these data suggest ( i ) that sv40 large t antigen induces or activates a protein kinase , one substrate of which is p53 , ( ii ) that transformation-defective mutants are impaired in kinase induction , and ( iii ) that either a certain phosphorylation state of p53 or the sv40-induced kinase is critical for efficient transformation .
C0031715
phosphorylation
C0031727
kinase