taking into consideration ( a ) that the aminoglycosides antagonize the presence of ca++ and ( b ) that mechanisms of ototoxicity involve ionic alterations in endolymph , we suggest that : aminoglycoside ototoxicity could be the result of the reaction between aminoglycosides and anionic polyelectrolytes , of the group of polysulfated polysaccharides , in a metachromatic process .
C0022023
ionic
C0003075
anionic