STIM2
Stromal interaction molecule 2 (STIM2) is a protein that in humans is encoded by the "STIM2" gene.

This gene is a member of the stromal interaction molecule (STIM) family which comprises only two members together with its homologue STIM1, and likely arose from a common ancestral gene. They encode type 1 transmembrane proteins that are located in the sarco/endoplasmic reticulum (SR / ER) into the cell. Alternative translation initiation from an AUG and a non-AUG (UUG) start site results in the production of two different STIM2 isoforms.

Both members of the STIM family were identified in 2005 as free-calcium (Ca2+) sensors which participate in a mechanism of Ca2+ entry into the cell referred to as store-operated Ca2+ entry (SOCE). Many cellular processes and signaling pathways are started by previous release of Ca2+ stored in subcellular organelles, which needs of a continuous refilling. SOCE is considered the mechanism of store refilling and an essential mechanism of Ca2+ signaling in non-electrically excitable cells. While STIM1 triggers SOCE, research on STIM2 function suggests a major role as feedback regulator that stabilizes basal cytosolic and S/ER Ca2+ concentration [Ca2+]. STIM2 detects small decreases in Ca2+ content stored in the S/ER, switches to the activated state and interacts with so called store-operated Ca2+ (SOC) channels located in the plasma membrane, such as Orai or TRPC channels, allowing SOCE. Although the functional role of STIM2 has been elusive for many years, studies performed in 2009-2010 on murine models suggested that STIM2 participates in processes of the development and functioning of many cell types, including smooth muscle myoblasts, cells of the immune system and neurons, and is involved in tumorigenesis, the development of autoimmune diseases and mechanisms of neuronal damage after transient ischemic conditions.
Q8054
protein
Concept
Q7187
gene
Concept
Q15334560
STIM1
MISC
Q424204
transmembrane protein
Concept
None
SR
UNK
Q79927
ER
Concept
Q609809
isoforms
Concept
Q60097
calcium
Concept
Q1283774
store-operated Ca2+ entry (SOCE)
Concept
Q45948
subcellular organelles
Concept
Q1283774
SOCE
Concept
Q1283774
SOCE
Concept
Q220599
cytosol
Concept
Q7392022
store-operated Ca2+ (SOC) channels
UNK
Q29548
plasma membrane
Concept
Q18047835
Orai
MISC
Q7671459
TRPC
Concept
Q1283774
SOCE
Concept
Q428914
myoblasts
Concept
Q1059
immune system
Concept
Q43054
neurons
Concept
Q1637543
tumorigenesis
Concept
Q8084905
autoimmune disease
Concept
Q188151
ischemic
Concept
Q18044275
STIM2
MISC
Q18044275
STIM2
MISC
Q18044275
STIM2
MISC
Q18044275
STIM2
MISC
Q18044275
STIM2
MISC
Q18044275
STIM2
MISC
Q18044275
STIM2
MISC
2005-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2005
DATE
2009-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2009
DATE
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
-2010^^http://www.w3.org/2001/XMLSchema#decimal
-2010
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
instance of
encodes
instance of