at least one component of opiate reward is dependent on a dopaminergic system : ( a ) electrophysiological and neurochemical indices suggest that opiates activate ventral tegmental dopaminergic neurons , ( b ) ventral tegmental opiate infusions are behaviorally activating producing contralateral rotation that is blocked by neuroleptics , ( c ) reward from heroin is blocked by neuroleptics , and ( d ) reward from heroin is attenuated by dopamine-depleting lesions of the ventral tegmental system .
C0282151
dopaminergic
C0013030
dopamine