accumulation of datp derived from 2'-deoxyadenosine ( dado ) , causing inhibition of ribonucleotide reductase and depletion of the other deoxynucleotide substrates required for dna synthesis , has been suggested as the cause of the lymphopenia and immune defect in inheritable deficiency of adenosine deaminase ( adenosine aminohydrolase , ec 3.5.4.4 ) .
C0035547
ribonucleotide reductase
C0598312
dna synthesis