in attempting to understand the causes of the hyperglycaemia observed in aging populations and to determine the mechanism ( s ) for the diminished in vitro insulin release from islets of langerhans of older rats , the adenylate cyclase-cyclic amp system was studied in isolated islets from 12 month old and 2 1/2 month old ( control ) male rats to determine its role in this altered insulin secretion .
C0020456
hyperglycaemia
C0021641
insulin