reporting a case of cutaneous tumor of the back of recent occurrence and rapid increase in a 79-years-old woman , according to crosti 's `` '' reticulosis '' '' , the authors discuss the following points : -- the histiocytic nature of the tumor cells particularly based on immunohistochemical studies ( peroxidase activity , anti-htla serum ) and on electron microscopy with special reference to the multivesicular bodies found in their cytoplasm ; -- the tests for correct identification of the histiocyte ( including electron microscopy , tests for htla and hbla antigens , peroxidatic reaction , acid phosphatase activity , and in vivo or in vitro phagocytosis ) ; -- the out of date character of the concept of malignant `` '' reticulosis '' '' in the hematologica and dermatologic classifications , the recent advances in the knowledge of the nature of the so-called `` '' reticulum '' '' ( or `` '' reticular '' '' ) cell which seems to be a distinct entity derived from the mesenchymal cell ( as the fibroblast ) ; -- the clinical and evolutive characteristics of histiocytic tumors ( no hematologic involvement , slow evolution , high radiosensitivity ) , the difficulties in defining their malignancy and , above all , in finding comparable references in the literature with complete cellular study ; -- the nosologic place of this affection among the group of haematodermas and in the pathology of the mononuclear phagocyte system .
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