these findings support the hypothesis that lithium 's therapeutic mode of action in manic-depressive psychosis is mediated by the combined down-regulation of both principal second messenger systems , inositol phosphates and cyclic adenosine monophosphate , by reducing the activity of phosphatidylinositol-specific phospholipase c and adenylate cyclase .
C0023870
lithium 's
C0005586
manic-depressive psychosis