in rats , a large number of sarcomas , including fibrosarcomas , hemangiosarcomas , and osteosarcomas in both males and females and malignant hemangiopericytomas in females , occurred in the spleen and other abdominal organs at incidences that were dose related in each sex ( p < 0.001 ) and that in direct comparisons were significantly higher ( p < 0.001 ) in the high-dose groups of each sex than in the corresponding control groups ( males : controls , 0/20 , low-dose 6/49 , high-dose 31/49 ;
C1261473
sarcomas
C0016057
fibrosarcomas