on the basis of these results , our previous studies on sfv entry , and the known effects of lipophilic amines on lysosomes , we conclude that the agents affect entry by a common mechanism : they prevent the transfer of the virus nucleocapsid into the cytoplasm by increasing the lysosomal ph above the critical value needed to trigger a low ph-dependent fusion reaction between the membranes of the lysosome and the virus .
C0024369
lysosomes
C0010834
cytoplasm