the cytotoxic effect of poly ( ri ) .poly ( rc ) for interferon-treated cells is preceded by discrete ultrastructural alterations in ( 1 ) the mitochondria : swelling of the cristae and increased density of their matrix , ( 2 ) the nucleus : disorganization of the structure , and ( 3 ) the endoplasmic reticulum : slight dilatation with disorganization and depletion of the filament bundles .
C0007634
cells
C0007610
nucleus