hydrocortisone ( 10 ( -5 ) m ) and adrenalin ( 10 ( -4 ) m ) , added to an incubation medium , were shown to produce a labilizing effect on lysosomal membranes , increasing free activity of acid phosphatase and cathepsin d and osmotic sensitivity of lysosomes . alpha-adrenergic blocker dihydroergotamine ( 3.4 x 10 ( -5 ) m ) blocked an increase in free activity of acid phosphatase as a result of adrenalin action but did not eliminate hydrocortisone labilizing action . beta-adrenergic blocker propranolol ( 3 x 10 ( -4 ) m ) lowered free activity indices and osmotic sensitivity of lysosomes to control values both in the presence of adrenalin and hydrocortisone .
C0230812
lysosomal membranes
C0024369
lysosomes