in conscious instrumented normotensive rats and dogs , intravenous and oral administration of bw a575c causes a dose-dependent rightward displacement of the pressor dose-response curve to angiotensin i ( dose ratio of 29.5 and 16.1 in rats and dogs , respectively , at 1.0 mg/kg i.v . ) and the tachycardia dose-response curve to isoprenaline ( dose ratio of 3.1 and 8.0 in rats and dogs , respectively , at 1.0 mg/kg i.v . ) .
C0039231
tachycardia
C0022245
isoprenaline