to determine the role of proinsulin on endogenous insulin release , splanchnic output and arterial concentrations of c-peptide were measured in healthy subjects before and during infusion of human ( hpi ) and porcine ( ppi ) proinsulin at increasing rates for 70 min each ( hpi , 328 and 656 micrograms x m-2 x h-1 ; ppi , 54 , 134 , and 268 micrograms/m-2 x h-1 ) , while euglycemia was maintained by variable glucose infusion .
C0021641
insulin
C0033362
proinsulin