loss of intercellular junctions ( desmosomes ) , alterations in the chemical composition and physical properties of the cell surface coat ( loss of fibronectin and heparan sulfate ; excessive amounts of hyaluronate ) , and loosening of cell-substrate interactions ( loss of hemidesmosomes , fibronectin , and heparan sulfate ) , are among the most frequently listed causes of tumor cell shedding .
C0021721
intercellular junctions
C0699040
of