it is suggested that isopycnic centrifugation in metrizamide is a simple method for determining the effects of salts ( and other small molecules ) on the hydration of nucleic acids under conditions of high ratios of salt to dna ( > 5 x 10 ( 3 ) moles/mole ) while high ( 0.999 ) water activity is maintained .
C0028606
nucleic acids
C0012854
dna