the proenzyme of a ca2+-dependent protease-activated protein kinase previously obtained from mammalian tissues ( inoue , m. , kishimoto , a. , takai , y. , and nishizuka , y . ( 1977 ) j. biol . chem . 252 , 7610-7616 ) was enzymatically fully active without limited proteolysis when ca2+ and a membrane-associated factor were simultaneously present in the reaction mixture .
C0006784
ca2
C0597304
proteolysis