km parameters determined for amt ( km = 4.3 microm ) were similar to those determined for several reduced folates ( tetrahydrofolic acid , dihydrofolic acid , and folinic acid ; km = 3-7 microm ) , while significantly higher km values were observed for methotrexate ( mtx ) and 5-methyltetrahydrofolic acid ( km = 50-60 microm ) and for folic acid ( km = 100 microm ) .
C0025677
methotrexate
C0016410
folic acid