the mechanism of the activation of plasminogen by single-chain urokinase-type plasminogen activator ( single-chain u-pa , scu-pa ) was studied using rscu-pa-glu158 , a recombinant plasmin-resistant mutant of human scu-pa obtained by site-specific mutagenesis of lys158 to glu , and rplg-ala740 , a recombinant human plasminogen in which the catalytic site is destroyed by mutagenesis of the active-site ser740 to ala .
C0042071
u-pa
C0086418
human