to test the hypothesis , that cardiac glycosides might be transported into a distinct compartment of the myocardium with the na+-k-atpase acting as a carrier , the interaction of some inhibitors of this enzyme ( digitoxin , dihydroouabain , cassaine , n-ethylmaleimide , p-hydroxy-mercuribenzoate , ethacrynic acid , spironolactone ) with ouabain was studied at different levels of cardiac glycoside actions : myocardial function , cardiac uptake and subcellular distribution and binding to the na+-k+-atpase .
C0027061
myocardial
C0018787
cardiac