the heparin-sensitive binding of 125i-ldl to cell homogenate particulates represents ldl bound to its cell surface receptor as judged from the following criteria : ( a ) it was quantitatively similar to the heparin-sensitive binding of 125i-ldl to intact cells , ( b ) it showed a direct correlation to the receptor-mediated degradation of 125i-ldl by intact cells , ( c ) no heparin-sensitive binding could be detected in homogenates prepared from normal erythrocytes or from cultured fibroblasts from a patient with homozygous familial hypercholesterolemia ( two types of cell lacking ldl receptors ) , ( d ) it was dependent on calcium and inhibited by edta , ( e ) it was susceptible to treatment with pronase , and ( f ) it was heat-labile .
C0007634
cell
C0016030
fibroblasts