twenty-five samples of fresh malignant cells of patients with acute leukemia ( 16 with acute myeloblastic leukemia , five with acute lymphoblastic leukemia , and four with chronic myelocytic leukemia in blast crisis ) and of two patients with colon carcinoma were exposed for 1 hr to different concentrations of methotrexate ( mtx ) or trimetrexate ( tmq ) .
C0334227
malignant cells
C0005699
blast crisis