the results of the present study on the kinetics of u-pa activity in cultured macrophages , its subcellular localization and the effect of an organophosphorus ester are consistent with the concept that the development of pericellular proteolysis proceeds through a series of stages , namely , ( a ) synthesis of pro-u-pa , ( b ) binding to membrane receptors , ( c ) activation to a double-chain u-pa , and ( d ) conversion of plasminogen into plasmin .
C0597304
proteolysis
C0032140
plasminogen