at present , the most widely accepted theory to explain the arteriolar lesions , is that they result from a sickle-cell thrombosis of the vasa-vasorum , but , we think it is not the only valid hypothesis and we think that other phenomena may be involved with a genetic factor ( patients with connective tissue disorders may have a particular genotype ) , and with infectious or autoimmune or coagulation disorders , the latter being frequently observed in this disease .
C0009782
connective tissue disorders
C0012634
disease