intraperitoneal administration of 9-trans-delta-tetrahydrocannabinol ( thc ) , the major psychoactive component of cannabis , in doses of 0.5 , 1.0 and 2.0 mg/kg , produced a dose-related increase in the brain concentrations of prostaglandin ( pg ) e2 and pgf2 alpha in male rats 4 h after thc administration , as assessed by radioimmunoassay .
C0006104
brain
C0086045
concentrations