1 intravenous injections of urotensin i regularly caused a long-lasting , dose-related , lowering of blood pressure and an increase in heart rate in conscious rats , or a reduction in perfusion pressure in the isolated hind limb of the rat.2 after subcutaneous administration , the hypotensive effect of urotensin i was greater in extent and in duration ( > 24 hours ) .3 anaesthesia with ether , chloralose , pentobarbitone and thiobarbitone caused a decrease in blood pressure and only slightly diminished the hypotensive effect of urotensin.4 mecamylamine , hexamethonium , atropine , phenoxybenzamine , propranolol and diphenhydramine did not alter the effect of urotensin in conscious rats or in the isolated hind limb , although the effects of the respective agonists , i.e . nicotine , acetylcholine , noradrenaline , isoprenaline and histamine were inhibited.5 in conscious rats , pressor effects of adrenaline , noradrenaline , nicotine and angiotensin ii , and depressor effects of acetylcholine and bradykinin , were decreased or inhibited , whereas the hypotensive effect of phenoxybenzamine was potentiated by previous administration of urotensin i .
C0020649
lowering
C0033497
propranolol