the mtx and amt analogues with the ch2ch2cooh moiety replaced by a ch2ch = chcooh side chain showed anti-dhfr activity similar to that of the previously described saturated compound n- ( 4-amino-4-deoxy-n10-methylpteroyl ) -l-2-aminoadipic acid , but were less potent than the parent drugs .
C0025677
mtx
C0002583
amt