among the earliest responses to mitogens that have been detected in normal quiescent cells are ionic changes : we have described rapid increases in the cytosolic free ca2+ concentration ( [ ca ] i ) and in the intracellular ph ( phi ) in mitogen-stimulated thymocytes and fibroblasts ( hesketh , t. r. , moore , j. p. , morris , j. d. h. , taylor , m. v. , rogers , j. , smith , g. a. , and metcalfe , j. c. ( 1985 ) nature 313 , 482-484 ) .
C0007634
normal
C1383501
cytosolic