the unbound fraction of both drugs fell with increasing albumin ( 10 to 60 g l-1 ) and alpha 1-acid glycoprotein ( 0.5 to 2.0 g l-1 ) concentration , and there was a marked increase in unbound fraction of qn ( 6 to 19 % ) and qd ( 13 to 36 % ) in human plasma when drug concentrations were increased over the antimalarial therapeutic range ( 0.5 to 10 mg l-1 ) .
C0034417
qn
C0034414
qd