swainsonine , a toxic plant alkaloid reported to be the agent that induces in animals a neurological condition very similar to the hereditary lysosomal storage disease mannosidosis , and to inhibit the formation of complex glycoproteins of the asparagine-linked class , was recently shown [ d.r.p . tulsiani , t.m . harris , and o. touster , ( 1982 ) j. biol . chem . 257 , 7936-7939 ] to be a highly potent and specific inhibitor of golgi mannosidase ii in addition to being a strong inhibitor of lysosomal mannosidase .
C0085535
swainsonine
C0002062
alkaloid