using graded shear forces to dissociate effector-target cell conjugates , we found that ( a ) within an allosensitized lymphoid cell population derived from an heterogeneous mixed leukocyte culture , there were lymphocyte-target cell conjugates with binding strengths differing by a factor of at least 10 ( 2 ) , ( b ) even the minimal force required to release a significant amount of bound target cells could disrupt the plasma membranes of some tumor cells and ( c ) these tumor cells disrupted by shear forces were probably part of cytolysis-conducive rather than of non-cytolysis-conductive conjugates .
C0024264
lymphocyte
C0032131
plasma