in a review of fundus photographs , changes in the degree of depigmentation or atrophy of the retinal pigment epithelium ( rpe ) were observed near the disc over time in 21 % of cases with progressive glaucomatous cupping , but they also occurred as a natural phenomenon over time in 4 % of eyes with nonprogressive glaucoma and in 3 % of nonglaucomatous eyes .
C0017601
glaucoma
C0015392
eyes