between 1974 and 1981 , 93 evaluable patients with stages iii ( nine patients ) and iv ( 84 patients ) disease who had received no prior therapy were placed on a combined regimen of 5-fluorouracil , 500 mg/m2 on days 1 and 8 , doxorubicin ( adriamycin ) , 50 mg/m2 , and cyclophosphamide , 500 mg/m2 on day 1 ( fac ) every 3 weeks for three cycles or until maximum tumor reduction occurred .
C0012634
disease
C0027651
tumor