acute i.v . administration of bisoprolol ( 16-1024 micrograms.kg-1 ) did not affect mean arterial blood pressure but caused dose-related decreases in cardiac output ( from 8 to 17 % ; p less than 0.05 ) due to a negative chronotropic action ( heart rate reduction ranging from 9 to 21 % ; p less than 0.05 ) as stroke volume was unaffected .
C0053799
bisoprolol
C0428977
heart rate reduction