we evaluated the cellular and humoral immune response to type ii collagen and the relative susceptibility to type ii collagen-induced arthritis ( cia ) in 14 inbred rat strains representing six rt1 specificities and including four congenic strain pairs differing only at rt1 , by using a standard protocol with native calf type ii collagen as the immunogen : wf ( rt1u ) was a high responder and susceptible ;
C0020967
humoral immune response
C0003320
immunogen