although several oncogenes have been identified through the study of tumor-producing retroviruses in animals , discovery of the bcr/abl translocation , the altered 8.5 kb bcr/abl transcript , and the hybrid bcr/abl p210 protein with enhanced tyrosine kinase activity has provided one of the first examples of a human neoplasm in which structural alterations in a normal cellular gene might lead to malignant transformation .
C0029016
oncogenes
C0004891
bcr/abl