text: is zoloft better than prozac? what has been your experience for depression/anxiety?   i take lithium,effexor, and xanax for depression and bi-polar(i like the cold weather sometimes). if you can get away with no medication, that is your best bet. every couple of months my meds need "tweaked" and the side effects are not worth it. i don't feel as sharp as i use to be. my wife says this is the only way she can tolerate me. if i try to go cold turkey, i get really out of whack and miss like a whole week of work. it is not worth it. if you are dead set on getting on medication, find a doctor you trust and take what he tells you to take.  btw, i can't believe you got this many responses so quickly!