several lines of evidence , which showed that striatal levels of [ met5 ] enkephalin ( me ) increase after the nigrostriatal dopaminergic pathway was interrupted by hemitransection or direct administration of 6-hydroxydopamine to the substantia nigra , or after repeated injections of either reserpine or haloperidol , suggest that dopamine ( da ) plays an important role in regulating the metabolism of me-containing neurons in the striatum .
C0282151
dopaminergic
C0013030
dopamine