the degree of heterogeneity in c57bl/6 mice was markedly higher than that in cba mice under the following conditions of immunization : immunization with tnp conjugated with bovine gamma-globulin or ovalbumin , interchange of these carrier proteins at the first and second injections , change of epitope density of the antigens , replacement of the hapten by dinitrophenyl group on the antigen for the secondary stimulation , and change of intervals of these injections from 15 days to five months .
C0003316
epitope
C0003320
antigen