but with subacute treatment , tolerance to the effect rapidly developed.3 brain hexobarbitone concentration upon awakening was unchanged by either acute or subacute cbd treatment , which suggests that neither the prolongation of sleeping time nor the tolerance is the result of a change in sensitivity of the central nervous system to the barbiturate.4 acute cbd treatment increased the half-time of hexobarbitone in the brain , which returned toward normal with the development of tolerance.5 acutely , cbd caused a 30 % decrease in hepatic cytochrome p-450 level ;
C0086045
concentration
C0006104
brain