the results indicate that in complete obstructive cholestasis ( a ) taurocholate continues to be taken up from blood by hepatocytes and secreted into bile , but in terms of varying duration of obstruction , ( b ) all acinar zones are involved in bile salt transport , ( c ) in the initial phase ( 4 h and 4 days respectively after bile duct obstruction ) hepatocytes fail to concentrate taurocholate at the canalicular site , ( d ) in a consecutive phase , in which bile ductules and ducts proliferate ( demonstrated for a 15-day cholestasis ) , the taurocholate concentration at the canalicular site of hepatocytes is re-established and biliary secretion seems to be enhanced , ( e ) the biliary epithelium of bile ductules and ducts may play a significant role in the reabsorption and/or regurgitation of bile salts from bile to blood .
C0005404
bile salts
C0005388
bile