at glucose concentrations above 3.3 mm , cytoplasmic insulin mrna was increasingly transferred to fractions co-sedimenting with ribosomes , and relatively more of the ribosome-associated insulin mrna became membrane-associated , consistent with effects of glucose above 3.3 mm on both the initiation of insulin mrna and srp ( signal recognition particle ) -mediated transfer of cytosolic nascent preproinsulin to the endoplasmic reticulum .
C0010834
cytoplasmic
C0014239
endoplasmic reticulum