by transfection of these hybrid cells with a plasmid carrying a modified human beta-globin gene and a foreign gene composed of the coding sequence of the bacterial neomycin-resistance gene linked to simian virus 40 transcription signals ( svneo ) , cells were obtained in which the two genes are integrated at the beta-globin locus on human chromosome 11 or at random sites .
C0079941
coding
C0007634
cells