between september 1976 and june 1982 , 308 patients with operable breast cancer with 1-3 involved axillary nodes were stratified according to institution , type of mastectomy , and time from surgery to protocol entry , and then randomized to receive either six or 12 months of adjuvant chemotherapy with cyclophosphamide , methotrexate , and 5-fluorouracil ( cmf ) .
C0025677
methotrexate
C0950521
cmf