when analyzing the effect of substrate concentration on the reaction rate of aminopyrine n-demethylation , aniline p-hydroxylation , and 3,4-benzpyrene hydroxylation by human fetal and adult liver samples we found that lineweaver-burk and eadie-hofstee analyses yielded mostly linear lines with fetal liver , but nonlinear lines with adult livermthis may be taken to indicate that a qualitative change in drug-oxidizing enzymes of the human liver occurs during ontogenetic development , of the human liver occurs during ontogenetic development , possibly so that during the fetal period liver contains one ana during the adult period two enzymes metabolizing aminopyrine , anilinw , and 3,4-benzpyrene .
C0015965
fetal
C1517162
fetal liver