initially ( step 1 ) there was proteolytic cleavage of the protein core and partial endoglycosidic cleavage of the heparan sulfate chains ( t1/2 approximately 6 h ) , with generation of larger glycosaminoglycan-peptide intermediates with chains of mr approximately 10,000 , about one-third their original size .
C0019143
heparan sulfate
C0017973
glycosaminoglycan