neuronally-evoked pressor effects were also antagonized by pindolol ( 50 mug/kg , orally ) .5 whereas pindolol , 50 mug/kg orally or intraperitoneally , produced a marked and progressive hypotensive response of rapid onset ( 20 min ) in ds-rats the same dose intravenously produced a smaller response of delayed onset ( 80 minutes ) .6 in anaesthetized ds-rats , an equivalent degree of cardiac beta-adrenoceptor blockade was produced by pretreatment with pindolol , 50 mug/kg orally ( 2 h previously ) or intravenously ( 1 h previously ) .7 after administration of pindolol , 2 mg/kg intravenously , to conscious ds-rats , the tachycardia produced by intravenous isoprenaline , 3 mug/kg , was almost abolished for the first 60 min of the study , whereas a hypotensive response to pindolol was delayed in onset ( 100 minutes ) .8 the hypotensive response and tachycardia produced by oral pindolol 50 mug/kg , in ds-rats were prevented by inhibition of metabolic enzyme activity by pretreatment with proadifen ( skf 525-a ) , 80 mg/kg.9 the results suggest that pindolol 's effects on blood pressure and heart rate in the conscious ds-rat are mediated by a metabolite ( s ) acting by stimulation of peripheral beta-adrenoceptors .
C0022245
isoprenaline
C0039231
tachycardia