administration of alloxan to rana temporaria in a dose of 300 mg/kg caused a complex of reactive changes in the pancreas ( degranulation of b-cells , of acino-islar cells of b type , and of the exocrine pancreocytes ; edema of the secretory granules , lysosome activation , disturbance of the secretory cycle course ) , which were irreversible in the majority of cells .
C0024369
lysosome
C0007634
cells