to differentiate beta 1- and beta 2-adrenoceptor-mediated effects in humans , we studied the effects of a 2-wk treatment of 12 male volunteers with the selective beta 1-adrenoceptor antagonist bisoprolol ( 1 x 10 mg/day ) and the beta 2-selective antagonist ici 118,551 ( 3 x 25 mg/day ) on lymphocyte beta 2-adrenoceptor density and responsiveness [ 10 microm l-isoproterenol ( ipn ) evoked adenosine 3',5'-cyclic monophosphate ( camp ) increase ] as well as on exercise- and ipn-induced changes in lymphocyte beta 2-adrenoceptor density , blood pressure , heart rate , and plasma norepinephrine levels .
C0086418
humans
C0001643
beta 2-adrenoceptor