a series of pt-amine compounds was assayed for their ability to inhibit the growth of cultured l1210 leukemia cells [ median inhibitory dose ( ld50 ) ] , their toxicity in mice [ highest nonlethal dose in healthy mice ( ld0 ) ] , their antitumor activity against leukemia l1210 cells grafted intraperitoneally into mice [ mean survival of treated leukemic mice : mean survival of untreated leukemic mice ( t/c ) ] , and the ability to hydrolyze their labile ligands in vitro [ hydrolysis half-time ( t1/2 ) ] .
C0007595
growth of
C0007634
cells