proposed mechanisms of antibiotic-induced acute renal tubular necrosis involve either altering plasma membrane permeability or interference with cellular energy derived from mitochondria , for either aminoglycoside or cephalosporin antibiotics , cellular accumulation followed by interruption of mitochondrial respiration is the concept that has greatest support , although the possibility of an induced phospholipidosis involving intracellular lysosomes can not be excluded .
C0007634
cellular
C0026237
mitochondrial