although the difference between n-mustard concentrations leading to half maximal inhibition of histone acetylation in sensitive and resistant cells is considerably smaller than the difference between n-mustard doses required for half maximal inhibition of cell proliferation the data suggest that -- besides dna-dna cross-linking -- the inhibition of histone acetylation has to be considered as an important alternative mechanism responsible for the cytotoxic activity of alkylating agents .
C0007634
cells
C1156236
inhibition of cell proliferation