since upon i.c.v . infusion the dose needed for a blood pressure lowering effect is the same as that needed for a s.c. infusion , in spite of 100-fold higher brain-levels , it is concluded that the antihypertensive effect of propranolol in spontaneously hypertensive rats is not caused by an action of the drug in the central nervous system .
C0020649
blood pressure lowering
C0033497
propranolol