the tyr-to-asp replacement at residue b16 in the insulin analogue had been expected to diminish the rate of cleavage of the molecule by the enzyme insulin proteinase , since the bond tyrb16-leub17 , invariant in all mammalian species , had been proposed by other authors as one of the early , major sites of proteolytic attack .
C0021669
insulin proteinase
C0597304
proteolytic