chick embryo fibroblasts serially propagated in media containing division rate-limiting amounts of fetal bovine serum underwent premature culture senescence as illustrated by accelerated declines in the number of cells incorporating 3h-thymidine , increased population doubling times , reduced cell densities at subcultivation , and reduced replicative life-spans compared to cells grown in medium containing non-rate-limiting amounts of serum .
C0016030
fibroblasts
C0007634
cells