it is concluded that 1 ) estradiol in the presence or absence of testosterone decreases total accumulation of vascular connective tissue and alters the proportions of collagen and elastin so that the vessel is more distensible , 2 ) testosterone has an opposite but less marked effect than estradiol on vascular connective tissue , and 3 ) estradiol and testosterone alter blood pressure in opposite directions in the male rat .
C0005847
vessel
C1511228
vascular