based on in vivo studies on isolated muscle strips of the les and on manometric in vivo studies on 8 mongrel dogs , 6 healthy volunteers , 6 patients with achalasia and 3 subjects with diffuse esophageal spasm we could demonstrate that nifedipine causes a long-lasting relaxation of smooth muscle , the esophagus and les .
C0014876
esophagus
C0227192
les