the distribution of the asbestos in the p388d1 cells was similar to that seen previously in cultured peritoneal macrophages , and it was concluded that the cytotoxic effect of asbestos towards the cells was due to mechanical effects , e.g. , by penetrating structures such as the nucleus or phagosomes , by preventing the ordered movement of organelles with the cell or by disrupting the cytoskeletal framework of the cell .
C0007634
the
C0010853
cytoskeletal