in order to clarify role of lpr gene of mrl/mp-lpr/lpr ( mrl/l ) mice in the development of immunological abnormalities and lupus nephritis , f2 mice were obtained from crosses of ( mrl/1 x akr ) f1 mice and examined with regard to lymph node enlargement , numbers of immunoglobulin ( igm and igg ) producing cells ( pc ) in the spleen , serum levels of anti-trinitrophenyl ( tnp ) and anti-dna antibodies , amounts of circulating immune complexes ( ic ) and histopathological findings of the kidney .
C0024143
lupus nephritis
C0022646
kidney