a hypothesis consistent with these data states that chromosome stickiness ( i ) results from changes in specific non-histone proteins ( topoisomerase ii and the peripheral proteins ) that are integral components of the chromosome and whose function is necessary for separation and segregation of chromatids , the changes being caused either by mutation in structural genes for the proteins ( heritable stickiness ) or by direct action of mutagens on the proteins ( induced stickiness ) ;
C0008633
chromosome
C0729606
components