in brain tumor cooperative group study 77-02 , eleven institutions randomized 603 adult patients with supratentorial malignant glioma to one of four treatment groups following surgery : conventional radiotherapy ( 6000 cgy in 30-35 fractions ) + bcnu , conventional radiotherapy + streptozotocin , hyperfractionated ( twice daily ) radiotherapy ( 6600 cgy in 60 fractions ) + bcnu , and conventional radiotherapy with misonidazole followed by bcnu .
C0006118
brain tumor
C0007257
bcnu