nerve growth factor ( ngf ) causes the differentiation of pc12 cells to sympathetic neuron-like cells and also induces a rapid but transient expression of fos mrna and protein . fos mrna transcripts can be detected 5 min after the addition of ngf , are maximally abundant after 30 min , and then their levels decrease . fos protein synthesis parallels the expression of fos mrna , and the induced fos proteins are located in the nucleus .
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the differentiation
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cells