the resultant inhibition of acetyl-coa carboxylase by medica 16 and its coa thioester , together with the previously reported citrate-competitive inhibition of atp-citrate lyase by medica 16 , may account for the observed hypolipidemic effect of medica 16 under dietary conditions where liver lipogenesis constitutes a major flux of liver lipid synthesis .
C0023895
conditions
C0023884
liver