insulin resistance , as it occurs in obese or obese-diabetic humans and animals , is most often associated with hyperinsulinemia , and is characterized not only by increased activity of key-enzymes of pathways known to be stimulated by insulin ( glycolysis , lipogenesis ) , with the possible exception of glycogen synthesis , but also by a trend towards increased activity of key-enzymes of 'catabolic pathways ' , normally depressed by insulin .
C0017952
glycolysis
C0021641
insulin