to further delineate the hypothalamic mechanism ( s ) responsible for hf , the basal levels and pulsatile release of lh , fsh , estradiol , and estrone and the rate of occurrence of hfs ( measured objectively ) were evaluated in patients with a defect of gnrh secretion [ isolated gonadotropin deficiency ( igd ) ] , patients with abnormalities of afferent input to gnrh neurons [ hypothalamic amenorrhea ( ha ) ] , and postmenopausal women with severe hfs .
C0020663
hypothalamic
C0023610
gnrh