data herewith reported on three sibs with figd supported the following conclusions : 1 ) figd is due to insufficient hypothalamic luteinizing hormone-releasing hormone ( lrh ) secretion , 2 ) the sensitivity of leydig cells to hcg is normal , 3 ) lrh treatment may be helpful in these patients , 4 ) an associated hypothalamic-pituitary-prolactin ( prl ) dysfunction may also be present , and 5 ) figd and the kallmann syndrome are different entities having a similar pathophysiology but different cause and overall clinical picture .
C0020663
hypothalamic
C0023610
lrh