moreover , aggregated human igg and its fc fragments ( but not monomeric igg and its fab fragments ) inhibited the mitogenicity of okt3 : their inhibition could be explained by stimulation of monocytes , resulting in increased prostaglandin e release , since ( a ) prostaglandin e2 itself strongly suppressed okt3 activity and ( b ) indomethacin blocked the inhibitory effects of aggregated huigg .
C0033559
prostaglandin e
C0012472
prostaglandin e2