in order to evaluate the in vivo effects of biguanides on the insulin receptor , we have studied insulin binding to circulating monocytes of six normal controls , eight obese nondiabetic subjects , and six obese type ii diabetic patients , both before and after 4 days of treatment with the biguanide metformin ( 850 mg twice daily orally ) .
C0005382
biguanide
C0025598
metformin