we conclude that in the in vitro generation of virus-specific ctl activity in bulk cultures of human pbl the sole function of t4+ cells in human virus-specific ctl generation is the production of il-2 , no cognitive cell interaction of t8+ ctl precursors with t4+ cells is required , and in bulk cultures t8+ cells themselves are not able to produce sufficient amounts of il-2 to ascertain the maturation of virus-specific ctl precursors into cytolytic t cells .
C0086418
human
C0021756
il-2