biological evaluation of the 5-methyl-5-deaza analogues together with previously reported 5-deazaaminopterin and 5-deazamethotrexate for inhibition of dihydrofolate reductase ( dhfr ) isolated from l1210 cells and for their effect on cell growth inhibition , transport characteristics , and net accumulation of polyglutamate forms in l1210 cells revealed the analogues to have essentially the same properties as the appropriate parent compound , aminopterin or methotrexate ( mtx ) , except that 20 and 21 were approximately 10 times more growth inhibitory than mtx .
C0002583
aminopterin
C0025677
mtx