add-3878 , administered as a dietary admixture ( 30-186 mg/kg/day ) to obese-diabetic yellow kk ( kk-ay ) mice , markedly suppressed the diabetic syndromes ( hyperglycemia , hypertriglyceridemia , and hyperinsulinemia ) , accompanied by the reduction of insulin resistance as manifested by improvement of overall insulin sensitivity in either the insulin tolerance test or the steady-state blood glucose test .
C0020459
hyperinsulinemia
C0021655
insulin resistance