continuous exposure of freshly isolated chondrocytes from day 2 of culture to approximately half-maximal concentrations of il-1 ( 2.5 pm ) completely suppressed levels of type ii collagen mrna and increased levels of types i and iii collagen mrnas , thereby reversing the ratio of alpha 1 ( ii ) /alpha 1 ( i ) procollagen mrnas from greater than 6.0 to less than 1.0 by day 7 .
C0009325
collagen
C0033235
procollagen