the biochemical mechanism by which sulfonylureas promote the accumulation of fructose 2,6-bisphosphate in hepatocytes seems to be related to a significant increase of the hexose 6-phosphate pool ( glucose 6-phosphate plus fructose 6-phosphate ) , together with the activation of 6-phosphofructo 2-kinase and inactivation of fructose 2,6-bisphosphatase , enzyme activities responsible , respectively , for the synthesis and degradation of fructose 2,6-bisphosphate .
C0019494
hexose
C0016745
fructose