based on the observation that only [ ac-asn1 , phe-ome8 ] aii ( aii , angiotensin ii ) had significant activities ( 20 % oxytocic and 13 % pressor ) in the rat , with all other analogues having negligible agonistic and antagonistic effects , it is concluded that ionic interaction of the c-terminal carboxylate with the receptor is necessary for angiotensin binding and that hydrogen bonding has little effect .
C0003009
angiotensin ii
C0003018
angiotensin