text: what is the relationship between ubiquitin protease system and huntington disease? genetics the main histopathological feature of huntington's disease (hd) is the presence of protein aggregates that are gathered into inclusion bodies. so far the mechanisms that lead to inclusion formation as well as their role in the pathogenesis of hd are not totally understood. however, it is well established that inclusion bodies contain components of the ubiquitin-proteasome system. accordingly, it has been postulated that impairment of this machinery can be one of the causes of this disorder. in this review, the authors summarize the state of current knowledge about this hypothesis.