the dnase i ( ec 3.1.21.1 ) sensitivities of the simian virus 40 ( sv40 ) genome , the pbr322 genome , and the herpes simplex virus type 1 thymidine kinase ( hsv-1 tk ) gene have been compared in teratocarcinoma-derived stem ( 12-1 ) and differentiated ( 12-1a ) cell lines established by transfection of thymidine kinase ( atp : thymidine 5'-phosphotransferase , ec 2.7.1.21 ) -deficient f9 cells with dna from a tripartite plasmid genome consisting of the pbr322 genome , the sv40 genome , and the hsv-1 tk gene .
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differentiated
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cells