reproduction tests ( male and female fertility test on rats p.o . with 10 and 50 mg/kg ; teratogenicity test in midpregnancy on rats p.o . with 12.5 , 25 , 50 mg/kg , 15 , 50 , 150 mg/kg , and 15 , 45 , 135 mg/kg daily doses , i.v . with 3.13 , 6.25 and 12.5 mg/kg daily doses ; on rabbits p.o . with 6 , 12 and 18 mg/kg daily doses ; peri- and postnatal studies in late pregnancy on rats p.o . with 15 , 45 and 135 mg/kg i.v . with 4.13 , 6.25 , and 12.5 mg/kg daily doses ) were carried out to study harmful effects in various early phases of life .
C0679560
reproduction tests
C0022885
test