this catalytically active sedimentable fraction from s phase chef/18 cells or actively replicating calf thymus cells contains nascent and template dna , and numerous enzymes required for dna biosynthesis including ribonucleoside diphosphate reductase , thymidylate synthetase , dihydrofolate reductase , dna methylase , topoisomerase and dna polymerase .
C0598312
dna biosynthesis
C1336767
topoisomerase