despite a favorable cardiovascular risk profile and control for the major known risk factors for heart disease , women reporting postmenopausal estrogen use at one or more examinations had over a 50 per cent elevated risk of cardiovascular morbidity ( p less than 0.01 ) and more than a twofold risk for cerebrovascular disease ( p less than 0.01 ) after the index examination .
C0007226
cardiovascular
C0018799
heart disease