plasmas having no detectable factor viii-related antigen but moderate factor viii coagulant were obtained from two unrelated dogs homozygous for von willebrand 's disease and with the severe clinical expression of the disease . when these plasmas were gel-filtered in a buffer at physiologic ionic strength , the factor viii coagulant eluted in the bed volume as a single well-defined peak .
C0042974
von
C0015506
factor viii