alginate fed at 25 % ( w/w ) of the diet was nephrotoxic to mice , as shown by extremely high water consumption , high urine production , urinary incontinence , high ph and low specific gravity of the urine , increased level of blood urea nitrogen , increased kidney weights , distension of the renal calyx and the high incidence of dilated distal tubules .
C0022646
kidney
C0022651
renal calyx