when pain production was measured as an increase in reflex hypertensive response of the lightly anesthetized dogs after intrasplenic injection of bradykinin , the response was dependent to the doses ( 0.3-5 nmol ) of bradykinin and that by the small doses ( 0.1-1 nmol ) was blocked by intrasplenic infusion of indomethacin ( 0.54 mumol/min ) .
C0030193
pain
C0021246
indomethacin