dynamic systems , modelling the elementary act of nucleophilic attack on the carbonyl carbon atom of amide ( n-methyl-acetamide ) and ester ( methylacetate ) substrates by some compounds , simulating the nucleophilic group of various types proteases active site were calculated and analysed by the cndo/2 method , namely : 1 ) methoxyanion and the methanol ( serine proteases ) , 2 ) water molecule in the presence of formate anion ( carboxylic proteases ) and 3 ) mercaptide anion ( ch3s- ) ( thiolic proteases ) .
C0013879
elementary
C0007009
carbon