these data indicate that the c-2 and c-16 oxidations of estradiol take place in cultured avian hepatocytes and that the extent of metabolism at these positions on the hormone molecule can be altered by chemicals , such as drugs and polycyclic aromatic hydrocarbons , which induce distinctive species of cytochrome p-450 in the liver .
C0025519
metabolism
C0010762
cytochrome p-450