we found that b cells committed to the production of anti-insulin igg , but not igm , autoantibodies are present at much higher frequency in the circulation of newly diagnosed iddm patients before insulin treatment ( 0.209 +/- 0.142 % , mean value +/- sd of total igg-producing cell precursors ) as compared with age-matched healthy controls ( 0.032 +/- 0.030 % of total igg-producing cell precursors ) .
C0021641
insulin
C0011854
iddm