a dose of 100 ng/ml of synthetic igf-i was without effect on basal gh release , but significantly decreased 10 ( -9 ) m grf-induced stimulation of gh secretion . these data indicate that in prepubertal male lambs : the stimulatory effect of grf is predominant over the inhibitory effect of srif , somatostatin inhibits trh stimulation of gh secretion in vitro , and igf-i may control gh secretion by modulating grf effects at the pituitary level .
C0040162
trh
C0032002
pituitary