the mean plasma half-life ( t1/2 ) of antipyrine was prolonged ( 21.69 +/- 1.92 hr ) in a group of 10 patients with hereditary hepatic porphyria , 8 of whom had acute intermittent porphyria ( aip ) confirmed by decreased erythrocyte uroporphyrinogen-1-synthetase ( uro-s ) activities and 2 of whom had mixed hepatic porphyria , in comparison to the mean of 20 normal control subjects ( 12.65 +/- 0.86 hr , p less than 0.01 ) .
C0162533
hepatic porphyria
C0162565
acute