the compound , 2,4-dichlorobenzyl thiocyanate ( dcbt ) was previously shown to cause mitotic arrest , disruption of intracellular microtubules , and inhibition of tubulin polymerization , with resistance to the drug conferred by a mutation in a beta-tubulin gene ( abraham , i. , dion , r.l. , duanmu , c. , gottesman , m.m . and hamel , e. ( 1986 ) proc . natl . acad . sci . usa 83 , 6839-6843 ) .
C0026046
microtubules
C0041348
tubulin