the sequential exposure of cells to 1.5 x 10 ( -8 ) m vincristine ( vcr ) or vindesine ( vds ) followed by 2 x 10 ( -8 ) m 1,2-dihydroxy-9,10-anthracenedione ( dhad ) or 3 x 10 ( -7 ) m adriamycin ( adr ) had at best an additive effect , demonstrated by isobologram analysis , when the two drugs were given 6 hours apart .
C0003174
anthracenedione
C0026259
dhad