the cytotoxic and mutagenic effect of aflatoxin b1-dichloride ( afb1-cl2 ) , a direct-acting carcinogen which is a model for the proposed ultimate reactive metabolite of afb1 ( the 2,3-epoxide ) , was compared in normal , repair-proficient , diploid human fibroblasts and in complementation group a xeroderma pigmentosum cells ( xp12be ) which are virtually incapable of excision repair of dna damage induced by ultraviolet radiation , the 7,8-diol-9,10-epoxide of benzo [ alpha ] pyrene , and several reactive aromatic amide derivatives .
C0016030
fibroblasts
C0007634
cells