results suggested ( 1 ) that substantial rem sleep reduction has antidepressant activity , and ( 2 ) since imipramine and other drug antidepressants reduce rem sleep much more so than nonantidepressant drugs , that an antidepressant `` '' mechanism '' '' of drugs resides in their capacity to substantially reduce rem sleep .
C0020934
imipramine
C0003289
antidepressant