the nicotine-induced contraction was insensitive to bunazosin and yohimbine ( alpha 1- and alpha 2-adrenoceptor antagonists , respectively ) , and exogenously applied noradrenaline did not cause a contraction even in the presence of blockade of noradrenaline uptake mechanisms with desipramine and normetanephrine and of beta-adrenoceptors with propranolol , suggesting a non-adrenergic nature of the sympathomimetic effect of nicotine in this tissue .
C0028351
noradrenaline
C0028385
normetanephrine