we ( 1 ) obtain cultured lymphocytes from effusion lymphocytes ( el ) or regional lymph-node lymphocytes ( rlnl ) , when possible , rather than peripheral blood lymphocytes ( pbl ) , ( 2 ) use crude il-2 to induce t cell proliferation and to maintain killer activity , ( 3 ) use sonicated autologous tumor extract as antigen ( ag ) to stimulate proliferation of cytotoxic t cells , and ( 4 ) pretreat the patients with local administration of ok-432 before ait to induce effector cells that act synergistically with transferred killer cells .
C0021756
il-2
C1155046
t cell proliferation