Alpha-thalassemia
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes "HBA1" and "HBA2". Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. Normal hemoglobin consists of two alpha chains and two beta chains; in alpha-thalassemia, there is a quantitative decrease in the amount of alpha chains, resulting in fewer normal hemoglobin molecules. Furthermore, alpha-thalassemia leads to the production of unstable beta globin molecules which cause increased red blood cell destruction. The degree of impairment is based on which clinical phenotype is present (how many genes are affected).
Q185137
thalassemia
Concept
Q15328081
HBA1
Concept
Q1417916
HBA2
Concept
Q200779
inherited
Concept
Q6622158
blood conditions
UNK
Q43041
hemoglobin
Concept
Q4735158
alpha chain
UNK
Q424422
beta chains
MISC
Q37187
red blood cell
Concept
Q104053
phenotype
Concept
Q288714
Alpha-thalassemia
Concept
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
subclass of
genetic association
encodes