a combination of nuclear inclusions , invaginations of the nuclear membrane , a reduction of the number of mitochondria with a simultaneous increase in size to the point of development of megamitochondria , a disorganization of the endoplasmic reticulum and a decrease of its surface density , an increase of the lysosomal volume share and a lipofucin accumulation indicates the existance of an aged cell .
C0028584
nuclear membrane
C0007634
the