the a431 antigen recognized by egfr1 has an apparent molecular weight of approximately 175,000 , is a cell-surface molecule which can be specifically cross-linked to egf , exhibits an egf-stimulated protein kinase activity , binds to egfr1 in a number of human cell lines to a degree which parallels egf binding , and shows egf-dependent internalization in a431 cells and human fibroblasts .
C0699040
cell-surface
C0007634
cells