to assess pharmacokinetic and neurochemical aspects of tolerance , lorazepam ( lrz ) was administered chronically to mice via implantable osmotic pumps and rotarod ataxia , plasma and brain lrz concentrations , benzodiazepine receptor binding in vivo and in vitro , chloride channel binding and muscimol-stimulated chloride uptake were examined in various brain regions over a 14-day period .
C0006104
brain
C0086045
concentrations