these results show that in this system bleomycin and talisomycin analog treatment of linear pm2 or pbr322 dna resulted in breakage of dna , producing different-length dna fragments , and demonstrate the importance of the two amino acids and the 4-amino-4,6-dideoxy-l-talose sugar , which are located near the bithiazole in talisomycin but absent in the bleomycin structure in conferring a different site-specificity for dna fragmentation to talisomycin than to bleomycin .
C0012854
dna
C0000702
a