since monoclonal antibody specific for the egf receptor abolished both egf binding to its receptor and tyrosine phosphorylation of the c-erbb-2 gene product , we have concluded that activation of egf receptor tyrosine kinase activity upon egf binding leads to the phosphorylation of the c-erbb-2 gene product on its tyrosine residues .
C1519726
tyrosine phosphorylation
C0033681
tyrosine kinase