in order to assess whether the spleen is the major site of replication of lactate dehydrogenase-elevating virus ( ldv ) in mice during the acute phase of infection , ldv replication in the spleen was measured by electron microscopy and fluorescent antibody staining of tissue sections and northern hybridization of total spleen rna with an ldv-specific cdna probe , and the effect of splenectomy on ldv replication was determined .
C0037993
spleen
C0037995
splenectomy