this study shows that calpain i irreversibly activates the ca2+ translocation function of the ca2 ( + ) -atpase in reconstituted proteoliposomes by producing a calmodulin-independent active enzyme fragment , while calmodulin antagonizes this activating effect by protecting the calmodulin-binding domain against proteolytic cleavage by calpain .
C1514524
domain
C0006784
calpain