the basis of the trial was : ( 1 ) the hypothesis that excitatory amino acid neurotransmission mediates the neuronal degeneration of hd , ( 2 ) preclinical evidence that baclofen retards corticostriatal release of glutamate and aspartate , and ( 3 ) reports that baclofen produces short-term clinical benefits in some hd patients .
C0020179
hd
C0004609
baclofen