first , activation of spindle cells results initially in the increase in gap junctions between adjacent spindle cells , secondarily in the increase in cytoplasmic volume of rough endoplasmic reticulum , and ultimately in the synthesis and secretion of angiogenic factors second , maturation of spindle cells is associated with a decrease in gap junctions , a diminished cytoplasmic volume of rough endoplasmic reticulum , and a cessation of synthesis and secretion of angiogenic factors .
C0010834
cytoplasmic
C0230779
rough endoplasmic reticulum