although our data are consistent with dunn & heath 's proposal ( 1976 ) that the inflexibility of the cytoskeleton of a moving cell 's protrusion is the cellular property determining such reactions to topography , we have found that , on encountering a topographical feature , the response of a cell may be predictable on a probabilistic basis , i.e . the topographical feature reduces the probability of a cell making a successful protrusion and contact in a given direction , that even the largest features tested did not act as absolute barriers to cell locomotion since a small proportion of a population of cells were able to overcome them , and that other guidance cues could significantly alter a cell 's response .
C0010853
cytoskeleton
C0007634
cell 's