however , when the nascent pn-dna was specifically removed by digestion of replicating viral chromosomes with escherichia coli exonuclease iii ( 3'-5 ' ) and phage t7 exonuclease ( 5'-3 ' ) , subsequent digestion of the remaining chromatin with mnase revealed the same degree of hypersensitivity observed prior to exonuclease treatment .
C0008633
chromosomes
C0008546
chromatin