all the gamma-monoamides were tested as inhibitors of purified dihydrofolate reductase ( dhfr ) from murine l1210 leukemia cells and as inhibitors of the growth of wild-type l1210 cells and a subline ( l1210/r81 ) with high-level resistance to mtx and amt based mainly on a defect in drug uptake via active transport .
C0025677
mtx
C0002583
amt