the actions of 2,6-dimethyl-3,5-dicarbomethoxy-4- ( 2-isothiocyano ) phenyl-1,4- dihydropyridine ( o-ncs-dhp ) , a nifedipine analog bearing a reactive group , have been characterized in vitro by pharmacological and radioligand binding techniques in a number of smooth muscles and in vivo by blood pressure and radioligand binding . o-ncs-dhp exhibits persistent , but slowly reversible , antagonism in guinea pig ileal longitudinal smooth muscle , guinea pig bladder , taenia coli , rat portal vein , and rat tail artery to receptor responses ( muscarinic and alpha-adrenoceptor ) and k+ depolarization initiated responses .
C0012315
dihydropyridine
C0028066
nifedipine