significant beta-blockade , as demonstrated by reduction in heart rate during exercise in healthy subjects , persists for at least 24 hours after penbutolol administration , and thus the recommended dosage schedule in both hypertension and angina involves single daily doses ( 20 or 40mg daily ) in most patients , with a divided dose ( 40mg twice daily ) if a higher dose is needed .
C0030812
penbutolol
C0002962
angina