following observation of the predictive value of the histologic extent of tumor cell destruction after preoperative chemotherapy for metastasis-free survival ( mfs ) in osteosarcoma , a randomized study was undertaken with the aim of ( 1 ) sparing some patients the unpleasant side effects of highly toxic drugs like doxorubicin ( dox ) and cisplatin ( cpdd ) by administering these drugs postoperatively only after poor response with a milder preoperative regimen , and ( 2 ) improving the prognosis of patients responding poorly to the initial treatment by use of a salvage chemotherapy postoperatively .
C0029463
osteosarcoma
C0013089
doxorubicin