text: what cause an elevated liver enzymes? alkaline phosphatase and ast and alt this is a symptom of a disease or condition, but you will need follow up in order to know which one is causing your elevated liver enzymes.  common causes of elevated liver enzymes include:  medications, such as certain nonsteroidal anti-inflammatory drugs, cholesterol-lowering medications, antibiotics and anti-seizure medications  drinking too much alcohol  obesity  diabetes  elevated triglycerides  infection, such as viral hepatitis and mononucleosis  autoimmune disorders of the liver and bile ducts, such as autoimmune hepatitis and primary sclerosing cholangitis and primary biliary cirrhosis  metabolic liver disease, such as hemochromatosis and wilson's disease  excessive use of vitamin supplements and certain herbal supplements  tumors of the liver or bile ducts  treatment of elevated liver enzyme depends on the underlying cause.   http://www.mayoclinic.com/health/elevated-liver-enzymes/hq01011