in sprague-dawley rats , acronycine in the vehicle of 0.05 % polysorbate 80 in phosphate-buffered saline was carcinogenic , producing tumors of the mammary gland in females , osteosarcomas in males , and sarcomas and other related tumors of the peritoneum in both males and females .
C0029463
osteosarcomas
C1261473
sarcomas