these results indicate that 1 ) endogenous adenosine mediates metabolic vasodilation in the heart , 2 ) adenosine modulates the response of isolated myocardium to catecholamines , 3 ) myocardial adenosine formation appears to be linked to cytosolic metabolism via changes in [ atp ] / [ adp ] [ pi ] and [ amp ] , and 4 ) endogenous adenosine provides a significant , metabolically beneficial action in isolated hearts during hypoxia and inotropic stimulation .
C0027061
myocardial
C0018787
hearts