1 the effects of prostaglandin ( pge ( 1 ) ) , following local administration during different phases of developing sponge-induced granulomata , were studied in normal and essential fatty acid deficient ( efad ) rats.2 in normal rats , a single dose of 1 mug pge ( 1 ) on implantation ( day 1 ) increased exudate production without altering total leucocyte counts after 6 h and stimulated granulomatous tissue formation after 8 days.3 repeated daily administration of the same dose of pge ( 1 ) on days 1 to 3 had no effect , while administration on days 4 to 7 ( i.e . when tissue growth is already in progress ) inhibited granuloma formation.4 in efad rats , which are known to produce only very small amounts of endogenous prostaglandins , acute ( 6 h ) exudate formation was unaffected by 0.05 mug pge ( 1 ) .
C0033554
prostaglandins
C0033559
pge