Frontotemporal dementia
Frontotemporal dementia (FTD), or frontotemporal degeneration disease, or frontotemporal neurocognitive disorder, encompasses several types of dementia involving the frontal and temporal lobes. FTDs are broadly presented as behavioral or language disorders. The three main subtypes or variant syndromes are a behavioral variant (bvFTD) previously known as "Pick's disease", and two variants of primary progressive aphasia –
semantic variant (svPPA), and nonfluent variant (nfvPPA). Two rare distinct subtypes of FTD are neuronal intermediate filament inclusion disease (NIFID), and basophilic inclusion body disease. Other related disorders include corticobasal syndrome and FTD with amyotrophic lateral sclerosis (ALS) "FTD-ALS" also called "FTD-MND".

Frontotemporal dementias are mostly early-onset syndromes that are linked to frontotemporal lobar degeneration (FTLD), which is characterized by progressive neuronal loss predominantly involving the frontal or temporal lobes, and a typical loss of more than 70% of spindle neurons, while other neuron types remain intact.

FTD was first described by Arnold Pick in 1892 and was originally called "Pick's disease", a term now reserved only for behavioral variant FTD which shows the presence of Pick bodies and Pick cells. Second only to Alzheimer's disease (AD) in prevalence, FTD accounts for less than, or actually, 20% ("number is perhaps rounded") of degenerative dementia cases found at autopsy.

Signs and symptoms typically manifest in late adulthood, more commonly between the ages of 45 and 65, approximately equally affecting men and women.

Common signs and symptoms include significant changes in social and personal behavior, apathy, blunting of emotions, and deficits in both expressive and receptive language. Currently, there is no cure for FTD, but there are treatments that help alleviate symptoms.
Q83030
dementia
Concept
Q749520
frontal
Concept
Q744385
temporal lobe
Concept
Q18767
primary progressive aphasia
Concept
Q18587
semantic variant
Concept
Q18583
nonfluent variant
Concept
Q55346059
corticobasal syndrome
UNK
Q206901
amyotrophic lateral sclerosis
Concept
Q206901
MND
Concept
Q18579
frontotemporal lobar degeneration
Concept
Q43054
neuron
Concept
Q749520
frontal
Concept
Q744385
temporal lobe
Concept
Q2384084
spindle neuron
Concept
Q695970
Arnold Pick
PER
Q11081
Alzheimer's disease
Concept
Q719602
prevalence
Concept
Q18592
Frontotemporal dementia
Concept
Q18592
Frontotemporal dementia
Concept
1892-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
1892
DATE
+70^^http://www.w3.org/2001/XMLSchema#decimal
70
NUMBER
+20^^http://www.w3.org/2001/XMLSchema#decimal
20
NUMBER
+45^^http://www.w3.org/2001/XMLSchema#decimal
45
NUMBER
+65^^http://www.w3.org/2001/XMLSchema#decimal
65
NUMBER
subclass of
symptoms and signs
subclass of