as an in vitro model system for such changes in cell morphology , we have used cell cultures of the rat bladder carcinoma-derived cell line nbt-ii which , on exposure to inducing medium containing a commercial serum substitute ( ultroser g ) , show an extensive change in their organization ( epithelial-mesenchymal transition ) : the junctions between the epithelial cells are split , the epithelial cell organization is lost , and the resulting individual cells become motile and assume a spindle-like fibroblastoid appearance .
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junctions
C0007634
cells