dna samples from numerous subjects of different racial and ethnic backgrounds , with or without various hemoglobinopathies ( classical beta-thalassemia ; silent beta-thalassemia , hb e , sickle cell anemia ) , were studied for a rearrangement ( +ata ; -t ) at nucleotide -530 in the 5 ' flanking region of the beta-globin gene using amplified dna and 32p-labeled synthetic oligonucleotide probes .
C0019045
hemoglobinopathies
C0002895
sickle cell anemia