aminoglycosides such as gentamicin are hydrophilic , polycationic drugs which bind to negatively-charged phospholipid bilayers , inhibit the activities of the lysosomal enzymes involved in the degradation of the major phospholipids and cause , in kidney in vivo or in cultured cells , a lysosomal phospholipidosis .
C0002556
aminoglycosides
C0017436
gentamicin