Frank Benjamin Colton
Frank Benjamin Colton (3 de março de 1923 — 25 de novembro de 2003) foi um químico estadunidense.

Foi o primeiro a sitetisar o Norethynodrel, progestina usada no Enovid, a pílula contraceptiva oral combinada, desenvolvida na G. D. Searle & Company, em 1952.
Frank B. Colton was born in Poland and immigrated to the United States in 1934. He earned his B.S. and M.S. degrees in chemistry from Northwestern University in 1945 and 1946 and his Ph.D. from the University of Chicago in 1950. He was a research fellow at the Mayo Foundation from 1949 to 1951 working with Nobel Laureate Edward C. Kendall to develop an improved synthesis of cortisone.

In 1951 he joined Searle as a senior research chemist. In 1952 Colton synthesized the progestin norethynodrel (an isomer of norethindrone), which combined with the estrogen mestranol as Enovid was approved by the U.S. Food and Drug Administration (FDA) in 1956 for menstrual disorders and in 1960 as the first oral contraceptive. In 1953 he synthesized norethandrolone, which as Nilevar was approved in 1956 as the first oral anabolic steroid. In 1954 Colton and Paul D. Klimstra synthesized the progestin ethynodiol diacetate, which combined with the estrogen mestranol as Ovulen was approved in 1965 as Searle's second oral contraceptive, and combined with the estrogen ethinylestradiol was approved in 1970 as Demulen. Colton retired from Searle in 1986 as research adviser. In 1988 he was inducted into the National Inventors Hall of Fame.
Q2391
3 de março
TIME
Q2169
1923
TIME
Q3020
25 de novembro
TIME
Q1986
2003
TIME
Q2329
químico
Concept
Q30
estadunidense
LOC
None
Norethynodrel
UNK
Q11320751
progestina
Concept
None
Enovid
UNK
Q817281
pílula contraceptiva oral combinada
Concept
None
G. D. Searle & Company
UNK
Q299135
Poland
UNK
Q309350
Northwestern University
LOC
Q131252
University of Chicago
ORG
None
Mayo Foundation
UNK
None
Nobel Laureate
UNK
Q110101
Edward C. Kendall
PER
None
cortisone
UNK
None
isomer
UNK
None
norethindrone
UNK
None
estrogen
UNK
Q904308
mestranol
Concept
None
U.S. Food and Drug Administration
UNK
None
norethandrolone
UNK
None
anabolic steroid
UNK
None
ethynodiol diacetate
UNK
None
ethinylestradiol
UNK
None
Demulen
UNK
Q1366018
National Inventors Hall of Fame
LOC
Q5485107
Frank Benjamin Colton
PER
1923-03-03T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
3 de março de 1923
DATE
2003-11-25T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
25 de novembro de 2003
DATE
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1952
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1934
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1946
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1954
NUMBER
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1965
NUMBER
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1970
NUMBER
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1986
NUMBER
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1988
NUMBER
country of citizenship
date of birth
date of death
award received