quinine total clearances ( cl ) and total apparent volumes of distribution ( vd ) were significantly lower than in uncomplicated malaria ( cl , 0.92 +/- 0.42 compared with 1.35 +/- 0.6 ml/min/kg , p = 0.03 ; vd , 1.18 +/- 0.37 compared with 1.67 +/- 0.34 liter/kg , p = 0.0013 ) .
C0034417
quinine
C0024530
malaria