the possibility of utilizing mouse teratocarcinoma stem cells as intermediaries for production of new strains of mice with preselected mutant or foreign genes requires that , after propagation in culture ( to allow for genetic manipulation and selection ) , the cells be capable of normalization and orderly development in carrier embryos and , ultimately , of germ-cell formation .
C0206664
teratocarcinoma
C0017471
germ-cell