these data support earlier evidence ( matthews , r.g. , wilkinson , k.d. , ballou , d , p. , and williams , c.h. , jr. ( 1976 ) in flavins and flavoproteins ( singer , t.p. , ed ) pp . 464-472 ; elsevier scientific publishing co. , amsterdam ) that the role of nad+ in the nadh-lipoamide reductase reaction catalyzed by lipoamide dehydrogenase is to prevent accumulation of inactive 4-electron reduced enzyme by simple reversal of the reduction of 2-electron reduced enzyme by nadh .
C0016223
flavoproteins
C0023783
lipoamide dehydrogenase