( 3 ) the finding of falsely normal levels of alpha-iduronidase in chorionic villus samples from a pregnancy affected with hurler 's disease , probably due to contamination with maternal tissue which has relatively high levels of this enzyme compared with fetal chorionic material : ( 4 ) the inadequacy of indirect assays of incorporation of radiolabel into macromolecules using chorionic villi , for example [ 14c ] propionate incorporation for prenatal diagnosis of methylmalonic aciduria .
C1442485
alpha-iduronidase
C0086795
hurler 's disease