we have previously demonstrated that the human insulin receptor , mutated in the atp-binding domain of the beta-subunit , is kinase-defective and fails to mediate multiple post-receptor actions of insulin in stably transfected chinese hamster ovary cells ( chou , c.-k. , dull , t. j. , russell , d. s. , gherzi , r. , lebwohl , d. , ullrich , a. , and rosen , o. m. ( 1987 ) j. biol . chem . 262 , 1842-1847 ) .
C1448132
human insulin receptor
C0031727
kinase