to investigate whether dna methylation plays a role in expression of dr genes in leukemia , we analyzed methylation patterns of the dr-alpha and d/dr-beta genes in the dr antigen-positive and -negative b-cell lines , in normal adults and in chronic lymphocytic leukemia ( cll ) patients using southern blot hybridization of dna digested with msp i and hpa ii .
C0004561
b-cell
C0023434
chronic lymphocytic leukemia