histomorphometry and electron microscopy ( tibiae ) , aluminum tissue ( bone , kidney , liver ) determination , serum ( ca , mg , zn , p , urea , creatinine , alkaline phosphatase , 1,25 ( oh ) 2d3 , pth ) and urine ( creatinine , a1 ) revealed that : ( a ) a dose of 8.4 mg aluminum was sufficient to induce rickets within 4 weeks of treatment and was associated with decreased serum calcitriol values and high aluminum accumulation within organs ( electron-dense material was found in osteoblasts only ) ;
C0035579
rickets
C0006674
calcitriol