it may be concluded that ( 1 ) glucose autoregulates its own production or utilization by modulating the glycogen and glycolytic pathways , ( 2 ) autoregulation is lost in severe diabetes leading to fasting hyperglycemia , and ( 3 ) insulin has a permissive effect on the autoregulation of glucose balance by maintaining the rate-limiting enzymes , glycogen synthase and glucokinase , so that glucose can exert its effect on these pathways .
C0020456
hyperglycemia
C0021641
insulin