analysis of the location of the mutations in the primary and tertiary structures of class a beta-lactamases suggests that interactions between the substituted residues and beta-lactam antibiotics non-hydrolysable by tem-1 and tem-2 allow tem-4 and tem-5 to hydrolyse efficiently novel broad-spectrum cephalosporins such as ctx and caz .
C3536856
cephalosporins
C0007559
caz