we report 11 preterm infants ( gestational age 25-33 week ) treated with digoxin for pda in whom a standard indomethacin therapy ( mean of total dose = 0.32 mg/kg ) resulted in a significant elevation of serum digoxin to potentially toxic levels ( from 2.2 +/- 0.7 ng/ml to 3.2 +/- 0.7 ) ( p less than 0.001 ) .
C0013274
pda
C0021246
indomethacin