in 11 of 19 ( 58 % ) patients taking tmp 200 mg twice daily , tmp-resistant organisms emerged or increased during therapy ( p less than 0.01 , compared with none of the 12 controls ) , whereas in only 4 of 18 ( 22 % ) patients on smx-tmp did tmp-resistant organisms increase .
C0041044
smx-tmp
C0041041
tmp