following intraperitoneal administration , the selective camp phosphodiesterase ( pde ) inhibitors rolipram , ici 63 197 and ro 20-1724 were investigated in mice in comparison with imipramine for their effectiveness in two classical test models for prediction of clinical antidepressant activity : antagonism of reserpine-induced hypothermia or hypokinesia and potentiation of yohimbine lethality .
C0035179
reserpine
C0724441
lethality