the dpn-specific isocitrate dehydrogenase of pig heart is totally and irreversibly inactivated by 0.05 m potassium cyanate at ph 7.4 a plot of the rate constant versus cyanate concentration is not linear , but rather exhibits saturation kinetics , implying that cyanate may bind to the enzyme to give an enzyme-cyanate complex ( k equal 0.125 m ) prior to the covalent reaction .
C0014442
enzyme
C0026741
enzyme