murine mammary carcinoma fm3a cells , deficient in cytosol thymidine ( dthd ) kinase ( tk ) activity and transformed by the herpes simplex virus type 1 ( hsv-1 ) or type 2 ( hsv-2 ) tk gene ( designated fm3a tk-/hsv-1 tk+ and fm3a tk-/hsv-2 tk+ , respectively ) proved extremely sensitive to the cytostatic action of the potent antiherpetic drugs ( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) and ( e ) -5- ( 2-iodovinyl ) -2'-deoxyuridine ( ivdu ) .
C0007634
cells
C1383501
cytosol