the metabolism of dht by epidermal keratinocytes resulted in the formation of 5 alpha-androstanedione , 5 alpha-androstane-3 alpha,17 beta-diol , 5 alpha-androstane-3 beta,17 beta-diol , androsterone , and isoandrosterone : the rates of formation of 5 alpha-androstane-3 alpha,17 beta-diol and 5 alpha-androstane-3 beta,17 beta-diol were linear with incubation time up to 24 h , and the specific activities of 3 alpha-hsor and 3 beta-hsor did not appear to change with keratinocyte time in culture up to 3 weeks .
C0014520
epidermal
C0022567
change