because thrombin aggregates afibrinogenemic platelets and platelets from patients with the gray platelet syndrome and because antibodies to fibrinogen inhibit thrombin-induced aggregation only at low concentrations of thrombin , the role of fibrinogen in the formation of thrombin-induced aggregates was investigated further with human platelets washed and resuspended in tyrode-albumin solution containing apyrase , either with or without added ca2+ ( 2 mmol/l ) .
C0001733
afibrinogenemic
C0016006
fibrinogen