in summary , these studies show : 1 ) that the h-35 cell igf-ii receptor is synthesized first as a 245-kda precursor having 4-6 high-mannose oligosaccharide side chains , 2 ) processing of the receptor oligosaccharides by mannose removal and terminal sialylation converts the 245-kda precursor to the 250-kda mature product which has been previously identified as the functional receptor in the plasma membrane , 3 ) the apparent molecular mass of the receptor in the absence of n-glycosylation is 232-kda , and 4 ) glycosylation of the igf-ii receptor is required for the acquisition of igf-ii binding activity .
C1334189
igf-ii receptor
C0007603
plasma membrane