the principle involves a ) using the high affinity of certain cell-bound antibody isotypes for intercalating c1q from serum of various species , b ) selecting such antibodies as are syngeneic to the immunized animal species , thus avoiding the production of antibodies against the intercalating antibodies and c ) screening for the anti-c1q mab in microtiter plates coated with c1q-intercalating mab isotypes that are heterogeneic to the immunized animal species .
C0021017
antibody isotypes
C0003241
antibodies