because decerebration did not alter the depression due to clonidine , and intraventricular ( but not intrathecal ) administration of oxymetazoline mimicked the effect of clonidine , the depressant effects of alpha 2-adrenergic agonists are mediated through alpha 2-adrenergic receptors localized in the brainstem .
C0009014
clonidine
C1373110
alpha 2-adrenergic agonists