most pathologic studies of liver disease in sickle cell anemia and its variants were performed retrospectively on autopsy specimens , and , because of the prominent histologic features of intrasinusoidal sickling and kupffer cell erythrophagocytosis , hepatic dysfunction was attributed to the intrahepatic sickling of erythrocytes in this hemoglobinopathy .
C0002895
sickle cell anemia
C0019045
hemoglobinopathy