having no first pass effect on the liver , parenteral administrations have less influence than oral ones on the synthesis of certain proteins by the liver ( increased shbg , cbg , tbg , transferrin , ceruloplasmin , angiotensinogen , clotting factors vii , ix , x and x complex ; decreased antithrombin iii and anti xa ) and on lipid metabolism ( increased biliary cholesterol , triglycerides and hdl , especially hdl2 ; reduced ldl ) .
C0023884
liver
C0015502
clotting factors vii