since mz heterozygotes are almost always , and ms phenotypes sometimes , associated with decreased serum alpha 1-at levels , and since z and mz phenotypes are associated with increased hepatic fibrosis or cirrhosis , these variants may be relevant to problems of spontaneous fibrosis or methotrexate-induced hepatotoxicity in psoriasis . alpha 1-at deficiency may also contribute to guttate flares with infection and to increased o-2 . production by psoriatic sera-stimulated polymorphonuclear leukocytes ( pmns ) .
C0025677
methotrexate
C0033860
psoriasis