determination of the rate of plasma clearance , half-life , and volume of distribution of amikacin in 10 patients with normal renal function , four patients undergoing dialysis , and five patients with end-stage renal diseases have shown a relation of half-life ( t1/2 in hr ) to rate of clearance of serum creatinine ( cer ) of t1/2 = 3 x cer , the same relation as found for kanamycin and gentamicin .
C0002499
amikacin
C0022487
kanamycin