Long COVID
Long COVID, also known as post COVID syndrome, post-acute sequelae of COVID-19 (PASC), chronic COVID syndrome (CCS) and long-haul COVID, is a condition characterized by long-term sequelae—appearing or persisting after the typical convalescence period—of coronavirus disease 2019 (COVID-19). Long COVID can affect nearly every organ system with sequelae including respiratory system disorders, nervous system and neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain, and anemia. A wide range of symptoms are commonly discussed, including fatigue, headaches, shortness of breath, anosmia (loss of smell), parosmia (distorted smell), muscle weakness, low fever and cognitive dysfunction.

The exact nature of symptoms and number of people who experience long-term symptoms is unknown and varies according to the population being studied, the definition used, and the time period used in the study. A preliminary survey by the UK Office of National Statistics estimated that approximately 10% of people who tested positive for SARS-CoV-2 experienced one or more symptoms for longer than 12 weeks.

While studies into various aspects of long COVID are under way, , the definition of the illness is still unclear and it is too early to draw conclusions on the mechanism. Health systems in some countries or jurisdictions have been mobilized to deal with this group of patients by creating specialized clinics and providing advice. Nonetheless, the illness is not well-characterized, has no understood mechanism nor fixed diagnostic criteria, and therefore is considered an idiopathic disease, and a diagnosis of exclusion.

Some believe that it is possible that anyone infected with SARS-CoV-2 may suffer from long COVID after the infection is considered to have ended. For example, a widely-publicized study in 2020 suggested that SARS-CoV-2 infection led to cardiac inflammation in a survey of student athletes, however, other researchers have subsequently cast doubt on this claim, suggesting that the findings may be due to diagnostic bias or confusion with other conditions. More recently, researchers have reported that initial disease severity does not correlate positively to post-COVID-19 symptom severity, but rather, frequently affects healthier patients that did not obtain medical care.

While long COVID is observed after COVID-19 infection, it has not been reported after COVID-19 vaccination, with over 100,000 participants included in vaccine trials .
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Long COVID
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Q100732653
Long COVID
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