to determine whether changes in binding during pregnancy occur for common drugs or only for drugs that bind to a specific binding site , serum protein binding of three drugs -- diazepam ( site i ) , warfarin ( site iii ) , and salicylate -- and four fluorescent probes -- dansylsarcosine ( site i ) , 1-anilino-8-naphthalenesulfonate ( site i ) , 7-anilinocoumarin-4-acetic acid ( site ii ) , and 5-dimethylaminonaphthalene-1-sulfonamide ( dnsa ) ( site iii ) -- were determined in control and pregnant sera .
C0032961
pregnancy
C0012010
diazepam