the hepatic intrinsic clearances for enalapril ( 26.1 ml/min ) and enalaprilat ( 0.7 ml/min ) , found in a previous study , were used for simulation because , along with their given diffusional clearances ( 75 and 2 ml/min , respectively ) , they yielded a high extraction ratio for drug ( e = 0.86 ) and a poor extraction ratio for the preformed metabolite ( e = 0.05 ) .
C0014025
enalapril
C0014027
enalaprilat