immediately after intravenous infusion of a high dose ( concentration in serum greater than 1000 mumol/l ) of methotrexate , the apparent conjugated bilirubin ( bc ) concentrations in serum of two osteosarcoma patients , as measured by the kodak ektachem 400 analyzer , were greater than the corresponding total bilirubin concentrations , but decreased as the concentrations of methotrexate in serum decreased .
C0029463
osteosarcoma
C0025677
methotrexate