ninety-six patients with advanced chronic lymphocytic leukemia ( cll ) ( stage c ; anemia and/or thrombocytopenia of nonimmune origin ) were randomized to receive either chlorambucil ( clr ) ( 0.4 mg/kg orally , day 6 ) plus prednisone ( pdn ) ( 60 mg/m2 orally , days 1-5 ) every 2 weeks or cyclophosphamide ( 600 mg/m2 intravenously , day 6 ) , vincristine ( 1 mg/m2 intravenously , day 6 ) and prednisone ( 60 mg/m2 orally , days 1-5 ) ( cop ) each month for 5 months .
C0023434
chronic lymphocytic leukemia
C0008163
chlorambucil