none of the other drugs had any significant effects on the concentration of 5-ht , 5-hiaa or 5-ht synthesis rate in brain or spinal cord.9 experiments with compounds structurally related to quipazine and with molecular models suggested that quipazine produces behavioural changes probably by stimulating the 5-ht receptor in a similar way to 5-ht but that it would bind weakly , in agreement with ligand-receptor binding studies.10 it is suggested , therefore , that cyproheptadine , cinanserin and mianserin fail to inhibit 5-ht and 5-meodmt-induced behaviours because they are weak antagonists whilst they are able to inhibit the same behaviours induced by quipazine because it is a weak agonist.11 these data indicate that extreme care should be taken in accepting or rejecting 5-ht as a mediator of behaviours or of other responses unless several antagonists or agonists have been examined .
C0006104
brain
C0004927
behaviours