the effects of the oral hypoglycemic agents metformin and glibenclamide on receptor binding of insulin and insulin-induced receptor down-regulation were studied in cultured normal human fibroblasts , human breast tumors ( cell lines mcf-7 and t-47d ) and a human colon tumor ( cell line hct-8 ) in order to identify differences in receptor regulation between normal and transformed cells .
C0016030
fibroblasts
C0007634
cells