these data ( 1 ) demonstrate that in normal man fasted twelve to fourteen hours , glucagon at supraphysiologic levels can double the rate of gluconeogenesis from alanine and ( 2 ) indicate that this stimulatory effect of glucagon is exerted within the liver by shunting the extracted alanine toward new glucose formation rather than by increasing the hepatic extraction of alanine .
C0017715
gluconeogenesis
C0017725
glucose