the high affinity of t-pa for plasminogen in the presence of fibrin thus allows efficient activation on the fibrin clot , while no significant plasminogen activation by t-pa occurs in plasma . scu-pa has a high affinity for plasminogen ( km = 0.3 microm ) but a low catalytic rate constant ( kcat = 0.02 sec-1 ) .
C0015982
fibrin
C0032105
plasma