in the following i discuss the possibility that alterations in the activity of norepinephrinergic neurons at the level of the locus coeruleus ( lc ) associated with dysregulation of descending endorphinergic projections from the arcuate nucleus of the hypothalamus may be intimately involved in the pathogenesis of motor fluctuations in l-dopa treated pd .
C0023570
l-dopa
C0030567
pd