to investigate the effect of vagal blockade with atropine on nocturnal fall in peak expiratory flow rate 10 patients with asthma who had a diurnal variation in peak expiratory flow rate of greater than 20 % were given 30 micrograms/kg of intravenous atropine or a placebo at 4 am and 4 pm .
C0004096
asthma
C0004259
atropine