the lung content of protein , proline , and hydroxyproline ( collagen ) were quantitated , as were the synthesis rates of lung collagen and the total lung protein ( evaluated with lung minces in vitro . the ratio of newly synthesized and of total lung type i to type iii collagen was also determined . these experiments were performed in parallel on rats free of chronic respiratory disease and a strain of conventional animals . the authors conclude that 1 ) the excess collagen deposited in granulomas and/or silicotic nodules as part of the fibrotic response of the lung is similar to normal lung collagen with respect to relative ratios of types i and iii present , in contrast to the response of the lung to oxidant pneumotoxins ;
C0037116
silicotic
C0024109
lung