it is concluded that enhanced 5-ht neurotransmission which develops during chronic treatment with imipramine or lithium seems tob e related to the down-regulation of postsynaptic 5-ht1a receptors in addition to postsynaptic 5-ht2 receptors , which may also have an important role in the antidepressant effects of these drugs .
C0020934
imipramine
C0003289
antidepressant