pathobiological endpoints used in these studies include alterations in incorporation rates of precursors into dna , rna and protein , in the clonal growth rate of cultured cells and in dna structure ( e.g . single-strand breaks , dna-protein crosslinks and chemical-dna adducts ) and the induction of differentiation , chromosomal and karyotypic abnormalities , mutations and neoplastic transformation .
C0012854
dna
C0242958
dna adducts