the concentration of gamma-hydroxybutyrate ( ghb ) in brain , kidney , and muscle as well as the clearance of [ 1-14c ] ghb in plasma have been found to be altered by the administration of a number of metabolic intermediates and drugs that inhibit the nadp+-dependent oxidoreductase , `` '' ghb dehydrogenase , '' '' an enzyme that catalyzes the oxidation of ghb to succinic semialdehyde .
C0086045
concentration
C0006104
brain