it is postulated that since hypothalamic norepinephrine ( ne ) is known to inhibit corticotropin-releasing hormone ( crh ) , an increase in brain ne as measured by its metabolite 3-methoxy-4-hydroxy-phenylglycol ( mhpg ) could reflect the depression of the hypothalamic-pituitary-adrenal ( hpa ) axis as measured by urinary cortisol levels .
C0020663
hypothalamic
C0010132
corticotropin-releasing