several points are particularly relevant to an understanding of the effects of clonidine in the brain : clonidine appears to act preferentially at alpha-2 adrenergic receptors and , in systemic doses of less than 50-100 microgram/kg , to exert its effects at autoreceptors , which initially decrease noradrenergic neuronal firing rates , ne release , and ne turnover .
C0162340
understanding
C0006104
brain