in man ( n = 5 ) , a single oral 400-mg dose of r 68 070 produces deep and protracted inhibition of platelet txa2 synthetase activity ( greater than or equal to 90 % for 48 h ) , increases serum levels of immunoreactive 6-keto-pgf1 alpha , reduces platelet aggregation in p.r.p . induced by u 46619 , collagen ( greater than 70 % for 8 h ) , arachidonic acid ( greater than 90 % for 18 h ) and prolongs template bleeding times significantly , without affecting plasma coagulation or fibrinolysis .
C0229671
serum
C0032105
plasma