although methicillin-resistant s. aureus strains appear to be universally resistant to smx , the combination tmp-smx was found to be synergistic in vitro ( in combination , the mics of both drugs decreased 6- to 25-fold ) as well as in vivo ( 5- to 6-fold reduction in tmp at 50 % effective doses ) .
C0038689
smx
C0041044
tmp-smx