furthermore , in the former group of patients , recently recruited macrophages were significantly more frequent than in patients with low disease activity ( 11.6 +/- 4.0 versus 3.5 +/- 3.6 % , p less than 0.01 ) , and macrophages often displayed a markedly hypertrophied cytoplasm with numerous phagolysosomes , suggestive of an activated state .
C0010834
cytoplasm
C0031309
phagolysosomes