we have previously shown that the steroid hormone-mediated transcriptional activation of the chicken vitellogenin ii gene ( vtgii ) in the liver is accompanied by a series of chromatin structural changes , including the formation of two sets of 5'-proximal nuclease-hypersensitive sites and the demethylation of a single 5'-flanking mspi site which lies within a region of dna that recently has been shown by jost and co-workers to specifically bind the estrogen receptor complex in vitro .
C0162493
transcriptional
C0034804
estrogen