gapped circular dna is constructed by annealing viral single-stranded circular dna [ ss ( c ) dna ] with a mixture of linear duplex dnas that have had their 3'-oh termini processively digested with escherichia coli exonuclease iii under conditions in which the resulting , newly generated 3'-oh termini present in the various hybrid molecules span the region of interest .
C0012925
circular dna
C0012854
dnas