this increase of bronchial responsiveness to histamine after repeated histamine challenges was reduced by pretreatment with clemastine ( histamine h1-receptor antagonist , 0.12 mg/kg i.p. , n = 7 , p less than 0.05 ) and more effectively by combined clemastine/cimetidine pretreatment ( combined h1-h2-receptor antagonists , 0.12 resp . 10 mg/kg , n = 7 , p less than 0.001 ) ;
C2919009
histamine h1-receptor antagonist
C2757048
h1