causes for increased red cell rigidity may be : spherocytosis ( familial hemolytic anemia ) , instable less fluid hb ( instable hemoglobinopathy ) , abnormal hbs-formation ( sickle cell disease ) , genetic synthesis defect of hb chains ( homozygous beta-thalassemia ) , enzyme defects ( autosomal recessive pyruvate-kinase deficiency ) .
C0019045
hemoglobinopathy
C0002895
sickle cell