data reviewed here indicate that acute and chronic ethanol ingestion induce a decrease in the concentration of gsh and an increase in lipoperoxidation in the liver both in experimental animals and in man , changes that are closely interrelated gsh depletion is suggested to be due to an oxidation in the liver tissue and to a translocation into the extrahepatic medium as free glutathione and/or as conjugates with ethanol-derived acetaldehyde .
C0023884
liver
C0736268
liver