we have measured the time-course of estrogen receptor levels in nuclei of the estrogen-responsive breast tumor cell line mcf-7 during 90-120 min exposure of the cells to estradiol at physiologic ( 10 ( -10 ) m ) , pharmacologic ( 10 ( -6 ) m ) , and an intermediate ( 10 ( -8 ) m ) concentration .
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of the
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estradiol