daily administration of indomethacin at 42 mumol/kg subcutaneously , but not of vehicle only , for 14 consecutive days , elevated the average mean arterial pressure in seven rabbits from 88 +/- 3 mmhg on the last day of the control period to 105 +/- 3 mmhg ( p less than 0.01 ) and 107 +/- 2 mmhg ( p less than 0.01 ) on days 6 and 14 of indomethacin treatment respectively , and reduced the urinary excretion of prostaglandin-like substance from 1.06 +/- 0.26 to 0.17 +/- 0.05 nmol of prostaglandin e2 equivalents/day ( p less than 0.05 ; n = 5 ) .
C0033554
prostaglandin
C0012472
prostaglandin e2