in the case of digoxin , digitoxin , and strophanthin the retention is directly related to the normal renal clearance of these cardiac glycosides : strophanthin has the highest clearance and the most marked prolongation of pharmacological action in renal failure , whereas digitoxin shows the lowest renal clearance and even in uremic patients a total elimination comparable to normal subjects as a result of increased hepatic clearance ;
C0012265
digoxin
C0007158
cardiac