these data are compatible with suppression being mediated by anti-antigen antibody , either ( a ) via blockade of different srbc epitopes recognized by a limited set of b cell clones in each mouse strain , ( b ) via triggering of an anti-idiotypic response , either antibody or suppressor t cell in nature , restricted to activity in cultures containing b cells sharing vh structures with the original antibody , or ( c ) via interference by preformed antibody with t cell help directed at idiotype bearing b cells .
C0003316
epitopes
C0021013
idiotype