bethanechol ( 10 ( -4 ) m , a ca2+-mediated secretagogue ) caused an increase in isc , which was enhanced 4-20 fold when the tissue was pretreated with prostaglandin e2 ( 10 ( -7 ) -10 ( -6 ) m ) , vasoactive intestinal polypeptide ( 5 x 10 ( -9 ) -10 ( -8 ) m ) ( cyclic amp-mediated secretagogues ) , or 8-bromocyclic amp ( 5 x 10 ( -4 ) -2 x 10 ( -3 ) m ) .
C0001455
cyclic amp
C0000661
8-bromocyclic amp