because of the lack of influence of the frequency of fluoride supplementation on caries inhibition and the lack of correlation between caries reductions and f-m and s-m it was concluded from the caries tests that in the rat the interference of fluoride with the bacterial metabolism through its continous presence at the plaque-enamel interface rather than the reduction of enamel solubility and the promotion of enamel remineralization seems to be its most important cariostatic mechanism .
C0011334
caries
C0016327
fluoride