a single injection of muifn ( 2 x 10 ( 6 ) to 2 x 10 ( 7 ) iu/kg of muifn ) or poly ( i ) : poly ( c ) ( 0.12-1.2 mg/kg ) caused a significant lymphocytopenia without any evidence of direct cytotoxic effects on lymphocytes in the blood or lymphoid organs , a significant decrease in the number of t cells both in the thymus and spleen along with a significant increase in the number of non-t cells in the splenic white pulp , and a differential decrease in the number of blood t-cell subsets ( `` '' suppressor/cytotoxic '' '' subset was decreased continuously whereas `` '' helper '' '' subset only transiently ) .
C0037993
spleen
C0229686
splenic white pulp