based on the cholinergic-deficiency hypothesis of tardive dyskinesia ( td ) , we administered cytidine diphosphoryl choline ( cdp-choline ) ( a naturally occurring biochemical intermediary in the synthesis of phosphatidylcholine ) , 500 mg twice a day orally , to four women and one man with td for 2 to 8 weeks in a double-blind , placebo-controlled crossover trial .
C0008405
choline
C0010725
cdp-choline