the paradox of cell type-specific morphological findings on the one hand and the generalized deficiency of n-acetylglucosamine-1-phosphotransferase representing the primordial enzyme deficiency in icd on the other , is resolved by postulating , outside the mannose-6-phosphate recognition marker targeting system , the existence of alternative mechanisms for distribution and processing of lysosomal enzymes in cells other than fibroblasts or endothelial cells .
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