the effect of chlorpromazine ( cpz ) on the metabolism of dopamine and 5-hydroxytryptamine in dog brain was investigated by following the concentrations of the acid metabolites of these amines , homovanillic acid , 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolylacetic acid , in the ventricular cerebrospinal fluid ( c.s.f . ) of dogs over a period of 5 hr after intravenous administration of cpz ( 2.5 , 5 , 10 and 15 mg/kg ) , using the technique of serial sampling of lateral ventricular c.s.f .
C0006104
brain
C0086045
concentrations