since this pattern of calcification also resembles that seen in cns folate deficiency caused by both congenital folate deficiency and that which is methotrexate-induced , we propose that intracranial calcification in dhpr deficiency is caused by inadequate cns tetrahydrofolate and may be prevented by the use of folinic acid .
C0016412
folate deficiency
C0023413
folinic acid