1 ) estrogen receptor existed in 80 % of the rat ovarian cancers induced by dmba 2 ) in the estrogen injected group , a higher incidence and larger growth of the induced tumor were observed than in the hormonally non-treated group 3 ) a major difference between the histologic features of estrogen group and non-treated group was that the ovarian adenocarcinoma of the former , but not the latter , was associated with a significant proliferation of connected tissues and contained many signet ring cells involving intracytoplasmic canaliculi 4 ) ultrastructural findings of these cells were characterized by well developed microvilli , mitochondria , golgi complexes and abundant lipid droplets 5 ) the proliferation of the dmba-induced cancer cells in culture was promoted by 17 beta-estradiol application , suggesting its hormonal dependence .
C0007634
cells
C0018042
golgi