in our probing of the structural features responsible for the inhibitory activity of aminoglutethimide [ 1 , 3- ( 4-aminophenyl ) -3-ethylpiperidine-2,6-dione ] toward the cholesterol side-chain cleavage enzyme system desmolase and the estrogen-forming system aromatase , targets in the action of 1 against hormone-dependent mammary tumors , analogues in several categories have been synthesized and evaluated .
C0002555
aminoglutethimide
C0027661
hormone-dependent