as demonstrated in binding experiments , and in classical pharmacological studies using rats , guinea pigs , cats , and dogs , bisoprolol markedly differentiated between beta 1-adrenoceptors of the heart , or the renal juxtaglomerular apparatus , and the beta 2-subtype in arterial blood vessels , bronchi , liver , or skeletal muscle .
C0022646
renal
C0022445
juxtaglomerular apparatus