the antibody induced a dramatic and immediate depletion of peripheral t cells followed by an in vivo antigenic modulation of the okt3-defined membrane antigen : after three injections , okt3-treated patients showed a limited but significant number of okt3- cells of t cell nature ( as defined by okt4 and okt8 ) which recovered the okt3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody .
C0003241
antibody
C0003250
monoclonal