as a sequel to our previous paper , which emphasized the role conserved residues in cdr-1 and cdr-2 of vh play in general shaping of the primordial antigen-binding cavity , here we propose that the three short clusters of amino acid sequences in cdr-1 and cdr-2 that are placed in the immediate vicinity of the tryptophan loop primarily determine subgroup-dependent antigen preference of individual vh , therefore , antibodies .
C1148575
antigen-binding
C0003241
antibodies