randomized studies in which alpha-msh , acetaminophen or ibuprofen , or a combination of alpha-msh and antipyretic drug , were given iv to rabbits made febrile by endogenous pyrogen , indicate that the antipyretic effect of the peptide is summative with those of the drugs . alpha-msh has been shown to have a wide safety margin in earlier research and the results suggest that combinations of peptide and antipyretic drugs might be safer and have fewer side effects than larger quantities of the drugs alone .
C0020740
ibuprofen
C0015967
febrile