in 1980 , the french cooperative group on chronic lymphocytic leukemia started a randomized clinical trial in which intermediate prognosis patients ( stage b ) received either an indefinite course of chlorambucil ( 0.1 mg/kg/d ) or 12 cycles of the cop regimen ( vincristine , cyclophosphamide , and prednisone ) .
C0023434
chronic lymphocytic leukemia
C0010583
cyclophosphamide