this review considers the five major principles governing optimal dosing of beta-lactam antibiotics in therapy for bacterial meningitis : off the entry of passage of antibiotics into csf , ( 2 ) the antimicrobial activity of beta-lactams within the purulent csf in vivo , ( 3 ) the bactericidal activity within the csf , ( 4 ) the route and mode of drug administration together with the postantibiotic effect , and ( 5 ) the duration of therapy .
C0026458
beta-lactam antibiotics
C0282215
beta-lactams