however , very soon after infection , intracytoplasmic rickettsiae began to escape from the host cell into the medium in large numbers , resulting in ( i ) failure of large numbers of rickettsiae to accumulate in the cytoplasm , ( ii ) sustained rapid division of the organisms in the cytoplasm , ( iii ) substantial accumulation of extracellular rickettsiae , and ( iv ) rapidly spreading infection in the culture , with most cells infected in 48 to 72 h .
C0010834
cytoplasm
C0007634
cells