these nucleoside analogues exert a variety of pleiotropic effects , including polyclonal activation of b cells to secrete immunoglobulin , immunoenhancement of thymus-dependent and thymus-independent immune responses , induction of interleukin 1-like activity in cultured macrophages , and transmission of t cell-like inductive signals to b cells .
C1155003
activation
C0301872
immune responses