signal transduction by thyrotropin-releasing hormone ( trh ) and carbamylcholine ( cch ) in some cells is mediated by inositol lipid hydrolysis forming the second messengers , inositol 1,4,5-trisphosphate ( i-1,4,5-p3 ) and 1,2-diacylglycerol , and causing elevation of cytoplasmic free ca2+ concentration [ ( ca2+ ] i ) .
C0007634
cells
C0010834
cytoplasmic