human recombinant alpha-interferon 2a ( alpha-ifn ) , administered to 10 patients at a dose of 3 x 10 ( 6 ) iu/d s.c. for 11 +/- 3 weeks , was capable of inducing a significant ( p less than 0.01 ) decrease in the number ( from 72 +/- 16 to 31 +/- 14 ) and size of bone marrow cfu-mk , together with a significant reduction of the platelet count ( from 1031 +/- 325 to 378 +/- 75 x 10 ( 9 ) /l ) .
C0021734
recombinant alpha-interferon 2a
C0040034
reduction