this , in turn , could affect the biosynthesis of extracellular matrix macromolecules , as suggested , for example , by the hypothesis of rohrbach et al , based on studies of a basement membrane-producing tumor implanted in diabetic mice , which proposes that the hyperglycemia of diabetes mellitus causes a reduced synthesis of the heparan sulfate bm-1 proteoglycan with a subsequent overproduction of type iv collagen .
C0015350
extracellular matrix
C0009325
collagen