the matrix vesicle protease had a mw of 33,000 and a ph optimum of 7.2 and was completely inhibited by 0.1 mm edta and 0.2 mm o-phenanthroline . alpha 2-macroglobulin , ovalbumin , cysteine , penicillamine , ethane-1-hydroxy-1 , 1-diphosphonate ( ehdp ) and pyrophosphate at higher concentrations were also inhibitory .
C0012544
diphosphonate
C0086268
ehdp