habekacin -- 30 mg/kg seven days -- induced a decrease of cortical enzymatic activities , an increase of the number of lysosomes , a great accumulation of myeloid bodies , an alteration of lysosomal membranes habekacin -- 50 mg/kg seven days and 150 mg/kg -- induced a decrease of creatinine clearance and ultrastructural alterations of renal tubular cells .
C0024369
lysosomes
C0230812
of lysosomal membranes