throughout therapy , which was planned for 54 weeks , intrathecal chemoprophylaxis using methotrexate , cytosine arabinoside , and hydrocortisone was coordinated with the high-dose methotrexate infusion therapy to provide cns chemoprophylaxis that maintained therapeutic methotrexate spinal fluid levels ( greater than 10 ( -6 ) mol/l ) for approximately 60 hours .
C3714787
cns
C0007806
spinal