topical metipranolol , 0.3 % and 0.6 % , blocked both the hypotension ( beta2-mediated ) and the tachycardia ( beta1-mediated ) elicited in ganglion-blocked , conscious rabbits by isoproterenol , 0.5 microgram/kg , i.v .
C0039231
tachycardia
C0022245
isoproterenol