the oral administration of nifedipine 5 mg rapidly decreased bp from 163 +/- 22/101 +/- 10 to 127 +/- 12/82 +/- 9 mmhg ( mean +/- sd ; p less than 0.001 ) , and increased heart rate from 72 +/- 8 to 76 +/- 6 beats/min ( p less than 0.05 ) , plasma renin activity rose from 1.2 +/- 0.6 to 1.4 +/- 0.8 ng/ml/h ( p less than 0.05 ) , and plasma nifedipine concentration was 75.6 +/- 22.0 ng/ml 30 min after administration ( n = 7 ) .
C0020649
decreased bp
C0028066
nifedipine