however , this effect was probably mediated by an increase in the generation of endogenous prostaglandin , as it was accompanied by an increase in the luminal release of prostaglandin e2 and indomethacin prevented both the stimulation of alkaline secretion and luminal prostaglandin e2 release by leukotriene c4 .
C0033554
prostaglandin
C0012472
prostaglandin e2