addition of corticosteroid-binding globulin ( cbg ) in amounts sufficient to bind 50 % of the cortisol reduced the clearance ( 0.40 +/- .026 ) insignificantly , whereas human serum albumin ( hsa ) in amounts sufficient to bind 50 % of the cortisol reduced the clearance to 0.28 +/- 0.012 ( p less than 0.001 ) even though the association constant for albumin is approximately 1000-fold less .
C0304925
human serum albumin
C0001924
albumin