we concluded that ( a ) patients with zollinger-ellison syndrome without multiple endocrine neoplasia , type 1 or metastasis should undergo exploratory laparotomy and potential resection of identifiable gastrinomas , ( b ) chronic therapy with h2-receptor antagonists is preferable to total gastrectomy and satisfactory control may be achieved in most patients , and ( c ) tumor death is currently the major threat to survival for patients with unresectable gastrinomas , particularly nonmultiple endocrine neoplasia , type 1 .
C0027662
multiple
C0014132
endocrine neoplasia