in a double-blind randomized comparative multicenter trial , consisting of 29 patients with acne vulgaris who were unable to tolerate daily applications of retinoic acid , the retinoic acid derivative ro 11 -- 1430 ( 0.1 % vanishing cream ) was compared in a 6 -- 8 weeks topical treatment with vanishing cream alone ( placebo ) .
C0001144
acne vulgaris
C0040845
retinoic acid