angiotensin i converting enzyme ( ace ) was purified to homogeneity from porcine kidney in order to determine whether iodobradykinins bind to the enzyme and , if so , whether pglu-trp-pro-arg-pro-gin-ile-pro-pro , sq20881 , a competitive ace inhibitor , changes the conformation of the enzyme in such a way that it binds kinins with an affinity and specificity expected of a bradykinin ( bk ) receptor , i.e . where the bk potentiating action of sq20881 involves an increase in the number of bk receptors due to a conformational change in ace .
C0022714
kinins
C0006100
bk