additional experiments indicated that the anti-coagulant activity of the polysaccharides probably plays a minor role in their anti-metastatic effects since heparin , almost completely depleted ( 98-99.5 % ) of heparin molecules with anti-coagulant activity by passage over an anti-thrombin iii column , retained its ability to inhibit 13762 mat heparanases and was almost as effective as unfractionated heparin at inhibiting tumour-cell metastasis .
C0062505
mat
C1367469
heparanases