in order to further evaluate the effect of the nitroxyl moiety on the anticancer activity of nitroxyl labeled analogues of phosphoric n , n ; n ' , n ' ; n '' '' , n '' '' -tris [ 1,2-ethanediyl ] triamide ( tepa ) and phosphorothioic n , n ; n ' , n ' ; n '' '' , n '' '' -tris [ 1,2-ethanediyl ] triamide ( thio-tepa ) , the activity of these compounds was compared in vivo , using murine lymphoid leukemia l1210 , with the reduced forms of the drugs , i.e . the hydroxylamines and amine congeners .
C0020363
the hydroxylam
C0002508
and a