these results suggest that radiosensitization and direct killing by misonidazole are two distinct phenomena mediated by different cellular mechanisms , and radiosensitization by misonidazole represents a two-component effect composed of true dose modification and dose additive damage interactions , but these additive effects must occur at a site different from the cellular structure responsible for direct drug-induced cell death .
C0007634
cellular structure
C0007587
cell death