when the quinolones were administered intravenously to mice concomitantly with oral biphenylacetic acid , a major metabolite of the nonsteroidal antiinflammatory drug fenbufen , enoxacin , norfloxacin , ciprofloxacin , and pipemidic acid , which have an unsubstituted piperazine moiety at the 7 position of their parent nuclei , provoked clonic convulsions and subsequent death at doses of 6.25 mg/kg or more in a dose-dependent manner .
C0034428
quinolones
C0008809
ciprofloxacin