clinical trials with a new class of drugs that inhibit the rate-limiting enzyme in cholesterol biosynthesis , 3-hydroxy-3-methylglutaryl coenzyme a ( hmg coa ) reductase , and that includes lovastatin , simvastatin , and pravastatin indicate that these drugs lower ldl cholesterol concentrations by 30 % to 50 % in patients with heterozygous fh .
C0008377
cholesterol
C0023824
ldl cholesterol