despite ischemia , these changes in load and nonuniformity during isoproterenol were associated with enhanced diastolic function compared with pacing tachycardia : isoproterenol reduced t 1/2 , the half-time of pressure decline after peak negative dp/dt ( from 46 +/- 10 to 33 +/- 6 msec , p less than 0.001 ) , shifted the diastolic pressure-volume curve downward and rightward in 10 of 12 patients , and increased end-diastolic volume ( from 77 +/- 18 % to 100 +/- 11 % of control values , p less than 0.001 ) with no change in end-diastolic pressure ( 19 +/- 7 to 19 +/- 5 mm hg , p = ns ) .
C0039231
tachycardia
C0022245
isoproterenol