to test the hypothesis that sulfonylureas enhance insulin action by activating the insulin receptor tyrosine kinase , the effects of glyburide , a second generation sulfonylurea , and ciglitazone , a nonsulfonylurea hypoglycemic agent , were determined in primary cultures of rat hepatocytes on insulin action and insulin receptor structure and function .
C0038766
sulfonylureas
C0017628
glyburide