( - ) -lofexidine showed an approximately 9-fold higher affinity than ( + ) -lofexidine for the alpha 2-adrenoceptor-like binding sites in rat brain membranes identified by [ 3h ] -clonidine and was 4 times more potent at displacing [ 3h ] -prazosin from alpha 1-adrenoceptors .
C0065152
alpha
C0009014
clonidine