text: what are the side affects from taking orthotrycyline low? i've been having really bad mood swings and it is affecting my relationship w/ my fiance, could it be due to my birth control pills? yes. this is a side effect.  it's related to the hormones...so as time goes by your body will adjust.  dont self treat you depression/mood swings with any supplements (like st johns wort) they effect the reliablilty of the pill.  talk to you doc about this.