using the ratios of substrate/product , i.e. , r1 = pge1/19-hydroxy-pge1 and r2 = pge2/19-hydroxy-pge2 , as indicators of prostaglandin 19-hydroxylase capacity , a bimodal distribution of r values was found : nine men ( 23 % ) were slow hydroxylators ( r1 greater than 0.45 and r2 greater than 0.45 ) , while the remaining men were rapid hydroxylators ( both r1 and r2 less than 0.45 ) .
C0002335
pge1
C0033554
prostaglandin