in a series of immortalized human bronchial epithelial cell lines continuing various oncogenes , the transcriptional levels of the type iv collagenase and the type iv procollagen genes were compared with the properties of invasiveness in vitro and tumorigenicity and metastatic ability in athymic nude mice . v-ha-ras greatly enhanced invasion and metastasis , whereas v-ki-ras , c-myc , and c-raf had lesser effects on these malignant phenotypes .
C0040649
transcriptional
C0086661
c-myc