we conclude that 1 ) pco women have significant insulin resistance that is independent of obesity , changes in body composition , and impairment of glucose tolerance , 2 ) pco and obesity have a synergistic deleterious effect on glucose tolerance , 3 ) hyperinsulinemia in pco is not the result of decreased insulin clearance , and 4 ) pco is associated with a unique disorder of insulin action .
C0021655
insulin resistance
C0020459
hyperinsulinemia