antimicrobial therapy consisted of cefoperazone , cefoperazone plus sulbactam , ciprofloxacin , clindamycin , metronidazole ( against the gram-negative anaerobes ) , or penicillin g ( against the gram-positive anaerobes ) , beginning 4 hours after organism inoculation and continuing every 6 hours for 16 doses .
C1136254
antimicrobial
C0025872
metronidazole