in this report we present evidence which suggests that pretreatment of a highly nitrosourea-resistant human colon tumor cell line with non-cytotoxic doses of streptozotocin ( stz ) prior to , or simultaneously with , 1,3-bis ( 2-chloroethyl ) -1-nitrosourea ( bcnu ) exposure produces synergistic increases in cytotoxicity of several logs over the cytotoxicity produced by exposure to bcnu alone .
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bcnu