based on a personal series of 6 cases , and about 20 cases reported in the published literature , the authors describe the principal characteristics of chronic distal amyotrophy of spinal origin : early onset or in young adults , initial disorder in lower limbs , especially anterolateral region of the legs , with secondary lesions in small muscles of the hands , absence of sensory disturbance , usually very slow progression , electrophysiological appearance of chronic denervation with normal conduction velocities , and neurogenic muscle lesions with unaffected peripheral nerve .
C0023216
lower limbs
C1140621
region