the depolarizing drug was applied to narrow strips of muscle in a rapidly flowing solution containing relatively impermeant anions rather than chloride.2 during prolonged applications of carbachol ( 10 to 20 mum ) , the depolarization caused by the drug showed a gradual decline which was attributed to desensitization.3 desensitization was little if at all affected by supplementing the external solution with factors present in tissue-culture media , or by treating the muscle with strophanthidin ( 25 mum ) .4 the rate of repolarization in the presence of carbachol ( 10 to 20 mum ) was greatly increased by the skf-525a congeners pipenzolate bromide ( 10 mum ) and adiphenine hydrochloride ( 1 mum ) .
C0003075
anions
C0008203
chloride