major differences were evident in the distribution of igg subclass antibodies between the infected groups : the response to larval and adult antigens is poor or absent in igg1 , igg2 and igg3 in untreated chronic infections but is high in igg4 , whereas in acute cases with hepatosplenomegaly and in school-children igg1 , igg2 and igg3 antibodies to larval antigens are in high titre but igg4 and igm responses to larvae are low or absent , the response in these isotypes being restricted in these cases to adult and egg antigens .
C0003241
antibodies
C0020860
igg4