temperature downshift experiments using chick embryo cells infected with transformation-defective temperature-sensitive viral mutants have shown two major morphological changes occurring at different times in the transformation process : ruffle-like flowers appear on the dorsal cell surface as early as 15 min after temperature shift , while later , between 6 and 12 hr , cytoskeletal stress fibers disappear and the cells round up .
C0010853
cytoskeletal
C0007634
cells