compared to controls , mice receiving morphine sulfate ( 10 mg/kg , sc ) 3 hr prior to naloxone had a 28 % increase in naloxone concentration in brain ( 200 to 260 pmol of naloxone per g of brain ) 10 min after 3h-naloxone-hcl ( 0.4 mg/kg , 11.0 micronci/kg , sc ) administration .
C0086045
concentration
C0006104
brain