oxygen free radicals and their metabolites generated from activated neutrophils have been implicated in mediating the cardiovascular dysfunction of such diverse etiologies as myocardial ischemia and reperfusion injury , gram negative sepsis , myocarditis and acute cardiac allograft rejection , but a direct demonstration of neutrophil derived oxygen free radical mediation of cardiovascular dysfunction has not been accomplished .
C0010054
myocardial ischemia
C0007226
cardiovascular