Cytokeratin 5/6 antibodies
Cytokeratin 5/6 antibodies are antibodies that target both cytokeratin 5 and cytokeratin 6. These are used in immunohistochemistry, often called CK 5/6 staining, including the following applications:
*Identifying basal cells or myoepithelial cells in the breast and prostate.
*For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions (having a mosaic-like pattern) from ductal carcinoma in situ, which is usually negative. Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary carcinoma (Cyclin D1 > 37.00%, CK 5/6 negative).
*In the lung, distinguishing epithelioid mesothelioma (CK5/6 positive in 83%) from lung adenocarcinoma (CK5/6 negative in 85%).
Q79460
antibodies
Concept
Q14907905
cytokeratin 5
MISC
Q14864155
cytokeratin 6
DIS
Q899285
immunohistochemistry
Concept
Q2254965
basal cells
Concept
Q1476681
myoepithelial cell
UNK
Q835051
hyperplasia
Concept
Q337585
ductal carcinoma in situ
Concept
Q15311861
Cyclin D1
MISC
Q1077603
mesothelioma
Concept
Q843799
lung adenocarcinoma
Concept
Q96375801
Cytokeratin 5/6 antibodies
Concept
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+4.20^^http://www.w3.org/2001/XMLSchema#decimal
4.20
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+1^^http://www.w3.org/2001/XMLSchema#decimal
1
NUMBER
+37.00^^http://www.w3.org/2001/XMLSchema#decimal
37.00
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+83^^http://www.w3.org/2001/XMLSchema#decimal
83
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+6^^http://www.w3.org/2001/XMLSchema#decimal
6
NUMBER
+85^^http://www.w3.org/2001/XMLSchema#decimal
85
NUMBER
subclass of