the antiandrogens , cyproterone ( 1,2 alpha-methylene-6-chloro-pregn-4,6-diene-17 alpla-ol-3,20 dione ) , cyproterone-17-acetate , and 6 alpha-bromo-17 beta-hydroxy-17 alpha-methyl-4-oxa-5 alpha-androstan-3-ine ( bomt ) were ineffective in competing for [ 3-h5d alpha dht binding sites , as were 4-androstene-3 , 17-dione , 17 beta-estradiol ( e2 ) , progesterone , and cortisol . the formation of the [ 3-h ] 5 alpha dht-tebg complex was extremely rapid ; the binding reaction was essentially completed in 15 s. the complex dissociated rapidly in the presence of charcoal . the dissociation rate constant ( kdiss ) was 0.157 min- minus 1 and the dissociation half-time t-1/2 ) was 4.5 min .
C0010621
cyproterone
C0056855
cyproterone