pre-steady-state data , analyzed in the framework of the three-step model , show that for b. beta-trypsin , b. thrombin , h.u . kallikrein , and h. urokinase the acylation step ( k2 ) is rate limiting above ph 6 and the deacylation step ( k3 ) below ph 4 in the hydrolysis of zlysonp and of zalaonp in the presence of acetamidine or ethylamine .
C0022478
kallikrein
C0020291
hydrolysis