inasmuch as agonist-induced desensitization results in translocation of adrenoceptors from the plasma membrane to an intracellular vesicular fraction , we determined the intracellular distribution of cardiac adrenoceptors in two groups : group 1 ( n = 9 ) consisted of papillary muscles from patients with mild-to-moderate heart failure undergoing valve replacement , and group 2 ( n = 8 ) consisted of severely failing hearts removed during orthotopic cardiac transplantation .
C0018787
hearts
C0018823
cardiac transplantation