the cardiovascular effects were abolished by ganglionic blockade with hexamethonium.5 smaller doses of gbtx were required intra-arterially and intracerebroventricularly than by the intravenous route of injection to produce respiratory irregularity and cardiovascular hyperactivity.6 evoked motor responses , electrical excitability of the medulla oblongata and co ( 2 ) -ventilatory responsiveness were largely spared even though gbtx caused marked disturbances in respiratory rhythmicity and cardiovascular functions.7 it is concluded that gbtx acts reflexly on vagally innervated receptors to evoke a bezold-jarisch effect but that the toxin further acts centrally to cause irregular breathholding and hypertension with tachycardia , leading ultimately to respiratory and circulatory failure .
C0007226
cardiovascular
C0039231
tachycardia