previous studies have suggested that 1- ( 4-amino-2-methylpyrimidine-5-yl ) -methyl-3- ( 2-chloroethyl ) -3-nitrosoureahydrochloride ( acnu ) and 1 , ( 2-chloroethyl ) -3-cyclohexyl-1-nitrosourea ( ccnu ) bind specifically to the nucleosomal dna of murine bone marrow and l1210 leukaemia cells whereas the glucose nitrosoureas , 2- ( 3- ( 2-chloroethyl ) -3-nitrosoureido ) -2-deoxy-d-glucopyranose , ( chlorozotocin , clz ) and 1- ( 2-chloroethyl ) -3- ( -d-glucopyranosyl ) -1-nitrosourea ( ganu ) , bind preferentially to the linker dna of bone marrow but not tumour cell chromatin .
C0028623
nucleosomal
C0008546
chromatin