as part of a program in which we are attempting ( a ) to obtain more potent and/or more selective antagonists of the antidiuretic responses to arginine-vasopressin ( avp ) and ( b ) to delineate the structural features at positions 1-9 required for antidiuretic antagonism , we have synthesized 13 new analogues of the antidiuretic antagonist [ 1- ( beta-mercapto-beta , beta-pentamethylenepropionic acid ) ,2-d-isoleucine,4- valine ] arginine-vasopressin [ d ( ch2 ) 5 [ d-ile2 ] vavp ] in which the valine residue at position 4 has been replaced by the l-amino acids abu , ile , thr , ala , ser , nva , gln , leu , lys , cha , asn , orn , and phe and two new analogues of the antidiuretic antagonist [ 1- ( beta-mercapto-beta , beta-pentamethylenepropionic acid ) ,2-d-phenylalanine,4- valine ] arginine-vasopressin [ d ( ch2 ) 5 [ d-phe2 ] vavp ] with the val4 residue replaced by ser and orn .
C0002520
amino acids
C0017797
gln