text: i have heard that strattera and wellbutrin do not work well together. why is this? does it cause physical harm?  or something simpler like reducing the effects of each other?  as deep as you understand it, how does this happen between the chemistry of the two and the biology of the human mind? the answer lies in the mechanism of action of the two medications.    atomoxetine (strattera) is a norepinephrine re-uptake inhibitor inhibitor that acts almost exclusively on the noradrenergic pathway.  bupropion (wellbutrin) inhibits the re-uptake of norepinephrine and dopamine neurotransmission without any significant direct effects on serotonin neurotransmission.  so as you can see the medications act on similiar mechanism and therefore taking them both would be like overdosing on either.  wellbutrin can also promote seizure which is dose related too.  in sum, taking them together could be dangerous.