the inability of nicotinamide to prevent the alloxan-induced impairment of proinsulin biosynthesis , insulin release , and oxygen uptake , together with the failure of nicotinamide to prevent the development of diabetes when given after alloxan , does not support a current hypothesis that the major cytotoxic effect of alloxan is primarily due to dna damage .
C0033362
proinsulin
C0021641
insulin