tricyclic compounds in which the nitrogen in the middle ring was substituted with a carbon atom ( amitryptyline and chlorprothixene ) are most effective in causing cell death and in decreasing proline transport and delta ph ( ic50 congruent to 5 microm ) , whereas depletion of cellular atp requires a higher drug concentration ( ic50 = 12 microm ) .
C0007587
cell death
C0007634
cellular