded in the tRNA. During their long evolution, some of these enzymes have acquired additional functions, including roles in RNA splicing, RNA trafficking, transcriptional regulation, translational regulation, and cell signaling.
Q8047
enzymology
Concept
Q8047
enzyme
Concept
Q82264
catalyzes
Concept
Q36534
chemical reaction
Concept
Q12119506
substrates
Concept
Q80863
ATP
Concept
Q186521
L-threonine
Concept
Q201448
transfer RNA
Concept
Q542929
products
Concept
Q318369
AMP
Concept
Q55506489
diphosphate
Concept
Q1255355
systematic name
UNK
Q410221
ligase
Concept
Q415968
aminoacyl-tRNA synthetase
Concept
Q201448
transfer RNA
Concept
Q8066
amino acid
Concept
Q28745
nucleotide
Concept
Q201448
anticodon
Concept
Q237218
RNA splicing
Concept
Q3787274
transcriptional regulation
Concept
Q3455905
translational regulation
UNK
Q210973
cell signaling
Concept
Q7778162
Threonine—tRNA ligase
Concept
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
subclass of
subclass of
molecular function
subclass of