in conclusion , cyclosporine a interferes with t-cell activation by human epidermis through at least two mechanisms : 1 ) in uninvolved skin , rapid inhibition of langerhans cell-mediated activation of t cells , and 2 ) in lesional skin , delayed inhibition of antigen-presenting activity which appears to correlate with the time course and level of reductions in non-langerhans cell dr+ leukocytes .
C0014520
epidermis
C0023005
langerhans cell