the discovery of selective postjunctional alpha 1-adrenergic-receptor inhibitors , such as prazosin and doxazosin , which preserve feedback control of transmitter norepinephrine release , was the crucially important step in the development of specific drugs to combat the hyperactivity of adrenergic vasoconstrictor nerves in hypertension .
C0032912
prazosin
C0114873
doxazosin