in contrast to cyclazocine , which also was found to be approximately 15 times more potent agonist than morphine , naloxone had no demonstrable agonistic activity and naltrexone and the various naloxone and naltrexone derivatives had only insignificant agonistic activity with ed50/ke ratios ranging from 2,000 to about 120,000 .
C0027358
naloxone
C0027360
naltrexone