2-hydroxy-saclofen ( 2-oh-s ) , a sulphonic analogue of baclofen , slightly increased the twitch height and reversibly antagonised the gaba- and baclofen-induced depression of twitch contractions in the guinea pig vas deferens and isolated ileum , causing a parallel dextral shift in the baclofen dose-response curve in a competitive manner ( pa2 = 5.0 ) in the latter tissue .
C0016904
gaba
C0004609
baclofen