simvastatin , a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase , was compared with cholestyramine resin in a randomized open-label 12-week multicenter study of 251 high-risk patients with familial or nonfamilial hypercholesterolemia .
C0074554
simvastatin
C0020443
hypercholesterolemia