feeding of a vitamin k-deficient diet caused the development of hypoprothrombinemic changes in rats such as prolongation of prothrombin time ( pt ) and activated partial thromboplastin time ( aptt ) , decreases in plasma prothrombin and clotting factor vii levels , and an increase in the descarboxyprothrombin ( pivka ) level in both plasma and liver .
C0015502
clotting factor vii
C0023884
liver