in the remaining two patients , one of whom is known to carry a mutation in the small intron of the beta-globin gene , accumulation of large 3h beta-intron rna and beta-globin [ 3h ] mrna was normal in nuclei , but the ratio of beta/alpha [ 3h ] mrna in cytoplasm was reduced , suggesting a different posttranscriptional defect in beta-mrna processing .
C0035668
rna
C0035696
mrna