in this study the specificity of circulating autoantibodies in ana+ aged donors , ana- donors and sle patients was investigated by immunoblotting on total nuclear proteins and by elisa on purified nuclear proteins , possibly related to dna metabolism , such as dna polymerase alpha , dna-dependent atpase , dna topoisomerase i , ssdbp , hnrnp , hmg and histones .
C0028589
nuclear proteins
C0019652
histones