to test the possibility that cytokines participate in the autoimmune destruction of the pancreatic beta-cells leading to insulin-dependent diabetes mellitus , isolated human or rat islets of langerhans were incubated for 7 days with cytokine-rich , cell-free supernatants of blood mononuclear cells from healthy human donors stimulated with or without purified protein derivative of tuberculin or phytohaemagglutinin .
C0030281
pancreatic beta-cells
C0022131
islets of langerhans