since it is known that inhibition of sulfation of n-hydroxy-2-acetylaminofluorene prevents the formation of covalently-bound 2-acetylaminofluorene adducts to proteins , rna , and dna in the rat liver ( meerman et al. , carcinogenesis , 2 , 413-416 , 1981 ) , the results from this study suggest that deacetylated , 2-aminofluorene adducts to dna are responsible for initiation of gamma-glutamyltranspeptidase positive foci in the rat liver ( because formation of these adducts is not affected by pentachlorophenol ) .
C0012854
dna
C0242958
adducts