in order to probe key early molecular events which might be responsible for the initiation of rat pancreatic tumorigenesis by 4-hydroxyaminoquinoline 1-oxide ( 4-haqo ) , the uptake and metabolism of carcinogen and the formation and subsequent repair of dna adducts were monitored under conditions of high and low tumorigenicity , respectively in partially pancreatectomized and non-operated animals , and in the liver , a non-target organ for this carcinogen .
C1516272
metabolism
C0007090
carcinogen