Phosphopantothenate—cysteine ligase
In enzymology, a phosphopantothenate-cysteine ligase also known as phosphopantothenoylcysteine synthetase (PPCS) is an enzyme that catalyzes the chemical reaction which constitutes the second of five steps involved in the conversion of pantothenate to Coenzyme A. The reaction is:

:NTP + (R)-4'-phosphopantothenate + L-cysteine formula_1 NMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

The nucleoside triphosphate (NTP) involved in the reaction varies from species to species. Phosphopantothenate—cysteine ligase from the bacterium "Escherichia coli" uses cytidine triphosphate (CTP) as an energy donor, whilst the human isoform uses adenosine triphosphate (ATP).
Q8047
enzymology
Concept
Q8047
enzyme
Concept
Q82264
catalyzes
Concept
Q36534
chemical reaction
Concept
None
second of five steps
UNK
Q179894
pantothenate
Concept
Q407635
Coenzyme A
Concept
Q418533
nucleoside triphosphate
UNK
Q25419
Escherichia coli
Concept
Q409648
cytidine triphosphate
Concept
Q609809
isoform
Concept
Q80863
adenosine triphosphate
Concept
Q21134457
Phosphopantothenate—cysteine ligase
Concept
-4^^http://www.w3.org/2001/XMLSchema#decimal
-4
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
-4^^http://www.w3.org/2001/XMLSchema#decimal
-4
NUMBER
molecular function
found in taxon
found in taxon