the synthetic oestrogen hexoestrol , administered at 60 mg/kg/day for 4 days to female rats in 3 studies , caused the following mean changes in the relative weights of some of the principal organs : liver ( +37 % ) , spleen ( -11 % ) , adrenals ( +43 % ) , kidneys ( +3 % ) , pituitary ( +23 % ) , uterus ( +49 % ) , and ovaries ( +13 % ) .
C0001625
adrenals
C0022646
kidneys