antagonism followed by recovery.4 when different doses of the same antidepressant were applied , it was found that the drug-interaction patterns were related to the dose of antidepressant applied , a lower dose causing potentiation , and a higher dose antagonism of the response.5 both potentiation and antagonism of depressant responses to noradrenaline could be observed.6 both excitatory and depressant responses to 5-hydroxytryptamine were modified by imipramine and desipramine : a smaller dose of the antidepressant potentiated , and a higher dose antagonized the responses.7 excitatory responses to glutamate were not affected by imipramine and desipramine .
C0003289
antidepressant
C0020934
imipramine