recent data from several studies have suggested that the non-protease domains in tissue-type plasminogen activator ( t-pa ) and urokinase-type plasminogen activator ( u-pa ) determine their biological specificities , including binding to fibrin clots and survival in the circulatory system ( van zonneveld , a.-j. , veerman , h. , and pannekoek , h. ( 1986 ) proc . natl . acad . sci . u. s. a . 83 , 4670-4674 ; rijken , d. c. , and emeis , j. j . ( 1986 ) biochem . j . 238 , 643-646 ) .
C1514524
protease domains
C0042071
urokinase-type plasminogen