moreover , the guinea pigs which had once been inoculated with the blood of yellow fever patients without succumbing to the infection , notwithstanding the fact that they had shown a definite febrile reaction after 4 to 5 days , were found to be refractory to a subsequent inoculation of a culture of leptospira icteroides all these observations pointed to the possible relation of this organism to the disease known as yellow fever in guayaquil .
C0009450
infection
C0012634
disease