1 the effect of exposing isolated preparations of rat aortic strip , rat atria and mouse vas deferens to perfusions of krebs solution containing various concentrations of noradrenaline on their sensitivity to the drug has been determined.2 the responses evoked by stimulation of postsynaptic adrenoceptors in all the tissues and presynaptic alpha-adrenoceptors in the mouse vas deferens were diminished by the perfusion of noradrenaline through the organ bath for 30 min.3 the concentration of noradrenaline required to produce desensitization was higher in the mouse vas deferens than in the other tissues and more was required to desensitize the chronotropic responses than the inotropic responses in rat isolated atria.4 the inclusion of cocaine ( 10 ( -5 ) m ) in the bathing solution to block uptake ( 1 ) increased the sensitivity of most tissues to noradrenaline .
C0034783
adrenoceptors
C0034784
alpha-adrenoceptors