to explore the mechanism of insulin receptor phosphorylation we have used nih3t3 cells transfected with two receptor constructs : one encoding a chimeric receptor composed of the extracellular domain of the human egf receptor and the cytosolic domain of the human insulin receptor beta-subunit , and a second construct encoding a kinase-defiecient human insulin receptor .
C0031715
phosphorylation
C0031727
kinase