text: what are the apparent symptoms of sick liver or spieen ?   well, there can be many symptoms in which the doctor will try and treat seperately.....but...a small list of ailments associated with liver disease are:  depression and/or "brain fog" lethargy achey joints/bones any type of skin rash (whether or not they itch) hair loss confusion/short term memory upper right quandrant pain (a very mild pain to severe) gallbladder disease diabetes lung disease weight loss or gain thyroid disease your spleen can have intense sharp pains panic attacks (due to change in how the brains system relates to either toxins and/or viral infections like hepatitis c)  not all of those with a chronic disease of the liver have jaundice, infact, a person with hepatitis c-unless an acute infection or end stage liver disease will not have jaundice (yellowing of the skin caused by billibrium buildup)   there are many other diseases that are caused by liver disease.  if you have one diseased organ it can cause other organs to become diseased as well-they are call bi-directional diseases.  if you have had a liver panel and your test comes back all within normal ranges, you can still be sick!  alt and ast levels are a lot of times not increased-this is more common in those with hepatitis c. alt and ast levels are not a reliable source, only getting an actual hepatitis c antibody test is.  good luck