modification of proinsulin in the connecting peptide region near the a-chain of insulin to form split ( 65-66 ) hpi , des- ( 57-65 ) hpi , des- ( 64,65 ) hpi , or des- ( 33-56 ) hpi resulted in an increase in affinity for receptor binding ranging from 11 to 27-fold over that of intact hpi .
C0006558
connecting peptide
C0086418
hpi