to test this hypothesis and to differentiate between er-mediated and general cytotoxic effects of tam , the growth-inhibitory effects of tam and its in vivo metabolite 4-hydroxytamoxifen ( oh-tam ) have been studied in five continuous human cancer cell lines , mcf7 and t47d ( mammary carcinoma , er positive ) , bt20 and mda-mb-231 ( mammary carcinoma , er negative ) , and me8 ( melanoma , er negative ) .
C0006826
cancer
C0025202
melanoma