the following alterations in gallbladder function developed concurrently with biliary cholesterol crystallization , but before gallstone formation : ( a ) decreased gallbladder emptying , ( b ) increased intragallbladder pressure in response to cholecystokinin-octapeptide , ( c ) increased cystic duct closing pressure , and ( d ) increased resistance to outflow through the cystic duct .
C0008350
gallstone
C0037167
cholecystokinin-octapeptide