using rous sarcoma hamster tumor cells as a model , treatment of monolayer cultures during exponential growth with 10 , 25 , and 50 microm mgbg ( up to 48 hr ) resulted in dose-dependent ( reversible ) growth inhibition and selective ultrastructural damage to the mitochondria ( e.g. , extreme swelling , loss of cristae and matrix components , and dense inclusions ) in up to 96 % of cells , while nuclei appeared normal , corroborating and extending findings by others in mouse , rat , and human cells .
C0007634
cells
C0007610
nuclei