lowering of glutathione levels with buthionine sulfoximine ( bso ) , which irreversibly inhibits the enzyme gamma-glutamyl cysteine synthetase , leads to a marked potentiation of the cytotoxicity of melphalan both in vitro and in vivo in a nude mouse model of human ovarian cancer .
C0054252
bso
C0017037
gamma-glutamyl cysteine synthetase