it is the question of a radio-caused bone death that comes about by progressive and irreversible morphological alterations at bones and at vessels : loss of osteocytes , active osteoblasts and osteoclasts ( hypocellularity ) , injury of normal bone metabolism , slackening of regeneration process , extreme susceptibility to infections of the devitalized bone , radio-induced obliterating endarteritis with hyalinization , thrombosis and fibrosing of vessels , obliteration of the lumen and gradual reduction of blood-supply at the level of tissue ( hypovascularity and hypoxemia : aseptic osteoradionecrosis , radio-osteonecrosis ) .
C0262950
bone
C0029445
osteonecrosis