in a patient with ph-positive chronic granulocytic leukaemia who had 3 separate episodes of promyelocytic transformation associated with new cytogenetic and genetic changes dna from the peripheral-blood leucocytes obtained during the second episode of transformation showed an 8-fold to 16-fold amplification of cellular myc proto-oncogene ( c-myc ) sequences , and rearrangement of these sequences .
C0229664
peripheral-blood
C0023516
leucocytes