to test directly whether these base substitutions can result in an increase in a gamma-globin gene transcription , we studied cosmid clones containing the g gamma- through beta-globin gene regions from individuals with greek-type ( g-to-a base substitution at -117 ) and chinese-type ( c-to-t base substitution at -196 ) a gamma hpfh in a transient expression assay .
C0017033
gamma-globin
C0005221
beta-globin