a direct correlation exists between the level of histone h4 hyperacetylation induced by sodium butyrate and the extent to which nucleosomes lose their compact shape and become elongated ( 62.0 % of the particles have a length/width ratio over 1.6 ; overall mean in the length/width ratio = 1.83 +/- 0.48 ) when bound to electron microscope specimen grids at low ionic strength ( 1mm edta , 10mm tris , ph 8.0 ) .
C0019648
histone h4
C0028623
nucleosomes