inducer-mediated differentiation of mel ( ds19 ) cells is a multistep process characterized by a latent period during which a number of changes occur including alterations in ion flux , an increase in membrane-bound protein kinase c ( pkc ) activity , the appearance of ca2+ and phospholipid-independent pkc activity in the cytosol , and modulation in expression of a number of genes such as c-myc , c-myb , c-fos and the p53 genes .
C0007634
cells
C1383501
cytosol