studies on the pathogenesis of alpha 2u-globulin nephropathy have demonstrated that this protein is produced in large amounts in the male rat , that reversible binding occurs between chemicals and/or their metabolites and alpha 2u-globulin , and that this complex is resistant to proteolytic hydrolysis , leading to accumulation in renal lysosomes and subsequent cytotoxicity and cell death .
C0022658
nephropathy
C0022646
renal