it is postulated that the necrosis of hepatocytes packed with electron-dense lysosomes may be due to the accumulation of toxic amounts of copper in the cytosol , resulting from a reduced uptake of copper into the lysosomal system of these cells , and that the susceptibility of liver cells to cu-induced damage may be increased if lysosome production is diminished .
C0007634
cells
C0024369
lysosome