the pathology of asthma is characterized by mucus plugging of the bronchi and bronchioles , shedding of the respiratory epithelium with the formation of creola bodies , denudation of the epithelium , the presence of necrotic eosinophilic material beneath the epithelium , a thickened basement membrane zone , bronchial smooth muscle hypertrophy , and goblet cell hyperplasia .
C0014609
epithelium
C0506994
goblet cell