a five-fold administration to wistar rats of crystalline bovine trypsin in a dose of 0.01 mg per 100 g of body weight stimulated formation of rosette forming cells ( rfc ) and antibody forming cells ( afc ) in the spleen in injection of the antigen 2 hours after the termination of trypsin treatment , but failed to influence the immune response in case of immunization 48 hours after the terminal injection of the enzyme .
C0003320
antigen
C0301872
immune response