rather , genetic predisposition ( particularly , inherited immunoregulatory abnormalities ) and environmental links in the causal chain of disease ( antigenic exposures , trauma , or other insults ) have been postulated to interact with each other and with additional host susceptibility factors ( acquired faulty immune system regulation , age , nutritional status , endocrine status , etc . ) .
C0314657
genetic predisposition
C0012655
susceptibility