the typical hemodynamic effects of sotalol in normotensive humans , even with depressed myocardial function , are a reduction in heart rate with little or no change in blood pressure , a reduction in cardiac output with no change in stroke volume , and little or no change in pulmonary wedge pressure and left ventricular end-diastolic pressure or volume , and little or no change in ejection fraction either at rest or during exercise .
C0037707
sotalol
C0428977
reduction