when exogenous noradrenaline was continuously infused into catecholamine-depleted pithed rats , xamoterol showed dose-related positive chronotropic effects with noradrenaline at 0.5 micrograms/ ( kg min ) ( hr : 235 +/- 4 beats/min ) , virtually no effects at 1.5 micrograms/ ( kg min ) ( hr : 297 +/- 11 beats/min ) and dose-related negative chronotropic effects at 5 micrograms/ ( kg min ) ( hr : 330 +/- 5 beats/min ) .
C1372804
positive
C0028351
noradrenaline