specific binding of [ 3h ] imipramine to its recognition sites in frontal cortex and levels of serotonin ( 5-ht ) , 5-hydroxyindoleacetic acid ( 5-hiaa ) and norepinephrine ( ne ) as well as uptake of serotonin by crude synaptosomal ( p2 ) fraction were determined in a group of rats chronically ( for 21 days ) treated with different types of antidepressant drugs : nortriptyline , fluoxetine , iprindole , phenelzine ( 10 mg/kg per day ) , maprotiline ( 20 mg/kg per day ) and vehicle only ( controls ) .
C0020934
imipramine
C0003289
antidepressant