we conclude that the characteristic decrease in urine concentrating ability in cis-platinum nephrotoxicity is not primarily the result of an intrinsic abnormality in collecting duct function but is secondary to decreased papillary hypertonicity resulting from impaired function in more proximal nephron segments , presumably the pars recta of the proximal tubule and the loop of henle where previous studies have demonstrated abnormal function .
C0027713
nephron
C0023986
loop of henle