the higher level ( 120 micrograms/ml ) of nitrofurazone in a perfusion medium lacking the glutathione ( gsh ) precursors , glycine , glutamic acid and cysteine , caused a marked increase in bile flow ( from 1.01 +/- 0.07 to 2.33 +/- 1.07 microliters/min/g ) , massive biliary efflux of glutathione disulfide ( gssg ) ( from 0.55 +/- 0.07 to 60.6 +/- 25.4 nmol/min/g ) and a sharp decline in the caval efflux of gsh ( to undetectable levels ) and the tissue level of gsh ( from 5.74 +/- 0.20 to 2.68 +/- 0.13 mumol/g ) .
C0061516
gssg
C0017817
gsh