preoperative chemotherapy was conducted in seven cases of osteosarcoma by twice administering intraarterial infusions of cisplatin ( 100 mg/m2/day ) and the effects were studied through evaluations of clinical symptoms , plane radiograms , angiographic findings , serum alkaline phosphatase levels determined prior to and after the intraarterial infusion , and the rate of necrosis of tumor cells in the resected material .
C0029463
osteosarcoma
C0008838
cisplatin