like tamoxifen , ici 145680 demonstrated both estrogen-reversible ( at concentrations between 0.5-7.5 microm ) and estrogen-irreversible ( 10-20 microm ) inhibition of mcf 7 cell proliferation which was associated with a concentration-dependent accumulation of cells in the g0/g1 phase of the cell cycle .
C1156236
inhibition of
C0007634
cells