text: explain the differences bet tween a gene mutation and a chromosome mutation?   a chromosome mutation is a change that involves a part of, or an entire chromosome: examples: non-homologous translocations, additions or deletions caused by chromosomal breakage and reattachment, inversions, nondisjunction, polyploidy, to name a few .  a gene mutation involves a change in dna, like mis- pairing of the n-bases .this is considered a biochemical change.  there are specific genetic disorders in humans associated with either chromosome or gene mutations.