direct immunofluorescent staining with fluorescein isothiocyanate conjugated goat anti-human beta 2-microglobulin ( beta 2m ) was used to determine the localization of beta 2m in kidney tissue , obtained by biopsies or nephrectomies for various renal diseases . beta 2m was found in the renal tubular epithelial cell cytoplasm and occasionally in the tubular basement membranes in 48 out of 79 pathologic specimens tested , but not in 3 normals . beta 2m was seen in the tubular cells in all cases of primary tubulointerstitial disease and in all cases with secondary tubular damage associated with glomerular disease or systemic disease .
C0022658
renal diseases
C0027707
tubulointerstitial disease