since activation of this kinase is known to be necessary , although not by itself sufficient for the transformation of cells by polyoma virus , bursts of protein kinase c activity , triggered by tpa or various cellular receptors , might enhance the oncogenicity of polyoma virus by stimulating this middle t antigen-associated phosphatidylinositol kinase .
C0031727
kinase
C0089793
phosphatidylinositol kinase