in man assessing paa is difficult due to the presence of an intact sympathetic system : the problem can be overcome by autonomic blockade of constrictor and vagal reflexes with prazosin , clonidine and atropine but leaving the beta-receptor mediated responses unimpaired . beta 1- and beta 2-selective paa can also be gauged via an increased sleeping heart rate ( basal sympathetic tone ) in the presence and absence of a beta 1- and beta 2-selective antagonist . beta 1-selective paa can also cause an increase in resting systolic blood pressure , beta 2-selective paa may be further assessed by a fall in dbp , increased blood flow , fall in peripheral resistance or increased finger tremor .
C0004259
atropine
C0039231
increased