pre-incubation of neutrophils with pertussis toxin inhibited the synthesis of 5-lipoxygenase products induced by arachidonic acid by 75 % or more , but had no effect on either arachidonic acid-induced synthesis of the 15-lipoxygenase product , 15-hydroxyeicosatetraenoic acid , or activation of the 5-lipoxygenase induced by the calcium ionophore a23187 .
C0003692
arachidonic acid
C0220781
synthesis