the intravenous administration of d-sotalol , four 8 mg/kg doses over a 24-hour treatment period , suppressed the induction of ventricular tachycardia by programmed electrical stimulation in six of nine dogs tested , slowed the rate of the induced tachyarrhythmia in two of the remaining three dogs , and provided significant protection ( 5 of 8 d-sotalol vs 0 of 8 vehicle control ) against the development of ventricular fibrillation in response to ischemia at a site distant to a previous myocardial infarction .
C0042514
ventricular tachycardia
C0037707
sotalol