whereas pure monolayers of either the familial hypercholesterolemia cells ( lacking cell surface ldl receptors ) or the acid lipase-deficient cells ( lacking cholesteryl ester hydrolase activity ) responded poorly to ldl , the mixed monolayers developed lipoprotein responsiveness as measured by an enhancement of both ldl-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and ldl-mediated stimulation of cholesteryl ester formation .
C0699040
cell surface
C0007634
cells