the muscarinic-receptor-dependent [ ca2+ ] i rises were the result of two concomitant processes : ( 1 ) redistribution of ca2+ from cytoplasmic stores to the cytosol , possibly mediated by generation of inositol 1,4,5-trisphosphate as a consequence of the muscarinic-receptor-coupled hydrolysis of polyphosphoinositides , and ( 2 ) increased ca2+ influx through a pathway of the plasmalemma insensitive to verapamil and thus different from the voltage-dependent ca2+ channel .
C0010834
cytoplasmic
C1383501
cytosol