ultrastructural changes consisted of proliferation , pleomorphism and swelling of mitochondria , condensation of the mitochondrial matrix , cytoplasmic lucency and vacuolization , disaggregation of polyribosomal clusters , an initial increase followed by degranulation of rough endoplasmic reticulum , proliferation of smooth endoplasmic reticulum , an accumulation of dense bodies and a loss of intermediate glial filaments .
C0010834
cytoplasmic
C0230779
rough endoplasmic reticulum