tiropramide hydrochloride and some of its metabolites were studied in vivo for their antispasmodic activities on the following models : gastric emptying in the mouse retarded by cholecystokinin octapeptide ( cck-8 ) or morphine , progression of intestinal contents in the mouse , spontaneous motility of the colon in the anesthetized rabbit , diarrhea induced by castor oil in the rat , spasm of the sphincter of oddi provoked by morphine in the guinea pig , contractions of the urinary bladder in the anesthetized rat .
C0011991
diarrhea
C0007343
castor oil