results on the molecular control of growth and differentiation in normal myeloid haemopoietic cells , changes in the normal developmental programme in myeloid leukaemia , and the suppression of malignancy in myeloid leukaemia and sarcomas have shown that ( 1 ) malignancy can be suppressed either with or without genetic changes in the malignant cells , ( 2 ) suppression of malignancy by inducing differentiation does not have to restore all the normal controls , and ( 3 ) genetic abnormalities which give rise to malignancy can be bypassed and their effects nullified by inducing differentiation which stops cells from multiplying .
C0007589
differentiation
C0007634
cells