these data demonstrate that in nephrotoxic acute renal failure , decreased prostaglandin metabolism ( i.e. , prostaglandin e2-9-ketoreductase activity ) can result in increased tissue levels of prostaglandin e2 in the absence of increased prostaglandin synthesis and suggest that alterations in prostaglandin metabolism may be an important regulator of prostaglandin activity in acute renal failure .
C0012472
prostaglandin e2
C0033554
prostaglandin