Eugeroic
Eugeroics (originally "eugrégorique" or "eugregoric"), also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness. They are medically indicated for the treatment of certain sleep disorders including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA). Eugeroics are also often prescribed off-label for the treatment of EDS in idiopathic hypersomnia, a rare and often debilitating sleep disorder which currently has no official treatments approved by the Food and Drug Administration (FDA). In contrast to classical psychostimulants, such as methylphenidate and amphetamine, which are also used in the treatment of these disorders, eugoroics typically do not produce euphoria, and, consequently, have a lower addictive potential. 

Modafinil and armodafinil are each thought to act as selective, weak, atypical dopamine reuptake inhibitors (DRI), whereas adrafinil acts as a prodrug for modafinil. Other eugeroics include solriamfetol, which acts as a norepinephrine–dopamine reuptake inhibitor (NDRI), and pitolisant, which acts as a histamine 3 (H3) receptor antagonist/inverse agonist.
Q8386
drug
Concept
Q246710
wakefulness
Concept
Q1423044
alertness
Concept
Q701216
treatment
Concept
Q177190
sleep disorder
Concept
Q3144201
excessive daytime sleepiness (EDS)
Concept
Q189561
narcolepsy
Concept
Q16606552
obstructive sleep apnea (OSA)
Concept
Q119697
off-label
Concept
Q2730080
idiopathic hypersomnia
Concept
Q204711
Food and Drug Administration (FDA)
Concept
Q211036
psychostimulants
Concept
Q422112
methylphenidate
Concept
Q179452
amphetamine
Concept
Q203994
euphoria
Concept
Q12029
addictive potential
Concept
Q410441
Modafinil
Concept
Q418913
armodafinil
Concept
Q899647
dopamine reuptake inhibitors (DRI)
Concept
Q366482
adrafinil
Concept
Q603741
prodrug
Concept
Q39059979
solriamfetol
Concept
Q961634
norepinephrine–dopamine reuptake inhibitor (NDRI)
UNK
Q426044
pitolisant
Concept
Q5628855
histamine 3 (H3) receptor antagonist
UNK
Q1671731
inverse agonist
UNK
Q30587909
Eugeroic
Concept
Q30587909
Eugeroic
Concept
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