the treatment of b16 melanoma bearing mice with the maximal tolerated dose of dx ( 12 mg kg-1 i.v . ) and of vrp ( 25 mg kg-1 i.p . ) selected a line ( b16-dx . vrp ) completely resistant to dx after 17 transplants , while treatment with dx alone selected a dx resistant line after 27 transplants .
C0042523
vrp
C0281009
dx