the time course of heart rate action correlated ( 8.3 and 12.5 % decreases with 0.3 and 0.6 mg iv , respectively ; 6.5 and 9.5 % decreases with 0.3 and 0.6 mg po , respectively ) with the time course of beta-methyldigoxin and its metabolite digoxin in shallower pharmacokinetic compartments ( peaks at approximately 80 min intravenously and 135 min orally ) , and significant effects had disappeared by 10 hr after drug administration .
C0025132
beta-methyldigoxin
C0012265
digoxin