for example , the dicovery of prostacyclin and the realization that this prostaglandin and not pge2 is the primary metabolite of arachidonic acid in blood vessels emphasizes the need to reinterpret many of the previously held hypotheses that proposed that prostaglandins of the e series contributed to the regulation of vessel tone and blood pressure , moreover , the contribution made by abnormal prostaglandin mechanisms to hypertensive disease should now take into account that a deficiency of prostacyclin and not pge2 could be a major factor causing the elevated tension developed in vascular smooth muscle and the augmented vessel responsiveness to stimuli associated with hypertension .
C0033559
prostaglandins
C0012472
pge2