verapamil ( 2.5 mug/ml ) also antagonized cyclic amp-induced vascular relaxations.5 the vasodilator effect of verapamil was inhibited dose-dependently by raising the concentration of extracellular ca ( 2+ ) from 0.05 to 0.2 g/l ( or 1.25 to 5.0 mm ) while those elicited by glucagon or cyclic amp were not influenced , thus suggesting that the latter two drugs do not interfere with ca ( 2+ ) influx.6 disodium edetate ( na ( 2 ) edta , 210 to 840 mug/l ) produced a dose-dependent vasodilator effect which was attributed to the facilitation of ca ( 2+ ) extrusion from the smooth muscle cells and/or ca ( 2+ ) binding to the cell membrane .
C0012695
disodium edetate
C0013618
edta