since cultured human fibroblasts have a limited replicative life span which features arrest in the g1 phase of the cell cycle , we sought to distinguish whether any changes in the proportions of the principal h1 histone subspecies ( h1a , h1b , and h1o ) in late-passage fibroblasts were specific for senescent loss of replicative potential , or rather ensued as a result of prolonged inhibition of cell division .
C0086418
human
C0019644
h1 histone