although during this period , no ip or uterine wet weight response can be elicited by estradiol , administration of saturating levels of [ 3h ] estradiol in vivo or in vitro results in the appearance of considerable [ 3h ] estradiol in the nucleus , bound to a macromolecule sedimenting identically with that of the nuclear receptor-estradiol complex ( 5.5s ) formed in the absence of prior antiestrogen exposure .
C0007610
nucleus
C0206588
nuclear