to identify the nucleotide changes that occur in drug-induced thymidine kinase ( tk ) mutants of herpes simplex virus type 2 ( hsv-2 ) , we compared the nucleotide sequences of the tk genes of two mutant hsv-2 clones isolated from a patient who had been treated with acyclovir [ 9- ( 2-hydroxyethoxymethyl ) guanine ; acv ] with the nucleotide sequence of the parental tk+ hsv-2 ( 8703 ) strain isolated from the same patient .
C0001367
acyclovir
C0018321
guanine