these results suggest that ( - ) -amphetamine has a higher apparent volume of distribution ( vd ) than ( + ) -amphetamine [ vd for ( + ) - and ( - ) -amphetamine , 2.5 mg/kg i.v . = 3.35 and 4.61 liters/kg , respectively ; vd for ( + ) - and ( - ) -amphetamine 10 mg/kg i.v . = 2.36 and 4.61 liters/kg , respectively ] and that the ( - ) -isomer may be extracted more efficiently by the liver [ plasma clearance ( v ) for ( + ) - and ( - ) -amphetamine 2.5 mg/kg i.v . = 6.91 and 9.09 liters/hr/kg respectively ; v for ( + ) - and ( - ) -amphetamine 10 mg/kg i.v . = 2.85 and 4.33 liters/hr/kg , respectively ] resulting in lower plasma and brain concentrations after i.p . administration .
C0006104
brain
C0086045
concentrations