propranolol prolonged diazepam elimination t1/2 ( 58 and 49 hr ) , reduced its clearance ( 0.20 and 0.24 ml/min/kg ) , and increased the 168-hr auc for desmethyldiazepam , the major metabolite of diazepam ( 5.63 and 4.81 micrograms/ml . hr ) .
C0011279
desmethyldiazepam
C0012010
diazepam