since single drug therapy of chronic lymphocytic leukemia ( cll ) has not resulted in prolonged remissions of advanced disease , we initiated a program of combination chemotherapy , cop ( cycloposphamide , vincristine sulfate , prednisone ) for cll patients with increasing adenopathy , spenomegaly , and/or signs of marrow failure defined as either anemia or thrombocytopenia .
C0023434
cll
C0497156
adenopathy