despite similar dna binding characteristics ( determined by flow cytometry ) of ho33342 in normal and at transformed fibroblasts , the at cells show : ( i ) enhanced cell killing and increased accumulation of cells in g2 phase of the cell-cycle [ both biological responses being relatively resistant in at cells to modification by an inhibitor of poly ( adp ribosyl ) ation ] , ( ii ) no resistance of de novo dna synthesis to ho33342-induced inhibition , ( iii ) elevated levels of slow-rejoining ligand-induced dna strand-breaks , and ( iv ) enhanced expression of chromatin regions accessible to an exogenously supplied endonuclease .
C0007634
cells
C0008546
chromatin