in order to test whether bisphosphonates , which are potent inhibitors of osteoclastic bone resorption , may also act upon osteoblasts , we studied the effect of dichloromethylenebisphosphonate ( cl2mbp ) and 4-amino-1-hydroxybutylidene-1,1-bisphosphonate ( ahbubp ) on in vivo levels and in vitro release of osteocalcin , a bone-specific protein produced by osteoblasts .
C0012544
bisphosphonates
C0012081
dichloromethylenebisphosphonate