intravenous injection of 6-iodo-amiloride , a sodium channel blocker and vasodilator , produces an immediate and sustained decrease in blood pressure in two genetic models of hypertension characterized by increased permeability of the vascular smooth muscle cell membrane to sodium ( okamoto spontaneously hypertensive rat , dahl salt sensitive rat ) , whereas it produces only a transient fall in arterial pressure in two renal models of hypertension having normal sodium permeability in vascular smooth muscle cells ( reduced renal mass-saline rat , one-kidney , one clip rat ) .
C0002502
amiloride
C0020538
hypertension