based upon the studies of the neonatal lupus infants , it has been hypothesized that the u1rnp and ro ( ss-a ) autoantibodies of maternal origin play a direct pathologic role in the genesis of the annular polycyclic scle lesions and this may be mediated by antibody-dependent cellular cytotoxicity mechanisms in which the antibody binds to the respective antigen present on the keratinocyte plasma membrane and the effector cells are t cells derived from the infants .
C0003272
antibody-dependent cellular cytotoxicity
C0003320
antigen