we have studied gonadal function in five patients ( three men and two women ) who received high-dose methotrexate ( hd-mtx ) alone and in 12 patients ( seven men and five women ) who received hd-mtx and vincristine ( vcr ) as postoperative adjuvant therapy for osteosarcoma .
C0025677
hd-mtx
C0029463
osteosarcoma