in the neuroepithelium of these embryos we found that ( 1 ) the 0-1 m concentration had no detectable effect , ( 2 ) the 0-25 m concentration only affected mitosis which was blocked in metaphase so that mitotic figures accumulated near the neurocoele , ( 3 ) 0-31 m formamide totally inhibited interkinetic nuclear migration and affected only slightly the cell asymmetry , ( 4 ) the 0-37 m concentration considerably reduced the amount of cytoplasmic microtubules and that the cells became round , ( 5 ) at 0-43 m formamide , all microtubules had disappeared and all cells were spherical , ( 6 ) 0-5 m formamide all cells were spherical , detached from one another and the epithelium had lost its usual characteristics .
C0026255
mitosis
C0007634
cells