the pattern of histone acetylation obtained by in vitro reaction of purified nucleosomes with the purified nuclear acetylase a differed considerably from the corresponding patterns obtained either by acetate labeling of intact cells , or by the acetyl-coa labeling of nuclei and crude preparations of nucleosomes , as catalyzed by endogenous chromatin-bound acetylase ( s ) .
C0007610
nuclei
C0008546
chromatin