articular chondrocytes cultured in the presence of recombinant human interleukin 1 alpha ( rhil-1 alpha ) or recombinant human tumor necrosis factor alpha ( rhtnf alpha ) caused increased production of the latent metalloproteinase ( collagenase and caseinase ) and the proteoglycan release from cartilage .
C0225369
chondrocytes
C0007301
cartilage