dna damage ( putatively strand breaks ) from ionizing radiation inhibits the ability of intercalating dyes to induce right-handed supercoils in the dna loops of hela nucleoids [ cook and brazelle , j. cell sci . 22 , 287-302 ( 1976 ) ; roti roti and wright , cytometry 8 , 461-467 ( 1987 ) ] while heat-induced changes in the nuclear matrix enhance this ability [ roti roti and painter , radiat . res . 89 , 166-175 ( 1982 ) ] .
C0007634
cell
C0028581
nuclear matrix