in three patients with neuroblastoma and high circulating levels of dopamine and dopa , we interfered pharmacologically with catecholamine biosynthesis either at the tyrosine hydroxylase or dopa decarboxylase step in an attempt to 1 ) improve the efficacy of antitumor therapy and 2 ) avoid the potential arrythmogenic interaction between elevated circulating catecholamines and an halogenated hydrocarbon anesthetic during surgery .
C0013023
dopa
C0007412
catecholamines