the significance of the lipid a portion of lipopolysaccharide for the induction of ltc4 was indicated by demonstrating that peritoneal macrophages of endotoxin-low-responder mice or of mice rendered tolerant to endotoxin did not respond with the release of arachidonic acid metabolites on stimulation with re-mutant lipopolysaccharide and that polymyxin b prevented the re-lipopolysaccharide-induced ltc4 and pge2 release .
C0023767
lipid a
C0023810
lipopolysaccharide