on larger dosages a phenothiazine-like blockade of the monoaminergic receptor is added to the blockade of monoamine reuptake thought to be related to the antidepressant action of the drugs.this study thus suggests two possible reasons for a therapeutic failure with nortriptyline : a too low or a too high plasma level .
C0003289
antidepressant
C0028420
nortriptyline