though the absence of standardized reporting of complications and the paucity of well-designed comparative studies mandate careful consideration of the variables of individual cases , we have made the following general recommendations : unoperated patients with rheumatic mitral valvular disease and atrial fibrillation should be chronically treated with warfarin , regardless of the hemodynamic severity of their valvular lesion .
C0004238
atrial fibrillation
C0043031
warfarin