at 37 degrees c the relative affinity of 3-keto-desogestrel , the major metabolite of desogestrel , for the progesterone receptor in intact mcf-7 cells was twice that of levonorgestrel and org 2058 , three times that of medroxy-progesterone acetate ( mpa ) , 4.5 times that of norethisterone and 5 times that of progesterone and cyproterone acetate whereas at 4 degrees c in the cytosol fraction of mcf-7 cells exposed to molybdate ( nontransformed receptor complexes ) 3-keto-desogestrel and org 2058 displayed similar affinity .
C0057558
desogestrel
C0047683
3-keto-desogestrel