here we demonstrate that proximal beta-globin dna sequences lying greater than 112 base pairs ( bp ) 5 ' to the cap site are not involved in determining the erythroid-specific induction characteristics of this gene in transient expression assays , whereas an enhancer sequence within a 300-bp pvuii fragment lying approximately 400 nucleotides 3 ' to the polyadenylation signal is intimately involved in determining the erythroid cell specificity and correct time of induction of beta-globin transcription during red cell maturation .
C0949765
polyadenylation
C0040649
transcription