the african tree combretum caffrum ( combretacae ) has been found to contain a powerful inhibitor of tubulin polymerization ( ic50 2-3 microm ) , the growth of murine lymphocytic leukemia ( l 1210 and p 388 with ed50 approximately 0.003 microm and human colon cancer cell lines [ ( e.g . lovo ( ed50 = 0.005 microgram/ml ) , ht 29 ( ed50 0.02 microgram/ml , colo 205 ( ed50 = 0.07 microgram/ml ) , dld-1 ( ed50 = 0.005 microgram/ml ) and hct-15 ( ed50 = 0.0009 microgram/ml ] designated combretastatin a-4 ( 1c ) .
C0007102
colon cancer
C0009368
colo