nonpyrogenic amounts of endotoxin ( 0.1 to 1 ng/kg ) , hardly detectable by conventional limulus amoebocyte lysate tests , could produce a fever of around 1 degree c when injected with a nonpyrogenic dose ( 6 x 10 ( 5 ) u/kg ) of recombinant human beta interferon ( ifn-beta ) in rabbits .
C2917415
recombinant
C0015980
ifn-beta