the most potent compound , 2- [ [ 3- ( 1-hydroxyhexyl ) phenoxy ] -methyl ] quinoline ( 33 ) , had an i50 of 0.12 microm in the rat pmn 5-lo assay and an i50 of 3.6 microm in the leukotriene-induced contraction of gp lung parenchymal strips , and it also showed 91 % inhibition of srs-a-mediated bronchospasm in the gp in vivo at 10 mg/kg , administered intraduodenally .
C0023545
leukotriene
C0038091
of