the reduced pituitary responsiveness to lhrh in t-plus m-treated rats may be a consequence of either a direct pituitary effect of opiates in conjunction with t or augmented action of hypothalamic neurohumoral agents which may inhibit lh release on their own or antagonize the lh-releasing action of lhrh at the level of pituitary gonadotrophs .
C0020663
hypothalamic
C0023610
lhrh