although the possibility can not be excluded that suppression is due to the stabilisation or activation of the mutant enzyme by some indirect effect of the suppressor ribosomal mutations , the following working hypothesis is favoured at the moment : it is assumed that limitation of the aminoacyl-trna synthetase activity in a certain range of the restrictive temperature causes growth inhibition by the premature termination of polypeptide synthesis at the ribosome or by the unbalanced synthesis of the individual cellular proteins under this condition .
C0035553
ribosome
C0007634
cellular