1 the effect of the ether anaesthesia on the plasma half-life of n- ( 2 hydroxy ethyl ) 2-phenyl ethyl carbamate has been studied in rats.2 the plasma half-life of the carbamate was considerably shorter in animals anaesthetized with ether prior to drug administration than in control rats.3 the longer plasma half-life of the carbamate in control animals was shown to be due to enterohepatic circulation.4 inhibition of this phenomenon by ether was responsible for the shorter plasma half-life of the carbamate in animals anaesthetized with this agent before drug administration.5 the possible mechanisms by which the ether-induced effect is brought about are discussed .
C0041964
ethyl carbamate
C0006948
carbamate