text: minocycline dosage? i've had a little acne popping up and my dr. gave me minocycline prescription... take 1 - 100mg pill a day.  i've been looking other places and lots of people say they are taking 2 - 100 mg pills a day.  i want this med to help as fast and good as possible so should i ask my dr. if i can take 2 pills a day or is 1 fine? 100 mg  twice daily is the normal dose for moderate to severe acne.  if your acne is not too severe, than 100mg's should be perfect for you.  don't up the dose without your doc's permission, there may be a reason why he has you on this dose.