wy-45,086 and wy-45,253 , synthesized as potential antiulcer agents , were shown by in vitro and in vivo evaluation to have potent h2-receptor antagonist activity ( respective pa2 's of 8.1 and 7.6 ) , and to have gastric acid antisecretory activity ( respective ed50 's of 1 and 2 mg/kg in the pylorus-ligated rat and of 1 and 1.4 mg/kg in dogs prepared with innervated gastric pouches ) .
C0034196
pylorus
C0038351
gastric