both activated murine macrophages and different metastatic tumor cells ( b16-bl6 melanoma ; esb t-lymphoma ) attach , invade , and penetrate confluent vascular endothelial cell monlayer in vitro , by degrading heparan sulfate proteoglycans in the subendothelial extracellular matrix .
C0062503
heparan sulfate
C0015350
extracellular matrix