the ability of nicotinamide and diethylnicotinamide to interact with cytochrome p-450 underlies their antagonism with respect to in-vitro metabolism of the substrates of both type i ( amidopyrine ) and type ii ( aniline ) as well as with respect to the competition with co for the common center of binding on the enzyme .
C0010762
cytochrome p-450
C0025519
metabolism