the inhibition of acute lung anaphylaxis by aerosolized azelastine in the guinea pig asthma model may be due to ( 1 ) inhibition of the synthesis/release of chemical mediators , eg , histamine and leukotrienes , etc and/or ( 2 ) antagonism of the pharmacologic mediators at the receptor site in respiratory smooth muscles .
C0024109
lung
C0004096
asthma