the question whether initial antihypertensive treatment with a beta-blocker prevents hypertensive complications better than initial treatment with a non-betablocker , mainly diuretic based treatment , has been studied in recent large-scale studies like the medical research council ( mrc ) trial , the international prospective primary prevention study in hypertension ( ipppsh ) , the heart attack primary prevention in hypertension ( happhy ) study and the metoprolol atherosclerosis prevention in hypertensives ( maphy ) study .
C0027051
heart attack
C0025859
metoprolol