the binding of the drug to chromatin , either in vitro or in the nuclei , induces two structural changes of chromatin : ( a ) an unfolding of the overall structure which results in an activation of the rate of degradation of chromatin by micrococcal nuclease and ( b ) a disorganisation of the core particle structure leading to the unwrapping of the dna from the histone core .
C0007610
nuclei
C0019652
histone