assessing interactions with other classes of steroid hormone receptor can be used to predict possible hormonal side-effects , ( 2 ) in vitro determinations of agonist or antagonist activity , e.g . in pituitary cells ( lh response to lhrh ) or mammary tumor cells ( induction of androgen-dependent proteins ) , ( 3 ) in vivo antiandrogen assays after a single treatment ( induction of mouse kidney proteins , rat prostatic binding protein ) or after repeated treatment ( inhibition of the growth of rat accessory glands or of hamster sebaceous glands ) , to determine the active dose of the compound and possibly the absence of systemic effects by the topical route , ( 4 ) assays in animal models designed to mimic a therapeutic context e.g . for prostate cancer : inhibition of the `` '' flare-up '' '' effect of lhrh-a or of the trophic effect of perfused adrenal androgens on rat prostate , antitumoral activity in experimental cancer models .
C0033572
prostatic
C0376358
prostate cancer