the stimulating effect of c20:4 on renin release is assumed to be caused directly by formation of prostaglandin endoperoxides in the kidney cortex and not by prostaglandins since in vitro a natural prostaglandin endoperoxide ( pgg2 ) and two stable synthetic prostaglandin endoperoxide analogues ( epa i and epa ii ) do increase the release of renin , but pge2 has no effect and pgf2alpha inhibits renin release .
C0033554
prostaglandins
C0012472
pge2