for assessing the clinical impact of nonlinearity in theophylline elimination , we examined the incidence of individuals with an apparent michaelis-menten kinetics ( percent change in plasma concentration exceeding that in dose by at least 50 % ) among asthmatic children ( n = 122 ) and adults ( n = 50 ) screened through a two-step chart review .
C0039771
theophylline
C0004096
asthmatic