these groups were ( 1 ) subjects studied because of multiple miscarriages , ( 2 ) parents of live borns with autosomal trisomy , ( 3 ) subjects studied because they had a relative with down syndrome , ( 4 ) an age-matched control group of phenotypically normal adults studied for other reasons ( e.g. , parent of a dysmorphic child or member of a translocation family ) , and ( 5 ) other mostly younger and phenotypically abnormal subjects who could not be assigned to the first four groups ( e.g. , individuals with multiple congenital anomalies or mental retardation ) .
C0013080
down syndrome
C0000772
multiple