chronic treatment with the tumor-promoting phorbol esters 12-o-tetradecanoylphorbol-13-acetate ( tpa ) and 12-o-retinoylphorbol-13-acetate ( rpa ) causes permanently increased levels of active collagenolytic enzymes in the dermis and leads to a stable reduction of dermal collagen content .
C0031586
phorbol esters
C0039654
12-o-tetradecanoylphorbol-13-acetate