a prospective randomized trial using the group sequential statistical method with frequent planned interim analyses was initiated in patients with metastatic colorectal adenocarcinoma comparing methotrexate and 5 fluorouracil ( mtx-fu ) to methyl ccnu , vincristine , fu , and streptozotocin ( mof-strep ) .
C0036637
methyl ccnu
C0066687
mof-strep