incubation of s100a with calcium and kcl proved that calcium binding to the putative calcium-binding sites ( site i alpha , i beta ) triggers a time- and temperature-dependent conformational change in the protein structure which decreases the antagonistic effect of kcl on calcium binding to sites ii alpha and ii beta and provokes subunit exchanges between protein dimers and the emergence of s100 alpha alpha and s100b ( beta beta ) proteins .
C1516144
calcium binding
C1419781
s100 alpha