we report here that the delayed onset of mitogen- or alloantigen-induced interleukin-2 synthesis and t-cell proliferation as well as the development of cytotoxic t-lymphocyte activity of enriched t-cell populations is strictly correlated with the time point of t-cell subset diversification in nu/nu mice and depends in particular on the presence of the lyt-1 ( tl- : lyt-2- ) t-cell set which is lacking in splenic t-cell populations of germ-free young nu/nu mice .
C1155046
t-cell proliferation
C0007634
the