coumermycin , novobiocin , nalidixic acid , and oxolinic acid are known to be inhibitors of escherichia coli gyrase , to inhibit e. coli dna replication , to abolish colicin e1 replication , and to depress the supercoiling of phage lambda dna , the last two via inhibition of the dna gyrase .
C0598312
replication
C0012854
dna