the specificity of this regulation is supported by the evidence that ( 1 ) the degree and topography of the normalization of muscarinic receptor density was entirely dependent on the degree and pattern of cholinergic reinnervation by the fibers of the septal transplant , ( 2 ) cholinergic fiber reinnervation by embryonic striatal grafts also down-regulated the density of m1 and m2 receptors , and ( 3 ) successfully surviving transplants ( e.g. , cerebellar and striatal ) that did not provide innervation to the hippocampus did not induce down-regulation of muscarinic receptors .
C0034826
muscarinic receptor
C0384752
m2 receptors