adult sprague-dawley rats ( n = 225 ) were inoculated intracerebrally with transplantable , methotrexate sensitive , osteogenic sarcoma cells and 3 days later randomized to receive either no treatment or methotrexate with or without blood-brain barrier disruption using intracarotid mannitol .
C0029463
osteogenic sarcoma
C0025677
methotrexate