we found that bone marrow fibroblasts from healthy elderly ( ages 65-75 years ) volunteers were less sensitive to the inductive effects of recombinant il-1 beta than were marrow fibroblasts from younger volunteers , and we proposed that an age-related decline in sensitivity of marrow stroma to il-1 may impair the ability of the elderly to increase production of hematopoietic growth factors under conditions of physiologic stress .
C0021753
il-1 beta
C0021755
il-1