cefoxitin , n-formimidoyl thienamycin ( mk0787 ) , clavulanic acid , and penicillanic acid sulfone ( cp45,899 ) were studied to determine their potency as suicide inhibitors of three very different kinds of beta-lactamases produced by gram-negative bacteria : type ib penicillinase ( tem-2 type ) , a typical cephalosporinase ( the enzyme of proteus morganii ) , and a cephalosporinase with broad substrate specificity ( the enzyme of proteus vulgaris ) .
C0038665
penicillanic
C1373040
inhibitors