when the isolated canine pancreas was perfused under the perfusate condition of acidosis ( ph 7.1 ) , ketoacidosis ( ph 7.1 and 20 mm 3-ohb ) or hyperosmolarity ( +60 mosm/kg with sucrose ) throughout the experiment , the glucagon concentrations produced by 2.8 mm glucose under the ketoacidotic and hyperosmolar conditions , were less than half of those obtained under the standard condition .
C0001122
acidosis
C0022638
ketoacidotic