in order to quantify changes in vessel permeability seen previously in experimental astrocytomas produced in rats by an intracerebral injection of cultured neoplastic glial cells , the flux of mannitol across the vascular endothelium from the blood into the normal brain or tumour tissue was measured using a specially devised technique by which a steady level of radioactively labelled mannitol can be achieved rapidly and maintained in the bloodstream .
C0006104
brain
C0205361
steady