while the cumulative renal excretion ( 0 to 48 hours after administration ) was reduced from 18.2 % in healthy volunteers to 2.3 % of the applied dose in kidney patients , the global elimination constant k fell from 0.104 h-1 in healthy volunteers to 0.072 h-1 in the patients with renal disease .
C0022646
kidney
C0022658
renal disease