studies using the catechol-o-methyltransferase inhibitor , u-0521 , and the o-methyl derivative of epi , metanephrine , suggested that catechol-o-methyltransferase present in gc dramatically reduces the potency of epi , but is not involved in the synergism between epi and 2-oh-e2 .
C0025562
metanephrine
C0014563
epi