since june 1978 , 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate ( hdmtx ) and citrovorum factor rescue ( cfr ) , adriamycin , and the combination of bleomycin , cyclophosphamide and dactinomycin ( bcd ) given for 4-16 weeks prior to definitive surgery .
C0029463
osteogenic sarcoma
C0025677
methotrexate