this commercially available valvular bioprosthesis is characterized by 1 ) loss of endothelium from both surfaces of the leaflets , 2 ) modification in the organization of the fibrous connective tissue of the leaflet , and 3 ) a reduction in the macromolecular complexes ( proteoglycan ) of the extracellular matrix .
C0033692
proteoglycan
C0015350
extracellular matrix