16 patients with transfusion-dependent , life-threatening bone marrow failure ( 14 with severe aplastic anaemia , 1 with systemic lupus erythematosus and 1 with pure red cell aplasia ) were treated with cyclosporin-a ( cy-a ) after either lack of response to conventional immunosuppression with antithymocyte-globulin/high-dose methylprednisolone for 95 to 1190 days ( median 186.5 ) ( group i , 8 patients ) or as a primary treatment due to ineligibility for conventional immunosuppression ( group ii , 8 pat . ) .
C0024141
systemic lupus erythematosus
C0010592
cyclosporin-a