useful models , whose study may lead to the clarification of this important point , are represented by premalignant conditions , such as the myeloproliferative disorders , where chromosome abnormalities are present before the development of a bona fide neoplasm , and by the aneuploidy syndromes , in which there exists an association between a constitutional chromosome anomaly and an increased risk of cancer .
C0002938
aneuploidy
C0008626
chromosome anomaly