the membrane sites for synapsin involve protein ( s ) and are likely to have physiological relevance since the binding of 125i-labeled synapsin is abolished by digestion with chymotrypsin , is displaced by unlabeled synapsin , is of high affinity ( kd = 10 nm ) , and has a capacity ( 42 pmol/mg membrane protein ) that is comparable to the amount of synapsin in brain , optimal binding occurs at physiological ph ( 6.8-7.2 ) and salt concentrations ( 50 mm ) , and synapsin binding to membranes is inhibited by phosphorylation with ca2+/calmodulin-dependent protein kinase .
C0006104
brain
C0086045
concentrations