pretreatment of rats with the cytotoxic agent 5-fluorouracil ( 150 mg/kg i.p . ) , which causes transient depletion of hemopoietic cells , on days -10 , -7 , -4 , -2 , and -1 prior to the administration of [ ring-3h ] -n-oh-aaf ( 10 mg/kg ) on day 0 resulted in different levels of n-oh-aaf binding to spleen and bone marrow dna without altering the pattern of dna adducts compared to that in control animals .
C0012854
dna
C0242958
dna adducts