plasma concentrations of tissue-type plasminogen activator ( t-pa ) , urokinase ( u-pa ) , plasminogen activator inhibitor 1 ( pai-1 ) and pai-2 were studied in 53 patients with liver deficiency caused by chronic alcoholism ( n = 40 ) , viral hepatitis ( n = 10 ) or malignant disease of the liver ( n = 3 ) and compared to that of a control group ( n = 20 ) of healthy subjects . u-pa and pai-1 levels were significantly increased in all patients with chronic alcoholism , whereas high t-pa was only observed in combination with disturbed liver function tests or with liver cirrhosis ( two and six-fold above control values , respectively ) .
C0023895
disease of the liver
C0023890
liver cirrhosis