however , the specific involvement of the igf-ii receptor in the modification of the iap substrate induced by low concentrations of igf-ii was suggested by the observations that ( i ) igf-i receptor-lacking cell membranes were effective for the gi2 modification by igf-ii , ( ii ) the ability of membranes to mediate the action of igf-ii was markedly attenuated in igf-ii receptor-lacking cell membranes , and ( iii ) agonistic anti-igf-ii receptor antibody mimicked the action of igf-ii on the 40-kda protein in balb/c3t3 cell membranes in a dose-dependent manner similar to that observed in the antibody-induced blocking of membrane igf-ii binding .
C0140079
igf
C0007603
cell