intraperitoneal administration of four weekly doses of 20 mg/kg busulfan , starting one week after 1500 rad leg irradiation , produced a severe microenvironmental lesion for 6 months reflected by lack of repopulation in femoral marrow to greater than 50 % of normal by msc , hemopoietic stem cells ( cfu-s ) , and granulocyte-macrophage precursors .
C0023216
leg
C0015811
femoral