the therapeutic concept of irreversible inhibition of both ornithine decarboxylase ( odc ) and s-adenosylmethionine decarboxylase ( samdc ) by alpha-difluoromethylornithine ( dfmo ) and methylglyoxal bis-guanylhydrazone ( mgbg ) is based on pathologic activities of these enzymes in tumor tissue .
C0029282
ornithine
C0002260
alpha-difluoromethylornithine