these findings are important because 1 ) there is no known physiologic regulator that actively down-regulates class ii molecules that are present in and/or on cells , 2 ) levels of mrna derived from a very limited number of genes are known to be altered by 1,25 ( oh ) 2d3 , and 3 ) they support the contention that 1,25 ( oh ) 2d3 may alter the differentiation state of these cells and the activity of the normal counterpart of these cells in an immune response .
C0007589
the differentiation
C0007634
normal