kinetic analysis of proinsulin processing by a mixture of trypsin and carboxypeptidase b ( to stimulate in vivo processes ) revealed ( a ) a rapid decline in proinsulin concommitant with formation of conversion intermediates , ( b ) formation of des-arg31 , arg32-proinsulin and des-lys64 , arg65-proinsulin in the ratio 3.3:1 at steady state , and ( c ) complete conversion of the precursor to insulin during extended incubation .
C0033362
proinsulin
C0021641
insulin