this evidence , based on studies employing pharmacological , surgical , electrophysiological , and dietary manipulations of central nervous system serotonergic neurotransmission , suggests that increases in the activity of brain and spinal cord serotonin neurons are associated with analgesia and enhanced antinociceptive drug potency , whereas decreases in the activities of these neurons correlate with hyperalgesia and diminished analgesic drug potency .
C0027793
neurotransmission
C0027882
neurons