homozygous mice , injected from birth with the relevant anti-delta antibody , made primary or secondary immune responses to intravenously injected trinitrophenyl ( tnp ) -brucella abortus , tnp-ficoll , and tnp-keyhole limpet hemocyanin , which did not differ significantly from those of control mice , despite the fact that igd+ cells were depleted and ig+ cells were markedly reduced in the spleens of treated mice .
C0301872
immune responses
C0020843
igd