as cd20 , cd21 , cd22 and membrane immunoglobulin change during or after b-cell activation , and the cd45ra/cd45ro inversion is implicated in t-cell maturation , the possibility that the phenotypic differences are generated by a maturational diversity of the cll clones has been investigated by testing the effects of tpa treatment of the leukaemic cells .
C1515126
t-cell maturation
C0007634
the