text: what is the best prescibed acne medicine for nodular acne?   i took accutane, a prescribed medication for serious acne. it has a high success rate, however, doctors are wary of prescribing it because it does have some side effects. also, you have to take a monthly blood test so they can see if you are pregnant. otherwise, if you are you must stop the meds immediately because it causes severe birth defects. all in all, a wonderful medication that changed my life. however, i guess there are some downfalls where ever you look.