since active tgf beta has powerful inhibitory effects on osteoclast formation and bone resorption and stimulates osteoblast activity , is present in abundant amounts in the bone matrix and is released during hormone-stimulated osteoclastic bone resorption , the activation of tgf beta by stimulated osteoclasts may be an important regulatory step in normal bone remodeling .
C0005962
bone matrix
C0262950
bone