given these results and the histochemical demonstration of an inhibition of compound 48/80-induced release of serotonin , it is suggested that : lodoxamide antagonizes the action of compound 48/80 by blocking the release of mast cell constituents , and neither compound 48/80 nor the released constituents appear to modify vascular responsiveness to arterenol or hypervolemia following the initiation of hypotension .
C0028351
arterenol
C0020649
hypotension