activation effect of trapidil on pgi2 generation in the rat aorta ( kawamura et al , 1980 ) and rabbit heart ( our data ) , and its inhibitory effect both on the biosynthesis and thromboxan a2 action ( ohnishi et al , 1981 ) suggest that antiaggregation and coronarolytic actions , positive inotropic and chronotropic effects of trapidil on the myocardium are mediated via local generation of pgi2 and thromboxan a2 .
C0018787
heart
C0027061
myocardium