the flurothyl-treated rats showed a greater locomotor activity response than rats that had not been convulsed.2 this enhanced response appears to be due to increased postsynaptic dopamine receptor sensitivity since flurothyl-treated rats also showed enhanced locomotor responses to methamphetamine ( 2 mg/kg ) and apomorphine ( 2 mg/kg ) .3 enhanced 5-hydroxytryptamine-induced activity responses following administration of tranylcypromine ( 20 mg/kg ) and l-tryptophan ( 50 mg/kg ) were also seen 24 h after the last of 10 daily flurothyl-induced convulsions.4 the increased 5-hydroxytryptamine response also appears to be due to increased postsynaptic sensitivity since the flurothyl-treated rats showed increased hyperactivity following administration of tranylcypromine ( 20 mg/kg ) and the suggested 5-hydroxytryptamine agonist , 5-methoxy n , n-dimethyltryptamine ( 2 mg/kg ) .5 no change in the brain concentration of 5-hydroxytryptamine , 5-hydroxyindoleacetic acid , tryptophan , dopamine or noradrenaline was observed 24 h after the last of 10 daily flurothyl-induced convulsions , compared to untreated rats .
C0006104
brain
C0086045
concentration