the finding that the patterns of antioxidant enzyme alterations in chemically-induced diabetes are independent of the diabetogenic agent used and the presence of similar abnormalities in tissues of spontaneously diabetic ( bb ) wistar rats ( particularly when diabetic control is less than optimal ) suggest that the changes observed are a characteristic feature of the uncontrolled diabetic state and that these may be responsible for ( or predispose to ) the development of secondary complications in clinical diabetes .
C0037088
finding
C0009566
complications