two days after the last dose , the mice were killed by decapitation and the concentrations of the brain catecholamines , norepinephrine ( ne ) , and dopamine ( da ) , and their metabolites , 3-methoxy-4-hydroxymandelic ( vma ) , homovanillic acid ( hva ) and dihydroxyphenyl acetic acid ( dopac ) and the indoleamine serotonin ( 5-ht ) and its metabolite , 5-hydroxyindoleacetic acid ( 5-hiaa ) were determined by high pressure liquid chromatography in six discrete brain regions .
C0086045
concentrations
C0006104
brain