covalent binding of ( atomic ) sulfur released in the cytochrome p-450 monooxygenase catalyzed metabolism of certain thiono-sulfur compounds appears to be responsible for the inhibition of monooxygenase activity and the loss of cytochrome p-450 seen on administration of these thiono-sulfur compounds in vivo or incubation with cytochrome p-450 monooxygenase enzymes in vitro .
C0025519
metabolism
C0010762
cytochrome p-450