a combination of two intercalating agents , mitoxantrone and daunorubicin with vincristine ( the don regimen ) was studied in 16 patients with refractory acute leukemia , including three patients with myeloblastic transformation of refractory anemia with excess of myeloblasts after the failure of first-line chemotherapy and one additional patient with aml relapsing while off therapy .
C0026259
mitoxantrone
C0023467
aml