for this purpose , we have induced a pulmonary embolus in anesthetized rats by injecting i125 radiolabeled clots into the venous circulation and we have measured the lysis of these clots occurring either spontaneously or induced by increasing doses of wild-type tissue plasminogen activator ( tpa ) ( from 0.125 to 2 mg/kg i.v . ) or by streptokinase ( 750,000 i.u./kg i.v . ) or urokinase ( 750,000 i.u./kg i.v . ) .
C0034065
pulmonary embolus
C0042071
urokinase