the gene encoding the large-t protein of polyoma virus ( plt ) , the e1a genes of adenoviruses , the viral myc gene ( v-myc ) or rearranged forms of the cellular c-myc gene confer on rat embryo fibroblast ( ref ) cells in primary culture a series of new properties ( 'immortality ' , reduced serum requirement and sensitivity to transformation by viral and activated cellular oncogenes ) but do not induce the appearance of transformed foci .
C0042736
protein
C0017376
viral