to do so , the ddn analogues need first to be phosphorylated by cellular kinases to the corresponding 5'-triphosphates ( ddntps ) , and together with the affinity of the ddntps for the hiv reverse transcriptase ( relative to their affinity for the cellular dna polymerases ) , the extent by which the ddns are phosphorylated to the ddntps are critical determinants of their potency and selectivity as anti-hiv agents .
C0031727
kinases
C0012892
dna polymerases