the induction of tnf-alpha was to spherules and not to contaminating lipopolysaccharide ( endotoxin ) , as evidenced by the finding that polymyxin b , a reagent that blocks the tnf-alpha-inducing component of lipopolysaccharide , did not negate the production of tnf-alpha in response to spherules , whereas pretreatment of spherules with hyperimmune goat antiserum to spherulin neutralized the induction of tnf-alpha by these cells .
C0014264
endotoxin
C0023810
lipopolysaccharide