70 female wistar rats ( n = 10/test series ) were treated over five days at dosage intervals of 12 hours with intraperitoneal injections ( injection volume : 10 ml/200 g body weight ) of isotonic 0.9 % nacl , cilastatin ( 1000 mg/kg/day ) , imipenem ( 500 and 1000 mg/kg/day ) , cilastatin + imipenem ( 500 or 1000 mg/kg/day each ) and cefsulodin ( 1000 mg/kg/day ) .
C0008777
cilastatin
C0071972
cilastatin