the enzyme absolutely required atp , coa , a monovalent cation ( k+ , rb+ , cs+ or nh+4 ) and a divalent cation ( mg2+ , mn2+ , ca2+ or ni2+ ) for the activation of acetoacetate , yielding acetoacetyl-coa , amp and pyrophosphate in equimolar amounts .
C0007447
cation
C0007448
divalent cation