thiorphan and acetorphan , two potent inhibitors of enkephalinase ( ec 3.4.24.11 membrane-metalloendopeptidase ) significantly reduced the castor oil-induced diarrhea in rats when administered intravenously ( or orally , for acetorphan ) but not when administered intracerebroventricularly .
C0007343
castor oil
C0011991
diarrhea