the data from earlier cytochemical studies , in which the metachromatic fluorochrome acridine orange ( ao ) was used to differentially stain single vs double-stranded dna , suggested that dna in situ in intact metaphase chromosomes or in condensed chromatin of g0 cells is more sensitive to denaturation , induced by heat or acid , than dna in decondensed chromatin of interphase nuclei .
C0019397
condensed chromatin
C0007634
cells