raf-1 tyrosine phosphorylation and kinase activity were increased by pdgf treatment of 3t3 cells or cho cells expressing wild-type pdgf receptors but not mutant receptors defective in transmitting mitogenic signals , suggesting that the increase in raf-1 kinase activity is a significant event in pdgf-induced mitogenesis .
C0032200
pdgf
C0018284
mitogenic