these findings suggest that changes in l1210 ca2+ homeostasis induced by adriamycin and menadione are late , and possibly common , events of quinone toxicity to l1210 cells , adriamycin does not have an immediate effect on ca2+ ion transport produced by the direct interaction of the antibiotic with the plasma membrane , and oxidative stress induced by redox-active quinones may not be important for the induction of toxicity in neoplastic cells .
C0007634
cells
C0007603
plasma membrane