the following observations offer support for the hypothesis that the replication point is a weak point in the chromosome : ( 1 ) when conditions were created to obtain partially labeled chromosomes with replication points : ( a ) labeled markers appeared at the hybrid density , ( b ) unlabeled markers appeared at the light density , ( c ) shearing of the dna had little effect on the cscl density gradient , except on a small proportion of labeled markers which had not appeared at the hybrid density prior to shearing ;
C0598312
replication
C0012854
dna