it is postulated that the basic defect in cf is due to the deficiency of an enzyme that cleaves the arg-asp peptide bond in cholecystokinin to produce the active octapeptide cck-8 , which normally stimulates exocrine secretion , especially in pancreas , gallbladder , and intestine , and potentiates the action of other gastrointestinal hormones .
C0008328
cholecystokinin
C0037167
cck-8