twelve patients ( 57 % ) who developed , within the first 2 years of treatment , histological effects of fluoride ( f ) ( increased bone formation surfaces together with thickened osteoid seams or hyperosteoidosis ) increased their cabi significantly ( p less than 0.01 ) over the 4 year period , from 0.64 +/- 0.02 to 0.78 +/- 0.03 ( or 21.0 +/- 2.9 % ) .
C0682561
osteoid
C0262950
cabi