many of these drugs cause aggravating ocular irritation ( fluorouracil , methotrexate ) , canalicular fibrosis with epiphora ( fluorouracil ) , retinopathy ( mitotane , tamoxifen ) , corneal opacities ( tamoxifen ) , cataracts ( busulfan , methotrexate ) , and optic or ocular motor abnormalities ( carmustine , vinblastine , vincristine ) .
C0035309
retinopathy
C0015392
ocular