text: what happens if actifed is eaten with vodka? or any other hard drink if you eat it then what will happen actifed was used to decongest mucus during a cold. it is a banned substance today.  the side effects of actifed are intense drowsiness and dehydration.  vodka or any other alcohol also causes dehydration and drowsiness.  this is a portent combination for a major health problem including muscular cramps and brain damage. avoid actifed. there are better drugs available today.