as a result of intraperitoneal injections in mice of crude glycosaminoglycans obtained from the urine of patients with systemic scleroderma , a fibrotic process similar to the intial changes of human scleroderma was frequently observed , especially in the skin and esophagus when the glycosaminoglycans contained a probable variant of heparan sulfate .
C0017973
glycosaminoglycans
C0019143
heparan sulfate