these data along with other published results suggest that chemicals known to disrupt nucleotide biosynthesis , alter deoxyribonucleotide pools , or directly inhibit dna polymerase can cause stable , heritable increases in tft resistance through mechanisms dependent upon altered replicative dna synthesis , yet not necessarily dependent upon dna incorporation or the binding of these mutagenic agents to nuclear dna .
C0598312
dna synthesis
C0012854
dna