based on ( 1 ) the histogenetic-embryologic classification of germ cell tumors and the concept of yolk sac tumor ( or endodermal sinus tumor ) , ( 2 ) the available clinical and experimental observations , and ( 3 ) the immunofluorescent localization of afp in the endodermal sinus tumor of the human testis , it is concluded that afp synthesis in these neoplasms is explained by the fact that they contain yolk sac endoderm , which produce afp analogous with the physiological afp synthesis by the fetal yolk sac in early embryogenesis .
C0205851
the
C0027651
neoplasms