skin from patients with inherited disorders of connective tissue metabolism ( eds types i-ix , marfan 's syndrome , osteogenesis imperfecta , spondyloepiphyseal dysplasia , and cutis laxa ) has been examined by light and transmission electron microscopy for defects in the collagen and elastic fibrous connective tissue which may explain the clinical disorder and/or correlate with the biochemical defect ( where known ) .
C0410787
inherited disorders of connective tissue
C0029434
osteogenesis imperfecta