text: what would you say ,works the  best out of anti-depression ..mood stabilizers  meds? and why? my sister has  a severe depression and her doctor has put her on  about 5 different meds,seems nothing is working,,she either has side effects,,,,or they just dont work,and yes she  is taking them right and really trying to get well,shes  had a really bad year,alot of problems went on in her life,but we just cant get the right meds ,that work for her.thanks i can sum it up in a nut shell-what ever works for you is the best anti-depressant the best mood stablizer-everyone has different chemistry so you really can't ask which is the best because were all different!! that's all you need know!