both the acute and chronic ( 40 days ) administration of nicotine ( 0.4 mg/kg s.c. ) caused a decrease in the rate of formation of 5-ht by hippocampal synaptosomes ( p less than 0.05 ) while 24 h withdrawal of the drug from chronically treated rats resulted in a partial recovery of this effect .
C0028040
nicotine
C0038587
withdrawal