it was found that : 1 ) the fundamental template restriction of chromatin ( as compared to deproteinized dna ) is retained in the isolated nucleosomes , 2 ) on the average one molecule of rna polymerase is bound to one molecule of dna purified from nucleosomes , 3 ) the number of rna polymerase binding sites on chromatin subunits is 6 to 20 times lower than that of the dna extracted from these subunits , 4 ) transcription can proceed through nucleosomes resulting in rna chains approximately 150 nucleotides long .
C0008546
chromatin
C0028623
nucleosomes