the comparative toxicity test was performed on male rats , which were topically treated with a volume of 0.25 g/kg of 0.12 % dexamethasone valerate ( dv-17 ) ointment as a test drug , and 0.1 % dexamethasone ( dex ) , 0.05 % fluocinonide ( faa ) , 0.025 % beclomethasone dipropionate ( bmd ) , 0.1 % hydrocortisone butyrate ( hb ) , 0.05 % clobetasol propionate ( cp ) and 0.12 % betamethasone valerate ( bmv ) ointments as an active control drug for 30 consecutive days to evaluate on the effects of following items : body weight changes , adrenal functions ( organ weight , histological changes of the cortex and serum contents of corticosterone ) , pathological changes of hypophysis and lymphatic systems ( thymus , mesenteric lymph nodes and spleen ) , and skin changes .
C0024235
lymphatic systems
C0229792
mesenteric lymph nodes