addition of 20 micrograms/ml of arachidonic acid to an otherwise teratogenic hyperglycemic serum medium ( 950 mg/dl of d-glucose ) prevented the malformations induced by hyperglycemic conditions : open neural tube , advanced neuropil formation in the neuroepithelium , significant reduction of rough endoplasmic reticulum , decreased size and number of lipid droplets , and increased number of lysosome-like structures in the visceral endodermal yolk sac cells .
C0017725
glucose
C0020456
hyperglycemic conditions