in particular it is suggested that the peptide bond of the substrate adjacent to that about to be cleaved , is bound in the cleft of the enzyme between the nh group of glycine-66 and the backbone c=o group of aspartic acid-158 , and provides a sensitive amplification mechanism through which the specificity of the enzyme for hydrophobic amino acids such as l-phenylalanine is relayed .
C0017890
glycine
C0002520
amino acids