two main theories of pathophysiologic pathways have evolved : ( 1 ) the neurotraumatic , which states that the changes result from mechanical trauma and repetitive injuries to an insensitive extremity or joint and ( 2 ) the neurovascular , which states that the changes result from a neurally initiated vascular reflex that leads to hyperemia , angiogenesis , and very active bone resorption by osteoclasts .
C0005847
vascular
C0302600
angiogenesis