the following evidence shows the effect of ub-aldehyde on protein breakdown to be indirectly caused by its interference with the recycling of ub , leading to exhaustion of the supply of free ub : ub-aldehyde markedly increased the accumulation of ub-protein conjugates coincident with a much decreased rate of conjugate breakdown . release of ub from isolated ub-protein conjugates in the absence of atp ( and therefore not coupled to protein degradation ) is markedly inhibited by ub-aldehyde .
C1623036
protein breakdown
C0041538
ub