the harmful effects of such medical reversible bilateral ovariectomy , in particular the increased risks of coronary heart disease and osteoporosis , can in all likelihood be obviated by 'low-dose ' oestrogen replacement therapy ( ert ) , specifically 0.625 mg of conjugated equine oestrogens ( cee ) for 21 days in each 28-day treatment cycle , and such ert use will only negate to a relatively small extent the beneficial effect of such bilateral ovariectomy on breast cancer risk .
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