bis ( 5-amidino-2-benzimidazolyl ) methane is shown to block acute synovitis , to retard and reduce granuloma formation in spleen and liver , to decrease neutrophilic leukocytosis , and to diminish hemopoietic hyperplasia in the bone , and thus also to mitigate the distinctive osteoclastic and chondroclastic events .
C1739148
acute
C0262950
bone