text: has anyone had problems with diffrent anti-depressants? i have tried many but they all make me really sick,this last one i tried, zoloft made me feel like i was on speed. i havent slept for two days. the docs all know this but they keep trying diffrent meds and i am geting a little tired of being really sick. .scared to try anything else yes i have taken them all from elavil to celexa to zoloft and so on. they never did help me well they made me worse but now i am on xanax and i am telling you i feel so much better. this is a wonder drug for me. but everyone is different. good luck and hope you feel better..