l1210 leukemic cells of mice were incubated for a period of two generations in the presence of either alpha-methyl- ( +/- ) -ornithine , an inhibitor of ornithine decarboxylase , or methylglyoxal bis ( guanylhydroazone ) , an inhibitor of s-adenosylmethionine decarboxylase . alpha-methyl- ( +/- ) -ornithine produced a 50 % decrease in spermidine levels , reduced putrescine to nondetectable levels , and caused a slight increase in spermine levels of the cells .
C0037871
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C0037874
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