the alkylations caused : ( i ) a decrease in the k ( cat ) values , particularly marked for the carboxymethylated b isoenzyme , ( ii ) a change in the apparent pk of the k ( cat ) curves , and ( iii ) a dependence of k ( m ) on ph , for the alkylated enzymes , in contrast to the ph-independent k ( m ) values of the native enzymes .
C0022173
isoenzyme
C0014442
enzymes