antibody against a cross-reactive idiotype ( cri ) on human igm-rheumatoid factor ( rf ) antibodies was induced by immunization of rabbits with a synthetic peptide ( psl2 ) corresponding to the second complementarity-determining region ( cdr ) , and adjacent amino acid residues of the kappa light chain of the igm-rf sie . the anti-peptide antibody bound efficiently to igm-rf proteins known to share a cross-reactive idiotype , and to their isolated kappa chains .
C0021024
complementarity-determining region
C0021036
kappa light chain