to assess the effects of intrarenal thromboxane a2 generation on furosemide-induced sodium and water excretion we administered furosemide ( 40 mg i.v . ) to 8 nonazotemic cirrhotic patients with ascites and 8 healthy subjects before and after the administration of oky 046 ( 200 mg twice orally ) , a powerful thromboxane-synthase inhibitor .
C0016860
furosemide
C0003962
ascites