efforts to identify novel compounds capable of blocking the steroid 5 alpha-reductase ( sr ) catalyzed conversion of testosterone ( t ) to 5 alpha-dihydrotestosterone have resulted in the development of 17 beta-substituted-3-androstene-3-carboxylic acids as potent inhibitors of the rat prostatic enzyme .
C0039602
steroid 5
C0033572
prostatic