in untreated skin , this part is characterized by dermal inflammation , immigrating inflammatory cells , and specific keratinization disturbances : synthesis of keratinization proteins is suppressed , serum exudates invade the epidermis , either filling the intercellular spaces of the upper spinous and the granular layer as finely granular , amorphous material , or they are partly phagocytosed and lie within intracellular , round-oval inclusions .
C0014520
epidermis
C0221923
granular layer