five nuclear morphologic criteria of malignancy used by cytopathologists were prominent in the tumorigenic lines : altered chromatin pattern characterized by increasing size of chromatin granules and chromatin clumping , sharp angularity of large nucleolar and/or chromocenter borders with spicule formation ( pointed projection ) , irregular parachromatin clearing ( increase in the clarity of the clear spaces between chromatin threads , granules and clumps ) , uneven thickness of chromatin at the nuclear border , and variability in nuclear size and shape from cell to cell .
C0008546
chromatin
C0007634
cell