in a series of investigations of rat myocardial , rat lung , and human lymphocyte alpha- and beta-adrenergic function with age , it has been demonstrated that 1 ) there are no changes in either alpha 2- or beta-adrenergic receptor density or receptor antagonist affinity , 2 ) there is decreased beta-adrenergic receptor-agonist affinity with a corresponding decrease in the ability to form the high-affinity binding complex , 3 ) there is no change in alpha 2-adrenergic receptor agonist affinity , 4 ) there is decreased naf- and hormone-stimulated adenylate cyclase activity , 5 ) there is decreased nucleotide regulatory protein function in the rat myocardium , 6 ) there is decreased catalytic unit function , and 7 ) there is decreased translocation of membrane-bound protein kinase .
C0086418
human
C0001643
beta-adrenergic receptor