co-microinjection of single linearized molecules of plasmids containing the human beta-globin gene ( prk1 ) and the herpes simplex virus ( hsv ) type i thymidine kinase gene ( px1 ) into the mouse tk-l cell nucleus results in covalent linkage between these ( or derived ) molecules within the nucleus as revealed by southern blotting , plasmid rescue , and recovery of plasmid-derived dna from a charon 4a phage library of cellular dna .
C0007610
nucleus
C0007634
cellular