since effects of insulin on pyruvate dehydrogenase phosphatase activity are not evident in mitochondrial extracts , it is concluded that insulin may act by altering some high-mr component which interacts with the pyruvate dehydrogenase system within intact or permeabilized mitochondria , but not when the mitochondrial membranes are disrupted .
C0026237
mitochondria
C0596952
mitochondrial membranes