we hypothesized that black patients with uncontrolled hypertension and low plasma renin activity on usual-dose hydrochlorothiazide therapy ( ie , 50 mg/d ) would respond better to higher doses of hydrochlorothiazide ( ie , 100 to 150 mg/d ) than to a usual-dose diuretic and metoprolol .
C0020538
hypertension
C0025859
metoprolol