if , on the other hand , isolated hela cell nuclei were first incubated with labeled nad , the substrate for poly ( adp-ribose ) polymerase , prior to the preparation and fractionation of nuclease-digested chromatin , it was found that those chromatin fractions which possess significant poly ( adp-ribose ) polymerase activity ( nucleosome oligomers ) are relatively deficient in the labeled product of this enzyme , and that a considerable portion of the homopolymeric product is ultimately associated with the 11s v bodies .
C0007610
cell
C0008546
chromatin