three of the 4,5-disubstituted uracil nucleoside derivatives , 4-o- ( difluoromethyl ) -5-bromo-arau ( 5c ) , -5-methyl-arau ( 5e ) , and - ( e ) -5- ( 2-bromovinyl ) -arau ( 5g ) , displayed a high and selective inhibitory effect against hsv-1 , but only 5e was effective against both hsv-1 and hsv-2 comparably with the antiherpes potential of the reference compounds 9- [ ( 2-hydroxyethoxy ) methyl ] guanine ( acyclovir ) and 1-beta-d-arabino-furanosylthymine ( arat ) .
C0018321
guanine
C0001367
acyclovir