the histological findings and the nature of the skin reactions suggest that a positive outcome of the test is indicative of an immediate , type i hypersensitivity towards components of the oral secretion of fleas and that this hypersensitivity is mediated by reaginic antibody which to some extent is produced by plasma cells located in skin areas where flea saliva is deposited .
C0020523
type i hypersensitivity
C0020517
hypersensitivity