in the 4 patients on d-penicillamine for a year , a second liver biopsy showed that mean liver-copper concentration fell from 310 +/- 128 ( s.e.m . ) to 84 +/- 36 microng/g dry liver , compared with a reduction from 511 +/- 169 to 454 +/- 128 in the 7 patients in the placebo group in whom serial liver-copper measurements were available .
C0193388
liver biopsy
C0023884
liver