our data show that , in patients with php , ( a ) fibroblast membranes show a decreased complement of g units , ( b ) membrane catalytic activity is normal , but adenylate cyclase activity is reduced when stimulated by hormone or by effectors which activate the g unit , ( c ) the ability of cells to accumulate camp in response to hormone stimulation is reduced , and ( d ) reduced membrane adenylate cyclase activity correlates well with impaired cellular camp synthesis .
C0016030
fibroblast
C0007634
cellular