u.s. democrat senator claire mccaskill thursday ask kaleo pharmaceuticals justify 550 percent surge price device treat painkiller overdose become second senator question evzio 4,500 price tag evzio contain overdose-reversing drug naloxone use emergencies people without medical train privately hold kaleo raise price twin-pack 4,500 690 2014 accord kaiser health news report bit.ly/2kfzxaq concern evzio price come time pharmaceutical company face intense scrutiny price-gouging lawmakers struggle epidemic opioid abuse center disease control prevention estimate least 91 americans succumb every day opioid overdose experts partly blame unrestricted painkiller prescriptions `` time congress work expand access naloxone products assist state local communities equip first responders life-saving drug startle price hike concern `` mccaskill say letter kaleo chief executive spencer williamson bit.ly/2kybump letter sign 30 u.s. senators ask kaleo information evzio price structure company choose adjust price receive letter senators communication ensure question address williamson tell reuters e-mail statement democrat senator amy klobuchar send kaleo letter early month voice similar concern williamson say americans commercial insurance prescription could get evzio approve 2014 out-of-pocket cost 360 pay cash add people without insurance household income 100,000 could get evzio out-of-pocket cost kaleo product auvi-q emergency allergy auto-injector rival mylan nv epipen come intense criticism last year high price kaleo say last month would offer auvi-q cost many consumers set list price use benchmark cost insurance company whop 4,500 senators question kaleo 4,500 tag opioid overdose treatment