text: can you take zoloft with adderall? can you take zoloft with adderall if you are taking zoloft for panic attacks? i would definitely not recommend it since adderall is a stimulant and can cause a panic attack in a panic-prone person.  there are better meds to combine with zoloft if you have panic problems along with attention problems.  i personally feel that adderall is too powerful a stimulant to be used in a panic-prone person but i am not a pharmacist (only a psychology graduate student who took psychopharmacology and loved it).  please ask your doctor or better a pharmacist before taking that combination.  i doubt it would be fatal but it could cause a panic attack and would not likely be helpful in any way.