the following observations further confirmed the specific involvement of the cytochrome p-450 lm3c isozyme : ( i ) only anti-cytochrome p-450 lm3c isozyme antibodies intensively inhibited midazolam metabolism , ( ii ) incubation of microsomes , prepared from tao-treated rabbits , with midazolam in the presence of potassium ferricyanide which restored the functional cytochrome p-450 lm3c isozyme , increased midazolam metabolism to a similar extent , and ( iii ) in the presence of cyclosporin a , a specific substrate of the rabbit cytochrome p-450 lm3c isozyme , midazolam metabolism was inhibited in a concentration-dependent manner .
C0010762
cytochrome p-450
C0025519
metabolism