long-term administration of the antidepressant drug , desipramine ( 20 mg/kg/day , orally for 28 days ) , decreased the stimulatory effect of the alpha 2-adrenoceptor agonist , clonidine ( 250 micrograms/kg , i.p . ) on thyrotropin ( tsh ) secretion in the rat , but did not alter basal tsh secretion . beta-adrenoceptor-mediated inhibition of tsh secretion by isoproterenol ( 1 mg/kg , i.p . ) was unaffected by chronic desipramine treatment , as were the stimulatory effect of tsh-releasing hormone ( trh , 5 micrograms/kg , i.v . ) on tsh release and its inhibition by the alpha-adrenoceptor antagonist , phentolamine ( 2 mg/kg , i.p . ) .
C0003289
antidepressant drug
C0011685
desipramine