equimolar doses of chlorambucil and melphalan ( both 10 mg/kg ) were administered i.v . to anesthetized rats , and the plasma and brain concentrations of chlorambucil , its metabolites 3,4-dehydrochlorambucil and phenylacetic mustard , and melphalan were determined by high-performance liquid chromatography from 5 to 240 min thereafter .
C0006104
brain
C0086045
concentrations