at the concentrations used in the experiments , the drug differ in their toxicity ( fl5du greater than hu greater than apc ) , induction of unbalanced cell growth , and the distribution of new dna fragment sizes allowed during block , but they all ( 1 ) allow cells to enter s phase , ( 2 ) cause similar time-dependent losses of histone h1 per unit dna , which begin as synchronized g1 cells begin to enter s phase , ( 3 ) retard dna elongation beyond replicon size , and ( 4 ) retard the turnover of histone h1 .
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