because of this potential clonal relationship , we can reach several conclusions about the diversity observed among these kappa light chains : ( i ) the diversity is due to somatic mutation , ( ii ) somatic mutations occur sequentially and accumulate in the first complementarity-determining region , and ( iii ) the extent of somatic variation in this sample is high , suggesting a somatic mutation rate of about 10 ( -3 ) per base pair per generation .
C0021036
kappa light chains
C0021024
complementarity-determining region