the preparation of a wide variety of 6-substituted trimethoprim analogues was readily accomplished by the reaction of 2,4-diamino-6-substituted-pyrimidines with 2,6-dimethoxy-4- [ ( n , n-dimethylamino ) methyl ] phenol at 120 -- 160 degrees c .
C0041041
trimethoprim
C0034289
pyrimidines