however , the data suggest that the cleavage of hmg-coa is at least partially reversible and indicate that enolization of acetyl-coa may be dependent upon a conformational change of hmg-coa lyase , induced by binding of acetoacetate , in a manner analogous to the keto acid dependent tritium exchange catalyzed by malate synthase and citrate synthase .
C0000988
acetoacetate
C0022618
keto acid