temperature-shift-down experiments with phie-infected cells having thermosensitive dna polymerase iii ( pol iii ( ts ) ) indicate that at 48 c the thermolabile dna polymerase iii is irreversibly inactivated and has to be synthesized de novo after the shift to 37 c , before phage dna synthesis can begin .
C0012890
dna polymerase iii
C0598312
dna synthesis