o-toluidine hydrochloride and one of its metabolites , o-nitrosotoluene , were administered in the diet ( 0.028 mol/kg diet ) to 2 groups of 30 male f-344 rats for 72 weeks . o-nitrosotoluene induced significantly more tumors of the bladder ( 16/30 rats ) and liver ( 20/30 ) than did o-toluidine hydrochloride ( bladder , 4/30 ;
C0005695
tumors of the bladder
C0005682
bladder