examination of the accumulation kinetics of these reduced folates showed that after i.v . administration of 20 mg d , l-leucovorin to a healthy volunteer , fh4 and , to a lesser extent , ch2fh4 accumulated to maximal levels very early ( less than 15 min ) , with a subsequent depletion that had a half-life of approximately 30 min .
C0022702
kinetics
C0018517
half-life