it was found that in vitro both forward and reverse fluxes through creatine kinase at equilibrium were almost equal and very stable to changes in phosphocreatine/creatine ratio ( from 0.2 to 3.0 ) as well as to changes in ph ( from 7.4 to 6.5 or 8.1 ) , free mg2+ concentration and 2-fold decrease of total adenine nucleotides and creatine pools ( from 8.0 to 4.0 mm and from 30 to 14 mm , respectively ) .
C0031634
phosphocreatine
C0010286
creatine