by immunofluorescence and interference reflection microscopy ( irm ) we found that f-actin and a group of cytoskeletal proteins involved in microfilament-membrane interaction , including vinculin , alpha-actinin , fimbrin and talin , are specifically organized in discrete dot-like structures corresponding to cell-substratum contact sites in both monocytes and monocyte-derived cells such as macrophages and osteoclasts .
C1180307
f-actin
C0007634
cell