a multicenter double-blind study was conducted in 416 patients ( 306 male , 110 female ) with active endoscopically proven duodenal ulcers who were randomly allocated to receive the prostaglandin e1 methyl ester analog ( misoprostol/cytotec ) , either in a dose of 400 micrograms twice daily ( 206 patients ) or 200 micrograms four times daily ( 210 patients ) .
C0085174
misoprostol
C0591321
cytotec