while these mutant cells showed a normal ability to bind low density lipoprotein at its high affinity cell surface receptor site , to take up the bound lipoprotein through endocytosis , and to hydrolyze the protein component of the lipoprotein in lysosomes , their defective lysosomal hydrolysis of the cholesteryl ester component of the lipoprotein led to the accumulation within the cell of unhydrolyzed cholesteryl esters , the fatty acid distribution of which resembled that of plasma lipoprotein .
C0024369
lysosomes
C0007634
cell