others have shown that cpy ( 61 kd ) is synthesized as an inactive proenzyme ( 69 kd ) that is matured by cleavage of an 8 kd amino-terminal propeptide . sec mutants that are blocked in either of two early stages in the secretory process and accumulate endoplasmic reticulum or golgi bodies also accumulate precursor forms of cpy when cells are incubated at the nonpermissive temperature ( 37 degrees c ) .
C0014239
endoplasmic reticulum
C0007634
cells