after 6 wk of exposure to no2 at ambient levels ( 0.35 +/- 0.05 ppm ) , the following significant changes were observed in the spleens of exposed mice : ( 1 ) increase in % spleen weight ( p less than 0.0025 ) , ( 2 ) increase in size of spleen lymphoid nodules ( p less than 0.01 ) , ( 3 ) smaller increase in spleen cell number per given weight increment of spleen as determined by correlation coefficients ( p less than 0.0125 ) and linear regression analysis of spleen cell counts , and ( 4 ) an apparently greater predominance of red cells in the red pulp .
C0037993
spleen
C0229687
red pulp