it appears that the high affinity enzyme is a polycyclic aromatic hydrocarbon-inducible isozyme of cytochrome p-450 , based on competitive inhibition by 7-ethoxyresorufin and benzo [ a ] pyrene , and based on a significant ( p less than 0.001 ) correlation between 7-ethoxyresorufin-o-deethylation and methylxanthine demethylation rates . alpha-naphthoflavone inhibited all methylxanthine demethylations in excess of 80 % in two high activity livers , whereas 8-hydroxylations were generally inhibited less .
C0014442
enzyme
C0022173
isozyme