text: who hit the first home run in the very first major league baseball game?   to expand on the previous answer: the first major league game was april 22, 1876 between the boston red caps and the philadelphia athletics.  no home run was hit in that game.  the first home run was hit by ross barnes of the chicago white stockings on may 2, 1876  against the cincinnati red stockings.  (charley jones of the red stockings hit a homer later in the game for the 2nd home run in history.)