of 26 patients enrolled in a study designed to assess the usefulness of dipivalyl epinephrine 0.1 % , administered topically at 12-hour intervals , for lowering intraocular pressure in patients with glaucoma and ocular hypertension , six patients ( 23.1 % ) developed adverse external ocular side effects severe enough to require that the drug be discontinued .
C0017601
glaucoma
C0015392
ocular