in order to determine whether vasodilator prostaglandins ( pg ) contribute to the acute vascular and endocrine responses to intravenously administered dihydralazine , we examined its effects on systolic and diastolic blood pressure ( bp ) , heart rate ( hr ) , plasma renin activity ( pra ) and the plasma catecholamines ( ca ) noradrenaline ( na ) , adrenaline ( a ) and dopamine ( da ) as well as on sodium , potassium and creatinine clearance ( cna , ck and ccr respectively ) , urinary flow rate , urinary catecholamines ( na , a , da ) and ipge2 and i6-keto-pgf1 alpha excretion rate in six patients ( three females , three males ) with essential hypertension before and after pg synthesis inhibition by the nonsteroidal , anti-inflammatory agent diclofenac .
C0007412
catecholamines
C0013030
da