3 ) potent classical dihydrofolate reductase inhibitors were identified that were either not substrates for mouse liver folylpolyglutamate synthetase ( e.g. , 4-amino-4-deoxy-n10-methylpteroyl-l-alpha-aminoadipate ) or were much better substrates than methotrexate for this enzyme ( e.g. , aminopterin ) ;
C0025677
methotrexate
C0002583
aminopterin