blood pressure ( bp ) , heart rate ( hr ) , plasma catecholamines ( pca ) , beta-adrenergic responsiveness to isoproterenol ( dose that increased hr by 25 beats/min = cd25 ) , lv mass as well as systolic function ( 2d-guided m-mode echo ) , at rest and during stress ( handgrip test [ hg ] , 30 % max , for 3 min ) , were measured on placebo , after 1 and 6 months of monotherapy with verapamil ( ver , 240 mg/day , 9 patients ) or nifedipine ( nif , 40 mg/day , 10 patients ) .
C0022245
isoproterenol
C0039231
increased hr