since the differentiation of this muscle cell line from myoblasts to nonfusing myocytes is accompanied by the development of high affinity insulin receptors and physiologic insulin-stimulated glucose and alpha-methylaminoisobutyric acid uptake , this continuously cultured system provides an excellent model for the study of differentiation and mechanism of insulin action in muscle , its quantitatively most significant target tissue .
C0596981
myocytes
C0026845
muscle