the results of the studies support the hypothesis discussed fully in the manuscript that a partial defect in mitochondrial oxidative metabolism in achondroplastic subjects is expressed specifically in the growth plates of the long bones because this tissue has the lowest oxygen tension of any bodily organ undergoing active proliferation , thus leading to the achondroplastic phenotype in humans and the ac/ac rabbit .
C0026237
mitochondrial
C0282636
oxidative