the activity of microsomal drug-metabolizing enzymes is altered by several pathological or abnormal physiological states , such as changes in nutritional status , liver , heart or kidney diseases , hormonal disturbances , pregnancy , tumour-bearing state , adjuvant arthritis , changes in reticuloendothelial system and environmental factors ( stress , irradiation , heavy metals ) .
C2916830
physiological states
C0032961
pregnancy