a similar clinical picture manifested by hyperthermia , hepatosplenomegaly , moderate lymphadenopathy , cutaneous changes in one of the brothers , increasing hypochromic anemia , thrombocytopenia , as well as similar morphologic changes ( marked histiocytic infiltration of the viscera , hemorrhages , necroses , neoplastic changes in the liver and lungs of one boy ) allowed differentiation of familial hemophagocytic histiocytosis from letterer-siwe disease in one family .
C0497156
lymphadenopathy
C0023381
letterer-siwe disease