spectrophotometric studies also revealed direct binding of ketoconazole to cytochrome p-450 component by inducing type ii difference spectra in all tissue preparations examined , indicating that ketoconazole is possibly a universal inhibitor of nadph-cytochrome p-450 dependent monooxygenases which are involved in metabolism of many substances including steroids , toxins , carcinogens and others .
C0010762
cytochrome p-450
C0025519
metabolism