because of a possible etiologic link between mutations and carcinogenesis , we compared fibroblasts derived from skin biopsies of several patients with hereditary cutaneous malignant melanoma and the dysplastic nevus syndrome for sensitivity to the mutagenic and/or cytotoxic effect of broad-spectrum simulated sunlight and of a uv mimetic carcinogen , 4-nitroquinoline 1-oxide ( 4nqo ) .
C1512419
hereditary cutaneous malignant melanoma
C0013403
dysplastic nevus syndrome