in the absence of exogenous aldosterone , spironolactone ( 16 mg/kg ) was essentially devoid of diuretic activity whereas hydrochlorothiazide ( 1 mg/kg ) induced marked increases in na ( 256 % ) and k ( 105 % ) excretion and urine volume ( 109 % ) .
C2266870
diuretic activity
C0020261
hydrochlorothiazide