using pulse-labeling of 5-bromo-2'-deoxyuridine ( brdu ) , a thymidine analogue incorporated into the nuclei of dna-synthesizing ( s-phase ) cells , the antiproliferative effect of csa was revealed as a decrease in the number of brdu-positive human ek grafted onto nude mice receiving a daily subcutaneous injection of 50 mg/kg of csa .
C0007610
nuclei
C0080129
s-phase