it has been shown that icrf-159 [ 1,2-bis ( 3,5-dioxopiperazine-1-yl ) propane ] and its more water soluble d-enantiomer , icrf-186 , antagonize the toxicity of daunorubicin and the cardiac toxicity of daunorubicin and doxorubicin and potentiate the antitumor effect of both substances in experimental animals .
C0011015
daunorubicin
C0013089
doxorubicin