chronic secretory otitis and chronic tubal dysfunction , which are particularly frequent in childhood , may cause such changes in the tympanic membrane and/or middle ear , that conditions are created which later on , maybe years after remission of secretory otitis , may favour the development of cholesteatoma , non-cholesteatomatous chronic otitis and perforation of the tympanic membrane .
C0041445
tympanic membrane
C0013455
middle ear