the failure to detect unreplicated dpn i-sensitive plasmid concatemers early in replication together with the absence of significant levels of integrated plasmid sequences in the poxviral genome suggest that replication of the transfected plasmid dna is not the consequence of nonhomologous recombination of concatemeric plasmid dna into the poxvirus genome , but rather of an autonomous process that is dependent on trans-acting replication factors produced during virus infection , and that does not require a specific origin sequence on the substrate plasmid dna .
C0012854
dna
C0000702
a