previous studies of the interactions of one such ultimate carcinogen , benzo [ a ] pyrene diol epoxide ( bpde-i ) with nuclei , chromatin and purified dna , demonstrated that although some bpde-i-dna interactions were altered in chromatin , covalent binding to chromatin dna at saturating chromatin concentrations was quantitatively the same as binding to purified dna .
C0007610
nuclei
C0008546
chromatin