ph-titrations with nadh show two ionizable groups in mitochondrial and cytoplasmic malate dehydrogenase , the first with a pka in the range 6.8-8.3 for the mitochondrial and 6.4-7.8 for the cytoplasmic enzyme , the second with a lower limit at 10.2 resp .
C0026237
mitochondrial
C0010834
cytoplasmic