thus when platelets undergo the release reaction , a form of platelet-to-platelet adhesion occurs that is not disrupted by chelation of divalent cations and is therefore not likely to involve only fibrinogen or thrombospondin and fibrinogen since the association of fibrinogen with its receptor requires ca2+ and the binding of thrombospondin to platelets that have undergone the release reaction is also dependent on ca2+ .
C0076560
thrombospondin
C0005821
platelets