these experiments demonstrated that : ( 1 ) an inverse relationship between t and b cell function and nk cell activity was observed early after gvh induction , ( 2 ) the severity of histopathological lesions and immunosuppression , as well as the degree of overall augmented nk cell activity , was determined by the dose and genotype of donor cells injected to induce gvh reactions , and ( 3 ) gvh-associated moderate-severe lesions occurred only in groups in which nk cell activity peaked early -- whereas when nk cell activity peaked later , either mild or no lesions were observed , suggesting that the early rapid increase of nk cell activity may be useful for predicting the severity of gvh pathogenesis .
C0007613
cell function
C0007634
the