to evaluate the renal effects of nisoldipine ( n ) , a dihydropyridine derivative , we have evaluated the variations of blood pressure ( bp ) , heart rate , glomerular filtration rate ( gfr ) , renal plasma flow ( rpf ) , 24-h natriuresis , and renal capacity to excrete an i.v . sodium load ( 2,000 ml isotonic saline in 4-h ) in response to a 4-day course of therapy with placebo ( p ) and n in six normotensive volunteers and six mild-to-moderate essential hypertensive patients .
C0028116
nisoldipine
C0012315
dihydropyridine