to determine whether or not cholesterol sulfate accumulates in recessive x-linked ichthyosis as a direct result of the missing enzyme , steroid sulfatase , we quantitated both steroid sulfatase and its substrate , we quantitated both steroid sulfatase and its substrate , cholesterol sulfate , in different epidermal strata , as well as within stratum corneum subcellular fractions obtained from normal human and neonatal mouse epidermis and from patients with recessive x-linked ichthyosis .
C0014520
epidermal
C0221921
stratum corneum