the aim of this study is firstly to attempt to form an explanation of the enzymatic effects of aminoglycosides by studying the excretion of a , b , i isoenzymes and by calculating the ratio a/b + i during gentamicin , tobramycin and amikacin therapy and secondly , by using this method , to try to propose a marker for evaluating nephrotoxicity .
C0002556
aminoglycosides
C0002499
amikacin