in the anesthetized dogs , using the short-lived positron emitting isotope of carbon ( 11c ) either in the form of molecular co2 or as hco3- injected intraarterially it was demonstrated that there is first pass uptake of 16 % of hco3- from blood into brain and 86 % uptake of molecular co2 , thus indicating that the brain-blood barrier is permeable to hco3- , but that hco3- content in the cns is regulated as a function of dissociation of strong ions such as cl- and na+ .
C0005854
brain-blood
C3714787
cns