major increases in the content of putrescine ( 330 % ) , spermidine ( 103 % ) , and spermine ( 50 % ) developed at 48-72 h. alpha-difluoromethylornithine ( dfmo ) , a specific irreversible inhibitor of odc , suppressed the evoked increase in odc activity and abolished the associated increase in content of polyamines , findings indicating that the accumulation of polyamines in cryoinjured brain reflects enhanced synthesis resulting from an odc-mediated increase in putrescine content .
C0006104
brain
C0423896
content