irreversible changes of potential developmental significance observed after vitrification at the gv stage include ( i ) premature chromosomal condensation , ( ii ) mixing of nucleoplasmic and cytoplasmic components prior to gv breakdown , and ( iii ) externalization of chromatin fragments into the cytoplasm after reformation of the oocyte nucleus , which shows the potential for the generation of fertilizable oocytes containing deleted segments of dna .
C0682537
nucleoplasmic
C0007610
nucleus