repeated electroconvulsive shock was similarly without effect.4 ten hours after the final dose of desmethylimipramine ( 10 mg kg ( -1 ) ) once daily for 10 days there was no change in the usual dark phase increase in pineal melatonin.5 the data suggest that repeated administration of certain antidepressant drugs results in reduced pineal beta-adrenoceptor sensitivity .
C0011685
desmethylimipramine
C0003289
antidepressant