impairment of renal function also reduced total plasma protein binding : 58.2 +/- 5.0 % in healthy subjects and 31.8 +/- 3.9 % , 44.5 +/- 5.0 % , and 42.5 +/- 5.6 % , respectively , for the three renal patient groups .
C0035078
impairment
C0022646
renal