cis and trans isomers of 1-amino-2- ( p-chlorophenyl ) cyclohexane , conformationally restricted analogs of p-chloroamphetamine , did not decrease brain serotonin and 5-hydroxyindoleacetic acid concentrations at i.p . doses of .05 and .1 mmole/kg in rats , doses at which p-chloroamphetamine itself decreased the concentrations of these 5-hydroxyindoles to half or less of their initial values .
C0006104
brain
C0086045
concentrations