to study the possible clinical significance of the appearance of insulin autoantibodies prior to the diagnosis of type 1 ( insulin-dependent ) diabetes , and their value in predicting the antibody response to exogenous insulin , we observed 46 newly diagnosed diabetic children and adolescents over the year following diagnosis for the occurrence and duration of clinical remission , daily insulin dose , metabolic control , residual b-cell function , insulin-binding antibodies and conventional as well as complement-fixing islet cell antibodies .
C0021641
insulin
C0022131
islet cell