the vulnerability of neuroepithelial cells in the central nervous system ( cns ) to neoplastic transformation results from the interaction of several factors : the existence of a reserve population of stem cells , the capability of differentiated cells to reenter the kinetic cycle , the number of replicating cells at risk at a particular time , the length of time during which a particular cell population remains in the cycle , the state of differentiation and the further differentiation potential of that population , and the steps of differentiation that are achieved in successive cell generations .
C0007589
differentiation
C0007634
cell