we have examined the role of this receptor on human breast cancer growth with a monoclonal antibody ( alpha-ir-3 ) that blocks the receptor binding domain and inhibits igf-i-induced growth . alpha-ir-3 inhibited clonal growth in vitro and blocked the mitogenic effect of exogenous igf-i in both mcf-7 and mda-231 breast cancer cell lines .
C0037657
igf
C0021665
igf-i