we hypothesized that , during isosmotic isonatremic hcl acidosis with maintained isocapnia in cisternal cerebrospinal fluid ( csf ) , acetazolamide , by inhibiting carbonic anhydrase ( ca ) in the central nervous system ( cns ) , should produce an isonatric hyperchloric metabolic acidosis in csf .
C0001122
acidosis
C0000981
acetazolamide