these results indicate that these hepatocarcinogens bring about an increase in putrescine and in the spermidine/spermine ratio in the liver not only by enhancement of ornithine decarboxylase but also by induction of the spermidine n1-acetyltransferase activity which is the rate-limiting step in the acetylase-oxidase pathway for interconversion of the polyamines .
C0034170
putrescine
C0037871
ratio