in cultured human fibroblasts we observed that monensin , a na+/h+-exchanging ionophore , ( i ) inhibits mannose 6-phosphate-sensitive endocytosis of a lysosomal enzyme , ( ii ) enhances secretion of the precursor of cathepsin d , while inhibiting secretion of the precursors of beta-hexosaminidase , ( iii ) induces secretion of mature beta-hexosaminidase and mature cathepsin d , and ( iv ) inhibits carbohydrate processing in and proteolytic maturation of the precursors remaining within the cells ;
C0086418
human
C0007427
cathepsin d