text: many mutations in rna result in changes in proteins.? what mutation in a gene would result in no change in the protein for the gene. there is an answer, but i can't think of it. if the codon is changed so that it still codes for the same amino acid, it will not change the protein.  for example, if the original codon is ucu (serine), and it is mutated to ucc, it will still code for serine.