when given to rats , orotic acid , a precursor of pyrimidine nucleotides , results in an imbalance in nucleotide pools ( an increase in uridine nucleotides and a decrease in inosine/adenine nucleotides ) , alterations in both dna and membranes , and promotion of carcinogenesis in the liver initiated by chemical carcinogens .
C0034288
pyrimidine nucleotides
C0028630
nucleotide