calcium-free perfusion promptly ( less than 5 min ) decreased the levels of polyamines and the activity of their rate-regulating synthetic enzyme , ornithine decarboxylase ( odc ) , and calcium reperfusion abruptly ( less than 15-180 s ) increased these components . alpha-difluoromethylornithine ( dfmo ) , a specific suicide inhibitor of odc , suppressed the calcium reperfusion-induced increase in polyamines and the concomitant increase in myocardial cellular 45ca influx , loss of contractility , release of cytosolic enzymes , myoglobin , and protein , and structural lesions .
C0029282
ornithine decarboxylase
C0002260
alpha-difluoromethylornithine