upon activation either by trypsin or by blood-clotting proteins involving clotting factors xii and high molecular weight kininogen , it undergoes proteolytic cleavage in which the mr = 80,000 chain reportedly is cleaved to a heavy and light chain of mr of about 48,000 and 33,000 , respectively .
C0015525
clotting factors xii
C0597304
proteolytic