in an open multi-centre study , 51 patients with mild to moderate hypertension were treated with either a single dose of 40 mg penbutolol per day for 8 weeks or changed over at 4 weeks due to inadequate response with penbutolol alone to a single dose ( 1 tablet ) of a fixed combination of 40 mg penbutolol and 20 mg furosemide per day for a further 4 weeks .
C0020538
hypertension
C0030812
penbutolol