in the setting of a profound immune dysfunction , as in the case of acquired immune deficiency syndrome ( aids ) , renal transplant recipients under immunosuppressive therapy , and other iatrogenically immunosuppressed patients ( the three groups in which ks has been most frequently observed ) , the specific involvement of cmv oncogenes , of which at least two have been so far identified in experimental systems , is strongly indicated .
C0021053
immune dysfunction
C0085393
immunosuppressed