to complement a study on aminoglycoside dosing regimen and ototoxicity in the guinea pig , we designed an experiment to examine : ( 1 ) the effect of dosing regimen on guinea pig pharmacokinetic parameters , and ( 2 ) possible differential accumulation after repeated intramuscular administrations of netilmicin and amikacin ( 150 mg/kg/day ) for 7 days by 1 or 3 daily injections .
C0002556
aminoglycoside
C0002499
amikacin