in our rat model for aml , the transplantable brown norway myeloid leukaemia ( bnml ) , near total suppression of haemopoiesis was observed in a relatively early stage of the disease because of the physical disappearance of haemopoietic stem cells ( hsc ) from the bone marrow , which was only partly compensated by an increased number of hsc in the spleen .
C0023470
myeloid leukaemia
C0005953
bone marrow