after 2 years rheumatoid arthritis developed in the mother of the family ( patient 3 ) and another 2 years later the second son ( patient 4 ) was affected by mixed connective tissue disease ( mctd ) with arthritis , raynaud 's phenomenon , aperistalsis of the esophagus and a high titer of antibody to extractable nuclear antigen ( ena ) .
C0003873
rheumatoid arthritis
C0003864
arthritis