weber [ ( 1984 ) proc . natl . acad . sci . usa 81 , 7098-7102 ] has inferred that the monod-wyman-changeux ( mwc ) model for ligand binding by hemoglobin would require ( contrary to experimental evidence ) that increased ligand binding must promote stabilization of alpha 2 beta 2 tetramers with respect to dissociation into alpha beta dimers .
C1418943
proc
C1517880
ligand binding