an excessive increase of p21 ( 5- to 10-fold over the control value ) occurred more frequently in tumors of t3 and t4 stages [ 15 of 25 ( 60 % ) ] than in tumors at t2 stage [ 6 of 29 ( 21 % ) ] , suggesting a correlation between advancement of disease and high p21 levels .
C0027651
tumors
C0012634
disease