it is proposed that malignant transformation can be effected by damage to the microtubular and microfilamentous structures which changes cell constitution and behavior in two ways : ( 1 ) chromosomal instability is introduced which promotes continuous selection for variants better able to resist environmental signals to limit reproduction and ( 2 ) a variety of metabolic defects in biochemical processes such as specific membrane functions are introduced which may alter the growth responses of the cell .
C0025979
microfilamentous
C0007634
cell