of 58 patients with paget 's disease treated with disodium ethane-1-hydroxy-1,1-diphosphonate ( ehdp ) in doses of 20 and 10 mg/kg/day , a group of 20 patients with the oligostotic form of the disease showed a significantly greater incidence of complications , such as worsening of bone pains , when compared with a group of 38 patients with the polyostotic disease ( p less than 0.05 ) .
C0012544
diphosphonate
C0086268
ehdp