within 4 h after addition to monolayer cultures , 1.0 microm taxol induces a lateral aggregation of microtubules which , by 12 to 24 h of treatment , results in the appearance of dense bundles of tightly-packed microtubules located near the centrosome , close to the outer nuclear envelope , and at peripheral cytoplasmic sites .
C0242608
centrosome
C0010834
cytoplasmic