Varenicline
Varenicline (trade name Chantix and Champix) is a prescription medication used to treat tobacco use disorder. It both reduces craving for and decreases the pleasurable effects of nicotine from cigarettes and other tobacco products.

It is a high-affinity partial agonist for the α4β2 nicotinic acetylcholine receptor subtype (nACh) that leads to the release of the neurotransmitter dopamine in the nucleus accumbens reward center of the brain when activated, and therefore, has the capacity to reduce the feelings of craving and withdrawal caused by smoking cessation. In this respect it is similar to cytisine and different from the nicotinic antagonist bupropion and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. It is estimated that varenicline successfully helps one of every 11 people who smoke remain abstinent from tobacco at six months.
Q18553444
tobacco use disorder
Concept
Q28086552
nicotine
Concept
Q1578
cigarette
Concept
Q1566
tobacco
Concept
Q770260
partial agonist
Concept
Q412256
nicotinic acetylcholine receptor
Concept
Q162657
neurotransmitter
Concept
Q170304
dopamine
Concept
Q1476178
nucleus accumbens
UNK
Q2462253
smoking cessation
Concept
Q417343
cytisine
Concept
Q2080426
nicotinic antagonist
Concept
Q834280
bupropion
Concept
Q1189783
nicotine replacement therapies
Concept
Q2431064
nicotine patch
UNK
Q4348342
nicotine gum
Concept
Q614132
successfully helps one of every 11 people
UNK
Q411330
Varenicline
Concept
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4
NUMBER
+2^^http://www.w3.org/2001/XMLSchema#decimal
2
NUMBER
+11^^http://www.w3.org/2001/XMLSchema#decimal
11
NUMBER
instance of