in an attempt to shrink primary osteogenic sarcoma and allow complete surgical removal of the primary tumor , without amputating the involved limb , intensive preoperative chemotherapy with high dose methotrexate ( hdmtx ) with citrovorum factor rescue ( cfr ) and adriamycin ( adr ) was initiated in 20 patients with biopsy-proven primary osteogenic sarcoma of the distal femur ( 15 patients ) and proximal tibia ( five patients ) .
C0025677
methotrexate
C0029463
osteogenic sarcoma