down-regulation of protein kinase c with prolonged phorbol ester ( 12-o-tetradecanoylphorbol 13-acetate ( tpa ] treatment leads to a refractory state in which the cells do not respond to pth ( 10 ( -8 ) m ) , camp ( 10 ( -4 ) m ) or rechallenge of tpa ( 200 nm ) even though na+/pi cotransport is similar to control cells ( 8.1 +/- 0.1 nmol.mg-1 protein.5 min-1 ) .
C0031586
phorbol ester
C0039654
12-o-tetradecanoylphorbol 13-acetate