fourth , the in vitro metabolism of isosafrole , catalyzed by hepatic microsomes from rats treated with 2,3',4,4',5,5'-hexachlorobiphenyl , isosafrole or 3-methylcholanthrene , produced complexes between ferrous cytochrome p-450 and a methylenedioxyphenyl metabolite , the spectra of which were between 400 and 500 nm and were similar to each other but which were readily distinguishable from the spectra of the product adducts formed during the metabolism of isosafrole by hepatic microsomes from rats treated with corn oil ( control ) , phenobarbital , or pregnenolone-16 alpha-carbonitrile .
C0010762
cytochrome p-450
C0025519
metabolism