in the more advanced stages of the disease , the following nuclear abnormalities were observed in muscle fibres showing an extensive disintegration of myofibrils : 1 ) large dilations of the perinuclear cisternae , 2 ) small nuclear protrusions projecting into these dilations and 3 ) appositions of stray membranes of the disrupted endoplasmic reticulum to the nuclear envelope .
C0230540
perinuclear cisternae
C0028584
nuclear envelope