the effects of a variety of inhibitors on the internalization of transferrin and iron were investigated and three main effects were found : ( i ) sulphydryl reagents and microtubular inhibitors reduced the rate of transferrin and iron internalization to similar degrees , ( ii ) metabolic inhibitors reduced the rate of iron uptake more than that of transferrin endocytosis , and ( iii ) lysosomotrophic agents almost completely abolished iron accumulation by the cells without any effect on the rate of transferrin internalization .
C0014139
endocytosis
C0007634
cells