this sedative effect was dose-dependent.4 the sedative effects induced by histidine after dopa-induced arousal in reserpine-treated rabbits and mice were prevented by prior injection of the histamine h ( 1 ) -receptor blockers , chlorpheniramine ( 2.5 mg/kg ) or diphenhydramine ( 5 mg/kg ) .5 imipramine ( 7 to 10 mg/kg , i.v . ) -induced arousal in reserpine-treated rabbits was also reversed by histidine infusion.6 the infusion of 5-hydroxytryptophan ( 100 mg/kg , i.v . ) with l-dopa , or of arginine ( 450 mg/kg , i.v . ) with or after l-dopa , or of histamine ( 100 mug/kg ) , i.v . )
C0013023
dopa
C0023570
l-dopa