an adaptation of the method of harper and brooker [ j. cyclic nucleotide res . 1,207 ( 1975 ) ] , its advantage lies in the fact that the simple acetylation of the samples -- a procedure developed by these workers -- greatly increases specificity and sensitivity beyond those of previous methods and permits the measurement of femtomole quantities of both cyclic nucleotides without prepurification .
C0028630
nucleotide
C0028631
cyclic nucleotides