the results of this study could suggest the following : 1 ) isoproterenol-induced myocardial cell damage is similar to ca overload , 2 ) pretreatment with diltiazem could reduce the deleterious effects of isoproterenol-induced myocardial cell damage , but it could not prevent the effects of ca overload completely , and 3 ) posttreatment with diltiazem could not provide any beneficial effect either on the isoproterenol-induced or on the ca-overloaded myocardial cell damage , and 4 ) the beneficial effects of diltiazem are probably derived from the enhanced buffering function of mitochondria to cytosolic ca or from selective inhibition of transsarcolemmal ca influx .
C0027061
myocardial
C0225828
myocardial cell