chronic administration ( 10 mg/kg once daily for 14 or 21 days ) of imipramine or in vitro exposure ( 100 microm , 60 min ) to the antidepressant significantly reduced the ability of uk-14,304 , an alpha 2-adrenoceptor agonist , to inhibit forskolin-stimulated camp accumulation in cerebral cortical slices .
C0020934
imipramine
C0003289
antidepressant