the relationship between the oral dosage and plasma concentration of the long-acting cardioselective beta-adrenoceptor blocker atenolol and the antihypertensive response to the the degree of beta-adrenoceptor blockade and change in plasma renin activity ( pra ) was evaluated in patients with mild-to-moderate essential hypertension in a double-blind , randomized , between-patient , dose-ranging ( 25 , 50 or 100 mg once daily for 4 weeks ) study .
C0034783
adrenoceptor
C0001643
beta-adrenoceptor