these results indicate that the active site and the protease-sensitive domain ( s ) of the microsomal n-acetyltransferase are localized on the outer surface ( cytoplasmic side ) of endoplasmic reticulum and that the ligandin ( s ) might protect membranous n-acetyltransferase from inhibition by organic anions by binding them and catalyzing the conjugation with glutathione .
C0010834
cytoplasmic
C0014239
endoplasmic reticulum