hydrolysis of membrane-associated phosphatidylinositol 4,5-bisphosphate ( ptdins ( 4,5 ) -p2 ) to water soluble inositol 1,4,5-trisphosphate ( ins ( 1,4,5 ) p3 ) is a common response by many different kinds of cells to a wide variety of external stimuli ( see refs 1 and 2 for review ) .
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hydrolysis
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refs 1