after discussion of the role of prostanoids as mediators of inflammation , evidence is given that prostanoids are present in the joints of patients with rheumatoid arthritis , that these substances are capable of causing joint damage in vitro and in vivo , and that drugs which are able to arrest the progress of the arthritic condition or bring symptomatic relief possess the ability to inhibit prostanoid synthesis in vivo and in vitro .
C0003873
rheumatoid arthritis
C0022417
joint