maximal doses of lofexidine and clonidine in combination with hydrochlorothiazide had equivalent antihypertensive effects , but when the effects of lofexidine and clonidine were compared at each dose level , larger doses of lofexidine patients in either the supine or erect position during the titration phase but heart rate fell in the clonidine patients ( p less than 0.05 ) over the same period .
C0065152
patients
C0009014
clonidine