the doughnut hypothesis of cytolysis by complement [ mayer , m. m. ( 1972 ) proc . nat . acad . sci . usa 69 , 2954-2958 ] describes an annular structure made up of c5b-9 ( complement factors c5b , c6 , c7 , c8 , and c9 ) which becomes inserted in the lipid bilayer of the cell membrane , thus creating a hole .
C1536403
cytolysis
C0007634
cell