the acute administration of cyclic antidepressant drugs ( 2.5 mg/kg , i.v . ) resulted in different mydriatic effects ( amitriptyline greater than protriptyline approximately imipramine greater than clomipramine greater than nortriptyline greater than desipramine approximately maprotiline ) which were attenuated ( 17-55 % ) by idazoxan ( 1 mg/kg , i.v. , 5 min ) and reserpine ( 5 mg/kg , s.c. , 18 h ) indicating that , besides the well-known anticholinergic properties of some of these drugs , their mydriatic effects are due in part to activation of alpha 2-adrenoceptors ( through endogenous noradrenaline ) .
C0002600
amitriptyline
C0028420
nortriptyline