there are a number of possible mechanisms by which chemicals might induce aneuploidy , including effects on microtubules , damage to essential elements for chromosome function ( ie , centromeres , origins of replication , and telomeres ) , reduction in chromosome condensation or pairing , induction of chromosome interchanges , unresolved recombination structures , increased chromosome stickiness , damage to centrioles , impairment of chromosome alignment , ionic alterations during mitosis , damage to the nuclear membrane , and a physical disruption of chromosome segregation .
C0242961
origins of
C0008633
chromosome