since na , k-atpase-mediated ion transport is the major consumer of metabolic energy in the kidney and is centrally important to renal function , it is suggested that the early and pronounced increase in renal na , k-atpase seen in diabetes is an essential component of the renal hypertrophy and hyperfunction seen in this disease and may represent an important adaptive change in the kidneys in response to glucose osmotic diuresis in the experimental diabetic animals .
C0156259
renal hypertrophy
C0022646
kidneys