PDZ domain
The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. These domains play a key role in the formation and function of signal transduction complexes. PDZ domains also play a highly significant role in the anchoring of cell surface receptors (such as Cftr and FZD7) to the actin cytoskeleton via mediators like NHERF and ezrin.

"PDZ" is an initialism combining the first letters of the first three proteins discovered to share the domain — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1). PDZ domains have previously been referred to as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains.

In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation. This means that the beta sheet in the PDZ domain is extended by the addition of a further beta strand from the tail of the binding partner protein. The C-terminal carboxylate group is bound by a nest (protein structural motif) in the PDZ domain.
Q898273
structural domain
Concept
Q8066
amino-acids
Concept
Q828130
signaling
Concept
Q8054
proteins
Concept
Q10876
bacteria
Concept
Q45422
yeast
Concept
Q756
plants
Concept
Q808
virus
Concept
Q729
animal
Concept
Q2476074
cell surface receptors
Concept
Q420470
Cftr
Concept
Q18032822
FZD7
MISC
Q185269
actin
Concept
Q154626
cytoskeleton
Concept
Q18034036
NHERF
UNK
Q18032329
ezrin
Concept
Q101244
initialism
Concept
Q21102524
post synaptic density protein (PSD95)
MISC
Q17914009
Drosophila disc large tumor suppressor (Dlg1)
MISC
Q18031999
zonula occludens-1 protein (zo-1)
UNK
Q620730
glycine
Concept
Q483745
leucine
Concept
Q170545
phenylalanine
Concept
Q310425
C-terminus
LOC
Q283449
beta sheet
Concept
Q6997750
nest (protein structural motif)
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
Q24721050
PDZ domain
Concept
+80^^http://www.w3.org/2001/XMLSchema#decimal
80
NUMBER
-90^^http://www.w3.org/2001/XMLSchema#decimal
-90
NUMBER
+7^^http://www.w3.org/2001/XMLSchema#decimal
7
NUMBER
+95^^http://www.w3.org/2001/XMLSchema#decimal
95
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
-1^^http://www.w3.org/2001/XMLSchema#decimal
-1
NUMBER
-1^^http://www.w3.org/2001/XMLSchema#decimal
-1
NUMBER
instance of
part of
part of