it is concluded ( a ) that the steady-state level of rar-alpha mrna is not tightly correlated with natural responsiveness/unresponsiveness or , in some instances , acquired resistance to ra-induced differentiation and ( b ) that further studies are needed to determine if the mean 1.7-fold higher rar-alpha mrna level in apl cells could be an essential factor in the ra-responsiveness of apl cells , as primarily regulated at a different molecular level .
C0007589
differentiation
C0007634
cells