it is suggested that 1 ) among euthyroid relatives with a family history of graves ' disease , there are many with abnormalities in trh responsiveness and t3 suppressibility , 2 ) nonsuppressible subjects are more likely to be trh hyporesponders and vice versa , 3 ) hyperthyroidism or hypothyroidism occurs frequently in euthyroid relatives with a family history of graves ' disease , and 4 ) thyrotoxicosis occurs frequently in trh-hyporesponders , and hypothyroidism occurs in the others .
C0020550
hyperthyroidism
C0040156
thyrotoxicosis