from current data and the records of previously-published reactions to chloroquine , during fever or malarial chemotherapy in man and some mammals , the possible involvement of racial and skin pigment factors , histamine factor , other peripheral mediators of itch , tissue pharmacokinetic factors , central mediators of itch , pyrogenic haemodynamics , and 'gateway ' modulation in producing enhanced pruritic reaction during chloroquine antimalarial chemotherapy , were examined in relation to the aggravating role of ischaemia on itch excitability .
C0024530
malarial
C0008269
chloroquine