we used antisera from patients with the crest syndrome of scleroderma ( calcinosis , raynaud 's phenomenon , esophageal dysmotility , sclerodactyly , telangiectasia ) to show that an antigenic component of the kinetochore present in metaphase chromosomes is also present in nonhistone chromosome scaffolds isolated following extensive digestion of the dna and extraction of the bulk of chromosomal protein .
C0206138
crest syndrome
C0006663
calcinosis