we suggest that the primary abnormality in this syndrome increases the reabsorptive avidity of the distal nephron for chloride , which ( 1 ) limits the sodium and mineralocorticoid-dependent voltage driving force for potassium and hydrogen ion secretion , resulting in hyperkalemia and acidosis and ( 2 ) augments distal sodium chloride reabsorption resulting in hyperchloremia , volume expansion , hyporeninemia , and hypertension .
C0008203
chloride
C0037494
sodium