treatment of animals with the biguanide drug metformin ( n ' , n'-dimethylbiguanide ) decreased the ability of glucagon to stimulate this enzyme to some 16-fold for both the lean and obese animals and reduced the ka values for activation of this enzyme by glucagon to 6.3 and 60.9 nmol/l respectively .
C0005382
biguanide
C0025598
metformin