rats treated with two classic neuroleptic drugs at therapeutic doses , haloperidol ( 0.05 mg/kg/day i.p . ) and sulpiride ( 3 mg/kg/day i.p . ) showed a marked decline in cerebral levels of insulin ( 0.085 +/- 0.02 ng/g and 0.120 +/- 0.04 ng/g wet weight respectively ) compared to the control group ( 0.383 +/- 0.05 ng/g wet weight ) , while rats given d-amphetamine bitartrate chronically ( 20 mg/kg/day p.o . ) showed an increase in cerebral insulin ( 0.55 +/- 0.04 ng/g wet weight ) .
C0040615
neuroleptic drugs
C0018546
haloperidol