a single 8-h exposure of adult female wistar rats to 20 ppm carbon disulphide ( cs2 ) , the threshold limit value ( tlv ) in several countries , was sufficient to cause inhibition of the following drug-metabolizing reactions : formation of trichloroethanol and trichloroacetic acid from trichloroethylene ( aliphatic c-hydroxylation ) , formation of 4-hydroxyantipyrine from antipyrine ( quasi-aromatic c-hydroxylation ) , formation of acetaminophenol from acetanilid ( aromatic c-hydroxylation ) and phenacetin ( oxidative odealkylation ) , respectively , and formation of 4-aminoantipyrine from aminopyrine ( oxidative n-demethylation ) .
C0002696
aminoantipyrine
C0002586
aminopyrine