the drug was applied to 3 patients , 18 to 25 years of age , with wilson-konovalov disease ( hepatolenticular degeneration ) who in the course of chronic d-penicillamine treatment developed drug intolerance with signs of nephrotoxicity ( in one patient ) and myelotoxicity with leucopenia and thrombocytopenia ( in two patients ) .
C0019202
hepatolenticular
C0030817
penicillamine