although the hiv-1 rt associated rnase h activity shares many of the general mechanistic features of other retroviral enzymes [ gerard , g. f. ( 1981 ) biochemistry 20 , 256-265 ] , the appearance of unique intermediates and end products in the course of hydrolysis of 5'-mismatched and fully base-paired hybrids indicated a significant difference in the sequence dependence of the kinetics of rnase h cleavage by hiv-1 rt and m-mulv rt .
C0020291
hydrolysis
C0014241
rnase