this 'exhaustion ' is caused by inhibition of cyclo-oxygenase , since these rings still convert cyclic endoperoxides but not arachidonic acid into prostacyclin , and most probably is due to high concentrations of peroxides : it can be accelerated by h2o2 or by interrupting the glutathione cycle , while it is delayed by reduced glutathione .
C0031180
peroxides
C0020281
h2o2