chronic exposure of gh3 cells to tpa , which strongly down-regulates protein kinase c activity , completely inhibited acute tpa stimulation of transient expression of a transfected prl promoter construct ( ( -187 ) prl-cat ) , but did not inhibit egf stimulation of either accumulation of endogenous prl mrna or of expression of ( -187 ) prl-cat .
C0007634
cells
C0086860
construct