between august 1977 and january 1979 , 16 children ( 7 males and 9 females ) ranging in age from 5 to 38 months ( mean age 18 months ) were treated with trimethoprim-sulfamethoxazole ( tmp-smx ) ( 40 mg/kg smx per 24 hours ) for otitis media caused by beta-lactamase strains of ampicillin-resistant haemophilus influenzae .
C0038689
smx
C0029882
otitis