increased excretion of gamma-glutamyl transferase , alanine aminopeptidase and n-acetyl-beta-d-glucosaminidase , used clinically as markers for tubule toxicity of aminoglycosides , was maximal when gentamicin was administered to rats at 2 p.m. and was minimal when injected at 8 p.m .
C0002556
aminoglycosides
C0017436
gentamicin