Flucytosine
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. It is specifically used, together with amphotericin B, for serious "Candida" infections and cryptococcosis. It may be used by itself or with other antifungals for chromomycosis. Flucytosine is used by mouth and by injection into a vein.
Common side effects include bone marrow suppression, loss of appetite, diarrhea, vomiting, and psychosis. Anaphylaxis and other allergic reactions occasionally occur. It is unclear if use in pregnancy is safe for the baby. Flucytosine is in the fluorinated pyrimidine analogue family of medications. It works by being converted into fluorouracil inside the fungus, which impairs its ability to make protein.
Flucytosine was first made in 1957. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. As of 2016, in the United States the medication cost about US$2,000 per day while in the United Kingdom it is about US$22 per day. It is not available in much of the developing world.
Q578726
antifungal medication
Concept
Q412223
amphotericin B
Concept
Q273510
"Candida" infection
Concept
Q1470140
cryptococcosis
Concept
Q2726043
chromomycosis
Concept
Q640448
injection into a vein
Concept
Q864868
bone marrow suppression
Concept
Q40878
diarrhea
Concept
Q170082
psychosis
Concept
Q168800
Anaphylaxis
Concept
Q42982
allergic reactions
Concept
Q11995
pregnancy
Concept
Q6594591
pyrimidine analogue
UNK
Q238512
fluorouracil
Concept
Q211935
make
Concept
Q8054
protein
Concept
Q37155
World Health Organization's List of Essential Medicines
MEDIA
Q11000047
health system
Concept
Q177323
developing world
Concept
Q238490
Flucytosine
Concept
Q238490
Flucytosine
Concept
Q238490
Flucytosine
Concept
Q238490
Flucytosine
Concept
1957-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
1957
DATE
2016-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2016
DATE
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5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+2.000^^http://www.w3.org/2001/XMLSchema#decimal
2,000
NUMBER
+22^^http://www.w3.org/2001/XMLSchema#decimal
22
NUMBER
subject has role
medical condition treated
medical condition treated
medical condition treated