as part of a program in which we are attempting ( a ) to delineate the structural features at positions 1-9 in our previously reported antidiuretic antagonists required for antidiuretic antagonism and ( b ) to obtain analogues with enhanced antiantidiuretic potency and/or selectivity , we have synthesized 14 new analogues of the antidiuretic antagonist [ 1- ( beta-mercapto-beta , beta-cyclopentamethylenepropionic acid ) ,2-d-phenylalanine,4-valine ] arginine-vasopressin [ d- ( ch2 ) 5-d-phe2vavp ) , in which the valine residue at position 4 was replaced by the following l-amino acids and glycine : ile , abu , thr , ala , gln , lys , cha , nle , nva , phe , leu , gly , tyr , and pro .
C0002520
amino
C0017890
gly