five beta-blockers ( propranolol , metoprolol , oxprenolol , pindolol , and sotalol ) were tested for their in vivo dna-damaging activity by two different techniques : alkaline denaturation of dna followed by hydroxylapatite chromatography , and a new viscometric method markedly more sensitive in detecting dna fragmentation .
C0012854
dna
C0000702
a