procarbazine ( natulan ) is a potent inducer of gene mutations at the heterozygous tk +/- locus in l5178y mouse lymphoma cells in the presence of aroclor-induced rat liver s9 metabolic activation ( approximately 10 ( -3 ) mutant frequency at 10 micrograms/ml ) while exerting a far weaker effect in the absence of s9 .
C1708726
locus
C0007634
cells