the observations of a family in which the mother has ganglioneuroma and both daughters have developed neuroblastoma , of a child who suffered from both neuroblastoma and neurofibromatosis von recklinghausen , and of a significantly higher frequency of infants with signs of multicentric tumours in the offspring of mothers aged under 20 and over 34 years of age , is consistent with the two-hit theory of knudson et al .
C0008059
child
C0021270
infants