aging appeared to result in a generalized widening of the stromal layer from 19.3 +/- 2.4 microns ( 10-20 years ; n = 4 ) to 60.0 +/- 11.5 microns ( 80-90 years ; n = 3 ) in ciliary processes and from 53.0 +/- 6.8 microns to 107.6 +/- 15.2 microns in the ground plate between ciliary valleys and ciliary muscle , a density increase of collagenous fibers from 39.3 +/- 4.9 to 83.5 +/- 14.6 fibers/microns 2 and a concomitant decrease in mean fiber diameter from 62.8 +/- 3.4 nm to 55.7 +/- 1.5 nm , a decline of stromal cell density from 31.4 +/- 1.8 to 9.6 +/- 1.0 cells/0.014 mm2 , a progressive thickening of the inner and outer limiting membranes from 0.8 +/- 0.4 micron to 8.1 +/- 1.5 microns and 2.1 +/- 0.6 microns to 4.5 +/- 0.5 microns respectively as well as the endothelial basement membrane from 0.13 +/- 0.004 micron to 0.25 +/- 0.03 micron , a gradual widening of the perivascular space between capillaries and overlying pigment epithelium from 6.2 +/- 1.5 microns to 11.3 +/- 2.9 microns , an increase in number of fenestrations in the capillary endothelium from 39.0 +/- 8.5 to 69.0 +/- 7.0 pores/100 microns , and finally a continuous augmentation of degenerative elements including lipids , lipofuscin granules , and lysosomes from 1.5 +/- 0.06 % to 7.2 +/- 0.6 % within the non-pigmented epithelium ( npe ) over the 71-year period studied .
C0007634
cells
C0024369
lysosomes