it is concluded that in rabbit aortic rings 5-ismn , the major metabolite of isdn , is not an antagonist of isdn at a `` '' nitrate receptor , '' '' and no support is provided for the hypothesis that the accumulation in plasma of metabolites ( e.g. , 5-ismn ) with longer half-lives than the parent drug explains tolerance to organic nitrates .
C0022252
isdn
C0064079
, 5-is