in this retrospective study in ten patients with essential hypertension a short-time treatment of 3 days with 0.15 mg clonidine 2 times/day orally , as well as a second short-term treatment period with the slow-release oral preparation ( .025 mg clonidine once/day ) significantly lowered blood pressure , heart rate , and plasma concentration of norepinephrine in the supine and standing subject .
C0020649
lowered blood pressure
C0028351
norepinephrine