the authors propose that dysfunction of neuronal circuits interconnecting the orbitofrontal cortex , basal ganglia/limbic striatum , and thalamus serves a critical role in the pathogenesis of ocd and that obsessive-compulsive symptoms occur when an aberrant positive feedback loop develops in the reciprocally excitatory frontothalamic neuronal interchange , which is inadequately integrated or inhibited by the ventromedial ( limbic ) portions of the striatum ;
C0004781
basal ganglia
C0010097
striatum