we suggest that in the system of matched pairs of n- and a-type transformants analyzed in this study , expression of the transformed phenotype in fr ( tsa58 ) 57 ( a-type ) cells at the nonpermissive growth temperature is due to the preservation of a biologically active conformation of the mutant large t , allowing it to maintain its interaction with specific targets at the cellular chromatin .
C0007634
cellular
C0008546
chromatin