it is concluded that in cardiac hypertrophy associated with different models of hypertension the decreased inotropic responsiveness to isoproterenol is associated with different biochemical defects in the beta-adrenergic receptor response coupling pathway , and that reversal in function occurs only when there is no apparent change in the catalytic subunit of the adenylate cyclase complex .
C0020538
hypertension
C0001643
beta-adrenergic receptor