to determine the effects of chronic dosage in mice , alprazolam ( 2 mg/kg/day ) was administered via osmotic pumps for 1-14 days , and open-field activity , plasma and brain concentrations , benzodiazepine receptor binding in vivo and in vitro , [ 35s ] t-butylbicyclophosphorothionate ( [ 35s ] tbps ) binding , and muscimol-stimulated chloride uptake were determined .
C0006104
brain
C0086045
concentrations