in addition , the fibrinolytic activity of a variant containing the substitutions gln42 -- -- asn , his44 -- -- glu , and asn117 -- -- gln , when compared with wild-type t-pa in an in vivo rabbit venous clot lysis model , was found to have similar lytic efficacy at approximately one-fourth the dose .
C0061472
glu
C0017797
gln