this double-blind , parallel group multicentre study in 85 hospital out-patients with mild to moderate acne evaluated the efficacy of 2.2 mg/ml topical tetracycline or placebo applied twice daily for 16 weeks together with an initial course of oral tetracycline , at doses of 1000 mg/day during weeks 1-4 and 500 mg/day during weeks 5-8 .
C0001144
acne
C0039644
tetracycline