metabolism of warfarin to 4'- , 6- , 7- , 8- , and 10-hydroxywarfarin and dehydrowarfarin by highly purified rat liver cytochrome p-450 ( p-450 ) isozymes reconstituted with nadph-cytochrome p-450 reductase and by hepatic microsomes from variously pretreated rats was used to probe functional consequences of p-450 isozyme/isozyme interactions and of the effect of microsomal reductase concentrations .
C0025519
metabolism
C0010762
cytochrome p-450