in the process of evaluating roles for purified preparations of lactoferrin , transferrin and acidic isoferritins in the regulation of myelopoiesis , it was found that : ( 1 ) values reported for lactoferrin in the serum and plasma of normal donors are in most cases an over-estimation , ( 2 ) lactoferrin suppresses the production/release of granulocyte-macrophage colony stimulatory factors ( gm-csf ) from monocytes in the absence of t-lymphocytes and also suppresses the production/release of acidic isoferritin-inhibitory activity from monocytes , ( 3 ) lactoferrin , transferrin and acidic isoferritins act on their specific target cells which express ia-like antigens , ( 4 ) lactoferrin and transferrin act in vivo to suppress rebound myelopoiesis in mice recovering from sublethal dosages of cytoxan , with preliminary observations suggesting that lactoferrin has a greater apparent effect on the bone marrow and transferrin has a greater apparent effect on the spleen , ( 5 ) active lactoferrin derives from fc receptor positive subpopulations of pmn from patients with cml as well as from normal donors , but the percentage of fc receptor containing pmn is lower in cml , as is the amount of active lactoferrin found in their pmn , and ( 6 ) lactoferrin , transferrin and acidic isoferritins suppress the colony formation of u937 clonogenic cells , with lactoferrin and transferrin decreasing the release of growth factors from u937 cells which are needed to stimulate u937 colony formation , and lactoferrin and acidic isoferritins suppress the colony formation of wehi-3 cells , with lactoferrin decreasing the release of growth factors from wehi-3 cells which are needed to stimulate wehi-3 colony formation .
C0018183
colony
C0005953
bone marrow