large , sustained reductions in o2 affinity of hemoglobin are induced best by primary ( non-bohr effect ) stimulation of red blood cell 2,3-diphosphoglycerate ( dpg ) caused by a dual , cumulative effect on o2 affinity for hemoglobin , direct , from dpg itself , and indirect , from dpg-induced red blood cell acidosis .
C0019046
hemoglobin
C0014792
red blood cell