because of the potential of doxycycline-rifampicin for oral therapy of infectious diseases with intracellular bacteria , specially brucellosis and the well known cytochrome p450 enzyme system inductive activity of rifampicin , we may speculate that this antibiotic can altered the serum concentration-time profile of doxycycline when given in combination .
C0006309
brucellosis
C0035608
rifampicin