title: Suburb

text: Economic growth in the United States encouraged the suburbanization of American cities that required massive investments for the new infrastructure and homes. Consumer patterns were also shifting at this time, as purchasing power was becoming stronger and more accessible to a wider range of families. Suburban houses also brought about needs for products that were not needed in urban neighborhoods, such as lawnmowers and automobiles. During this time commercial shopping malls were being developed near suburbs to satisfy consumers' needs and their car–dependent lifestyle.


title: Suburb

text: Zoning laws also contributed to the location of residential areas outside of the city center by creating wide areas or "zones" where only residential buildings were permitted. These suburban residences are built on larger lots of land than in the central city. For example, the lot size for a residence in Chicago is usually deep, while the width can vary from wide for a row house to wide for a large stand–alone house. In the suburbs, where stand–alone houses are the rule, lots may be wide by deep, as in the Chicago suburb of Naperville. Manufacturing and commercial buildings were segregated in other areas of the city.


title: Suburb

text: Alongside suburbanization, many companies began locating their offices and other facilities in the outer areas of the cities, which resulted in the increased density of older suburbs and the growth of lower density suburbs even further from city centers. An alternative strategy is the deliberate design of "new towns" and the protection of green belts around cities. Some social reformers attempted to combine the best of both concepts in the garden city movement.


title: Suburb

text: In the U.S., 1950 was the first year that more people lived in suburbs than elsewhere. In the U.S, the development of the skyscraper and the sharp inflation of downtown real estate prices also led to downtowns being more fully dedicated to businesses, thus pushing residents outside the city center.


title: Suburb

text: In many parts of the developed world, suburbs can be economically distressed areas, inhabited by higher proportions of recent immigrants, with higher delinquency rates and social problems. Sometimes the notion of suburb may even refer to people in real misery, who are kept at the limit of the city borders for economic, social, and sometimes ethnic reasons. An example in the developed world would be the "banlieues" of France, or the concrete suburbs of Sweden, even if the suburbs of these countries also include middle-class and upper-class neighborhoods that often consist of single-family houses. Some of the suburbs in most of the developed world are comparable to several inner cities of the U.S.


title: Suburb

text: Following the growth of the middle class due to African industrialization, the development of middle class suburbs has boomed since the beginning of the 1990s, particularly in cities such as Cairo, Nairobi, Johannesburg, and Lagos.


title: Suburb

text: In an illustrative case of South Africa, RDP housing has been built. In much of Soweto, many houses are American in appearance, but are smaller, and often consist of a kitchen and living room, two or three bedrooms, and a bathroom. However, there are more affluent neighborhoods, more comparable to American suburbs, particularly east of the FNB ("Soccer City") Stadium) and south of the city in areas like Eikenhof, where the “Eye of Africa” planned community exists. This master-planned community is nearly indistinguishable from the most amenity-rich resort-style American suburbs in Florida, Arizona, and California, complete with a golf course, resort pool, equestrian facility, 24-hour manned gates, gym, and BMX track, as well as several tennis, basketball, and volleyball courts.


title: Suburb

text: In Cape Town, there is a distinct European style originating from European influence during the mid-1600s when the Dutch settled the Cape. Houses like these are called Cape Dutch Houses and can be found in the affluent suburbs of Constantia and Bishopscourt.


title: Suburb

text: The Australian usage came about as outer areas were quickly surrounded in fast-growing cities, but retained the appellation "suburb"; the term was eventually applied to the original core as well. In Australia, Sydney's urban sprawl has occurred predominantly in the Western Suburbs. The locality of Olympic Park was designated an official suburb in 2009.


title: Suburb

text: Bangladesh has multiple suburbs, Uttara & Ashulia to name a few. However, most suburbs in Dhaka are different than the ones in Europe & Americas. Most suburbs in Bangladesh are filled with high rise buildings, paddy fields, and farms, and are designed more like rural villages.


title: Suburb

text: Canada is an urbanized nation where over 80% of the population live in urban areas (loosely defined), and roughly two-thirds live in one of Canada's 33 census metropolitan areas (CMAs) with a population of over 100,000. However, of this metropolitan population, in 2001 nearly half lived in low-density neighborhoods, with only one in five living in a typical "urban" neighborhood. The percentage living in low-density neighborhoods varied from a high of nearly two-thirds of Calgary CMA residents (67%), to a low of about one-third of Montréal CMA residents (34%).


title: Suburb

text: Often, Canadian suburbs are less automobile-centric and public transit use is encouraged but can be notably unused. Throughout Canada, there are comprehensive plans in place to curb sprawl.


title: Suburb

text: Population and income growth in Canadian suburbs had tended to outpace growth in core urban or rural areas, but in many areas this trend has now reversed. The suburban population increased 87% between 1981 and 2001, well ahead of urban growth. The majority of recent population growth in Canada's three largest metropolitan areas (Greater Toronto, Greater Montréal, and Greater Vancouver) has occurred in non-core municipalities. This trend is also beginning to take effect in Vancouver, and to a lesser extent, Montréal. In certain cities, particularly Edmonton and Calgary, suburban growth takes place within the city boundaries as opposed to in bedroom communities. This is due to annexation and large geographic footprint within the city borders.


title: Suburb

text: Calgary is unusual among Canadian cities because it has developed as a unicity – it has annexed most of its surrounding towns and large amounts of undeveloped land around the city. As a result, most of the communities that Calgarians refer to as "suburbs" are actually inside the city limits. In the 2016 census, the City of Calgary had a population of 1,239,220, whereas the Calgary Metropolitan Area had a population of 1,392,609, indicating the vast majority of people in the Calgary CMA lived within the city limits. The perceived low population density of Calgary largely results from its many internal suburbs and the large amount of undeveloped land within the city. The city actually has a policy of densifying its new developments.


title: Suburb

text: In China, the term suburb is new, although suburbs are already being constructed rapidly. Chinese suburbs mostly consist of rows upon rows of apartment blocks and condos that end abruptly into the countryside. Also new town developments are extremely common. Single family suburban homes tend to be similar to their Western equivalents; although primarily outside Beijing and Shanghai, also mimic Spanish and Italian architecture.


title: Suburb

text: In Hong Kong, however, suburbs are mostly government-planned new towns containing numerous public housing estates. However, other new towns also contain private housing estates and low density developments for the upper classes.


title: Suburb

text: In the illustrative case of Rome, Italy, in the 1920s and 1930s, suburbs were intentionally created "ex novo" to give lower classes a destination, in consideration of the actual and foreseen massive arrival of poor people from other areas of the country. Many critics have seen in this development pattern (which was circularly distributed in every direction) also a quick solution to a problem of public order (keeping the unwelcome poorest classes together with the criminals, in this way better controlled, comfortably remote from the elegant "official" town). On the other hand, the expected huge expansion of the town soon effectively covered the distance from the central town, and now those suburbs are completely engulfed by the main territory of the town. Other newer suburbs (called exurbs) were created at a further distance from them.


title: Suburb

text: In Japan, the construction of suburbs has boomed since the end of World War II and many cities are experiencing the urban sprawl effect.


title: Suburb

text: In Mexico, suburbs are generally similar to their United States counterparts. Houses are made in many different architectural styles which may be of European, American and International architecture and which vary in size. Suburbs can be found in Guadalajara, Mexico City, Monterrey, and most major cities. Lomas de Chapultepec is an example of an affluent suburb, although it is located inside the city and by no means is today a suburb in the strict sense of the word. In other countries, the situation is similar to that of Mexico, with many suburbs being built, most notably in Peru and Chile, which have experienced a boom in the construction of suburbs since the late 1970s and early 80s. As the growth of middle-class and upper-class suburbs increased, low-class squatter areas have increased, most notably "lost cities" in Mexico, campamentos in Chile, barriadas in Peru, villa miserias in Argentina, asentamientos in Guatemala and favelas of Brazil.


title: Suburb

text: Brazilian affluent suburbs are generally denser, more vertical and mixed in use inner suburbs. They concentrate infrastructure, investment and attention from the municipal seat and the best offer of mass transit. True sprawling towards neighboring municipalities is typically empoverished – ("the periphery", in the sense of it dealing with spatial marginalization) –, with a very noticeable example being the rail suburbs of Rio de Janeiro – the North Zone, the Baixada Fluminense, the part of the West Zone associated with SuperVia's Ramal de Santa Cruz. These, in comparison with the inner suburbs, often prove to be remote, violent food deserts with inadequate sewer structure coverage, saturated mass transit, more precarious running water, electricity and communication services, and lack of urban planning and landscaping, while also not necessarily qualifying as actual or slums. They often are former agricultural land or wild areas settled through squatting; suburbs grew and expanded due to the mass rural exodus during the years of the military dictatorship. This is particularly true of São Paulo, Rio de Janeiro and Brasília, which grew with migration from more distant and impoverished parts of the country and deal with overpopulation as a result.


title: Suburb

text: In Malaysia, suburbs are common, especially in areas surrounding the Klang Valley, which is the largest conurbation in the country. These suburbs also serve as major housing areas and commuter towns. Terraced houses, Semi-detached houses and shophouses are common concepts in suburbs. In certain areas such as Klang, Subang Jaya and Petaling Jaya, suburbs form the core of these places. The latter one has been turned into a satellite city of Kuala Lumpur. Suburbs are also evident in other major conurbations in the country including Penang (e.g. Pulau Tikus), Ipoh (e.g. Bercham), Johor Bahru (e.g. Tebrau), Kota Kinabalu (e.g. Likas), Kuching (e.g. Stampin), Melaka City (e.g. Batu Berendam) and Alor Setar (e.g. Anak Bukit).


title: Suburb

text: In Russia, until recently, the term suburb refers to high-rise residential apartments which usually consist of two bedrooms, one bathroom, a kitchen and a living room. However, since the beginning of the 21st century in Russia there has been a "cottage boom", as a result of which a huge number of cottage villages appeared in almost every city of the country (including Moscow), no different from the suburbs in western countries.


title: Suburb

text: In the United Kingdom suburbs are located between the exurbs and downtowns of a metropolitan area. The growth in the use of trains, and later automobiles and highways, increased the ease with which workers could have a job in the city while commuting in from the suburbs. In the United Kingdom, as mentioned above, railways stimulated the first mass exodus to the suburbs. The Metropolitan Railway, for example, was active in building and promoting its own housing estates in the north-west of London, consisting mostly of detached houses on large plots, which it then marketed as "Metro-land". In the UK, the government is seeking to impose minimum densities on newly approved housing schemes in parts of South East England. The goal is to "build sustainable communities" rather than housing estates. However, commercial concerns tend to delay the opening of services until a large number of residents have occupied the new neighborhood.


title: Suburb

text: In the 20th century, many suburban areas, especially those not within the political boundaries of the city containing the central business area, began to see independence from the central city as an asset. In some cases, suburbanites saw self-government as a means to keep out people who could not afford the added suburban property maintenance costs not needed in city living. Federal subsidies for suburban development accelerated this process as did the practice of redlining by banks and other lending institutions. In some cities such as Miami, San Francisco, and Washington, D.C., the main city is much smaller than the surrounding suburban areas, leaving the city proper with a small portion of the metro area's population and land area.


title: Suburb

text: Mesa, Arizona, and Virginia Beach, Virginia, the two most populous suburbs in the United States, are actually more populous than many core cities, including Miami, Minneapolis, New Orleans, Cleveland, Tampa, St. Louis, Pittsburgh, Cincinnati, and others. Virginia Beach is now the largest city in all of Virginia, having long since exceeded the population of its neighboring primary city, Norfolk. While Virginia Beach has slowly been taking on the characteristics of an urban city, it will not likely achieve the population density and urban characteristics of Norfolk. It is generally assumed that the population of Chesapeake, another Hampton Roads city, will also exceed that of Norfolk in 2018 if its current growth rate continues at its same pace.


title: Suburb

text: Cleveland, Ohio, is typical of many American central cities; its municipal borders have changed little since 1922, even though the Cleveland urbanized area has grown many times over. Several layers of suburban municipalities now surround cities like Boston, Cleveland, Chicago, Detroit, Los Angeles, Dallas, Denver, Houston, New York City, San Francisco, Sacramento, Atlanta, Miami, Baltimore, Milwaukee, Pittsburgh, Philadelphia, Phoenix, Roanoke, St. Louis, Salt Lake City, Las Vegas, Minneapolis, and Washington, D.C..


title: Suburb

text: By 2010, suburbs increasingly gained people in racial minority groups, as many members of minority groups gained better access to education and sought more favorable living conditions compared to inner city areas.


title: Suburb

text: Conversely, many white Americans also moved back to city centers. Nearly all major city downtowns (such as Downtown Miami, Downtown Detroit, Downtown Philadelphia, Downtown Roanoke, or Downtown Los Angeles) are experiencing a renewal, with large population growth, residential apartment construction, and increased social, cultural, and infrastructural investments, as have suburban neighborhoods close to city centers. Better public transit, proximity to work and cultural attractions, and frustration with suburban life and gridlock have attracted young Americans to the city centers.


title: Suburb

text: Suburbs typically have longer travel times to work than traditional neighborhoods. Only the traffic "within" the short streets themselves is less. This is due to three factors: almost-mandatory automobile ownership due to poor suburban bus systems, longer travel distances and the hierarchy system, which is less efficient at distributing traffic than the traditional grid of streets.


title: Suburb

text: In the suburban system, most trips from one component to another component requires that cars enter a collector road, no matter how short or long the distance is. This is compounded by the hierarchy of streets, where entire neighborhoods and subdivisions are dependent on one or two collector roads. Because all traffic is forced onto these roads, they are often heavy with traffic all day. If a traffic crash occurs on a collector road, or if road construction inhibits the flow, then the entire road system may be rendered useless until the blockage is cleared. The traditional "grown" grid, in turn, allows for a larger number of choices and alternate routes.


title: Suburb

text: Suburban systems of the sprawl type are also quite inefficient for cyclists or pedestrians, as the direct route is usually not available for them either. This encourages car trips even for distances as low as several hundreds of yards or meters (which may have become up to several miles or kilometers due to the road network). Improved sprawl systems, though retaining the car detours, possess cycle paths and footpaths connecting across the arms of the sprawl system, allowing a more direct route while still keeping the cars out of the residential and side streets.


title: Suburb

text: More commonly, central cities seek ways to tax nonresidents working downtown – known as commuter taxes – as property tax bases dwindle. Taken together, these two groups of taxpayers represent a largely untapped source of potential revenue that cities may begin to target more aggressively, particularly if they're struggling. According to struggling cities, this will help bring in a substantial revenue for the city which is a great way to tax the people who make the most use of the highways and repairs.


title: Suburb

text: Suburbs and suburban living have been the subject for a wide variety of films, books, television shows and songs.


title: Suburb

text: French songs like "La Zone" by Fréhel (1933), "Aux quatre coins de la banlieue" by Damia (1936), "Ma banlieue" by Reda Caire (1937), or "Banlieue" by Robert Lamoureux (1953), evoke the suburbs of Paris explicitly since the 1930s. Those singers give a sunny festive, almost bucolic, image of the suburbs, yet still few urbanized. During the fifties and the sixties, French singer-songwriter Léo Ferré evokes in his songs popular and proletarian suburbs of Paris, to oppose them to the city, considered by comparison as a bourgeois and conservative place.


title: Suburb

text: French cinema was although soon interested in urban changes in the suburbs, with such movies as "Mon oncle" by Jacques Tati (1958), "L'Amour existe" by Maurice Pialat (1961) or "Two or Three Things I Know About Her" by Jean-Luc Godard (1967).


title: Suburb

text: In his one-act opera "Trouble in Tahiti" (1952), Leonard Bernstein skewers American suburbia, which produces misery instead of happiness.


title: Suburb

text: The American photojournalist Bill Owens documented the culture of suburbia in the 1970s, most notably in his book "Suburbia". The 1962 song "Little Boxes" by Malvina Reynolds lampoons the development of suburbia and its perceived bourgeois and conformist values, while the 1982 song "Subdivisions" by the Canadian band Rush also discusses suburbia, as does Rockin' the Suburbs by Ben Folds. The 2010 album "The Suburbs" by the Canadian-based alternative band Arcade Fire dealt with aspects of growing up in suburbia, suggesting aimlessness, apathy and endless rushing are ingrained into the suburban culture and mentality. "Suburb The Musical," was written by Robert S. Cohen and David Javerbaum. Over the Hedge is a syndicated comic strip written and drawn by Michael Fry and T. Lewis. It tells the story of a raccoon, turtle, a squirrel, and their friends who come to terms with their woodlands being taken over by suburbia, trying to survive the increasing flow of humanity and technology while becoming enticed by it at the same time. A film adaptation of Over the Hedge was produced in 2006.


title: Suburb

text: British television series such as "The Good Life", "Butterflies" and "The Fall and Rise of Reginald Perrin" have depicted suburbia as well-manicured but relentlessly boring, and its residents as either overly conforming or prone to going stir crazy. In contrast, U.S. shows such as "Knots Landing", "Desperate Housewives" and "Weeds" portray the suburbs as concealing darker secrets behind a façade of manicured lawns, friendly people, and beautifully kept houses. Films such as "The 'Burbs" and "Disturbia" have brought this theme to the cinema.


title: Jonah

text: Jonah or Jonas, son of Amittai, is a prophet in the Hebrew Bible and the Quran, from Gath-hepher of the northern kingdom of Israel in about the 8th century BCE. Jonah is the central figure of the Book of Jonah, which details his reluctance in delivering God's judgement on the city of Nineveh. Subsequently he returns to the divine mission after he is swallowed by a large sea creature and then released.


title: Jonah

text: In Judaism, the story of Jonah represents the teaching of "teshuva", which is the ability to repent and be forgiven by God. In the New Testament, Jesus calls himself "greater than Jonah" and promises the Pharisees "the sign of Jonah", which is his resurrection. Early Christian interpreters viewed Jonah as a type for Jesus. Jonah is regarded as a prophet in Islam, and the biblical narrative of Jonah is repeated in the Quran. Mainstream Bible scholars generally regard the Book of Jonah as fictional, and often at least partially satirical. The character of Jonah son of Amittai may have been based on the historical prophet of the same name who prophesied during the reign of Amaziah of Judah, as mentioned in 2 Kings.


title: Jonah

text: Although the creature that swallowed Jonah is often depicted in art and culture as a whale, the Hebrew text uses the phrase "dag gadol", which means "big fish". In the seventeenth and early eighteenth centuries, the species of the fish that swallowed Jonah was the subject of speculation by naturalists, who interpreted the story as an account of a historical incident. Some modern scholars of folklore, on the other hand, note similarities between Jonah and other legendary religious and mythical figures, specifically Gilgamesh and the Greek hero Jason.


title: Jonah

text: Jonah is the central character in the Book of Jonah, in which God commands him to go to the city of Nineveh to prophesy against it "for their great wickedness is come up before me," but Jonah instead attempts to flee from "the presence of the Lord" by going to Jaffa (sometimes transliterated as "Joppa" or "Joppe"). He sets sail for Tarshish. A huge storm arises and the sailors, realizing that it is no ordinary storm, cast lots and discover that Jonah is to blame. Jonah admits this and says that if he is thrown overboard, the storm will cease. The sailors refuse to do this and continue rowing, but all their efforts fail, and they eventually throw Jonah overboard. As a result, the storm calms and the sailors offer sacrifices to God.


title: Jonah

text: After being cast from the ship, Jonah is swallowed by a large fish, within the belly of which he remains for three days and three nights. While in the great fish, Jonah prays to God in his affliction and commits to giving thanks and to paying what he has vowed. God commands the fish to vomit Jonah out.


title: Jonah

text: God again commands Jonah to travel to Nineveh and prophesy to its inhabitants. This time he travels there and enters the city, crying, "In forty days Nineveh shall be overthrown." After Jonah has walked across Nineveh, the people begin to believe his word and proclaim a fast. The king of Nineveh puts on sackcloth and sits in ashes, making a proclamation which decrees fasting, the wearing of sackcloth, prayer, and repentance. God sees their repentant hearts and spares the city at that time. The entire city is humbled and broken, with the people (and even the animals) wearing sackcloth and ashes.


title: Jonah

text: Displeased by this, Jonah refers to his earlier flight to Tarshish while asserting that, since God is merciful, it was inevitable that God would turn from the threatened calamities. He leaves the city and makes a shelter, waiting to see whether or not the city will be destroyed. God causes a plant (in Hebrew a "kikayon") to grow over Jonah's shelter to give him some shade from the sun. Later, God causes a worm to bite the plant's root and it withers. Jonah, exposed to the full force of the sun, becomes faint and pleads for God to kill him.


title: Jonah

text: The Book of Jonah (Yonah יונה) is one of the twelve minor prophets included in the Tanakh. According to one tradition, Jonah was the boy brought back to life by Elijah the prophet in 1 Kings. Another tradition holds that he was the son of the woman of Shunem brought back to life by Elisha in 2 Kings and that he is called the "son of Amittai" ("Truth") due to his mother's recognition of Elisha's identity as a prophet in 2 Kings. The Book of Jonah is read every year, in its original Hebrew and in its entirety, on Yom Kippur – the Day of Atonement – as the Haftarah at the afternoon mincha prayer. According to Rabbi Eliezer, the fish that swallowed Jonah was created in the primordial era and the inside of its mouth was like a synagogue; the fish's eyes were like windows and a pearl inside its mouth provided further illumination.


title: Jonah

text: According to the Midrash, while Jonah was inside the fish, it told him that its life was nearly over because soon the Leviathan would eat them both. Jonah promised the fish that he would save them. Following Jonah's directions, the fish swam up alongside the Leviathan and Jonah threatened to leash the Leviathan by its tongue and let the other fish eat it. The Leviathan heard Jonah's threats, saw that he was circumcised, and realized that he was protected by the Lord, so it fled in terror, leaving Jonah and the fish alive. The medieval Jewish scholar and rabbi Abraham ibn Ezra (1092–1167) argued against any literal interpretation of the Book of Jonah, stating that the "experiences of all the prophets except Moses were visions, not actualities." The later scholar Isaac Abarbanel (1437–1509), however, argued that Jonah could have easily survived in the belly of the fish for three days, because "after all, fetuses live nine months without access to fresh air."


title: Jonah

text: Teshuva – the ability to repent and be forgiven by God – is a prominent idea in Jewish thought. This concept is developed in the Book of Jonah: Jonah, the son of truth (the name of his father "Amitai" in Hebrew means truth), refuses to ask the people of Nineveh to repent. He seeks the truth only, and not forgiveness. When forced to go, his call is heard loud and clear. The people of Nineveh repent ecstatically, "fasting, including the sheep," and the Jewish scripts are critical of this. The Book of Jonah also highlights the sometimes unstable relationship between two religious needs: comfort and truth.


title: Jonah

text: Jonah is mentioned twice in the fourteenth chapter of the deuterocanonical Book of Tobit, the conclusion of which finds Tobit's son, Tobias, rejoicing at the news of Nineveh's destruction by Nebuchadnezzar and Ahasuerus in apparent fulfillment of Jonah's prophecy against the Assyrian capital.


title: Jonah

text: In the New Testament, Jonah is mentioned in the gospels of Matthew and Luke. In Matthew, Jesus makes a reference to Jonah when he is asked for a sign by some of the scribes and the Pharisees. Jesus says that the sign will be the sign of Jonah: Jonah's restoration after three days and three night inside the great fish prefigures His own resurrection.


title: Jonah

text: Jonah is regarded as a saint by a number of Christian denominations. His feast day in the Roman Catholic Church is on 21 September, according to the "Martyrologium Romanum". On the Eastern Orthodox liturgical calendar, Jonah's feast day is on 22 September (for those churches which follow the traditional Julian calendar; 22 September currently falls in October on the modern Gregorian calendar). In the Armenian Apostolic Church, moveable feasts are held in commemoration of Jonah as a single prophet and as one of the Twelve Minor Prophets. Jonah's mission to the Ninevites is commemorated by the Fast of Nineveh in Syriac and Oriental Orthodox Churches. Jonah is commemorated as a prophet in the Calendar of Saints of the Missouri Synod of the Lutheran Church on 22 September.


title: Jonah

text: Christian theologians have traditionally interpreted Jonah as a type for Jesus Christ. Jonah being in swallowed by the giant fish was regarded as a foreshadowing of Jesus's crucifixion and Jonah emerging from the fish after three days was seen as a parallel for Jesus emerging from the tomb after three days. Saint Jerome equates Jonah with Jesus's more nationalistic side, and justifies Jonah's actions by arguing that "Jonah acts thus as a patriot, not so much that he hates the Ninevites, as that he does not want to destroy his own people."


title: Jonah

text: Other Christian interpreters, including Saint Augustine and Martin Luther, have taken a directly opposite approach, regarding Jonah as the epitome of envy and jealousness, which they regarded as inherent characteristics of the Jewish people. Luther likewise concludes that the "kikayon" represents Judaism, and that the worm which devours it represents Christ. Luther also questioned the idea that the Book of Jonah was ever intended as literal history, commenting that he found it hard to believe that anyone would have interpreted it as such if it had never been included in the Bible. Luther's antisemitic interpretation of Jonah remained the prevailing interpretation among German Protestants throughout early modern history. J. D. Michaelis comments that "the meaning of the fable hits you right between the eyes", and concludes that the Book of Jonah is a polemic against "the Israelite people's hate and envy towards all the other nations of the earth." Albert Eichhorn was a strong supporter of Michaelis's interpretation.


title: Jonah

text: John Calvin and John Hooper regarded the Book of Jonah as a warning to all those who might attempt to flee from the wrath of God. While Luther had been careful to maintain that the Book of Jonah was not written by Jonah, Calvin declared that the Book of Jonah was Jonah's personal confession of guilt. Calvin sees Jonah's time inside the fish's belly as equivalent to the fires of Hell, intended to correct Jonah and set him on the path of righteousness. Also unlike Luther, Calvin finds fault with all the characters in the story, describing the sailors on the boat as "hard and iron-hearted, like Cyclops'", the penitence of the Ninevites as "untrained", and the king of Nineveh as a "novice". Hooper, on the other hand, sees Jonah as the archetypal dissident and the ship he is cast out from as a symbol of the state. Hooper deplores such dissidents, decrying: "Can you live quietly with so many Jonasses? Nay then, throw them into the sea!" In the eighteenth century, German professors were forbidden from teaching that the Book of Jonah was anything other than a literal, historical account.


title: Jonah

text: Jonah () is the title of the tenth chapter of the Quran. Yūnus is traditionally viewed as highly important in Islam as a prophet who was faithful to God and delivered His messages. Jonah is the only one of Judaism's Twelve Minor Prophets to be named in the Quran. In and , Jonah is called Dhul-Nūn (; meaning "The One of the Fish"). In 4:163 and 6:86, he is referred to as "an apostle of Allah". Surah 37:139–148 retells the full story of Jonah:


title: Jonah

text: The Quran never mentions Jonah's father, but Muslim tradition teaches that Jonah was from the tribe of Benjamin and that his father was Amittai.


title: Jonah

text: Jonah is also mentioned in a few incidents during the lifetime of Muhammad. Quraysh sent their servant, Addas, to serve him grapes for sustenance. Muhammad asked Addas where he was from and the servant replied Nineveh. "The town of Jonah the just, son of Amittai!" Muhammad exclaimed. Addas was shocked because he knew that the pagan Arabs had no knowledge of the prophet Jonah. He then asked how Muhammad knew of this man. "We are brothers," Muhammad replied. "Jonah was a Prophet of God and I, too, am a Prophet of God." Addas immediately accepted Islam and kissed the hands and feet of Muhammad.


title: Jonah

text: One of the sayings attributed to Muhammad, in the collection of Imam Bukhari, says that Muhammad said "One should not say that I am better than Jonah". Umayya ibn Abi al-Salt, an older contemporary of Muhammad, taught that, had Jonah not prayed to Allah, he would have remained trapped inside the fish until Judgement Day, but, because of his prayer, Jonah "stayed only a few days within the belly of the fish".


title: Jonah

text: The ninth-century Persian historian Al-Tabari records that, while Jonah was inside the fish, "none of his bones or members were injured". Al-Tabari also writes that Allah made the body of the fish transparent, allowing Jonah to see the "wonders of the deep" and that Jonah heard all the fish singing praises to Allah. Kisai Marvazi, a tenth-century poet, records that Jonah's father was seventy years old when Jonah was born and that he died soon afterwards, leaving Jonah's mother with nothing but a wooden spoon, which turned out to be a cornucopia.


title: Jonah

text: Nineveh's current location is marked by excavations of five gates, parts of walls on four sides, and two large mounds: the hill of Kuyunjik and hill of Nabi Yunus. A mosque atop Nabi Yunus was dedicated to the prophet Jonah and contained a shrine, which was revered by both Muslims and Christians as the site of Jonah's tomb. The tomb was a popular pilgrimage site and a symbol of unity to Jews, Christians, and Muslims across the Middle East. On July 24, 2014, the Islamic State of Iraq and the Levant (ISIL) destroyed the mosque containing the tomb as part of a campaign to destroy religious sanctuaries it deemed to be idolatrous. After Mosul was taken back from ISIL in January 2017, an ancient Assyrian palace built by Esarhaddon dating to around the first half of the 7th century BCE was discovered beneath the ruined mosque. ISIL had plundered the palace of items to sell on the black market, but some of the artifacts that were more difficult to transport still remained in place.


title: Jonah

text: Other reputed locations of Jonah's tomb include the Arab village of Mashhad, located on the ancient site of Gath-hepher in Israel; the Palestinian West Bank town of Halhul, north of Hebron; and a sanctuary near the city of Sarafand (Sarepta) in Lebanon. Another tradition places the tomb at a hill now called Giv'at Yonah, "Jonah's Hill", at the northern edge of the Israeli town of Ashdod, at a site covered by a modern lighthouse.


title: Jonah

text: A tomb of Jonah can be found in Diyarbakir, Turkey, located behind the mihrab at . Evliya Çelebi states in his "Seyahatname" that he visited the tombs of prophet Jonah and prophet George in the city.


title: Jonah

text: The story of a man surviving after being swallowed by a whale or giant fish is classified in the catalogue of folktale types as ATU 1889G.


title: Jonah

text: Many Biblical scholars hold that the contents of the Book of Jonah are ahistorical. Although the prophet Jonah allegedly lived in the eighth century BCE, the Book of Jonah was written centuries later during the time of the Achaemenid Empire. The Hebrew used in the Book of Jonah shows strong influences from Aramaic and the cultural practices described in it match those of the Achaemenid Persians. Some scholars regard the Book of Jonah as an intentional work of parody or satire. If this is the case, then it was probably admitted into the canon of the Hebrew Bible by sages who misunderstood its satirical nature and mistakenly interpreted it as a serious prophetic work.


title: Jonah

text: While the Book of Jonah itself is considered fiction, Jonah himself may have been a historical prophet; he is briefly mentioned in the Second Book of Kings:


title: Jonah

text: The views expressed by Jonah in the Book of Jonah are a parody of views held by members of Jewish society at the time when it was written. The primary target of the satire may have been a faction whom Morton Smith calls "Separationists", who believed that God would destroy those who disobeyed him, that sinful cities would be obliterated, and that God's mercy did not extend to those outside the Abrahamic covenant. McKenzie and Graham remark that "Jonah is in some ways the most 'orthodox' of Israelite theologians – to make a theological point." Jonah's statements throughout the book are characterized by their militancy, but his name ironically means "dove", a bird which the ancient Israelites associated with peace.


title: Jonah

text: Jonah's rejection of God's commands is a parody of the obedience of the prophets described in other Old Testament writings. The king of Nineveh's instant repentance parodies the rulers throughout the other writings of the Old Testament who disregard prophetic warnings, such as Ahab and Zedekiah. The readiness to worship God displayed by the sailors on the ship and the people of Nineveh contrasts ironically with Jonah's own reluctance, as does Jonah's greater love for "kikayon" providing him shade than for all the people in Nineveh.


title: Jonah

text: The Book of Jonah also employs elements of literary absurdism; it exaggerates the size of the city of Nineveh to an implausible degree and incorrectly refers to the administrator of the city as a "king". According to scholars, no human being could realistically survive for three days inside a fish, and the description of the livestock in Nineveh fasting alongside their owners is "silly".


title: Jonah

text: The motif of a protagonist being swallowed by a giant fish or whale became a stock trope of later satirical writings. Similar incidents are recounted in Lucian of Samosata's "A True Story", which was written in the second century CE, and in the novel "Baron Munchausen's Narrative of his Marvellous Travels and Campaigns in Russia", published by Rudolf Erich Raspe in 1785.


title: Jonah

text: Though art and culture often depicts Jonah's fish as a whale, the Hebrew text, as throughout scripture, refers to no marine species in particular, simply saying "great fish" or "big fish" (modern taxonomists classify whales as mammals and not as fish, but cultures in antiquity made no such distinction). While some biblical scholars suggest the size and habits of the great white shark correspond better to the representations of Jonah's experiences, normally an adult human is too large to be swallowed whole. The development of whaling from the 18th century onwards made it clear that most, if not all, species of whale could not swallow a human, leading to much controversy about the veracity of the biblical story of Jonah.


title: Jonah

text: In Jonah 2:1 (1:17 in English translations), the Hebrew text reads "dag gadol" (דג גדול) or, in the Hebrew Masoretic Text, "dāḡ gā·ḏō·wl" (דָּ֣ג גָּד֔וֹל), which means "great fish". The Septuagint translates this phrase into Greek as "kētei megalōi" (κήτει μεγάλῳ), meaning "huge fish". In Greek mythology, the same word meaning "fish" ("kêtos") is used to describe the sea monster slain by the hero Perseus that nearly devoured the Princess Andromeda. Jerome later translated this phrase as "piscis grandis" in his Latin Vulgate. He translated "kétos", however, as "ventre ceti" in Matthew 12:40: this second case occurs only in this verse of the New Testament.


title: Jonah

text: At some point "cetus" became synonymous with "whale" (the study of whales is now called "cetology"). In his 1534 translation, William Tyndale translated the phrase in Jonah 2:1 as "greate fyshe" and the word "kétos" (Greek) or "cetus" (Latin) in Matthew 12:40 as "whale". Tyndale's translation was later incorporated into the Authorized Version of 1611. Since then, the "great fish" in Jonah 2 has been most often interpreted as a whale. In English some translations use the word "whale" for Matthew 12:40, while others use "sea creature" or "big fish".


title: Jonah

text: In the seventeenth and eighteenth centuries, naturalists, interpreting the Jonah story as a historical account, became obsessed with trying to identify the exact species of the fish that swallowed Jonah. In the mid-nineteenth century, Edward Bouverie Pusey, professor of Hebrew at Oxford University, claimed that the Book of Jonah must have been authored by Jonah himself and argued that the fish story must be historically true, or else it would not have been included in the Bible. Pusey attempted to scientifically catalogue the fish, hoping to "shame those who speak of the miracle of Jonah's preservation in the fish as a thing less credible than any of God's other miraculous doings".


title: Jonah

text: The debate over the fish in the Book of Jonah played a major role during Clarence Darrow's cross-examination of William Jennings Bryan at the Scopes Trial in 1925. Darrow asked Bryan "When you read that ... the whale swallowed Jonah ... how do you literally interpret that?" Bryan replied that he believed in "a God who can make a whale and can make a man and make both of them do what He pleases." Bryan ultimately admitted that it was necessary to interpret the Bible, and is generally regarded as having come off looking like a "buffoon".


title: Jonah

text: The largest of all whales – blue whales – are baleen whales which eat plankton; and "it is commonly said that this species would be choked if it attempted to swallow a herring."


title: Jonah

text: As for the whale shark, Dr. E. W. Gudger, an Honorary Associate in Ichthyology at the American Museum of Natural History, notes that, while the whale shark does have a large mouth, its throat is only four inches wide, with a sharp elbow or bend behind the opening, meaning that not even a human arm would be able to pass through it. He concludes that "the whale shark is not the fish that swallowed Jonah."


title: Jonah

text: Sperm whales, however, appear to be a different matter: They regularly eat giant squid, so presumably one could swallow a human. Similar to a cow, sperm whales have four-chambered stomachs. The first chamber has no gastric juices but has muscular walls to crush its food. On the other hand, it is not possible to breathe inside the sperm whale's stomach because there is no air (but probably methane instead).


title: Jonah

text: In Turkish, "Jonah fish" (in Turkish "yunus baligi") is the term used for dolphins. A long-established expression among sailors uses the term, "a Jonah", to mean a sailor or a passenger whose presence on board brings bad luck and endangers the ship. Later, this meaning was extended to mean, "a person who carries a jinx, one who will bring bad luck to any enterprise."


title: Jonah

text: Despite its brevity, the Book of Jonah has been adapted numerous times in literature and in popular culture. In Herman Melville's "Moby-Dick" (1851), Father Mapple delivers a sermon on the Book of Jonah. Mapple asks why Jonah does not show remorse for disobeying God while he is inside of the fish. He comes to the conclusion that Jonah admirably understands that "his dreadful punishment is just." Carlo Collodi's "The Adventures of Pinocchio" (1883) features the title character and his father Geppetto being swallowed by "the Terrible Dogfish," an allusion to the story of Jonah. Walt Disney's 1940 film adaptation of the novel retains this allusion. The story of Jonah was adapted into Phil Vischer and Mike Nawrocki's animated film "" (2002). In the film, Jonah is swallowed by a gargantuan whale. The film was Big Idea Entertainment's first full-length theatrical release and it earned approximately $6.5 million on its first weekend.


title: Jonah

text: Joseph Campbell suggests that the story of Jonah parallels a scene from the "Epic of Gilgamesh", in which Gilgamesh obtains a plant from the bottom of the sea. In the Book of Jonah, a worm (in Hebrew "tola'ath", "maggot") bites the shade-giving plant's root causing it to wither; whereas in the "Epic of Gilgamesh", Gilgamesh ties stones to his feet and plucks his plant from the floor of the sea. Once he returns to the shore, the rejuvenating plant is eaten by a serpent.


title: Jonah

text: Campbell also noted several similarities between the story of Jonah and that of Jason in Greek mythology. The Greek rendering of the name Jonah is "Jonas" (Ἰωνᾶς), which differs from "Jason" (Ἰάσων) only in the order of sounds—both "o"s are omegas suggesting that Jason may have been confused with Jonah. Gildas Hamel, drawing on the Book of Jonah and Greco-Roman sources—including Greek vases and the accounts of Apollonius of Rhodes, Gaius Valerius Flaccus and Orphic Argonautica—identifies a number of shared motifs, including the names of the heroes, the presence of a dove, the idea of "fleeing" like the wind and causing a storm, the attitude of the sailors, the presence of a sea-monster or dragon threatening the hero or swallowing him, and the form and the word used for the "gourd" ("kikayon").


title: Jonah

text: Hamel takes the view that it was the Hebrew author who reacted to and adapted this mythological material to communicate his own, quite different message.


title: Sam Morril

text: Morril grew up in New York City, the son of Ashkenazi Jewish parents. His mother, Marilyn Greenberg, is a painter and his stepfather is publishing industry attorney Mark Charles Morril. His maternal grandfather was George Greenberg, the former CEO of Loehmann's clothing store chain. In 1993, when he was seven years old, his mother and stepfather married and he thus adopted the Morril surname. He has two step-siblings. Through his biological father, whose surname is Elgort, Morril is the nephew of fashion photographer Arthur Elgort and the cousin of actor and singer Ansel Elgort. He attended the Browning School in Manhattan, and later graduated from Tulane University in New Orleans.


title: Sam Morril

text: Morril was named one of Comedy Central's "Comics to Watch" in 2011 and has worked with comedians including Dave Attell, Marc Maron, Conan O'Brien, and Amy Schumer. He worked as an intern on "The Colbert Report" and later appeared on "The Late Show with Stephen Colbert" in April 2016. He has also made multiple appearances on "Conan" since 2014. He performed his stand-up routine on "America's Got Talent" in 2016, but did not win. His first one-hour special, "Positive Influence", was released by Comedy Central in September 2018. His second one-hour special, "I Got This", was released via Comedy Central's YouTube channel in February 2020. He is a regular on Comedy Central's "This Week at the Comedy Cellar", performing frequently when not on tour. He had a cameo appearance as a comedian at an open mic night in the DC thriller film "Joker" (2019). He co-hosts the weekly podcast We Might be Drunk with comedian Mark Normand.


title: Thalassemia

text: Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.


title: Thalassemia

text: Thalassemias are genetic disorders inherited from a person's parents. There are two main types, alpha thalassemia and beta thalassemia. The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing. Diagnosis is typically by blood tests including a complete blood count, special hemoglobin tests, and genetic tests. Diagnosis may occur before birth through prenatal testing.


title: Thalassemia

text: Treatment depends on the type and severity. Treatment for those with more severe disease often includes regular blood transfusions, iron chelation, and folic acid. Iron chelation may be done with deferoxamine, deferasirox or deferiprone. Occasionally, a bone marrow transplant may be an option. Complications may include iron overload from the transfusions with resulting heart or liver disease, infections, and osteoporosis. If the spleen becomes overly enlarged, surgical removal may be required. Thalassemia patients who do not respond well to blood transfusions can take hydroxyurea or thalidomide, and sometimes a combination of both. Hydroxyurea is the only FDA approved drug for thalassemia. Patients who took 10 mg/kg of hydroxyurea every day for a year had significantly higher hemoglobin levels, and it was a well-tolerated treatment for patients who did not respond well to blood transfusions. Another hemoglobin-inducer includes thalidomide, although it has not been tested in a clinical setting. The combination of thalidomide and hydroxyurea resulted in hemoglobin levels increasing significantly in transfusion-dependent and non-transfusion dependent patients


title: Thalassemia

text: As of 2015, thalassemia occurs in about 280 million people, with about 439,000 having severe disease. It is most common among people of Greek, Italian, Middle Eastern, South Asian, and African descent. Males and females have similar rates of disease. It resulted in 16,800 deaths in 2015, down from 36,000 deaths in 1990. Those who have minor degrees of thalassemia, similar to those with sickle-cell trait, have some protection against malaria, explaining why they are more common in regions of the world where malaria exists.


title: Thalassemia

text: Normal human hemoglobins are tetrameric proteins composed of two pairs of globin chains, each of which contains one alpha-like (α-like) chain and one beta-like (β-like) chain. Each globin chain is associated with an iron-containing heme moiety. Throughout life, the synthesis of the alpha-like and the beta-like (also called non-alpha-like) chains is balanced so that their ratio is relatively constant and there is no excess of either type.


title: Thalassemia

text: The specific alpha and beta-like chains that are incorporated into Hb are highly regulated during development:


title: Thalassemia

text: Both α- and β-thalassemias are often inherited in an autosomal recessive manner. Cases of dominantly inherited α- and β-thalassemias have been reported, the first of which was in an Irish family with two deletions of 4 and 11 bp in exon 3 interrupted by an insertion of 5 bp in the β-globin gene. For the autosomal recessive forms of the disease, both parents must be carriers for a child to be affected. If both parents carry a hemoglobinopathy trait, the risk is 25% for each pregnancy for an affected child.


title: Thalassemia

text: The genes involved in thalassemia control the production of healthy hemoglobin. Hemoglobin binds oxygen in the lungs and releases it when the red cells reach peripheral tissues, such as the liver. The binding and release of oxygen by hemoglobin are essential for survival.


title: Thalassemia

text: Having a single genetic variant for thalassemia may protect against malaria and thus can be an advantage.


title: Thalassemia

text: People diagnosed with heterozygous (carrier) β-thalassemia have some protection against coronary heart disease.


title: Thalassemia

text: Normally, the majority of adult hemoglobin (HbA) is composed of four protein chains, two α and two β-globin chains arranged into a heterotetramer. In thalassemia, patients have defects in either the α or β-globin chain, causing production of abnormal red blood cells.


title: Thalassemia

text: The thalassemias are classified according to which chain of the hemoglobin molecule is affected. In α-thalassemias, production of the α-globin chain is affected, while in β-thalassemia, production of the β-globin chain is affected.


title: Thalassemia

text: The β-globin chains are encoded by a single gene on chromosome 11; α-globin chains are encoded by two closely linked genes on chromosome 16. Thus, in a normal person with two copies of each chromosome, two loci encode the β chain, and four loci encode the α chain. Deletion of one of the α loci has a high prevalence in people of African or Asian descent, making them more likely to develop α-thalassemia. β-Thalassemias are not only common in Africans, but also in Greeks and Turks.


title: Thalassemia

text: The α-thalassemias involve the genes "HBA1" and "HBA2", inherited in a Mendelian recessive fashion. Two gene loci and so four alleles exist. Two genetic loci exist for α-globin, thus four alleles are in diploid cells. Two alleles are maternal and two alleles are paternal in origin. The severity of the α-thalassemias is correlated with the number of affected α-globin; alleles: the greater, the more severe will be the manifestations of the disease. Alpha-thalassemias result in decreased alpha-globin production; therefore, fewer alpha-globin chains are produced, resulting in an excess of β chains in adults and excess γ chains in newborns. The excess β chains form unstable tetramers (called hemoglobin H or HbH of 4 beta chains), which have abnormal oxygen dissociation curves. Alpha thalassemias often are found in people from Southeast Asia, the Middle East, China, and in those of African descent.


title: Thalassemia

text: Beta thalassemias are due to mutations in the "HBB gene" on chromosome 11, also inherited in an autosomal, recessive fashion. The severity of the disease depends on the nature of the mutation and on the presence of mutations in one or both alleles.


title: Thalassemia

text: Mutated alleles are called β when partial function is conserved (either the protein has a reduced function, or it functions normally but is produced in reduced quantity) or β, when no functioning protein is produced.


title: Thalassemia

text: Beta thalassemia most often occurs in people of Mediterranean origin. To a lesser extent, Chinese, other Asians, and African Americans can be affected.


title: Thalassemia

text: As well as alpha and beta chains present in hemoglobin, about 3% of adult hemoglobin is made of alpha and delta chains. Just as with beta thalassemia, mutations that affect the ability of this gene to produce delta chains can occur.


title: Thalassemia

text: Thalassemia can be diagnosed via a complete blood count, hemoglobin electrophoresis or high-performance liquid chromatography, and DNA testing. Hemoglobin electrophoresis is not widely available in developing countries, but the Mentzer index can also be used for diagnosis of thalassemia; it is not a definitive test but it can suggest the possibility of thalassemia. The Mentzer index can be calculated from a complete blood count report.


title: Thalassemia

text: The American College of Obstetricians and Gynecologists recommends all people thinking of becoming pregnant be tested to see if they have thalassemia. Genetic counseling and genetic testing are recommended for families who carry a thalassemia trait.


title: Thalassemia

text: A screening policy exists in Cyprus to reduce the rate of thalassemia, which, since the program's implementation in the 1970s (also including prenatal screening and abortion), has reduced the number of children born with the disease from one of every 158 births to almost zero. Greece also has a screening program to identify people who are carriers.


title: Thalassemia

text: In Iran as a premarital screening, the man's red cell indices are checked first. If he has microcytosis (mean cell hemoglobin < 27 pg or mean red cell volume < 80 fl), the woman is tested. When both are microcytic, their hemoglobin A2 concentrations are measured. If both have a concentration above 3.5% (diagnostic of thalassemia trait) they are referred to the local designated health post for genetic counseling.


title: Thalassemia

text: Large-scale awareness campaigns are being organized in India both by government and non-government organizations to promote voluntary premarital screening, with marriage between carriers strongly discouraged.


title: Thalassemia

text: Mild thalassemia: people with thalassemia traits do not require medical or follow-up care after the initial diagnosis is made. People with β-thalassemia trait should be warned that their condition can be misdiagnosed as the more common iron-deficiency anemia. They should avoid routine use of iron supplements, but iron deficiency may develop during pregnancy or from chronic bleeding. Counseling is indicated for all persons with genetic disorders, especially when the family is at risk of a severe form of disease that may be prevented.


title: Thalassemia

text: People with severe thalassemia require medical treatment. A blood transfusion regimen is the first effective measure in prolonging life.


title: Thalassemia

text: There is some evidence that growth hormone replacement therapy may help to increase the rate at which children with thalassemia grow taller.


title: Thalassemia

text: Multiple blood transfusions may result in iron overload. The iron overload related to thalassemia may be treated by chelation therapy with the medications deferoxamine, deferiprone, or deferasirox. These treatments have resulted in longer life expectancy for those with thalassemia major.


title: Thalassemia

text: Deferoxamine is only effective as a daily injection, complicating its long-term use. However, it is inexpensive and safe. Adverse effects include primary skin reactions around the injection site and hearing loss.


title: Thalassemia

text: Deferasirox and deferiprone are both oral medications, whose common side effects include nausea, vomiting and diarrhea. Deferasirox is not effective for all patients and may not be suitable for those with significant cardiac issues related to iron overload, while deferiprone appears to be the most effective agent when the heart is involved. Furthermore, the cost of deferasirox is also significant.


title: Thalassemia

text: There is no evidence from randomized controlled trial to support zinc supplementation for those with thalassemia.


title: Thalassemia

text: Bone-marrow transplantation may offer the possibility of a cure in young people who have an HLA-matched donor. Success rates have reached the 80–90% range. Mortality from the procedure is about 3%. There are no randomized controlled trials that have tested the safety and efficacy of non-identical donor bone-marrow transplantation in persons with β- thalassemia who are dependent on blood transfusion.


title: Thalassemia

text: Graft-versus-host diseases (GvHD) are one relevant side effect of bone-marrow transplantation. Further research is necessary to evaluate whether mesenchymal stromal cells can be used as prophylaxis or treatment for GvHD.


title: Thalassemia

text: If the patient does not have an HLA-matched compatible donor, bone-marrow transplantation from haploidentical mother to child (mismatched donor) may be attempted. In a study of 31 people, the thalassemia-free survival rate was 70%, rejection 23% and mortality 7%. The most positive results tend to occur with very young people.


title: Thalassemia

text: The beta form of thalassemia is particularly prevalent among Mediterranean peoples, and this geographical association is responsible for its original name. Thalassemia resulted in 25,000 deaths in 2013 down from 36,000 deaths in 1990.


title: Thalassemia

text: In Europe, the highest concentrations of the disease are found in Greece, coastal regions in Turkey (particularly the Aegean Region such as İzmir, Balıkesir, Aydın, Muğla, and Mediterranean Region such as Antalya, Adana, Mersin), in southern Spain, in parts of Italy, particularly southern Italy. With the exception of the Balearics, the major Mediterranean Islands, such as Sicily, Sardinia, Malta, Corsica, Cyprus, and Crete are heavily affected. Other Mediterranean peoples, as well as those in the vicinity of the Mediterranean, also have high rates of thalassemia, including people from North Africa and West Asia. Far from the Mediterranean, South Asians are also affected, with the world's highest concentration of carriers (16–18% of the population) in the Maldives.


title: Thalassemia

text: The disease is also found in populations living in Africa, the Americas, and in Tharu people in the Terai region of Nepal and India. It is believed to account for much lower rates of malaria illnesses and deaths, accounting for the historic ability of Tharus to survive in areas with heavy malaria infestation while others could not. Thalassemias are particularly associated with people of Mediterranean origin, Arabs (especially Palestinians and people of Palestinian descent), and Asians. The estimated prevalence is 16% in people from Cyprus, 1% in Thailand, and 3–8% in populations from Bangladesh, China, India, Malaysia and Pakistan.


title: Thalassemia

text: Estimates suggest that approximately 1.5% of the global population (80 – 90 million people) are β-thalassemia carriers. However, exact data on carrier rates in many populations are lacking, particularly in developing areas of the world known or expected to be heavily affected. Because of the prevalence of the disease in countries with little knowledge of thalassemia, access to proper treatment and diagnosis can be difficult. While there are some diagnostic and treatment facilities in developing countries, in most cases these are not provided by government services and are available only to patients who can afford them. In general, poorer populations only have access to limited diagnostic facilities and blood transfusions. In some developing countries, there are virtually no facilities for diagnosis or management of thalassemia.


title: Thalassemia

text: The word "thalassemia" () derives from the Greek " thalassa" (θάλασσα), "sea", and New Latin "-emia" (from the Greek compound stem -"aimia" (-αιμία), from "haima" (αἷμα), "blood"). It was coined because the condition called "Mediterranean anemia" was first described in people of Mediterranean ethnicities. "Mediterranean anemia" was renamed thalassemia major once the genetics were better understood. The word "thalassemia" was first used in 1932.


title: Thalassemia

text: In 2008, in Spain, a baby was selectively implanted to be a cure for his brother's thalassemia. The child was born from an embryo screened to be free of the disease before implantation with "in vitro" fertilization. The baby's supply of immunologically compatible cord blood was saved for transplantation to his brother. The transplantation was considered successful. In 2009, a group of doctors and specialists in Chennai and Coimbatore registered the successful treatment of thalassemia in a child using an unaffected sibling's umbilical cord blood.


title: Thalassemia

text: Gene therapy is being studied for thalassemia. The procedure involves collecting hematopoietic stem cells (HSCs) from the affected person's blood. The HSCs then have a beta-globin gene added using a lentiviral vector. After destroying the affected person's bone marrow with a dose of chemotherapy (a myeloablative conditioning regimen), the altered HSCs are infused back into the affected person where they become engrafted in the bone marrow where they proliferate. This potentially results in a progressive increase in hemoglobin A2 synthesis in all subsequent developing red blood cells, with resultant resolution of the anemia.


title: Thalassemia

text: While one person with beta thalassemia has no longer required blood transfusions following treatment within a research trial, it is not an approved treatment as of 2018.


title: Thalassemia

text: HbF induction is an attempt to reactivate fetal globin gene transcription. Efforts involve trying to disrupt the fetal globin gene promoter.


title: Lithography

text: Lithography () is a planographic method of printing originally based on the immiscibility of oil and water. The printing is from a stone (lithographic limestone) or a metal plate with a smooth surface. It was invented in 1796 by the German author and actor Alois Senefelder and was initially used mostly for musical scores and maps. Lithography can be used to print text or images onto paper or other suitable material. A lithograph is something printed by lithography, but this term is only used for fine art prints and some other, mostly older, types of printed matter, not for those made by modern commercial lithography.


title: Lithography

text: Originally, the image to be printed was drawn with a greasy substance, such as oil, fat, or wax onto the surface of a smooth and flat limestone plate. The stone was then treated with a mixture of weak acid and gum arabic ("etch") that made the parts of the stone's surface that were not protected by the grease more hydrophilic (water attracting). For printing, the stone was first moistened. The water only adhered to the gum-treated parts, making them even more oil-repellant. An oil-based ink was then applied, and would stick only to the original drawing. The ink would finally be transferred to a blank paper sheet, producing a printed page. This traditional technique is still used for fine art printmaking.


title: Lithography

text: In modern commercial lithography, the image is transferred or created as a patterned polymer coating applied to a flexible plastic or metal plate. The printing plates, whether stone or metal, can be created by a photographic process, a method that may be referred to as "photolithography" (although the term usually refers to a vaguely similar microelectronics manufacturing process). Offset printing or "offset lithography" is an elaboration of lithography in which the ink is transferred from the plate to the paper by means of a rubber plate or cylinder, rather than by direct contact of the two. This technique keeps the paper dry and allows high speed fully automated operation. It has mostly replaced traditional lithography for medium- and high-volume printing: since the 1960s, most books and magazines, especially when illustrated in colour, are printed with offset lithography from photographically created metal plates.


title: Lithography

text: As a printing technology, lithography is different from intaglio printing (gravure), wherein a plate is engraved, etched, or stippled to score cavities to contain the printing ink; and woodblock printing or letterpress printing, wherein ink is applied to the raised surfaces of letters or images.


title: Lithography

text: Lithography uses simple chemical processes to create an image. For instance, the positive part of an image is a water-repelling ("hydrophobic") substance, while the negative image would be water-retaining ("hydrophilic"). Thus, when the plate is introduced to a compatible printing ink and water mixture, the ink will adhere to the positive image and the water will clean the negative image. This allows a flat print plate to be used, enabling much longer and more detailed print runs than the older physical methods of printing (e.g., intaglio printing, letterpress printing).


title: Lithography

text: Lithography was invented by Alois Senefelder in the Kingdom of Bavaria in 1796. In the early days of lithography, a smooth piece of limestone was used (hence the name "lithography": "lithos" () is the Ancient Greek word for "stone"). After the oil-based image was put on the surface, a solution of gum arabic in water was applied, the gum sticking only to the non-oily surface. During printing, water adhered to the gum arabic surfaces and was repelled by the oily parts, while the oily ink used for printing did the opposite.


title: Lithography

text: Lithography works because of the mutual repulsion of oil and water. The image is drawn on the surface of the print plate with a fat or oil-based medium (hydrophobic) such as a wax crayon, which may be pigmented to make the drawing visible. A wide range of oil-based media is available, but the durability of the image on the stone depends on the lipid content of the material being used, and its ability to withstand water and acid. After the drawing of the image, an aqueous solution of gum arabic, weakly acidified with nitric acid () is applied to the stone. The function of this solution is to create a hydrophilic layer of calcium nitrate salt, , and gum arabic on all non-image surfaces. The gum solution penetrates into the pores of the stone, completely surrounding the original image with a hydrophilic layer that will not accept the printing ink. Using lithographic turpentine, the printer then removes any excess of the greasy drawing material, but a hydrophobic molecular film of it remains tightly bonded to the surface of the stone, rejecting the gum arabic and water, but ready to accept the oily ink.


title: Lithography

text: When printing, the stone is kept wet with water. The water is naturally attracted to the layer of gum and salt created by the acid wash. Printing ink based on drying oils such as linseed oil and varnish loaded with pigment is then rolled over the surface. The water repels the greasy ink but the hydrophobic areas left by the original drawing material accept it. When the hydrophobic image is loaded with ink, the stone and paper are run through a press that applies even pressure over the surface, transferring the ink to the paper and off the stone.


title: Lithography

text: Senefelder had experimented during the early 19th century with multicolor lithography; in his 1819 book, he predicted that the process would eventually be perfected and used to reproduce paintings. Multi-color printing was introduced by a new process developed by Godefroy Engelmann (France) in 1837 known as chromolithography. A separate stone was used for each color, and a print went through the press separately for each stone. The main challenge was to keep the images aligned ("in register"). This method lent itself to images consisting of large areas of flat color, and resulted in the characteristic poster designs of this period.


title: Lithography

text: "Lithography, or printing from soft stone, largely took the place of engraving in the production of English commercial maps after about 1852. It was a quick, cheap process and had been used to print British army maps during the Peninsular War. Most of the commercial maps of the second half of the 19th century were lithographed and unattractive, though accurate enough."


title: Lithography

text: High-volume lithography is currently used to produce posters, maps, books, newspapers, and packaging—just about any smooth, mass-produced item with print and graphics on it. Most books, indeed all types of high-volume text, are now printed using offset lithography.


title: Lithography

text: For offset lithography, which depends on photographic processes, flexible aluminum, polyester, mylar or paper printing plates are used instead of stone tablets. Modern printing plates have a brushed or roughened texture and are covered with a photosensitive emulsion. A photographic negative of the desired image is placed in contact with the emulsion and the plate is exposed to ultraviolet light. After development, the emulsion shows a reverse of the negative image, which is thus a duplicate of the original (positive) image. The image on the plate emulsion can also be created by direct laser imaging in a CTP (computer-to-plate) device known as a platesetter. The positive image is the emulsion that remains after imaging. Non-image portions of the emulsion have traditionally been removed by a chemical process, though in recent times, plates have become available that do not require such processing.


title: Lithography

text: The plate is affixed to a cylinder on a printing press. Dampening rollers apply water, which covers the blank portions of the plate but is repelled by the emulsion of the image area. Hydrophobic ink, which is repelled by the water and only adheres to the emulsion of the image area, is then applied by the inking rollers.


title: Lithography

text: If this image were transferred directly to paper, it would create a mirror-type image and the paper would become too wet. Instead, the plate rolls against a cylinder covered with a rubber "blanket", which squeezes away the water, picks up the ink and transfers it to the paper with uniform pressure. The paper passes between the blanket cylinder and a counter-pressure or impression cylinder and the image is transferred to the paper. Because the image is first transferred, or "offset" to the rubber blanket cylinder, this reproduction method is known as "offset lithography" or "offset printing".


title: Lithography

text: Many innovations and technical refinements have been made in printing processes and presses over the years, including the development of presses with multiple units (each containing one printing plate) that can print multi-color images in one pass on both sides of the sheet, and presses that accommodate continuous rolls ("webs") of paper, known as web presses. Another innovation was the continuous dampening system first introduced by Dahlgren, instead of the old method (conventional dampening) which is still used on older presses, using rollers covered with molleton (cloth) that absorbs the water. This increased control of the water flow to the plate and allowed for better ink and water balance. Current dampening systems include a "delta effect or vario", which slows the roller in contact with the plate, thus creating a sweeping movement over the ink image to clean impurities known as "hickies".


title: Lithography

text: This press is also called an ink pyramid because the ink is transferred through several layers of rollers with different purposes. Fast lithographic 'web' printing presses are commonly used in newspaper production.


title: Lithography

text: The advent of desktop publishing made it possible for type and images to be modified easily on personal computers for eventual printing by desktop or commercial presses. The development of digital imagesetters enabled print shops to produce negatives for platemaking directly from digital input, skipping the intermediate step of photographing an actual page layout. The development of the digital platesetter during the late 20th century eliminated film negatives altogether by exposing printing plates directly from digital input, a process known as computer-to-plate printing.


title: Lithography

text: During the first years of the 19th century, lithography had only a limited effect on printmaking, mainly because technical difficulties remained to be overcome. Germany was the main center of production in this period. Godefroy Engelmann, who moved his press from Mulhouse to Paris in 1816, largely succeeded in resolving the technical problems, and during the 1820s lithography was adopted by artists such as Delacroix and Géricault. After early experiments such as "Specimens of Polyautography" (1803), which had experimental works by a number of British artists including Benjamin West, Henry Fuseli, James Barry, Thomas Barker of Bath, Thomas Stothard, Henry Richard Greville, Richard Cooper, Henry Singleton, and William Henry Pyne, London also became a center, and some of Géricault's prints were in fact produced there. Goya in Bordeaux produced his last series of prints by lithography—"The Bulls of Bordeaux" of 1828. By the mid-century the initial enthusiasm had somewhat diminished in both countries, although the use of lithography was increasingly favored for commercial applications, which included the prints of Daumier, published in newspapers. Rodolphe Bresdin and Jean-François Millet also continued to practice the medium in France, and Adolph Menzel in Germany. In 1862 the publisher Cadart tried to initiate a portfolio of lithographs by various artists, which was not successful but included several prints by Manet. The revival began during the 1870s, especially in France with artists such as Odilon Redon, Henri Fantin-Latour and Degas producing much of their work in this manner. The need for strictly limited editions to maintain the price had now been realized, and the medium became more accepted.


title: Lithography

text: In the 1890s, color lithography gained success in part by the emergence of Jules Chéret, known as the "father of the modern poster", whose work went on to inspire a new generation of poster designers and painters, most notably Toulouse-Lautrec, and former student of Chéret, Georges de Feure. By 1900 the medium in both color and monotone was an accepted part of printmaking.


title: Lithography

text: During the 20th century, a group of artists, including Braque, Calder, Chagall, Dufy, Léger, Matisse, Miró, and Picasso, rediscovered the largely undeveloped artform of lithography thanks to the Mourlot Studios, also known as "Atelier Mourlot", a Parisian printshop founded in 1852 by the Mourlot family. The Atelier Mourlot originally specialized in the printing of wallpaper; but it was transformed when the founder's grandson, Fernand Mourlot, invited a number of 20th-century artists to explore the complexities of fine art printing. Mourlot encouraged the painters to work directly on lithographic stones in order to create original artworks that could then be executed under the direction of master printers in small editions. The combination of modern artist and master printer resulted in lithographs that were used as posters to promote the artists' work.


title: Lithography

text: Grant Wood, George Bellows, Alphonse Mucha, Max Kahn, Pablo Picasso, Eleanor Coen, Jasper Johns, David Hockney, Susan Dorothea White, and Robert Rauschenberg are a few of the artists who have produced most of their prints in the medium. M. C. Escher is considered a master of lithography, and many of his prints were created using this process. More than other printmaking techniques, printmakers in lithography still largely depend on access to good printers, and the development of the medium has been greatly influenced by when and where these have been established.


title: Lithography

text: As a special form of lithography, the serilith or seriolithograph process is sometimes used. Seriliths are mixed-media original prints created in a process in which an artist uses the lithograph and serigraph (screen printing) Fine art prints of this type are published by numerous artists and publishers worldwide, and are widely accepted and collected. The separations for both processes are hand-drawn by the artist. The serilith technique is used primarily to create fine art limited print editions.


title: Heat death of the universe

text: The heat death of the universe (also known as the Big Chill or Big Freeze) is a hypothesis on the ultimate fate of the universe, which suggests the universe will evolve to a state of no thermodynamic free energy and will, therefore, be unable to sustain processes that increase entropy. Heat death does not imply any particular absolute temperature; it only requires that temperature differences or other processes may no longer be exploited to perform work. In the language of physics, this is when the universe reaches thermodynamic equilibrium. The Heat Death theory has become the leading theory in the modern age with the fewest unpredictable factors.


title: Heat death of the universe

text: If the topology of the universe is open or flat, or if dark energy is a positive cosmological constant (both of which are consistent with current data), the universe will continue expanding forever, and a heat death is expected to occur, with the universe cooling to approach equilibrium at a very low temperature after a very long time period.


title: Heat death of the universe

text: The hypothesis of heat death stems from the ideas of Lord Kelvin, who in the 1850s took the theory of heat as mechanical energy loss in nature (as embodied in the first two laws of thermodynamics) and extrapolated it to larger processes on a universal scale. This also allowed Kelvin to formulate the heat death paradox, which disproves an infinitely old universe.


title: Heat death of the universe

text: The idea of heat death stems from the second law of thermodynamics, of which one version states that entropy tends to increase in an isolated system. From this, the hypothesis implies that if the universe lasts for a sufficient time, it will asymptotically approach a state where all energy is evenly distributed. In other words, according to this hypothesis, there is a tendency in nature to the dissipation (energy transformation) of mechanical energy (motion) into thermal energy; hence, by extrapolation, there exists the view that, in time, the mechanical movement of the universe will run down as work is converted to heat because of the second law.


title: Heat death of the universe

text: The conjecture that all bodies in the universe cool off, eventually becoming too cold to support life, seems to have been first put forward by the French astronomer Jean Sylvain Bailly in 1777 in his writings on the history of astronomy and in the ensuing correspondence with Voltaire. In Bailly's view, all planets have an internal heat and are now at some particular stage of cooling. Jupiter, for instance, is still too hot for life to arise there for thousands of years, while the Moon is already too cold. The final state, in this view, is described as one of "equilibrium" in which all motion ceases.


title: Heat death of the universe

text: The idea of heat death as a consequence of the laws of thermodynamics, however, was first proposed in loose terms beginning in 1851 by Lord Kelvin (William Thomson), who theorized further on the mechanical energy loss views of Sadi Carnot (1824), James Joule (1843) and Rudolf Clausius (1850). Thomson's views were then elaborated over the next decade by Hermann von Helmholtz and William Rankine.


title: Heat death of the universe

text: The idea of heat death of the universe derives from discussion of the application of the first two laws of thermodynamics to universal processes. Specifically, in 1851, Lord Kelvin outlined the view, as based on recent experiments on the dynamical theory of heat: "heat is not a substance, but a dynamical form of mechanical effect, we perceive that there must be an equivalence between mechanical work and heat, as between cause and effect."


title: Heat death of the universe

text: In 1852, Thomson published "On a Universal Tendency in Nature to the Dissipation of Mechanical Energy", in which he outlined the rudiments of the second law of thermodynamics summarized by the view that mechanical motion and the energy used to create that motion will naturally tend to dissipate or run down. The ideas in this paper, in relation to their application to the age of the Sun and the dynamics of the universal operation, attracted the likes of William Rankine and Hermann von Helmholtz. The three of them were said to have exchanged ideas on this subject. In 1862, Thomson published "On the age of the Sun's heat", an article in which he reiterated his fundamental beliefs in the indestructibility of energy (the first law) and the universal dissipation of energy (the second law), leading to diffusion of heat, cessation of useful motion (work), and exhaustion of potential energy, ""lost irrecoverably"" through the material universe, while clarifying his view of the consequences for the universe as a whole. Thomson wrote:


title: Heat death of the universe

text: The clock's example shows how Kelvin was unsure whether the universe would eventually achieve thermodynamic equilibrium. Thompson later speculated that restoring the dissipated energy in ""vis viva"" and then usable work - and therefore revert the clock's direction, resulting in a ""rejuvenating universe"" - would require ""a creative act or an act possessing similar power"". Starting from this publication, Kelvin also introduced the heat death paradox (Kelvin's paradox), which disproves the classical concept of an infinitely old universe, since the universe has not achieved its thermodynamic equilibrium, thus further work and entropy production are still possible. The existence of stars and temperature differences can be considered an empirical proof that the universe is not infinitely old.


title: Heat death of the universe

text: In the years to follow both Thomson's 1852 and the 1862 papers, Helmholtz and Rankine both credited Thomson with the idea, along with his paradox, but read further into his papers by publishing views stating that Thomson argued that the universe will end in a ""heat death"" (Helmholtz), which will be the ""end of all physical phenomena"" (Rankine).


title: Heat death of the universe

text: Proposals about the final state of the universe depend on the assumptions made about its ultimate fate, and these assumptions have varied considerably over the late 20th century and early 21st century. In a hypothesized "open" or "flat" universe that continues expanding indefinitely, either a heat death or a Big Rip is expected to eventually occur. If the cosmological constant is zero, the universe will approach absolute zero temperature over a very long timescale. However, if the cosmological constant is positive, the temperature will asymptote to a non-zero positive value, and the universe will approach a state of maximum entropy in which no further work is possible.


title: Heat death of the universe

text: From the Big Bang through the present day, matter and dark matter in the universe are thought to have been concentrated in stars, galaxies, and galaxy clusters, and are presumed to continue to do so well into the future. Therefore, the universe is not in thermodynamic equilibrium, and objects can do physical work. The decay time for a supermassive black hole of roughly 1 galaxy mass (10 solar masses) because of Hawking radiation is in the order of 10 years, so entropy can be produced until at least that time. Some large black holes in the universe are predicted to continue to grow up to perhaps 10 during the collapse of superclusters of galaxies. Even these would evaporate over a timescale of up to 10 years. After that time, the universe enters the so-called Dark Era and is expected to consist chiefly of a dilute gas of photons and leptons. With only very diffuse matter remaining, activity in the universe will have tailed off dramatically, with extremely low energy levels and extremely long timescales. Speculatively, it is possible that the universe may enter a second inflationary epoch, or assuming that the current vacuum state is a false vacuum, the vacuum may decay into a lower-energy state. It is also possible that entropy production will cease and the universe will reach heat death.


title: Heat death of the universe

text: It is suggested that, over vast periods of time, a spontaneous entropy "decrease" would eventually occur via the Poincaré recurrence theorem, thermal fluctuations, and fluctuation theorem. Through this, another universe could possibly be created by random quantum fluctuations or quantum tunnelling in roughly formula_1 years. Such a scenario, however, has been described as "highly speculative, probably wrong, [and] completely untestable". Sean M. Carroll, originally an advocate of this idea, no longer supports it, arguing that the virtual particles produced by quantum fluctuation cannot become real particles without an external input of energy.


title: Heat death of the universe

text: Max Planck wrote that the phrase "entropy of the universe" has no meaning because it admits of no accurate definition. In 2008, Walter Grandy wrote: "It is rather presumptuous to speak of the entropy of a universe about which we still understand so little, and we wonder how one might define thermodynamic entropy for a universe and its major constituents that have never been in equilibrium in their entire existence." According to Tisza: "If an isolated system is not in equilibrium, we cannot associate an entropy with it." Buchdahl writes of "the entirely unjustifiable assumption that the universe can be treated as a closed thermodynamic system". According to Gallavotti: "... there is no universally accepted notion of entropy for systems out of equilibrium, even when in a stationary state." Discussing the question of entropy for non-equilibrium states in general, Lieb and Yngvason express their opinion as follows: "Despite the fact that most physicists believe in such a nonequilibrium entropy, it has so far proved impossible to define it in a clearly satisfactory way." In Landsberg's opinion: "The "third" misconception is that thermodynamics, and in particular, the concept of entropy, can without further enquiry be applied to the whole universe. ... These questions have a certain fascination, but the answers are speculations."


title: Heat death of the universe

text: A 2010 analysis of entropy states, "The entropy of a general gravitational field is still not known", and "gravitational entropy is difficult to quantify." The analysis considers several possible assumptions that would be needed for estimates and suggests that the observable universe has more entropy than previously thought. This is because the analysis concludes that supermassive black holes are the largest contributor. Lee Smolin goes further: "It has long been known that gravity is important for keeping the universe out of thermal equilibrium. Gravitationally bound systems have negative specific heat—that is, the velocities of their components increase when energy is removed. ... Such a system does not evolve toward a homogeneous equilibrium state. Instead it becomes increasingly structured and heterogeneous as it fragments into subsystems." This point of view is also supported by the fact of a recent experimental discovery of a stable non-equilibrium steady state in a relatively simple closed system. It should be expected that an isolated system fragmented into subsystems does not necessarily come to thermodynamic equilibrium and remain in non-equilibrium steady state. Entropy will be transmitted from one subsystem to another, but its production will be zero, which does not contradict the second law of thermodynamics.


title: Heat death of the universe

text: In Isaac Asimov's 1956 short story "The Last Question", humans repeatedly wonder how can the heat death of the universe be avoided.


title: Heat death of the universe

text: In the 1995 computer game "I Have No Mouth, and I Must Scream", based on the Harlan Ellison short story of the same name, it is stated that AM, the malevolent supercomputer, will survive the heat death of the universe and continue torturing its immortal victims to eternity.


title: Heat death of the universe

text: In the 2011 anime series "Puella Magi Madoka Magica", the antagonist Kyubey reveals he is a member of an alien race who has been creating magical girls for millennia in order to harvest their energy to combat entropy and stave off the heat death of the universe.


title: Heat death of the universe

text: In the last act of "", the player encounters an alien race known as the Ea who have lost all hope in the future and any desire to live further, all because they have learned of the eventual heat death of the universe and see everything else as pointless due to its probable inevitability.


title: Dawn of the Dead (1978 film)

text: Dawn of the Dead is a 1978 zombie horror film written, directed, and edited by George A. Romero, and produced by Richard P. Rubinstein. An American-Italian international co-production, it is the second film in Romero's series of zombie films, and though it contains no characters or settings from the preceding film "Night of the Living Dead" (1968), it shows the larger-scale effects of a zombie apocalypse on society. In the film, a phenomenon of unidentified origin has caused the reanimation of the dead, who prey on human flesh. David Emge, Ken Foree, Scott Reiniger, and Gaylen Ross star as survivors of the outbreak who barricade themselves inside a suburban shopping mall amid mass hysteria.


title: Dawn of the Dead (1978 film)

text: Romero waited to make another zombie film after "Night of the Living Dead" for several years to avoid being stereotyped as a horror director. Upon visiting Monroeville Mall in Monroeville, Pennsylvania with a friend whose company managed the complex, he decided to use the location as the basis for the film's story. The project came to the attention of Italian filmmaker Dario Argento who, along with his brother Claudio and producer Alfredo Cuomo, agreed to co-finance the film in exchange for its international distribution rights. Argento also consulted with Romero during the scriptwriting phase. Principal photography on "Dawn of the Dead" took place between November 1977 and February 1978 on location in Monroeville and Pittsburgh. The special make-up effects were created by Tom Savini, whose work on the film led to an extensive career creating similar effects for other horror films. In post-production, Romero and Argento edited separate versions of the film for their respective markets. Argento's version features a progressive rock score composed and performed by his frequent collaborators Goblin, while Romero's cut primarily favors stock cues from the De Wolfe Music Library.


title: Dawn of the Dead (1978 film)

text: Following its Italian premiere on September 1, 1978, "Dawn of the Dead" was released in other markets the following year. Despite facing difficulties with various national censorship boards ― in the United States, it was released unrated to improve its commercial prospects after it was given an X by the Motion Picture Association of America, and in Britain it was liable for seizure during the 1980s "video nasties" moral panic ― the film proved to be a major success at the box office, grossing $66 million worldwide against its estimated budget of $640,000. Noted for its satirical portrayal of consumerism, "Dawn of the Dead" has received widespread critical acclaim since its initial release, and is widely considered to be one of the greatest horror films ever made, as well as the greatest zombie film. Like its predecessor, it has garnered a large, international cult following. In 2008, it was chosen by "Empire" magazine as one of "The 500 Greatest Movies of All Time", along with "Night of the Living Dead".


title: Dawn of the Dead (1978 film)

text: "Dawn of the Dead" was followed by four official sequels, beginning with 1985's "Day of the Dead", and a separate series of unofficial Italian-made sequels, beginning with 1979's "Zombi 2." It has also inspired a 2004 remake directed by Zack Snyder, as well as numerous parodies and pop culture references.


title: Dawn of the Dead (1978 film)

text: The United States is devastated by a mysterious plague that reanimates recently-dead human beings as flesh-eating ghouls. At the dawn of the crisis, it has been reported that millions of people have died and reanimated. Despite the government's best efforts, social order is collapsing. Rural communities and the National Guard have been effective in fighting the zombie hordes in open country, but urban centers descend into chaos.


title: Dawn of the Dead (1978 film)

text: At WGON TV, a television studio in Philadelphia, traffic reporter Stephen Andrews and his pregnant girlfriend, producer Fran Parker, are planning to steal the station's helicopter to escape the city. Across town, police SWAT officer Roger DeMarco and his team raid a low-income housing project, whose mostly African American and Latino tenants are defying the martial law of delivering their dead to the National Guard. The tenants and the officers exchange gunfire as the officers try to gain entry. Roger unsuccessfully tries to restrain Wooley, a brutal and racist officer, after he maniacally kills several unarmed civilians. Wooley is shot dead by an officer from another unit, Peter Washington. As the SWAT team dispatch the reanimated dead that have injured or killed several tenants, a disillusioned Roger suggests that he and Peter desert and join up with Stephen (who is Roger’s friend) in escaping the city. An elderly priest tells them that several zombies are confined in the basement. He also tells them that the SWAT team is stronger than the residents, but that soon the dead will be stronger than the SWAT team. The two go there and take on the grim job of eliminating all of them.


title: Dawn of the Dead (1978 film)

text: Later that night, Stephen discovers the dead body of a security operator who had been guarding a traffic helicopter belonging to his employer. Roger and Peter join Fran and Stephen at a police dock and then leave Philadelphia in the stolen helicopter. Following some close calls while stopping for fuel, the group comes across a shopping mall, and decide to remain there since there is plenty of food, medicine, and all kinds of consumables. Peter and Stephen camouflage the entrance to the stairwell which leads to their safe room, and they block the mall entrances with trucks to keep the undead from penetrating. This involves driving through crowds of zombies who are indifferent to their own injuries and attempt to enter the trucks. Roger survives a particularly dangerous encounter, and becomes reckless as a result. He is soon bitten by the zombies.


title: Dawn of the Dead (1978 film)

text: After clearing the mall's interior of zombies, the four enjoy a hedonistic lifestyle with all the goods available to them, furnishing their safe room with the mall's many commodities. Roger eventually succumbs to his wounds and dies; when he reanimates as a zombie, Peter shoots him in the head and later buries his body in the mall. Sometime later, all emergency broadcast transmissions cease, suggesting that the government has collapsed. Now isolated, the three load some supplies into the helicopter, in case they might need to leave suddenly. Fran gets Stephen to teach her how to fly in case he is killed or incapacitated.