among the enzymes analyzed , fetal-type liver enzymes ( low-km hexokinase , glucose 6-phosphate dehydrogenase , and pyruvate kinase-m2 ) showed increased activities , and adult-type liver enzymes [ glucose 6-phosphatase , fructose 1,6-bisphosphatase , high-km hexokinase ( or glucokinase ) , and pyruvate kinase-l ] showed decreased activities , resulting in undifferentiated enzyme patterns not only in fetal livers and hepatocellular carcinomas but also in livers of acute and chronic hepatitis and liver cirrhosis with or without tumors .
C0023884
livers
C0019189
chronic hepatitis