the growth and survival of hamster h2t pancreatic ductal adenocarcinoma in vitro are known to be significantly reduced by inhibitors of polyamine biosynthesis . alpha-difluoromethylornithine ( alpha-dfmo ) is a specific and irreversible inhibitor of ornithine decarboxylase , the rate-limiting enzyme in polyamine biosynthesis . alpha-dfmo treatment inhibits the growth of h2t pancreatic cancer cells and decreases h2t cell survival in vitro and in vivo .
C0007634
cells
C0007620
cell survival