5ht secretion induced by the protein kinase c ( pkc ) activator , phorbol 12-myristate 13-acetate ( pma ) , was also not affected by rgds , but proteolytic degradation of the translocated membrane-bound enzyme in pma-treated platelets , due to the actions of the ca2+-dependent protease ( ca-dp ) , was completely prevented such that in the presence of rgds , sustained increases in membrane-bound pkc activity were observed .
C0030940
proteolytic
C0030946
protease