isolates with acquired resistance to amikacin were resistant to the other 2-deoxystreptamine aminoglycosides but showed little or no change in minimal inhibitory concentrations to streptomycin , suggesting either a difference in cellular uptake between the 2 groups of drugs or , more likely , different binding sites on the ribosome .
C0002499
amikacin
C0002556
aminoglycosides