to determine whether hyperinsulinaemia can cause insulin resistance in man and , if so , whether this occurs at a receptor or post-receptor site , nine normal volunteers were infused with insulin for 6 h at a rate ( 2 mu x kg-1 x min-1 ) which resulted in steady-state plasma insulin concentrations of 140 +/- 13 mu/l and four subjects were infused with saline ( 0.45 % ) .
C0020459
hyperinsulinaemia
C0021655
insulin resistance