an antibody directed toward pepleomycin , a new antitumor antibiotic related structurally to bleomycin , has been produced in rabbits by immunization with a pepleomycin-protein conjugate which was prepared by a novel procedure of coupling pepleomycin to mercaptosuccinylated bovine serum albumin using n- ( gamma-maleimidobutyryloxy ) succinimide as a coupling agent .
C0020971
immunization
C0184661
procedure