we confirmed that precursor and mature forms of both il-1 alpha and il-1 beta can be detected in the culture supernatants after stimulation of the macrophages with 10 to 20 micrograms lps/ml but , in addition , we report the novel finding that il-1 beta is exclusively secreted in its unprocessed precursor form after stimulation of the cells with either 0.5 to 1 microgram lps/ml or with l. monocytogenes .
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secreted
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