the plasma concentrations of nabumetone and its active metabolite , after administration of 1,000 mg single dose p.o. , are followed at 0 , 0.5 , 1 , 2 , 4 , 6 , 8 , 12 , 24 , 30 and 48 h in 6 patients with laboratory evidence for functional liver insufficiency caused by liver cirrhosis , confirmed by biopsy .
C0023884
liver
C0023890
liver cirrhosis