among 562 patients with histologic stage b-1 , b-2 , or c adenocarcinoma of the prostate treated by radical prostatectomy and pelvic lymphadenectomy , analysis revealed that increasing histologic stage , tumor size , degree of capsular invasion , seminal vesicle involvement , and histologic grade all were highly correlated with both local and systemic progression ( log-rank two-sided p less than or equal to 0.0001 ) .
C0194810
radical prostatectomy
C0036628
seminal vesicle