experimental dose-effect relationships of carcinogens following either acute ( single dose ) or chronic ( time to tumor ) exposure appears to conform with the median-effect principle ( chou , j. theor . biol . 59 , 253-276 , 1976 ) of the mass-action law : f ( a ) / ( 1 - f ( a ) ) = ( d/d ( m ) ) m , where d is dose or cumulative dose , d ( m ) is the d required for the median-effect , m is the hill-type coefficient , and f ( a ) is the fraction that is affected by d .
C0027651
tumor
C0577559
mass