it has been concluded that the swollen pinealocytes represent a degenerative cell form probably occurring by impairment of plasmalemmal ca2+-atpase 's ability to eliminate ca2+ ion from the cell , with consecutive increase of calcium in the cytoplasmic matrix , followed by increase of intramitochondrial ca2+ concentration , gradual arrest of mitochondrial function , depolymerization of cytoskeletal microtubuli , loss of the cell form , and cell death .
C1383501
cytoplasmic matrix
C0007634
cell