we have recently reported that neolacto series gangliosides ( neuac-nlc ) are increased during granulocytic differentiation of human myelogenous leukemia cell line hl-60 cells induced by retinoic acid and that hl-60 cells are differentiated into mature granulocytes when the cells are cultivated with neuac-nlc ( nojiri , h. , kitagawa , s. , nakamura , m. , kirito , k. , enomoto , y. , and saito , m. ( 1988 ) j. biol . chem . 263 , 7443-7446 ) .
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