functional studies that distinguish free from actin-bound gelsolin based on the ability of the former to sever actin filaments reveal that the binding of actin monomers to gelsolin is highly cooperative and can be prevented by prior incubation of actin with vitamin d-binding protein ( dbp ) , even though the apparent affinity of gelsolin for actin is 50-fold greater than that of dbp .
C0025979
actin filaments
C0001271
actin