intra-arterial administration of nifedipine or of verapamil to anesthetized dogs by the intracerebroventricular ( icv , 1 and 10 micrograms/kg in 1 min ) , or intravertebral ( 0.1 and 1 mg/kg in 5 sec ) or intra common carotid artery ( 0.1 and 1 mg/kg in 5 sec ) produced hypotension and sinus bradycardia and slightly reduced the pressor response induced by carotid occlusion .
C0042523
verapamil
C0020649
hypotension