long-term administration of high doses of 13-cis-retinoic acid ( 240 mg/kg of diet ) or all-trans-retinoic acid ( 65 mg/kg of diet ) produced lethal toxicity in this strain of rats , possibly due to interference with vitamin k absorption and the resulting internal hemorrhages associated with hypoprothrombinemia .
C0042878
vitamin k
C0020640
hypoprothrombinemia