when plated on untreated chondrocyte multilayers or on multilayers which had been permitted to recover from budr treatment for 3 days , myogenic cells failed to form myotubes since extracellular matrix is present in untreated chondrocyte cultures and reappears in multilayers recovering from budr treatment , it is suggested that extracellular matrix is the active agent in the suppression of myogenesis an attempt was made to duplicate the suppressing activity of multilayer cultures by using ion exchange resins as substrates for myogenic cells myotubes formed on acidic and basic resin particles if extracellular matrix is the active suppressing agent , it may have to fulfill certain spatial distributional requirements before its activity is expressed
C0225369
chondrocyte
C0007634
cells