gamma-phosphonate analogues of methotrexate ( mtx ) and aminopterin ( amt ) were synthesized from 4-amino-4-deoxy-n10-methylpteroic acid and 4-amino-4-deoxy-n10-formylpteroic acid , respectively , by reaction with methyl d , l-2-amino-4-phosphonobutyrate followed by gentle alkaline hydrolysis .
C0025677
methotrexate
C0002583
aminopterin