we show for the first time that a decrease in hydroxyurea resistance is accompanied by a parallel decline in gene copies for the m2 component of ribonucleotide reductase , ornithine decarboxylase and a gene of unknown function called p5-8 , indicating that the co-amplification of the three genes is associated with drug resistance , and supporting the concept that m2 , ornithine decarboxylase and p5-8 are closely linked , and form part of a single amplicon in hamster cells .
C0297817
m2
C0013203
drug resistance