consistent with a potential role for vacuolar ph in protein sorting , we found that bafilomycin a1 , a specific inhibitor of the vacuolar atpase , as well as the weak base ammonium acetate and the proton ionophore carbonyl cyanide m-chlorophenylhydrazone , collapse the ph gradient across the vacuolar membrane and cause the missorting and secretion of two vacuolar hydrolases in wild-type cells .
C1519906
vacuolar
C0042219
vacuolar