hexamethonium inhibited dmpp , but affected neither sns per se nor the facilitatory effects of mcn-a-343 and ahr 602 on sns.4 mcn-a-343 , cocaine and desipramine ( but not ahr 602 or hexamethonium ) blocked the net cardiac noradrenaline uptake and increased the positive chronotropic effect of noradrenaline.5 prior perfusion with concentrations of cocaine and desipramine sufficient to block uptake reduced or abolished the facilitatory effects of both mcn-a-343 and ahr 602 on sns.6 cocaine , mcn-a-343 and ahr 602 displayed local anaesthetic properties on the guinea-pig wheal and frog nerve plexus tests , and their relative potencies in this respect were similar to those for inhibition of dmpp-evoked transmitter overflow .
C1372804
positive chronotropic
C0028351
noradrenaline