urinary excretion patterns in volunteers and rheumatoid arthritis patients revealed that sulfate conjugation of diflunisal is a minor metabolic pathway after single 500-mg dose administration ( less than 10 % of the dose ) , whereas it becomes a major pathway ( 21.3-44.3 % of the dose ) following multiple doses ( 500 mg b.i.d . ) .
C0003873
rheumatoid arthritis
C0012228
diflunisal