with these techniques , specific constitutional chromosomal deletions or translocations have been discovered in inherited cases of retinoblastoma ( del.13q14 ) , wilms ' tumour with aniridia ( del.11p13 ) and renal-cell carcinoma ( t ( 3:8 ) ( p21 : q24 ) ) , in which each of the chromosomal changes appears to be a dominant factor in inheriting a predisposition to a tissue-specific tumour .
C1520361
11p13
C0008633
chromosomal