we have previously shown that when rats are continually exposed to 1,2-dimethylhydrazine ( sdmh ) in a manner that induces malignant hemangioendotheliomas of the liver there was both accumulation of promutagenic dna damage , as measured by o6-methylguanine ( o6mg ) and a selective increase in cell replication in the target cell population , the nonparenchymal cells ( npc ) .
C0007590
cell replication
C0007634
cells