these observations , together with the findings of absolute dependence of poly ( adp-ribose ) synthetase activity on dna strand ends and extensive automodification of the synthetase in dna-damaged cells , suggested a possible mechanism of poly ( adp-ribose ) action in dna repair , in which auto-modified poly ( adp-ribose ) synthetase serves as a link between dna damage and activation of dna ligase .
C0012899
dna repair
C0012860
dna damage