when the cells were incubated in the presence of 50 microm chloroquine , the radioactivity found as cholesteryl ester in the lysosome-rich fraction increased to 45.5 % while that in microsome-rich fraction decreased to 21.4 % , indicating that ldl-cholesteryl ester accumulated in lysosomes as a consequence of inhibition of lysosomal function .
C0007634
cells
C0024369
lysosomes