results from studies on the molecular control of growth and differentiation in normal myeloid hematopoietic cells , on changes in the normal developmental program , and on the suppression of malignancy in myeloid leukemia have shown that ( a ) malignancy can be suppressed by inducing differentiation either with or without genetic changes in the malignant cells , ( b ) this suppression of malignancy does not have to restore all the normal controls , and ( c ) genetic abnormalities that give rise to malignancy , which include changes in homeobox genes , can be bypassed and their effects nullified by inducing differentiation that stops cells from multiplying .
C0334227
malignant cells
C0006826
malignancy