experiments in mice have shown that suprofen antagonizes abdominal stretching induced by the physiological precursor of pg release , arachidonic acid ( ed50 = 0.07 mg/kg , p.o . ) , and by the nociceptive agents acetylcholine ( ach ) ( ed50 = 1.7 mg/kg , p.o . ) , bk ( ed50 = 65 mg/kg , p.o . ) acetic acid ( hac ) ( h+ ion ; ed50 = 4.6 mg/kg , p.o . ) , and pge2 , itself ( ed50 = 20.2 mg/kg , i.p . ) .
C0033554
pg
C0012472
pge2