to examine the interplay between the spleen and complement activation in host defense against pneumococcemia , serial colony counts in blood and survival rates were studied after high-dose ( 10 ( 5 ) ) and low-dose ( 10 ( 2 ) ) intravenous challenge with growth-phase streptococcus pneumoniae type 3 in rats with splenic remnants of varying size ( partial , total , or no splenic resection ) and with or without complement depletion ( by pretreatment with cobra venom factor [ cvf ] ) .
C0009528
complement activation
C0009498
complement