however , the de novo biosynthesis of beta-endorphin and its prohormones beta-lipotropin and pro-opiomelanocortin was increased in the intermediate pituitary and to an even more pronounced degree , in the adenohypophysis , after chronic treatment of rats with ethanol liquid diet , nevertheless , the amounts of opiate-active beta-endorphin were found to be reduced in both lobes of the pituitary : in the adenohypophysis , this was due to a retardation of the enzymatic processing of beta-endorphin from its precursor beta-lipotropin , while in the intermediate pituitary the alpha-n-acetylation of beta-endorphin to opiate-inactive alpha-n-acetyl-beta-endorphin was stimulated .
C0033195
pro-opiomelanocortin
C0023832
beta-lipotropin