in contrast , t-pa in a dose of 7500 u/kg/hr produced 35 +/- 6 % thrombolysis , but it did not produce a plasmin-mediated plasma proteolytic state or a significant increase in hemorrhage over the 4 hr of infusion . t-pa in a dose of 15,000 u/kg/hr produced 85 +/- 4 % thrombolysis but was associated with a plasmin-mediated proteolytic state and produced significant bleeding which , in contrast to streptokinase-induced bleeding , was delayed in onset .
C0038418
streptokinase
C0019080
bleeding