to do this , an experimental variation of the parental tumor cell phenotype ( seed factor ) was performed by a selection of 10 times passaged hepatic-metastasizing tumor cells and changes in biological features of host tissue ( soil ) were induced following the treatment of the mice with ciclosporin , thymostimulin , bleomycin , silica particles or 17 alpha-ethynylestradiol prior to tumor injection .
C0027659
experimental
C0027651
tumor