based on ( 1 ) the large numbers of mast cells present in neurofibromas , ( 2 ) the possibility that these mast cells contribute directly to neurofibroma growth , and ( 3 ) the ability of ketotifen therapy to stabilize ( ie , block ) mast-cell secretion , treatment with ketotifen was started in a patient with severe neurofibromatosis ( nf ) in august 1983 .
C0027830
growth
C0027831
neurofibromatosis