between may 1981 and january 1986 , 130 consecutive patients with advanced untreated head and neck squamous cell cancer ( hnscc ) received neoadjuvant chemotherapy ( nac ) with two or three courses of the cabo combination ( methotrexate 40 mg/m2 intravenously ( iv ) on days 1 and 15 ; cddp 50 mg/m2 iv on day 4 ; bleomycin 10 mg iv on days 1 , 8 , and 15 ; and vincristine 2 mg iv on days 1 , 8 , and 15 every 3 weeks ) prior to surgery and/or radiotherapy .
C0078397
cabo
C0008838
cddp