cardiac beta-adrenoceptors were studied in membrane fractions from spontaneously hypertensive rats ( shr ) and rats with two-kidney , one clip hypertension ( 2k , 1c ht ) , using radioligand binding method . beta-adrenoceptor concentration measured by [ 3h ] -dihydroalprenolol ( dha ) binding was significantly lower in cardiac membranes from two months old shr than those from wistar-kyoto rats ( wky ) ( 38.2 +/- 2.6 vs 45.1 +/- 1.8 fmol/mg protein , means +/- sem , p less than 0.05 ) .
C0020538
hypertension
C0001643
beta-adrenoceptor