upon incubation in high ionic strength media this protease , normally found tightly associated with isolated calf thymus chromatin , releases the 15 cooh-terminal amino acids of histone h2a by specifically cleaving the h2a polypeptide between val114 and leu115 , yielding cleaved h2a ( ch2a ) and a free pentadecapeptide ( eickbush , t. h. , watson , d. k. , and moudrianakis , e. n. ( 1976 ) cell 9 , 785-792 ) .
C0008546
chromatin
C0007634
cell