forward walking was inhibited by high doses of haloperidol or clozapine and potentiated by methergoline , mianserin or methysergide , suggesting that hyperactivity may also be mediated by dopamine but subject to 5-ht inhibition.7 abortive grooming was the dominant behavioural component observed after pea administration and was prevented by all of the antagonists tested which suggests that catecholamine and 5-ht mechanisms may be involved in the expression of this response.8 since pea is an endogenous compound in animals and man , and has been claimed to be present in abnormal amounts in some schizophrenics , pea-induced behavioural stimulation in mice ( which includes the postulated hallucinogenic responses of abortive grooming and backward walking ) may be a useful animal model of psychosis .
C0018546
haloperidol
C0033975
psychosis