four patients with b-cell malignant diseases ( iga myeloma , macroglobulinemia , chronic lymphocytic leukemia , and b-cell lymphoma , respectively ) and acquired c1-inhibitor deficiency were found to have circulating antiidiotypic antibodies to the monoclonal immunoglobulin expressed on the surface of their b cells ( three patients ) or in the cytoplasm of their bone-marrow cells ( one patient ) .
C0004561
b-cell
C0024419
macroglobulinemia