a comparative , double-blind , placebo-controlled , double-dummy , randomized , crossover trial was performed in 32 hypertensive patients ( initial blood pressure [ bp ] 165/105 +/- 3/2 mm hg ) , most of them obese women , to evaluate the antihypertensive efficacy and tolerability of the new calcium channel blocking drug nisoldipine , 10 mg once or twice daily , over 6 weeks compared with the diuretic hydrochlorothiazide-amiloride ( hydrochlorothiazide , 25 mg , in combination with amiloride , 2.5 mg once or twice daily ) .
C0717400
hydrochlorothiazide-amiloride
C0020261
hydrochlorothiazide