analysis of the variant proteins expressed in e. coli showed that these substitutions affected , to varying extents , recognition by both anti-fimbrial and anti-fmdv antibodies , indicating that hypervariable region 2 is a major antigenic determinant of the fimbrial subunit and that local stereochemical effects can influence antibody binding to the fmdv peptide antigenic determinant .
C0003320
antigenic
C0003316
antigenic determinant