conversely , when 12 normal volunteers took loperamide capsules sufficient to cause symptomatic constipation and to prolong mean transit-time from 48 to 103 hours , the deoxycholic acid pool increased from 0.40 +/- 0.24 to 0.57 +/- 0.17 g ( p = 0.008 ) .
C0023992
loperamide
C0009806
constipation