ethane-1-hydroxy-1 , 1-diphosphonate ( ehdp ) was administered weekly for up to 15 months in either a high ( 50 mg/kg body weight ) or low ( 5 mg/kg body weight ) dose to the males of an inbred strain of mouse ( srt/ort ) which suffers from a high incidence of osteoarthrosis of the knee joint accompanied by extensive periarticular soft-tissue metaplasia forming cartilage and bone .
C0012544
diphosphonate
C0086268
ehdp