for the purpose of studying the pharmacokinetic profile of sisomicin ( siso ) and the proper conditions for its administration to children , siso was administered intramuscularly to 10 infants aged less than 1 year , 16 young children and 18 school children at doses of 1.0 , 1.5 and 2.0 mg/kg and its serum and urine levels were determined by bioassay .
C0008059
children
C0021270
infants