studies employing pyrazinamide , which have included the measurements of clearances of pyrazinamide and pyrazinoate , as well as of ticrynafen itself and its principal metabolite , have lent support to the hypothesis that ticrynafen inhibits the tubular reabsorption of both filtered and secreted urate by nephrons of the human kidney .
C0027713
nephrons
C0022646
kidney