reported findings of elevated total calcium ( ca ) contents in erythrocytes ( rbcs ) from patients with beta-thalassemia intermedia ( beta-ti ) prompted the question of whether the state and transport of ca in these rbcs are similar to those in sickle cell anemia ( ss ) rbcs where the increased ca is compartmentalized in endocytic inside-out vesicles and extracted by exposure of the cells to the ca ionophore a23187 and a ca chelator ( ethylene glycol tetraacetic acid ) and the levels of cytoplasmic free ionized ca [ ( ca2+ ] i ) are normal .
C0007634
cells
C0010834
cytoplasmic