3 the coincident diurnal variations in diazepam and n-desmethyldiazepam concentrations and the negative correlation between total diazepam concentration and diazepam free fraction ( r = 0.73 , p less than 0.001 ) suggest that the mechanism of the fluctuations is intravascular and tissue redistribution rather than effect on drug biotransformation .
C0011279
desmethyldiazepam
C0012010
diazepam