to study the role of endothelial damage in the pathogenesis of lung injury induced by the pyrrolizidine alkaloid monocrotaline , three functions ( angiotensin converting enzyme ( ace ) activity , plasminogen activator ( pla ) activity , and prostacyclin ( pgi2 ) production ) associated with the pulmonary endothelium were examined , and were correlated with pulmonary arterial perfusion and ultrastructure in rats receiving monocrotaline in their drinking water ( 20 mg/liter ) for 1-12 weeks .
C0034335
pyrrolizidine alkaloid
C0085241
monocrotaline