in order to test whether co-administration of a serotonin precursor with antidepressant drugs could potentiate the effects of the antidepressants on monoamines or adrenoceptors in rat brain , l-tryptophan ( 20 mg/kg ) was administered to rats daily for 7 or 15 days , either alone or in combination with desipramine ( 10 mg/kg ) or amitriptyline ( 10 mg/kg ) .
C0003289
antidepressants
C0011685
desipramine