the purpose of this study was to determine firstly whether the isolated enzyme dna polymerase alpha , which functions within the dna replicase system , exhibits different sensitivity against the thiol-blocking agent 4-hydroxy-nonenal ( hne ) when adult rat liver and the rapidly dividing yoshida ascites hepatoma were used as enzyme sources and , secondly , whether the reaction catalysed by dna polymerase is the most sensitive step of the dna replicase system of native cells .
C0012888
dna polymerase alpha
C0012892
dna