to evaluate whether the gamma-aminobutyric acid ( gaba ) ergic system plays a role in the defective insulin secretion in human diabetes mellitus , 15 non-insulin-dependent diabetics with fasting hyperglycemia above 140 mg/dl were submitted to two consecutive i.v . glucose tolerance tests ( ivgtt ) ( 0.33 g/kg b.w . ) , in basal conditions and after pharmacologic activation of the gaba system with baclofen and sodium valproate .
C0016904
gaba
C0004609
baclofen