the mean features of the modified platelet profile in hypertension include an increased alpha 2-adrenergic receptor density , an enhanced rate of adhesion/aggregation in particular in response to adp and arachidonic acid , a greater sensitivity for thrombin and adrenaline to stimulate increases in cytoplasmic-free ca2+ , increased resting levels of cytoplasmatic-free ca2+ , a reduced content of serotonin often combined with a defective uptake mechanism , a facilitated efflux rate of noradrenaline , an exaggerated release reaction in vivo as indicated by the increased plasma levels of beta-thromboglobulin and a shortened platelet life span .
C0014563
adrenaline
C0028351
noradrenaline