a role for the direct toxicity of the drug is likely because ( a ) toxicity in part is related to dosage and duration of therapy , ( b ) many patients with amiodarone pulmonary toxicity have no evidence of an inflammatory or immune response in the lung , ( c ) in vitro studies indicate that amiodarone can be directly toxic to cultured lung cells or perfused isolated lung tissue , and ( d ) recent studies suggest plausible biochemical mechanisms that may explain in part the mechanism ( s ) of direct toxicity of the drug .
C0024109
lung
C0819757
lung tissue