these results are consistent with the hypothesis that proteases or nucleophilic agents effect the hydrolysis of an internal thiol-ester bond ( tack , b. f. , harrison , r. a. , janatova , j. , thomas , m. l. , and prahl , j. w. ( 1980 ) proc . natl . acad . sci . u. s. a . 77 , 5764-5768 ) , leading to an alteration in alpha 2-macroglobulin conformation .
C0020291
hydrolysis
C1418943
proc