in an effort to modify this inhibition and salvage jeopardized myocardium , treatment with excess levels of pyruvate and tromethamine ( tris ) , designed to buffer intracellular hydrogen ion accumulations and improve the oxidation-reduction ratio , nad+/nadh , was tested in 59 swine hearts in two separate preparations of global and regional ischemia .
C0027061
myocardium
C0018787
hearts