using alkaline elution assays , we measured a 30 % increase in dna strand breaks in cells treated with ara-c followed by dipyridamole when compared to cells treated with ara-c alone , while dipyridamole alone did not produce dna lesions . ara-c resistance in tumor cells is associated with either the natural substrates competing with ara-c for phosphorylation and incorporation into macromolecules or increased catabolism of the parent drug .
C0000702
a
C0012854
dna