extractable ala synthase activity increases 2.5-fold within 6 hours after administration of 100 millimolar ethanol , a stimulator of mitochondrial development , and 4.5-fold within 12 hours after administration of 1 millimolar 4,6-dioxoheptanoic acid , which blocks ala utilization , suggesting that activity is controlled in vivo by a feedback induction-repression mechanism , coupled with rapid enzyme turnover.in heterotrophically grown wild-type cells , low levels of ala synthase rapidly increase 4.5-fold within 12 hours after cells are transferred from the light to the dark , and decrease exponentially ( t ( 1/2 ) = 75 min ) when cells are transferred from the dark to light .
C0026237
mitochondrial
C0007634
cells