advances leading to recognition of the relation of the renin-angiotensin system to aldosterone include : ( 1 ) development of analytic techniques for measuring aldosterone , ( 2 ) discovery of an aldosterone-stimulating factor in circulating plasma , ( 3 ) the finding that a potent aldosterone-stimulating factor is secreted by the kidney , ( 4 ) evidence that synthetic angiotensin ii increases aldosterone secretion , ( 5 ) fractionation of crude kidney extracts and the finding that aldosterone-stimulating factor is renin , ( 6 ) the observation that high plasma renin activity occurs in secondary aldosteronism , and ( 7 ) recognition that the renin-angiotensin-aldosterone system occurs in congestive heart failure and in renovascular and malignant hypertension .
C0022646
kidney
C0268790
renovascular