we report the case of a 73-year-old patient in whom a diagnosis of creutzfeldt-jakob disease , suggested by the clinical course , was verified by the neuropathologic finding of widespread spongiform change and astrogliosis , the presence of proteinase-resistant protein in brain extracts , and the experimental transmission of spongiform encephalopathy to primates inoculated with brain tissue .
C0011900
diagnosis
C0037088
finding