we further suggest that the high selectivity of potent renin inhibitors known to be only weak pepsin and cathepsin d inhibitors is due in part to the extent of histidine protonation at p2 arising from ph differences in the inhibition kinetics assay of renin ( neutral conditions ) compared to other aspartic proteinases ( acid ph 2-4 ) .
C0035094
renin
C2717969
aspartic proteinases