1 several compounds were tested for their ability to inhibit prostaglandin metabolism in guinea-pig lungs.2 in isolated perfused lungs polyphoretin phosphate ( ppp ) inhibited prostaglandin metabolism being active at concentrations greater than 100 ng/ml and having an id ( 50 ) of 2.15 mug/ml against prostaglandin e ( 2 ) metabolism and 1.55 mug/ml against prostaglandin f ( 2alpha ) metabolism.3 at these doses no antagonism of the actions of prostaglandins was seen.4 diphloretin phosphate ( dpp ) was more active on a weight for weight basis and inhibition of inactivation of prostaglandins was seen at concentrations greater than 10 ng/ml , the id ( 50 ) being 0.54 mug/ml against both prostaglandins e ( 2 ) and f ( 2alpha ) .5 at concentrations greater than 5 mug/ml dpp antagonized the actions of prostaglandin f ( 2alpha ) .6 the sulphydryl-binders n-ethyl maleimide ( nem ) and sodium p-chloromercuriphenyl sulphonate ( pcms ) also inhibited prostaglandin inactivation by guinea-pig isolated lungs.7 all four compounds inhibited prostaglandin metabolism by a crude enzyme preparation from guinea-pig lungs .
C0033561
prostaglandin f
C0033554
prostaglandin