t-antigen production , polyoma-rna synthesis , induction of host dna synthesis ( measured by incorporation of labeled thymidine into the cell culture ) , and in vitro transforming ability were inactivated to a similar degree by various beta-propiolactone concentrations ( 0.25 % beta-propiolactone reduced these functions approximately 96 % ) , whereas plaque-forming ability and the ability of the virus to replicate its dna and to synthesize capsid antigen were inactivated by a given concentration of beta-propiolactone to a much greater degree ( 0.25 % beta-propiolactone led to a reduction of plaque-forming ability of over 8 logs ) .
C0003343
t-antigen
C0042776
virus