considered collectively , the findings that the cardioacceleration observed following intrathecal vip injection is mimicked by i.v . administration , is not reversed by blockade of nicotinic transmission of autonomic ganglia or by bilateral vagotomy , and is not blocked by lidocaine suggest that vip 's tachycardic effect does not result from a direct action on spinal mechanisms mediating autonomic control of the cardiovascular system , but occurs via diffusion to a site of action outside the central nervous system .
C0039231
tachycardic
C0007226
cardiovascular