the sigmoid saturation pattern of h ( 4 ) folate ( n ( h ) = 2.0 ) , one of the substrates , the abolition of sigmoidicity by nadh , an allosteric positive effector ( n ( h ) = 1.0 ) and the increase in sigmoidicity by nad ( + ) and adenine nucleotides , negative allosteric effectors ( n ( h ) = 2.4 ) clearly established that this key enzyme in the folate metabolism was an allosteric protein .
C0027270
nad
C0001413
adenine nucleotides