the metabolic clearance rate ( mcr ) of human calcitonin was measured in 12 normal subjects and four patients with paget 's disease by the infusion of synthetic human calcitonin ( 15-40 microgram/h for 2-24 h ) , and in 10 additional patients with paget 's disease from the disappearance rate of immunoreactive calcitonin from plasma after the intravenous injection of large doses of synthetic human calcitonin ( 0.5-1.0 mg ) .
C0029401
paget 's disease
C0006668
calcitonin