on the other hand , blocking of anti-tcr/cd3 mab-induced ctl reactivity by anti-cd4/cd8 mabs does not necessarily involve an interference with the binding of cd4 and cd8 to their respective ligands and it has been proposed that the tcr and cd4 or cd8 form functional complexes that are required for optimal t-cell activation .
C0034790
tcr
C1155065
t-cell activation