estradiol administration or castration of male rats retarded manifestation of vitamin k deficient syndromes such as increases of pt and activated partial thromboplastin time ( aptt ) , decreases of plasma factor vii and prothrombin levels , and increases of plasma and liver descarboxyprothrombin ( pivka ) levels , and testosterone injection to the castrated rats restored these changes .
C0015502
factor vii
C0023884
liver