since novobiocin has been shown to inhibit rna polymerases ii- and iii-directed transcription of linear dnas by interfering with a step ( s ) in the initiation reaction , these data suggest that initiation of transcription of all classes of rna is inhibited by novobiocin by a mechanism independent of its effect on dna topoisomerase ii .
C0040649
transcription
C0012863
dna topoisomerase ii