measurement of insulin binding to insulin receptors isolated from the membrane fractions revealed that exposure of cells to insulin resulted in a loss of binding activity ( 13 % at 6 ng/ml , 27 % at 500 ng/ml insulin ) from the plasma membranes which was completely accounted for by the appearance of receptors in the low-density and high-density microsomal membrane fractions , indicating that insulin had induced translocation of insulin receptors from the surface to the cell interior .
C0007634
cells
C0007603
plasma