since the human tumors that have been shown to have the most substantial responses to il-2 ( i.e. , malignant melanoma and renal cell carcinoma ) are those long considered to be immunogenic in the autochthonous host , the current study predicts that for these , as well as other immunogenic human tumors , it should be possible to decrease the toxicity and thus increase the therapeutic index of il-2 by selectively depleting nk cells in vivo .
C0086418
human
C0021756
il-2