the chronic hypervolaemia in these subjects leads to a release of the natriuretic factor which depresses the na ( + ) -k ( + ) -atpase in the cell membranes and which is responsible for an increase in sodium ( and calcium ) content of the vascular smooth muscle cells , diminishing their compliance and thus raising the vascular resistance together with the thickening of the vascular wall of the originally hyperperfused vessels .
C0007603
the
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cells