to determine whether alterations in lipoprotein phospholipid composition might be an unrecognized factor that contributes to the unexplained acceleration of atherogenesis and the loss of sex-related protection from the development of coronary heart disease in women with insulin-dependent diabetes mellitus , we have estimated levels of neutral lipids , apolipoproteins ( a-i , a-ii , b ) , and free cholesterol ( fc ) in plasma and the four major phospholipid constituents of the very low-density lipoprotein + low-density lipoprotein and high-density lipoprotein ( hdl ) fractions in 12 ambulatory female patients with varying degrees of diabetic control .
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