mutants dl312 , dl314 , hr1 , and hr3 with mutations in region e1a of adenovirus type 5 were defective for the induction of cell cycle abnormalities detectable by flow cytometry , cell dna replication , thymidine kinase production , and chromosome aberrations and did not synthesize the viral dna-binding protein ( e2a ) in rat cells .
C0007590
cell dna replication
C0007634
cells