subsequent dose-ranging studies indicated that administration of lower doses of azithromycin ( 15 mg/kg/day given orally either once or twice daily , or 7.5 mg/kg/day given once daily ) was as effective as benzathine penicillin for therapy of active syphilis in this model , though the median time to darkfield negativity was significantly longer in the azithromycin-treated animals ( p less than 0.01 ) .
C0030829
benzathine penicillin
C0039128
syphilis