bolus administration of naloxone ( 5 mg/kg ) significantly increased both plasma epinephrine ( p less than 0.01 ) and norepinephrine ( p less than 0.05 ) over shock levels along with a transient but significant increase in cardiac output ( p less than 0.05 ) and mean arterial pressure ( p less than 0.05 ) , and a significant decrease in heart rate ( p less than 0.05 ) .
C0028351
norepinephrine
C0036974
shock