in an effort to assess connective tissue biosynthetic activity in human liver disease , collagen proline hydroxylase ( a key enzyme in collagen biosynthesis ) and the uptake of ( 35 ) s sulphate ( a precursor of sulphated mucopolysaccharides ) were measured in hepatic tissue obtained mainly by percutaneous biopsy.a procedure is described for the quantitation of collagen proline hydroxylase in cryostat sections which allows for the simultaneous histopathological examination of the liver specimen .
C0023884
liver
C0736268
hepatic tissue