calculation of the molar-free energy changes accompanying monomer and immune complex binding revealed not only that the intrinsic binding activity of mononer was sufficient to account for the complex binding activities by simple cooperation of linked antibodies , but also that the cross-linking of antibodies with antigen imposed a strain on the antibody-receptor interaction , resulting in complex binding energies that were lower than the values expected from a simple cooperative mechanism .
C0003313
immune complex
C0003241
antibodies