in a prospective study , the addition of dipivefrin hydrochloride 0.1 % twice daily to one eye of 32 patients with early primary open-angle glaucoma or ocular hypertension , maintained on a bilateral beta 1- , beta 2-blocker twice daily , resulted in a significant decrease of mean intraocular pressure ( iop ) from 22.7 +/- 3.9 to 20.2 +/- 3.4 mmhg at 1 week ( p = 0.0001 ) and to 21.0 +/- 3.8 mmhg at 12 weeks ( p less than 0.02 ) in the dipivefrin-treated eyes .
C0339573
primary open-angle glaucoma
C0015392
eyes