despite an abundance of evidence that presynaptic alpha 2-adrenergic receptors mediate inhibitory control of the release of norepinephrine ( ne ) from the terminals of locus coeruleus ( lc ) neurons , few studies have demonstrated the physiological significance of this `` '' autoreceptor '' '' -mediated inhibition on ne-mediated synaptic activity within the mammalian brain .
C3274768
inhibitory control
C0027882
neurons