the data reported here show that although the levels of secreted il-1 were equally high after in vitro stimulation with an optimal dose of lps or silica , there were two clear differences : ( i ) the levels of membrane-associated il-1 ( as detected by the comitogenic effect of paraformaldehyde ( pfa ) -fixed cells or purified membrane fragments on murine thymocytes ) were ca . five times higher after lps stimulation than after silica stimulation , ( ii ) the secreted il-1 after lps stimulation was mainly of the pi 7 ( il-1 beta ) type , while after silica stimulation there were equally high amounts of pi 7 and pi 5 ( i.e . il-1 alpha ) forms .
C0021755
il-1
C0021753
il-1 beta