1 a study was carried out in rats ( prepared for chronic sleep recording ) of the effects of oxolinic acid on the sleep-wakefulness cycle.2 in addition , the actions of oxolinic acid on the sleep-wake cycle were assessed after pretreatment with drugs interfering with central catecholamine mechanisms or facilitating central gamma-aminobutyric acid ( gaba ) activity.3 oxolinic acid ( 8-32 mg/kg ) induced a significant and dose-related increase of waking eeg , while slow wave and rem sleep were decreased.4 the effects of oxolinic acid on waking , slow wave and rem sleep were antagonized by alpha-methyl-p-tyrosine ( 50-100 mg/kg ) which interferes with the synthesis of catecholamines.5 fla-63 ( 25 mg/kg ) which is a specific inhibitor of noradrenaline synthesis , was effective in blocking oxolinic acid-related increase of waking and decrease of slow wave sleep.6 haloperidol ( 0.4-0.6 mg/kg ) which blocks central dopamine and noradrenaline receptors , reversed oxolinic acid-induced actions on waking and slow wave sleep .
C0007412
catecholamine
C0013030
dopamine