we found that a non-toxic combination of hyperthermia and trifluoperazine : enhanced the cytotoxicity of bleomycin , increased the frequency of long-lived attachment sites of cellular dna at the nuclear matrix , and resulted in an accumulation of dna damage ( strand-breaks and alkali-labile lesions ) caused by the inhibition of strand-break rejoining and the impaired processing of dna sites involving base loss .
C0007634
cellular
C0028581
nuclear matrix