this antiviral drug requires hsv thymidine kinase for phosphorylation to an active inhibitor ( 2'ndg-triphosphate ) , and thymidine kinase-deficient mutants of hsv exhibit varying degrees of resistance to 2'ndg , with the hsv type 1 ( hsv-1 ) b2006 mutant ( kit ) being markedly resistant .
C0031715
phosphorylation
C0040078
thymidine kinase