an rnr2-lacz fusion was used to further characterize the regulation of rnr2 and the pathway responsible for its response to dna damage . beta-galactosidase activity in yeast strains containing the rnr2-lacz fusion was inducible in response to dna-damaging agents ( uv light , 4-nitroquinoline-1-oxide [ 4-nqo ] , and methyl methanesulfonate [ mms ] ) and agents that block dna replication ( hydroxyurea [ hu ] and methotrexate ) but not heat shock .
C0012854
dna
C0598312
dna replication