we have examined the influence of simvastatin , a competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme a reductase on plasma concentrations of lipids and lipoproteins , the rates of cholesterol biosynthesis and degradation of 125i-labelled ldl by freshly isolated mononuclear leucocytes and the 24 h urinary excretion of mevalonic acid in patients with heterozygous familial hypercholesterolaemia .
C0023779
lipids
C0023820
lipoproteins