at cellular level dmba treated animals showed keratinized cells with thick bundles of tonofilaments , broken basement membrane , wide intercellular spaces and loss of desmosomal attachments , whereas animals treated with dmba + retinoic acid showed decrease in the intercellular spaces , maintenance of basement membrane and intracellular organelles with suppression of keratinization , indicating the differentiating effect of retinoic acid on dmba transformed cells of hamster cheek pouch .
C0011703
desmosomal
C0007634
cells