to test the hypothesis that datp and dgtp accumulation inhibit dna synthesis by inhibiting the enzyme ribonucleotide reductase , simultaneous rates of incorporation of [ ( 3 ) h ] uridine and [ ( 14 ) c ] thymidine into dna were measured in the presence of deoxyadenosine plus ehna or deoxyguanosine , and in the presence of hydroxyurea , a known inhibitor of ribonucleotide reductase .
C0598312
dna synthesis
C0035547
ribonucleotide reductase