when the administration of egf to insulin-pretreated hepatocytes was postponed for 44 h after plating in serum-free medium , the cellular sensitivity was increased as compared to egf treatment at 0 h ( a one-log shift of the dose-effect curve ) , the rate of s phase entry was more rapid , and the lag period for the onset of the egf effect ( i.e. , shift of rate constant ) was shortened ( 6-7 h vs. 26 h ) .
C0007634
cellular
C0080129
s phase