the hemoglobin ( hb ) binding of five nitroarenes , i.e . nitrobenzene ( nb ) , 4-nitrobiphenyl ( 4-nbp ) , 1-nitropyrene ( 1-np ) , 2-nitronaphthalene ( 2-nn ) and 2-nitrofluorene ( 2-nf ) , and the corresponding amines , administered p.o . to male s.d . rats , was determined by hplc , to evaluate the extent of in vivo reductive and oxidative activations of these compounds to n-hydroxylamines , which covalently bind to hb to form acid-labile sulfinamides .
C0002508
amines
C0020363
hydroxylamines