Tropomyosin receptor kinase A
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the "NTRK1" gene.

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Q8054
protein
Concept
Q7187
gene
Concept
Q24719927
neurotrophic tyrosine kinase receptor (NTKR) family
Concept
Q420457
neurotrophin
Concept
Q3630494
autophosphorylation
Concept
Q14197552
MAPK pathway
UNK
Q501694
congenital insensitivity to pain with anhidrosis
Concept
Q12078
cancer
Concept
Q14897694
Tropomyosin receptor kinase A
Concept
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1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
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NUMBER
instance of
encodes