when the sum of the concentrations of diazepam and its active metabolites was plotted against time , the curve could be fitted by an open 2-compartment model , so that one of the apparent 3 compartments in the distribution of diazepam must be assumed to represent first pass demethylation to desmethyldiazepam .
C0012010
diazepam
C0011279
desmethyldiazepam