under conditions of continuous infusion to attain plasma folate levels of 2.3-5.7 pmol/ml , the urinary clearance based on chromatographic analyses of plasma and urine after correction for plasma folate binding was 0.20 ml/min for folic acid , 0.37 ml/min for 5-ch3 thf , and 1.76 ml/min for methotrexate .
C0016410
folic acid
C0025677
methotrexate