in a search for a selective inhibitor for the epinephrine synthesizing enzyme phenylethanolamine n-methyltransferase ( pnmt ; ec 2.1.1.28 ) , phenolic 2-aminotetralins ( 12-15 as conformationally restricted analogues of tyramine ) and phenolic benzobicyclo [ 3.2.1 ] octylamines ( 22-24 as conformationally defined analogues of tyramine ) were used to gain information about the binding interactions of the catecholic hydroxyl groups in the natural substrate norepinephrine at the active site of pnmt .
C0014563
epinephrine
C0028351
norepinephrine