the extent of such stepwise deletions , resulting in loss of genes such as interleukin-3 ( il-3 ) , il-4 , il-5 , and gm-csf , whose gene products are critical to differentiation within the lineage of the affected hematopoietic stem cell , may be mirrored in the heterogeneity of symptoms and 5q- deletion sizes observed in myelodysplasias and acute leukemias carrying a 5q- chromosome .
C0079460
gm-csf
C0007589
differentiation