thus , pretreatment with verapamil prevented necrosis of severely ischemic myocytes , when reperfusion was established at 40 minutes , but failed to prevent necrosis of moderately ischemic myocardium and thus failed to limit infarct size when the period of coronary occlusion was prolonged to 3 hours and treatment was started 15 minutes after the onset of ischemia .
C0021308
infarct
C0022116
ischemia