both desaturase activities were depressed by a soluble factor present in the cytosolic fraction of cells , since the supernatant of microsomes separated at 110,000 x g from hormonal-treated rat liver homogenates , added to crude or washed control microsomes , was able to inhibit in vitro linoleic and homo-gamma-linolenic conversion to gamma-linolenic and arachidonic acids , respectively .
C1383501
cytosolic
C0007634
cells