twenty-one patients who were treated with chemotherapy combination ( m-2 protocol : melphalan , vincristine , bcnu , cyclophosphamide , prednisone ) plus plasma exchanges for three days at the start of each 5-week cycle survived longer ( median 17 months , p less than 0.01 ) than 16 patients who were treated with melphalan-prednisolone alone ( median 2 months ) .
C0065442
m-2 protocol
C0032952
prednisone