experiments in which nuclei from control and drug-treated cells were supplemented with cytoplasmic fractions from either control or drug-treated cells , or with exogenous dna , demonstrate that ledakrin and other 1-nitro-9-aminoacridines inhibit dna replication in hela s3 cells by interfering with the dna template , while not affecting dna polymerase ( s ) or other enzymes and replication factors .
C0010834
cytoplasmic
C0007634
cells