( two h after the administration of single p.o . doses of 1 to 10 mg/kg of procarbazine to rats , o6-methylguanine formation in leukocyte dna was just under half that in liver dna and showed a linear relationship with dose with a slope of 0.017 fmol/microgram of dna per mg/kg of body weight or 5.67 x 10 ( -4 ) fmol of o6-methylguanine/microgram of dna per mg/m2 .
C0598312
formation
C0012854
dna