this enzyme , in lymphocyte membranes , has km for s-adenosylmethionine of 7.01 +/- 2.9 ( sd ) microm , and specific activity 0.57 +/- 0.31 pmol/mg protein/15 min , is inhibited by s-adenosylhomocysteine , displays optimal activity at ph 8.0-9.0 , and is stimulated by isoproterenol in dose-dependent , propranolol-inhibitable fashion , to a lesser extent by epinephrine , but not by norepinephrine , prostaglandin e1 , concanavalin a , or adenosine 3':5 ' cyclic monophosphate , with or without phosphodiesterase inhibitors .
C0036002
s-adenosylmethionine
C0001443
adenosine