we have found that pretreatment of human neutrophils with ibuprofen ( 0.10-1.0 mg/ml ) results in an irreversible , concentration-dependent inhibition of superoxide anion generation and release of lysosomal enzymes ( myeloperoxidase , lysozyme ) stimulated by the synthetic peptide , n-formyl-methionyl-leucyl-phenylalanine ( fmlp ) , the complement fragment c5a , and to a lesser extent by serum opsonized zymosan .
C0086418
human
C0027021
myeloperoxidase