the metabolic pathogenesis of the complex renal tubular dysfunction of type ii renal tubular acidosis and fanconi 's syndrome ( rta ii/fs ) acutely induced by maleic acid could depend on the occurrence of a positive feedback loop in cells of the proximal renal tubule : impaired mitochondrial oxidation -- -- increased glucose uptake -- -- increased formation and concentration of phosphorylated glycolytic intermediates -- -- limitation on availability of cellular inorganic phosphate -- -- more severely impaired mitochondrial oxidative metabolism .
C0026237
mitochondrial
C0282636
oxidative metabolism