originally identified as the hypothalamic growth hormone release-inhibiting factor , somatostatin has subsequently been shown to be extensively and selectively distributed throughout the central nervous system , to alter neuron excitability , to regulate and be regulated by the activity of classical neurotransmitters and neuropeptides , to exert a number of direct behavioral actions , and to display neuropsychiatric disorder-related alterations .
C0020663
hypothalamic
C0037659
somatostatin