the observation that anti-immunoglobulin antibodies and t cell-replacing factor ( trf ) have a synergistic effect on the stimulation of b lymphocytes to differentiate into antibody-secreting cells suggested to us the possibility that the crosslinking of b-cell surface immunoglobulin by antigen or anti-immunoglobulin antibody might induce the expression of a b-cell receptor for trf .
C1155003
stimulation
C0003320
antigen