pasteurella haemolytica a1 leukotoxin causes rapid ( 5 to 15 min ) leakage of intracellular k+ and cell swelling and slower ( 15 to 60 min ) , ca2+-dependent formation of large plasma membrane defects ( congruent to 100 nm ) and leakage of lactate dehydrogenase from bovine lymphoma cells ( bl3 cells ) ( k. d. clinkenbeard , d. a. mosier , a. l. timko , and a. w. confer , am . j. vet . res. , in press ) .
C0007603
plasma membrane
C0007634
cells