the results of 12 double-blind , randomized , placebo- and cimetidine-controlled trials involving 4000 patients have been reviewed here and show that misoprostol , given in a dosage of 800 micrograms daily in two or four divided doses , is able to produce rates of complete ulcer healing and pain relief in both gastric and duodenal ulcer which are significantly superior to placebo therapy and comparable to those achieved with high or conventional doses of cimetidine .
C0008783
cimetidine
C0013295
duodenal ulcer