the clinical relevance of changes in pharmacokinetics of oral mexiletine ( 600 mg daily dose ) was studied in 82 patients with ventricular arrhythmias and impaired liver , renal or heart function ( control group n = 51 , patients with liver cirrhosis n = 9 , with renal insufficiency n = 14 , or heart failure n = 8 ) .
C0023884
liver
C0023890
liver