salt and water retention may be an important factor in the blood pressure-raising effect of indomethacin during diuretic or propranolol therapy : in addition , prostaglandin synthesis may be important in counteracting increased alpha-adrenergic tone , which may limit the blood pressure-lowering effect of beta-adrenoreceptor-blockade .
C0033497
propranolol
C0020649
blood pressure-lowering