in addition to the more obvious neuronal cytoplasmic vacuolization known to occur , studies extended to a broader age range of wobbler mice have revealed neuronal alterations such as nonvacuolar dissolution of granular endoplasmic reticulum , proliferation of cytoplasmic microtubules and neurofilaments , proliferation of branched tubules resembling smooth endoplasmic reticulum , development of lipid droplets , and increased numbers of pleomorphic dense and lamellar cytoplasmic bodies .
C0230704
lipid droplets
C0010834
cytoplasmic