it was found : ( 1 ) the tumour grows at the same rate with the same median survival time in matched groups of non-immunized mice from both strains after i.p . injection of tumour cells . ( 2 ) cyclophosphamide ( cyclo ) at 10 mg/kg will cure cba mice which have received i.p . injections of 10 ( 7 ) bp8 , but this dose , and more intensive treatment with this drug , fails to cure c3h mice . ( 3 ) injecting ( 125 ) iudr-labelled tumour cells and counting ( 125 ) i loss by whole-mouse counting shows that the cytotoxic effect of cyclo against bp8 is similar in the 2 mouse strains . ( 4 ) cyclo itself does not cure cba mice , for viable tumour cells are recoverable from the peritoneal cavity 10 days after cba mice have received 10 ( 7 ) bp8 followed by 10 mg/kg cyclo . ( 5 ) cba mice cured of bp8 ascites by cyclo treatment will reject further i.p . inocula of bp8 . ( 6 ) the strength of immunity induced by irradiated bp8 cells was directly related to the length of exposure to this antigen .
C0020964
immunity
C0003320
antigen