after 1 month of continuous therapy , captopril increased creatinine clearance from 71 to 84 ml/min/1.73 ( 2 ) ( p less than .05 ) , increased the water load excreted in 5 hr from 50 % to 71 % ( p less than .005 ) , and increased 5 hr sodium excreted from 6.8 to 14.7 meq ( p less than .005 ) , captopril also caused a decrease in plasma norepinephrine from 568 to 448 pg/ml ( p less than .005 ) , in plasma epinephrine from 94 to 73 pg/ml ( p less than .05 ) , and in plasma aldosterone from 57 to 28 ng/dl ( p less than .005 ) , without changing plasma vasopressin .
C0028351
norepinephrine
C0014563
epinephrine