dynorphin- ( 1-13 ) ( dyn- ( 1-13 ) ) and various analogs substituted in positions 8 and 10 were synthesized by the solid-phase technique and analyzed for their ability to inhibit the electrically evoked contraction of the guinea pig ileum ( gpi ) and to compete with the binding of [ 3h ] -ethylketocyclazocine ( ekc , kappa ligand ) , [ 3h ] - [ d-ala2 , mephe4-gly-ol5 ] -enkephalin ( dago , mu ligand ) and [ 3h ] - [ d-ser2 , thr6 ] -leu-enkephalin ( dslet , delta ligand ) to membrane preparations of the guinea pig cerebellum or rat brain .
C0014298
enkephalin
C0014294
leu-enkephalin