the prepubertal ontogeny of endocrinological responsiveness to estradiol in the central nervous system of the female rat is examined in the context of several of the important factors that are known to influence the functional development of the hypothalamo-pituitary-gonadal circuit : the rapidly changing hormonal environment of the morphologically and physiologically immature juvenile rat , the shifting predominance of alphafetoprotein and `` '' adult '' '' estradiol-binding protein , sexual differentiation of the neural substrate , and the development of mature pituitary-gonadal feedback mechanisms .
C0002210
alphafetoprotein
C0242210
l-bindi