pharmacokinetics of methotrexate ( mtx ) was studied in 34 patients ( age 1-25 years , median 12 years ) predominantly with primary brain tumors and osteosarcoma , who received a total of 64 high-dose infusions ( 12 g/m2/4 h , maximum dose 20 g ) , followed by leucovorin rescue ( coss 82 ) .
C0025677
methotrexate
C0029463
osteosarcoma