with increasing drug resistance cellular drug accumulation capacity ( as measured for doxorubicin ) progressively decreased , initial drug efflux rates ( as measured for daunorubicin ) progressively increased , while the subcellular doxorubicin distribution ( as measured by fluorescence microscopy ) gradually shifted from a `` '' mainly nuclear '' '' to a `` '' mainly cytoplasmic '' '' pattern .
C0011015
daunorubicin
C0013089
doxorubicin