incubation of human astrocytoma cells ( 1321n1 ) with low concentrations of isoproterenol results in a specific loss of responsiveness to catecholamines as evidenced by a decreased accumulation of camp in intact cells , a reduction in isoproterenol-stimulated adenylate cyclase activity , and a decrease in beta-adrenergic receptor density , as measured by the specific binding of 125i-hydroxybenzylpindolol .
C0007412
catecholamines
C0022245
isoproterenol