although cordycepin 5'-triphosphate ( 3'-datp ) , at low concentrations , preferentially inhibits chromatin-associated poly ( a ) synthesis in isolated nuclei , higher levels of the inhibitor prevent both rrna ( rna polymerase i activity ) and hnrna ( rna polymerase ii activity ) synthesis in vitro ( rose , k.m. , bell , l.e . and jacob , s.t . ( 1977 ) nature 267 , 178-180 ) .
C0008546
chromatin
C0007610
nuclei