these agents do not inhibit the rise in uterine cgmp content provoked by sodium nitroprusside , thus arguing against a direct toxic effect on the enzyme guanylate cyclase . alpha-amanitin , even at very high concentrations ( 80 micrograms/ml ) , interfered much less efficiently with total rna and protein synthesis and also failed to prevent the oestrogen-induced increase in cgmp content .
C0035668
rna
C0597295
protein