prior to the onset of cirrhosis the liver showed a characteristic lesion consisting of hepatomegaly , periportal fatty change , portal cellularity due to proliferation of ovoid and cuboidal duct cells , gross enlargement of the hepatocyte cytoplasm nuclei and nucleoli in spite of brisk mitotic activity , and focal centrilobular necrosis .
C0019209
hepatomegaly
C0020564
enlargement