we previously reported ( lambeth , j. d. , xu , x. x. , and glover , m. ( 1987 ) j. biol . chem . 262 , 9181-9188 ) that exogenously added cholesterol sulfate inhibits the conversion of cholesterol to pregnenolone in isolated adrenal mitochondria , and does so by affecting intramitochondrial cholesterol movement but not its subsequent metabolism to pregnenolone by cytochrome p-450scc .
C0025519
metabolism
C0008381
cytochrome p-450scc