prolonged exposure of a-10 cells to arginine vasopressin ( avp ) resulted in the following responses : ( a ) loss of vasopressin receptors from the cell surface ( 30-40 % ) , ( b ) increased basal levels of inositol and inositol monophosphate , ( c ) decreased inositol di- and trisphosphate production and decreased intracellular calcium release in response to a second challenge with avp , ( d ) attenuation of avp-mediated inhibition of isoproterenol-stimulated camp and anf-stimulated cgmp accumulation and ( e ) attenuation of thrombin and atp-mediated increase in inositol di- and trisphosphate accumulation and intracellular calcium release .
C0007634
cells
C0699040
cell surface