pulvomycin and the synonymous antibiotics labilomycin and 1063-z are shown to inhibit prokaryotic protein synthesis by acting on elongation factor tu ( ef-tu ) : in the presence of the antibiotic , the affinity of ef-tu for guanine nucleotides is altered , the ef-tu.gdp/gtp exchange is catalyzed , and the formation of the ef-tu.gtp complex is stimulated .
C0018328
guanine nucleotides
C0018353
gtp