by contrast , srif ( 10 ( -7 ) -10 ( -10 ) -induced inhibition of grf ( 10 ( -8 ) m ) -mediated gh release was impaired in ap cells of diabetic rats compared to that in controls ( ic50 , 112 +/- 33 vs. 55 +/- 31 pm ; p less than 0.05 ) associated with a decrease in ap plasma membrane srif receptor concentration ( 63.4 +/- 15.6 vs. 160.3 +/- 13.7 fmol/mg protein ; p less than 0.05 ) , with no change in affinity .
C0037663
gh
C0032016
ap