in contrast to erythromycin , erythralosamine and tao , roxithromycin and its metabolite ru 39001 exhibit : ( i ) a very poor affinity for rat liver cytochrome p-450 , ( ii ) an unability to be metabolized into a stable inhibitory metabolite-cytochrome p-450 complex and ( iii ) a decreased ability to induce liver cytochrome p-450 pcne , an isozyme implicated in drug associations involving some macrolide antibiotics .
C0014806
erythromycin
C0035891
roxithromycin