ym-08054-1 was the most potent among all of the tested antidepressants in the inhibition of reserpine-induced facilitation of convulsions as well as in the potentiation of reserpine-induced facilitation of convulsions as well as in the potentiation of 5-hydroxytryptophan ( 5-htp ) -induced syndromes in mice , though the inhibitory effect of this agent on reserpine-induced hypothermia was weaker than that of either amitriptyline or desipramine , suggesting relatively selective effects of ym-08054-1 upon 5-ht rather than ne uptake in vivo .
C0003289
antidepressants
C0002600
amitriptyline