however , calculation of the amounts of haemoglobin synthesized per cell suggests that in the hpfh/beta-thalassaemia heterozygote , the beta- and agamma-chain genes in cis to the hpfh determinant are unable to compensate for the deficiency of chains imposed by the beta-thalassaemia gene in trans and that the increased synthesis of hb f is directed by the gamma-chain genes located on the beta-thalassaemia chromosome .
C0019046
haemoglobin
C0015936
hb f