since activation of protein kinase c ( pkc ) is known to cause rapid down-regulation of various receptors , including the t cell receptor complex ( tcr complex ) , we treated cells with phorbol 12-myristate 13-acetate ( pma ) , a pkc activator , to determine whether cell-surface expression of cd4 and cd8 would be similarly affected by this intracellular mediator .
C0007634
cells
C0699040
cell-surface