fifteen minutes after guanethidine , significant changes in the response of the heart rate to noradrenaline 0.5 mug/kg were obtained with guanethidine 1.25 , 5 , and 20 mg/kg , whereas fully developed hypersensitivity after 20 and 40 mg/kg did not occur until 6-24 hours later .
C0028351
noradrenaline
C0020517
hypersensitivity