the terminal accelerated phase of chronic granulocytic leukemia , for instance , in which undifferentiated blast cells replace a previously well-differentiated population , seems to represent emergence of a subline , often recognizable cytogenetically , in which an additionally altered response to growth regulation further shifts the balance between proliferation and differentiation at the stem cell level , so that undifferentiated ( proliferating ) cells come to predominate .
C1514964
differentiation
C0007634
cells