after noting pathological mechanisms which implicate each of these factors , and platelets , in reactions likely to contribute to the development of atherosclerosis , infarction , arterial spasm , and/or lung damage , the author concludes that the evidence in man , backed up by experimental data , provides very strong support for the view that elevations of wcc , haematocrit , plasma fibrinogen and reduction of the hdl/ldl ratio represent ( or are closely associated with ) intermediate causal mechanisms through which smoking induces arterial disease and probably lung disease , and that experimental evidence indicates that platelet changes and macrocytosis also contribute .
C0024109
lung
C0024115
lung disease