the increased incidence of the infection rate during childhood , the low humoral and cell-mediated immune responses towards many bacterial and viral antigens and the presence of these specific immune deficiencies in a group of doubtful ms cases being at the first bout of the disease , led us to consider ms as a multi-specific immune deficiency disease , possibly having its origin in the genes controlling the immune response to these specific antigens .
C0009450
infection
C0012634
disease