administration to white rats of phenobarbital , benzonal and benzobamyl in a dose of 1/20 ld50 for 4 -- 14 days was accompanied by enhanced respiration of microsomes isolated from liver tissue , by acceleration of nad.h and nadp.h oxidation , by activation of amidopyrin and hexobarbital metabolism , by an increase in the hepatocyte content of p 450 and b5 .
C0736268
liver tissue
C0227525
hepatocyte