text: ganglion cyst? i have had this lump on my knee for quite a while and i decided to have it checked out by a doctor. the doctor diagnosed it as a ganglion cyst. what is it and how can i cure it? my husband gets those every 6 months or so on his wrist.  his doctor told him that the cyst is a build-up of fluid in an area between joints that did not fuse together correctly.  the doctor told my husband to do one of two options to get rid of it.  he could either let the doctor hit the cyst to make it pop and release the fluid...or he could simply wait it out and eventually it would do it on it's own.  he chose option 2. it finally burst, and his wrist went back to normal.  the cyst comes back sometimes because of a type of inflammation that occurs in the joint from working out.