additional studies , directly comparing hydroxygentamicin , a mutational biosynthetic , with gentamicin or netilmicin , all at 40 , 80 , and 160 mg base/kg , and incorporating renal function parameters as well as scr , bun , organ weight , tissue concentration , and kidney histopathology , revealed a characteristic pattern typical of aminoglycoside nephrotoxicity in mature adult male rats .
C0017436
gentamicin
C0002556
aminoglycoside