the disposition of zomepirac ( z ) and its acyl glucuronide metabolite were studied in rabbits and guinea pigs to determine if hydrolysis of zomepirac glucuronide ( zg ) by tissue esterases occurs in vivo and what effect inhibition of esterases would have on exposure to zg and subsequent covalent binding to plasma proteins .
C0020291
hydrolysis
C0014894
esterases