as with the induction of microsomal enzymes , the augmentation of smooth endoplasmic reticulum , and the increase of rna- and protein-synthesis , excessive dna-polyploidization of liver cell nuclei appears to be an expression of hepatocellular hypertrophy due to the functional or metabolic stress imposed upon the liver by large quantities of phenobarbital .
C0035668
rna
C0597295
protein-synthesis