estradiol administration to young mice induced a complete translocation of cytosolic estrogen receptors to the nucleus , and two types of nuclear binding sites were observed : type i were specific for estrogens with high affinity ( kd = 0.51 +/- 0.06 x 10 ( -9 ) m ) and low binding capacity ( 115.1 +/- 22.7 fmol/mg dna ) and sedimented in the 4.0 s area , while type ii binding sites showed a much higher capacity and lower affinity for r2858 .
C0034804
estrogen receptors
C0007610
nucleus