both nifedipine ( mean daily dose 70 +/- 23 mg ) and diltiazem ( mean daily dose 237 +/- 12 mg ) in combination with propranolol ( mean daily dose 146 +/- 58 mg ) resulted in significant increases in total exercise time , time to onset of angina and time to maximal st-segment depression compared with high dose diltiazem ( mean daily dose 347 +/- 38 mg ) monotherapy ( p less than or equal to 0.001 ) .
C0033497
propranolol
C0002962
angina