nicotine exposure produced an elevation in transmitter turnover in central noradrenergic pathways with a regional selectivity reflecting the timetable of cellular development : the most profound effects were seen in late-developing regions ( cerebellum ) , intermediate effects were found in earlier-developing areas ( cerebral cortex ) and the least effect was obtained where maturation occurs earliest ( midbrain + brainstem ) .
C0025462
midbrain
C0006121
brainstem