antrum-bulb resection significantly reduced basal acid secretion and maximal acid responses to the humoral stimuli ( about 45 % reduction ) but did not significantly change the loss of gastric contents to the intestine or the sensitivity to the humoral stimuli ( median ed50 of pentagastrin increased from 5.2 to 6.7 mug/h in 14 patients , and median ed50 of histalog increased from 16.0 to 20.8 mg/h in 12 patients ) , suggesting that the intact antrum-bulb region of the ulcer patient is controlling the capacity to secrete acid , and indicating that antrum-bulb gastrin is an important trophic factor for the parietal cells in man .
C0030859
pentagastrin
C0017151
gastrin