text: a man suffering from hepatitis can have physical relation with his wife? my uncle is suffering from hepatitis.now if he sleeps with his wife ..does it effect his wife ..does it harmful for her. hepatitis a and b are both vaccine-preventable. in my opinion, everyone who is eligible should get vaccinated for these hep viruses.tell your aunt to consider a vaccination.  hep a is transmitted fecal-orally through contaminated food or water.  hep b is bloodborne or sexually transmitted. but you can prevent it with a series of three shots.  hep c is bloodborne, but can carry a tiny chance of sexual transmission. there is no vaccine for it, though. but it should still be safe for your uncle to have relations with his wife if he has hep c.