in a parallel activity-cardiotoxicity test in c3h mice repeatedly treated iv , 4-demethoxydoxorubicin , 4-demethoxy-4'-epidoxorubicin , 4-demethoxy-4'-o-methyldoxorubicin , and 4-demethoxy-4'-deoxydoxorubicin showed antitumor activity against mammary carcinoma without inducing the typical myocardial lesions observed after doxorubicin treatment , 4-demethoxy-4'-o-methyldoxorubicin , because of its high antitumor effectiveness , lack of cardiac toxicity in mice , and activity by the oral route , deserves further study .
C0014582
4
C0013089
doxorubicin