text: i get little blisters on my thumb & index finger that feel like a little pin prick.  what is that from???   your blisters is awarning that you have pushed too hard on something or things, or you are doing rough work without wearing gloves. these are called friction blisters. it occurs when you rub constantly on something. if your fingers and hands are sensitive, it will occur even faster. like winter has just passed, so if you wore rough.. garden like gloves the blister could have occured from that too. so if any rubbing on your skin causes the skin and tissue under your skin to serparate. the roughness created causes it to feel like a pin prick.