we summarize the data that support this hypothesis and discuss possible mechanisms for 1 ) the differences in sensitivity to ryanodine displayed by intact skeletal and cardiac muscle preparations vs. that of skinned cardiac cells and isolated sr membranes , 2 ) the ability of ryanodine to cause either an increase or a decrease in calcium accumulation by isolated skeletal muscle sr vesicles depending on experimental conditions , and 3 ) the positive inotropic effects produced by ryanodine in cardiac muscle preparations under certain experimental circumstances .
C0018787
cardiac
C0027061
cardiac muscle