a study of the biochemical effects of 1,3-bis ( 2-chloroethyl ) -1-nitrosourea ( bcnu ) on the growth of human melanoma cells ( twi ) revealed that this antitumor agent inhibits : ( i ) the synthesis of ribosomal rna , ( ii ) the synthesis of cellular proteins of molecular weight greater than 49 kda and ( iii ) the synthesis and release of extracellular proteins to the growth medium .
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growth of
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cellular