in experiments where only the hyperpolarizing action of baclofen was precluded by conventional current clamp techniques , 20 microm ( +/- ) baclofen blocked the early gaba-mediated ipsp and also a late hyperpolarization which , since it could be evoked by orthodromic stimulation subthreshold for spike firing , would not be expected to be produced by a ca2+-activated increase in potassium conductance ( ahp ) , but to be a transmitter-mediated event .
C0004609
baclofen
C0016904
gaba