twenty-seven patients with osteosarcoma and measurable metastases were treated with low-dose methotrexate ( ldmtx ) ( 80 mg/m2 ) , followed by high-dose methotrexate ( hdmtx ) ( 7.5 g/m2 ) after disease progression in 14 patients .
C0029463
osteosarcoma
C0025677
methotrexate