l-fenfluramine ( l-f ) was studied for its ability to release dopamine ( da ) and its metabolites in freely moving rats through the trans-striatal dialysis technique . l-f 's effect on striatal da release was also studied in animals made tolerant to the effect of haloperidol by chronic treatment ( 1 mg/kg i.p . twice daily for 11 days and 48 hr wash-out ) with the neuroleptic or pretreated with 300 mg/kg i.p . gamma-butyrolactone ( gbl ) .
C0018546
haloperidol
C0040615
neuroleptic