despite use of a high dosage regimen , such as has evoked intolerable side effects in a high percentage of patients with rheumatoid arthritis , we have experienced few side effects in a total of 48 patients suffering from diseases with auto-immune components , a finding we speculate is due to replacement of nutrients inactivated or removed by d-penicillamine , and to supplementation with selected nutrients .
C0003873
rheumatoid arthritis
C0030817
penicillamine