while ki-ras mrna levels remained relatively unchanged , mrnas for fos and sis increased significantly during the course of butyrate induced differentiation . c-fos induction can be detected 30 min after butyrate addition , a peak level ( greater than 20 fold ) was reached at 2 h , with a subsequent gradual decline . c-sis induction was detectable 24 h after butyrate exposure , at which time the cells have assumed morphological transition .
C1516343
differentiation
C0007634
cells