the effect of alpha interferon ( alpha ifn ) on colony forming unit , granulocyte-macrophage ( cfu-gm ) formation by normal bone marrow ( bm ) as compared with chronic granulocytic leukaemia ( cgl ) bm and peripheral blood ( pb ) was tested in semi-solid assay systems employing either 5637cm or recombinant granulocyte-macrophage colony stimulating factor ( gm-csf ) to support growth . alpha ifn ( greater than 125 u/ml ) caused consistent inhibition ( p = 0.02 ) of day-7 ( late progenitor ) colonies , but had little or no effect on either day-7 clusters or day-14 colonies/clusters .
C0023473
chronic granulocytic leukaemia
C0005953
bm