also , mn2+ with gtp , but in the absence of beta-agonist , is very potent in reversing the gpp ( nh ) p permanently active state to the basal state . beta-receptor ( r ) to guanyl nucleotide regulatory protein ( n ) coupling still occurs at inhibitory mn2+ concentrations , since the intrinsic kinetic parameters which characterize the r to n coupling interrelationship are unaffected by mn2+ at a wide concentration range .
C0018353
gtp
C0018366
gpp ( nh ) p