the hypothesis that large fluctuations in weight during young adulthood are associated with increased risk of coronary heart disease was investigated by comparing the 25-year mortality of three groups of middle-aged men with distinctly different patterns of self-reported weight during young adulthood : 98 men who reported large gains and large losses , 133 who reported large gains and no losses , and 178 who reported no substantial change in weight .
C0005910
weight
C0005911
change in weight