danazol inhibits dose-dependently the mitochondrial 3 beta-hydroxysteroid dehydrogenase ( i50 = 3.1 microm ; ki = 1 microm ) ( noncompetitive inhibition ) and the cytoplasmic 20 alpha-hydroxysteroid dehydrogenase ( i50 = 1.4 microm ; ki = 2.6 microm ) ( competitive inhibition ) .
C0026237
mitochondrial
C0010834
cytoplasmic