three gene loci could be identified by mutants pleiotropically defective in many or all of the enzymes tested in ccr 1 mutants , derepression of isocitrate lyase , fructose-1,6-diphosphatase , adhii and possibly of the cytoplasmic mdh is prevented , whereas the mitochondrial tca-cycle enzymes , succinate dehydrogenase and malate dehydrogenase , are not significantly affected .
C0010834
cytoplasmic
C0026237
mitochondrial