kinetics studies performed in vitro on brain tryptophan 5-hydroxylase showed that aflatoxin treatment in vivo increased the km of the hydroxylase when l-tryptophan and synthetic 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin were used as the substrate and cofactor , respectively .
C0041252
tryptophan
C0020364
hydroxylase