in contrast , c-kit kinase defects conferred by the moderately dominant , homozygous viable alleles w41 or w55 or the homozygous lethal allele , w37 , were attributed to single-point mutations within the kinase domain of the c-kit polypeptide , which result in point substitutions of amino acid residues highly conserved in the family of protein tyrosine kinases .
C0031727
kinase
C0033681
family