we show that w37 , wv and w41 are the result of missense mutations in the kinase domain of the c-kit coding sequence ( w37 e -- -- k at position 582 ; wv t -- -- m position 660 and w41 v -- -- m position 831 ) , which affect the c-kit associated tyrosine kinase to varying degrees .
C0031727
kinase
C0033681
tyrosine kinase