in urethane-anesthetized rats , intravenous administration of delta 9-thc ( 1 , 2 and 5 mg/kg ) produced a significant and transient dose-related rise but no fall in blood pressure . delta 9-thc at these doses also produced marked reduction in heart rate which was antagonized by atropine ( 0.5 mg/kg i.v . ) or bilateral vagotomy .
C0428977
reduction
C0004259
atropine