the intracellular : extracellular concentration ratio for the 2-nitroimidazole , misonidazole was constant at about 0.7 for phe = 6.6-7.6 , whereas the weak base , ro 03-8799 ( 1- ( 2-nitro-1-imidazolyl ) -3-n-piperidino-2-propanol ) was concentrated intracellularly at phe = 7.3-7.4 by a factor of 3.3 , the factor increasing from about 0.8 at phe = 6.0 , to 7.5 at phe = 7.85 .
C0028179
nitroimidazole
C0026218
misonidazole