our previous work [ proc . natl , acad . sci . usa ( 1977 ) 74 , 1463-1467 , 3326-3329 ] is consistent with the view that ( a ) the hemin-controlled inhibitor of protein synthesis in reticulocyte lysates ( active eif-2 kinase ) is formed by phosphorylation of proinhibitor ( inactive eif-2 kinase ) catalyzed by cyclic amp-dependent protein kinase ( atp-protein phosphotransferase ; ec 2.7.1.37 ) , and ( b ) hemin prevents this conversion by blocking the interaction of cyclic amp with the kinase 's regulation subunit , thereby rendering the enzyme inactive .
C0031715
phosphorylation
C0031727
kinase 's