the present paper describes 3 out of a total of 9 siblings , aged 9 , 17 , and 18 , with the following symptoms : gargoyle-like facial features , clouding of the cornea in both eyes , dysostosis multiplex , slightly impaired intelligence , hepatosplenomegaly , umbilical hernia , and increased secretion of mucopolysaccharides in the urine , in particular dermatan and heparan sulfate .
C0017973
mucopolysaccharides
C0019143
heparan sulfate