recent reports that describe antigen-independent b cell activation through coculture with t cells activated by anti-t-cell receptor or anti-cd3 antibodies suggest that cellular interaction with t cells , independent of antigen presentation or lymphokine secretion , induces or triggers b cells to become responsive to t-derived lymphokines , and that this may be an integral component of the physiological , antigen- and mhc-restricted t-dependent b cell activation that leads to antibody production .
C0003320
antigen
C1155003
b cell activation