a series of isobutyl methyl 2,6-dimethyl-4- ( x-substituted phenyl ) -1,4-dihydropyridine-3,5-dicarboxylates ( x = h , 2-no2 , 3-no2 , 3-cn , 3-meo , 4-f , 2-cf3 , 3-cf3 , and 4-cl ) related to and including nisoldipine ( x = 2-no2 ) has been synthesized , their solid-state structures determined by x-ray analysis ( x = h , 2-no2 , 3-no2 , 3-cn , 3-meo , and 4-f ) , and their pharmacologic activities determined , as the racemic compounds , against [ 3h ] nitrendipine binding and k+-depolarization-induced tension responses in intestinal smooth muscle as measures of ca2+ channel antagonist activity .
C0012315
dihydropyridine
C0028127
nitrendipine