mirroring the binding data , pirenzepine , dicyclomine and trihexyphenidyl showed a tenfold greater ability at inhibiting m1-receptor mediated ganglionic responses ( mcn a-343 pressor effect in pithed rats and nictitating membrane contraction in cats ) than at inhibiting peripheral muscarinic responses in the heart and cardiovascular smooth muscle ( vagal bradycardia in rats and cats and vagally-induced vasodilatation in cats ) .
C0018787
heart
C0007226
cardiovascular