we have found that pretreatment of human neutrophils with phenytoin ( 0.05 to 0.8 mm ) results in concentration-dependent , reversible inhibition of both superoxide anion generation and release of lysosomal enzymes ( myeloperoxidase , lysozyme , beta-glucuronidase ) provoked by either the synthetic peptide , n-formyl-methionyl-leucyl-phenylalanine ( fmlp ) or the complement fragment c5a .
C0086418
human
C0027021
myeloperoxidase