in order to discriminate among potential etiologies , we asked whether the expression of the mottled mutation causes abnormalities in the metabolism of trace metals other than copper in hemizygous mottled ( blotchy ) cultured skin fibroblasts , and whether we can differentiate mutant and normal cells according to their response to metal inducers of metallothionein .
C0016030
fibroblasts
C0007634
normal