a simple calculation demonstrates that when the protein concentration is in large excess over the total ligand concentration , the exit of ligand follows quasi-first-order kinetics , the half-life being proportional to ( 1 + ( p ) /kd ) , where ( p ) is the concentration of binding sites , and kd the dissociation constant characteristic of the equilibrium between the ligand and the protein .
C0022702
kinetics
C0018517
half-life