we previously reported that insulin-like growth factor-ii ( igf-ii ) stimulates both calcium influx and dna synthesis by acting on the cell surface igf-ii receptor ( igf-iir ) in a manner sensitive to pertussis toxin , and recently demonstrated that igf-ii binding to the igf-iir gives rise to functional changes of purified gi-2 , a gtp-binding protein ( g protein ) in phospholipid vesicles as well as in broken cell membranes .
C0034800
cell surface
C0007603
cell membranes