these results suggested that plasmin generated from plasminogen by a tumor cell-associated plasminogen activator may be most important for matrix hydrolysis at low cell densities , and while certain tumor cell lines showed a definite plasminogen-independent matrix degradation with increased cell numbers , other neoplastic cells hydrolyzed the matrix only in the presence of the zymogen at all cell densities .
C0032144
plasminogen activator
C0020291
hydrolysis