a variety of bisphosphonates with aliphatic side chains of increasing length , as well as 3-amino-1-hydroxypropylidene-1,1-bisphosphonate ( ahprbp , formerly apd ) , dichloromethylene-bisphosphonate ( cl2mbp , formerly cl2mdp ) , and dibromomethylene bisphosphonate ( br2mbp , formerly br2mdp ) , were compared in vitro and in vivo to find ( a ) a possible relationship between structure and activity in order to give some indication about their mechanism ( s ) of action on bone and ( b ) the most efficient and safe compound having an effect on bone resorption .
C0012544
bisphosphonates
C2267018
bisphosphonate