the adequacy of anticoagulation during 2 hours of cardiopulmonary bypass at 30 degrees c in 9 rhesus monkeys was determined by measuring the whole-blood activated clotting time ( act ) and by noting the appearance of thrombin-altered fibrin ( fibrin monomer ) and the relative consumption of clotting factors .
C0040018
thrombin
C0005789
clotting factors