based on the activity of thrombin quick i in the reactions investigated , it is concluded that 1 ) the three cellular responses studied are initiated by proteolytic action of thrombin , 2 ) thrombin stimulation of aggregation and thromboxane release from platelets occurs via two different receptors , 3 ) the thrombin cellular interaction resulting in platelet aggregation and prostacyclin release must involve the thrombin active site as well as a secondary binding site required for optimal interaction with fibrinogen , and 4 ) the release of thromboxane from platelets does not involve the interaction of thrombin at the extrinsic binding site .
C0007634
cellular
C0032176
platelet aggregation