the substantial rates of anp secretion which persisted in cells rendered noncontracting either by inhibiting ca2+ influx via reduction of external [ ca2+ ] to less than 10 ( -7 ) m or by inhibiting sarcoplasmic reticulum ca2+ release with 100 microm ryanodine were significantly slowed by 25 microm forskolin , but forskolin sensitivity was lost by cells exposed simultaneously to external ca2+ concentration of less than 10 ( -7 ) m and 100 microm ryanodine .
C0036226
sarcoplasmic reticulum
C0007634
cells