isosorbide 2,5-dinitrate and its pharmacologically active metabolites , isosorbide 2-nitrate and isosorbide 5-nitrate , in plasma accumulated to the predicted steady-state after five consecutive oral doses of sustained-release tablets containing 40 mg isosorbide dinitrate at 12-h intervals and after five consecutive oral doses of reference standard-release tablets containing 20 mg at 6-h intervals to 12 subjects in a crossover study .
C0028125
nitrate
C0064079
isosorbide 5-nitrate