heme synthesis was measured by determining red cell ( 59 ) fe uptake and glycine-2- ( 14 ) c incorporation into red cell hemin in normal cf ( 1 ) female mice.2 ) both bovine and human hemin significantly decreased red cell ( 59 ) fe uptake 48 , 72 , and 96 hours after hemin injection.3 ) glycine-2- ( 14 ) c incorporation into red cell hemin was decreased to 50 % of control values after the administration of hemin ( 90 mumoles per kg ) .4 ) there was no significant difference between the plasma iron of mice injected with hemin and the values in control groups.5 ) protoporphyrin decreased the inhibitory effect of hemin on red cell ( 59 ) fe uptake by 64 % .6 ) there was no measurable effect of delta-aminolevulinic acid on hemin inhibition of red cell ( 59 ) fe uptake.7 ) data are presented to show that the effect of hemin is not by a dilution mechanism nor by a decrease in red cell maturation and subsequent release of reticulocytes into the peripheral blood .
C0032105
plasma
C0229664
peripheral blood