Immunometabolism
Immunometabolism is a branch of biology that studies the interplay between metabolism and immunology in all organisms. In particular, immunometabolism is the study of the molecular and biochemical underpinninngs for i) the metabolic regulation of immune function, and ii) the regulation of metabolism by molecules and cells of the immune system. Further categorization includes i) systemic immunometabolism and ii) cellular immunometabolism. 

Immunometabolism first appears in the academic literature in 2011, where it is defined as "an emerging field of investigation at the interface between the historically distinct disciplines of immunology and metabolism." A later article defines immunometabolism as describing "the changes that occur in intracellular metabolic pathways in immune cells during activation". Broadly, immunometabolic research records the physiological functioning of the immune system in the context of different metabolic conditions in health and disease. These studies can cover molecular and cellular aspects of immune system function "in vitro", "in situ", and "in vivo," under different metabolic conditions. For example, highly proliferative cells such as cancer cells and activating T cells undergo metabolic reprogramming, increasing glucose uptake to shift towards aerobic glycolysis during normoxia. While aerobic glycolysis is an inefficient pathway for ATP production in quiescent cells, this so-called “Warburg effect” supports the bioenergetic and biosynthetic needs of rapidly proliferating cells.

Immunometabolism is an area of growing drug discovery research investment in numerous areas of medicine, such as for example, in lessening the impact of age-related metabolic dysfunction and obesity on incidence of type 2 diabetes/ cardiovascular disease, cancer, as well as infectious diseases.
Q420
biology
Concept
Q1057
metabolism
Concept
Q101929
immunology
Concept
Q7239
organism
Concept
Q521
physiological
Concept
Q221681
in vitro
Concept
None
in situ
UNK
Q141124
in vivo
Concept
Q11190
medicine
Concept
Q12174
obesity
Concept
Q3025883
type 2 diabetes
Concept
Q389735
cardiovascular disease
Concept
Q12078
cancer
Concept
Q104843720
Immunometabolism
UNK
Q104843720
Immunometabolism
UNK
Q104843720
Immunometabolism
UNK
2011-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2011
DATE
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
studies
subclass of