fibroblast cultures from two individuals with biotin-responsive organicacidemia were found to have a pleiotropic deficiency of propionyl-coa carboxylase , beta-methylcrotonyl-coa carboxylase , and pyruvate carboxylase activities after growth in biotin limited culture medium , conditions which do not affect the carboxylase activities of normal cells .
C0016030
fibroblast
C0007634
the