in the urine of normal subjects who were given an oral dose of 500 mg spironolactone ( 3- ( 3-oxo-7alpha-acetylthio-17beta-hydroxy-4-androsten-17alpha-yl ) -propionic acid gamma-lactone ; aldactone ) together with 100uci h-20 , 21 spironolactone , a so far unknown major metabolite has been detected by thin layer chromatography .
C0022947
lactone
C0037982
spironolactone