it was found that ( i ) measurement of serum paraprotein by specific radioimmunoassay is a sensitive method of monitoring the course of multiple and solitary myeloma , ( ii ) morphologically normal bone marrow from a multiple myeloma patient contained paraprotein-secreting plasma cells , ( iii ) a patient with benign monoclonal gammopathy had at least one stage in her disease where pre-plasmacytic tumour cells were present in the peripheral blood , ( iv ) the pbmc of the patients with active myeloma contained suppressor monocytes , and ( v ) pbmc from treated myeloma patients ( both those with still active disease and those in apparently complete remission ) would not secrete paraprotein in culture under a variety of different culture conditions including partial monocyte depletion .
C0032112
plasma cells
C0026470
benign monoclonal