in an attempt to induce significant , sustained reductions in o2 affinity of hemoglobin by primary dpg stimulation , six normal humans were given a diphosphonate ( etidronate disodium [ didronel ] 20 mg/kg/day p.o . ) followed by infusion of 10 % fructose ( 0.5 l/hr for 3 hours ) with added phosphate ( 0.28 mmol/kg/hr ) and , subsequently , fructose-phosphate by itself .
C0012544
diphosphonate
C0086268
etidronate