when stimulated with pokeweed mitogen ( pwm ) , phytohemagglutinin ( pha ) , or the tumor-promoting agent , phorbol tetradecanoyl-acetate ( tpa ) , the cll cells proliferated actively by day 3 or 4 of culture , and in four cases , differentiated to significant numbers of immunoglobulin-containing cells .
C0007634
cells
C0007589
differentiated