to clarify the electrophysiological mechanisms of the antiarrhythmic effects of mexiletine , we examined the actions of mexiletine ( 0.1 -- 30 mg/l ) on action potential characteristics ( phase 0 amplitude , overshoot , maximum upstroke velocity , maximum diastolic and activation voltages , duration at 50 % and 90 % repolarization ) of cardiac purkinje fibers using standard microelectrode techniques .
C0003195
antiarrhythmic
C0025887
mexiletine