in other studies , we have established that heme oxygenase blockade by sn-protoporphyrin leads to a marked and rapid excretion of heme into bile presumably because the synthetic metabolism to bile pigment and making it available for excretion via the biliary system in to the gut , these studies strongly suggest that sn-protoporphyrin diminishes hyperbilirubinemia in animals and man by inhibiting the production of the bile pigment in vivo , and that its principal mode of action involves a potent and sustained competitive inhibition of heme oxygenase .
C0025519
metabolism
C0221102
excretion