adult t cell leukemia ( atl ) is a new disease entity with the following characteristic clinical and hematologic flutures : 1 ) acute or subacute t cell leukemia in adulthood 2 ) endemic in kyushu and southwest of shikoku 3 ) frequent skin infiltration 4 ) common hepatosplenomegaly and lymphadenopathy ( not so marked ) 5 ) mild or moderate bone marrow infiltration 6 ) hypercalcemia 7 ) typical leukemia cells with deeply-indented or lobulated nuclei and heterogeneous ( pleomorphic ) cells 8 ) no mediastinal mass 9 ) ineffective ordinary treatment and short survival time surface phenotypes of atl cells were okt 3 ( + ) 4 ( + ) 5 ( - ) 8 ( - ) tac ( + ) and leukemia cells suppressed pwm-induced ig synthesis in about half cases .
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nuclei
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cells