enzymatic digestions of vitamin a containing nucleosomes with proteinase k , phospholipase c , and phospholipase a2 support a model where the final binding of retinol to chromatin is mediated by a lipoprotein : the recognition of the binding sites on dna being dictated by the proteic component while the hydrophobic retinol is solubilized in the fatty acid moiety .
C0028623
nucleosomes
C0008546
chromatin