the binding of [ ( 3 ) h ] -oestradiol-17beta was reduced if monohydroxytamoxifen or tamoxifen was administered 4 h before the oestradiol.4 tamoxifen ( 8 mug daily ) or monohydroxytamoxifen ( 1.28 mug daily ) did not prevent the translocation of [ ( 3 ) h ] -oestradiol ( 0.08 mug ) to the uterine cell nucleus on day 3 of a 3-day uterine weight test.5 the measurement of total nuclear oestrogen receptors by an exchange assay technique demonstrated a higher concentration of oestrogen receptors in anti-oestrogen-treated animals compared with controls.6 since the administration of anti-oestrogenic doses of non-steroidal anti-oestrogens during a 3-day uterine weight test did not inhibit the total binding of oestradiol in the uterus , or affect the translocation of the steroid to the nucleus , the mechanism of action of non-steroidal anti-oestrogens over the range of the partial agonist dose-response curve must involve an interaction , or competition of oestradiol-17beta- and anti-oestrogen-oestrogen receptor complexes for sites within the nucleus .
C0034804
oestrogen
C0007610
nucleus