using in situ hybridization with 35s-labeled antisense and sense neutrophil elastase crna probes , the present study demonstrates that expression of the neutrophil elastase gene is tightly controlled in bone marrow precursors and occurs during a very limited stage of differentiation of the neutrophil myeloid series , almost entirely at the promyelocyte stage .
C0005953
bone marrow
C0033416
promyelocyte