enzymically activated nitrofurazone reacts with co-valently closed circular dna ( derived from escherichia coli minicells carrying lambdadv ) to give at least two kinds of damage : breaks which are detected on neutral sucrose gradients and alkali-labile lesions in dna which are converted to breaks when the dna is subsequently treated with alkali .
C0012925
circular dna
C0012854
dna