the internal regulation of mast cell-dependent phenomenons occurs at at least four levels : 1 ) the intensity and nature of the activating stimulus , 2 ) the regulation of mediator generation and release of cellular levels of the cyclic nucleotides , 3 ) the capacity of target cells to bind and respond to primary mediators , and 4 ) the rate at which mediators undergo biodegradation .
C0596286
the
C0007634
cellular