dna single-strand and double-strand breaks produced by doxorubicin and two anthracycline derivatives ( 4-demethoxy-daunorubicin and 4'-deoxy-4'-iododoxorubicin ) were measured in doxorubicin-sensitive and -resistant p388 leukemia cell lines , using filter elution methods , and compared with cellular drug accumulation to account for major differences in their cytotoxic activities and cross-resistance .
C0011015
daunorubicin
C0013089
doxorubicin