analysis of plasma and brain samples by high performance liquid chromatography ( hplc ) for concentrations of bupropion ( bup ) and its major basic metabolites , the erythro-amino alcohol ( eb ) , the threo-amino alcohol ( tb ) and the hydroxy metabolite ( hb ) revealed greater accumulation of bup , tb , and hb in plasma and brain of the animals with renal failure compared to controls .
C0086045
concentrations
C0006104
brain