the present studies used the 9l gliosarcoma model in fischer 344 rats to evaluate the increase of tumor vessel permeability by osmotic bbb opening on drug delivery to the tumor , brain adjacent to tumor ( bat ) , and brain distant to tumor using cis-diamminedichloroplatinum ( cddp ) as a chemotherapeutic agent which was water soluble and rarely permeable to bbb .
C0006118
brain
C0006104
brain