the ultimate introduction of differentiation as a therapeutic approach to cancer treatment if attained , however , will require a variety of principles to be established , so that optimum efficacy may be obtained from each agent , the fabrication of new agents with major changes in the ratio of the concentrations required to produce cytotoxicity relative to those necessary to initiate maturation is attained , and the elucidation of non-antagonistic combinations of differentiation inducing agents with or without cytotoxic drugs is achieved to combat the problem of tumor cell heterogeneity .
C0007589
differentiation
C0007634
the