treatment of c57bl/6j mice with three successive doses of all-trans retinoic acid ( 28 mg kg-1 body weight ) on 8 day , 6 h ( 8d,6h ) , 8d,12h , and 8d,18h of gestation resulted in a high incidence ( 79 % , 31/39 fetuses ) of spina bifida with myeloschisis ( spina bifida aperta ) in near term fetuses .
C0080178
spina bifida
C0037917
spina bifida aperta