it is concluded that , in addition to its requirement for fatty acid oxidation , coenzyme a exerts two independent effects on mitochondrial metabolism as here determined in vitro : ( a ) under conditions mimicking those in the intact cell with respect to phosphorylation-dependent respiration ( adp limiting ) , acyl-coa formed from added coenzyme a and fatty acid inhibits the adenine nucleotide translocase , resulting in a lowering in the extramitochondrial atp/adp ratio obtained at any given rate of phosphorylation-limited respiration , and ( b ) under state 3 conditions ( adp in excess ) coenzyme a ( less than 50 -- 200 micrometer ) specifically suppresses oxidation of long-chain fatty acids by limiting the rate of formation of intramitochondrial acyl-coa .
C0001374
acyl-coa
C0009226
coenzyme a