in the present study , we show that inactive thrombin-derived tcu-pa ( specific activity 1000 iu/mg ) can be converted with plasmin to active two-chain urokinase-type plasminogen activator ( specific activity 43,000 iu/mg ) by hydrolysis of the lys-158 -- ile-159 peptide bond .
C0042071
urokinase-type plasminogen activator
C0020291
hydrolysis