three fibroblast strains with isolated catalytic defects in pp-rib-p synthetase showed milder increases in pp-rib-p concentration ( 2.5-fold normal ) and generation ( 1.6- to 2.1-fold ) and in rates of purine synthesis de novo ( 1.6- to 2.2-fold ) and purine nucleoside triphosphate pools ( 1.5-fold ) than did cells from 2 individuals with combined kinetic defects in pp-rib-p synthetase , both with purine nucleotide inhibitor-resistance .
C0016030
fibroblast
C0007634
cells