of 1116 patients receiving primary treatment for breast carcinoma at the royal marsden hospital since 1976 , 651 had an abnormal bone scintigram either at primary diagnosis ( 378 ) or on subsequent follow-up ( 273 ) and 167 developed radiographically detectable bone metastases ( 21 at the time of primary diagnosis ) .
C0262950
bone
C0153690
bone metastases