GJA1
Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the "GJA1" gene on chromosome 6. As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and differentiation. As a result of its function, GJA1 is implicated in many biological processes, including muscle contraction, embryonic development, inflammation, and spermatogenesis, as well as diseases, including oculodentodigital dysplasia (ODDD), heart malformations, and cancers.
Q8054
protein
Concept
Q7187
gene
Concept
Q423489
connexin
Concept
Q232438
gap junction
Concept
Q210973
intercellular communication
Concept
Q7868
cell
Concept
Q2383867
cell death
Concept
Q189101
proliferation
Concept
Q210861
differentiation
Concept
Q127006
muscle contraction
Concept
Q3052119
embryonic
MEDIA
Q101991
inflammation
Concept
Q36961
spermatogenesis
UNK
Q12136
disease
Concept
Q17148148
oculodentodigital dysplasia
Concept
Q12078
cancer
Concept
Q15330556
GJA1
MISC
Q15330556
GJA1
MISC
Q15330556
GJA1
MISC
Q15330556
GJA1
MISC
-1^^http://www.w3.org/2001/XMLSchema#decimal
-1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+43^^http://www.w3.org/2001/XMLSchema#decimal
43
NUMBER
+43^^http://www.w3.org/2001/XMLSchema#decimal
43
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
instance of
genetic association
encodes
instance of
subclass of
genetic association