MSH2
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the "MSH2" gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair.

Mutations in the MSH2 gene are associated with microsatellite instability and some cancers, especially with hereditary nonpolyposis colorectal cancer (HNPCC).
Q8054
protein
Concept
Q7187
gene
Concept
Q638893
chromosome 2
MISC
Q422445
tumor suppressor gene
Concept
Q5039065
caretaker gene
UNK
Q2984243
DNA mismatch repair
Concept
Q6589727
heterodimer
Concept
Q14911717
MSH6
DIS
Q18029418
MSH3
UNK
Q210538
DNA repair
Concept
Q2714458
transcription-coupled repair
Concept
Q22280388
homologous recombination
Concept
Q3113091
base excision repair
UNK
Q488212
microsatellite instability
UNK
Q783644
hereditary nonpolyposis colorectal cancer
Concept
Q14911688
MSH2
MISC
Q14911688
MSH2
MISC
Q14911688
MSH2
MISC
Q14911688
MSH2
MISC
Q14911688
MSH2
MISC
Q14911688
MSH2
MISC
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
instance of
chromosome
genetic association
encodes
instance of
chromosome
subclass of
genetic association