2 ) it may be established on absolute criteria ( isolation of the organism at the site of the lesions ) or , in the absence of direct bacteriological evidence , by a body of evidence amongst which 4 arguments are of particular value : identification of a pathogenic organism in one or more blood cultures and/or at the site of a closed infection , postive serology and particularly elevation of the antistaphylolysine titres , rapid-onset radiological changes of destruction and/or reconstruction . plus hypercellularity of the fluid greater than 100,000 cells/mm3 .
C0029235
organism
C0450254
pathogenic organism