in adult rats , the intracerebroventricular injection of alpha-difluoromethylornithine ( dfmo ) , a polyamine antimetabolite which specifically inhibits ornithine-decarboxylase , induces a typical convulsive syndrome ( ed50 = 100 micrograms/rat ) and death ( ld50 = 300 micrograms/rat ) .
C0002260
alpha-difluoromethylornithine
C0029282
ornithine-decarboxylase