forebrain catecholamine depletion and midbrain histological damage in adult male rats were investigated as a function of 6-hydroxydopamine dosage in the range 4 microgram in 2 microliter to 8 micrograms in 4 microliter , stereotaxically injected at 0.43 microliter/min bilaterally in the region of the ascending dorsal noradrenaline bundle of the locus coeruleus , without and with a 30-60 min earlier 25 mg/kg intraperitoneal dose of desmethylimipramine ( dmi ) .
C0007412
catecholamine
C0028351
noradrenaline