a human polyclonal igg ( pigg ) , previously characterized as anti insulin receptor antibody , able to inhibit insulin receptor kinase activity , was used to further investigate subunit homologies and differences in antigenicity and functional regulation between igf i and insulin receptors , igf i receptor tyrosine kinase was stimulated by a igf i analog ( aigf i ) , produced by dna recombinant technology , pigg was able to inhibit igf i receptor kinase activity , thus revealing antigenic homologies between the kinase domains of insulin and igf i receptors .
C0033681
tyrosine kinase
C0031727
kinase