we used ha-ras-transformed madin-darby canine kidney ( mdck ) cells as a model to study possible signal transduction mechanisms underlying the induction of glucagon responsiveness by the differentiation inducers prostaglandin e2 ( pge2 ) and 8-bromo-cyclic ( 8-br-camp ) amp and the inhibition of induction by phorbol ester or a serum factor .
C0034678
ras
C0037083
signal transduction