globin biosynthesis by erythroblasts of beta-thalassemia heterozygotes was balanced despite the mrna deficiency ( beta/alpha = 0.9-1.0 ) , suggesting that post-translational phenoma ( eg , proteolysis of free globin chains ) , rather than instability of beta mrna , accounts for the balanced globin chain synthesis frequently observed in bone marrow erythroblasts of patients with beta-thalassemia trait .
C0005953
bone
C0014762
erythroblasts