substitution of deuterium for hydrogen on the alpha-carbon of 7-ethoxycoumarin results in an intrinsic isotope effect of approximately 14 during the cytochrome p-448-catalyzed o-deethylation of this substrate ( g. t. miwa , j. s. walsh , and a. y. h. lu ( 1984 ) j. biol . chem . 259 , 3000-3004 ) .
C0011744
deuterium
C0020275
hydrogen