to estimate the relative contributions of gluconeogenesis and glycogenolysis to the increase in hepatic glucose output ( hgo ) during glucose counterregulation under conditions simulating clinical insulin hypoglycemia , we induced moderate hypoglycemia ( approximately 55 mg/dl ) with a continuous infusion of insulin that resulted in physiological hyperinsulinemia ( approximately 20 microu/ml ) in eight normal volunteers and estimated gluconeogenesis by two methods : an isotopic approach in which appearance of plasma glucose derived from lactate was determined and another approach in which we infused alcohol along with insulin to block gluconeogenesis and used the exogenous glucose required to prevent greater hypoglycemia as an index of gluconeogenesis .
C0017725
glucose
C0020615
hypoglycemia