in 18 patients ( 16 men , two women , mean age 58 years ) with coronary artery disease and angina of effort , the results of low ( 40 mg every 6 hours ) and high-dose ( 80 mg every 6 hours ) propranolol therapy were compared to those of low ( 80 mg every 6 hours ) and high-dose ( 120 mg every 6 hours ) verapamil therapy in a double-blind , randomized , placebo-controlled evaluation which lasted eight weeks : two weeks of placebo therapy , two weeks of propranolol or verapamil ( one week low-dose , one week high-dose ) therapy , three days of down-titration followed by one week of placebo therapy , two weeks of propranolol or verapamil therapy ( whichever was not given earlier in the trial ) ( one week low-dose , one week hgh-dose ) and three days of down-titration .
C0002962
angina of effort
C0033497
propranolol