population data analysed from two centres ( 43 infants from glasgow and 100 infants and children from manchester ) by the computer program nonmem showed that volume of distribution was related to body weight by a proportionality factor that decreased from the region of 0.41-0.46 l/kg in children less than 3 months to 0.25-0.32 l/kg in older children , a value which merges with that accepted for adults ( 0.25 l/kg ) .
C0008059
children
C1455726
older children