causes include resorption of bone mass ( osteoporosis ) , reduction of bone quality ( osteomalacia , osteonecrosis ) , insufficient bone production ( osteogenesis imperfecta , fibrous dysplasia ) , augmented bone resorption ( giant cell granulomas , aneurysmal bone cyst ) , pathological bone remodelling ( paget 's disease ) , or local bone destruction due to tumorous growths .
C0029445
osteonecrosis
C0262950
bone