evidence for this pathway includes ( 1 ) the observation of deuterium isotope effects in metabolism and mutagenesis , ( 2 ) products ( aldehydes , alcohols , and n2 ) consistent with this pathway , ( 3 ) studies on metabolism of nitrosamines using purified cytochrome p-450 , ( 4 ) formation of dna adducts such as o6-alkylguanines which are consistent with those expected from the ultimate mutagen , ( 5 ) expected products and genotoxic effects of other sources of activated nitrosamines , e.g. , alpha-acetoxynitrosamines , alkanediazotates and related compounds .
C0025519
metabolism
C0010762
cytochrome