analogs of growth hormone-releasing factor- ( 1-29 ) -nh2 ( grf-29 ) involving derivatization with alkyl substituents at the n-terminus , with or without concomitant alkylation of basic amino acids within the peptide chain ( lysine in positions 12 and 21 ) , were synthesized using solid-phase methodology and tested for their ability to stimulate growth hormone release in pentobarbital and urethane-anesthetized rats and in 4-day primary cultures of rat anterior pituitary cells .
C0301714
basic amino acids
C0024337
lysine