alzheimer patients dying at younger age ( less than or equal to 80 ) with profound decrease in choline-acetyltransferase activity ( by 61-85 % ) and without any , possibly mrb modifying , drug treatment showed 30 % decrease in mrb in the frontal cortex ( p less than 0.05 ) , 28 % in the temporal cortex ( p less than 0.05 ) and 37 % in the hippocampus ( p less than 0.01 ) .
C0039485
temporal
C0019564
hippocampus