in the hypothalamus , pregnanolone appears to be the final signal for its action on the lhrh neural apparatus , whereas in the corpus striatum , the steroid per se , and dependent on the modality and/or the strength of the signal can either directly or indirectly up-regulate ( stimulatory component ) or down-regulate ( inhibitory component ) the activity of striatal dopaminergic terminals .
C0020663
hypothalamus
C0023610
lhrh