it is concluded that calcification of glutaraldehyde-preserved porcine aortic valves implanted subcutaneously in rats begins within 48 hours , earliest deposits are localized to residual porcine connective tissue cells , but latter deposits also involve collagen fibrils , mineralization is most prominent in the spongiosa , the pathology of calcification in rat subcutaneous implants and calf mitral replacements is comparable , suggesting a common pathophysiology , and calcific nodule formation most likely initiates clinical features .
C0333562
deposits
C0006663
pathology