a 2-fold increase of epidermal cyclic amp observed within 1-2 h of tpa application can be inhibited by indomethacin treatment and correlates with delayed accumulation of pge2 in tpa-treated epidermis , whilst immediate pge accumulation ( 5-10 min after tpa application ) which has been shown to be critical for development of tpa-induced epidermal hyperplasia is not accompanied by any change of the intraepidermal cyclic amp level .
C0012472
pge2
C0033559
pge