human adipocytes from patients with chronic endogenous hypercortisolism ( cushing 's syndrome ) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers ( cushing 's 180,000 +/- 48,000 ( 3 ) receptors/cell and controls 189,000 +/- 30,000 ( 7 ) ) together with a fourfold decrease in apparent receptor affinity ( ed50 : cushing 's 2.25 x 10 ( -9 ) m and controls 0.57 x 10 ( -9 ) m ) and a decreased sensitivity to the antilipolytic effect of insulin .
C0001622
hypercortisolism
C0010481
cushing 's syndrome