pergolide mesylate , a semisynthetic ergoline and a potent , long-acting central dopamine agonist , was tested in 13 patients with advanced parkinson disease and diurnal oscillations in performance ( `` '' wearing-off '' '' or `` '' on-off '' '' phenomena or both ) whose response to levodopa had diminished considerably .
C0030567
parkinson disease
C0023570
to levo