5-Formylcytosine
5-Formylcytosine (5fC) is a pyrimidine nitrogen base derived from cytosine. In the context of nucleic acid chemistry and biology, it is regarded as an epigenetic marker. Discovered in 2011 in mammalian embryonic stem cells by Thomas Carell's research group the modified nucleoside was more recently confirmed to be relevant both as an intermediate in the active demethylation pathway and as a standalone epigenetic marker. In mammals, 5fC is formed by oxidation of 5-Hydroxymethylcytosine (5hmC) a reaction mediated by TET enzymes. Its molecular formula is C5H5N3O2.
Q207722
pyrimidine
Concept
Q422960
nitrogen base
Concept
Q178425
cytosine
Concept
Q109816
Thomas Carell
PER
Q238535
5-Hydroxymethylcytosine
Concept
Q97357913
TET enzymes
UNK
Q27146337
5-Formylcytosine
UNK
2011-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
2011
DATE
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+5^^http://www.w3.org/2001/XMLSchema#decimal
5
NUMBER
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
subclass of