in microsomal incubations , metabolism of thio-tepa led to the inactivation of p-450 pb-4 ( steroid 16 beta-hydroxylase ) as well as p-450 iiia-related enzymes ( steroid 6 beta-hydroxylase ) and the p-450-independent enzyme steroid 17 beta-hydroxysteroid : nadp+ 17-oxidoreductase , as demonstrated by use of the p-450 form-selective steroidal substrate androst-4-ene-3,17-dione .
C0025519
metabolism
C0010762
p-450