SLC46A3
Solute carrier family 46 member 3 (SLC46A3) is a protein that in humans is encoded by the SLC46A3 gene. Also referred to as FKSG16, the protein belongs to the major facilitator superfamily (MFS) and SLC46A family. Most commonly found in the plasma membrane and endoplasmic reticulum (ER), SLC46A3 is a multi-pass membrane protein with 11 α-helical transmembrane domains. It is mainly involved in the transport of small molecules across the membrane through the substrate translocation pores featured in the MFS domain. The protein is associated with breast and prostate cancer, hepatocellular carcinoma (HCC), papilloma, glioma, obesity, and SARS-CoV. Based on the differential expression of SLC46A3 in antibody-drug conjugate (ADC)-resistant cells and certain cancer cells, current research is focused on the potential of SLC46A3 as a prognostic biomarker and therapeutic target for cancer. While protein abundance is relatively low in humans, high expression has been detected particularly in the liver, small intestine, and kidney.
Q8054
protein
Concept
Q7187
gene
Concept
Q1886097
major facilitator superfamily
Concept
Q29548
plasma membrane
Concept
Q79927
endoplasmic reticulum
Concept
Q424204
multi-pass membrane protein
Concept
Q283399
α-helical
Concept
Q7834587
transmembrane domain
Concept
Q898273
domain
Concept
Q128581
breast
Concept
Q181257
prostate cancer
Concept
Q1148337
hepatocellular carcinoma
Concept
Q912796
papilloma
Concept
Q1365309
glioma
Concept
Q12174
obesity
Concept
Q85438966
SARS-CoV
Concept
Q1069596
antibody-drug conjugate
Concept
Q1069330
biomarker
Concept
Q9368
liver
Concept
Q11090
small intestine
Concept
Q9377
kidney
Concept
Q18054152
SLC46A3
Concept
Q18054152
SLC46A3
Concept
Q18054152
SLC46A3
Concept
Q18054152
SLC46A3
Concept
Q18054152
SLC46A3
Concept
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+16^^http://www.w3.org/2001/XMLSchema#decimal
16
NUMBER
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+11^^http://www.w3.org/2001/XMLSchema#decimal
11
NUMBER
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+46^^http://www.w3.org/2001/XMLSchema#decimal
46
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
instance of
encodes
instance of