a single intraperitoneal injection of nicotinamide ( 100 mg/kg body wt . ) , an endogenous non-toxic metabolite , to male rats was shown to significantly induce all the components of the hepatic microsomal mixed function oxidase system such as nadph-cytochrome c reductase , cytochrome p-450 and cytochrome b5 as well as activities of drug-metabolizing enzymes such as arylhydrocarbon hydroxylase , aminopyrine demethylase and udpglucuronosyltransferase .
C0010762
cytochrome p-450
C0003927
arylhydrocarbon hydroxylase