by transferring the heparin-protamine model to an animal ( rabbit ) system that picks up ongoing intravascular complement activation by documenting acute granulocytopenia due to margination , evidence that intravascular polyanion-polycation complexing leads to instantaneous activation of the c system in vivo that goes beyond c1 , c4 , and c2 , and results in generation of biologically highly reactive products , such as c5a , is provided .
C0009528
complement
C1367710
c5a