these responses were not changed by indomethacin pretreatment and prostaglandin e ( 2 ) , but rebound contraction was sometimes augmented by the prostaglandin.5 two mechanisms for the effects of prostaglandin e ( 2 ) are suggested : a direct effect on smooth muscle , and an indirect action through the sympathetic nerves which by release of noradrenaline affect the acetylcholine release from parasympathetic nerve endings .
C0033554
prostaglandin
C0033559
prostaglandin