to examine whether liposome-encapsulated aminoglycosides might kill intracellular mac more effectively in vivo , beige mice were infected with mac strain 101 ( serotype 1 ) and after 1 week were treated intravenously every other day ( 5 doses total ) with amikacin liposomes ( 0.2 , 1 , or 4 mg/dose ) , amikacin solution ( 0.2 , 1 , or 2 mg ) , gentamicin liposomes or gentamicin solution ( 0.2 or 1 mg ) , placebo liposomes ( without aminoglycosides ) , or buffer .
C0017436
gentamicin
C0002556
aminoglycosides