1 the stimulatory effects of neurotensin ( nt ) and several nt fragments were evaluated in two pharmacological preparations : rat stomach strips and isolated spontaneously beating atria of guinea-pigs.2 in rat stomach strips , nt elicited a dose-dependent contractile effect in concentrations varying between 1.3 x 10 ( -9 ) and 5.4 x 10 ( -7 ) m.3 the contractile effect of nt ( 1.3 and 5.4 x 10 ( -8 ) m ) in this tissue was not modified by atropine ( 3.4 x 10 ( -7 ) m ) , methysergide ( 2.0 x 10 ( -6 ) m ) , a mixture of cimetidine ( 8.0 x 10 ( -6 ) m ) and diphenhydramine ( 7.8 x 10 ( -6 ) m ) , indomethacin ( 1.4 x 10 ( -5 ) m ) , 8-leu-angiotensin ii ( 1.0 x 10 ( -6 ) m ) , glucagon ( 2.0 x 10 ( -6 ) m ) or somatostatin ( 3.0 x 10 ( -7 ) m ) .4 rat stomach strips desensitized by bradykinin ( 6.1 x 10 ( -6 ) m ) or substance p ( 7.4 x 10 ( -6 ) m ) maintained their sensitivities to nt ( 1.3 and 5.4 x 10 ( -8 ) m ) .5 in guinea-pig atria , nt produced a dose-dependent positive inotropic action in concentrations varying between 5.4 x 10 ( -10 ) and 2.7 x 10 ( -7 ) m.6 the inotropic effect of nt ( 2.7 x 10 ( -9 ) m ) was not influenced by methysergide ( 2.8 x 10 ( -6 ) m ) , atropine ( 3.4 x 10 ( -7 ) m ) , practolol ( 1.5 x 10 ( -5 ) m ) , 8-leu-angiotensin ii ( 1.0 x 10 ( -6 ) m ) , or indomethacin ( 1.4 x 10 ( -5 ) m ) , but it was reduced by 37 % by cimetidine ( 4.0 x 10 ( -5 ) and 2.0 x 10 ( -4 ) m ) .
C0026820
contractile
C0006100
bradykinin