these findings permit us to deduce that , at least in culture , the dissolution of fibrin by plasminogen-supplemented ht-1080 cells was mediated by plasminogen-assisted proteolysis which entailed the extracellular conversion of plasminogen to plasmin by cell-derived u-pa , and that the dissolution of collagen fibrils by trypsin-supplemented skin fibroblasts was mediated by a collagenase-dependent pathway .
C0597304
proteolysis
C0032140
plasminogen