a single local injection of 2.5 mumol of n-hydroxy-n-formyl-2-aminofluorene ( n-hydroxy-faf ) , n-hydroxy-n-acetyl-2-aminofluorene ( n-hydroxy-aaf ) , or n-hydroxy-n-pro-pionyl-2-aminofluorene ) n-hydroxy-paf ) to each of the six left mammary glands of female sprague-dawley derived cd rats gave a mammary tumor incidence , after 12 months , of 53 % for the n-acetyl ( 42 % adenocarcinoma , 11 % fibroadenoma ) , 41 % for the n-formyl ( 8 % adenocarcinoma , 11 % sarcoma , 22 % fibroadenoma ) , and 33 % for the n-propionyl ( 11 % adenocarcinoma , 22 % fibroadenoma ) derivatives of n-hydroxy-n-2-aminofluorene , latent periods for malignant tumor appearance ( adenocarcinoma or sarcoma ) was 210 days , 148 days , and 177 days , respectively , with no malignant tumors occurring in the vehicle-treated animals .
C1261473
sarcoma
C0006826
malignant tumors