the criteria of effectiveness were clinical , electrocardiographic ( reversal of the ventricular fibrillation ) , biochemical ( simultaneous and opposite changes in extra- and intracellular potassium levels , suggesting that atpase inhibition by digitalis is a reversible process ) and toxicological : there was an increase in digitoxin serum levels suggesting displacement of the drug from tissue sites to plasma and other extracellular compartments where the fab fragments are distributed , and fab-bound digitoxin appeared fairly rapidly in the urine , which suggested shunting of the normal hepatic metabolic pathway .
C0042510
ventricular fibrillation
C0012258
digitoxin