the identity of the kinase that phosphorylates acycloguanosine was determined after separation of the cellular and virus-specified thymidine kinase activities by affinity chromatography , by reversal studies with thymidine , and by the lack of monophosphate formation in a temperature-sensitive , thymidine kinase-deficient mutant of the kos strain of herpes simplex virus type 1 ( tsa1 ) .
C0031727
kinase
C0040078
thymidine kinase