inhibition of dna synthesis as measured by [ 3h ] thymidine uptake into acid-insoluble material was used as an index of cannabinoid activity against isolated lewis lung cells , l1210 leukemia cells , and bone marrow cells incubated in vitro delta9- , delta8- , 1-hydroxy-3-n pentyl- , and 1-delta8-tetrahydrocannabinol , and cannabinol demonstrated a dose-dependent inhibition of dna synthesis whereas cannabidiol and 1-hydroxy-3-n-pentylcannabidiol were markedly less inhibitory in our in vitro cell systems .
C0006864
cannabinoid
C0039663
tetrahydrocannabinol