since na+ , k+-atpase plays a central role in neuronal function , and the presence of excess phe and its deaminated metabolites occurs in brain tissue under conditions of experimentally induced hyperphenylalaninemia and genetic phenylketonuria , the neurologic impairment in experimental and genetic pku may in part be related to the deleterious effects of these compounds on brain atpase .
C0001479
na
C0001473
atpase