our results demonstrated that : ( 1 ) the frequency of precursor b cells producing each lupus autoantibody ( approximately 1 in every 100-400 lps-responding b cell ) was similar in two non-autoimmune ( c57bl/6 and balb/c ) and four sle-prone ( nzb , ( nzb x nzw ) f1 , mrl/mpj and bxsb/mpj ) mice despite the marked differences in autoimmune responses in the different sle-prone mice , and ( 2 ) the relative frequency of autoantibody-secreting precursor b cells was constant throughout life , and equally distributed among activated and resting b-cell populations and among b cells from the peritoneal cavity and spleen .
C0007634
cell
C1327616
secreting