a situation of limited oxygen availability resulted in two different kinds of adaptation of the neuroblastoma cells : first an instantaneous metabolic regulation leading to an increased glycolytic rate-the pasteur effect-followed later by an increase in the activities of the glycolytic enzymes-hexokinase ( ec 2.7.1.1 ) , phosphoglucose isomerase ( ec 5.3.1.9 ) , 6-phosphofructokinase ( ec 2.7.1.11 ) , pyruvate kinase ( ec 2.7.1.40 ) and lactate dehydrogenase ( ec 1.1.1.27 ) and a simultaneous decrease of the mitochondrial cytochrome c oxidase ( ec 1.9.3.1 ) activity .
C0030016
ec
C0022917
lactate dehydrogenase