measurements of functional parameters in closed-chest rats revealed that i.v . administration of ribose alone for 24 h ( 200 mg/kg/h ) had no hemodynamic or vasoactive influence , whereas verapamil and metoprolol ( i.v . infusion of 2 mg/kg/h each for 24 h ) induced negative chronotropic and negative inotropic effects .
C0025859
metoprolol
C1372752
negative chronotropic