oxidative metabolism of the polyfunctional alkylating agent n , n ' , n '' -triethylenethiophosphoramide ( thio-tepa ) was studied in isolated rat liver microsomes and purified , reconstituted cytochrome p-450 ( p-450 ) enzyme systems in order to elucidate the pathways of drug oxidation and to identify the possible contributions of individual p-450 enzymes to the bioactivation of this chemotherapeutic agent .
C0039871
triethylenethiophosphoramide
C0039533
tepa