with tolerance , the cytochrome concentration returned to normal.6 the evidence suggests that the cbd-induced prolongation of barbiturate sleeping time and the tolerance to this effect are the result of changes in the rate of drug metabolism , which are related to changes in the amount of cytochrome p-450.7 the effects of cbd on the hepatic microsomal drug-metabolizing enzyme system are different from those attributed to skf 525-a and piperonyl butoxide because the cannabinoid does not decrease cytochrome p-450 quantitatively by complex formation , it does not produce a recovery overshoot in the cytochrome concentration and , finally , it does not cause an induction of the hexobarbitone-metabolizing enzymes .
C0004745
barbiturate
C0019469
hexobarbitone