both , in e. coli k-12 ( nal-resistance ) and in v79 chinese hamster cells in culture ( hprt-deficiency ) , the frequencies of mutation induction by all chemicals were the same when plotted against the amount of o6-ethylguanine formed in dna , suggesting that this dna adduct can be used as a common dosimeter for the comparisons of the frequencies of gene mutations induced by ethylating agents in various mutagenicity assay systems .
C0012854
dna
C0242958
dna adduct