reaction of this haemoglobin with anionic , cationic and non-ionic detergents , respectively , leads to a transformation of the no-ligated form into a `` '' relaxed '' '' conformation with a stretched or broken sigma bond of the 5th ligand ( nepsilon of imidazole ) and a strong sigma bond of the 6th ligand ( no ) .
C0007447
cationic
C0022023
ionic