although further study of the chromosome changes in carcinomas is essential to an understanding of their relationship to the molecular changes that are associated with malignant transformation , it can be hypothesized that , while some of the changes result in the duplication of particular genes , e.g. , on chromosome 1q , a more important role may be to bring about the loss of chromosomal segments containing tumor-suppressor genes .
C0008633
chromosome
C1327882
chromosome 1q