during our systematic search for prostaglandins with improved tissue selectivity and metabolic stability , we synthesized a series of pge2 analogs in which the n-amyl carbinol side chain was systematically substituted by a phenyl ring , based on structural considerations incorporating the 17,18-cis-double bond of pge1 into an aromatic ring .
C0033554
prostaglandins
C0002335
pge1