serum disopyramide determinations and 24-hour holter monitoring were performed in 20 cardiac subjects with ventricular premature contractions ( vpcs ) after the first , seventeenth , and thirty-seventh doses of disopyramide , 100 mg ( 10 subjects ; low-dose group ) or 200 mg ( 10 subjects ; high-dose group ) every 6 hr for 10 days to assess the ability of single- or first-dose data to predict serum disopyramide concentrations at steady state and the relationship between steady-state serum disopyramide concentrations and vpc suppression .
C0012702
disopyramide
C0151636
vpc