with the assumption of linear kinetics and a 1-compartment open model , analysis of the data showed that the volume of distribution ( vd ) and plasma clearance ( cl ) but not plasma half-life ( t 1/2 ) were higher in orientals than caucasians : [ vd = 480 +/- 24 ( sem ) and 292 +/- 36 1/70 kg ; cl = 79 +/- 7 and 51 +/- 7 1/70 kg/hr ; t 1/2 = 4.1 +/- 0.4 and 4.3 +/- 0.4 hr ] .
C0022702
kinetics
C0018517
half-life