light and electron microscopy revealed the features of type b synoviocytes prevalent in the cover layer in the early stage of the disease : polymorphism and rounding of the nuclei of synoviocytes , mitoses , fragmentation and degeneration of the nucleolus , loosening of the chromatin network and appearance of interchromatin granules , nuclear bodies , formation of multinucleated synoviocytes and symplasts , destruction of organelles , activation of lysosomal apparatus of the cells .
C0007610
nuclei
C0008546
chromatin