in fed obese hyperglycaemic mice ( ohm ) , which are a good model of the human obesity-associated diabetes , hepatic fructose-1,6-diphosphatase ( f16pase ) and glucose-6-phosphatase ( g6pase ) , involved in glucose production , showed increased activity ( +52 and +200 per cent , respectively ) compared to control mice ( cm ) , and the ratios of f16pase and g6pase to the opposing enzymes phosphofructokinase ( pfk1 ) and glucokinase ( gk ) , i.e . the f16pase/pfk1 and g6pase/gk ratios , were increased by 38 and 101 per cent , respectively , suggesting increase in gluconeogenesis and perhaps in glycogenolysis .
C0017725
glucose
C0017715
gluconeogenesis