a comparison was made between the results of an analysis of humoral immunological changes in 64 cases of inflammatory diseases of the connective tissue of children ( 32 cases of acj , 5 cases of systemic lupus erythematosus , 2 cases of polymyositis , and 25 cases of systemic vasculitis ) , and data reported in recent literature , the authors conclude as follows : -- changes of the immunological parameters that were tested support the hypothesis of a humoral immunopathogenic mechanism in systemic lupus erythematosus , in some of the manifestations of acj , and in systemic vasculitis ; -- of particular value for the immunological diagnosis of acj is the detection of fr in the patients ' serum ( and especially of fr from the igg and the iga class ) , as well as changes of immunological parameters of the articular fluid ( the presence of fr , of immune complexes , a reduction of the titer intra-articular complement , the presence of ragocytes ) ; -- demonstration of humoral immunological changes ( polyclonal hypergammaglobulinemia , the presence in the serum of circulating immune complexes , and of cryoglobulins , the low titer of serum complement in active stages , the presence of antinuclear antibodies , and especially of antinative dna , the presence of le cells in peripheral blood , and of a varied range of autoantibodies ) is mandatory for the diagnosis of systemic lupus erythematosus ; -- in the present stage of our knowledge humoral immunologic changes are not an absolutely certified criterion for the diagnosis of polymyositis , and of some cases of systemic vasculitis ( henoch-schoenlein purpura ) .
C0009498
complement
C0229671
serum