based on the distribution of 125i-insulin between the cell surface and the cell interior , it was found that insulin rapidly binds ( t 1/2 = 0.4 min ) to surface receptors at 37 degrees c , and after an initial lag period of about 1 min , accumulates intracellularly until steady state is reached ( t 1/2 = 3.5 min ) .
C0699040
cell surface
C0007634
cell