when a marked stimulation of the reninangiotensin system induced in the rat by bilateral adrenalectomy and salt-depletion is abruptly blocked by a 48-hr substitution treatment which desoxycorticosterone acetate ( doca ) and saltload , one observes : 1 ) an absolute increase of a form of renin revealed only after prior acidification ( ph , 2.5 ) of kidney extract before usual incubation at the optimum ph of 6.5 and 2 ) the simultaneous appearance of many granules containing crystalline cores in the epithelioid cells of the juxtaglomerular apparatus .
C0022646
kidney
C0022445
juxtaglomerular apparatus