conventional thrombolytic agents produce a systemic lytic state with the possibility of hemorrhage , therefore recombinant tissuetype plasminogen activator ( rt-pa ) and two other drugs , acylated streptokinase and pro-urokinase , were developed with the aim of inducing coronary thrombolysis without severe systemic lytic state , but the efficacy of these new drugs remains to be demonstrated in randomized trials versus conventional thrombolytic agents .
C0019080
hemorrhage
C0038418
streptokinase