the following evidence from our research has implicated the macrophage as an important effector cell in pyran and/or c. parvum induced host resistance to solid tumors : ( 1 ) increased infiltration of tumors with histiocytes following systemic treatment with pyran ; 17 ( 2 ) activated peritoneal macrophages with tumoricidal activity have been recovered from the peritoneal cavity of normal or tumor bearing mice treated with pyran or c. parvum ; 17 ( 3 ) activated peritoneal macrophages mixed with tumor cells in vitro and transplanted into syngeneic recipients inhibited tumor growth ;
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