nitrendipine depresses contractility in isolated feline cardiac muscle and canine coronary arteries in a dose-dependent manner [ half-maximal dose ( ed50 ) 0.20 microm in isolated feline cardiac muscle and 1.6-6.3 nm for potential dependent contractile responses in isolated canine coronary arteries ] and severely blunts the contractile response to increases in extracellular calcium concentration in isolated feline papillary muscles .
C0027061
cardiac muscle
C0030352
papillary muscles