in the presence of adenine nucleotides and physiological mg2+ concentrations ( approximately 1.0 mm ) , channel activation by doxorubicin and daunorubicin exhibits a sharp dependence on submicromolar ca2+ which is accompanied by a selective , dose-dependent increase in the apparent affinity of the ryanodine binding sites for ca2+ , in a manner similar to that previously reported with caffeine .
C0013089
doxorubicin
C0011015
daunorubicin