we have already reported that renal glycine amidinotransferase ( gat ) activity decreases in the course of renal damage , however , the inability of the kidney to synthesize guanidinoacetic acid ( gaa ) may be compensated by the pancreas in a more advanced stage of renal failure , and that in diabetes mellitus , the production of gaa is decreased from the period without renal dysfunction , and the extrarenal production of gaa is also decreased .
C0030274
pancreas
C0011849
diabetes mellitus