this finding of extensive homology of polysomal poly ( a ) mrna and total nuclear rna between normal and neoplastic cells , together with our previous finding of extensive homology of the major 35s-labeled nuclear or cytoplasmic polypeptides observable on two-dimensional gels [ leavitt , j. c. , & moyzis , r. k. ( 1978 ) j. biol . chem . 253 , 2497-2500 ] , demonstrates that the phenotypic changes associated with neoplastic transformation by chemical carcinogens are accompanied by relatively few changes in the qualitative pattern of gene expression in cells cultured in vitro .
C0010834
cytoplasmic
C0007634
cells