in order to study the role of protein kinase c in mediating the inhibition of the glucocorticoid-dependent transcription from the mouse mammary tumor virus ( mmtv ) -long terminal repeat induced by overexpressed activated ras oncogene , we studied the effects of protein kinase c activators [ the tumor promoting phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) ] and inhibitors [ 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine ( h-7 ) ] on the dexamethasone ( dex ) -mediated activation of a mmtv-long terminal repeat-chloramphenicol acetyltransferase ( pmmtv-cat ) chimeric reporter gene transiently transfected into nih-3t3 cells and in ha-ras-transformed fibroblasts ( t24-nih-3t3 ) .
C0031586
phorbol ester
C0039654
12-o-tetradecanoyl-phorbol-13-acetate