because the iso-induced increase in 45ca efflux was abolished by pretreatment of the cells with the na+-k+ pump inhibitor ouabain and by lowering extracellular na+ levels , we propose that the increased ca2+ extrusion in response to iso is coupled to increased activity of the plasmalemmal na+-k+ pump via increased na+-ca2+ exchange .
C0007634
cells
C0007603
plasmalemmal