thus , poca can be used as a tool to distinguish different forms of insulin resistance in obesity : 1 ) a lipid metabolism-dependent defect -- presumably an inhibition of phosphofructokinase and pyruvate dehydrogenase by metabolites of fatty acid oxidation , influenced by inhibition of carnitine palmitoyltransferasei , and 2 ) a lipid metabolism-independent defect in the activation of uptake of glucose and glycogen synthesis by insulin not affected by poca .
C0598783
lipid
C0021641
insulin