the differentiation pattern of splenic t-cell populations in germ- and pathogen-free nu/nu mice , as compared to nu/+ littermates , is characterized by two abnormal features : the expression of tl determinants on peripheral t cells and the delayed onset of their differentiation from the predominant lyt-123 : tl+ set into tl- cells of lyt-1+ and lyt-123+ phenotype , which , in these mice , does not occur until 10 weeks of age .
C0007589
differentiation
C0007634
set