for the non-adrenergic inhibitory response , optimal stimulation parameters were a pulse width of 2 ms , a stimulation period of 12 s and a frequency of 20 hz.5 evidence obtained with pharmacological antagonists , enzyme inhibitors and activators suggested that the transmitter mediating the non-adrenergic inhibitory nervous response is unlikely to be : acetylcholine , histamine , 5-hydroxytryptamine , cyclic 3',5'-adenosine monophosphate or a prostaglandin.6 the adenosine uptake blocking drugs dipyridamole , hexobendine and dilazep potentiated the non-adrenergic inhibitory nervous response and unmasked inhibitory responses to adenosine and adenosine 5'-triphosphate.7 it is concluded that electrical stimulation of the guinea-pig trachea , in addition to activating cholinergic and adrenergic nervous pathways , may activate a separate and distinct inhibitory nervous pathway .
C0001443
adenosine
C0001480
adenosine 5