in accordance with the results of classical experiments performed in vitro with calf thymus chromatin and the fish protamine salmine , we have observed that this highly basic , small molecular weight protamine can not cause major displacement of histones from nucleosomal core particles at concentrations several times higher than physiological ( arginine/nucleotide ratios 1-8 ) and that hyperacetylation of histones facilitates nucleosome disassembly .
C0036107
salmine
C0033603
protamine