to explore the hypothesis that alkaline phosphatase ( alp ) functions in the regulation of cell growth and differentiation , we examined in tissue culture several parameters of cell proliferation demonstrated by dermal fibroblasts from patients with infantile hypophosphatasia -- a heritable form of rickets/osteomalacia which is characterized biochemically by marked deficiency of activity of the `` '' tissue nonspecific '' '' ( bone/liver/kidney ) alp isoenzyme .
C0035579
rickets
C0262950
( bo