in 1980 , the french cooperative group on chronic lymphocytic leukemia started a randomized clinical trial in which 612 good prognosis patients ( stage a ) received either no treatment ( 309 patients ) or an indefinite course of chlorambucil at the daily dose of 0.1 mg/kg ( 303 patients ) .
C0023434
chronic lymphocytic leukemia
C0008163
chlorambucil