the view that the insulinotropic response to hypoglycemic sulfonylureas is somehow related to an inhibitory action of these drugs on either the ca2+-activated k+ permeability or the na+ , k+-atpase activity in pancreatic islet cells was investigated by measuring the effect of tolbutamide on 86rb outflow and uptake , 45ca outflow , and insulin release in rat pancreatic islets .
C0038766
sulfonylureas
C0040374
tolbutamide