depletion of histone h1 , changes in nucleosome repeat lengths , and extents of dna elongation were investigated in synchronized chinese hamster ( line cho ) cells using the general conditions of hydroxyurea treatment that appear to increase the frequency of gene amplification , i.e. , synchronized cultures of g1 cells were allowed to begin to enter s phase before treatment with hydroxyurea was effected to retard dna synthesis ( mariani , b.d . and schimke , r.t. ( 1984 ) j. biol . chem . 259 , 1901-1910 ) .
C0012854
dna
C0598312
dna synthesis