in membranes prepared from frontal cortex of rats receiving desmethylimipramine ( 10 mg/kg i.p . twice daily ) or imipramine ( 7.5 mg/kg i.p . twice daily ) for 3 weeks , the density of high-affinity gamma-aminobutyric acid ( gaba ) b recognition sites is increased when measured by [ 3h ] gaba binding in the presence of an excess of bicuculline , but it is unchanged when measured by [ 3h ] ( - ) -baclofen binding .
C0016904
gamma-aminobutyric acid
C0004609
baclofen