this , in conjunction with the demonstration that ptpase 1b abolished insulin stimulation of an s6 peptide ( rrlsslra ) kinase concomitant with a decrease in the phosphorylation of tyrosyl residues in a protein with the same apparent mr as the beta subunit of the insulin and insulinlike growth factor 1 receptors ( m. f. cicirelli , n. k. tonks , c. d. diltz , e. h. fischer , and e. g. krebs , submitted for publication ) , provides further support for an essential role of protein tyrosine phosphorylation in insulin action .
C0031727
kinase
C0031715
phosphorylation