the administration of 500 mg/kg/day of ethosuximide for 1 , 2 , 4 , 6 , 8 and 11 days induced neurotoxicity in 100 , 100 , 67 , 0 , 0 and 0 % of animals , respectively , and increased brain gaba concentration 46 , 38 , 25 , 14 , 9 and 0 % , respectively .
C0006104
brain
C0086045
concentration