since the degradation of tg and its stimulation by me are known to depend on the mean iodine content of the molecule , it was concluded that : 1 ) the recently iodinated tg population contains both poorly and fully iodinated molecules , the degradations of which are faster or similar to that of 48 h-iodinated tg , respectively , 2 ) among thyroid phagolysosomes , only those which exhibit a ph-dependent proteolytic activity contain poorly iodinated molecules while others , which are functional at either ph , contain solely fully iodinated molecules ( 1 and 48 h labelled ) , 3 ) reduction of the disulphide bridges of fully iodinated tg , mediated by me and probably a lysosomal transhydrogenase , is a prerequisite for its optimal degradation by lysosomal proteinases , 4 ) in addition , tsh , which preferentially stimulates the degradation of fully iodinated tg , was concluded to interfere directly upon the intralysosomal hydrolytic process , independently of its effect upon tg endocytosis .
C0040132
thyroid
C0040123
tg