a chimeric plasminogen activator ( t-pa/scu-pa-s ) , consisting of amino acids 1-263 of tissue-type plasminogen activator ( t-pa ) and 144-411 of single-chain urokinase-type plasminogen activator ( scu-pa ) , was previously shown to maintain the enzymatic properties of scu-pa but to have only partially acquired the fibrin affinity of t-pa , possibly as a result of steric interaction between the functional domains of t-pa and scu-pa ( nelles , l. , lijnen , h. r. , collen , d. , and holmes , w.e . ( 1987 ) j. biol . chem . 262 , 10855-10862 ) .
C0032144
plasminogen activator
C0032143
t-pa