the hypothesis that defective cell wall synthesis seems to represent a final common pathway of drug-induced injury either within the bacterial cell or on its surface was supported by two different findings : ( 1 ) sulfamethoxazole and trimethoprim , either alone or in combination , induced morphological findings in various escherichia coli and proteus mirabilis strains identical to those found after incubation with so-called cell-wall-active antibiotics ( e.g. , penicillin ) and ( 2 ) cell-wall-defective bacteria ( l forms , spheroblasts ) were resistant to sulfonamides and/or trimethoprim as compared to their normal bacterial cells .
C0038689
sulfamethoxazole
C0038760
sulfonamides