pretreatment with methotrexate ( 10 microm ) , resulting in the formation of methotrexate polyglutamates , or continuous incubation with trimetrexate ( 1 microm ) inhibited growth of folate-depleted l1210 cells in the presence of folic acid or 5-formyltetrahydrolate .
C0025677
methotrexate
C0016410
folic acid