to test the hypothesis that adenosine is the primary mediator of hypoxia-induced atrioventricular conduction delay in isolated perfused guinea pig hearts , we characterized a ) the time courses of hypoxia-induced adenosine release and delay in atrioventricular conduction , b ) the relationships between oxygen tension , adenosine concentration in the effluent , and atria-to-his-bundle interval , and c ) the adenosine receptor mediating the negative dromotropic effect of hypoxia .
C0018787
hearts
C0006382
his-bundle