the spontaneous cellular release of cleaved chromatin constituents in vitro can be attributed to a form of programmed cell death termed apoptosis , since the cultured spleen cells exhibited ( a ) morphologic evidence consistent with this process by electron microscopy , and ( b ) evidence of intracellular cleavage of chromatin which , like apoptosis , could be blocked with znso4 .
C0007634
cellular
C0162638
apoptosis