experimental manipulations of the interspace microflora in volunteers , monitored with quantitative cultures , demonstrated that symptomatic , macerated , hyperkeratotic process results from an overgrowth of resident organisms if the stratum corneum barrier is damaged by preexisting fungi , while overgrowth of the same organisms in normal , fungus-free interspaces does not produce lesions .
C0029235
organisms
C0016832
fungus