castanospermine , an indolizidine alkaloid isolated from the seeds of the chestnut tree castanospermum australe , has been shown to prevent the normal glycosylational processing of the v-fms-transforming glycoprotein . v-fms-transformed cells grown in vitro in the presence of castanospermine accumulate immature forms of the glycoprotein that do not reach the cell surface .
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