to test the hypothesis that nighttime and early morning signs and symptoms of air flow obstruction in patients with moderately severe asthma would be better controlled by theophylline given on a once-a-day evening dosing schedule chosen to provide a peak blood level in the early morning than by the traditional twice-a-day dosing schedule designed to maintain levels more constant throughout the 24-hour period , the effects on nocturnal asthma of uniphyl once a day and theo-dur twice a day were studied in 14 patients with moderately severe asthma .
C0039771
theophylline
C0700814
uniphyl