ternary complex formation of thymidylate synthase ( 5,10-methylenetetrahydrofolated : dump c-methyltransferase , ec 2.1.1.45 ) , 5-fluorodeoxyuridylate ( fdump ) , and poly ( gamma-glutamyl ) conjugates of pteroate and methotrexate ( mtx ) has been examined as a basis for the sequence-dependent synergism of the 5-fluorouracil-mtx combination in inhibiting viability of l1210 murine tumor cells .
C0025677
methotrexate
C0280603
fluorouracil-mtx