in in vitro studies , d-600 ( 10 ( -7 ) to 10 ( -3 ) m ) evoked a dose-related increase in the basal outflow of tritium from the rat isolated atria preloaded with [ 3h ] noradrenaline ( [ 3h ] na ) , indicating that depletion of cardiac noradrenaline stores by d-600 may be due to a direct action on sympathetic nerves rather than to increased reflex sympathetic activity secondary to profound vasodilation caused by the drug .
C0018792
atria
C0018787
cardiac