the synthesis and structure-activity relationships of 7- [ ( z ) -2- ( 2-aminothiazol-4-yl ) -2-hydroxyiminoacetamido ] -3- [ ( z ) -1- propenyl ] -3-cephem-4-carboxylic acid ( bmy-28232 ) , its 3-alkenyl analogs ( 6 and 7 ) and o-substituted derivatives of the oxyimino moiety ( 10 ) are described , as well as the oral pharmacokinetics and in vivo activities of the 1-acetoxyethyl ester of bmy-28232 ( bmy-28271 ) and its analogous esters ( 11 ) .
C0007066
carboxylic acid
C0014898
esters