chronic treatment of 3t3-c2 fibroblasts with insulin causes the slow ( t1/2 = 3-4 h ) down-regulation of cellular insulin receptor to a new steady state level by accelerating receptor decay ( knutson , v.p. , ronnett , g.v. , and lane , m.d . ( 1982 ) proc . natl . acad . sci . u.s.a. 79 , 2822-2826 ) .
C0016030
fibroblasts
C0007634
cellular