twenty-one male patients aged between 41 and 68 years and suffering from chronic stable angina pectoris and coronary artery disease confirmed by angiography took part in a randomized , double-blind study to examine the acute effect of 10 mg of bisoprolol , 20 mg of nifedipine , and a combination of the two drugs on hemodynamics at rest and during exercise [ heart rate ( hr ) , systolic blood pressure ( sbp ) , rate-pressure product ( rpp ) , cardiac index ( ci ) , total peripheral resistance ( tpr ) , and pulmonary capillary wedge pressure ( pcp ) ] , the behavior of the st segment ( st ) , and exercise tolerance until occurrence of an st-segment depression of 0.1 mv ( w-st01 ) and until onset of anginal pain ( w-ap1 ) .
C0053799
bisoprolol
C0002962
anginal pain