we interpret these data as suggesting that ( i ) given the specificity and doses of the steroids used the effect of progestins on alpha lactalbumin synthesis is directly via progesterone receptor occupancy , and not by competing with glucocorticoids for glucocorticoid receptors and ( ii ) given the shift to the left in the alpha-lactalbumin response ( half maximal less than 0.1 nm org2058 ) compared with receptor binding ( kd ( 37 degrees c ) greater than 1 nm ) , one possible model for such sensitivity is that of multiple , independent regulatory elements on the chromatin controlling alpha-lactalbumin gene expression , occupancy of any one of which by an activated progesterone receptor is sufficient to abrogate transcription .
C0017262
gene expression
C0040649
transcription