that is , while increased adrenergic input to the heart may initially enable the failing myocardium to function adequately for a period of months to years , continued excessive adrenergic stimulation of the heart through both local neural and circulating catecholamines may lead to frank myopathic effects on the heart , with resultant worsening of left ventricular function and the development of intractable congestive heart failure .
C0027061
myocardium
C0018787
heart