the glucagon response to the carbohydrate meal during prompt and super normal hyperinsulinemia resulting from the infusion did not differ from that of the control meal , i.e . normal suppression of glucagon by hyperglycemia was not restored by the abundance of circulating insulin.to determine if still higher plasma levels of insulin would overcome the hyposuppressibility of the diabetic alpha cell to hyperglycemia , 0.6 u. per kilogram per hour of insulin was infused at a constant rate for two hours together with 0.6 gm . per kilogram per hour of glucose to prevent hypoglycemia .
C0017687
glucagon
C0020615
hypoglycemia