( ii ) the initial association of icp8 with the crude nuclear fraction was detergent sensitive but dnase resistant , and , thus , the protein was either bound to structures attached to the outside of the nucleus and had not penetrated the nuclear envelope or was loosely bound in the nucleus , ( iii ) at intermediate times , a low level of an intermediate form was observed in which the association of icp8 with the nuclear fraction was resistant to both detergent and dnase treatment .
C0028584
nuclear envelope
C0007610
nucleus