the most important finding was that langerhans ' cells appear in increased numbers in the epidermis very early in the disease , even preceding the experience of lymphocytes there and then that the appearance of lymphocytes is followed by destruction of keratinocytes in the lower portion of the epidermis and by general epidermal hyperplasia , including hypergranulosis and hyperkeratosis .
C0023005
langerhans
C0014520
epidermis