14 patients with refractory hypertension did not respond either to captopril , an angiotensin ii converting enzyme inhibitor , combined with a diuretic , a beta-blocker and hydralazine or minoxidil , a potent vasodilator , but they did respond to the combination of captopril , minoxidil , furosemide and a beta-blocker .
C0020538
hypertension
C0016860
furosemide