to determine the mechanism by which pancreatic extract ( pe ) corrects the malabsorption of vitamin b12 in chronic pancreatic insufficiency ( cpi ) , the following hypotheses were investigated : firstly , pe might stimulate the absorption of vitamin b12 by changing the intestinal ph , secondly pe might stimulate the intestinal uptake of unbound vitamin b12 , thirdly pe might abolish the inhibitory effect of vitamin b12 binders on the intestinal uptake of vitamin b12 bound to intrinsic factor ( if ) .
C0024523
malabsorption
C0021853
intestinal