in contrast , inhibition of alpha-ketoisocaproic acid-induced insulin release occurs after a lag period and is not reversed by removal of the inhibitor . alpha-ketoisocaproic acid , at equimolar concentrations , is several-fold more effective than glucose in elevating camp content in islet . alpha ketoisocaproic acid and glucose are about equally effective in stimulating somatostatin release from isolated rat pancreatic islets .
C0021641
insulin
C0022131
pancreatic islets