the following lines of evidence support an intermolecular mechanism for the activation of the detergent-solubilized receptor : the egf-induced receptor self-phosphorylation has a parabolic dependence on the concentration of egf receptor , cross-linking of egf receptors by antibodies or lectins stimulates receptor self-phosphorylation , immobilization of egf receptor on various solid matrices prevents egf from activating the kinase function , and cross-linking of egf receptors increases their affinity toward egf .
C0031715
phosphorylation
C0031727
kinase