since the action of gelsolin on actin is reversible and dependent on physiologically relevant changes in calcium concentration , the localization of gelsolin , together with actin-bundling proteins such as alpha-actinin , in the regions containing many small microfilament bundles on the ventral side of cytoplasm suggests that gelsolin may be a component of the mechanism for the disassembly and assembly of actin during the dissolution and reformation of structures for cell-substratum contact during cell locomotion .
C0025979
microfilament
C0001271
actin