if these mechanisms fail and tissue necrosis ensues , ( 2 ) replacement of lost tissue is achievable by either the original cells ( e.g. , epithelia ) , by cell migration ( restitution ) and proliferation ( regeneration ) , and/or by connective tissue repair ( e.g. , fibroblasts , collagen ) through cell proliferation and production of extracellular matrix .
C0007634
cells
C0016030
fibroblasts