patients with four or more positive nodes or at least one positive apical node were randomized to receive either five or ten cycles of cyclophosphamide/adriamycin ( adria laboratories , columbus , oh ) ( ca ) and patients with one to three positive nodes or operable tumors larger than 5 cm and pathologically negative nodes were randomized to receive eight cycles of either cyclophosphamide , methotrexate , and 5-fluorouracil ( 5-fu ) ( cmf ) or methotrexate and 5-fu ( mf ) chemotherapy .
C0010583
cyclophosphamide
C0950521
cmf