this model allows simulation of experimental findings such as the glucose-induced accumulation of cyclic amp in islet cells , the calcium dependency of the latter accumulation , the time course of 45ca net uptake by the islets exposed to glucose and/or a phosphodiesterase inhibitor , the stimulation of insulin release by glucose , the suppression of such a release at low extracellular ca2+ concentration and its amplification by phosphodiesterase inhibitors , the restoration of a significant secretory response to glucose in islets deprived of ca2+ but exposed to a phosphodiesterase inhibitor , and the usual relationship between 45ca net uptake and insulin release .
C0022131
islet cells
C0021641
insulin