a comparison of these results with earlier obtained data on the functional properties , of immobilized antibodies revealed that the decrease of antigen-binding characteristics of anti-cea after igg immobilization via nh2- and cooh-groups , carbohydrate moiety , tyrosine and histidine residues is due to the direct effect of antibody modification , whereas the changes in parameters of antibody interaction with antigen after igg immobilization via sh-groups , methionine and histidine residues is due to steric hindrances .
C2350610
immobilized antibodies
C0003241
antibody