after 12 months of buserelin injections , the changes in hcg-stimulated rat testes are an increased ratio of progesterone/17-oh-progesterone ( inhibition of 17-hydroxylase ) , a reduced capacity for secretion of androstenedione and testosterone ( block of 17,20-desmolase ) , and increased 5 alpha-pregnane-3,20-dione ( this steroid inhibits the 17,20-desmolase , similarly to progesterone ) .
C0033006
pregnane
C0038317
steroid