we conclude that ( i ) inhibition of egf-induced mitogenesis by amiloride is due not to inhibition of egf-stimulated na+/h+ exchange but rather to inhibition of necessary events occurring during the hours immediately prior to the onset of dna synthesis , these events probably being rna and protein synthesis and ( ii ) in cell culture medium buffered with co2/hco3- , complete inhibition of egf-stimulated na+/h+ exchange does not inhibit egf-induced mitogenesis and , thus , stimulation of na+/h+ exchange is not necessary for induction of mitogenesis by egf .
C0035668
rna
C0597295
protein synthesis