the administration of mc to pb-treated rats induced a drastic decrease in the p-450pb-dependent oxidations of benzo ( a ) pyrene and 7-ethoxycoumarin , while the corresponding activities of p-450mc increased sharply , and these changes were much more rapid than the change of the amount of each form of cytochrome p-450 .
C0030012
decrease
C0010762
cytochrome p-450