we have investigated the effects of the tumor-promoting phorbol diester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , on rabbit synovial fibroblasts , and found that this agent induced a major switch in gene expression in these cells that was marked by the specific induction of the neutral proteinase , collagenase , and was always accompanied by alterations in cell morphology .
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fibroblasts
C0007634
cells