the present results , taken together with previous observations that the wearing-off phenomenon responds promptly to plasma levodopa stabilization while on-off fluctuations tend to diminish over several days , suggest that postsynaptic modifications , presumably at the receptor level , serve as the major determinant for the increasing difficulty with optimal dose adjustment and the motor fluctuations , especially of the on-off type , which complicate levodopa therapy of patients with advanced parkinson 's disease .
C0023570
levodopa
C0030567
parkinson 's disease