in nine patients with severe head injury subjected to continuous hyperventilation and barbiturate coma treatment with pentobarbitone , the regional cerebral blood flow was measured as initial slope index ( isi ) with a 32 channel cerebrograph , and cerebral metabolic rate of oxygen ( cmro2 ) was calculated as the product of mean global cbf and the arterio-venous oxygen content difference .
C0004745
barbiturate
C0030883
pentobarbitone