the diagnosis was confirmed in 46 ( 15.6 % ) workers ( including 33 of 64 subjects with a history highly suggestive of occupational asthma in the previous seasons ) by ( 1 ) specific inhalation challenges in 33 subjects ( one immediate , nine dual , and 23 late asthmatic responses ) and/or ( 2 ) a combination of monitoring of peak expiratory flow rates ( n = 12 ) and significant changes in bronchial responsiveness to histamine ( n = 16 ) as well as in spirometry ( n = 18 ) after reappearance of symptoms on return to work .
C0264423
occupational asthma
C0004096
asthmatic