hence , the inhibition of this rate may be an important function underlying the complement-mediated processing of immune complexes , and a decreased ability of the complement system to mediate this process in the presence of c4b1 , in contrast to c4a3 , could explain , at least in part , the association between the c4a-null phenotype and autoimmune diseases such as systemic lupus erythematosus .
C0004364
autoimmune diseases
C0024141
systemic lupus erythematosus