we have investigated the effect on the human pituitary-gonadal axis of the h2-receptor antagonists cimetidine 300 mg and ranitidine 50 , 100 , and 200 mg by i.v . bolus , or treatment for 6 months with either cimetidine ( 1000 mg/day for 1.5 months followed by 400 mg/day for 4.5 months ) or ranitidine ( 200-400 mg/day for 1.5 months followed by 100-200 mg/day for 4.5 months ) .
C2757005
h2-receptor antagonists
C0008783
cimetidine