yac-1 lymphoma cells , both when cultured in vitro and when passaged in ascites form in vivo , synthesize gangliosides ( means of 22.1 and 14.7 nmol lipid-bound sialic acid isolated per 10 ( 8 ) cells , respectively ) with potent inhibitory effects on mitogen- and antigen-induced lymphoproliferation : 10 to 30 nmol highly purified yac-1 gangliosides/ml caused greater than 90 % inhibition of proliferative responses of murine lymphocytes to concanavalin a , lysozyme ( a soluble specific antigen ) , and allogeneic cells ( mixed-lymphocyte response ) .
C0007634
cells
C3485979
allogeneic cells