the subcellular distribution studies in brains of tolerant and non-tolerant rats indicated that an accelerated shift in the concentrations of delta-9-thc and 11-oh-delta-9-thc towards highly polar metabolites in the brains , rather than an increased elimination of these cannabinoids or decreased sensitivity of the brain may be responsible for the development of tolerance to delta-9-thc .
C0006864
cannabinoids
C0039663
thc