the effect of indometacin on coronary flow rate and consequently on myocardial tissue oxygenation was completely prevented by the preferential 5-lipoxygenase inhibitor nordihydroguaiaretic acid ( ndga ) ( 1 x 10 ( -6 ) mol/l ) , or the sulfidopeptide leukotriene receptor antagonist fpl 55712 ( 2 x 10 ( -5 ) mol/l ) , indicating that the isolated working guinea pig heart , even when deprived of blood , is able to produce vasoactive sulfidopeptide leukotrienes at significant levels .
C0027061
myocardial
C0018787
heart