children ( n = 16 ) receiving multiple aed therapy had a higher clearance ( 23.5 vs 13.0 ml/hr/kg , p less than 0.001 ) , larger volume of distribution ( 0.30 vs 0.22 l/kg , p less than 0.01 ) , and shorter half-life ( 9.4 vs 12.3 hours , p less than 0.01 ) than did those ( n = 21 ) receiving vpa only .
C0003299
aed
C0042291
vpa