we studied the structure of the insulin-receptor gene in normal individuals and in four unrelated patients with leprechaunism ( minn-1 , ark-1 , ark-2 , can-1 ) and four unrelated patients with the type a syndrome of insulin resistance , both disorders associated with genetic alterations in affinity , binding capacity , and kinase activity of the insulin receptor .
C0971285
ark-1
C0031727
kinase