a spatial separation of the generator ( endothelial cells ) from the effector ( vascular smooth muscle ) has allowed to prove that edrf is nitric oxide , that its activity is inhibited by superoxide anions and by chemicals which act via free radicals , finally , that the release of edrf and prostacyclin is coupled by a receptor-mediated activation of phospholipase c .
C0016693
free radicals
C0028128
edrf