treatment of pregnant rats with antiestradiol ( a-e2 ) serum twice a day , starting at 2100 hours on day 19 , sharply increased circulating total estradiol ( e2 ) above control values and drastically reduced the biologically active e2 unbound ( e2u ) to a-e2 in plasma and uterine tissue .
C0229671
serum
C0032105
plasma