kinetic data for the antibiotic-modifying enzyme kanamycin acetyltransferase aac ( 6 ' ) -iv have been determined for five aminoglycoside antibiotics ( amikacin , gentamicin c1a , kanamycin a , sisomicin , and tobramycin ) and compared with close-interval determinations of the minimal inhibitory concentrations of the same antibiotics against escherichia coli w677 harboring the resistance plasmid pmh67 .
C0002499
amikacin
C0022487
kanamycin