we have measured classic markers of bone turnover , serum alkaline phosphatase ( sap ) , urinary hydroxyproline/creatinine ratio ( uoh-prol/creatinine ) and osteocalcin ( sbgp ) , in two bone disorders characterized by an increase in bone remodelling , namely paget 's disease of bone and primary hyperparathyroidism ( phpt ) and in two other bone diseases characterized by an increase in bone resorption without the concomitant increase in bone formation , hypercalcaemia of malignancy ( hm ) and involutional osteoporosis ( io ) .
C0029401
paget 's disease of bone
C0005940
bone diseases