a comparison of the spectra of normal human adult hemoglobin with those of mutant hemoglobins chesapeake ( fg4alpha92 arg yields leu ) , titusville ( g1alpha94 asp yields asn ) , m milwaukee ( e11beta67 val yields glu ) , malmo ( fg4beta97 his yields gln ) , kempsey ( g1beta99 asp yields asn ) , yakima ( g1beta99 asp yields his ) , and new york ( g15beta113 val yields glu ) , as well as with those of chemically modified hemoglobins des-arg ( alpha141 ) , des-his ( beta146 ) , nes ( on cys-beta93 ) -des-arg ( alpha141 ) , and spin-labeled hemoglobin [ cys-beta93 reacted with n- ( 1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl ) iodoacetamide ] , suggests that the proton in the important hydrogen bond between the tyrosine at c7alpha42 and the aspartic acid at g1beta99 , which anchors the alpha1beta2 subunits of deoxyhemoglobin ( a characteristic feature of the deoxy quaternary structure ) , is responsible for the resonance at -9.4 ppm from water at 27 degrees .
C0019016
a
C0019046
hemoglobin