a ) in mice , a single ip administration of the ld50 of the three drugs caused a small but statistically significant increase over controls in dna elution rate , ie , a modest amount of dna fragmentation , in three of the four organs ( liver , lung , kidney , and spleen ) tested , dna damage being absent in lung for hydralazine and endralazine and in liver for dihydralazine .
C0020223
hydralazine
C0012271
dihydralazine