there is no doubt that hla-dr molecules are acting as the products of hla-linked immune response genes ( ir-genes ) , because ( i ) hla-dr molecules are the restriction elements in the interaction between cd4+ helper t cells and antigen-presenting cells ( apc ) to respond to many antigens such as streptococcal cell wall antigen ( scw ) ( nishimura & sasazuki , 1983 ; sone et al. , 1985 ; hizayama et al. , 1986 ) , schistosomal antigen ( sj ) ( hirayama et al. , 1987 ) , mycobacterium leprae antigen ( ml ) ( kikuchi et al. , 1986 ) and so on ;
C0301872
immune response
C0019764
hla-dr