recent evidence from our laboratory has established that a phosphatidylinositol ( pi ) kinase , which phosphorylates the d-3 position of the inositol ring ( pi 3-kinase ) , is associated with many activated protein-tyrosine kinases and may play an important role in the signaling of cell proliferation ( auger , k. r. , serunian , l. a. , soltoff , s. p. , libby , p. , and cantley , l. c. ( 1989 ) cell 57 , 167-175 ) .
C0033681
protein-tyrosine
C0037083
signaling