single oral administration of amosulalol antagonized the phenylephrine-induced pressor and isoproterenol-induced positive chronotropic responses with dr10 values of 11.5 and 13.6 mg/kg in pithed rats , respectively , indicating that the compound inhibits both alpha 1- and beta 1-adrenoceptors to almost the same extent in agreement with previously reported results in vitro .
C0022245
isoproterenol
C1372804
positive