it is concluded that in thrombin-treated platelets ( 1 ) phosphatidate synthesis , but not phosphatidylinositol disappearance , is tightly coupled to receptor occupancy and acid hydrolase secretion in platelets , ( 2 ) successive phosphorylations to phosphatidylinositol-4,5-bisphosphate is unlikely to be the main mechanism for phosphatidylinositol disappearance , and ( 3 ) only a small fraction ( 15 % ) of phosphatidylinositol-4,5-bisphosphate is susceptible to hydrolysis .
C0020289
hydrolase
C0020291
hydrolysis