thirty second exposure to 5-fu more than 100 micrograms/ml caused significant inhibition of cell growth and morphological changes such as decrease of mitotic cells , increase of vacuoles in the nucleus and cytoplasm , chromatin clumping against the nuclear membrane and formation of white-yellowish granules in the cytoplasm and scanning electron microscopy showed reduction of microvilli and filopodia .
C0042219
vacuoles
C0010834
cytoplasm