the long-term ( 12 months ) oral administration of the aromatic retinoid ro 10-1670 ( etretin ) to dogs in relatively high doses of 5.0 , 15.0 and 50.0/30.0 mg/kg/day was followed by acanthotic hyperplasia of the epidermis in the external auditory meatus and dose-dependent hypertrophy and/or hyperplasia of the canine ceruminous glands .
C0013444
external auditory meatus
C0229352
ceruminous glands