these platelet aggregation inhibiting effects in combination with increases in fibrinolytic activity under pentoxifylline administration are suggested to be the main determinants of the compound 's antithrombotic properties as evident from investigations in different animal models of thrombosis : intravascular thrombus formation upon stimulation by both iontophoretically introduced adp or laser injury of endothelium in the hamster cheek pouch and in the rat mesentery , respectively , was significantly reduced under pentoxifylline .
C0040053
thrombosis
C0030899
pentoxifylline