in three estrogen receptor-positive , estrogen-responsive breast cancer cell lines ( mcf-7 , zr75-1 , and t47d ) , type i sr blockade with alpha-ir3 failed to block estrogen-stimulated dna synthesis or cell proliferation , indicating that secreted igf activity is not the sole mediator of the growth effects of estrogen .
C0596290
cell proliferation
C0018270
growth