patients with zollinger-ellison syndrome whose gastric acid secretion or symptoms were not controlled by cimetidine in conventional dosage were selected for studies of responsiveness of their acid secretion to increasing doses of cimetidine , used either alone or in combination with a long-acting anticholinergic agent , isopropamide iodide .
C0043515
zollinger-ellison syndrome
C0008783
cimetidine