in order to investigate the possibility of a defect at the nuclear receptor for t3 , we examined : 1 ) equilibrium binding of [ 125i ] t3 ( 64 analyses ) to the nuclei of intact cultured fibroblasts from 12 patients with both sporadic and familial generalized or selective pituitary resistance , 17 normal subjects , and two apparently normal siblings from affected families ;
C0206588
nuclear receptor
C0007610
nuclei