the phorbol ester tumor promoter 12-o-tetradecanoylphorbol-13-acetate ( tpa ) showed a significant dose-related inhibitory effect on ep production and dome formation in the renal carcinoma cell cultures , suggesting an important role of protein kinase c , the only known receptor for tpa , in inhibiting the expression of differentiated phenotypes in the renal carcinoma cells .
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differentiated
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cells