these results demonstrate that constitutive levels of 3-methylcholanthrene- and phenobarbital-specific cytochromes p-450 are localized predominantly in centrilobular hepatocytes of murine livers , and induction of the hemoproteins is manifested to the greatest extent in periportal hepatocytes , resulting in a more uniform distribution throughout the hepatic lobule .
C0023884
livers
C0227518
hepatic lobule