when concentrations of uterine cytoplasmic receptor were selectively depleted by translocation of 90-95 % of the cytoplasmic oestrogen receptor to the nucleus , saturation analysis studies revealed that the antioestrogens , tamoxifen and ci 628 , were bound to high-affinity , saturable binding sites which were present at about 2.5 times the concentration of the residual oestrogen receptor sites .
C0007610
nucleus
C0034804
oestrogen receptor