Infection-induced anorexia
In association with fever production, decreased food consumption is a common sign of infection. Infection-induced anorexia (IIA) performs a vital function during an infection. That is, anorexia is an active defence mechanism that is beneficial for host defence. IIA is a behaviour systematically organised for pathogen elimination. During infection-induced anorexia, autophagic flux is upregulated systemically. A decrease in serum amino acids during an infection promotes autophagy not only in immune cells, but also in nonimmune cells. Augmented autophagic responses may play a critical role in clearing pathogens (xenophagy), in the presentation of epitopes in nonprovisional antigen presenting cells and the removal of damaged proteins and organelles, and recycling these damaged proteins, organelles and pathogens as source of nutrition.
Q38933
fever
Concept
Q166231
infection
Concept
Q254327
anorexia
Concept
Q221673
host
Concept
Q170065
pathogen
Concept
Q288322
autophagic
Concept
Q110084
serum
Concept
Q8066
amino acids
Concept
Q166231
infection
Concept
Q288322
autophagy
Concept
Q42395
immune cells
Concept
Q7868
cells
Concept
Q288322
autophagic
Concept
Q170065
pathogens
Concept
Q8043643
xenophagy
UNK
Q85850789
Infection-induced anorexia
Concept
subclass of