when orally administered to genetically obese and diabetic yellow kk mice ( 2.4-24.5 mg/kg/d ) , and zucker fatty rats ( 0.1-10 mg/kg/d ) for 4 days , pioglitazone markedly decreased hyperglycemia , hyperlipidemia , hyperinsulinemia , and glucose intolerance characterized as insulin resistant states in these animals .
C0020456
hyperglycemia
C0021641
insulin