to test whether the increases of odc ( and polyamines ) are necessary to the slower and later induction of th , induction of odc in vivo was undertaken . alpha-difluoromethylornithine ( alpha-dfmo ) , an irreversible inhibitor of odc , given orally or subcutaneously , almost completely abolished the induction of odc by apm or immobilization , and inhibited the increase of putrescine in both cases , but did not affect spermidine after apm .
C0034170
putrescine
C0037871
apm