analysis of 213 cases from the literature shows the following features : -- males and females are equally affected , with a predominance after the age of 50. -- the onset is characterized by constitutional symptoms ( 75 % ) and fever ( 65 % ) , sometimes following exposure to drugs. -- the signs are generalized adenopathy ( 91 % ) , splenomegaly ( 66 % ) , hepatomeagly ( 65 % ) , and skin rash ( 46 ) . -- polyclonal hypergammaglobulinemia ( 76 % ) is found , together with anemia ( 78 % ) which is often autoimmune in origin ( 58 % ) . -- the course is often unfavourable and the mortality is over 55 % , largely due to opportunistic infections and/or development of immunoblastic lymphoma .
C0497156
adenopathy
C0079746
immunoblastic lymphoma