release of acth from pituitary fragments incubated in vitro was stimulated in a dose-related manner by caffeine ( 0.01-10 mmol/l ) , and the responses to hypothalamic extract and sub-maximal concentrations of corticotrophin-releasing factor ( crf-41 ) or arginine vasopressin ( avp ) , but not camp , were significantly enhanced by 10 mmol caffeine/l .
C0020663
hypothalamic
C0010132
crf-41