the administration of red cell ghost encapsulated indolyl-3-alkane alpha-hydroxylase ( an enzyme which destroys tryptophan by oxidation of the side chains ) in cd-1 female mice causes effective tryptophan depletion in plasma and brain and induces hypothermia by probably decreasing the serotonin concentration in brain by decreasing the concentration of its precursor , l-tryptophan .
C0006104
brain
C0086045
concentration