local injections of kainic acid , which destroyed cholinergic and gaba neurons in the caudatoputamen and in the nucleus accumbens , caused a rapid ( 70-90 % ) decrease in the soluble guanylate cyclase and a slower 50-60 % fall in the particulate guanylate cyclase in these nuclei .
C1097411
soluble guanylate cyclase
C0018358
guanylate cyclase