with a chemically defined medium that promotes limb mesenchymal cell proliferation and differentiation in vitro , it was demonstrated that : ( 1 ) no clear correlation exists between cellular nad content and the chondrogenic expression of cultured limb mesenchymal cells , ( 2 ) nicotinamide and benzamide compounds reduce cell proliferation and , at the higher doses tested , considerably reduce chondrogenesis in limb mesenchymal cell cultures , and ( 3 ) limb mesenchymal cells exhibit an enhanced susceptibility to benzamide compounds at a time very early in the culture period which temporally coincides with a transient increase in cellular adp-ribosylation activity and initial chondrogenic differentiation .
C0596290
cell
C0007634
cellular