oxidative metabolism by cytochromes p-450 is followed by conjugation and detoxication , whereas oxidative metabolism by cytochromes p-448 yields reactive intermediates which are not readily conjugated , and thus react with vital intracellular macromolecules , resulting in necrosis , redox cycling and oxygen radical formation , neoantigen production , and mutations .
C0010798
cytochromes
C0030012
redox