the four cycle enzymes were constitutively localized in mitochondria , with the exception of the dual localization of the fourth enzyme , 2-methylisocitrate lyase , in mitochondria and cytoplasm , where the lyase may function to supply pyruvate ( the end-product of the catabolism of the propionate residue ) to various reactions .
C0026237
mitochondria
C0010834
cytoplasm