in the presence of reductant nicotineamide adenine dinucleotide ( nadh ) or nicotineamide adenine dinucleotide phosphate ( nadph ) and organic substrate , aniline , hemin activates oxygen to the hydroperoxide anion ( ho2- ) and subsequently mediates insertion of active oxygen into the benzene ring of the substrate to form p-aminophenol , with a high degree of regiospecificity .
C0031603
phosphate
C0003075
anion