on the other hand , mapa-orn and apa-orn were both more potent than the corresponding glu derivatives mtx and amt against l1210/r81 cells , suggesting that in these mtx-resistant cells there may occur a `` '' self-potentiation '' '' process involving enhanced antifolate activity via interference with the polyglutamylation of reduced folates .
C0002583
amt
C0025677
mtx