the observed pattern of tissue changes fell into four phases : a ) inflammation and necrosis followed by epithelial regeneration and hyperplasia , b ) development of localized regions of acanthosis , c ) loss of normal organization with downgrowth of epithelial cells and formation of keratin pearls , d ) appearance of well-defined nodules resembling verrucous carcinoma .
C0221270
acanthosis
C0206706
verrucous carcinoma