the hypertrophied smc showed important morphological and ultrastructural modifications -- irregular shape , increase in the number of organelles ( particularly of golgi apparatus , free ribosomes , rough endoplasmic reticulum and microtubules ) , large indented nuclei rich in euchromatin -- indicating profound changes in their metabolic and contractile activity which could result in an alteration of their mechanical properties .
C1179933
free
C0230779
rough endoplasmic reticulum