it is concluded that the insulin binding and the insulin-dependent protein kinase are intrinsic components of the same oligomer since ( i ) they copurify to homogeneity , ( ii ) the purified receptor protein kinase is immunoprecipitated by polyclonal and monoclonal antibodies to the human insulin receptor , and ( iii ) phosphorylation of the beta subunit of the receptor occurs by an intramolecular reaction .
C0033640
protein kinase
C0031715
phosphorylation