to determine if desethylamiodarone ( da ) , the principal metabolite of amiodarone , has antiarrhythmic activity , da was administered intravenously ( i.v . ) as a 5 mg/kg bolus followed by a 2-h infusion of 8 mg/kg/h to 12 dogs with 5-7-day-old myocardial infarction and reproducibly inducible sustained ventricular arrhythmias .
C0002598
amiodarone
C0003195
antiarrhythmic