the first study , during which combined chemotherapy with cyclophosphamide , methotrexate , 5-fluorouracil , vincristine , and prednisone ( cmfvp ) administered for 1 year was compared with single agent therapy with melphalan ( l-pam ) for 2 years , was activated in 1975 and closed in 1978 .
C0025677
methotrexate
C0055987
cmfvp