two possible mechanisms of interaction are discussed : ( 1 ) direct interaction of oligonucleotides with the inner part of protein aggregate through the central hole of the particle due to the fluctuational opening of the v-helices ( 2 ) binding of oligonucleotides on the end surfaces of hpa followed by their redistribution along the particle due to the end-to-end association and disruption of particles .
C0033684
protein
C0025252
surfaces