in a controlled clinical trial , 52 patients with er positive metastatic breast cancer were randomly assigned to receive initial treatment with either tamoxifen alone followed by sequential cyclophosphamide , methotrexate , and 5-fluorouracil ( cmf ) after tumour progression of concurrent tamoxifen plus cmf , all 52 patients entered are eligible and 50 patients were currently assessable .
C0016360
5-fluorouracil
C0950521
cmf