examination of the model of the fixation site of the adenosine phosphate part of nad+ on horse liver alcohol dehydrogenase led us to synthesize a nad+ analogue n6- [ n- ( 8-amino-3,6-dioxaoctyl ) carbamoylmethyl ] -nad+ in order to alkylate the carboxylic acid group of asp-273 and to convert the normally dissociable coenzyme into a permanently bound prosthetic group .
C0001413
adenosine phosphate
C0027270
nad