10 of 20 patients with advanced myeloma treated with a simple regimen consisting of weekly low-dose cyclophosphamide ( c ; 150-300 mg/m2 ; maximum weekly dose = 500 mg ) given intravenously or orally , and alternate-day oral prednisone ( p ; 50-100 mg ) responded clinically and with a fall in serum m protein greater than 50 % or urine m protein greater than 90 % .
C0026764
myeloma
C0010583
cyclophosphamide