in previous studies it had been shown that during longterm treatment of coronary artery disease with isosorbide dinitrate ( isdn ) in sustained-release form , there was no reduction in exercise-induced st-segment depression , no decrease in the rate of anginal attacks or nitrate consumption and no changes in blood pressure or heart rate [ 1 , 4 ] .
C0022252
isosorbide dinitrate
C0028125
nitrate