administration of a specific inhibitor of gamma-glutamylcysteine synthetase , such as buthionine sulphoximine , leads to a rapid decline in the glutamylcysteine synthetase , such as buthionine sulphoximine , leads to a rapid decline in the glutathione level of the kidney and other tissues , reflecting the appreciable rate of glutathione utilization .
C0017037
glutamylcysteine synthetase
C0054252
buthionine sulphoximine