to study the effect of iron-overload on hepatic lipid peroxidation , two rat models of haemochromatosis were employed : in the first model resembling secondary haemochromatosis , repeated i.p . injections with fe-dextran led to an accumulation of fe in kupffer cells , while in the second model resembling hereditary haemochromatosis , iron was located mainly in periportal hepatocytes after feeding on a diet containing 3.5 % fe-fumarate for 3 weeks .
C0018995
haemochromatosis
C0302583
iron