overall cardiac pump performance was significantly improved by mdl-17,043 , as reflected by an 88 % increase in stroke work index ( 17 +/- 11 to 32 +/- 19 gm-m/m2 ; p less than 0.001 ) , a 43 % reduction in left ventricular filling pressure ( 28 +/- 4 to 16 +/- 5 mm hg ; p less than 0.0001 ) , a 49 % reduction in systemic vascular resistance ( 1832 +/- 490 to 937 +/- 296 dynes-sec-cm-5 ; p less than 0.0001 ) with a slight ( 11 % ) decrease in mean arterial pressure ( 86 +/- 17 to 76 +/- 19 mm hg ; p = 0.005 ) and without significant changes in heart rate ( 88 +/- 14 to 91 +/- 12 bpm ; p = ns ) .
C0018787
cardiac
C0225897
left