this is derived from observations of a genetically determined predisposition , an association of recent-onset diabetes with viral infections , an inflammatory cell infiltrate affecting the islets of langerhans , autoantibodies against islet cells , insulin , insulin receptors , and other organ-specific or non-organ-specific antigens , as well as abnormalities of cell-mediated immunity and of non-antigen specific mediators .
C0022131
islet cells
C0021641
insulin