twelve asthmatic patients ( fev1 , 81 +/- 4 % predicted ) , requiring only occasional inhaled beta-agonists as their sole therapy , were given a 14-day treatment with high dose inhaled salbutamol ( hds ) , 4,000 micrograms daily , low dose inhaled salbutamol ( lds ) , 800 micrograms daily , or placebo ( pi ) by metered-dose inhaler in a double-blind , randomized crossover design .
C0004096
asthmatic
C0001927
salbutamol