if ircm-serine protease 1 participates in prohormone maturation in vivo , we propose a model in which this protease is present in an enzymatically active form in small vesicles , possibly within clathrin-coated structures ( prosecretory granules ) which are then transformed to mature secretory granules by a process which would also inactivate most of the enzyme .
C0030946
protease
C0014442
enzyme