in contrast , dogs receiving dopamine exhibited more myocardial edema ( 3.3 % versus 1.7 % water gain ) , worse ventricular compliance ( 18 % versus 55 % recovered at 25 ml left ventricular volume ) , poorer contractility ( 58 % versus 70 % recovery of +dp/dt ) , generated 50 % less stroke work at a left atrial pressure of 25 mm hg ( 0.25 versus 0.52 gm/kg ) , failed to augment oxygen uptake to meet the metabolic demands of the working heart ( 11 % versus 45 % increase in oxygen uptake ) , and required continued inotropic support to discontinue extracorporeal circulation .
C0027061
myocardial
C0018787
heart