a single injection of 5,7-dihydroxytryptamine ( 5,7-dht , 75 micrograms icv ) or administration of p-chlorophenylalanine ( pcpa ; 200 mg/kg ) daily for 11-15 days produced 62-77 % reductions in brain 5-ht concentrations and marked supersensitivity of 5-ht2 receptor function , as indicated by the enhancement of the head-twitch response to 5-methoxy-n , n-dimethyltryptamine ( 2 mg/kg ) .
C0006104
brain
C0086045
concentrations