these results suggest that furosemide may increase pge2 synthesis not only by increasing the availability of the substrate arachidonic acid or by inhibiting the action of the catabolizing enzyme 15-hydroxyl-pg-dehydrogenase , as has been proposed , but also by depressing the activity of the enzyme pge2-9-ketoreductase , which catalyzes the conversion of pge2 to pgf2 alpha .
C0033554
pg
C0012472
pge2