several factors that influenced response to primary treatment with methotrexate , actinomycin d , and cyclophosphamide chemotherapy were determined : 1 ) clinicopathologic diagnosis of choriocarcinoma versus invasive mole ( 59 versus 100 % ) , 2 ) metastases to sites other than the lung and/or vagina ( 44 versus 74 % ) , 3 ) antecedent term gestation compared with hydatidiform mole or abortion ( 50 versus 75 % ) , and 4 ) presence of three or more high-risk factors ( 27 versus 74 % ) .
C0025677
methotrexate
C0020217
hydatidiform mole