although the point of inhibitory attack of alpha-ketoacids in renal gluconeogenesis could not be localized , an impairment of the kidney to respond to metabolic acidosis with an increase of gluconeogenesis was observed , since the ph optimum of renal gluconeogenesis was shifted from ph 6.8 to ph 7.7 in the presence of alpha-ketoisovaleric acid .
C0035078
impairment
C0022646
renal