text: whats the most adictive drug?   cocaine is the most addictive (and most dangerous) drug.  it is an alkaloid found in leaves of the south american shrub erythroxylon coca. it is a powerfully reinforcing psychostimulant. the drug induces a sense of exhilaration in the user primarily by blocking the reuptake of the neurotransmitter dopamine in the midbrain.  as a rule of thumb, it is extremely unwise to experiment with cocaine.  scientists have found that the pleasure receptors in the brain experience one hundred times more stimulation when using cocaine than when having an orgasm!  now that's a lot of pleasure!!!  imagine how addicted you would be if you ever experienced anything like it!  not to mention that it ruins your life, because nothing will ever bring you as much joy as it used to, now that you've experienced the new high.  but yeah, the answer to your question is crack cocaine.