enalaprilat ( mk-422 ) , a new and potent angiotensin- converting enzyme inhibitor , and its monoethyl ester precursor , enalapril , were studied in a single pass perfused rat liver preparation under constant perfusate flow ( 10 ml/min ) at concentrations of 0.29-0.41 microm for 14c-enalapril and 0.01-0.015 microm for 3h- enalaprilat . during their simultaneous delivery to the same rat liver preparation , the steady state hepatic extraction ratio of 14c-enalapril was high ( 0.861 +/- 0.02 ) and 14c- enalaprilat appeared rapidly in effluent perfusate plasma .
C0014025
enalapril
C0014027
enalaprilat