the distribution , metabolism , and pharmacokinetics of physostigmine ( phy ) and the time course of butyrylcholinesterase ( buche ) in plasma and cholinesterase ( che ) activity in brain and muscle and their relationship to phy concentration were described after oral administration of 3h-phy ( 650 micrograms kg-1 ) to rats .
C0006104
brain
C0086045
concentration