as pma is known to prevent the phenylephrine-induced increase in cytoplasmic free ca2+ concentration ( [ ca2+ ] c ) and to diminish the increase [ ca2+ ] c caused by glucagon , while having no effect on the ability of vasopressin to increase [ ca2+ ] c , these data are consistent with the notion that in intact cells an increase in [ ca2+ ] c results in an increase in the mitochondrial free ca2+ concentration , which in turn leads to the activation of pdh .
C0010834
cytoplasmic
C0026237
mitochondrial