compared to controls , mice given anti-micro ( a ) had very few germinal centers in spleen and lymph node , ( b ) had decreased numbers of mature plasma cells synthesizing igm and igg1 in spleen , and virtual absence of iga-synthesizing plasma cells in the gut , ( c ) had greatly diminished numbers of b lymphocytes bearing membrane-bound immunoglobulins of the igm , igg1 , igg2 , and iga classes in spleen , ( d ) had reduced synthesis of igm , igg2 , and iga by in vitro spleen cultures , and ( e ) had significant decreases in serum levels of igm , igg1 , igg2 , and iga .
C1710156
germinal centers
C0037993
spleen