reported are 1-year follow-up results of a randomized clinical trial comparing three strategies of managing clinically significant patent ductus arteriosus at the time of diagnosis in premature infants : ( 1 ) immediate administration of a three-dose course of intravenously administered indomethacin in addition to usual medical therapy ( fluid restriction and use of diuretics or digitalis or both ) , with surgery as a backup measure , ( 2 ) usual medical therapy alone initially , with indomethacin as the first and surgery as the final backup measure , and ( 3 ) usual medical therapy alone initially , with surgery alone as backup .
C0013274
patent ductus arteriosus
C0021246
indomethacin