skin changes observed following treatment of littermates with dmba alone included the appearance of giant tumor cells , dyskeratotic cells , nuclear hyperchromatism , increased nucleocytoplasmic ratio , and pleomorphic nuclei and nucleoli . oss of desmosomes , increased tonofibrils , and defects in the basement membrane with epithelial projections into the dermis were also seen .
C0007610
nuclei
C0007609
nucleoli