the mean ( +/- sd ) percent increase in auc ( 0 to 24 hours ) of spironolactone when it was given with food , compared with the ingestion on an empty stomach ( 95.4 % +/- 66.9 % ) , was much more pronounced than the corresponding increase of 7 alpha-thiomethylspirolactone ( 45.4 % +/- 33.7 % ) , 6 beta-hydroxy-7 alpha-thiomethylspiro-lactone ( 21.8 % +/- 21.5 % ) , and canrenone ( 40.7 % +/- 26.3 % ) .
C0037982
spironolactone
C0022947
lactone