to examine whether a single infusion of human recombinant tnf alpha ( rtnf alpha ) reproduces the pulmonary effects of endotoxemia , we infused rtnf alpha ( 0.01 mg/kg ) over 30 min into six chronically instrumented awake sheep and assessed the ensuing changes in hemodynamics , lung lymph flow and protein concentration , and number of peripheral blood and lung lymph leukocytes .
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peripheral blood
C0023516
leukocytes