obese ( db/db ) mice were studied at 5 wk of age , when they were rapidly gaining weight and were severely insulin resistant , evidenced by hyperglycemia ( plasma glucose 683 +/- 60 vs. 169 +/- 4 mg/dl in db/+ , p less than 0.05 ) and hyperinsulinemia ( plasma insulin 14.9 +/- 0.53 vs. 1.52 +/- 0.08 ng/ml in db/+ , p less than 0.05 ) .
C0021641
insulin
C0020456
hyperglycemia