in serum-supplemented medium ( eagle 's minimum essential medium containing 2 % steroid-free fetal calf serum ) , testosterone or 5 alpha-dihydrotestosterone ( 10 ( -9 ) -10 ( -6 ) m ) significantly stimulated the growth of sc-3 cells ( 3.2-fold increase in cell number at day 10 in culture containing 10 ( -8 ) m androgens ) and changed the shape of sc-3 cells from epithelial to spindle ( fibroblast-like ) , whereas 17 beta-estradiol ( 10 ( -12 ) -10 ( -6 ) m ) even in high concentrations had no such effects on sc-3 cells .
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growth of
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