the synthesis of poly-gamma-glutamyl derivatives of 7-hydroxymethotrexate ( 7-oh-4-nh2-10-ch3-pteroyl-glutamic acid ( pteglu1 ] was evaluated by direct hydroxylation of the tetraglutamyl derivative of methotrexate ( 4-nh2-10-ch3-pteglu4 ) by a cell-free preparation of rabbit liver aldehyde oxidase and by polyglutamylation of 7-oh-methotrexate in ehrlich ascites tumor cells in vitro .
C0016410
pteroyl-glutamic acid
C0025677
methotrexate