the analysis of rearranged immunoglobulin and t cell receptor genes has been of value in defining the lineage ( t or b cell ) of neoplasms that were of controversial origin previously , determining the clonality of abnormal lymphocyte proliferations , diagnosing and monitoring the therapy of lymphoid malignancies , determining the state of maturation and the causes for failure of maturation of cells of the b cell series , and providing major insights into the cause of malignant transformation of b and t lymphoid cells .
C1511002
maturation
C0007634
cells