text: i was taking 5 mg of abilify the dr but me up to 10 and i feel more depressed and manic to day then yesterday? has anyone ever been like this yeah, it can happen a lot. lamictal was a bitch to titrate up on - every dosage increase caused a few days of insane mood cycling.  abilify is an odd one: it's an antipsychotic approved for the treatment of bipolar mania. it hits serotonin, dopamine and histamine receptors, which makes it activating rather than sedating like most atypical antipsychotics. all very odd, but it should settle down in a week or two, but if it doesn't then go see your doc again.