these results are consistent with the view that ketogenesis which involves all three enzymes , acetoacetyl-coa thiolase , 3-hydroxy-3-methylglutaryl-coa synthase and 3-hydroxy-3-methylglutaryl-coa lyase , occurs exclusively in the mitochondrion , whereas cholesterogenesis , a pathway which involves only the 3-hydroxy-3-methylglutaryl-coa synthesizing enzymes , is restricted to the cytoplasm .
C0026237
mitochondrion
C0010834
cytoplasm