because prostacyclin and thromboxane a2 profoundly influence platelet function and vascular tone and are thought to be important in the development of atherosclerosis and angina pectoris , we studied the effects of hypothyroidism in rats on the in vitro elaboration of prostacyclin passively by aortic tissue and of thromboxane a2 by thrombin-stimulated whole blood .
C0003850
atherosclerosis
C0033567
prostacyclin