although xid/y mice fail to make a detectable primary antibody response to a variety of antigens such as type iii pneumococcal capsular polysaccharide ( siii ) , 2,4 , 6-trinitrophenyl ( tnp ) -ficoll , pneumococcal c carbohydrate , group a streptococcal vaccine and several kinds of related antigenic determinants such as phosphorylcholine ( pc ) and n-acetyl-glucosaminyl ( glcnac ) , even when the latter are coupled to hemocyanin ( hy ) , they do show : ( a ) an antigen-dependent development of splenic b cells which can act as successful , productive fusion partners for sp2 cells giving hybridomas making monoclonal anti-siii , anti-pc , anti-glcnac , anti-tnp , etc. , and ( b ) an antigen-dependent appearance of antigen-binding plasmablasts in their spleens .
C1519473
development
C0037993
spleens