the effects of viscosity on the kinetic constants of netilmicin , gentamicin c1 , and sisomicin aminoglycoside substrates are as follows : no change in the substrate inhibition constants of all three antibiotics , a small but significant and highly unusual increase in vmax/km for netilmicin but large , normal decreases for gentamicin c1 and sisomicin , and marked decreases in the maximal velocities for all three .
C0027780
netilmicin
C0037209
sisomicin