in rats of groups a and b , killed at 1 , 2 , 4 , and 6 hours , progressive liver changes included intravascular sequestration of rapidly degranulating leukocytes , fibrinous deposits , and platelet aggregates in sinusoids as well as in spaces of disse adjacent to subendothelial collagen , and extensive kupffer cell disruption in association with severe midzonal necrosis .
C0023884
liver
C0227530
spaces of disse