the specific odc inhibitor , alpha-difluoromethylornithine was given as a 3 % oral solution ( 5.4 g/kg x day intake ) to hepatectomized rats as well as sham-operated controls . alpha-difluoromethylornithine had no effect other than inhibition of the low basal levels of odc in sham-operated rats , but it markedly inhibited increases in odc by 85 % in hepatectomized rats . alpha-difluoromethylornithine reduced hepatic deoxyribonucleic acid synthesis by 61 % , protein synthesis by 46 % , and liver weight increased by 83 % , showing that alpha-difluoromethylornithine inhibition of odc inhibits liver regeneration .
C0002260
alpha-difluoromethylornithine
C0029282
odc