the accumulation of f-2,6-p2 caused by chlorpropamide ( 1 mm ) was parallel to the stimulation of l-lactate production ( 36.6 +/- 4.8 versus 26.1 +/- 2.6 mumol of lactate/g of cells x 20 min ; n = 5 , p less than 0.05 ) and to the inhibition of gluconeogenesis ( 0.57 +/- 0.1 versus 0.94 +/- 0.09 mumol of [ u-14c ] pyruvate converted to glucose/g of cells x 20 min ; n = 5 , p less than 0.05 ) .
C1512207
inhibition of
C0017725
glucose