compared with placebo , timolol decreased the weekly number of anginal attacks and the weekly number of nitroglycerin tablets consumed , reduced the resting heart rate , systolic and diastolic blood pressure , and product of systolic blood pressure times heart rate , decreased the heart rate , systolic and diastolic blood pressure , and product of systolic blood pressure times heart rate at the onset of angina pectoris or marked fatigue , prolonged exercise duration , and diminished electrocardiographic evidence of myocardial ischemia .
C0040233
timolol
C0002962
angina pectoris