by employing a topoisomerase ii mediated dna religation assay [ osheroff , n. & zechiedrich , e.l. ( 1987 ) biochemistry 26 , 4303-4309 ] , etoposide was found to stabilize the enzyme-dna cleavage complex ( at least in part ) by inhibiting the enzyme 's ability to religate cleaved dna .
C0026741
enzyme
C0014442
enzyme 's