we conclude that this fraction contains a unique hybrid proteoglycan bearing both heparan sulfate and chondroitin sulfate glycosaminoglycans because ( i ) the proteoglycan behaves as a single species by sizing , ion exchange and collagen affinity chromatography , and by isopycnic centrifugation , even in the presence of 8 m urea or 4 m guanidine hydrochloride , ( ii ) the behavior of the chondroitin sulfate in these separation techniques is affected by heparan sulfate-specific probes and vice versa , and ( iii ) proteoglycan core protein bearing both heparan sulfate and chondroitin sulfate is recognized by a single monoclonal antibody .
C0033692
proteoglycan
C1700419
proteoglycan core protein