to determine whether pharmacological control of blood pressure could affect the renal function and levels of atrial natriuretic polypeptide ( anp ) in spontaneously hypertensive rats ( shr ) with renal ablation , and to ascertain the benefits of antihypertensive drugs , we studied effects of oral administration of captopril ( 50 mg/kg/day ) , an inhibitor of angiotensin converting enzyme , benidipine ( 3 mg/kg/day ) and nilvadipine ( 10 mg/kg/day ) , newly developed blockers of calcium channel , and indapamide ( 10 mg/kg/day ) for 14 days on systolic blood pressure , serum creatinine , blood urea nitrogen , and plasma anp concentration in shr subjected to surgical removal of the left kidney and infarction of two-thirds of the right kidney ( 5/6 nephrectomy ) a week before .
C0022646
renal
C0027695
nephrectomy