1 the effects of pentobarbitone ( pb ) and other sedative/hypnotic drugs have been examined in relation to gamma-aminobutyric acid ( gaba ) in vitro on the superfused isolated superior cervical ganglion of the rat and in vivo on single units in the brain stem of the anaesthetized rat.2 pb , and other barbiturates , depolarized the ganglion in a dose-dependent manner ( threshold concentration 100-300 mum , cf . gaba depolarization threshold 1 mum ) .
C0030883
pb
C0004745
barbiturates