teratogenic doses of antimalaria preparation , 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine ( chloridine ) , known in biochemistry as a specific inhibitor of dihydrofolate reductase , result in the decrease of 32p-phosphate incorporation into atp and adp , coupled with the inhibitions of dna synthesis , in rat embryo and placenta on 13th day of development , while the incorporation of 14c-formiate into free nucleotides of acid soluble embryo and placenta fractions ( at the same intervals after teratogen injections ) , is the same as in the control .
C0032058
placenta
C0032043
placenta