the method uses the synthetic metalloporphyrin cobalt-heme ( cobalt protoporphyrin ix ) , which possesses the dual biological properties of repressing delta-aminolevulinate synthase , the rate-limiting enzyme of heme biosynthesis , and of potently inducing microsomal heme oxygenase , the rate-limiting enzyme of heme catabolism .
C0025541
metalloporphyrin
C0018966
heme