autopysi disclosed moderate to severe loss of motor neurones in the hypoglossal nuclei and anterior spinal horns , absence of pyramidal tract demyelination , depigmentation of the substantia nigra and numerous neurofibrillary tangles in the hypothalamic region , parahippocampal gyrus , reticular substance of the mesencephalon and pons and in some brain stem nuclei .
C0038590
substantia nigra
C0025462
mesencephalon