thirty-eight patients whose primary extremity or limb girdle osteosarcomas had been completely excised ( 37 amputations , one limb sparing procedure ) were allocated at random to two treatment groups receiving respectively regular follow-up examinations plus a high-dose methotrexate ( hdmtx ) regimen or regular follow-up without primary adjuvant chemotherapy .
C0029463
osteosarcomas
C0025677
methotrexate