a single topical application of 17 nmol 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) to the skin of hairless mice induces characteristic transient alterations in the epidermal cells turnover and maturation ( 0.96 h ) , associated in time with characteristic changes in the activities of l-ornithine carboxy-lyase ( e.c . 4.1.1.17 ) ( odc ) and s-adenosyl-l-methionine carboxy-lyase ( e.c.4.1.1.50 ) ( sam-d ) and in the accumulation of polyamines .
C0029282
ornithine carboxy-lyase
C0007054
carboxy-lyase