text: what are the long term effects of vicodin dependency.? i have been taking approximately three vicodin - hp (10mg/660mg) tablets per day for 7 years since i had an aortic dissection - surgery included aortic valve replacement and aortic graft. i suffer from pain and take the "as prescribed" dosage of one table every six hours, but only three times per day.  i was wondering if any medical professionals could weigh in on the subject of long term effects of either the hydrocodone or acetametaphine part of the drug on the physical body.  i take many other medications to keep my bp low and my blood thin.  i am a 44 year old retired male, 6 foot 7 inches, 215 pounds. too much vicodin can effect the liver.make sure you only take as directed..no more.