guanethidine at 5-25 mm concentrations was found to induce up to 79 % inhibition of adp-stimulated ( state iii ) oxygen consumption in isolated rat heart , brain or liver mitochondria , when the added substrate was glutamate or succinate , but the inhibition was considerably lower ( 24 % or less ) when respiration was supported by ascorbate plus tetramethylphenylenediamine ( tmpd ) .
C0086045
concentrations
C0006104
brain