initial studies of antibody recognition of ia molecules using the ia mutant mouse strain bm12 suggested that two anti-ia monoclonal antibodies ( mabs ) , 25-9-17 and 34-5-3 , share several features : ( 1 ) indistinguishable serologic specificity including a lack of reactivity with iabm12 , ( 2 ) binding of the same spatial epitope ( cluster ) , and ( 3 ) definition of a cross-reactive idiotype ( cri ) as defined by xenogeneic antisera .
C0003316
epitope
C0021013
idiotype