in 13 patients with long duration of iddm ( 9 +/- 0.5 yr , mean +/- sem ) and initially poor glycemic control ( mean diurnal blood glucose , mbg 199 +/- 8 mg/dl , ketoamine-hba1 12.4 +/- 0.2 % ; nondiabetic subjects 104 +/- 4 mg/dl and 6.8 +/- 0.09 % , respectively ) , rates of plasma glucose recovery from hypoglycemia ( 0.30 +/- 0.01 versus 0.60 +/- 0.01 mg/dl x min in nondiabetic subjects , p less than 0.001 ) and plasma glucagon ( auc 0.56 +/- 0.09 versus 6.3 +/- 0.50 ng/ml x 150 min in nondiabetic subjects , p less than 0.01 ) and epinephrine ( auc 16.9 +/- 0.2 versus 25.7 +/- 0.2 ng/ml x 150 min in nondiabetic subjects , p less than 0.001 ) responses to hypoglycemia were impaired .
C0020615
hypoglycemia
C0017687
glucagon