these results give rise to the question of whether the combination of carbamazepine , phenobarbitone , valproate , and/or phenytoin has teratogenic activity by accumulation of carbamazepine-10,11-epoxide or other epoxide intermediates , and stress the need to take metabolic interactions into account when investigating the teratogenic activity of antiepileptic drugs .
C0031507
phenytoin
C0003299
antiepileptic drugs