these granules ( known as membrane coating granules [ mcg ] , or lamellar granules ) fuse with the apical cell surface of uppermost granular cells and discharge their contents into the intercellular space , where they are believed to play a role in establishing the permeability barrier of the epidermis and possibly in regulating the orderly desquamation of terminally differentiated keratinocytes .
C0007634
cells
C1159909
differentiated keratinocytes