after tolazamide administration , both the early phase of glucose-induced insulin secretion ( 56 +/- 52 vs 141 +/- 68 microu/ml . 10 min ) and insulin binding ( 5.9 +/- 0.5 vs 7.0 +/- 0.5 % /1.6 x 10 ( 9 ) cells ) increased in all three nonresistant patients , but there was no consistent improvement in fasting hyperglycemia ( 128 +/- 11 vs 130 +/- 24 mg/dl ) , intravenous glucose tolerance ( kivgtt 0.77 +/- 0.18 vs 0.89 +/- 0.29 % /min ) , or facilitation of glucose disposal by insulin ( km 70 +/- 5 vs 64 +/- 5 microu/ml ; vmax 10.8 +/- 0.6 vs 10.1 +/- 0.2 mg/kg/min ) .
C0020456
hyperglycemia
C0017725
glucose