17 patients with refractory obesity , who had gained an average of 0.7 +/- 1.9 kg during 12 weeks treatment with diet and placebo , lost a mean of 2.9 +/- 0.5 kg after 12 weeks sequential treatment with dexfenfluramine 15 mg twice daily ( p less than 0.001 ) .
C0028754
obesity
C0011786
dexfenfluramine