in the e. coli pyelonephritis , induced in female wistar rats by retrograde infection ( high pressure reflux ) , we investigated the influence of 1 ) the time of commencement of therapy , 2 ) the renal bacterial counts , i.e . the inflammatory activity of the pyelonephritis after endovesical instillation of cultures with different bacterial concentrations , and 3 ) the level of infection resistance of the experimental animal strain on the therapeutic response of the model infection with single doses of cefoxitin ( 150 mg/ml ) and cefotaxime ( 5 mg/ml ) .
C0022646
renal
C0034186
pyelonephritis