diglycerides derived from the phospholipase c-mediated hydrolysis of phosphoinositides are implicated as important mediators of agonist-induced responses , including the stimulation of cell division . alpha-thrombin-stimulated proliferation of fibroblasts is associated with a sustained increase in cellular diglycerides , while the hydrolysis of phosphoinositides is transient ( wright , t. m. , rangan , l. a. , shin , h. s. , and raben , d. m. ( 1988 ) j. biol . chem . 263 , 9374-9380 ) .
C0016030
fibroblasts
C0007634
cellular