studies of ca2+ fluxes in cell organelles showed that mitochondria isolated from cf fibroblasts accumulate 2-3 times more ca2+ than controls [ 79.5 +/- 8.2 versus 33.7 +/- 4.7 nmols x mg mitochondrial protein-1 x 10 min-1 ( +/- sd ) ] , ca2+ accumulation in mitochondrial reliably distinguished between cf and control or heterozygote cells ( p less than 0.0005 , n = 11 ) .
C0026237
mitochondrial
C0007634
cells