in addition to being three to four times more potent than tolbutamide , mcn-3495 also differs from the sulfonylureas in lowering blood glucose concentrations of streptozotocin-diabetic rats and db/db mice , and , moreover , oral administration to normal fasted dogs did not produce the characteristic rise in insulin concentrations observed with tolbutamide .
C0038766
sulfonylureas
C0040374
tolbutamide