a hypothesis is proposed to explain the inhibitory effect of verapamil on the development of atheroma formation in cholesterol-fed rabbits : assuming that macrophages play an active role in cholesteryl ester removal from atheroma , verapamil , which reduces lysosomal cholesteryl ester hydrolysis in macrophages , would permit the lipid-laden macrophage to remove more cholesteryl ester per cell from the arterial wall .
C0008377
cholesterol
C0008387
cholesteryl ester