in rats exposed to a simulated high altitude of 3500 m or 6000 m for 6 -- 7 weeks , myocardial necrosis was produced by ligation of the left coronary artery close to its origin , by ligation of the descending branch of the left coronary artery ( true infarcts ) , or by administration of a large dose of isoprenaline .
C0027051
myocardial necrosis
C0021308
infarcts