activation requires the recruitment of new osteoclasts derived from precursor cells of the mononuclear phagocyte system ( and so ultimately from the hematopoietic stem cell ) , a method for precursor cells to penetrate the cellular and connective tissue barrier of the quiescent surface , and so gain access to the bone mineral , and mechanisms for their attraction and binding to the mineralized surface , possibly in response to chemotactic signals released from bone matrix or mineral .
C0262950
bone
C0005962
bone matrix