the likelihood of induction of cancer in a particular organ would depend on three factors : ( 1 ) the initial level of alkylation of dna in that organ , ( 2 ) the rate of removal of o6-alkylguanine from dna and ( 3 ) the extent of dna replication during the critical period in which o6-alkylguanine is present .
C0012854
dna
C0598312
dna replication