in the first patient ( a 7-month-old female with acute monocytic leukemia ) extremely young age and previous chemotherapy with a podophyllotoxin derivative , vp-16 , may have prediposed the patient to fatal congestive heart failure at a total daunorubicin dose of only 225 mg/m2 .
C0018802
congestive heart failure
C0011015
daunorubicin