female lewis rats ( approximately 170 g ) received an i.v . infusion of theophylline ( as aminophylline ) at one of three different rates ( 1.03-5.1 mg/min/rat ) until the animals exhibited a maximal seizure ( which occurred after 11 +/- 1 to 42 +/- 3 min of infusion ) .
C0039771
theophylline
C0036572
seizure