to elucidate the mechanism of vacuolation frequently encountered in the normal epidermal cells surrounding skin tumors , 0.5 and 1.0 % procaine hydrochloride , and 1.0 % lidocaine hydrochloride with and without epinephrine were injected either i.d . or s.c. into mature white male rabbits , and the sites of injection were biopsied either immediately or after 15 min . the epidermis of the site of intradermal injection showed a significant increase in the number of vacuolated cells in contrast to the site of s.c. injection ( p less than 0.001 ) irrespective of the kinds of local anesthetics and the time lapse from injection to biopsy .
C3496194
epidermal cells
C0014520
epidermis