to verify whether a mild , but prolonged liver injury by chemicals needing bioactivation causes both hepatic cirrhosis and the appearance of hepatocyte nodules and tumors ( providing the liver has been exposed previously to initiating stimuli ) , diethylnitrosamine-initiated and uninitiated rats were administered thioacetamide at low dose ( 250 mg/l drinking water ) for 6 months .
C0023890
hepatic cirrhosis
C0023884
liver