the paradoxical increase in activity of the normally n-ethylmaleimide-sensitive cathepsins apparently occurred as the result of the protective compartmentalization of the cathepsins in the lysosomes ( 20,000 x g sedimented fraction ) and the unprotected localization of an inhibitor ( s ) in the soluble cytoplasm ( 175,000 x g supernatant fraction ) .
C0024369
lysosomes
C0010834
cytoplasm