rapid protamine reversal of heparin anticoagulation in awake sheep caused , after 1 min , a approximately 15-fold increase of arterial plasma thromboxane b2 ( txb2 ) levels , a 4-fold rise of pulmonary vascular resistance ( pvr ) , a 2-fold rise of pulmonary arterial pressure , and after 3 min , a 2-fold rise of ovine arterial plasma complement c3a levels ( p less than 0.05 ) .
C0033603
protamine
C2917126
reversal