oral administration of the artificial sweetener aspartame , 1 g/kg , or of an equimolar dose of its metabolite phenylalanine , to fasted rats 1 hour before slow i.v . infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal fluid concentrations of theophylline at the pharmacologic endpoint .
C0036572
seizures
C0039771
theophylline