fixed negative charges located on endothelial cells , basement membrane , and interstitial matrix could explain the observed differences between ldh isozymes in cl/cp ratios , tissue uptake , and extra-vascular distribution volumes by the ionic interaction of ldh 5 with these negative change sites which would retard the plasma-lymph transport and enhance the extravascular distribution volume and initial clearance of these cationic macromolecules .
C0022023
ionic
C0007447
cationic