to study the natural history of corticosteroid-dependent asthma , we evaluated 40 randomly selected adult patients with severe asthma who were refractory to management with inhaled corticosteroids and bronchodilators and who required long-term prednisone therapy ( mean duration , 6.2 +/- 5.1 years ) .
C0004096
asthma
C0032952
prednisone