ro 22-4839 was found to more strongly inhibit the superprecipitation of chicken gizzard smooth muscle actomyosin ( ic50 = 2.0 mumol/l ) than trifluoperazine ( 38 mumol/l ) and w-7 ( n- ( 6-aminohexyl ) -5-chloro-1-naphthalene-sulfonamide ) ( 220 mumol/l ) , an in vitro model for relaxation-contraction coupling of the smooth muscle in which calmodulin is known to play an important role through phosphorylation of myosin light chain kinase .
C0031715
phosphorylation
C0027120
myosin