Ethandrostate
Ethandrostate, also known as ethinylandrostenediol 3β-cyclohexanepropionate, is a synthetic steroidal estrogen and ester of ethinylandrostenediol (17α-ethynyl-5-androstenediol) which was developed and studied in people with certain cancers like breast cancer and prostate cancer in the 1950s but was never marketed. Although far less potent by weight than estradiol or estrone, ethandrostate produces estrogenic effects in the vagina, uterus, and mammary glands as well as antigonadotropic and secondary antiandrogenic effects like testicular and prostate atrophy in both animals and humans. Ethandrostate was assessed in humans as an aqueous suspension by intramuscular injection at doses of 100 to 200 mg/day or 100 mg three times per week and by mouth at a dose of 25 mg four times per day. It shows much greater antigonadotropic potency relative to general estrogenic potency in animals when compared with other estrogens. However, this doesn't seem to be the case in humans. In addition to its estrogenic activity, ethandrostate has very weak androgenic activity that manifests only at doses much higher than its estrogenic activity.
Q174211
synthetic
Concept
Q177911
steroid
Concept
Q48841284
estrogen
Concept
Q101487
ester
Concept
Q82937795
ethinylandrostenediol
UNK
Q12078
cancer
Concept
Q128581
breast cancer
Concept
Q181257
prostate cancer
Concept
Q2066956
potent
Concept
Q12415847
estradiol
Concept
Q55611080
estrone
Concept
Q48841284
estrogen
Concept
Q5880
vagina
Concept
Q9612
uterus
Concept
Q189961
mammary gland
Concept
Q4774757
antigonadotropic
UNK
Q574820
antiandrogen
Concept
Q1622678
testicular
Concept
Q9625
prostate
Concept
Q194520
atrophy
Concept
Q26100
aqueous suspension
Concept
Q432083
intramuscular injection
Concept
Q285166
by mouth
Concept
Q62614
androgen
Concept
Q97193729
Ethandrostate
UNK
Q97193729
Ethandrostate
UNK
1950-01-01T00:00:00Z^^http://www.w3.org/2001/XMLSchema#dateTime
1950
DATE
+3^^http://www.w3.org/2001/XMLSchema#decimal
3
NUMBER
+17^^http://www.w3.org/2001/XMLSchema#decimal
17
NUMBER
-5^^http://www.w3.org/2001/XMLSchema#decimal
-5
NUMBER
+25^^http://www.w3.org/2001/XMLSchema#decimal
25
NUMBER
subclass of