we , therefore , assessed the pharmacokinetic and pharmacodynamic characteristics of intravenously administered furosemide and bumetanide in ten adult patients with stable , chronic renal insufficiency ( mean creatinine clearance = 14.1 +/- 2.0 ml/min/1.73 m2 ) in a randomized , cross-over study during controlled sodium intake .
C0006376
bumetanide
C0022661
chronic renal insufficiency