the immunoglobulin fraction of a polyclonal anti-insulin receptor antibody ( b-10 ) derived from a patient with severe insulin resistance and acanthosis nigricans was tested for its ability to activate the protein kinase activity of the insulin receptor and to mimic insulin action in chinese hamster ovary cells expressing either wild type or kinase-deficient human insulin receptors .
C0031727
kinase
C1448132
human insulin receptors