by means of the direct sister chromatid exchange ( sce ) assay in v79-e cells in the presence of rat blood , serum or plasma , respectively , as well as by a 'host-mediated ' sce assay ( in which the agent was given i.v . to rats , and blood taken from the animal was checked for the recovery of genotoxic activity in cell cultures ) , we tried to elucidate the unexpected lack of carcinogenic activity of i.v .
C0229671
serum
C0032105
plasma