it is proposed that , in the absence of ruthenium red , the transmission of changes in cytoplasmic ca2+ across the mitochondrial inner membrane is able to maintain the phosphorylation potential of the heart during positive inotropic stimulation , through activation of the ca2+-sensitive intramitochondrial dehydrogenases ( pyruvate , nad+-isocitrate and 2-oxoglutarate dehydrogenases ) leading to enhanced nadh production .
C0010834
cytoplasmic
C0230840
mitochondrial inner membrane