analysis of a genetic cross of plasmodium falciparum and of independent parasite isolates from southeast asia , africa , and south america indicates that resistance to pyrimethamine , an antifolate used in the treatment of malaria , results from point mutations in the gene encoding dihydrofolate reductase-thymidylate synthase ( ec 1.5.1.3 and ec 2.1.1.45 , respectively ) .
C0034283
pyrimethamine
C0024530
malaria