the topical application of demecolcine ( colcemid , n-desacetyl methyl colchicine ) , n-desacetyl thiocolchicine ( thio-colciran ) , and methotrexate preferably in combination , exerts a selectively destructive action on rodent ( basal cell ) carcinomas , solar keratoses , bowen 's disease , and keratoacanthomas , while sparing surrounding normal tissues .
C0011259
demecolcine
C0009262
colchicine