an alpha-santonin-derived cyclic peroxide ( 7 ) related to qinghaosu ( 1 ) has been synthesized and tested for antimalarial activity in vitro against the chloroquine-resistant ( smith ) isolates of plasmodium falciparum as well as in vivo against plasmodium berghei in mice and was found to be devoid of activity .
C0003374
antimalarial
C0008269
chloroquine