in order to learn whether the neonatally thymectomized lewis rat ( ntlr ) infected with mycobacterium leprae could serve as a model for chemotherapeutic studies in a situation resembling that found in human lepromatous leprosy , ntlr inoculated with m. leprae either locally or intravenously 9 to 16 months earlier were treated for from 1.5 to 8.5 months with dapsone ( 4,4'-diaminodiphenylsulfone , dds ) incorporated in the rat chow in the concentration providing the minimal inhibitory concentration of the drug for m. leprae and in the 100-fold larger concentration .
C0023348
lepromatous leprosy
C0010980
diaminodiphenylsulfone