change in thyroid status from hyperthyroid to euthyroid produced no change in the elimination half-life ( t 1/2 ) of oral propranolol ( 3.2 +/- 0.5 to 4.1 +/- 0.7 hr ) , the oral clearance ( 38.4 +/- 7.3 to 27.4 +/- 2.4 ml/min/kg ) , the elimination t 1/2 of intravenous propranolol ( 2.5 +/- 0.3 to 3.5 +/- 0.7 hr ) , and the apparent volume of distribution ( 4.8 +/- 0.4 to 3.8 +/- 0.5 l/kg ) .
C0040132
thyroid
C0020550
hyperthyroid