when normal human polymorphonuclear leukocytes were preincubated with cytochalasin b ( to minimize endocytosis ) and then exposed to the surface-active lectin , concanavalin a , the cells were stimulated to generate o-2- in a concentration- and time-dependent fashion and selectively to discharge the granule-associated enzyme , lysozyme , into the surrounding medium .
C0014139
endocytosis
C0007634
cells