data from normal glands , graves ' goiters , non toxic multinodular goiters and nodular and perinodular tissue of toxic nodular goiters show the same basal , tsh- and naf- stimulated adenylate cyclase activities ( no . = 45 ; 34.1 +/- 3.2 ( m +/- se ) , 378 +/- 43 , 298 +/- 48 pmol camp x min-1 x mg membrane protein-1 ) , the same stimulability of ac by tsh ( 11.3 +/- 1.4 -- fold over basal level ) and by naf ( 8.1 +/- 1.8-fold ) , the same apparent tsh binding equilibrium constants ( 5.6 +/- 0.7 and 406 +/- 57 nm ) and the same tsh binding site concentrations ( 2.2 +/- 0.4 , 27.8 +/- 5.9 pmol x mg membrane protein-1 ) .
C0018021
goiters
C0342127
toxic nodular goiters