using experimental models of parkinsonism , imitating the hypertonus of the parasympathetic system ( hypokinesia , rigidity and tremor ) following the intraperitoneal injection of the acetylcholinesterase inhibitor galanthamin ( 15 mg/kg ) to mice , the authors showed that the m-cholinoblocker metamisyl ( 2 mg/kg ) blocks all manifestations of the cns parasympathetic hypertonus whereas the n-cholinoblocker eterofen ( 30 mg/kg ) increases them .
C0026837
rigidity
C0026826
hypertonus