a specific anatomical lesion sharply localized to the cells of the medullary thick ascending limbs ( mtal ) and characterized by mitochondrial swelling progressing to nuclear pyknosis and cell death is elicited reproducibly in isolated rat kidneys perfused for 15 or 90 min with cell-free albumin-ringer 's medium gassed with 5 % co2 , 95 % o2 ( o2 content , 1.5 vol/100 ml ) .
C0007634
cells
C0007587
cell death