two early steps of angiotensin ii-induced biological response have been examined in cultured rat aortic , smooth muscle cells : ( a ) in addition to rapidly raising inositol 1,4,5-trisphosphate production , angiotensin ii also induced the appearance of the isomer , inositol 1,3,4-trisphosphate , with similar kinetics : ( b ) inositol 1,4,5-trisphosphate released calcium from an intracellular pool in electropermeabilized smooth muscle cells , in a concentration-dependent manner ( ec50 = 0.25 microm ) .
C1267092
smooth muscle
C1135918
smooth muscle cells