to study glucose counterregulation under conditions approximating those of clinical disorders in which hypoglycemia develops gradually and is reversed over a prolonged period , we injected regular insulin subcutaneously , in a dose ( 0.15 u/kg ) selected to produce two- to threefold increases in plasma insulin , in 11 normal human volunteers and measured plasma glucose , insulin , c-peptide , and counterregulatory hormone concentrations as well as rates of glucose production , glucose utilization , and insulin secretion over 12 h .
C0086418
human
C0006558
c-peptide