in a double-blind , randomized trial of 553 infants and children who had otitis media with effusion ( `` '' secretory '' '' otitis media ) , we compared the efficacy of a four-week course of an oral decongestant-antihistamine combination ( pseudoephedrine hydrochloride , 4 mg per kilogram of body weight per day , and chlorpheniramine maleate , 0.35 mg per kilogram per day ) with that of placebo .
C0021270
infants
C0008059
children