site-directed mutagenesis of h-2ld-chloramphenicol acetyltransferase fusion genes showed that mutations in the binding site , but not in other regions of the ics , abolish transcriptional activation of class i genes by ifn , providing evidence that specific binding of nuclear factors to the ics is an essential requirement for transcriptional induction .
C0162493
transcriptional
C0040649
transcriptional