in the presence of trilostane , added to the cells in order to block the conversion of pregnenolone to cortisol , the net maximal output of pregnenolone and 17-hydroxypregnenolone in response to acth was significantly increased in adrenocortical cells from acth-treated animals ( 449.5 +/- 35.8 ng pregnenolone and 85.7 +/- 10.5 ng 17-hydroxypregnenolone vs 269.1 +/- 36.3 ng pregnenolone and 43.7 +/- 8.51 ng 17-hydroxypregnenolone for cells from control guinea-pigs ) .
C0373704
pregnenolone
C0376260
17-hydroxypregnenolone