in conscious spontaneously hypertensive ( sh ) rats , continuously infused with clonidine ( 500 micrograms/kg/day s.c. ) for 12 days , yohimbine ( 3 or 10 mg/kg i.p . ) dose dependently precipitated an overshoot of heart rate and other withdrawal symptoms , such as blood pressure upswings , diarrhea , ptosis , body shivering , jumping , and wet-dog shakes .
C0009014
clonidine
C0011991
diarrhea