using the method of gaba-stimulated 36cl-uptake by rat cerebral cortical vesicles , we show that some antidepressant drugs ( imipramine , amitryptyline , and mianserine ) can inhibit the gaba-receptor chloride uptake , and that the degree of chloride channel inhibition by these drugs correlates with the frequency of convulsive seizures induced by them .
C0003289
antidepressant drugs
C0002600
amitryptyline