impairment in pancreatic production of insulin , a cardinal feature of noninsulin dependent diabetes mellitus ( niddm ) , was quantified and the kinetics of insulin secretion characterized in six obese individuals with niddm before and after weight loss ( 18.0 +/- 3.0 kg , mean +/- sem ) using a validated mathematical model that employs c-peptide as a marker of the in vivo rate of insulin secretion .
C0030274
pancreatic
C0011849
niddm