the characteristic features of the intracellular distribution of sisomicin ( build up of high levels of the free antibiotic in the cytoplasm and relatively easy dissociation of the antibiotic complexes with the organoids of the kidney cortical layer ) may define the higher activity of sisomicin as compared to that of gentamicin against intracellularly located microorganisms and its lower potential nephrotoxicity .
C0037209
sisomicin
C0017436
gentamicin