replacement of amino acid residue ser-145 ( the autophosphorylation site of yeast r ) with ala or gly produced mutants which were 2-10-fold better inhibitors of c , while replacement with glu , asp , lys , or thr produced mutants which were 2-5-fold worse inhibitors of c relative to wild type r .
C0002520
amino acid
C0017890
gly