a pharmacokinetic study using theophylline syrup in adult asthmatic patients demonstrated a mean apparent volume of distribution of 0.38 liters/kg , mean elimination rate constant of 0.10 hours-1 , and variable rates of clearance of theophylline ( total body clearance of 0.38 to 0.96 ml/kg per minute ) .
C0004096
asthmatic
C0039771
theophylline