mtx ( g5 ) -poly-l-lys-52000 was approximately 1000 times more effective than mtx ( g5 ) -poly-d-lys-52000 in inhibiting the growth of h35r hepatoma cells in culture , indicating that internal cleavage of the gamma-glutamate chain of the conjugate with subsequent release of mtx or shorter chain polyglutamates of mtx is unlikely to be an important determinant of mtx-polyglutamate polylysine cytotoxicity .
C0024337
lys
C0032518
polylysine