the effects of synthetic alpha-human atrial natriuretic polypeptide ( alpha-hanp ) on cortisol secretion by adrenocortical adenoma cells from patients with cushing 's syndrome ( cs cells ) in primary monolayer cultures , compared to cultured normal adrenal cells , were studied . alpha-hanp significantly inhibited cortisol secretion by human normal adrenal cells in culture , but had no direct effect on cortisol secretion from cs cells , in the presence or absence of 10 ( -8 ) m acth .
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