immunological studies of the disease also reveal other evidences of polyclonal b-lymphocyte activation : hypergammaglobulinemia , high levels of beta-2-microglobulin and circulating immune complexes , presence of various autoantibodies ( anti-collagen , antilymphocyte and , in some instances , anti-nuclear antibodies ) .
C0004358
autoantibodies
C0003243
anti-nuclear antibodies