the id50 against dihydrofolate reductase was comparable for the mtx and amt analogues ( 0.04-0.07 microm ) , whereas the id50 against folyl polyglutamate synthetase was 3- to 4-fold lower for the amt analogues ( 40-60 microm ) than for the mtx analogues ( 100-200 microm ) .
C0002583
amt
C0025677
mtx