one of the two major antigenic domains ( a ) , composed of three different epitopes , completely lost its antigenicity upon incubation at ph 5.0 or by treatment with guanidine-hcl/urea , sds , reduction and carboxymethylation , as well as by proteolytic ( trypsin , alpha-chymotrypsin , thermolysin ) and chemical ( cnbr ) fragmentation .
C0003320
antigenic
C0003316
epitopes