model considerations indicate that in a unilayered , homogeneous epithelium with open lateral spaces the transient potential response across each cell membrane should obey a single exponential function in case the tight junction resistance is high , as in a tight epithelium , whereas in a leaky epithelium it should consist of a superposition of two exponentials with equal sign at the membrane with the higher intrinsic time constant and of two exponentials of different sign ( overshoot with recline ) at the membrane with the lower intrinsic time constant .
C0242358
tight junction
C0014609
epithelium