while the kinetic parameters of beef liver ( cytoplasmic ) or heart ( mitochondrial ) aconitases did not vary over the ph range 4.9-9 with the natural substrates , and only slightly with the alpha-methyl substrates , the yeast aconitase exhibited a bell-shaped ph profile with all substrates and for binding of the competitive inhibitor , tricarballylate , with pk values around 7 and 9 .
C0010834
cytoplasmic
C0026237
mitochondrial