at maximal exercise before dobutamine , all patients were limited by fatigue and had reduced maximal systemic oxygen uptake ( 11.9 +/- 1.1 ml/min/kg ) ( +/- standard error of the mean ) , markedly elevated leg oxygen extraction ( 85 +/- 2 % ) and elevated femoral venous lactate ( 53 +/- 5 mg/dl ) , consistent with impaired nutritive flow to working muscle .
C0023216
leg
C0015809
femoral