a single sublethal dose of pd-109-hematoporphyrin ( up to 36 muci/kg ) resulted in the following : predominant concentration in lymphoid tissue and proximal bone marrow , complete central and proximal bone marrow ablation with preservation of distal bone marrow , massive depletion of lymphocytes from lymph nodes and spleen , an 80 % reduction in peripheral blood lymphocytes which was completed by the addition of als , full recovery of lymphoid tissue and blood cellularity within 60 days of administration of radionuclide , and a 100 % animal survival rate .
C1518997
peripheral blood lymphocytes
C0024296
lymphoid tissue