because of the fact that haemodynamic studies in man and studies on the possible correlation between the structure of these drugs and their negative inotropic effect are lacking , we have investigated the influence on myocardial contractility of cat papillary muscle induced by impramine and dimetacrin as well as their desmethyl compounds ( n = 42 ) .
C0027061
myocardial
C0030352
papillary muscle