an indirect mechanism appears to be responsible for the inhibition of transformed b-cell outgrowth in response to il-3 , as il-3 had no inhibitory effect on proliferation of pure transformed b-cell clones and il-3-mediated inhibition could be eliminated by antibody neutralization of gamma-interferon ( gamma-ifn ) or tumor necrosis factor-alpha ( tnf-alpha ) early in culture .
C0004561
b-cell
C1155008
proliferation