since beta-adrenergic receptor phosphorylation may be involved in desensitization , we studied agonist-promoted receptor phosphorylation during homologous desensitization in wild-type s49 lymphoma cells ( wt ) and two mutants defective in the camp-dependent pathway of beta-agonist-stimulated protein phosphorylation ( cyc- can not generate camp in response to beta-adrenergic agonists ; kin- lacks camp-dependent kinase ) .
C0031715
phosphorylation
C0031727
kinase