@inproceedings{zhang-etal-2024-knowledge,
    title = "Knowledge-aware Attention Network for Medication Effectiveness Prediction",
    author = "Zhang, Yingying  and
      Wu, Xian  and
      Zhang, Yu  and
      Zheng, Yefeng",
    editor = "Calzolari, Nicoletta  and
      Kan, Min-Yen  and
      Hoste, Veronique  and
      Lenci, Alessandro  and
      Sakti, Sakriani  and
      Xue, Nianwen",
    booktitle = "Proceedings of the 2024 Joint International Conference on Computational Linguistics, Language Resources and Evaluation (LREC-COLING 2024)",
    month = may,
    year = "2024",
    address = "Torino, Italia",
    publisher = "ELRA and ICCL",
    url = "https://aclanthology.org/2024.lrec-main.856",
    pages = "9799--9809",
    abstract = "The first 24 hours{'} medication plan is critical to patients with serious or life-threatening illnesses and injuries. An appropriate medication can result in a lower mortality, a shorter length stay and a higher APACHE score. However, in clinical practice, the medication plan is often error-prone, especially when a decision must be made quickly for life-threatening situations in Intensive Care Unit (ICU). Therefore, predicting the effectiveness of the first 24 hours{'} medication plan is of great importance in assisting doctors to make proper decisions. Existing effectiveness prediction works usually focus on one specific medicine, one specific disease, or one specific lab test, making it hard to extend to general medicines and diseases in hospital/ICU scenarios. In this paper, we propose to predict medication effectiveness of the first 24 hours in hospital/ICU based on patients{'} information. Specifically, we use a knowledge enhanced module to incorporate external knowledge about medications and a medical feature learning module to determine the interaction between diagnosis and medications. To handle the data imbalance problem, we further optimize the proposed model with a contrastive loss. Extensive experimental results on a public dataset show that our model can significantly outperform state-of-the-art methods.",
}

The first 24 hours{'} medication plan is critical to patients with serious or life-threatening illnesses and injuries. An appropriate medication can result in a lower mortality, a shorter length stay and a higher APACHE score. However, in clinical practice, the medication plan is often error-prone, especially when a decision must be made quickly for life-threatening situations in Intensive Care Unit (ICU). Therefore, predicting the effectiveness of the first 24 hours{'} medication plan is of great importance in assisting doctors to make proper decisions. Existing effectiveness prediction works usually focus on one specific medicine, one specific disease, or one specific lab test, making it hard to extend to general medicines and diseases in hospital/ICU scenarios. In this paper, we propose to predict medication effectiveness of the first 24 hours in hospital/ICU based on patients{'} information. Specifically, we use a knowledge enhanced module to incorporate external knowledge about medications and a medical feature learning module to determine the interaction between diagnosis and medications. To handle the data imbalance problem, we further optimize the proposed model with a contrastive loss. Extensive experimental results on a public dataset show that our model can significantly outperform state-of-the-art methods.
Zhang, Yingying Wu, Xian Zhang, Yu Zheng, Yefeng
Knowledge-aware Attention Network for Medication Effectiveness Prediction