this pattern was characterized as follows : ( 1 ) predominantly anti-tbe igg antibodies appeared earlier and in higher titres than in the control group , ( 2 ) heterologous hi antibodies cross-reacting with the wn flavivirus subgroup preceded the appearance of homologous hi antibodies , ( 3 ) a broad spectrum hi response was observed against all flaviviruses tested , and ( 4 ) low titre heterotypic den-2 neutralizing antibodies were formed in about half of the cases .
C0003241
antibodies
C0003248
heterotypic