the development of dialysis cannula techniques coupled with high performance liquid chromatography and electrochemical detection ( hplc-ec ) has provided a means to continuously sample extracellular fluid from deep brain structures in vivo . the present studies show that with hplc-ec analysis of the acid metabolites of dopamine ( da ) and 5-hydroxytryptamine ( 5-ht ) in samples from dialysis cannulae implanted in the caudate nucleus of anaesthetized rats , it is possible to determine the time course of the response of dopamine- and 5-ht containing neurones to administration of monoamine oxidase inhibitors and haloperidol .
C0006104
brain structures
C0007461
caudate nucleus