text: what can cause liver enzimes to be elevated? liver enzimes are normal 40!!!! my doctor says!! but i am curious to know what about if it is 400. why can that cause a liver emzyme to be that elevated? elevated levels might involve hepatocellular disease, active cirrhosis, metastatic liver tumor, infection or toxic hepatitis, severe burns, pancreatitis, myocardial infarction (heart attack), trauma, severe burns, acute hemolytic anemia, crushing injuries, gangrene or shock.  http://ww2.khou.com/global/story.asp?s=1230520  common causes of elevated liver enzymes include:  medications, such as certain nonsteroidal anti-inflammatory drugs, cholesterol-lowering medications, antibiotics and anti-seizure medications  drinking too much alcohol  obesity  diabetes  elevated triglycerides  infection, such as viral hepatitis and mononucleosis  autoimmune disorders of the liver and bile ducts, such as autoimmune hepatitis and primary sclerosing cholangitis and primary biliary cirrhosis  metabolic liver disease, such as hemochromatosis and wilson's disease  excessive use of vitamin supplements and certain herbal supplements  tumors of the liver or bile ducts  http://www.mayoclinic.com/health/elevated-liver-enzymes/hq01011