although general guidelines may be formulated now to assist clinicians in constructing dosage regimens of several important drug classes ( notably the benzodiazepines and barbiturates ) in hepatic disease , it is not now possible to predict in an individual the influence of a specific hepatic disease on the disposition of a drug , with the exception that the oral availability of drugs with high hepatic extraction ratios is increased in patients with cirrhosis and protacaval shunting of blood .
C0023895
hepatic disease
C0023890
cirrhosis