the possibility that nuclear localization of immunoglobulins occurred artifactually in the 6 patients was considered and was discounted by determining antinuclear antibody titers on serum obtained concurrently with the renal biopsy nuclear localization was not confined to areas of histologically evident parenchymal destruction , indicating that antinuclear antibodies do not react only with nuclear antigens after tissue breakdown , but may gain access to intracellular antigens prior to cell dissolution .
C0069115
nuclear antigens
C0003320
antigens