dogs given 1.0 g of primidone orally ( 59.2 decreasing to 50.5 mg/kg of body weight ) for 21 days accumulated the phenobarbital metabolite with apparent steady-state concentrations of 10 to 20 micrograms/ml and phenylethylmalonamide in concentrations of 2 to 5 micrograms/ml .
C0033148
primidone
C0031412
phenobarbital