these concentrations of ryanodine are approximately three orders of magnitude higher than those required to saturate binding of the alkaloid to the ryanodine receptor of sarcoplasmic reticulum and to open the calcium release channel of sarcoplasmic reticulum ( i.e . 20 nm ( 1988 ) j. gen. physiol . 92 , 1-26 ) .
C0035983
ryanodine
C0002062
alkaloid