since pgi2 is a vasodilator and the other 3 prostanoids ( pgf2 alpha ; pge2 ; txa2 ) are cerebral vasoconstrictors , these changes may be relevant to the pathogenesis of the previously reported abnormalities of cerebral blood flow and the increased incidence of cerebrovascular disease in dm .
C0033554
prostanoids
C0012472
pge2