a multicenter , double-blind , randomized study compared 200 micrograms of misoprostol and placebo four times daily for four weeks in the treatment of 225 patients with duodenal ulcer ( 0.7 cm to 2.0 cm in size ) persisting after at least four weeks of adequate , conventional therapy with cimetidine or ranitidine .
C0013295
duodenal ulcer
C0034665
ranitidine