in 27 patients with reliably diagnosed wilson 's disease treated previously with penicillamine ( cuprenil , polfa ) for from 10 months to 12 years penicillamine was withdrawn due to various adverse effects and replaced with zinc sulphate ( polish preparation zincteral ) in doses of 200 mg 4 times daily for 12 months .
C0019202
wilson 's disease
C0030817
penicillamine