the brain lesions in spontaneously hypertensive stroke-prone rats ( shrsp ) are characterised by multifocal microvascular damage , breakdown of the blood-brain barrier , massive extravasation of plasma constituents and severe brain oedema , with consequent spongy and cystic tissue destruction in the cerebral cortex and basal ganglia as well as loosening of the white matter .
C0038454
stroke
C0006104
brain