Lennox–Gastaut syndrome
Lennox–Gastaut syndrome (LGS) is a complex, rare, and severe childhood-onset epilepsy. It is characterized by multiple and concurrent seizure types, cognitive dysfunction, and slow spike waves on electroencephalogram (EEG). Typically, it presents in children aged 3–5 years and can persist into adulthood. It has been associated with several gene mutations, perinatal insults, congenital infections, brain tumors/malformations, and genetic disorders such as tuberous sclerosis and West syndrome. The prognosis for LGS is poor with a 5% mortality in childhood and persistent seizures into adulthood (80%–90%).

LGS was named for neurologists William G. Lennox (Boston, USA) and Henri Gastaut (Marseille, France), who independently described the condition. The international LGS Awareness Day is on November 1.
Q41571
epilepsy
Concept
Q179965
electroencephalogram
Concept
Q42918
gene mutations
Concept
Q1362721
tuberous sclerosis
Concept
Q1041258
West syndrome
Concept
Q83042
neurologists
Concept
Q2578924
William G. Lennox
PER
Q714130
Henri Gastaut
PER
Q1544884
Lennox–Gastaut syndrome
Concept
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3
NUMBER
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5
NUMBER
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90
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health specialty
named after
named after
field of work