in vivo , prolonged polyclonal activation of b cells by the nonantigenic but potent mitogenic lipid a portion of lipopolysaccharide ( lps-r595 ) resulted in acceleration of the late life systemic lupus erythematosus disease of female mrl/n , bxsb , and nzw mice , mimicking the time , form , and histopathological features characteristic of their early life disease counterparts , i.e. , mrl/l females , bxsb males , and ( nzb x nzw ) f1 females .
C0023767
lipid a
C0023810
lps