possible explanations for this dichotomy in lh response include : ( 1 ) lhrh neurons in unanesthetized , estrogen-treated ovariectomized ( ovx ) rats are relatively unresponsive to ne , ( 2 ) the chloral hydrate anesthesia used in our brain stimulation studies elevates the threshold of excitability of lhrh neurons to norepinephrine ( ne ) and/or pituitary responsiveness to lhrh , ( 3 ) preliminary mpn-ecs reduces thresholds of responsiveness of lhrh neurons to ne , and ( 4 ) the lhrh secreted after mpn-ecs sensitizes the pituitary gland to the subsequent small amounts of lhrh released following lc- or a1-stimulation .
C0032002
pituitary
C0032005
pituitary gland