normal feedback regulation suggests that diurnal episodic hypersecretion of gh reflects an abnormality at or above the level of the hypothalamus , so that the ghrh-gh-somatomedin axis hyperactivity observed in certain patients with major depressive disorder may be due , at least in part , to hypersecretion of hypothalamic ghrh .
C0020663
hypothalamic
C0037668
ghrh