although the antibacterial activity of desacetylcefotaxime ( des-ctx ) , the principal metabolite of cefotaxime ( ctx ) , is eightfold lower than cefotaxime , the metabolite inhibits many b-lactamase-producing enterobacteriaceae and unusual pseudomonas species resistant to agents such as cefamandole , cefoxitin , and cefoperazone . des-ctx is more stable than ctx to attack by beta-lactamases of some species such as bacteroides fragilis , proteus vulgaris , and the k-1 enzyme of enterobacter-klebsiella . des-ctx acts synergistically with ctx against many enterobacteriaceae and streptococcus faecalis .
C0007541
cefamandole
C0007552
cefoperazone