when coronary artery ligation was performed 1 h after the last oral dose ( at which time there was evidence of substantial myocardial beta 1-adrenoceptor blockade ) , there was significant reduction in the severity of early arrhythmias , but no evidence that the severity of ischaemic damage was reduced or that the intracellular cardiac action potentials were modified .
C0027061
myocardial
C0018787
cardiac