other enzymes that showed significant decreases during aging are aldolase ( ec 4.1.2.13 ) , lactate dehydrogenase ( ec 1.1.1.27 ) , citrate synthase ( ec 4.1.3.7 ) , and nad+-linked isocitrate dehydrogenase ( ec 1.1.1.41 ) .
C0022917
lactate dehydrogenase
C0030016
ec 1