both picenadol and codeine were significantly more effective than placebo in reducing pain intensity ( mean sum of pain intensity difference scores : picenadol 5.21 , codeine 5.19 , and placebo 2.82 ) and increasing total relief ( mean total pain relief : picenadol 10.21 , codeine 11.07 , and placebo 6.96 ) .
C0030193
pain
C0009214
codeine