treatment of the cells with 1 x 10 ( -8 ) mol/l phorbol 12-myristate 13-acetate ( pma ) leads to the induction of multi-nucleation and hyperploidy in the cells , with approximately 35 % of the cells exhibiting two or more nuclei per cell , and greater than 80 % of the cells enlarging in size .
C0007610
nuclei
C0007634
cells