evidence was obtained that chlorpromazine administration for a 3- or 7-wk period at doses comparable on a weight basis to those used clinically has significant effects upon riboflavin metabolism in the animal as a whole : ( a ) the activity coefficient of erythrocyte glutathione reductase , an fad-containing enzyme used as an index of riboflavin status physiologically , was elevated , a finding compatible with a deficiency state , ( b ) the urinary excretion of riboflavin was more than twice that of age- and sex-matched pair-fed control rats , and ( c ) after administration of chlorpromazine for a 7-wk period , tissue levels of flavin mononucleotide and fad were significantly lower than those of pair-fed littermates , despite consumption of a diet estimated to contain 30 times the recommended dietary allowance .
C0005910
weight
C0037088
finding