neomycin , an aminoglycoside antibiotic that interacts with polyphosphoinositides , inhibited the breakdown of both phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate , with the latter process being appreciably more sensitive to the drug .
C0071655
polyphosphoinositides
C0031621
phosphatidylinositol