we propose that the sequence-dependent effect of mtx plus fura on l1210 cell viability results from mtx and mtx polyglutamate inhibition of dihydrofolate reductase , and consequently a trapping of intracellular folates as dihydrofolate polyglutamates that could increase the extent of fdump binding to thymidylate synthetase .
C0280603
mtx
C0025677
mtx