in view of the high degree of qualitative correlation between mutagenic activity of chemicals in bacteria and in cultured mammalian cells , and their mutagenic and carcinogenic properties in animals , and in order to be able to distinguish whether mutagenic potency differences were due to differences in ( dna ) dose rather than other physiological factors , the results of mutagenicity tests obtained in the present experiments using bacteria and mammalian cells were compared on the basis of dna dose rather than exposure concentrations , with the following questions in mind : is there an absolute or a relative correlation between the mutagenic potencies of various ethylating agents in bacteria ( e. coli k12 ) and in mammalian cells ( v79 chinese hamster ) after treatment in standardized experiments , and can specific dna adducts be made responsible for mutagenicity ?
C0012854
dna
C0242958
dna adducts