NADH dehydrogenase (quinone)
In enzymology, a NADH dehydrogenase (quinone) () is an enzyme that catalyzes the chemical reaction

:NADH + H+ + a quinone formula_1 NAD+ + a quinol

The 3 substrates of this enzyme are NADH, H+, and a quinone (electron acceptor), whereas its two products are NAD+ and a quinol (reduced acceptor).

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, NADH ubiquinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone), and mitochondrial (mt) complex I. This enzyme participates in oxidative phosphorylation. Several compounds are known to inhibit this enzyme, including AMP, and 2,4-dinitrophenol. NADH dehydrogenase is involved in the first step of the electron transport chain of oxidative phosphorylation (OXPHOS). Any change in the electron transport component caused by a mutation might effect the normal electron flow. This might be leading "an increase of bifurcation and generation of superoxidase radicals and increase oxidative stress in various types of cancer cells."

In the electron transport chain NADH is mainly used to create a concentration gradient of hydrogen in order to make ATP. Since After NADH is oxidized a hydrogen is pumped out and NAD+ will be a product.
Q8047
enzymology
Concept
Q8047
enzyme
Concept
Q82264
catalyzes
Concept
Q36534
chemical reaction
Concept
Q12119506
substrates
Concept
Q12499775
NADH
UNK
Q3518755
H+
UNK
Q412382
quinone
Concept
Q1231592
electron acceptor
Concept
Q542929
products
Concept
Q12499775
NAD+
UNK
Q419164
quinol
Concept
Q1231592
reduced acceptor
Concept
Q407479
oxidoreductase
Concept
Q1255355
systematic name
UNK
Q227564
oxidative phosphorylation
Concept
Q427492
inhibit this enzyme
Concept
Q318369
AMP
Concept
Q209226
2,4-dinitrophenol
Concept
Q3575013
NADH dehydrogenase (quinone)
Concept
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2.4^^http://www.w3.org/2001/XMLSchema#decimal
2,4
NUMBER
subclass of
molecular function
subclass of