the relationship between p-xylene 's effects on microsomal membranes , cytochrome p-450 , and benzo [ a ] pyrene ( bap ) metabolism was studied . p-xylene ( 1 g/kg , ip , 1 h ) inhibited 3-hydroxy bap ( 3-oh ) formation and decreased arylhydrocarbon hydroxylase ( ahh ) activity approximately 40 % in rat lung microsomes .
C0010762
cytochrome
C0025519
metabolism