in conscious shr , 0.5 mg/kg ( i.p . ) of prazosin and 0.3 mg/kg ( i.p . ) of hydralazine lowered blood pressure to the same extent ( -22 mm hg ) , but prazosin again produced significantly larger increases in plasma norepinephrine concentration and norepinephrine spillover rate .
C0020649
lowered blood pressure
C0032912
prazosin