multistage models of carcinogenesis proposed to account for the observed patterns of tumor development in the skin , liver , lung , bladder and other organs involve initiation of neoplastic change in a few cells by a threshold dose of carcinogen followed by conversion of these latent tumor cells into an autonomous cancer by further doses of the same and/or other carcinogens , and/or noncarcinogenic promoting agents .
C0027651
tumor
C0006826
cancer