analysis of chromosome breakage with mitomycin c ( mmc ) and folate-deficient culture conditions was undertaken on 18 prader-labhart-willi syndrome ( plws ) patients ( 10 with 15q12 deletion [ 5 females , 5 males ; mean age = 17.9 yr , range of 0.3 to 40 yr ] and 8 without deletion [ 2 females , 6 males ; mean age = 18.6 yr , range of 7 to 26 yr ] ) , 21 plws parents with an average age of 39.2 yr and a range of 25 to 70 yr ( 12 fathers [ 8 fathers of plws children with the 15q12 deletion and 4 fathers of plws children with normal chromosomes ] and 9 mothers [ 4 mothers of plws children with the 15q12 deletion and 5 mothers of plws children with normal chromosomes ] ) , and age-matched control individuals .
C0008059
children
C0027361
individuals