pulsed field agarose gel ( pfg ) electrophoresis , originally used to improve the resolution by length of linear dna [ cantor et al . ( 1988 ) annu . rev . biophys . biophys . chem . 17 , 287-304 ] , is found here to cause atypical sieving of 48.5-97.0-kb open circular dna .
C0012854
dna
C0012925
circular dna