the high molar ratio of plasma gamma anp- ( 1-25 ) -li to alpha anp-li ( 17.4 +/- 1.4 ) in normal subjects and the significantly higher ratio in patients with chronic renal failure ( 36.9 +/- 7.1 ; p less than 0.01 ) suggest the slower clearance of the n-terminal gamma anp fragment than alpha anp and a role for the kidney in its degradation .
C0022661
chronic renal failure
C0022646
kidney