at the time of maximum reduction of rem sleep , the concentration of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate ( mopegso4 ) , a final product of norepinephrine metabolism in the brain , was found increased in the whole brains of rats suggesting that the selected doses of the drugs were sufficient to produce effective central alpha-adrenergic receptor blockade .
C0086045
concentration
C0006104
brain