male mice were given subdiabetogenic intraperitoneal injections of sz ( 40 mg/kg b.w . ) on five days running. -- the simultaneously performed metabolic , light and electron microscopical , histochemical , fluorescence microscopical , and morphometric examinations show that the small doses of sz lead to a metabolic disturbance in the islets of langerhans already on the third day of the experiment ( after the first two sz injections ) which is associated with a high-degree reduction or an interruption of the insulin production .
C0022131
islets of langerhans
C0021641
insulin