using escherichia coli rna polymerase and the endogenous engaged rna polymerase i as specific probes to monitor respectively the physiologically inactive and active nucleolar chromatin template function , this paper reports that aflatoxin b1 , after metabolic activation either in vivo or in vitro , binds preferentially to the physiologically active regions of rat liver nucleolar chromatin , and that this binding specificity is largely lost after the removal of chromosomal proteins from the nucleoli .
C0035681
rna
C0035678
rna polymerase i