for each enzyme , stimulation of the reaction rates was found to be chiefly due to a dramatic enhancement by monovalent cations of the rate constant ( k2 ) for acylation of the enzyme since the dissociation constant ( ks ) for enzyme-substrate interactions was increased in the presence of cations , and the deacylation rate constant ( k3 ) was not affected by these activators .
C0007449
monovalent cations
C0007447
cations