on the basis of the subcellular distribution of the 3h-df analogues , methylamine inhibition of iron chelation by siderophores in cell cultures and the positive effect of acidic ph and hydrolysis by lysosomal enzymes on in vitro iron mobilization from radiolabelled ferritin , we suggest that iron mobilization by df and its derivatives occurs in lysosomes where they complex iron released from ferritin under the conjugate actions of acidic ph and lysosomal enzymes .
C1517598
iron chelation
C0015879
ferritin