the covalent binding of benzo [ a ] pyrene ( b [ a ] p ) to acid extractable chromosomal proteins and the subsequent effect on histone 1-dna interaction have been characterized in a model system by utilizing calf thymus nuclei as targets and rat liver microsomes as an exogenous source of enzymes for the metabolic activation of b [ a ] p .
C0019652
histone
C0007610
nuclei