two important questions that are relevant for the understanding of the immune response in leprosy as well as for the design of rational immunoprophylaxis and -therapy strategies are : ( a ) what are the antigens that trigger t cell responses in tuberculoid patients and thus protect these individuals from developing lepromatous leprosy and ( b ) is it possible to restore t cell responsiveness to m. leprae in lepromatous patients by rechallenging the immune system with selected antigens that will trigger help but not suppression ?
C0301872
immune response
C0003320
antigens