in a reperfusion model in which anesthetized dogs were subjected to 3 hours of coronary artery occlusion followed by 3 hours of reperfusion , verapamil decreased infarct size when it was administered during the period of ischemia , but failed to decrease infarct size when administered only during the reperfusion phase , i.e. , after 3 hours of ischemia .
C0021308
infarct
C0022116
ischemia