these observations support the interpretations that a ) differentiated keratinocytes have a higher capacity in the metabolic activation of pah than do germinative cells , although both types of cell are susceptible to induction of cytochrome p-450 by exposure to ba , and b ) the cytochrome p-450 induced by exposure of epidermis to benz ( a ) anthracene in vivo exhibits some differences from the one induced upon exposure of keratinocytes to this procarcinogen in vitro .
C0007589
differentiated
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cells