to analyze the influence of ricin b-chain on the toxicity of hybrid-protein conjugates , the rate of cellular uptake of conjugates , and the rate at which ricin a-chain ( rta ) is delivered to the cytoplasm , we have constructed toxic hybrid proteins consisting of epidermal growth factor ( egf ) coupled in disulfide linkage either to ricin or to rta .
C0007634
cellular
C0010834
cytoplasm