6-nitrocholesterol has been shown to cause a 50 % reduction in the level of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in animal cells in culture at 1.9 microm and it has relative binding affinity for the cytosolic oxysterol binding protein of 357 nm in cell-free extracts from the same cell line .
C0007634
cells
C1383501
cytosolic