XCL1
Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the C chemokine family that is also known as lymphotactin. Chemokines are known for their function in inflammatory and immunological responses. This family C chemokines differs in structure and function from most chemokines. There are only two chemokines in this family and what separated them from other chemokines is that they only have two cysteines; one N-terminal cysteine and one cysteine downstream. These both are called Lymphotactin, alpha and beta form, and claim special characteristics only found between the two. Lymphotactins can go through a reversible conformational change which changes its binding shifts. 
In normal tissues, XCL1 is found in high levels in spleen, thymus, small intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Secretion of XCL1 is responsible for the increase of intracellular calcium in peripheral blood lymphocytes. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. NK cells also secrete XCL1 along with other chemokines early in infections. XCR1 expressing dendritic cells (DC) are a major target of XCL1.

In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1. Both of these chemokines share many genetic and functional similarities; however XCL2 has only been known to be observed in humans and not in mice. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1. XCL1 is expressed on macrophages, fibroblasts, and specific lymphocytes.

LTN, is found in two states: a monomer at 10 °C, LTN10, and a dimer at 40 °C, LTN40.
Q212354
cytokine
Concept
Q421866
chemokine
Concept
Q9371
spleen
Concept
Q163987
thymus
Concept
Q11090
small intestine
Concept
Q42395
leukocyte
Concept
Q7886
lung
Concept
Q9625
prostate gland
Concept
Q9631
ovary
Concept
Q193529
T cell
Concept
Q332181
NK cells
MISC
Q506253
dendritic cell
Concept
Q8041712
XCL2
Concept
Q7187
gene
Concept
Q106227
locus
Concept
Q430258
chromosome 1
LOC
Q24720618
chemokine receptor
Concept
Q14911554
XCR1
UNK
Q184204
macrophages
Concept
Q463418
fibroblasts
Concept
Q715347
lymphocytes
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
Q8041711
XCL1
Concept
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+8^^http://www.w3.org/2001/XMLSchema#decimal
8
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+10^^http://www.w3.org/2001/XMLSchema#decimal
10
NUMBER
+10^^http://www.w3.org/2001/XMLSchema#decimal
10
NUMBER
+40^^http://www.w3.org/2001/XMLSchema#decimal
40
NUMBER
+40^^http://www.w3.org/2001/XMLSchema#decimal
40
NUMBER
instance of
chromosome
subclass of
instance of
chromosome