in order to elucidate the mechanisms underlying the differences in cytochrome p-450 function we have studied the 1'-hydroxylation of the prototype drug bufuralol in human liver microsomes of individuals phenotyped in vivo as extensive metabolizers ( em , n = 10 ) , poor metabolizers ( pm , n = 5 ) and in subjects with an intermediate rate of metabolism ( im , n = 4 ) .
C0010762
cytochrome
C0025519
metabolism