text: is it  to be concerned when someone diagnosed cirrhosis of the liver, and get cramp in liver & nose bleeds? my dad was diagnosed with cirrhosis of the liver and only 10% of it works. this morning he woke up with some sort of cramp and pressure on the liver and his nose started bleeding. is something to be concerned about? yes, you should be concerned.  in those with liver disease or those who take blood thinning medications (such as heart patients) biochemical events cannot lead to the formation of the final clot. in this cascade, prothrombin is a precursor to thrombin- basically those with advanced liver disease do not produce enough chemicals to produce clotting.  a person can bleed to death.  i wish i could tell you something positive. seek the advice of a doctor asap.  good luck.