ovariectomized rhesus monkeys bearing hypothalamic lesions which had abolished endogenous lhrh production , as evidenced by a profound reduction in gonadotropin secretion , but in which lh and fsh secretion was reestablished by a chronic intermittent iv infusion of synthetic lhrh ( 1 microgram/min for 6 min every hour ) were used to investigate the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion .
C0020663
hypothalamic
C0023610
lhrh