intracerebroventricular ( i.c.v . ) injections of dihydropyridine derivatives calcium channel agonist ( bay k8644 ) and antagonist ( nifedipine , nicardipine , pn 200-110 ) induced opposite long-lasting changes in blood pressure ( bp ) in pentobarbital anesthetized spontaneously hypertensive rats ( smr ) .
C0012315
dihydropyridine
C0028005
nicardipine