estimation of intramitochondrial ph with [ ( 14 ) c ] 5,5-dimethyl-oxazolidine-2,4-dione showed that the ph gradient across the inner mitochondrial membrane was significantly greater with 10 than with 40 mm bicarbonate in the medium.a hypothesis is described that relates this effect of ph and bicarbonate on mitochondrial anion accumulation to the very rapid changes in substrate levels in renal cortex , which develop when acute metabolic acidosis or alkalosis is produced in the intact animal .
C0230840
inner mitochondrial membrane
C0026237
mitochondrial