pulse-chase experiments to analyze compartmentalization of newly synthesized collagen showed that the decrease in collagen synthesis was confined to the soluble pool of procollagen in the medium , while extracellular matrix associated collagen was not changed , indicating that a larger proportion of newly synthesized collagen was deposited into the matrix in ifn-gamma exposed fibroblasts ( 34.2 vs. 25.3 % ) .
C0033235
procollagen
C0009325
collagen