based on the methods developed in our laboratory to quantify benzodiazepine intoxication and withdrawal , trs were designed to evaluate midazolam 's capacity to induce dependence in the rat after definable acute ( 120 mg/kg p.o . ) , sub-acute ( 120 mg/kg q.i.d . x 3 days ) and chronic ( 120-180 mg/kg bid . x 5 weeks ) dosing that was near maximally tolerable .
C0005064
benzodiazepine
C0026056
midazolam 's