the following conclusions and speculations can be tentatively drawn from the changes in lipoprotein composition and metabolism : ( 1 ) the presence of apo b-48 in serum vldl and the high serum apo a-iv concentrations indicate a greater than normal contribution of alimentary remnant particles to the hypertriglyceridemia of uremic patients , ( 2 ) the presence of apo e and c in triglyceride-enriched serum ldl , together with the triglyceride enrichment of all lipoproteins , probably stems from a deficiency of lipoprotein lipase ( lpl ) and hepatic lipase ( hl ) activity , ( 3 ) the decreased ratio of serum apo c-ii/c-iii in vldl is at least in part responsible for the depressed activity of lpl , ( 4 ) the accumulation of lipoprotein particles with distorted apoprotein and lipid patterns ( particularly beta-vldl with enrichment in cholesterol ) could be associated with an increased atherogenesis because a recent study has demonstrated a strong association between raised serum idl and vldl concentrations and the degree of coronary atherosclerosis , ( 5 ) the increased apo e content of vldl and hdl in uremic patients could particularly point to a disturbed cholesterol metabolism because such lipoproteins could interact with ldl at apo b , e receptors , ( 6 ) the decrease in serum hdl-cholesterol has been shown to be strongly associated with atheromatous vascular disease , and this could also hold for uremic patients ;
C0023779
lipid
C0023820
lipoproteins