chronic treatment with tgf-beta ( 100 pm , 9 d ) was associated with accumulation of cells in the g2 phase of the cell cycle in the virtual absence of cells in s phase , whereas subsequent removal of tgf-beta from these cultures was associated with the appearance of a significant fraction of cycling cells with greater than 4c dna content , consistent with development of tetraploidy .
C0007634
cells
C0079396
g2 phase of