daily intraperitoneal injection of cadmium chloride ( 1 milligram per kilogram ) for 45 days enhanced gluconeogenesis as evidenced by significant increases in the activities of liver and kidney cortex pyruvate carboxylase , phosphopyruvate carboxylase , hexosediphosphatase , and glucose-6-phosphatase , the quartet of key , rate-limiting enzymes involved in the biotransformation of noncarbohydrate precursors into glucose .
C0017715
gluconeogenesis
C0017725
glucose