nuclei extracted from neocortex of patients with alzheimer 's disease and treated with micrococcal nuclease release a population of dinucleosomes that contain an increase in the linker histones h1o and h1oo . five other degenerative brain diseases that clinically resemble alzheimer 's disease do not result in these changes , although pick 's disease is associated with an increase in h1 on dinucleosomes .
C0007610
nuclei
C0019652
histones