interest in the mechanisms involved in the renal and extrarenal vascular actions of the newer diuretics has led to a better understanding of how changes in venous compliance , peripheral vascular resistance , and renal blood flow distribution may contribute to the overall therapeutic response to these agents , especially in patients with severe congestive heart failure , renal insufficiency with low glomerular filtration rates , and hypertension with cardiorenal complications .
C0022646
renal
C0035078
renal insufficiency