these findings support both pathogenetic mechanisms suggested in the literature , namely : the ability of leptospires to penetrate actively between cells with detachment of tight junctions , without obvious lesions to the cells , and an immune-mediated process with immune complex formation and binding and activation of complement resulting in leukocytosis , thrombotic glomerulopathy , endothelial alteration and haemorrhages .
C0242358
tight junctions
C0007634
cells