although the therapeutic emphasis in tricyclic antidepressant overdose has been on reversing the anticholinergic effects with physostigmine , there is considerable evidence suggesting that the life-threatening manifestations of tricyclic antidepressant overdose -- the conduction defects , bradyarrhythmias , heart block , etc -- are much more like quinidine and are more appropriately treated with phenytoin , or other drugs which enhance intracardiac conduction and myocardial contractility .
C0018794
heart block
C0034414
quinidine