pretreatment of rats with tricyclic antidepressants , imipramine , desipramine , amitriptyline and nortriptyline , at two doses ( 5 and 25 mg/kg ) 20 minutes before administration of barbiturate markedly reduced the latent period of the response to barbital and prolonged the sleeping time induced by pentobarbital ( pb ) and barbital .
C0004745
barbiturate
C0004743
barbital