in 5 patients with hyponatremia and ascites resistant to a major diuretic treatment ( 200-400 mg spironolactone combined with 40-160 mg furosemide/day for 4 of them ) , urea intake ( 30-90 g/day ) induced the following changes : the daily weight changed from a gain of 0.01 +/- 0.06 kg/day to a loss of 1.03 +/- 0.12 kg/day ( p less than 0.001 ) ( mean +/- sem ) , serum sodium concentration rose from 128 +/- 1.3 to 133 +/- 1.4 mmol/l ( p less than 0.01 ) , sodium output increased from 24 +/- 4 to 82.5 +/- 11 mmol/day , diuresis increased from 1.05 +/- 0.10 to 2.24 +/- 0.24 liters/day ( p less than 0.01 ) .
C0003962
ascites
C0016860
furosemide