in l-m ( murine tumorigenic fibroblasts , highly sensitive to tnf cytotoxicity ) cells and hel ( human embryonic lung cells , non-sensitive to tnf cytotoxicity ) cells , receptor-bound 125i-labelled recombinant human tnf was rapidly internalized and delivered to lysosomes within 15-30 min , and this was followed by degradation and release into the culture medium .
C0007634
cells
C0024369
lysosomes