each of six patients with beta +-thalassemia produced normal amounts of globin alpha and beta [ 3h ] mrna during a 20-min pulse incubation , but the beta/alpha [ 3h ] mrna ratio declined to steady-state levels during a chase incubation , suggesting posttranscriptional defects in beta-globin mrna metabolism . beta-globin mrna precursor production was estimated by measurement of [ 3h ] rna sequences hybridizing to a pure dna probe containing only the large intervening sequence ( intron ) of the beta-mrna precursor .
C0035668
rna
C0035696
mrna