embryos treated on day 9.5 with 1.5 iu l-asparaginase/ml of culture medium exhibited growth and development retardation together with malformations of the brain ( exencephalia ) , eyes ( anophthalmia or rudimentary sulcus opticus ) , face ( characteristic appearance with anomalous frontolateral protrusions ) and trunk ( myeloschisis and turning absence ) .
C0015392
eyes
C0003119
anophthalmia