the response of aml cells to these growth factors is extremely heterogeneous , and the tilting of the balance between self-reproduction ( leading to perpetuation of the leukaemic process ) and differentiation ( 'death ' of the malignant cells ) depends on several parameters , on the type and combination of factors to which the cells are exposed , with il-3 and gm-csf tending to favour self-renewal , and g-csf and m-csf tending to favour differentiation .
C0023467
aml
C0334227
malignant cells