serial cytogenetic studies using banding techniques at various stages during the course of the disease ( preleukemia , leukemia , remission , and relapse ) showed several chromosomal abnormalities ( unbalanced translocation between chromosomes 1 and 4 leading to trisomy 1q , trisomy 7q , monosomy 7p , and a reciprocal translocation between chromosomes 10 and 16 ) .
C0008633
chromosomal
C1327882
1q