derivatives of glyoxal bis ( guanylhydrazone ) ( gbg ) , such as methylglyoxal bis ( guanylhydrazone ) and ethylglyoxal bis ( guanylhydrazone ) , are potent inhibitors of s-adenosylmethionine decarboxylase ( ec 4.1.1.50 ) , the key enzyme required for the synthesis of spermidine and spermine .
C0017992
glyoxal
C0034338
methylglyoxal