it is proposed that , although the cytochrome p-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei , the metabolism of 1,2-dichloroethane and 1,1,2,2-tetrachloroethane by nuclear cytochrome p-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds .
C0010762
cytochrome p-450
C0025519
metabolism