it is of interest that nsp4 contains the gly-asp-asp motif characteristic of a number of viral replicases , and this , together with the fact that all rna synthesis in ts6-infected cells and , to a lesser extent , in ts110-infected cells shut off when the cells were shifted from a permissive to a nonpermissive temperature , suggests that nsp4 is the virus polymerase .
C1521970
characteristic
C0039476
temperature