determination of ld50 upon intragastric administration , intravenous administration ( model of rapid penetration into the organism ) , static inhalatory treatment under saturated concentration , determination of the primary local effect of the skin and mucous membranes , together with careful observation of the behaviour of the experimental animals , signs of their intoxication and their death , as well as comparison of the physico-chemical properties of the substance and its already familiar structural analogues may serve as the ground for predicting the biological significance of the new substance even at longer terms of contact with the organism and making toxicological and hygienic assessments under concrete technological conditions .
C0439861
substance
C0005889
biological