Mexazolam
Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. Its principal active metabolites are chlordesmethyldiazepam (also known as chloronordiazepam or delorazepam, trade name Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan).
Q83871
benzodiazepine
Concept
Q269829
placebo
Concept
Q380409
benzodiazepine tolerance
Concept
Q424440
CYP3A4
MISC
Q954845
HMG-CoA reductase inhibitors
Concept
Q670131
simvastatin
Concept
Q670131
simvastatin acid
Concept
Q417740
lovastatin
Concept
Q417942
fluvastatin
Concept
Q668093
atorvastatin
Concept
Q423439
cerivastatin
Concept
Q1240093
pravastatin
Concept
Q3705147
delorazepam
Concept
Q408265
lorazepam
Concept
Q6148446
Mexazolam
UNK
Q6148446
Mexazolam
UNK
Q6148446
Mexazolam
UNK
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NUMBER
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