four of these seven patients developed a marked increase in osteoid as judged by bone biopsy , while in the nonfluoridated group the amount of osteoid remained within normal limits.in the absence of fluoride , although osteitis fibrosa occurred , it was reversible in 10 out of 12 cases by dihydrotachysterol treatment , and overall there was no evidence of progression of bone disease at the end of the study period .
C0682561
osteoid
C0262950
bone