in the framework of frank-kamenetsky 's theory of melting of a polymer with stabilizing ligands the size of the binding site and binding constants ( k ) with the decrease of ionic strength , the lack of alterations in the dna uv absorption spectrum on complex formation and the data on the competitive binding of ethydium bromide suggest that at the first stage of the reaction an external complex is formed due to electrostatic interactions between quaternary nitrogen atoms of prospidine and dna phosphate groups .
C0598312
dna
C0012854
dna