these data led us to propose that the synthesis of an sv40 okazaki piece could be itself discontinuous and could comprise the following steps : ( i ) irna synthesis by dna primase , ( ii ) irna extension into a dna primer by an aphidicolin-resistant activity associated with dna primase-dna polymerase alpha , ( iii ) removal of irna moieties between adjacent dna primers , ( iv ) `` '' gap filling '' '' between dna primers by the aphidicolin-sensitive dna polymerase alpha , and ( v ) ligation of dna primer units onto a growing okazaki piece .
C0598312
synthesis
C0058594
primase