the hypothesis that azaperone reduced blood pressure by blocking alpha-adrenoceptors , thereby decreasing vasomotor tone , was tested by measuring the ability of azaperone ( 0-8 mg/kg ) to antagonise the action of standard intravenous doses of adrenaline ( 1-5 mug/kg ) on blood pressure , azaperone partially antagonised the pressor action of adrenaline and in comparative studies the phenothiazine tranquilliser , acepromazine ( 0-1 mg/kg ) , also exerted a similar blocking effect .
C0020649
reduced blood pressure
C0014563
adrenaline