use of this system ( nutrients plus mannitol minus 2,4-d ) for the study of cell senescence was explored both in batch culture and in a system designed to permit medium renewal without withdrawal of live cells.in both systems , an initial period ( 1-6 days ) of limited increase in cell number is characterized by a continuous decrease in the respiratory activity and in protein and rna synthesis to very low basal rates .
C0007581
cell senescence
C0007634
cells