because circulating pla2 had been shown experimentally to cause profound systemic hypotension and degradation of pulmonary surfactant , this suggests a mechanistic relationship between the massive release of pla2 into the systemic circulation during the course of gram-negative septicemia , and the resultant hypotension and respiratory distress syndrome associated with gram-negative septic shock .
C0031667
pla2
C0031672
a