we have utilized an in vivo drug metabolism technique ( i.e . injecting the chemical into rat and isolating plasma with metabolites from blood ) for detecting the genotoxicity of indirectly acting cyclophosphamide and its directly acting metabolite phosphoramide mustard in cultures of human peripheral blood lymphocytes of normal individuals , fanconi 's anaemia ( fa ) and aplastic anaemia ( aa ) patients , wild-type chinese hamster ovary cells ( cho ) and its dna repair-deficient mutant 43-3b cells .
C0015625
fanconi 's anaemia
C0002874
aplastic