it is concluded that , at higher concentrations than those attainable in the brain or in the plasma during surgical anaesthesia in man , alphaxalone has a 'local anaesthetic-like ' action on the peripheral nervous system in that it specifically and differentially interacts with k and na channel gating systems : it is suggested that the anaesthetic would preferentially modify open k and inactivated na channels .
C0006104
brain
C0870814
action