because of their central role in host defense ( in inflammatory responses , in antigen presentation , and in immunoregulatory networks ) , monocyte/macrophage dysfunction may result in one or more pathophysiologic consequences : defects in monocyte maturation , deficiencies in the clearance of physiologic substrates in lysosomal diseases ( e.g. , gaucher 's disease , mucopolysaccharidoses , osteopetrosis , metachromatic leukodystrophy ) , decreased synthesis and secretion of mediators ( complement component deficiencies ) , defects in microbicidal activity ( chronic granulomatous disease ) and defects which are acquired following infection and during chemotherapy ( e.g. , acquired immune deficiency syndrome ) .
C0520990
host defense
C1155266
inflammatory responses