text: what do you do when you get depressed? i take prozac and usually am okay but every now? and then i get in moods that are very depressing. i wont leave the house, dont wanna talk, can only dweel on negative things.... any suggestions? i have been taking prozac for a long time. do not ever skip days without taking. the level of medicine in your body can get out of whack and you can have side effects that are not good. thoughts of suicide,bad nightmares, bouts of extreme depression. also the prozac might need to be adjusted. you really need to talk with your doctor.