two sporadic cases of striato-nigral degeneration were characterized by the onset at the age of 61 of an akinetic-hypertonic syndrome and of a minimal or absent rest tremor , with a pyramidal syndrome , sphincter disorders , dysphonia , difficulty in swallowing and an unfavorable development in the space of two or three years not affected by l-dopa .
C0039082
syndrome
C0012634
disorders