normally , the injection of streptozotocin ( stz ) at a lower dose ( 60 mg/kg body weight ) to young ( 45 days old ) cd-1 male mice produces a sustained hyperglycemia with the concomitant development of hypoinsulinemia and immune insulitis in the pancreas , both of which lead to insulin-dependent diabetes ( idd ) .
C0030274
pancreas
C0011854
insulin-dependent diabetes