physicians who did not enter all eligible patients offered the following explanations : ( 1 ) concern that the doctor-patient relationship would be affected by a randomized clinical trial ( 73 per cent ) , ( 2 ) difficulty with informed consent ( 38 per cent ) , ( 3 ) dislike of open discussions involving uncertainty ( 22 per cent ) , ( 4 ) perceived conflict between the roles of scientist and clinician ( 18 per cent ) , ( 5 ) practical difficulties in following procedures ( 9 per cent ) , and ( 6 ) feelings of personal responsibility if the treatments were found to be unequal ( 8 per cent ) .
C0184661
procedures
C0087111
treatments