the ability of hepatocytes to activate 2-acetylaminofluorene to reactive intermediates capable of binding to dna and inhibiting new dna synthesis decreased as a function of time in culture . gamma-glutamyl-transferase-positive hepatocytes from diethylnitrosamine-treated rats were observed to be relatively insensitive to carcinogen inhibition of dna synthesis .
C0012854
dna
C0598312
dna synthesis