it is suggested that each phosphate group of ppi makes equal contribution to the interaction with dna polymerases and that the distance between the phosphate groups is important for this interaction . beta-phosphate of ntp or dntp is suggested to make negligible contribution to the efficiency of the formation of enzyme complexes with dntp . beta-phosphate is likely to be an essential point of ppi interaction with the active center of proteins during the cleavage of the alpha-beta-phosphodiester bond of dntp in the reaction of dna polymerization .
C0012892
dna polymerases
C0314672
polymerization