studies on spontaneously hypertensive rats ( shr ) , which represent a model of genetically determined arterial hypertension , revealed that cardiac hypertrophy can be controlled by blood pressure normalization by use of various antihypertensive drugs such as hydralazine , captopril , metoprolol , guanethidine , and alpha-methyldopa .
C0020538
arterial hypertension
C0018318
guanethidine