1 prostaglandin e ( 2 ) dose-dependently and reversibly inhibited the noradrenaline overflow resulting from nerve stimulation of the rabbit kidney.2 the magnitude of this inhibition varied inversely with the frequency of stimulation employed.3 the prostaglandin synthesis inhibitors , indomethacin and meclofenamic acid , both increased the transmitter overflow resulting from renal nerve stimulation , suggesting that endogenous prostaglandin has a role in the regulation of transmitter release.4 in the presence of indomethacin , the inhibitory effect of exogenous prostaglandin e ( 2 ) was enhanced.5 the prostaglandin precursor , arachidonic acid , also caused a significant , dose-dependent and reversible inhibition of transmitter overflow .
C0033559
prostaglandin e
C0033554
prostaglandin