treatment of hl-60 promyelocytic leukemia cells with the tumor-promoting phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , causes rapid phosphorylation and dephosphorylation of pp17 , a 17-20-kda , pi 5.5 cytosolic protein , as an early event in a response sequence leading to growth arrest and terminal differentiation into monocytes ( feuerstein , n. , and cooper , h. l. , ( 1984 ) j. biol . chem . 259 , 2782-2788 ) .
C0031586
phorbol
C0039654
12-o-tetradecanoylphorbol-13-acetate