hypophysectomy in young male wistar rats aged 70 days , followed by cortisone acetate replacement therapy throughout life , retarded the rate of aging of tail tendon collagen fibres , inhibited the development of certain diseases of old age ( renal disease , cardiac enlargement , hind limb paralysis , and various endocrine and non-endocrine tumors ) and significantly prolonged the duration of life .
C0020632
hypophysectomy
C0014136
endocrine