this km channel was less sensitive to the cytoplasmic ca2+ concentration , [ ca2+ ] i , but was sensitive to the extracellular ca2+ , [ ca2+ ] o , e. g. in the outside-out membrane patch , lowering the [ ca2+ ] o in the bath markedly reduced the open probability of this channel , and also in cell-attached configuration , lowering of the [ ca2+ ] o using the internally perfused patch clamp electrode device reduced the opening of km channel .
C0010834
cytoplasmic
C0007634
cell