affinity for the dexamethasone binding sites of tixocortol pivalate , ( the ester of the 21 thiol derivatives of cortisol ) , a steroid with local anti-inflammatory activity similar to cortisol acetate and with no systemic activity , was investigated in comparison with other steroids : tixocortol ( the thiol derivative yielded by esterase hydrolysis ) , cortisol acetate and cortisol .
C0014894
esterase
C0020291
hydrolysis