histamine release stimulated by one or more of these agents ( 1 ) occurred in normal and metabolically inactivated cells , ( 2 ) had a biphasic time course in normal and inactivated cells , ( 3 ) was temperature dependent and did not occur at 0 degrees c , ( 4 ) was accompanied by concomitant cytoplasmic enzyme release , ( 5 ) was accomplished by substantial cell swelling , and ( 6 ) was correlated with a loss of cell refractility in phase contrast microscopy .
C0010834
cytoplasmic
C0007634
cell