we have shown that infusion of 10 mg amiodarone into the inflow circuit of ventilated and perfused rabbit lungs causes immediate increase in pulmonary artery pressure ( mean +/- sem ) ( from 13.6 +/- 1.2 to 40.6 +/- 9.5 mm hg , p less than 0.01 ) and pulmonary edema with marked increase in the pulmonary generation of thromboxane and leukotrienes c4 and/or d4 .
C0024109
lungs
C0034063
pulmonary edema