to determine the effect of impaired liver function on conversion of prednisone to prednisolone , and to investigate the relationship of this to responses to treatment with prednisone , we measured serum prednisone and prednisolone by radioimmunoassay after 10 mg of prednisone was given by vein to 10 healthy volunteers , 6 untreated patients with severe chronic active liver disease ( cald ) , 10 patients with prednisone-induced remission of cald , and 3 patients with cald deteriorating despite treatment with prednisone .
C0023884
liver
C0023895
of cald