six patients ( four women and two men ) with mild to moderate hypercholesterolemia , but with no clinical evidence of the disease being monogenic familial hypercholesterolaemia and who , over the previous 3 months on a rigidly controlled hypolipidaemic diet therapy , showed no reduction in plasma cholesterol levels , were recruited into a study to assess the metabolic effects of pirozadil , a new nicotinic acid derivative .
C0020443
hypercholesterolemia
C0027996
nicotinic acid