eighteen patients with cushing 's syndrome ( 16 pituitary-dependent cushing 's disease , 1 ectopic acth syndrome , 1 primary adrenal adenoma ) were given a combination of aminoglutethimide and metyrapone , with the object of controlling cortisol overproduction using less toxic doses than would be required with each drug alone .
C0010481
cushing 's syndrome
C0001622
of