in order to clarify the role played by immunologically derived cytokines in dermal connective tissue synthesis and degradation , we investigated the effect of human recombinant ( hu-r ) interleukin ( il ) 1-alpha and beta , hu-r tumor necrosis factor ( tnf ) -alpha and beta , hu-r il 2 , and hu-r granulocyte-macrophage colony-stimulating factor ( gm-csf ) on the production of collagen , glycosaminoglycan , fibronectin , and collagenase activity by three lines of cultured human adult dermal fibroblasts .
C0086418
hu-r
C0021756
hu-r il 2