because the amidolytic activity of human thrombin as well as factor xa , kallikrein , and bovine trypsin was also reversibly suppressed by ferrous sulfate as well as ferric citrate , we consider it likely that the coagulopathy occurring in iron poisoning is the consequence of a general , physiologically important phenomenon : the susceptibility of serine proteases to nontransferrin-bound fe3+ .
C0041236
trypsin
C0036734
serine proteases