we have concluded from these observations that ( 1 ) cholesterol side-chain cleavage and pregnenolone conversion to progesterone are essential for gonadotropin-promoted follicle steroid production and the resulting reinitiation of meiosis by the oocyte , ( 2 ) the enzymes necessary for the conversion of cholesterol to 17 alpha-oh,20 beta-dhp , t , and e2 are present in the unstimulated , prematurational follicle , and ( 3 ) gonadotropin initiates steroidogenesis by acting at a step prior to the conversion of cholesterol to pregnenolone ;
C0029045
oocyte
C0018120
follicle