experiments have been conducted to investigate a possible mechanism which might explain why aurothiomalate ( autm ) , a gold complex used in the treatment of rheumatoid arthritis , is active in vivo but not in vitro , by testing the hypothesis that autm is converted to aurocyanide by activated polymorphonuclear leukocytes ( pmn ) which generate cyanide from thiocyanate , an anion which is present in plasma at concentrations ranging from 20 to 200 microm .
C0018026
gold
C0003873
rheumatoid arthritis