the most useful cellular modifications for the diagnosis of the noninfiltrative malignant process of epithelial origin are : the cellular pleomorphism ( anisocytosis and especially anisokaryosis ) , large nuclei in comparison with cell dimensions determining modifications of the nucleo-cytoplasmic ratio , the presence of hypertrophic nucleoli , respectively giant and/or multiple nucleoli with the change of the nucleolo-nuclear ratio in favour of the nucleolus , a large percentage of mitoses ( more than 20 mitoses per thousand cells ) , respectively more than 4 mitoses in the microscopic field at a high magnification .
C0007634
cellular
C0010834
cytoplasmic