in an attempt to increase the dose of delivered drug without markedly increasing toxicity , cisplatin was administered by 5-day continuous intravenous infusion at a dose of 28 mg/m2/day ( total dose 140 mg/m2 ) to 15 evaluable patients ( 5 with astrocytoma grade iii and 10 with astrocytoma grade iv ) .
C0008838
cisplatin
C0004114
astrocytoma