morphological changes in erythrocytic stages of p. berghei following a single oral/sc dose of 25 and 50 mg/kg respectively in rats were at first swollen lacunes of the endoplasmic reticulum and extremely enlarged mitochondrion ( 6 h after treatment ) , then an apparent vacuolisation of the cytoplasm and pyknosis of the nucleus , as well as distinctly enlarged perinuclear space and later marked fissuring of the cytoplasm .
C0026237
mitochondrion
C0010834
cytoplasm