to investigate the role of dna interstrand crosslink formation on cytotoxicity and the induction of sister chromatid exchanges ( sces ) , we treated 9l cells with the bifunctional mustard bis ( 2-chloroethyl ) methylamine ( hn2 ) , which can alkylate dna and form dna interstrand crosslinks , or with two monofunctional mustards , bis ( ethyl ) -2-chloroethylamine and bis ( methyl ) -2-chloroethylamine , which can only alkylate dna .
C0037211
sister chromatid exchanges
C0007634
cells