in addition to the above findings , immunocytochemical study with anti-insulin serum demonstrated that the staining intensity of the beta cell cytoplasm became weaker ( as judged by light microscopy ) from the fifth week , but large cytoplasmic vacuoles were stained positively under both the light microscope ( pap method ) and the electron microscope ( enzyme-labelled antibody method ) .
C0007634
the
C0042219
vacuoles