isoquinolinesulfonamides , inhibitors of protein kinases , caused no current responses and affected no receptor-mediated responses when injected into the oocytes at low doses ( 30-50 pmol ) , which inhibit cyclic nucleotide-dependent kinases or kinase c specifically , but abolished the receptor-mediated responses at a higher dose ( 300 pmol ) , which inhibit most protein kinases nonspecifically .
C0031727
kinase
C0033640
protein kinases