treatment of diploid human fibroblasts with stereoisomeric benzo [ alpha ] pyrene anti and syn diol epoxides has been shown to induce anchorage-independent clones of cells with a dose dependence and frequency [ ( 0.5-12 ) x 10 ( -4 ) ] not significantly different from mutations at the hypoxanthine-guanine phosphoribosyltransferase locus [ ( 1-8 ) x 10 ( -4 ) ] in these cells .
C1708726
locus
C0007634
cells