( 1 ) the maximal insulin stimulation of 2-deoxyglucose transport and lipogenesis in fat-cells was selectively inhibited ( 73-88 % ) by n alpha-p-tosyl-l-lysine chloromethyl ketone ( tos-lys-ch2cl ; active-site inhibitor of trypsin ; 30-125 microm ) , p-nitrophenyl p'-guanidinobenzoate ( active-site inhibitor of serine proteinases ; 30-125 microm ) and p-tosyl-l-arginine methyl ester ( arginine ester substrate analogue of proteinases ; 1-2 mm ) , under conditions where neither the basal rate of each metabolic process nor insulin binding nor cellular atp content were affected .
C2717971
serine
C0030940
proteinases