to examine the dose-dependent effects of saccharin on tumor promotion , sodium saccharin was administered at six levels in the diet ( 5.0 , 2.5 , 1.0 , 0.5 , 0.1 , and 0 % ) to female sprague-dawley rats which had received , by trans-urethral instillation into the bladder , either a single dose of saline or an initiating dose of n-methyl-n-nitrosourea ( mnu ) , a potent direct-acting carcinogen .
C0036023
saccharin
C0917900
sodium saccharin