carcinoma of the colon was induced in rats by injection of a carcinogen 1,2-dimethylhydrazine ( dmh ) , and thymidylate synthetase ( ts ) and thymidine kinase ( tk ) activities , which catalyze the biosynthesis of dtmp by the de novo pathway and the salvage pathway of pyrimidine synthesis , respectively , were measured in normal control colon , dmh-treated normal colon , and dmh-induced colon carcinoma with or without administration of two doses of an anti-cancer drug uft ( a combination of tegafur and uracil ) .
C0009368
colon
C0699790
colon carcinoma