it is shown , that the presence of a thick network of neural fibers with positive response to acetylcholinesterase ( ace ) in the biopsy specimens of the large intestine and positive , or sharply positive response to ace in the lamina propria and lamina muscularis of the mucosal layer is a precise morphologic marker of the hirschsprung 's disease .
C1179187
lamina propria
C0225357
lamina muscularis