we conclude that exposure of adipocytes to insulin causes endocytosis of insulin receptors and activation of insulin receptor kinase , newly internalized receptors are fully active tyrosine kinases but are deactivated as they traverse the intracellular organelles represented by low-density and high-density microsomal membranes , and insulin receptor occupancy , possibly by stimulating phosphorylation and activating the insulin receptor kinase , is important for targeting insulin receptors for internalization .
C0033681
tyrosine kinases
C0031715
phosphorylation