the clinical association of an increased incidence of acute myelogenous leukemia ( aml ) with previous chemoradiotherapy , the detection of specific karyotypic changes in these secondary ( therapy-induced ) cases of aml and the discovery of increasing levels of oncogene-specific rna in leukemia cells suggest that one potential site of action of environmental agents might be the proto-oncogenes in human hematopoietic stem cells .
C0023467
aml
C1517806
leukemia cells