patients with ocular coloboma and its variants may exhibit notching of the iris , peripapillary staphylomas , crater-like excavation of the optic disc , funnel-shaped widening of the retrobulbar optic nerve , cup-shaped filling defects in the perioptic subarchnoid space , and concurrent anomalies of the face , skull , and brain .
C0870814
excavation of the optic disc
C0006104
brain