for example , such factors as hormones ( cortisol , progesterone , and estrogen ) , pregnancy-associated glycoproteins ( alpha 2-macroglobulin and beta 1-glycoprotein ) and afp , which have immunosuppressive properties , may all serve nonspecifically to inhibit and decrease the general tone of maternal immunologic responses , particularly at the placental interface , where many of these factors are present in high concentrations .
C0033308
progesterone
C0032961
pregnancy