How large is chromosome 6?
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Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the Major Histocompatibility Complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.
Chromosome 6
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Chromosome 5 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 5 spans about 181 million base pairs (the building blocks of DNA) and represents almost 6% of the total DNA in cells. Chromosome 5 is the 5th largest human chromosome, yet has one of the lowest gene densities. This is partially explained by numerous gene-poor regions that display a remarkable degree of non-coding and syntenic conservation with non-mammalian vertebrates, suggesting they are functionally constrained.
Chromosome 5
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In humans, MAPK 6 gene  is located on the distal arm of chromosome 15 (15q21.2). It is 47.01kb long and is transcribed in the centromere to telomere orientation. It consist of 6 exons with the translation initiation codon which is located in exon2.
MAPK6
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The following are some of the genes located on p-arm (short arm) of human chromosome 6:
The following are some of the genes located on q-arm (long arm) of human chromosome 6:
The following diseases are some of those related to genes on chromosome 6:
Chromosome 6
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The FAM129C gene is 30,538 base pairs long and is mapped to 19p.13.112 on chromosome 19 (NC_000019.10) from 17523301 to 17553839 in humans. Chromosome 19 has highest gene density of all human chromosomes and large clustered gene families corresponding to high G + C content, CpG islands, and high-density repetitive DNA suggest evolutionary significance for genes located here. Based on location and expression of FAM129C gene, this would suggest it has a role in immune system function.
FAM129C
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ㅜ is one of the Korean hangul. The Unicode for ㅜ is U+315C.
ㅜ
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Genetic analysis techniques have led to the identification of chromosomal abnormalities associated with metastatic tumor progression in uveal melanoma. Loss of heterozygosity, loss of entire alleles from chromosomes, partial chromosomal addition and deletion and single nucleotide polymorphisms (SNP) have been associated with uveal melanoma metastatic lesions. In particular, chromosomes 1, 3, 6 and 8 have been extensively studied for their association with shorter survival time and development of metastatic disease. While genetic aberrations in chromosomes 1, 6 and 8 have not independently been able to predict disease progression, cytogenetic profiling of chromosome 3 has uncovered an important genetic region highly associated with metastatic onset in uveal melanoma patients. Chromosome 3 abnormalities have been analyzed using multiple techniques, including fluorescence in situ hybridization (FISH), chromosomal in situ hybridization (CISH), array comparative genomic hybridization (aCGH), SNP, multiplex ligation-dependent probe amplification (MLPA), and microsatellite analysis. Despite a wealth of data that has identified the association of chromosome 3 mutation with UM metastasis, the clinical application of this data has yet to be realized. Reasons for the uncertainty of chromosome 3 clinical use include 1) high false-positive rates (ranging from 5-22%), 2) high false-negative rates (ranging from 4-50%), 3) high technical failure rates (up to 50%) due to the large tissue requirement for current analysis techniques, and 4) the adverse effects of cellular heterogeneity on chromosome 3 cytogenetic analysis. Furthermore, unlike the DecisionDx-UM test, there are no published, peer-reviewed studies that demonstrate clinical validation in an independent set of patients.
DecisionDx-UM
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This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). Other names in common use include trimethyllysine alpha-ketoglutarate dioxygenase, TML-alpha-ketoglutarate dioxygenase, TML hydroxylase, 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase, and (3-hydroxylating). This enzyme participates in lysine degradation and L-carnitine biosynthesis and requires the presence of iron and ascorbate.
Trimethyllysine dioxygenase
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ㅞ is one of the Korean hangul. The Unicode for ㅞ is U+315E.
ㅞ
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ㅝ is one of the Korean hangul. The Unicode for ㅝ is U+315D.
ㅝ