in invasive adenocarcinomas , ( a ) desmoplastic reaction was induced , ( b ) stromal fibroblasts proliferated significantly and were activated showing enlarged nuclei and abundant rough endoplasmic reticulum , and ( c ) some smooth muscle cells were endowed with well-developed rough endoplasmic reticulum in their axial cytoplasm , resulting in a similar appearance to `` '' myofibroblasts '' '' .
C0230779
rough
C0010834
cytoplasm