the ultrastructural examination of the skin lesions of 2 typical patients with subacute disseminated histiocytosis x 12 , 24 , 36 , 48 and 72 hours after the intravenous administration of vinblastine enabled us to observe that , after 12-24 hours , there were numerous langerhans cells undergoing mitosis which had no spindle microtubules but showed fragments of newly forming nuclear membrane , thus demonstrating that mitosis was arrested in anaphase .
C0019621
histiocytosis x
C0023005
langerhans cells