a controlled study of 226 age-matched patients with histologically proven grade 3 and 4 supratentorial gliomas with maximum feasible tumour resection , postoperative karnofsky performance over 50 and minimum survival of 8 weeks compares the results of supportive care ( 45 cases ) , high-dose irradiation of 40 to 66 gy ( 59 cases ) , comp protocol ( ccnu , procarbazine , vincristine , methotrexate , prednisone in 15 day cycles-42 cases ) and simultaneous irradiation and comp chemotherapy ( 80 cases including 30 survivors ) .
C0025677
methotrexate
C0056167
comp