When was Dolly the Sheep born?
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Dolly was born on 5 July 1996 and had three mothers: one provided the egg, another the DNA, and a third carried the cloned embryo to term. She was created using the technique of somatic cell nuclear transfer, where the cell nucleus from an adult cell is transferred into an unfertilized oocyte (developing egg cell) that has had its cell nucleus removed. The hybrid cell is then stimulated to divide by an electric shock, and when it develops into a blastocyst it is implanted in a surrogate mother. Dolly was the first clone produced from a cell taken from an adult mammal. The production of Dolly showed that genes in the nucleus of such a mature differentiated somatic cell are still capable of reverting to an embryonic totipotent state, creating a cell that can then go on to develop into any part of an animal. Dolly's existence was announced to the public on 22 February 1997. It gained much attention in the media. A commercial with Scottish scientists playing with sheep was aired on TV, and a special report in "Time" magazine featured Dolly the sheep. "Science" featured Dolly as the breakthrough of the year. Even though Dolly was not the first animal cloned, she received media attention because she was the first cloned from an adult cell.
Dolly (sheep)
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Dolly, a Finn-Dorset ewe, was the first mammal to have been successfully cloned from an adult somatic cell. Dolly was formed by taking a cell from the udder of her 6-year old biological mother. Dolly's embryo was created by taking the cell and inserting it into a sheep ovum. It took 434 attempts before an embryo was successful. The embryo was then placed inside a female sheep that went through a normal pregnancy. She was cloned at the Roslin Institute in Scotland by British scientists Sir Ian Wilmut and Keith Campbell and lived there from her birth in 1996 until her death in 2003 when she was six. She was born on 5 July 1996 but not announced to the world until 22 February 1997. Her stuffed remains were placed at Edinburgh's Royal Museum, part of the National Museums of Scotland.
Cloning
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Dolly was cloned by Keith Campbell, Ian Wilmut and colleagues at the Roslin Institute, part of the University of Edinburgh, Scotland, and the biotechnology company PPL Therapeutics, based near Edinburgh. The funding for Dolly's cloning was provided by PPL Therapeutics and the Ministry of Agriculture. She was born on 5 July 1996 and died from a progressive lung disease five months before her seventh birthday (the disease was not considered related to her being a clone). She has been called "the world's most famous sheep" by sources including BBC News and "Scientific American".
Dolly (sheep)
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In 1996 Dolly the sheep was born, the first mammal to be cloned from an adult cell. The process by which Dolly the sheep was cloned utilized a process known as nuclear transfer applied by lead scientist Ian Wilmut. Although other scientists were not immediately able to replicate the experiment, Wilmut argued that the experiment was indeed repeatable, given a timeframe of over a year.
History of animal testing
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Dolly (5 July 1996 – 14 February 2003) was a female domestic sheep, and the first mammal cloned from an adult somatic cell, using the process of nuclear transfer.
Dolly (sheep)
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On 14 February 2003, Dolly was euthanised because she had a progressive lung disease and severe arthritis. A Finn Dorset such as Dolly has a life expectancy of around 11 to 12 years, but Dolly lived 6.5 years. A post-mortem examination showed she had a form of lung cancer called ovine pulmonary adenocarcinoma, also known as Jaagsiekte, which is a fairly common disease of sheep and is caused by the retrovirus JSRV. Roslin scientists stated that they did not think there was a connection with Dolly being a clone, and that other sheep in the same flock had died of the same disease. Such lung diseases are a particular danger for sheep kept indoors, and Dolly had to sleep inside for security reasons.
Dolly (sheep)
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Dolly lived her entire life at the Roslin Institute in Midlothian. There she was bred with a Welsh Mountain ram and produced six lambs in total. Her first lamb, named Bonnie, was born in April 1998. The next year Dolly produced twin lambs Sally and Rosie, and she gave birth to triplets Lucy, Darcy and Cotton in 2000. In late 2001, at the age of four, Dolly developed arthritis and began to walk stiffly. This was treated with anti-inflammatory drugs.
Dolly (sheep)
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Dolly the sheep was born on 7 February 1997 as the first animal cloned from adult cells. The institutional arrangements behind this scientific feat demonstrate the increasing “embeddedness” of political, scientific, and economic processes at work in the production of knowledge. Dolly was a product of three intimately linked institutions: The Roslin Research Institute (government funded), PPL Therapeutics (private firm), and Edinburgh University. Formally, these are all separate entities, but in reality they are intertwined and should be considered hybrid institutions. PPL, whose involvement in funding the Dolly project was driven by potential commercial applications, was originally a ‘spin-off’ from the Roslin Institute. The Roslin institute was initially formed to take advantage of the strong biomedical department at Edinburgh University, and over 50 PhD students from the University were involved in the Dolly project. Such hybrid arrangements are increasingly important, “the hybridity that these institutes represent” subverts views of a linear relationship between science and policy and demonstrates the required “intellectual pluralism and flexibility” in public science systems . Again, the neoliberal context is evident here, with state-funded entities having to engage with the private sector and demonstrate economic worthiness to maintain legitimacy.
Hybrid institutions and governance
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Dolly Sinatra (born Natalina Maria Vittoria Garaventa; December 26, 1896 – January 6, 1977) was the mother of American singer Frank Sinatra. She was born in Lumarzo (Province of Genoa), in northern Italy; she immigrated to the United States when she was two months old. When she was a child, her pretty face earned her the nickname "Dolly".
Dolly Sinatra
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● Professor Dan Burk finds that "the "Roslin" opinion is hardly a model of coherent judicial reasoning, either on its own terms or with regard to the Supreme Court's subject matter jurisprudence to that point." He insists that Dolly the cloned sheep was not something found in nature, because "genetically identical mammals are not what one finds in the wild." Rather, "mammals such as sheep propagate via sexual recombination which typically renders them "not" genetically identical." Furthermore, Dolly was born as an old sheep:
In Re Roslin Institute (Edinburgh)
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Dr Alan William Greenwood CBE FRSE (29 June 1897 – 4 May 1981) was a Scottish zoologist and geneticist, who helped pave the way to creating Dolly the Sheep. He served as Director of the Poultry Research Centre from 1947 until 1962.
Alan William Greenwood