consistent with previous studies suggesting that the expression of immediate-early and/or early viral gene products is required for the induction of chromosomal damage , was the observation that cells infected at the nonpermissive temperature with hsv-1 temperature-sensitive mutants defective in the gene for the immediate-early transcriptional regulatory protein , icp4 , and three early viral gene products -- dna polymerase ( pol ) , the major hsv dna-binding protein ( icp8 ) and an hsv-2 mutant defective in alkaline nuclease -- exhibited altered patterns of chromosomal damage relative to the effects of wild-type virus on infected cells .
C0042736
viral gene products
C0042776
virus