these abnormalities include ( 1 ) a marked reduction of pulmonary macrophage population which is normally elevated by smoke inhalation , ( 2 ) an accumulation of surfactant and flocculent material in alveoli , ( 3 ) a decrease in alveolar space surrounded by normal septal tissue , and ( 4 ) an increase in hypertrophied alveolar parenchyma .
C0085236
pulmonary macrophage
C1515933
alveoli