objective responses were seen in 11 of 39 ( 28 % ) patients receiving the two higher doxorubicin-methotrexate treatment levels where doxorubicin dose was greater than 0.5 mg/kg/week compared to only 2 of 16 ( 12 % ) patients receiving lower doxorubicin levels ( p less than 0.05 ) , suggestive of a dose-response relationship .
C0281523
doxorubicin-methotrexate
C0013089
doxorubicin