our results of in vivo pharmacology and in vitro [ 3h ] prazosin binding in canine narcolepsy now clearly implicate the low affinity [ 3h ] prazosin binding site ( alpha 1b ) in canine narcolepsy : ( 1 ) prazosin , an alpha 1 antagonist with similar affinity for both subtypes , was much more potent in increasing cataplexy than wb4101 , a compound with more affinity for the alpha 1a receptor .
C0027404
narcolepsy
C0007384
cataplexy