our results demonstrated that : leukemic sera induced a 170 % increase in total fibroblast colony numbers and a 325 % increase in colonies containing more than 80 cells , stimulation of fibroblast growth was leukemia related since sera from rats with transplanted leukemia enhanced marrow fibroblast proliferation , leukemic cell cm did not contain a growth factor for marrow fibroblasts , sera from leukemic rats and 2-mercaptoethanol were additive in enhancing marrow fibroblast proliferation and probably act by different mechanisms , and leukemic rat sera was less effective as a colony-stimulating factor than normal rat sera , a condition mimicked when leukemic and normal spleen cm were compared .
C0007634
cells
C0016030
fibroblast