in the present studies , we demonstrate in buffer-perfused isolated working guinea pig hearts that indometacin reduces coronary flow rate in a dose-dependent manner ( max 56.7 +/- 5.5 % , sem , n = 6 , of control at 5 x 10 ( -6 ) mol/l of indometacin , p less than 0.01 ) , and that this leads to a development of heterogeneous patterns of myocardial ischemia ( elevated myocardial levels of reduced pyridine nucleotide , nadh ) and depressed cardiac work ( 64.7 +/- 11.7 % , sem , of control at 5 x 10 ( -6 ) mol/l of indometacin , p less than 0.05 ) .
C0027061
myocardial
C0018787
cardiac