in a randomized , double-blind crossover trial , indapamide ( ind ) 2.5 mg and hydrochlorothiazide 25 mg + amiloride 2.5 mg ( hctz + a ) were found to be equally effective in reducing blood pressure ( bp ) in 13 patients with moderate to severe hypertension already receiving chronic treatment with a beta blocker and a vasodilatator ( supine bp during run-in : 169/103 +/- 21/5 mmhg ;
C0002502
amiloride
C0020538
hypertension