these and other data on increased levels of histamine and hdc during mitogen-induced lymphocyte blastogenesis , as well as experiments revealing immunomodulatory effects of histamine and histamine agonists and antagonists on lymphocyte blastogenesis , are consistent with the hypothesis that following infection with gram-negative bacteria , the histamine-induced increase in glucocorticoid secretion results in inhibition of hdc in splenocytes , a concomitant attenuation of histamine production , and a resulting return to immune homeostasis .
C0019605
hdc
C1512468
histamine production