although a reduction in blood ethanol concentration has been proposed to mediate the ethanol antagonist activity of naloxone observed in clinical and experimental situations , an increase in this variable as well as in brain ethanol concentration has been found in rats treated with naloxone ( 0.5 and 2.0 mg/kg , i.p . ) ten min after intragastric administration of ethanol ( 1 and 2 g/kg ) .
C0006104
brain
C0086045
concentration