besides possessing negative chronotropic and inotropic effects which were demonstrated by decreased heart rate ( hr ) , cardiac index ( ci ) and double product ( dp ) of the heart , propranolol significantly increased systemic vascular resistance ( svr , 12 % , p less than 0.05 ) and the time constant of left ventricular ( lv ) isovolumic pressure fall ( t , 10 % , p less than 0.01 ) .
C1372752
negative chronotropic
C0033497
propranolol