after acute administration of chlordimeform ( 100 mg/kg , ip one hr prior to sacrifice ) differential effects were observed in various parameters of the hepatic microsomal mixed function oxidase system with significant decreases in ethylmorphine metabolism , cytochrome p-450 content , nadph cytochrome c reductase , and in the spectral binding of hexobarbital and aniline while no changes were found in the metabolism of aniline or p-nitroanisole .
C0010762
cytochrome p-450
C0025519
metabolism