in rat-1 fibroblasts , 125i-labeled egf is internalized following binding to the surface receptor , and is transported through intracellular organelles where it undergoes a series of modifications which result in acidification of the egf ( matrisian et al. , 1984 , j. biol . chem . 259 , 3047 ) .
C0597358
binding
C0242275
egf