we have shown elsewhere that our neonatally tolerized animals have a centrally induced delection-type tolerance in the absence of obvious suppression.2 we now suggest that in the neonatally tolerized mouse , chronic , central delection of anti-h-2k clones during early t cell ontogeny eliminates the major source of cells able to give rise , via somatic mutation and expansion , to anti-h-2kk + vaccinia specific cytotoxic t lymphocyte precursors ( ctl-p ) in the adult .
C1515126
t cell ontogeny
C0007634
the