there was no significant correlation of the changes in cardiac variables from pretreatment values with total serum concentrations , but the free concentration of disopyramide in plasma correlated better with cardiac effect , and the relationships of the free concentration of disopyramide to the changes in lvfp and in svr from pretreatment values were significant ( p less than 0.05 ) .
C0018787
cardiac
C0225897
lvfp