this nick translation assay , originally proposed by nose and okamoto [ 1983 ] , is very sensitive , allows detection and quantitation of both dna damage and repair , distinguishes between various types of induced damage , does not require radioactive prelabeling of cells , and circumvents some of the problems inherent in unscheduled dna synthesis ( uds ) assays .
C0012860
dna damage
C0012899
unscheduled dna synthesis