the rat brain appears to have little capacity to adapt to chronic hyperammonemia because there were no differences in activity compared with those of weight-matched controls for the following brain enzymes involved in glutamate/ammonia metabolism : glutamine synthetase , glutamate dehydrogenase , aspartate aminotransferase , glutamine transaminase , glutaminase , and glutamate decarboxylase .
C0006104
brain
C0017796
glutaminase