in adult nedh rats , administration of streptozotocin or implantation of transplantable insulinoma fragments produced reciprocal changes in insulin and glucose concentrations either resulting in the onset of insulin deficiency ( 5.9 fold decrease ) and hyperglycaemia ( 3.2 fold increase ) by 2 days , or hyperinsulinaemia ( 2.1 fold increase ) and hypoglycaemia ( 1.4 fold decrease ) by 6 and 8 days , respectively .
C0021641
insulin
C0020456
hyperglycaemia