previously untreated patients with multiple myeloma were entered on a randomized clinical trial to determine whether the use of alternating combination chemotherapy , including vincristine , doxorubicin , alkylating agents , and prednisone ( 160 patients ) was more effective than conventional chemotherapy with melphalan and prednisone ( 77 patients ) , and whether the addition of the immunomodulating agent levamisole to maintenance chemotherapy enhanced the survival of patients achieving remission .
C0026764
multiple myeloma
C0025241
melphalan