if the extent of dopamine-sensitive adenylate cyclase stimulation is considered as a measure of dopaminergic activity , examination of the structure/dopaminergic activity relationship showed that modifications of ergot alkaloid molecules such as isomerization in position 8 , hydrogenation of delta 9 ( 10 ) -double bond , or introduction of bromine into position 2 of the molecule , lead to a significant decrease of stimulatory effects of adenylate cyclase .
C0013030
dopamine
C0282151
dopaminergic