during the course of antimalarial screening , it was discovered that sulfamethoxydiazine , a long-acting sulfanilamide extensively used in genitourinary tract infections , not only was effective against plasmodium berghei infections in mice when administered alone but also was active when used in combination with chloroquine , in effect making it possible to use half as much of the latter drug as normally required to achieve the same results .
C0003374
antimalarial
C0008269
chloroquine