our data do not clarify the question of target concentration or minimal exposure time above which permanent closure may occur , but the group of infants who had permanent pda closure after only one dose ( 8/17 ) had a significantly higher plasma indomethacin concentration time integral than the group ( 9/17 ) who needed more than one dose ( p < 0.01 ) .
C0013274
pda
C0021246
indomethacin