it is concluded that the observed diminished co sensitivity of microsomal benzo [ a ] pyrene hydroxylase in 3-methylcholanthrene- or 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats results from alterations in the composition and/or structural organization of the microenvironment of cytochrome p-448 in the endoplasmic reticulum in response to the inducing action of polycyclic aromatic hydrocarbons and related agents , and is not related to changes in the heme protein p-448 per se .
C0010798
cytochrome
C0018974
heme protein