when the total dose of each optical isomer was increased to 50 nmol , ( - ) -diol epoxide-1 was still inactive , and ( + ) -diol epoxide-1 produced a significant number of lung tumors ( 0.9 lung tumor/mouse ) , but this isomer still had less than 10 % of the activity of the ( + ) - and ( - ) -diol epoxide-2 isomers .
C0024109
lung
C0024121
lung tumor