the major criterion for the successful transmission of the disease in the laboratory strains of mice is inoculation of high titer ecotropic virus in fv-1n strains of mice at newborn stage ( less than or equal to 1 day old ) , hybridization studies using 1504 m viral cdna as probe indicate that in nonparalyzed mice , the inoculated virus replicates primarily in spleen tissue , whereas virus replication is evident in both spleen and central nervous system ( cns ) tissue of paralyzed mice .
C0771377
spleen tissue
C0037993
spleen