in vitro culture of human peripheral blood lymphocytes with the beta-adrenergic catecholamine isoproterenol for 24 hours , induced homologous beta-adrenergic desensitization , i.e . a large decrease in the number of beta-adrenergic binding sites and loss of the adenylate cyclase response to isoproterenol , without altering the effectiveness of prostaglandin e1 to stimulate the enzyme .
C0007412
catecholamine
C0022245
isoproterenol