ultrastructural and cell surface studies of skin in psoriatic patients prior to and after goeckerman therapy ( crude coal tar and uvb-light ) have demonstrated significant cellular changes following this treatment : hyperactivity of melanocytes with melanosome polymorphism , increase of desmosomes , tonofilaments , keratohyaline granules , a decrease in mitochondria , keratinosomes , polysomes , dark cells and a reduction in size of nuclei and nucleoli .
C0007634
cellular
C0011703
desmosomes