areas for study include : roles of cholinergic mechanisms in mediating effects of stress and cholinergic mechanisms linking the pathophysiologies of affective and panic disorders , use of pharmacologic agents to produce cholinergic system supersensitivity in modeling biologic aspects of affective illness , use of multigenerational intrapedigree studies of cholinergic markers associated with affective disease , research into the neurobiology of lithium and ect as they pertain to muscarinic cholinergic mechanisms , study of the interrelationship of sodium , calcium and lithium ion metabolism and their relationship to cholinergic-monoaminergic interaction , the development of brain imaging strategies and techniques , e.g. , positron emission tomography ( pet ) , to measure changes in cholinergic receptor density and affinity as a function of clinical state , identification and validation of a peripheral model of the central muscarinic receptor , study of the pharmacology of abusable substances and its relationship to mechanisms regulating mood , affect , psychomotor function and other variables related to the affective disorders , and development of in vitro and in vivo models useful in studying the physiology and biochemistry of the interaction of cholinergic and monoaminergic neurons .
C1254351
pharmacologic agents
C0439861
substances