two out of three normal eyes tested with frequent instillation of 30 microliters of drops of 0.5 % bupranolol , a beta 1 + beta 2 blocking drug with some intrinsic sympathomimetic and local anesthetic activity , showed a miotic effect of the order of a 25 % reduction of pupil area , as estimated by an open-loop iris-videorecorder .
C0034121
pupil
C0022077
iris