monocrotaline-treated rats exhibited dose-dependent increases in ( 1 ) pulmonary histopathology , ( 2 ) pulmonary endothelial dysfunction ( decreased lung plasminogen activator activity , and increased prostacyclin and thromboxane production ) , ( 3 ) pulmonary hydroxyproline ( collagen ) content , and ( 4 ) cardiac right ventricular hypertrophy ( an anatomic correlate of pulmonary hypertension ) .
C0033567
prostacyclin
C0020542
pulmonary