the in vivo administration of the antimetastatic drugs icrf159 and dm-cook , or of the cytotoxic drugs cyclophosphamide , cisplatin , ccnu and ganu , does not cause a pattern of enzyme inhibition matching the tumor metastatic potential and the increase in life-span of the treated tumor bearing mice , indicating that the inhibition of cathepsin b-like cysteine proteinase is not involved in either their cytotoxic or their antimetastatic action .
C0699919
cathepsin
C2717970
cysteine proteinase