Sicarius ornatus
Sicarius ornatus is a species of venomous spider found in South America (Brazil). It has a highly toxic venom like the other South American sicariid, "Loxosceles laeta" and the African "Hexophthalma hahni", but there are few human bites recorded. Its venom has active sphingomyelinase D, and can lead to a severe pathology.

The venom of Sicarius ornatus contains active sphingomyelinase D, the main toxin responsible for local and systemic effects, the venom of S. ornatus is endowed with all toxic properties in vitro and ex vivo, and like Loxosceles, it is capable and hydrolyzes sphingomyelin , induce cell death of keratinocytes and complement-dependent hemolysis, harmful events that have been associated with the presence of active sphingomyelinase D and pathologies in vivo, these studies indicate that the venom of S. ornatus can potentially lead to a pathology similar to that of Loxosceles.
Q2549274
venomous spider
Concept
Q18
South America
LOC
Q155
Brazil
LOC
Q137895
Loxosceles laeta
Concept
Q55586198
Hexophthalma hahni
Concept
Q10761561
sphingomyelinase D
UNK
Q1950866
Loxosceles
Concept
Q1473931
keratinocytes
Concept
Q471706
hemolysis
Concept
Q2736501
Sicarius ornatus
Concept
Q2736501
Sicarius ornatus
Concept
endemic to
part of