from the findings that the hypertensive effect of methoxamine and the hypotensive effect of clonidine were inhibited differently by various alpha-adrenoceptor antagonists and that the selectivity of these antagonists for the methoxamine and clonidine effect is similar , respectively , to that for alpha 1- and alpha 2-adrenoceptors in the peripheral tissues , we concluded that the methoxamine hypertension and the clonidine hypotension are due to the stimulation of alpha 1- and alpha 2- adrenoceptors in the brain , respectively .
C0020538
hypertension
C0009014
clonidine