we therefore attempted to make soluble derivatives without breaking the delta-lactone ring and obtained 7-ethyl-10- [ 4- ( 1-piperidino ) -1-piperidino ] -carbonyloxy-cpt ( cpt-11 ) , which showed very strong antitumor activity by i.p. , i.v . or p.o . administration against the ascites type of l1210 leukemia , p388 leukemia , sarcoma 180 , meth a fibrosarcoma , b16 melanoma , ehrlich carcinoma and mh134 hepatoma and the solid type of sarcoma 180 , meth a fibrosarcoma , lewis lung carcinoma , c3h/hen mammary carcinoma , ehrlich carcinoma and mh134 hepatoma .
C0243038
lewis lung carcinoma
C0007097
carcinoma