the in vivo effects of four psychomotor stimulants ( d-amphetamine , beta-phenylethylamine , cocaine and methylphenidate ) were determined on : 1 ) the rate of dopamine ( da ) synthesis , as measured by the accumulation of dihydroxyphenylalanine ( dopa ) after aromatic l-amino acid decarboxylase inhibition , in the striatum ( terminals of nigrostriatal neurons ) and in the nucleus accumbens and olfactory tubercle ( terminals of mesolimbic neurons ) and 2 ) the efflux of the da metabolite 3,4-dihydroxyphenylacetic acid ( dopac ) into cerebroventricular perfusates of conscious , freely-moving rats . d-amphetamine and beta-phenylethylamine produced biphasic responses with lower doses of each drug increasing both the efflux of dopac and the rate of da synthesis in the striatum .
C0011812
d-amphetamine
C0002658
amphetamine