stable transfection of three human tumor cell lines -- h-ras-transformed bronchial epithelial cells tbe-1 , fibrosarcoma cells ht1080 , and melanoma cells a2058 -- with the adenovirus e1a gene dramatically repressed the expression of the secreted proteases , type iv and interstitial collagenases , and urokinase-type plasminogen activator .
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cells
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secreted