in a group of 61 patients with carcinoma of the breast and known tumour duplication time determined by serial mammography , it is shown that broadening of the conventional tumour grading by means of additional histopathological malignancy criteria ( frequency of mitosis , incidence of nuclear hyperchromasias , formation of tubules and nuclear irregularities ) correlates with the growth dynamics of the tumours .
C0027651
tumour
C0006826
malignancy