these findings along with the significant tsh elevation , the reduction in colloid and in serum t3 and t4 , the efficacy of the hypothalamo-pituitary-thyroid feedback system , and previous observations of reduced iodine uptake and intrathyroidal t4 , suggested that primary hypothyroidism in the hyt/hyt mouse might be due to a defect in tsh responsivity of the thyroid gland .
C0700502
primary hypothyroidism
C0040132
thyroid gland