the iron chelating properties of picolinic acid , and the similarities of its effects on cultured cells to those of hydroxyurea and the iron-chelating drug desferrioxamine , suggest that picolinic acid inhibits dna synthesis by interfering with the iron-dependent production of a stable free organic radical which is essential for the ribonucleotide reductase formation of deoxyribonucleotides .
C0598312
dna synthesis
C0035547
ribonucleotide reductase