two benzofuran-2-ethanolamines ro 03-5255 ( 1- ( 5-acetylamino-benzofuran-2-yl ) -1-hydroxy-2-isopropylaminoethane ) and ro 03-7894 ( 1- ( 5-chloracetyl aminobenzofuran-2-yl ) -1-hydroxy-2-isopropylaminoethane ) which had previously been shown to exhibit respectively competitive and irreversible beta-adrenoceptor antagonism in guinea-pig isolated atria , were compared in vivo using isoprenaline-induced tachycardia of anaesthetized guinea-pigs and heart rate and contractility ( dp/dtmax ) of open-chest anaesthetized guinea-pigs and of conscious cats .
C0022245
isoprenaline
C0039231
tachycardia