in rats with experimental hypertension , enalapril was most potent in those models in which the renin-angiotensin system plays a dominant role ( salt restriction , two-kidney grollman ) and in models rendered renin dependent by diuretics , although blood pressure reduction did occur in low or normal renin models such as spontaneously hypertensive rats , in which inhibition of ace as measured by the blockade of angiotensin i pressor responses bore little temporal relationship to the later fall in blood pressure after enalapril .
C0020649
blood pressure reduction
C0014025
enalapril