the hypotension and bradycardia induced by adrenaline ( 10 microgram i.c.v . ) were unaffected by alpha-antagonist pretreatment , while beta-antagonist pretreatment with ( -- ) -propranolol or metoprolol was effective against adrenaline but not clonidine-induced hypotension and bradycardia .
C0020649
hypotension
C0025859
metoprolol