we cloned a dna fragment directing synthesis of a-factor from the total cellular dna of streptomycin-producing streptomyces bikiniensis on the plasmid vector pij385 . introduction of the recombinant plasmid ( pafb1 ) into a-factor-deficient s. bikiniensis and streptomyces griseus mutants led to a-factor production in the host cells , as a result of which streptomycin production , streptomycin resistance , and spore formation of these mutants were simultaneously restored .
C0598312
dna
C0012854
dna