the shift to bicarbonate-selective from chloride-selective anion reabsorption during ecfv expansion in metabolic acidosis vs. metabolic alkalosis indicates that in response to ecfv expansion- the kidney selectively alters the ratio of bicarbonate to chloride concentration in the tubular reabsorbate in the direction that tends to normalize plasma acid-base composition , irrespective of the direction of deviation of the initial plasma bicarbonate concentration .
C0003075
anion
C0008203
chloride