to determine if il-2-induced fever is mediated indirectly through the generation of pyrogenic cytokines , culture supernatants from il-2-stimulated human peripheral blood mononuclear cells were screened for the presence of pyrogens by direct injection into rabbits and by measuring the amounts of il-1 alpha , il-1 beta , and tnf alpha by specific radioimmunoassays ( ria ) .
C0086418
human
C0021753
il-1 beta