the hypothesis is supported by ( 1 ) epidemiologic evidence that the risk of myocardial infarction increases markedly following hysterectomy whether or not the ovaries are removed , ( 2 ) evidence that premenopausal women may have higher circulating levels of prostacyclin than men of comparable ages , ( 3 ) production of prostacyclin by uterine tissue homogenates , ( 4 ) preliminary data showing high levels of prostacyclin 's stable end-product metabolite in the venous drainage of the uterus , and ( 5 ) plausible mechanisms through which prostacyclin could produce a salutary effect on coronary disease .
C0020699
hysterectomy
C0042149
uterine