to test the hypothesis that estradiol-17 beta ( e2 ) directly affects the number of gnrh receptors in the pituitary , independent of gnrh secretion , ovariectomized ewes with hypothalamic-pituitary disconnections ( hpd ) were given 25 micrograms ( i.m . ) of e2 ( hpd + e2 , n = 5 ) or oil ( hpd + oil , n = 5 ) .
C0023610
gnrh
C0020663
hpd