the increased efficiency of neoplastic transformation by v-ha-ras of cell lines as compared with our previous results with normal bronchial epithelial cells [ yoakum et al. , science 227:1174-1179 , 1985 ] is consistent with the hypothesis that the `` '' immortalization '' '' step is rate-limiting in in vitro human epithelial cell carcinogenesis .
C0007621
neoplastic transformation
C1336923
v-ha-ras