in a long-term follow-up ( median , 19 years ) of 241 patients with mgus , 53 ( 22 % ) developed multiple myeloma ( 36 patients ) , macroglobulinemia ( 7 patients ) , primary systemic amyloidosis ( 7 patients ) , or malignant lymphoproliferative disease ( 3 patients ) .
C0026764
multiple myeloma
C0281479
primary systemic amyloidosis