the predicted mean steady-state concentrations of d-f and elimination half-lives calculated from the results of a previous single dose study were similar to those measured at steady state in this study , confirming the lack of effect of the drug on hepatic microsomal enzymes and on kinetics after repeated dosing . d-nf concentrations were approximately half those of the parent drug and the half-life was almost twice as long .
C0022702
kinetics
C0018517
half-life