in a multiclinic double-blind trial , 305 patients with moderate to severe acne vulgaris were treated with oral tetracycline hydrochloride , 250 mg ( n : 103 ) , a 1 % solution of clindamycin phosphate ( n : 105 ) , or placebo ( n : 97 ) twice daily for 8 weeks .
C0001144
acne
C0546879
tetracycline hydrochloride