investigating a role proposed for vitamin b6 deficiency , a regular finding in untreated celiacs , the present study yields no support for the hypothesis that direct inhibition at the decarboxylation step by vitamin b6 deficiency accounts for low central serotonin turnover in adult celiacs : 11 untreated patients showing reduced 5-hiaa in the cerebrospinal fluid ( 71+/- 26.8 pmol/ml ) had a significantly higher concentration of the metabolically active b6 vitamer pyridoxal 5'-phosphate in lumbar cerebrospinal fluid ( 0.06 +/- 0.34 ng/ml ) than controls ( 0.24 +/- 0.07 ng/ml ) ( p less than 0.01 ) .
C0936215
vitamin b6 deficiency
C0034266
pyridoxal 5