analysis of the subnuclear distribution of large t antigens in wild-type and in mutant-transformed cells kept at permissive or at nonpermissive growth temperature , respectively , revealed an important biological difference between the mutant t antigens in n- and a-type transformants : whereas the subnuclear distribution of wild-type large t in fr ( wt648 ) cells remained unchanged at both growth temperatures , mutant large t in fr ( tsa58 ) a cells ( n-type transformant ) already 1 day after the shift to the nonpermissive growth temperature no longer stably associated with nuclear substructures , notably the cellular chromatin .
C0007634
cellular
C0008546
chromatin