ATG5
Autophagy related 5 (ATG5) is a protein that, in humans, is encoded by the "ATG5" gene located on Chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-I (microtubule-associated proteins 1A/1B light chain 3B) conjugation to PE (phosphatidylethanolamine) to form LC3-II (LC3-phosphatidylethanolamine conjugate). ATG5 can also act as a pro-apoptotic molecule targeted to the mitochondria. Under low levels of DNA damage, ATG5 can translocate to the nucleus and interact with survivin.

ATG5 is known to be regulated via various stress induced transcription factors and protein kinases.
Q8054
protein
Concept
Q7187
gene
Concept
Q540857
Chromosome 6
MISC
Q407111
ubi
Concept
None
autophagic cell death
UNK
Q18035460
ATG7
MISC
Q18033863
ATG12
MISC
Q4654662
ATG16L1
MISC
Q18047076
LC3-I
MISC
Q426095
PE
Concept
Q39572
mitochondria
Concept
Q210538
DNA damage
Concept
Q906904
survivin
Concept
Q18034312
ATG5
MISC
Q18034312
ATG5
MISC
Q18034312
ATG5
MISC
Q18034312
ATG5
MISC
Q18034312
ATG5
MISC
Q18034312
ATG5
MISC
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+7^^http://www.w3.org/2001/XMLSchema#decimal
7
NUMBER
+12^^http://www.w3.org/2001/XMLSchema#decimal
12
NUMBER
+16^^http://www.w3.org/2001/XMLSchema#decimal
16
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
instance of
chromosome
encodes
instance of
chromosome