london europe drug regulator issue 31.8 million-pound 42 million tender temporary workers warn could face major budget hit struggle fallout brexit uproot london base london canary wharf since 1995 staff around 890 european medicine agency ema act one-stop-shop approve monitor safety drug across europe agency applaud drug company patient group streamline europe drug approval process ability operate smoothly challenge enforce move new location march 2019. ema anticipate staff losses challenge agency operability could also result major deficit budget organization say statement friday meet management board operations delay stop could dramatic drop fee income company pay products review could exacerbate cost replace staff many expect quit rather leave london shortfall would need make european union budget ema say executive director guido rasi tell reuters interview early week crucial work approve new drug run safety check would put risk politicians pick unsuitable new location prepare fallout move impact britain leave european union already create extra work ema force cut back non-critical activities although ema regularly employ temporary workers scale new staff tender unusually large tender document call bi-lingual multi-lingual staff administrative scientific regulatory legal expertise work ema 's current london office tinyurl.com/yc29jj7b agency must base eu country political leaders set decide vote nov. 20 new location among 19 cities vie host organization staff survey last week find 19 94 percent employees likely leave move depend location choose pick amsterdam barcelona vienna milan copenhagen new headquarter would best option retain staff survey find eu drug agency seek staff warn brexit budget hit