it has been shown previously that there are two pathways by which the esterified cholesterol formed in human plasma in the reaction catalysed by lecithin : cholesterol acyltransferase may be delivered to very low density lipoproteins ( vldl ) and low density lipoproteins ( ldl ) : ( a ) an indirect pathway in which esterified cholesterol which was incorporated initially into high density lipoproteins ( hdl ) is transferred subsequently to vldl and ldl in a process mediated by an esterified cholesterol transfer/exchange protein and ( b ) a direct pathway in which a small proportion of the esterified cholesterol formed in the lecithin : cholesterol acyltransferase reaction is delivered to vldl and ldl directly from its site of synthesis via a pathway which bypasses the bulk hdl fraction .
C0008377
cholesterol
C0008387
esterified cholesterol