the soluble analogue , n-trifluoroacetyladriamycin-14-o-hemiadipate , did show marked effects on terbium fluorescence with all nucleic acids and nucleosomes , but the effects were generally not as striking as were those observed with the epimer , 4'-epi-adriamycin , which tended to produce a similar effect to its parent drug , adriamycin , showing that a marked change in the hexose ring did not appreciably affect the interaction of the drug with dna .
C0028606
nucleic acids
C0012854
dna