in vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen aflatoxin b1 ( afb1 ) to its genotoxic 2,3-epoxide derivative is cytochrome p-450nf ( p-450nf ) , a previously characterized protein that also catalyzes the oxidation of nifedipine and other dihydropyridines , quinidine , macrolide antibiotics , various steroids , and other compounds .
C0028066
nifedipine
C0012315
dihydropyridines