diphenylhydantoin ( phenytoin ) added to cultures of osteoblast-like cells at a concentration of 10 microm , at the high end of the therapeutic range in plasma of unbound phenytoin ( 4-8 microm ) , caused reductions in na+ , k+-atpase and alkaline phosphatase activities and increases in ca2+-atpase and hco3 -- atpase activities in homogenates of whole cells and in subcellular fractions of cultured osteoblast-like cells .
C0001473
atpase
C0001476
ca2