in vitro studies in exponentially growing l1210 cells utilizing dna flow cytometry and cell proliferation measurements indicate enhancement of methotrexate effects by dipyridamole provided : methotrexate concentrations exceed those required to shut off maximally de novo pathways of purine and pyrimidine synthesis ( i.e . 30 nm for 48 h ) , and dipyridamole concentrations exceed 3 microm .
C0007634
cells
C0596290
cell proliferation