one hundred fifty-seven premenopausal women with metastatic breast cancer were prospectively randomized to treatment consisting of oophorectomy + vincristine , prednisone , cyclophosphamide , methotrexate , 5-fluorouracil ( vpcmf ) ( reg . i ) or oophorectomy + cyclophosphamide ( reg . ii ) or oophorectomy followed by an observation period ( phase 1 ) , followed by vpcmf ( phase 2 ) ( reg . iii ) .
C0016360
5-fluorouracil
C0055987
vpcmf