1 the actions of 5-methoxytryptamine ( 5-meot ) , n , n-dimethyltryptamine ( dmt ) , 5-hydroxy-n , n-dimethyltryptamine ( bufotenine , 5-hodmt ) and 5-methoxy-n , n-dimethyltryptamine ( 5-meodmt ) , and their interactions with 5-hydroxytryptamine ( 5-ht ) , acetylcholine , ( - ) -noradrenaline , and glutamate were studied by microiontophoresis on single neurones in the brain stem of rats anaesthetized with urethane or decerebrate cats.2 like d-lysergic acid diethylamide ( lsd 25 ) the three psychotomimetic derivatives ( dmt , 5-hodmt , 5-meodmt ) specifically antagonized 5-ht excitations of single neurones , but the non-psychotomimetic 5-meot had no antagonistic effects.3 in contrast to lsd 25 , the psychotomimetic tryptamines only rarely antagonized glutamate effects , indicating that the excitatory 5-ht receptors and the glutamate receptors on the same neurones may be closely related spatially , but are separate.4 the methylated tryptamine derivatives were able to mimic the actions of 5-ht on neurones .
C0000589
methoxytryptamine
C0036751
5-ht