the recent reports of the effect of 2,3-diphosphoglycerate ( 2,3-dpg ) on hemoglobin affinity for oxygen suggested that this substance may play a role in man 's adaptation to acidosis and alkalosis.a study of the effect of induced acidosis and alkalosis on the oxyhemoglobin dissociation curve of normal man was therefore carried out , and the mechanisms involved in the physiological regulation of hemoglobin oxygen affinity examined.in acute changes of plasma ph there was no alteration in red cell 2,3-dpg content .
C0019046
hemoglobin
C0014792
red cell