Mixed-phenotype acute leukemia
Mixed-phenotype acute leukemia (MPAL) is a group of blood cancers (leukemia) which have combined features of myeloid and lymphoid cancers. It is a rare disease, constituting about 2–5% of all leukemia cases. It mostly involve myeloid with either of T lymphocyte or B lymphocyte progenitors, but in rare cases all the three cell lineages. Knowledge on the cause, clinical features and cellular mechanism is poor, making the treatment and management (prognosis) difficult.

The name "mixed-phenotype acute leukemia" was adopted by the World Health Organization in 2008 to include leukemias of ambiguous lineage, acute undifferentiated leukemias and natural killer lymphoblastic leukemias. According to WHO criteria, myeloid lineage is characterised by the presence of myeloperoxidase, while B and T lymphoid lineages are indicated by the expression of CD19 and cytoplasmic CD3.
Q29496
leukemia
Concept
Q11688946
myeloid
Concept
Q6708277
lymphoid cancers
Concept
Q193529
T lymphocyte
Concept
Q188930
B lymphocyte
Concept
Q7817
World Health Organization
Concept
Q420012
myeloperoxidase
Concept
Q798033
CD19
MISC
Q419458
CD3
MISC
Q54553070
Mixed-phenotype acute leukemia
Concept
2008-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2008
DATE
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2
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5
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+19^^http://www.w3.org/2001/XMLSchema#decimal
19
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
subclass of
subclass of
subclass of