several laboratories , including our own have reported the synthesis and activity of certain low relative molecular mass inhibitors of mammalian serine proteases , especially human leukocyte elastase ( hle , ec 3.4.21.37 ) , an enzyme whose degradative activity on lung elastin has been implicated as a major causative factor in the induction of pulmonary emphysema , and which is present in the azurophil granules of human polymorphonuclear leukocytes ( pmn ) .
C0024109
lung
C0034067
pulmonary emphysema