using the sv40-transformed human keratinocyte line , svk14 , which exhibits characteristics of simple , nonkeratinizing epithelia , we have shown that igf i stimulation of these cells results in extensive multilayering , increased cell size , accumulation of involucrin , modulation of keratin 18 and expression of keratins 14 and 10 , whilst t-antigen expression is maintained in the multilayered cells .
C0022567
line
C0007634
cells