when methotrexate was administered at either 96 or 24 h after asparaginase during the asparaginase-induced s-phase nadirs of l5178y/s+ and l5178y/s+/- cells , respectively , subsequent methotrexate polyglutamylation was inhibited 83 and 92 % compared to tumor cells exposed to methotrexate only .
C0080129
s-phase
C0007634
cells