the progressive spread in asia and south america of falciparum malaria resistant to 4-aminoquinolines , and the focal occurrence in all malarious regions of infections resistant to dihydrofolate dehydrogenase inhibitors such as pyrimethamine and proguanil , make it everywhere necessary to be alert to the failure of accepted curative , prophylactic , or sporontocidal chemotherapeutic agents .
C1373048
dihydrofolate dehydrogenase inhibitors
C0008241
proguanil