the effects of delta 9-tetrahydrocannabinol ( delta 9-thc ) , two of its metabolites , 8 beta-hydroxy-delta 9-thc and 11-hydroxy-delta 9-thc , and cannabidiol were comparatively studied by means of an iron-induced cortical focal epilepsy in conscious rats with chronically implanted electrodes . delta 9-tetrahydrocannabinol produced depression of the spontaneously firing epileptic focus , excitatory behavior , generalized after-discharge-like bursts of epileptiform polyspikes and frank convulsions .
C0014544
epileptic
C0036572
convulsions