the injections of the heparin-urea complex with a simultaneous blocking of the vegetative nerves system created an anticoagulant and fibrinolytic background in the organism of these animals and produced an antitumorigenic effect , i.e . the inhibition of growth of primary tumors and metastases , the mitotic activity decline in the malignant tissue and a change in the submicroscopic structure of the sarcoma 45 cells ( greater chromatin density , prevalence of the fibrillar component in the nuclei , swelling of the reticulum channels , condensation of mitochondria and reduction of polysomes ) .
C0008546
chromatin
C0007610
nuclei