single-step mutational frequencies were low ( generally less than or equal to 10 ( -7 ] for cefoxitin , doxycycline , erythromycin , and sulfamethoxazole and relatively high ( 10 ( -4 ) to 10 ( -7 ] for kanamycin and amikacin .
C0022487
kanamycin
C0002499
amikacin