in the present study , we found that in isolated perfused rat heart , administration of phorbol esters 4 beta-phorbol 12,13-dibutyrate ( pdbu ) and 12-0-tetradecanoylphorbol 13-acetate ( tpa ) , which are specific activators of protein kinase c , produced marked dose-dependent negative changes in inotropy and chronotropy .
C0031586
phorbol esters
C0039654
tetradecanoylphorbol