the frequently encountered findings are : upward-slanted eyes , small palpebral fissures , enophthalmos or microphthalmos , broad base and prominent tip of the nose , microcephaly , micrognathia , low-set malformed ears , high-arched palate , congenital heart disease , skeletal and genito-urinary anomalies , abnormal palmar creases , failure to thrive , hypotonia and retardation .
C0000768
malformed
C0042063
genito-urinary