to assess the role of protein kinase-c ( pk-c ) in the growth and differentiation of small intestinal enterocytes , iec-6 cells ( a cell line derived from the crypts of rat small intestine ) were incubated with factors known to induce growth ( insulin , epidermal growth factor , gastrin , somatostatin and transferrin ) or differentiation ( transforming growth factor-beta , retinoic acid and phorbol 12-myristate 13-acetate ( pma ) ) .
C0007589
differentiation
C0040690
transforming growth factor-beta