to study the effects of skf-525a , an inhibitor of cytochrome p-450 , and of sodium phenobarbital ( pb ) , a drug-metabolizing enzyme inducer , on the teratogenicity of thiabendazole ( tbz ) , pregnant mice were given ip either a single dose of 40 mg skf-525a/kg 1 hr before oral dosing with 250 or 500 mg tbz/kg or a dose of 75 mg pb/kg/day on three consecutive days before oral administration of a dose of 500 or 1000 mg tbz/kg .
C0282303
sodium phenobarbital
C0031412
pb