morphometric analysis of the subendothelium from enzyme-treated and -untreated tissues showed that , whereas plasmin , thrombin and heparitinase each caused a dramatic reduction of the large proteoglycan granules of the extracellular matrix , only exposure to heparitinase and thrombin caused a reduction in the small proteoglycans which populate the basement membrane of smooth muscle cells .
C0015350
extracellular matrix
C0033692
proteoglycans