text: how long for glyburide to relieve symptoms? i have type ii diabetes(recently diagnosed) and i am taking glyburide 2.5 mg once a day. i have been taking it for about a week now and would like to know for those who have taken it, how long does it take to relieve the symptoms, ie, dry mouth and constant urination? when i asked my doctor she said it would take a while, but i want to know from people who have taken it. any help appreciated. thanks one week of taking it should relieve the symptoms...u should check your blood sugar...and see if it is within normal level,  if not..re-evaluate ur medication, u might need to combine it with another medication..or u might even need insulin temporarily