administration of single oral doses ( 10 , 25 , 50 , or 100 mg/kg ) of the compound to icr mice on day 11 of gestation ( plug day = day 0 ) produced dose-dependent frequencies of serious fetal anomalies of the type usually associated with the use of retinoic acid and other retinoids .
C0032961
gestation
C0040845
retinoic acid