in contrast , indomethacin was 20 times as potent as n-0164 as an inhibitor of prostaglandin endoperoxide formation from arachidonic acid ( ic ( 50 ) 2.6 x 10 ( -5 ) m or 9.4 mug/ml ) .3 spiral strips of dog coronary arteries relaxed in the presence of prostaglandin endoperoxides and were contracted by prostaglandin e ( 2 ) and thromboxane-a ( 2 ) and were therefore used to distinguish between prostaglandins and their intermediate precursors , the endoperoxides.4 neither indomethacin nor n-0164 ( both 50 mug/ml ) significantly inhibited the formation of prostaglandin-like activity from the endoperoxides following incubation with indomethacin-pretreated rabbit kidney medulla microsomes.5 it is not known whether this action of n-0164 is related to its ability to antagonize certain actions of prostaglandins ( and related compounds ) or whether n-0164 can penetrate the cell membrane to inhibit thromboxane formation in the intact cell.6 selective inhibition of thromboxane formation by drugs such as n-0164 may be useful both clinically and as a pharmacological tool to elucidate the patho-physiological roles of the thromboxanes .
C0033559
prostaglandin e
C0033554
prostaglandins