the protein synthesis machinery of sulfolobus solfataricus , a thermoacidophilic archaebacterium , is insensitive to most of the known antibiotics that interfere with elongation . alpha-sarcin , a cytotoxic protein , inhibits protein synthesis on eukaryotic systems by cleaving a specific sequence of the large rrna . alpha-sarcin is capable of inhibiting protein synthesis on s. solfataricus producing a fragment under conditions similar to those which produce it in yeast ribosomes .
C0035701
rrna
C0035553
ribosomes