methylglyoxal bis ( guanylhydrazone ) , a cytostatic compound which apparently interferes with the metabolism and/or functions of the natural polyamines ( spermidine and spermine ) , was effectively taken up by cultured human lymphocytic leukemia cells , rapidly resulting in the formation of a concentration gradient of up to 1,000-fold across the cell membrane in cells grown in the presence of micromolar concentrations of the drug .
C0007603
cell membrane
C0007634
cells