to test the hypothesis that a locus in or near the human major histocompatibility complex ( hla ) contributes to both involuntary fetal loss and neural tube defects ( ntd ) , we evaluated sharing of antigens of the hla-a , hla-b , or hla-dr loci of couples who had three or more first-trimester spontaneous abortions or who had a child with an ntd ( myelomeningocele or anencephaly ) .
C0027794
ntd
C0002902
anencephaly