when the ability of some synthetic analogs of retinoic acid to compete with [ 3h ] retinoic acid binding on human skin crabp was studied , two important observations were made : ( 1 ) the analogs that , when given to human subjects were pharmacologically active , were found to be good competitors and vice-versa , ( 2 ) no strict correlation was found between the ic50 and the pharmacological potency of the retinoid .
C1514916
retinoic acid binding
C0599344
crabp