when increasing doses ( 0.01 -- 10 mg/kg ) of non-labelled benzodiazepine derivatives ( flunitrazepam , clonazepam , the 3s and 3r enantiomers of 5- ( o-fluorophenyl ) -1,3-dihyrdo-1,3-dimethyl-7-nitro-2h-1,4-benzodiazepine-2-one , and chlordiazepoxide ) were injected simultaneously with [ 3h ] flunitrazepam , a dose-dependant , saturable and and stereo-specific decrease of [ 3h ] flunitrazepam concentration in the mouse hippocampus was observed .
C0005064
benzodiazepine
C0008188
chlordiazepoxide