a metabolic study with tissue from a virilizing arrhenoblastoma , using as precursors [ 7-3h ] pregnenolone , [ 7-3h ] 17alpha-hydroxypregnenolone , [ 4-14c ] 17alpha-hydroxyprogesterone and [ 4-14c ] testosterone , revealed that in spite of a deficient activity of 3beta-hydroxysteroid dehydrogenase-5-isomerase the overall production of testosterone was compensated by an increased activity of a lyase converting [ 4-14c ] 17alpha-hydroxyprogesterone to testosterone ( via androstenedione ) and was comparable to the production obtained by normal ovarian tissue .
C0003810
arrhenoblastoma
C1518744
normal ovarian tissue