to test whether the mutation responsible for the loss of alpha-globin gene expression ( hemoglobin h disease ) in these patients is linked with the alpha-globin genes on chromosome 16 , we transferred chromosome 16 from preleukemic patients with acquired hemoglobin h disease to mouse erythroleukemia cells and measured the transcriptional activity of the human alpha-globin genes .
C0017262
gene expression
C0040649
transcriptional