using dot-hybridization with thymidine kinase gene ( tk gene ) of herpes simplex virus type 1 ( hsv 1 ) of dna preparations obtained from isolated metaphase chromosomes and lysate fractions of metaphase cells , which presumably contain smaller particles compared to metaphase chromosomes , it has been shown that the tk gene of hsv 1 is localized in chromosomes of cells of transformant clones unstable in tk+-phenotype .
C0025564
metaphase
C0007634
cells