the elevated cmro2 and cbf could be reduced to normal by administration of a beta-adrenergic receptor blocker ( propranolol 2 mg/kg i.v . ) , and hence the increased cmro2 during ethanol withdrawal could be related to catecholaminergic systems in the brain , e.g . the noradrenergic locus coeruleus system which is anatomically well suited as a general activating system .
C0006104
brain
C0023951
locus coeruleus