to determine the biochemical mechanism of the increased cytostatic action of these compounds toward tk- cell lines , bvdu and ivdu were further evaluated for their inhibitory effects on pyrimidine nucleotide metabolism , in particular thymidylate synthetase activity , their incorporation into dna and into trichloroacetic acid ( tca ) -insoluble material , and their effects on dna , rna and protein synthesis in both tk+ and tk- cells .
C0035668
rna
C0597295
protein synthesis