this concept affords a comprehensive explanation of the following unresolved data recorded in goitrous areas : ( 1 ) clinical and biochemical discrepancies between subjects living in the same morbid territory , ( 2 ) persistence of endemicity in spite of appropriate iodine supplementation , ( 3 ) similar prevalence of goiter hypertrophy in male and female prepubertal children , ( 4 ) increased frequency of goiter enlargement in the four most vulnerable groups , namely preschool children of both sexes , adolescent girls , pregnant women , and elderly persons , ( 5 ) decreased impact of thyroid swelling accompanying improved socio-economic status , even without iodine addition , and ( 6 ) resurgence of goitrous hyperplasia as an effect of seasonal or sporadic deterioration of nutritional habits , even when iodine supply remains unchanged .
C0018021
goiter
C0040132
thyroid