the blockade of histamine receptors by repeated i.p . administration of 10-20 mg/kg of chloropyramine and tripelennamine , the potent h1-receptor antagonists , or by the i.c.v . administration of 2 mg/kg of metiamide and cimetidine , the highly selective h2-receptor antagonists , led to significant enhancement in the hypothalamic hd2 ( l-histidine carboxylase ;
C0008783
cimetidine
C2757005
h2-receptor antagonists