progression to a reproductively non-viable late post-exponential state resulted in a continued parallel fall in nuclear size , increased cytoplasmic blebbing , further mitochondrial condensation , an increased proportion of cytoplasmic vacuoles containing osmiophilic material , the major part of which was melanin , and further clumping and margination of chromatin .
C0010834
cytoplasmic
C0042219
vacuoles