Asparaginase
Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL). It is given by injection into a vein, muscle, or under the skin. A pegylated version is also available. In food manufacturing it is used to decrease acrylamide.
Common side effects when used by injection include allergic reactions, pancreatitis, blood clotting problems, high blood sugar, kidney problems, and liver dysfunction. Use in pregnancy may harm the baby. As a food it is generally recognized as safe. Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.
Asparaginase was approved for medical use in the United States in 1978. It is on the World Health Organization's List of Essential Medicines. It is often made from "Escherichia coli" or "Erwinia chrysanthemi".
Q8047
enzyme
Concept
Q627371
food manufacturing
Concept
Q180664
acute lymphoblastic leukemia
Concept
Q640448
injection into a vein
Concept
Q432083
muscle
Concept
Q2035485
under the skin
Concept
Q682252
pegylated
UNK
Q342939
acrylamide
Concept
Q42982
allergic reactions
Concept
Q1527888
pancreatitis
Concept
Q476921
kidney problems
Concept
Q929737
liver dysfunction
Concept
Q11995
pregnancy
Concept
Q1041116
generally recognized as safe
Concept
Q8066
amino acid
Concept
Q185906
asparagine
Concept
Q8054
protein
Concept
Q37155
World Health Organization's List of Essential Medicines
MEDIA
Q25419
Escherichia coli
Concept
Q3026652
Erwinia chrysanthemi
Concept
Q105296036
Asparaginase
UNK
Q105296036
Asparaginase
UNK
Q105296036
Asparaginase
UNK
1978-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
1978
DATE
found in taxon
found in taxon
subclass of
part of