1 the characteristics of storage of amphetamine-releasable amine in rat heart and brain were studied in vitro with labelled and unlabelled metaraminol ( [ ( 3 ) h ] -ma and ma ) .2 in one series of experiments , heart and brain slices were incubated with [ ( 3 ) h ] -ma prior or subsequent to incubation with the same concentration of ma.3 when brain slices , thus treated , were subjected successively to field stimulation and to amphetamine , it was found that the ratio of [ ( 3 ) h ] -ma release by field stimulation to release by amphetamine was dependent upon the order in which brain tissue was exposed to [ ( 3 ) h ] -ma and ma.4 with heart slices , on the other hand , the field stimulation/amphetamine ratio of [ ( 3 ) h ] -ma release remained the same whether the tissue was exposed to [ ( 3 ) h ] -ma before or after ma.5 the ( + ) -isomer of amphetamine released three to four times more [ ( 3 ) h ] -ma from brain slices than did the ( - ) -isomer , while the isomers were equipotent with regard to [ ( 3 ) h ] -ma release from heart slices.6 amphetamine-induced [ ( 3 ) h ] -ma release from heart slices was unaffected by the presence of alpha-methyl-p-tyrosine , while release from brain slices was inhibited.7 on the basis of the foregoing results it appears that amine storage differs in brain and heart , with brain exhibiting more than one functional amine pool .
C0086045
concentration
C0006104
brain