although castration levels of serum androgens are consistently achieved after 2-3 weeks of treatment with luteinizing hormone-releasing hormone ( lhrh ) agonists , the administration of these peptides alone in adult men is always accompanied by a transient increase in plasma testosterone and dihydrotestosterone levels , which lasts for 5-15 days at the beginning of treatment and is accompanied by disease flare-up in some cases , thus seriously limiting the acceptability of this otherwise efficient and well-tolerated treatment .
C0229671
serum
C0032105
plasma