based on ( a ) the peak levels of tnf observed in serum , 2.5 x 10 ( 3 ) u/ml , ( b ) the specific activity of purified rabbit macrophage-derived tnf , 1 x 10 ( 8 ) u/mg , and ( c ) the biphasic disappearance of intravenously injected purified tnf ( t1/2 = 0.5 min , 11 min ) we constructed a kinetic model showing that at least 130 micrograms of tnf ( 1.3 x 10 ( 7 ) u ) was released into plasma 30-200 min postinjection of lps .
C0229671
serum
C0032105
plasma