the fact that the rate constants for inactivation of cell surface and total cellular insulin receptors were identical in the up-regulated state ( 0.046 and 0.044 h-1 , respectively ) or in the down-regulated state ( 0.10 and 0.096 h-1 , respectively ) suggests that the rate-limiting step in the receptor inactivation pathway occurs at the cell surface .
C0007634
cellular
C0699040
cell surface