during the first 24 hours after treatment three progressive manifestations of the degenerative process were seen : ( 1 ) a relatively mild condition which was characterized by surface irregularities produced by cell protrusions , highly vacuolated cytoplasm , presence of large lysosome-like bodies and prominent intercellular spaces , ( 2 ) a more severe condition in which large areas of the epithelium were detached from the basement membrane cellular debris was present in the nasal chamber , and ( 3 ) a condition of total or near-total denudation of the epithelium of olfactory mucosa .
C0010834
cytoplasm
C0007634
cellular