1 ) age less than 2 years 2 ) involvement of spleen and/or lung 3 ) elevated lahey-score 4 ) dysfunction of the hematopoietic system , liver , and/or lung 5 ) histologic feature resembling malignant type 6 ) no response to therapy 7 ) severely affected general health .
C0037993
spleen
C0018957
hematopoietic system