text: how long should you keep a splinter in your skin? is it okay for a splinter to be in your arm or your leg for a day or two? will it cause an infection in a day or two? i just want to live. splinter will work their way out, your body rejects it.  when it does come out you will notice a little pus, not to worry, you'll live.  put some antibiotic ointment on it and you're as good as new.