intraperitoneal administration of leupeptin to rats induced a hemoglobin-hydrolyzing protease which was most active at ph 3.5 and was insensitive to pepstatin in various tissues such as the liver , kidney , and muscle , as observed previously in adult rat hepatocytes in primary culture ( tanaka , k. , ikegaki , n. , and ichihara , a . ( 1979 ) biochem . biophys . res . commun . 91 , 102-107 ) .
C0736268
tissues
C0227525
hepatocytes