as reported in our previous paper ( sato et al. , cancer res. , 38 : 3086-3093 , 1978 ) , most of the hyperplastic hepatic nodules and primary hepatomas induced by n-2-fluorenylacetamide ( 2-faa ) , diethylnitrosamine ( dena ) , and 3'-methyl-4-dimethylaminoazobenzene ( 3'-me-dab ) showed that pyruvate kinase liver ( l ) type decreases and the prototypic m2 type increases concomitantly with dedifferentiation of tissues .
C0279000
primary hepatomas
C0023884
liver