in rat ventral prostate ( cytosolic and nuclear fractions ) and cytosol from human prostatic carcinoma , rat uterus and mouse shionogi mammary carcinoma , the ki values ranged from 0.1 to 0.47 , 0.6 to 2.7 , 62 to 205 and 1450 to 7550 nm for dihydrotestosterone , t , flutamide-oh and flutamide , respectively . since the ability of flutamide-oh to inhibit the uptake of [ 3h ] t in intact adenohypophysial cells and to compete for binding to the adenohypophysial androgen receptor shows almost identical values at approximately 1 % of the potency of t itself , it is most likely that the antiandrogen activity of flutamide-oh can be completely explained by the ability of the pure antiandrogen to displace androgen from their specific receptor in target tissues .
C1706715
adenohypophysial cells
C0032008
adenohypophysial