four patients with profound reduction in serum c3 showed metabolic changes comparable to those seen in hypocomplementemic mesangiocapillary gn ( mcgn ) , that is , nonlinear plasma disappearance of 125i.c3 and a gross ( that is , 30-fold ) reduction in c3 synthesis ( 0.01 to 0.02 mg/kg/hr ) ;
C0229671
serum
C0032105
plasma