both hypoxia and endotoxin significantly compromised lysosomal stability as evidenced by large increases in circulating levels of cathepsin d , large increases in the nonsedimentable fraction of tissue cathepsin d ( ie , increased percentage of free activity ) , and changes in the ultrastructural appearance of liver lysosomes associated with enhanced fragility ( eg , swelling , increased vacuolization ) .
C0007427
cathepsin d
C0024369
lysosomes