by contrast , the area under the plasma concentration versus time curve was much smaller during ( mean 262 nmol/1 x h ) than after ( mean 1298 nmol/1 x h ) pregnancy , resulting in an average apparent oral clearance ( clo ) of metoprolol that was 4.4 times higher during ( 362 ml x kg-1 body-weight x min-1 ) than after pregnancy .
C0025859
metoprolol
C0032961
pregnancy