the following characteristic features have occurred with sufficient frequency to suggest that the subsequent leukemia is a distinct clinicopathological entity : pancytopenia , megaloblastoid marrow , nucleated red blood cells in the peripheral blood , random chromosomal aberrations of the bone marrow in most patients ( 94 % ) , and refractoriness to antileukemia therapy ( response rate 6.5 % ) with a very short survival ( median one month ) .
C0030312
pancytopenia
C0005953
bone marrow