washington republican u.s. senators john mccain marco rubio party nominations tuesday seek re-election arizona florida november high profile politicians defeat insurgent challengers mccain 2008 fail republican presidential candidate face spirit challenge arizona democrat ann kirkpatrick serve u.s. house representatives since 2011 want move senate mccain say year race could tough political career span three decades advance general election 80-year-old mccain handily beat ex-state senator kelli ward 47 conservative tea party activist follower republican presidential candidate donald trump like mccain rubio also gird potentially tough challenge nov. 8. also florida u.s. representative debbie wasserman schultz overcome challenger embarrassment strip last month job head democratic national committee get shoot seventh house term nov. general elections beat law professor tim canova outspoken wall street critic align u.s. senator bernie sanders non-traditional campaign trump sanders exceed expectations fail democratic white house bid spur speculation insurgent politicians could make impact year happen either closely watch nominate race florida arizona rubio abandon presidential campaign march clear initial hurdle battle second six-year term u.s. senate defeat novice politician carlos beruff millionaire homebuilder embrace trump u.s. representative patrick murphy democrat party senate nomination tuesday expect give rubio tough fight especially democratic presidential candidate hillary clinton lead trump florida speculation rubio might still harbor presidential ambition media report week refuse commit serve six years senate term re-elected trump endorse mccain rubio re-election bid even though rocky relations mccain rubio fare could big say whether republicans defy expectations maintain majority control senate november election balance senate outcome presidential election hang florida rubio predict fundraise appeal late tuesday trump offend mccain many republicans last year suggest maverick senator anything war hero capture vietnam war airplane shoot bomb mission march trump end rubio presidential run trounce florida primary cap race new york businessman taunt first-term senator little marco rubio fire back insult trump everything hair color size hand misspell word tweet re-election efforts mccain rubio offer support trump party white house nominee steer clear attack might antagonize trump core supporters tiptoe around trump mainly concern provocative comment illegal immigration muslims u.s. support nato could alienate moderate independent voters state version story correct mccain fail presidential bid second paragraph 2008 2012 mccain rubio win republican nod u.s. senate race