text: if you had latent tb, and you're done with medication, is it okay to donate blood? i'm done with the treatment, and i want to donate blood. and im used to all that needle stuff. tuberculosis if you have active tuberculosis or are being treated for active tuberculosis you should not donate. acceptable if you have a positive skin test, but no active tuberculosis, or if you are receiving antibiotics for a positive tb skin test only. if you are being treated for a tuberculosis infection, wait until treatment is successfully completed before donating.