to determine if long-term methotrexate-induced improvement of rheumatoid arthritis is sustained after the drug is discontinued , 10 unselected patients with responses to weekly oral methotrexate given for at least 36 months ( mean 40.1 ) were randomly assigned to receive methotrexate or identical-appearing placebo tablets for two months .
C0003873
rheumatoid
C0025677
methotrexate