in patients with the extensive metabolizer phenotype , quinidine increased mean steady-state plasma propafenone concentrations more than two fold , from 408 +/- 351 ( mean +/- s.d . ) to 1096 +/- 644 ng ml-1 ( p less than 0.001 ) , decreased 5-hydroxypropafenone concentrations from 242 +/- 196 to 125 +/- 97 ng ml-1 ( p less than 0.02 ) and reduced propafenone oral clearance by 58 +/- 23 % .
C0034414
quinidine
C0033429
propafenone