one analog , sc 25152 , was found to have considerably reduced affinity for the prostate 5 alpha-dihydrotestosterone receptor [ ka = 24 +/- 1 % and 19 +/- 6 % ( mean +/- se ) in the human and rat , respectively , of the ka for spironolactone ] while maintaining similar affinity for the mineralocorticoid receptors of human and rat kidney [ ka = 113 +/- 37 % and 86 +/- 7 % ( mean +/- se ) , respectively , of the ka for spironolactone ] .
C1367578
dihydrotestosterone receptor
C0086418
human