acute administration of the steroid did not significantly modify the brain content of these tryptophan metabolites while , when repeatedly administered at doses of 5 or 50 mg/kg i.p. , hydrocortisone significantly reduced the cortical content of quin ( by 28 % , p less than 0.05 and 21 % , p less than 0.05 respectively ) and the utilization of 5-ht ( as evaluated from the ratio 5-hiaa/5-ht by 22 % , p less than 0.05 at 50 mg/kg ) .
C0006104
brain
C0423896
content