within the period from 3.5 to 19 months following injection of the metabolites in the urinary bladder of animals , there were observed focal proliferates of the epithelium not infrequently with its atypism , and also lymphoid infiltration of submucous and muscle layers , reticulosarcomas , papillomas , precancerous conditions and cancer .
C0005682
urinary bladder
C0225358
muscle layers