it therefore seems that the requirements for activation of suppression by cd4+ dy+ t-cell clones in this in vitro model bear many similarities to those for cd4+ helper t cells , namely , mediation by mhc class ii with cd4 involvement , dependency on lfa-1-influenced cell interactions , and reliance on clonal expansion caused by il-2 and possibly amplified by il-1 and/or il-6 .
C0039215
cd4
C0019630
mhc class ii