furthermore , the nucleolar segregation phenomenon , already described in experimental doxorubicin myocardiopathy , was not observed in the myocardial samples taken 1 and 3 h after dnr or 4dd injection : this fact may be interpreted , without excluding a possible dna-mediated toxic mechanism , as the result of different kinetic behaviour of dnr and 4dd compared to doxorubicin .
C0011015
dnr
C0013089
doxorubicin