fsgh is characterized by a severe nephrotic syndrome , progressive course , and refractoriness to immunosuppressive therapy , focal and segmentary pattern of changes in the glomeruli , the presence of hyalin masses in some lobules of glomerular capillaries , lipid inclusions in mesangial and endothelial cells , tubular epithelial cells and interstitium , as well as uneven outlines of the endothelial surface of the basal membrane of glomerular capillaries .
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