that the fructose-induced renal acidification defect involves a reduced h ( + ) secretory capacity of the proximal nephron is supported by the magnitude of the reduction in t hco ( 3 ) ( - ) ( 20-30 % ) and the simultaneous occurrence and the persistence throughout administration of fructose of impaired tubular reabsorption of phosphate , alpha amino nitrogen and uric acid.a reduced h ( + ) secretory capacity of the proximal nephron also appears operative in two unrelated children with hyperchloremic acidosis , fanconi 's syndrome , and cystinosis .
C0022646
renal
C2931187
cystinosis