because interleukin 1 has been shown to be cytotoxic to beta-cells in isolated rat islets of langerhans and since interleukin 1 has a calcium ionophore effect on other cell types , this study was designed to test whether alterations of the calcium flux across the beta-cell membrane would influence the effects of interleukin 1 on isolated rat and mouse islets .
C0022131
islets of
C0030281
beta-cell