when heart rate and systemic arterial blood pressure of the donor dog were decreased dose-dependently by i.v . administration of alinidine ( 10-300 micrograms/kg ) , decreases in atrial rate and atrial developed tension of the isolated preparation were induced in a dose-dependent manner , confirming that i.v . administration of alinidine directly induced negative chronotropic and inotropic effects in situ dog heart .
C0018792
atrial
C0018787
heart