the plan involves : ( a ) the chemical synthesis of 26 deoxyribooligonucleotide segments , ( b ) polynucleotide ligase-catalyzed joining of several segments at a time to form a total of four dna duplexes with appropriate comlementary single-stranded ends , and ( c ) the joining of the duplexes to form the entire dna duplex .
C0000702
a
C0012854
dna