within 8.5 hr of tpa treatment , a period preceding mitosis , a large percentage of the most dense basal-cell keratinocytes ( greater than or equal to 1.074 g/cm3 ) were converted to cells with a lower density , with a reduced plating efficiency and with an increased rate of differentiation , suggesting that tpa induces a subpopulation of basal cells to commit to terminal differentiation , and accelerates the rate of differentiation of committed cells .
C0026255
mitosis
C0007634
cells