in experiments on cba/lac j mice it was found that the course administration of adriamycin ( 0.95 mg/kg ) , vinblastine ( 0.24 mg/kg ) and cyclophosphan ( 27 mg/kg ) in 1/10 ld50.10 causes persistent disturbances of the functional activity of the lymphoid tissue manifesting by inhibition of the proliferative response of the spleen lymphocytes to t- and b-cell mitogens one month and to a lesser extent three months after cytostatic action .
C0024296
lymphoid tissue
C0024264
lymphocytes