since dialysis of human factor viii against buffers of low ionic strength yielded two distinct components , and since the factor viii fraction isolated from normal plasma showed von willebrand factor activity as defined by the corrective effect on abnormal platelet retention and ristocetin aggregation in von willebrand 's disease , the present studies were performed to determine if the correcting activities could be attributed to one or both of the components .
C0015506
factor viii
C0042974
von willebrand 's disease