further , since unsaturated somatomedin carrier proteins can interfere with the assay and in vitro biologic actions of the igfs , and since there was more unsaturated carrier protein binding of igf-1 by the sera of 15 children with renal disease v 15 normal children ( 17 +/- 3 % v 12 +/- 3 % binding of [ 125i ] -igf-1/50 mul serum , p less than .05 ) , we suggest that somatomedin carrier proteins should be evaluated for their role in the growth failure of children with chronic renal failure .
C0022658
renal disease
C0022661
chronic renal failure