assuming that metabolic interaction in the arene oxide pathway resulting in accumulation of epoxide intermediates of antiepileptic drugs could be responsible for teratogenesis , the ratio of carbamazepine to carbamazepine-10 , 11-epoxide concentrations in serum was determined in adult patients with epilepsy who were treated with carbamazepine only and with different combinations of phenobarbitone , valproate , and/or phenytoin .
C0014544
epilepsy
C0031507
phenytoin