the adenylate cyclase activator forskolin ( 1-100 microm ) mimicked tsh in increasing tpo mrna levels whilst , in contrast , the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate ( tpa ; 0.01-1 microm ) led to levels of tpo mrna that were lower than basal .
C0031586
phorbol ester
C0039654
12-o-tetradecanoyl phorbol 13-acetate