in high risk patients ( extremity tumors greater than 100 ml tumor volume , central tumors ) , cyclophosphamide in conventional dose ( 1200 mg/m2/course ) was replaced by high doses of ifosfamide ( 6 g/m2/course ) with mesna uroprotection ( vaia ) .
C0010583
cyclophosphamide
C0020823
ifosfamide