in the belief that homocysteine-induced convulsions might be related to alterations in brain gamma-aminobutyric acid metabolism , we have studied the action of this amino acid on the activity of glutamic decarboxylase ( gad , ec 4.1.1.15 ) and gamma-aminobutyrate aminotransferase ( ec 2.6.1.19 ) of mouse brain in vitro dl-homocysteine competitively inhibited gad with respect to both l-glutamate and pyridoxal 5'-phosphate .
C0036572
convulsions
C0034266
pyridoxal 5