in order to elucidate whether or not the 'coupling defect ' observed in thyroids from diabetic rats is due to a structural defect of intrathyroidal thyroglobulin ( tg ) , the sedimentation pattern and the stability of the thyroidal soluble iodoproteins were studied in control ( c ) , food restricted ( fr ) , diabetic ( d ) and insulin-treated diabetic ( d+i ) rats fed a low iodine diet either with ( nid ) or without ( lid ) iodide supplementation and labelled with 125i : acutely , 24 h prior to sacrifice and chronically , by feeding the corresponding diet labelled for 60 days .
C0040123
thyroglobulin
C0040132
thyroidal