we have screened a large series of primary human leukemias for activating point mutations at codons 12 , 13 and 61 of the n-ras and k-ras proto-oncogenes and at codons 12 and 61 of the h-ras proto-oncogene by using panels of oligonucleotide probes in conjunction with polymerase chain reaction gene amplification .
C0086418
human
C0034678
ras