when purified leu-1+ and leu-1- b lymphocytes were transformed into immunoglobulin-secreting cells by infection with epstein-barr virus and the culture fluids were tested for reactivity with self-antigens , at least two important autoantibodies , antibody to the fc fragment of human immunoglobulin g ( rheumatoid factor ) and antibody to single-stranded dna , were found to be made exclusively by leu-1+ b cells .
C0004358
autoantibodies
C0035448
rheumatoid factor