the concentration-response curves for the positive chronotropic effect of histamine and dimaprit ( s- [ 3- ( n , n-dimethylamino ) propyl ] isothiourea ) on atrium were displaced to the right in parallel without change in the maximum response by tzu-0460 with pa2 values of 6.56 and 6.74 and also for the relaxant effect on uterus with pa2 values of 6.81 and 6.65 , respectively .
C0058185
dimaprit
C0039958
isothiourea