immediately after the removal of 90 per cent or more of the pancreas , diabetes developed , and the function of the anti-insulin system was depressed , showing a poor response of glucagon secretion to hypoglycemia after insulin load and degeneration or destruction of the islet cells and both a and b cells , and the dosage of insulin required to control blood sugar was close to that of a total pancreatectomy .
C0030274
pancreas
C0022131
islet cells