described by lloyd and dennis in 1963 , cowden 's disease is a familial affection in which are found associated lesions of the buccopharyngeal mucosa ( papillomatosis , papules , scrotal tongue ) , various types of skin lesions ( verruciform keratotic papules , papilloma , lipoma , angioma , etc ... ) , visceral manifestations usually related to lesions in the thyroid , breasts , or digestive tract ( hamartoma or malignant tumors ) , and skeletal dysmorphism .
C0018553
cowden 's disease
C0018552
hamartoma