the substitution of an hydroxyl group at position 3 and of two atoms of chlorine with fluorine in the acyl side-chain improves remarkably the antibacterial activity of the compound against strains resistant to chloramphenicol and thiamphenicol because of the production of acetyltransferases , but not against strains resistant because of non-enzymatic mechanisms of resistance .
C0279516
antibacterial
C0008168
chloramphenicol