these findings suggest that ( 1 ) defective bone growth in congenital rubella is a direct effect of viral infection of bone , ( 2 ) a disorder of mucopolysaccharide syntheses may contribute to the osseous lesions that occur in this disease , and ( 3 ) organ cultures of human embryonic and fetal rat bones may serve as convenient models for studying the pathogenesis of this virus-induced congenital osteopathy .
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