using peripheral blood concentration and myocardial content data ( from coronary sinus catheterization and serial determination of transmyocardial drug concentration gradients ) from a previous clinical study of the antiarrhythmic drugs lidocaine and mexiletine , we tested the hypothesis that two prospectively defined models of myocardial drug disposition could be used to predict myocardial drug content , in the first 30 min following bolus iv injection , from peripheral blood concentrations alone .
C0003195
antiarrhythmic
C0025887
mexiletine