given that recent data suggest that the cd44 molecule may bind to specific ligands on endothelial cells ( vascular addressin ) and within the extracellular matrix ( collagen , fibronectin ) , these data raise the possibility that binding of t cells to endothelial cells or extracellular matrix proteins may induce or up-regulate t cell activation in inflammatory sites .
C0015350
extracellular matrix
C0009325
collagen