no evident relationship was observed between the threshold of response to tdi and the pattern of positive response to the lower tdi concentration ( immediate in 5 , late in 8 and dual in 7 subjects ) or other clinical features ( duration of asthmatic symptoms , smoking habits , cessation of work , nonspecific bronchial hyperresponsiveness to methacholine ) ;
C0085129
bronchial hyperresponsiveness
C0600370
methacholine