text: does penicillin vk make your urine smell like medication? i'm taking 500 mg. 4 times a day for strep throat.  i've taken a total of 5 doses and my urine has a strong medicinal smell.  what does that mean? yes it does. penicillins are eliminately primarily through kidney excretion into the urine.  your urine will smell just like the pills... a wonderful bitter moldy smell.  it shouldn't mean anything at all.