in support of this hypothesis , we here show that inhibition of polyamine biosynthesis with alpha-difluoromethyl-ornithine ( dfmo ) blocks the mitogenic effect of estradiol-17 beta ( e2 ) added to nmu-mammary tumors grown in soft agar in the presence of the antiestrogen tamoxifen ( tam ) .
C1514195
inhibition
C0002260
alpha-difluoromethyl-ornithine