three nitrosourea analogs , 1,3-bis ( 2-chloroethyl ) -1-nitrosourea , 1- ( 2-chloroethyl ) -3-cyclohexyl-1-nitrosourea , and 1-trans- ( 2-chloroethyl ) -3-cyclohexyl-1- ( 4-methylcyclohexyl ) -1-nitrosourea , were examined for effects on survival and cell cycle traverse capacity in exponentially growing ( cycling ) populations of line cho chinese hamster cells and in cultures arrested in g1 by isoleucine deprivation during treatment with drugs , then returned to the cycling mode by restoration of isoleucine ( noncycling cells ) .
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arrested
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cells