since r-ifn-gamma also induced hla-dr expression in keratinocytes and mecs , these in vitro data suggest that r-ifn-gamma may play an important role in the immunobiology of diverse skin diseases such as graft vs host disease , lichen planus , and other inflammatory dermatoses , because the keratinocytes express hla-dr and the predominant t-cell subset in the epidermis is leu 2 + ( over the leu 3 + t cell ) in all of these conditions .
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