we describe an improved `` '' high-pressure '' '' liquid-chromatographic assay for simultaneous determination in serum of the five major antiepileptic drugs ( ethosuximide , primidone , phenobarbital , phenytoin , and carbamazepine ) and n-desmethylmethsuximide ( the compound that must be quantitated for therapeutic drug monitoring of the antiepileptic drug methsuximide ) .
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