in contrast , modifications near the b-chain of insulin to form either des- ( 31,32 ) hpi or split ( 32-33 ) hpi resulted in roughly a 5-fold increase in affinity , whereas a cleavage within the connecting peptide to form split ( 56-57 ) hpi showed only a 2-fold increase in affinity as compared to intact hpi .
C0006558
connecting
C0033362
hpi