destruction in vivo , of the bis-quaternary structure essential for neuromuscular blocking activity , by the combination of hofmann elimination and a parallel ester hydrolysis leads to innocuous breakdown products that are without neuromuscular or cardiovascular effects and to a time-course of action which is unaffected by the level of plasma esterase activity , renal or hepatic function .
C0020291
hydrolysis
C0014894
esterase