these revealed perisinusoidal fibrosis , bile canalicular alterations and hepatocellular alterations including the appearance of fat droplets , proliferation of the smooth endoplasmic reticulum , accumulation of lipofuscin-like pigment , foci of cytoplasmic degeneration , proliferation of microbodies and prominent mitochondrial changes .
C0010834
cytoplasmic
C1519020
proliferation