by comparing the predictions of the model with what is known about the physiology and molecular biology of escherichia coli under different growth conditions , we are able to delineate the characteristics that such a control system would need to possess in order to be capable of regulating chromosome replication : the control operon has to lie fairly near the origin of replication and contain a moderate to strong promoter and an operator that competes for its repressor with other equally specific binding sites along the chromosome in an interaction that is somewhat weaker than usual ;
C0242961
origin of replication
C0008633
chromosome