the characteristics of bronchial hyperresponsiveness ( bhr ) were studied in 18 smokers with mild chronic air-flow limitation ( cal ) by measuring responsiveness to inhaled histamine , methacholine ( high dose ) , methoxamine ( an alpha-adrenergic agonist ) , and histamine after ipratropium bromide .
C0085129
bronchial hyperresponsiveness
C0600370
methacholine