pretreatment with a combination of agonist plus phorbol 12-myristate 13-acetate resulted in a greater decrease in [ 3h ] prazosin binding at 4 degrees than was observed when cells were pretreated with agonist alone , induced the conversion of about half of cell surface alpha 1-adrenergic receptors to a form exhibiting limited accessibility to epinephrine in short-time assays , and induced a shift of about half of alpha 1-adrenergic receptors from the plasma membrane fraction to a light vesicle fraction on sucrose density gradients .
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of