since , on the one hand , the hypothyroidism-induced abnormalities in renal medulla responsiveness to vasopressin were reversible and , on the other , only a permanent therapy consisting of two daily physiological doses of thyroxine from birth to the age of sacrifice fully restored them , the responsiveness of developing kidney to thyroid hormones appears to be fundamentally different from that of the cns .
C0020676
hypothyroidism
C0040165
thyroxine