we studied a thiamine-dependent enzyme , transketolase , from fibroblasts of a diabetic patient who developed wernicke 's encephalopathy when treated with tolazamide , in order to delineate if this patient also had transketolase abnormality [ high km for thiamine pyrophosphate ( tpp ) ] , as previously reported in postalcoholic wernicke-korsakoff syndrome .
C0039840
thiamine
C0043121
wernicke 's encephalopathy