using the whole-cell variation of the patch-clamp technique , we have determined that retinoic acid , an active metabolite of natural vitamin a that possesses potent immunomodulating activity , reduces the k+ current in human t lymphocytes and natural killer cells in a dose-dependent manner : acute treatment with 5 x 10 ( -5 ) m caused over a 70 % reduction while concentrations less than 1 x 10 ( -5 ) m caused less than 30 % inhibition .
C0040845
retinoic acid
C0042839
vitamin a