in order to investigate whether the sex differentiated response to 2-aaf selection and 2-aaf carcinogenesis might be due to pituitary control of xenobiotic metabolism , as previously shown for rat liver metabolism of steroid hormones , we have studied the influence of age , sex and pituitary hormones on the cytochrome p-450-mediated hydroxylations of 2-aaf and benzo [ a ] pyrene ( b [ a ] p ) , o-deethylation of 7-ethoxyresorufin and the metabolism of 4-androstene-3,17-dione ( androstenedione ) in rat liver microsomes .
C0010762
cytochrome p-450
C0025519
metabolism