eight chelators - 8-hydroxyquinoline , 1-hydroxypyridine-2-thione ( omadine ) , tropolone , pyridoxal isonicotinoyl hydrazone , 2-methyl-3-hydroxypyr-4-one ( maltol ) , 1-methyl-3-hydroxypyrid-2-one , 1,2-dimethyl-3-hydroxypyrid-4-one and mimosine -- and their iron complexes were tested on cells of the established human tumour cell lines k-562 ( erythroleukaemic ) and u-937 ( monoblastoid ) for their effects on a ) cellular accumulation of iron provided by transferrin ( tf ) via receptor-mediated endocytosis , b ) specific cell surface binding of tf , c ) cell viability and , d ) dna synthesis .
C0007634
cellular
C0597361
receptor-mediated endocytosis