among the antiepileptics studied , valproate ( ed50 : 340 mg/kg after subcutaneous injection of nmdla ) and diazepam ( ed50 : 0.78 mg/kg after intravenous and 14 mg/kg after subcutaneous injection of nmdla ) antagonized nmdla-induced convulsions , whereas phenobarbital ( up to 80 mg/kg ) , diphenylhydantoin ( up to 50 mg/kg ) and ethosuximide ( 500 mg/kg ) were totally ineffective .
C0003299
antiepileptics
C0015043
ethosuximide