the view that the cytochalasin-induced changes in insulin release are due to a primary biophysical effect on microfilaments , rather than to an unrelated biochemical alteration of the beta-cell glucose-sensor device , was strengthened by the following observations : ( 1 ) the onset and disappearance of the cytochalasin b-induced facilitating action upon insulin release followed a time-course parallel to that characterizing the ultrastructural changes provoked by the drug in the distribution of beta-cell microfilamentous material ;
C0007634
cell
C0025979
microfilamentous