in 20 dogs , epicardial bradykinin applied before production of transmural myocardial infarction produced a maximal pressor response of 13 +/- 3 mm hg 40 sec after application ( p less than .01 vs preapplication values ) , while topical nicotine produced a maximal depressor response of 14 +/- 2 mm hg ( p less than .01 vs preapplication values ) 20 sec after application at all sites tested .
C0027051
myocardial
C0028040
nicotine