incubation of rat fat pad membranes with 5-guanylyliminodiphosphonate [ gpp- ( nh ) p ] and 5-guanylylmethylenediphosphonate [ gpp ( ch2 ) p ] , but not gtp ( with or without hormones ) , at 24 degrees or 30 degrees ( but not at 4 degrees ) greatly stimulates adenylate cyclase activity [ atp pyrophosphate-lyase ( cyclizing ) , ec 4.6.1.1 ] measured after thoroughly washing the membranes .
C0018366
gpp
C0018353
gtp