conformational changes of hexokinase from ascites tumor cells have been studied by chemical modification of lysine residues with imidoesters with the following results : 1 ) the membrane-bound enzyme , in contrast to the soluble enzyme , is not inactivated by treatment with dimethyl suberimidate , which suggests ( a ) lysine residue ( s ) essential for the activity that is protected in the membrane-bound enzyme .
C0020929
imidoesters
C0012402
dimethyl suberimidate