the various forms of the prurigo nodes secondarily develop in case of the coincidence of three main factors : ( 1 ) the particular cutaneous response to repeated irritation ( especially in autosomally dominant ichthyosis simplex ) , ( 2 ) reduced threshold for or constitutional disposition to pruritus ( especially in atopy ) , and ( 3 ) internal ( e.g . intestinal disorders ) or external ( e.g . insect bites ) triggers .
C0037267
the
C0033774
pruritus