excretion of 2,3-dinor-6-keto-prostaglandin f1 alpha , a major urinary prostacyclin metabolite , was significantly higher in 9 patients with severe atherosclerosis and evidence of platelet activation ( 251 to 1859 pg per milligram of creatinine ) than in 54 healthy volunteers ( 45 to 219 pg per milligram of creatinine ; p less than 0.001 ) .
C0033567
prostacyclin
C0003850
atherosclerosis