we have used dnase i footprinting to identify 50 alpha-protein binding sites on simian virus 40 dna and thereby to determine the dna binding specificity of this mammalian nuclear protein . alpha-protein binds with approximately equal affinity to any run of six or more a x t base pairs in duplex dna , to many , if not all , runs of five a x t base pairs , and to a small number of other sequences within otherwise ( a + t ) -rich regions .
C0012940
protein binding
C1148673
dna binding