the bone loss was caused by : ( a ) a rapid surge in bone resorption , reflected in a significant increase in the number of osteoclasts per mm bone surface at 30 and 72 h and in the osteoclast surface at 72 h but not at later times , and ( b ) a sustained decrease in bone mineral apposition rate and bone formation rate ( osteoblast-referent ) throughout the 42-day immobilization period suggesting osteoblastic hypofunction ( reduced activity ) .
C0825429
bone surface
C0262950
bone