in order to clarify whether a dietary fiber has any effect upon the intestinal absorption of sulfonylurea , changes in plasma concentration of glibenclamide were determined during a six-hour period in nine healthy volunteers who took 2.5 mg of glibenclamide together with a breakfast and 3.9 g of glucomannan in a form of konjac powder and were compared with those of the control experiment in which the same amount of the hypoglycemic agent was given without the dietary fiber .
C0038766
sulfonylurea
C0017628
glibenclamide