to examine the effect of the major histocompatibility locus ( hla ) and the duration of insulin-dependent diabetes ( iddm ) on immune responses to insulin we assayed insulin induced proliferation of blood mononuclear cells and measured insulin antibodies in 66 patients with newly diagnosed and in 56 patients with longstanding iddm matched for the age at onset ( less than or equal to 15 years ) .
C0021641
insulin
C0011854
iddm