we analyzed diploid cells in which one or both copies of chromosome iii carry a mutant centromere in place of the wild-type centromere and found that some alterations in the length , base composition and primary sequence characteristics of the central a+t-rich region ( cde ii ) of the centromere had a significant effect on the ability of the chromosome to segregate properly through meiosis .
C1517495
sequence characteristics
C0008633
chromosome