h1-receptor antagonist , mepyramine ( 5 and 30 mg/kg ip ) and h2-receptor antagonist , cimetidine ( 25-250 microgram ivt ) , being ineffective in changing hi level i the brain when given alone , exhibited a slight tendency , respectively , to increase ( by 30 % ) and to decrease ( by 20 % ) the l-his-induced elevation of hi content in the rat brain .
C0006104
brain
C0423896
content