acute administration of indomethacin , 5 mg/kg iv in anesthetized euvolemic , sprague-dawley rats with intact kidneys led to no significant alteration in renal hemodynamics , whereas in similarly prepared subtotally nephrectomized rats such inhibition significantly reduced remnant kidney glomerular filtration rate from 0.57 +/- 0.07 to 0.45 +/- 0.05 ml/min and single nephron glomerular filtration rate ( sngfr ) from 93 +/- 4 to 72 +/- 5 nl/min .
C0022646
kidney
C0027713
nephron