in dogs treated 3 times daily with diazepam , 2 mg kg-1 orally , for 2 weeks , severe abstinence symptoms were precipitated in all animals by infusion of either antagonist but differences were found in the type of the symptoms : ro 15-1788 induced rigid postures or rigid walking with increased muscle tone , tremor , twitches and jerks , whereas zk 93426 did not alter motility but induced generalized myoclonic jerks and tonic-clonic seizures .
C0026837
rigid
C0026826
increased muscle tone