we have provided evidence that tumor necrosis factor alpha ( tnf-alpha ) enhances the proliferation and the state of activation of human thymocytes cultured with concanavalin a or interleukin 2 ( il-2 ) , as evidenced by an increase in the expression of the c-myc gene and the gene of the il-2 receptor ( alpha-chain , tac antigen ) and by the expression of tac antigen on the cell surface .
C0086418
human
C0021756
interleukin 2