intraportal administration of insulin doses ( 4 to 8 u . ) insufficient for normalization of hyperglycemia produced a decrease in the energy charge of the liver to a considerably lower level than normal ( p less than 0.01 ) , whereas larger doses ( 20 u . ) of insulin raised the energy charge to normal levels , with a concomitant recovery of mitochondrial oxidative phosphorylation .
C0020456
hyperglycemia
C0021641
insulin