since pge2 and prostacyclin can affect the activity of immunocompetent cells and bone resorbing osteoclasts , our finding indicates that thrombin and bradykinin , both of which are formed in inflammatory processes as a consequence of activation of the hageman factor ( coagulation factor xii ) , may have important roles in the modulation of the inflammatory response and the loss of alveolar bone in periodontitis .
C0006100
bradykinin
C1155266
inflammatory response