recent investigations on possible mechanisms of nickel carcinogenesis are reviewed , emphasizing cellular uptake and intracellular translocation of nickel , morphological transformation of cells by nickel compounds , chromosomal damage , dna strandbreaks and dna-protein complexes produced by nickel compounds , mutagenic effects of nickel , influence of nickel on the helical transition of b-dna to z-dna , nickel-induced infidelity of dna synthesis , free radicals and lipid peroxidation induced by nickel exposures , nickel inhibition of dna repair , nickel as a tumor promotor , nickel inhibition of natural-killer ( nk ) cell activity , manganese and magnesium antagonism of nickel carcinogenesis , and speculation that ni2+ might replace zn2+ in finger-loop domains of transforming proteins .
C0012854
dna
C0043442
z-dna