among the synthetic drugs possessing catechol moiety , isoproterenol , ( +/- ) -2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene ( 6,7-adtn ) and ( +/- ) -2-dimethylamino-6,7-dihydroxy-tetrahydronaphthalene ( tl-99 ) had the same inhibitory effects as the natural catecholamines ( ic50 between 1.6 and 3.9 microm ) , whereas the apomorphine derivatives and 2,3,4,5-tetrahydro-1-phenyl-1 h-3-benzazepine-7,8-diol ( skf 38393 ) were even more potent ( ic50 : 0.5-0.8 microm ) .
C0022245
isoproterenol
C0007412
catecholamines