fibroblast hyperplasia and accumulation of fibrous material in the bone marrow of patients with idiopathic ( primary ) or secondary myelofibrosis ( mf ) is believed to result from a reaction by marrow fibroblasts to an altered marrow microenvironment , the alteration being potentiated by abnormal hemic cells .
C0005953
bone marrow
C0242006
secondary myelofibrosis