as a first step in our long-range goal of defining those features of the igf-i and igf-ii molecules that confer enhanced mitogenic activity and reactivity with these mitogenic type i igf receptors , we have prepared two hybrid insulin-igf molecules and examined their mitogenic and binding activities : ( 1 ) a27-insulin , containing an elongated 27-residue a-chain ( in which the 6-residue d-domain of igf-ii was added to the carboxy-terminus of the 21-residue a-chain of insulin ) combined with the b-chain of insulin ;
C0021665
igf-i
C0037657
igf