text: should we retire? after 6 long years, we have accrued about $500k in a pharmaceutical investment that has a 95% chance of passing fda.  it has received priority review status and will be the only drug in a very large market.  tomorrow it moves from the amex to the nasdaq.  should we keep our investment and take the slight risk with the chance for huge reward, or should we take the money off the table and have a modest retirement?  we have about $400k in equity in our current house and owe about $200k on our retirement property.  we also have about $225k in other investments.  we are 40 and 42 and both have good jobs and no kids.  neither of us wants to work any more.  well, not for the time being anyway.  we both have the wander lust and basically need the stock to double to have everything we'll ever want for the rest of our lives.  if it passes, it will do at least that.  but, we could walk away today and live modestly.  what would you do? if i were in youre shoes i'd take a slight risk for the huge reward.if it falls through youre still set up pretty good with equities and other investments,plus youre still very young and if need be could work a few more years .it doesnt appear to me if it doesnt get approved youre out on welfare.successful people seem to be risk takers .i'm not saying you should do it i'm saying if it were me i would !