the effects of exposure of cultured human diploid fibroblasts ( jhu-1 cells ) to sodium fluoride have been studied with respect to cytotoxicity and induction of chromosome aberrations and unscheduled dna synthesis ( uds ) cytotoxicity of naf on jhu-1 cells , as determined by a decrease in colony-forming ability , linearly increased with increasing dose of naf ( 50-150 micrograms/ml ) or exposure time ( 1-24 h ) .
C0016030
fibroblasts
C0007634
cells