we have found two advantages for the concurrent use of solid-phase edman degradation during an extended solid-phase synthesis : ( 1 ) on the basis of the level of error due to incomplete incorporation of amino acids , the solid-phase assembly could be terminated in favor of restarting the synthesis , hence avoiding further work on a defective product and ( 2 ) direct verification of incorporation of amino acids , which during acid hydrolysis are destroyed ( cys , trp ) or are deamidated ( asn , gln ) , is possible by high-pressure liquid chromatography of the corresponding pth derivatives .
C0002520
amino acids
C0017797
gln