a number of examples demonstrate the effectiveness of rational strategies of strain development , e. g. , the removal of non-specific repressions of secondary metabolism by environmental factors , the excessive production of precursors due to altered control of intermediary metabolism , the increased resistance of producer organism against the autotoxicity of some idiolites , the deletion of alternative pathways of the primary and secondary metabolism , manipulations concerning the product spectrum , the deletion of feedback mechanisms , and elimination of degradating pathways in the secondary metabolism etc .
C0025519
intermediary metabolism
C0221102
elimination