as holoprosencephaly without chromosome defect may be associated with other cns-related anomalies such as mental retardation , mental illness , facial paralysis , endocrine disorders , deafness , spina bifida , and myelomeningocele , we present a family in which one girl had a myelomeningocele , a brother had orbital hypotelorism , facial and cerebral asymmetries , cerebral palsy , abducens paralysis , and inner ear deafness .
C0080178
spina bifida
C0025312
myelomeningocele