thiazolo [ 3,2-a ] thieno [ 3,2-d ] - , [ 3,4-d ] - and [ 2,3-d ] pyrimidin-5-one derivatives ( 6 , 11 and 16 ) , and polymethylene condensed thieno [ 3,2-d ] - , [ 3,4-d ] - and [ 2,3-d ] pyrimidin-5-one derivatives ( 19-21 ) , in which the oxygen atom of the oxazolidine moiety in 3 was replaced by a sulfur atom or methylene groups , were synthesized and evaluated for gastric antisecretory activity in pylorus-ligated rats .
C0038351
gastric
C0034196
pylorus