the purpose of this investigation was to determine the relative contribution of diazepam and its active metabolites ( desmethyldiazepam , oxazepam and temazepam ) to the hypnotic activity of this benzodiazepine drug and to assess the role of rate of drug administration as a determinant of the relative concentrations of diazepam and its active metabolites in serum and in the central nervous system at the onset of a predefined pharmacologic endpoint .
C0029997
oxazepam
C0012010
diazepam