these findings suggest that polyclonal highly tmp-smx-resistant shigella emerged by transfer of trimethoprim resistance genes from aerobic bowel flora to endemic shigella strains , that use of antimicrobials can lead to symptomatic shigellosis and thus the persistence of trimethoprim-resistant shigella , and that appropriate therapy of shigellosis on the reservation is now a major challenge .
C0041044
tmp-smx
C0041041
trimethoprim