seven daily intramuscular ( im ) injections of cortisone acetate ( 25 mg/kg b.w . ) given to rats or rabbits produced , ( i ) a pronounced reduction in the numbers of small lymphocytes in thymus-independent areas , ( ii ) atrophy of the thymic cortex , ( iii ) atrophy of germinal centres and ( iv ) a consequent depressed production of germinal centre-derived cells .
C0040113
thymus
C0229948
thymic