irrespective of their antigen dependency , these monoclonal antibodies activate t cells by a classical signal transduction pathway , in which the binding of monoclonal antibodies to their cell surface receptors leads to activation of phospholipase c resulting in the depolarization of plasma membrane , hydrolysis of ip2 and ip3 and dag , the 'second messengers ' .
C0034800
cell surface receptors
C0007603
plasma membrane