in an attempt to develop an objective , quantitative test to assess the reactogenicity of candidates for attenuated influenza virus vaccines , the clinical responses and bronchial reactivity to methacholine were assessed in 36 normal volunteers lacking antibody to both hemagglutinin and neuraminidase ( doubly seronegative ) who were inoculated with either wild-type or temperature-sensitive attenuated influenza a ( h1n1 ) virus by intranasal droplets .
C0021403
influenza virus vaccines
C0021400
influenza