granulosa cells of the largest follicle ( f1 ) produced up to ten times more progesterone than cells from smaller follicles ( f3-f5 ) , not only in response to luteinizing hormone ( lh ) , but also when stimulated by exogenous cyclic amp or forskolin , both of which raise intracellular cyclic amp levels by nonreceptor-mediated mechanisms .
C0018207
granulosa cells
C0018120
follicle