the comparative study of the human tumor cell line hep-2 and rat liver for the detection of antinuclear and antinucleolar autoantibodies by the indirect immunofluorescence technic in routine screening test demonstrate that , taking titer and staining pattern into account , both substrates are able to separate autoimmune disease ( systemic lupus erythematosus , rheumatoid arthritis , scleroderma and primary biliary cirrhosis ) patients from healthy subjects .
C0004364
autoimmune disease
C0011644
scleroderma