aberrant metabolic parameters associated with severe deficiency of hpr transferase activity , i.e . elevated rates of purine excretion , increased accumulation of hypoxanthine , elevated 5-phosphoribosyl-1-pyrophosphate contents , altered nucleoside triphosphate pools , resistance to toxic effects of 6-thioguanine , were partially to nearly completely corrected ;
C0034140
purine
C0039902
thioguanine