secretion products from cultured human cells derived from a small-cell carcinoma of the lung were shown to contain a high molecular weight precursor analagous to pro-opiocortin : this molecule is a polypeptide of the order of 28,000 daltons the enzymatic processing of which leads to the coordinated and simultaneous release of different peptide fragments : acth , beta- and gamma-lipotropins , beta-endorphin , fragment 16 k and gamma 3-msh .
C0033195
pro-opiocortin
C0017046
gamma-lipotropins