the diagnosis of heart failure in neonates with ductal dependent congenital cardiac lesions ( such as coarctation of the aorta , hypoplastic left heart syndrome or pulmonary valve atresia ) allows the early institution of alprostadil ( prostaglandin e1 ) therapy to maintain patency of the ductus arteriosus , which stabilises these infants before surgical therapy .
C0002335
prostaglandin e1
C0013274
patency