these observations provided the evidence that aa urinary extracts contain a factor that directly stimulates megakaryocyte progenitor cell proliferation in mouse spleen in vivo as well as the release of platelets from megakaryocytes , and itp urinary extracts do not contain increased levels of meg-csf and/or some other factor that directly stimulates cfu-meg in vivo , and the decreased blood platelet mass that is clinically characteristic of itp is not a primary in vivo determinant of the elaboration of these factors .
C0392386
decreased blood platelet
C0398650
itp