with the use of kinetic principles , a diazoxide dose regimen ( average load , 7.5 mg/kg at 7.5 mg/min ; average maintenance , 10 % of loading dose every 6 hours ) produced gradual and predictable reductions in map in patients with accelerated hypertension , since the response was proportional to plasma diazoxide concentrations .
C0020540
accelerated hypertension
C0012022
diazoxide