1- ( 7-carboxyheptyl ) imidazole was identified as the most potent and selective inhibitor of thromboxane synthetase and was used with indomethacin to investigate the relative contribution of the prostaglandin endoperoxides prostaglandin g ( 2 ) ( pgg ( 2 ) ) /pgh ( 2 ) and txa ( 2 ) in mediating platelet aggregation induced by collagen or aa.3 platelet aggregation induced by a low concentration of collagen was abolished by indomethacin and carboxyheptylimidazole whilst in response to a high concentration or collagen only partial inhibition of aggregation occurred.4 the contribution of adenosine diphosphate ( adp ) released from platelets during collagen or aa-induced aggregation was examined using the substrate/enzyme complex creatine phosphate/creatine phosphokinase ( cp/cpk ) .
C0033541
prostaglandin endoperoxides
C0033563
pgg