considering that there is a selective reduction ( approx . 5-fold ) in the activity of the cytosolic transglutaminase present in hepatocellular carcinomas with no change in the activity of the particulate enzyme ( hand et al . ( 1988 ) biochim . biophys . acta 970 , 137-145 ) these results suggests that the two enzymes may be differentially activated and that they may act on different substrates within the cell .
C1383501
cytosolic
C0007634
cell