Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.

SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the presynaptic cell. They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having strong affinity for the serotonin transporter and only weak affinity for the norepinephrine and dopamine transporters.

SSRIs are the most widely prescribed antidepressants in many countries. The efficacy of SSRIs in mild or moderate cases of depression has been disputed and may be outweighed by side effects, especially in adolescent populations.
Q2976049
class of drugs
Concept
Q76560
antidepressant
Concept
Q42844
major depressive disorder
Concept
Q544006
anxiety disorder
Concept
Q5571762
extracellular
UNK
Q162657
neurotransmitter
Concept
Q167934
serotonin
Concept
Q4859664
limiting
Concept
Q22290476
reabsorption
UNK
Q2643251
presynaptic cell
Concept
Q5692421
monoamine transporter
UNK
Q410142
serotonin transporter
Concept
Q14874257
norepinephrine
Concept
Q2271947
dopamine transporter
Concept
Q334477
Selective serotonin reuptake inhibitor
Concept
instance of
subclass of
instance of
medical condition treated
instance of