in adrenalectomized dogs administered fixed mineralocorticoid and glucocorticoid replacement , spironolactone resulted in a definite renal antimineralocorticoid effect , as evidenced by natriuresis and chloruresis , and sustained metabolic acidosis and hyperkalemia due in part to impaired renal secretion of hydrogen and potassium .
C0037982
spironolactone
C0020461
hyperkalemia