because forskolin , a specific activator of adenylate cyclase , mimicked the actions of pge2 and pgi2 , i.e . inhibition of the antigen-induced plasma extravasation and enhancement of the histamine response , it is possible that the observed antiallergic effects of the prostaglandins were related to accumulation of intracellular adenosine 3 ' : 5'-cyclic monophosphate ( cyclic amp ) .
C0012472
pge2
C0033554
prostaglandins