studies of methylation along 28 kilobases of x-chromosome dna , assayed by southern blot analysis using cloned x-chromosome-specific probes , indicates that x dna methylation in normal human cells changes with replication , is not correlated with number of x chromosomes or transcriptional activity , and is less stable and more prevalent than when the human x is in the foreign environment of mouse-human hybrid cells .
C0012854
dna
C0598312
replication