to examine the mechanisms of the nephrotoxic synergy of bacterial cell wall lipopolysaccharide ( lps ) ( or endotoxin ) and the cephalosporin antibiotics , we have studied : 1 ) the effects on mean arterial blood pressure and the clearances of inulin , p-aminohippurate and cephaloridine ( cld ) of a 12 % -lethal dose of escherichia coli 0111-b4 lps ( 0.05 mg/kg b.wt.i.v . ) , with both low and high rates of saline infusion ( 0.1 ml/min vs. a 7.5-ml/kg load followed by 0.4 ml/min , respectively , in approximately 2-kg rabbits ) ;
C0023810
lipopolysaccharide
C0014264
endotoxin