a total of 249 patients with advanced , symptomatic colorectal cancer who received no previous cytostatic therapy were randomly allocated to receive either fluorouracil ( 5-fu ) , 600 mg/m2 , for 2 days or the following regimen : sequential methotrexate , 250 mg/m2 , during the first 2 hours and 5-fu , 500 mg/m2 , at hours 3 and 23 followed by leucovorin rescue initiated at hour 24 ( 15 mg x 8 ) ( mfl ) .
C0016360
5-fu
C0251760
mfl