using rna synthesized in isolated nuclei , we have measured the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin ( tcdd ) on the rate of synthesis of cytochrome p1-450 mrna in wild type mouse hepatoma ( hepa 1c1c7 ) cells and in variant ( bprc1 ) cells , which fail to accumulate the tcdd-receptor complex within the nucleus .
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cells
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nucleus