the administration of mevalonic acid to rats by intravenous injection resulted in a dose- and time-dependent increase in the activity of cholesterol 7alpha-hydroxylase in the liver microsomal fraction , a decrease in the microsomal activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and no significant change in the activity of acyl-coenzyme a : cholesterol acyltransferase or in the concentration of free and of esterified cholesterol in the liver microsomal fraction .
C0009226
a
C0001374
acyl-coenzyme a