these changes in the coagulo-fibrinolytic factors in the acute stage of ttp suggest that fibrinogenolysis might be induced by t-pa , released through vascular reaction at an uninvolved area of vascular lesions caused by platelet agglutinates , which would then release large amounts of pai-1 inhibiting t-pa and u-pa activities at the occlusive lesion .
C0034155
ttp
C0005847
vascular