the effect of quinidine on the distribution and elimination of digoxin was examined by comparing the change in the steady-state volume of distribution ( vdss ) , determined both from in vivo plasma elimination and tissue distribution and in vitro serum binding studies , with that in the total body clearance ( cltot ) determined from biliary , renal , and metabolic clearances in guinea pigs .
C0032105
plasma
C0229671
serum