we report here that , at cadmium concentrations 5 to 10-fold higher than that required to induce maximal transcription of the mt-1 gene , there is a 2 to 3-fold increase in mt-1 gene concentration in liver nuclear dna by 6 hours after induction , and extra copies persist up to 3 weeks in the absence of further heavy metal treatment .
C0006632
cadmium
C0347988
heavy metal