because these agents are detoxified largely by glutathione-dependent mechanisms , efflux of reduced glutathione and glutathione disulfide into bile and perfusate was measured , along with bile flow , excretion of endogenous bile acids , lactate dehydrogenase release and the bile/perfusate ratios of [ 14c ] sucrose ( a marker of junctional permeability ) and [ 3h ] polyethylene glycol-900 ( a substance concentrated in bile , presumably by a vesicular transport pathway ) .
C0017817
glutathione
C0061516
glutathione disulfide