to determine the effect of thyroid hormone excess on insulin secretion , metabolism and action in humans , we examined intravenous glucose tolerance , glucose-induced insulin secretion , insulin clearance , monocyte insulin receptor binding , and the dose-response characteristics for the effects of insulin on glucose production , uptake , oxidation , and nonoxidative disposal in 10 normal volunteers for 14 days before and after oral administration of triiodothyronine ( t3 ) in doses that increased plasma t3 to levels observed in spontaneous thyrotoxicosis ( p less than 0.001 ) .
C0041014
triiodothyronine
C0040156
thyrotoxicosis