ATG16L1
Autophagy related 16 like 1 is a protein that in humans is encoded by the "ATG16L1" gene. This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to membrane and is released just before or after autophagosome completion. 

Furthermore, ATG16L1 appears to have other autophagy-independent functions, e.g. in the intracellular membrane trafficking regulation and inflammation. Autophagy in general plays crucial role in pathways leading to innate and adaptive immunity activation. That is why many autophagy-related proteins, including ATG16L1, their gene expression and its role in autoimmune diseases are studied in-depth nowadays. 
Q8054
protein
Concept
Q7187
gene
Concept
Q288322
autophagy
Concept
Q18033863
ATG12-
MISC
Q18034312
ATG5
MISC
Q27548992
ATG8
MISC
Q14882441
autophagosome
Concept
Q101991
inflammation
Concept
Q428253
innate
Concept
Q1645075
adaptive immunity
Concept
Q8084905
autoimmune diseases
Concept
Q4654662
ATG16L1
MISC
Q4654662
ATG16L1
MISC
Q4654662
ATG16L1
MISC
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16
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NUMBER
+16^^http://www.w3.org/2001/XMLSchema#decimal
16
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+16^^http://www.w3.org/2001/XMLSchema#decimal
16
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
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instance of
encodes