chan , cancer res. , 43 : 1511-1517 , 1983 ) on lower nucleotide uptake rates in these tumor mitochondria , we propose that the lower atp efflux and higher adp efflux rates may cause a futile cycle of adp transport across the mitochondrial membrane which may contribute to high rates of aerobic glycolysis ( by stimulating key glycolytic enzymes such as hexokinase and phosphofructokinase ) observed in these fast and intermediately growing tumors .
C0026237
mitochondria
C0596952
mitochondrial membrane