the development of immunity in mice to bordetella pertussis induced by intracerebral , intravenous or intraperitoneal vaccination was analysed in terms of the viable bacteria in the brain after intracerebral challenge , the serum antibodies , and protection against the sublethal infection of the lung that follows intranasal inoculation.a vaccine introduced intracerebrally was five to ten times more effective than that given intraperitoneally or intravenously , as measured for each route by the amount of vaccine required to protect half the mice against an intracerebral challenge 14 days later ( imd 50 ) .
C0006017
bordetella pertussis
C0004611
bacteria