imp dehydrogenase ( ec 1.1.1.205 ) , the rate-limiting enzyme of de novo gtp biosynthesis and a promising target for cancer chemotherapy , was purified 4860-fold to homogeneity from rat hepatoma 3924a by a method including affinity chromatography in which imp is bound to epoxy-activated sepharose 6b .
C0021088
imp dehydrogenase
C0030016
ec 1