besides the inhibition of nucleic acid metabolism reactions , characteristic of dna-intercalators , and disruption the mitochondrial atp synthesis , also characteristic of organic heterocyclic cationic molecules of dna-intercalators , sanguinarine can modify the thiol groups of enzymes including sh-sensitive membrane-bound na+ , k ( + ) -atpase of cerebral cortex and ca2 ( + ) -atpase of skeletal muscle sarcoplasmic reticulum fragments .
C0028606
nucleic acid
C0012854
molecules