because pma and a23187 together bypass the early activation pathways and promote t-cell growth through the direct induction of membrane interleukin 2 ( il-2 ) receptor expression and il-2 synthesis and secretion , it could reasonably be hypothesized that the faulty ds t-cell activation induced by antigen or mitogen is due to a deranged transmembrane signal transduction , rather than a defect in the later intracellular events .
C1155065
t-cell
C0003320
antigen