this capacity was associated with 10-fold increase in odc activity in the dialysed extracts of drug-resistant myeloma cells , markedly enhanced synthesis rate for odc enzyme molecules , as revealed by a 20 min [ 35s ] methionine labelling of cellular proteins , followed by specific immunoprecipitation and sds/polyacrylamide-gel electrophoresis , dose-dependently increased expression of odc mrna in resistant cells ( effective dose causing 50 % inhibition ) , dose-dependent amplification of odc gene sequences in a 9-kilobase-pairs ecori genomic dna fragment , and ( v ) a 10-fold increase in the ed50 ( effective dose causing 50 % inhibition ) for the anti-proliferative action of dfmo in these myeloma cells .
C0029282
odc
C1417932
odc gene