to investigate the relationship between the effects of lidocaine on excitation patterns and its effects on the incidence of arrhythmias , the left anterior descending coronary artery was occluded for 6-min periods separated by 30 min of reperfusion , under control conditions and after injection of lidocaine , at a dose of either 2.5 , 5.0 , or 10.0 mg/kg i.v. , in 29 open-chest anesthetized pigs .
C0023660
lidocaine
C0003811
arrhythmias