such recognized associations include the cessation of mitosis through inhibition of dna replication by a g1-inhibitor present in the suprabasal cells , the biosynthesis of a tonofilament-protein as an early event in keratinization , the biosynthesis of hrp0 ( histidine-rich protein ) and its polymerization to hrpi during the formation of keratohyalin , the conversion of hrpi to hrpii coincident with the loss of the nucleus from the granular cell , and the aggregation of the stratum corneum basic protein and keratin filaments to form fibers in the cornified cell .
C0026255
mitosis
C0007634
cell