in a search for a replication complex , the activity that replicates the 2-micrometers yeast dna plasmid in vitro was isolated in a high molecular weight form ( mr approximately 2 x 10 ( 6 ) by gel filtration and rate-zonal sedimentation from extracts prepared from cells of the budding yeast saccharomyces .
C0598312
replication
C0012854
dna