in addition , an examination of the relative hne levels in brain , retina , retinal pigment epithelium ( rpe ) , and kidney of an affected dog compared with a control animal also showed abnormal levels of hne , particularly in brain ( +168 % ) and in the rpe ( +135 % ) , the two organs exhibiting the most severe pathologic damage unique to these disorders .
C0035298
retina
C0035322
rpe