in the last year , two large randomized controlled trials of metoprolol ( miami , almost 6,000 patients ) and atenolol ( isis 1 , over 16,000 patients ) given intravenously within 12 hours of the onset of acute myocardial infarction reduced mortality by about 15 % in low-risk subjects .
C0004147
atenolol
C0027051
myocardial infarction