permeability studies were carried out with three lipophilic drugs , namely , phenytoin and primidone ( both widely used in the treatment of epilepsies and convulsive disorders ) , and dapsone ( a sulfone antimicrobial agent used in the treatment of leprosy and to a lesser extent in dermatitis herpetiformis ) through silica-filled poly ( dimethyl siloxane ) ( silastic ) membranes , and anisotropic membranes of poly ( ether-urethane ) /poly ( dimethyl siloxane ) block copolymer ( avcothane , cardiothane ) .
C0031507
phenytoin
C0014544
epilepsies