since free zn2+ is a potent inhibitor of numerous sulfhydryl-containing enzymes , including glutamic acid decarboxylase , we conclude that zinc-binding proteins not only may function as a physiological donors of zn2+ to zinc apometalloenzymes , but also may play a decisive role in preventing cns toxicity by preventing the rise of free zn2+ in the brain .
C3714787
cns
C0006104
brain