our data suggest that there is no direct interference of tolbutamide with pyridine nucleotides of pancreatic islets , and that tolbutamide increases the secretory response of the beta-cell to aminophylline , 3,5-amp-dibutyrate or glucagon when insulin release due to these agents is inhibited during decrease of insular nadp and nadph , caused by 6-an .
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the
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secretory