these findings support the proposition that in quinine- and quinidine-induced thrombocytopenia , drug and antibody combine first in the soluble phase to form a complex , which then binds with high affinity to a receptor on the platelet surface ( innocent bystander reaction ) , and demonstrate that these antibodies are heterogeneous in respect to the amount of drug required to promote their binding to platelets , the number of platelet receptors they recognize , and their binding affinities .
C0034417
quinine
C0040034
thrombocytopenia