in rats with unilateral renal artery stenosis and an intact contralateral kidney , a malignant course of hypertension ( mh ) may develop , which is characterized by 1 ) high bp levels , 2 ) sodium and water loss and a polyuric-polydipsic syndrome , 3 ) marked activation of the renin-angiotensin system , 4 ) malignant nephrosclerosis in the contralateral kidney and high plasma urea concentrations , and 5 ) deterioration of the animals ' general condition .
C0035067
renal artery stenosis
C0022646
kidney