these findings suggest that pth-rp and il-1 alpha produced by the tumor cells were synergistically responsible for the humoral hypercalcemia observed in both the original patient and the tumor-bearing nude mice , and that at least two bone-resorbing factors [ pth-rp and another nonadenylate cyclase-stimulating bone-resorbing factor ( s ) ] are active in patients with malignancy-associated hypercalcemia , in whom nephrogenous camp excretion is neither increased nor decreased .
C0020437
hypercalcemia
C0149911
malignancy-associated hypercalcemia