the frequency of their appearance has been studied in normal subjects ( blood donors , aged people , vaccinated subjects , post-traumatic splenectomy ) and in patients with a neurologic disease ( multiple sclerosis ) , a neoplasic disease ( breast cancer ) and hematologic diseases ( thrombocytopenia , acute leukemia , chronic lymphatic leukemia , hodgkin disease and systemic lupus erythematosus ) .
C0012634
disease
C0018939
hematologic diseases