although the exact cause of post transplant atn remains unknown , the following factors are thought to be associated with a higher incidence of atn : 1 ) donor hypotension , 2 ) prolonged `` '' warm ischemia time '' '' , 3 ) increased vascular resistance with poor perfusate flow , 4 ) presence of `` '' ligandin '' '' or excess lactate in the renal perfusate , 5 ) reduced allograft blood flow , 6 ) cold lymphocytotoxins in the patient 's serum and 7 ) administration of nephrotoxic drugs particularly to the hypovolemic graft recipients .
C0022672
atn
C0022646
the r