after binding to its four 9-mer boxes in the 245-base pair escherichia coli replication origin ( oric ) , dnaa protein effects the formation of an `` '' open complex '' '' in an adjacent region made up of three 13-mers ( bramhill , d. , and kornberg , a . ( 1988 ) cell 52 , 743-755 ) .
C0242961
replication origin
C0007634
) ce