to eliminate the undesirable edematogenic effect of the luteinizing hormone-releasing hormone ( lh-rh ) antagonists containing basic d amino acids at position 6 , exemplified by [ ac-d-phe ( pcl ) 1,2 , d-trp3 , d-arg6 , d-ala10 ] lh-rh [ phe ( pcl ) indicates 4-chlorophenylalanine ] , analogs with d-ureidoalkyl amino acids such as d-citrulline ( d-cit ) or d-homocitrulline ( d-hci ) at position 6 were synthesized and tested in several systems in vitro and in vivo .
C0301714
basic
C0002520
amino