studies on the binding of mgi-2 to differentiation-competent ( d+ ) and differentiation-defective ( d- ) clones of mouse myeloid leukemic cells and to normal cells indicate that : ( 1 ) d+ clones of myeloid leukemic cells had about 2,500 high-affinity surface receptors per cell , like mature normal myeloid cells , and the bound mgi-2 was rapidly internalized with its cell-surface receptors at 37 degrees c causing down-regulation of mgi-2 receptors in both the normal and leukemic cells ;
C0007589
differentiation
C0007634
normal cells