previous experiments with adp regio-specifically labeled with 17o in the phosphate groups had shown that mn ( ii ) was coordinated to the alpha and beta positions of adp in transition state analog complexes with creatine kinase that involved enzyme , mn ( ii ) , adp , creatine , and anions such as formate and thiocyanate ( reed , g. h. , and leyh , t. s. ( 1980 ) biochemistry 19 , 5472-5480 ) .
C0031603
phosphate
C0003075
anions