whereas low mr urokinase is derived from mature mr 54,000 scu-pa by limited hydrolysis by plasmin first of the lys-158-ile-159 peptide bond and then of the lys-136-lys-137 , scu-pa-32k is generated by specific hydrolysis of the glu-143-leu-144 peptide bond by an unidentified protease . scu-pa-32k resembles its mr 54,000 scu-pa counterpart by its very low activity on chromogenic substrates for urokinase , by plasminogen-dependent fibrinolytic activity on fibrin plates , and by the lack of specific binding to fibrin .
C0020291
hydrolysis
C0032140
plasminogen