other features of severe alteration of cns were observed in both patients , being the most significant lack of sphincter control at 13 and 7 years old , mental retardation with an iq about 70 , generalized seizures at 10 years in the older boy and presence of brain alterations at computerized tomography ( ct ) , consisting in low density on subcortical brain parenchima in both cerebral hemispheres and the cerebellum in the older brother and in both cerebral hemispheres in the younger .
C3714787
cns
C0006104
brain