text: what is a safe dose of extra strength tylenol? my husband has to wait till thurs. to get a tooth pulled that is causing him great pain. i got him some extra strength tylenol 500mg....what is the most he can take? the pain is severe and he has to work in a hot factory and put up with the pain! help me help him! two at a time every 4 hours, but i found that excedrin does much better for tooth aches.