for the former schedule , dose-rate-limiting toxicity was related to mtx and included stomatitis developing at days 8 to 14 ( median , day 8 ) with the higher dose rates ( 1.5-2.0 mg/m2/day ) and thrombocytopenia developing at days 11 to 56 ( median , day 14 ) at the lowest dose rates ( 1.0 mg/m2/day ) .
C0025677
mtx
C0040034
thrombocytopenia