in previous studies in this laboratory , highly purified liver microsomal cytochrome p-450 was shown to catalyze the hydroperoxide-dependent hydroxylation of a variety of substrates in the absence of nadph , nadph-cytochrome p-450 reductase , and molecular oxygen , and evidence was obtained that the oxygen atom in the product was derived from the peroxide .
C0020281
hydroperoxide
C0031180
peroxide