since carlsson 's original suggestion that dopamine may be a transmitter in the central nervous system involved in the control of motor function and that it may be involved in the parkinsonian syndrome ( carlsson , 1959 ) , and the now-classic paper by ehringer and hornykiewicz ( 1960 ) which definitively showed the significant reduction of dopamine concentration in the neostriatum of cases of idiopathic parkinson and postencephalitic parkinsonism , the vast amount of work on the subject has focused on the biochemical and pharmacologic correlates of this dopaminergic system failure involving particularly the nigrostriatal pathways .
C0013030
dopamine
C0282151
dopaminergic