furthermore marked porphyrin accumulation was not seen with many drugs that induce delta-aminolevulinate synthase and cytochrome p-450 but was more characteristic of compounds that reduced the metabolism of protoporphyrin to heme , such as 1,4-dihydro-3,5-dicarbethoxycollidine ( ddc ) and high doese of hydralazine .
C0010762
cytochrome p-450
C0025519
metabolism