the following results were obtained : ( 1 ) there was a time delay between administration of the toxicant and development of the testicular injury , ( 2 ) sertoli cell vacuolation in stages associated with the meiotic metaphase was the first histological sign of cellular injury at all doses , ( 3 ) subneurotoxic doses produced selective defects in germ cells in stages i-viii of the spermatogenic cycle , ( 4 ) both subneurotoxic and neurotoxic doses produced germ cell necrosis and generalized sloughing of germ cells , and ( 5 ) intensive intoxication followed by a 17-week recovery period resulted in an absence of all postspermatogonial germ cells from the seminiferous epithelium of three of five treated rats .
C0025564
metaphase
C0007634
cellular