in contrast , inhibition of growth , apparent cell death , and unusual morphological changes were observed in both normal and transformed cells when high concentrations of either pge1 ( 10 micron ) or the phosphodiesterase inhibitor 1-methyl , 3-isobutylxanthine ( 0.5 mm to 2 mm ) were used , which was indicative of toxic effects of the drugs .
C0007587
cell death
C0007634
cells