we show that the decrease of guanine nucleotides is essential for the initiation of meiosis and sporulation : when a gua auxotroph , also lacking one of the two sam synthetases , is starved for guanine but supplemented with 0.1 mm methionine , gtp decreases while sam slightly increases and yet the cells sporulate .
C0018328
guanine nucleotides
C0018353
gtp