degenerative changes as seen by electron microscopy in malignant cells treated with hematoporphyrin and white light consist of a ) swelling and disruption of mitochondria , b ) early loss of cytoplasmic projections , c ) formation of localized zone of new cytoplasmic projection which then detach from cell surface , and d ) nuclear degeneration occurs late as a last event .
C0026237
mitochondria
C0010834
cytoplasmic