electron-microscopic examinations of the epidermis in 11 patients suffering from xeroderma with autosomal dominant and x-recessive inheritance have revealed changes in the basal membrane , scarce pinocytotic vesicles near the basal membrane , inter- and intracellular edemas in the epidermis , a decrease of the desmosomal contacts and an increased number of microvilli on the epidermocytes of the basal and prickle-cell layers , condensation of the nucleoplasm , reduced counts of organelles and condensation of the epidermocyte tonofilaments , hyperkeratosis , and an elevated count of the desmosomes in the horny layer in both forms of ichthyosis .
C0014520
epidermis
C0221921
horny layer