threshold doses for gastro-intestinal ulcerogenicity in rats after single and repeated ( 10x ) doses were found to be 30 mg/kg , p.o. , and prostaglandin ( pge2 ) production in rat gastric and ileal mucosa was only marginally inhibited ( ed50 greater than 30 mg/kg , p.o . ) .
C0033554
prostaglandin
C0012472
pge2