heating of blood plasma acidified to ph 3.0 for 15-20 min at 61 degrees c allows for the conditions under which the kallikrein inhibitors ( alpha 1-antitrypsin , alpha 2-macroglobulin ) are destroyed whereas kallikrein , prekallikrein , low- and high-molecular kininogens ( hmk ) are preserved , thus constituting a complex of proteins making the kininogenase reaction feasible .
C0033024
prekallikrein
C0022478
kininogenase