as demonstrated by one-dimensional and two-dimensional gel electrophoresis , immunoblotting , monoclonal antibody hisl-19 immunoaffinity chromatography , and immunoelectron microscopy , it is a water-soluble , acidic protein stored within secretory granules of peptide hormone-producing cells , and it is released in detectable amounts into the serum of patients bearing neuroendocrine carcinomas .
C0886515
secretory granules
C0007634
cells