a combined biochemical and conformational study [ brasseur et al. , biochem . pharmac . 33 , 629 ( 1984 ) ] showed major and consistent differences between 6 aminoglycosides in current clinical use with respect to the stability of the complexes they form with phosphatidylinositol , their inhibitory potency towards the activity of lysosomal phospholipases and their current toxicity ranking ( e.g . gentamicin greater than amikacin greater than streptomycin ) .
C0002556
aminoglycosides
C0002499
amikacin