continuous subcutaneous infusion into pregnant rats from the 9th-20th day of gestation of either ( 1 ) phenylacetate ( pa ) , to elevate plasma levels of unconjugated pa to 0.25-0.60 mumol/ml , or ( 2 ) a nontoxic dose ( 0.2 mumol/g/day ) of p-chlorophenylalanine ( pclphe ) with l-phenylalanine ( phe ) , to elevate plasma phe levels at least 10-fold ( 1.7-2.3 mumol/ml ) and unconjugated pa to at least 0.2 mumol/ml , produced the syndrome of untreated maternal pku : spontaneous abortion , mortality rate greater than normal among the newborn , retarded growth of fetal body and brain , and a learning deficit among the progeny .
C0030135
p-chlorophenylalanine
C0031453
phenylalanine