in this study we have investigated heparin kinetics in patients with fulminant hepatic failure ( fhf ) after a single intravenous dose of heparin ( 2,500 units ) and found there was an increased clearance of heparin whether measured by its anti-xa effect ( t 1/2 = 27.8 +/- 2.9 min compared to t 1/2 = 50.2 +/- 2.7 min in normal controls p less than 0.001 ) or by the whole blood activated clotting time ( t 1/2 = 23.7 +/- 2.2 min compared to t 1/2 = 37.0 +/- 2.0 min p less than 0.001 ) .
C0019134
heparin
C0019139
anti-xa