since salbutamol itself is a potent inhibitor of mast cell degranulation and histamine release , the present findings suggest that histamine may be released and sequestered within the lungs during carbachol-induced-bronchospasm , and also that desequestration of bronchoconstrictor mediators accumulated at the point of contact of bronchial smooth muscle may contribute to the relief of bronchospasm by salbutamol .
C0024109
lungs
C0006266
bronchospasm