bound ligand dissociation from this soluble complex was similar to that from the membranous receptors of origin and the marked increase in the rate of dissociation induced by gtp was preserved in the soluble state , indicating that the solubilized cck receptors remained functionally coupled with the guanine nucleotide regulatory site modulating the affinity for cck .
C0018353
gtp
C0018328
guanine nucleotide