in contrast , in higher concentrations ( 10 ( -7 ) - 10 ( -5 ) m ) , it reduced , in a dose-dependent manner , both the spontaneous release of crf from the hypothalami and the release which normally occurred in response to acetylcholine , 5-hydroxytryptamine , morphine , met-enkephalin and leu-enkephalin .
C0010132
crf
C0020663
hypothalami