the accumulation of cyclic adenosine 3',5'-monophosphate ( camp ) in guinea-pig macrophages exposed to the adenylate cyclase ( ac ) stimulators prostaglandin e1 ( pge1 ) and isoproterenol ( ip ) , was markedly enhanced by pretreatment of the cells with colchicine , vinblastine , and podophyllotoxin -- agents which prevent microtubule assembly .
C0007634
cells
C1156032
microtubule assembly