bilateral orchidectomy in this experimental paradigm elicited only small increments in lh pulse amplitude and mean plasma lh concentration , a response in striking contrast to the dramatic postcastration lh hypersecretion observed in animals with intact hypothalami that respond to the opening of the negative feedback loop with an apparent acceleration in the endogenous frequency of intermittent gnrh secretion .
C0020663
hypothalami
C0023610
gnrh