however , the results suggest that tolbutamide may increase the liver f-2,6-p2 level by affecting the phosphorylation state of fructose-6-phosphate , 2-kinase/fructose-2,6-bisphosphatase through cyclic amp-dependent protein kinase , resulting in the stimulation of glycolysis and the inhibition of gluconeogenesis in the liver .
C0031715
phosphorylation
C0031727
kinase