Sodium- and chloride-dependent glycine transporter 2
Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the "SLC6A5" gene.

The glycine transporter 2 is a membrane protein which recaptures glycine, a major inhibitory transmitter in the spinal cord and brainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl−-coupled transporter family SLC6. Glycine uptake mediated by GlyT2 is electrogenic, coupled to three Na+ and one Cl− (i.e. two positive charges per glycine). In humans, GlyT2 is encoded by the "SLC6A5" gene. Inactivation of GlyT2 in knockout mice is lethal during the second post-natal week as the absence of GlyT2 disrupts inhibitory transmission by reducing glycine release. Mutations in SLC6A5 gene are responsible for a presynaptic form of hyperekplexia, a genetic disease causing increased startle reflex. GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration in the presynaptic neuron. Therefore, chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic vesicles.
Q8054
protein
Concept
Q7187
gene
Concept
Q620730
glycine
Concept
Q9606
spinal cord
Concept
Q182228
brainstem
Concept
Q7187
gene
Concept
Q668642
knockout
Concept
Q1781802
hyperekplexia
Concept
Q430986
startle
Concept
Q18033875
Sodium- and chloride-dependent glycine transporter 2
Concept
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
instance of
instance of
encodes