the following morphological and histochemical changes have been observed : increased acidophilia and fuchsinophilia in the single and grouped muscle fibres , foci of infiltrations by mononuclear cells , contraction bands , and outlines of myocardial fibres , separation of myofibrils , granular disintegration of cardiomyocytes , healed infarcts , depletion and excessive accumulation of glycogen in muscle fibres , presence of neutral fats , cholesterol and its esters in atheromatous plaques of coronary arteries , presence of neutral fats in some cardiomyocytes : focal acid phosphates , loss of activity of mg- and ca-dependent atpases and sdh : oedema of mitochondria with disorganization of cristae , disorganisation of fibres and lysis of myofilaments , margination of chromatin in cardiomyocyte nuclei , increased number of lysosomes , intensified symptoms of egzocytosis , widening of channels of sarcoplasmatic reticulum , oedema of endothelium of capillary vessels and increased number of the collagenous fibres in the interstitial space .
C0027061
myocardial
C0225828
cardiomyocyte