to elucidate the role of the central gamma-aminobutyric acid ( gaba ) system in the maintenance of deoxycorticosterone ( doca ) nacl hypertension , the responses of mean arterial pressure ( map ) , plasma norepinephrine ( ne ) , and epinephrine ( ep ) to intracerebroventricular ( icv ) administration of muscimol , a gaba agonist , and the responses of map to bicuculline , a gaba antagonist , and to clonidine , an alpha 2-adrenoceptor agonist known to lower blood pressure by inhibiting sympathetic tone , were examined in conscious , unrestrained 4 week doca/nacl hypertensive rats and age-matched uninephrectomized control rats .
C0020538
hypertension
C0009014
clonidine