in this nonrestorative sleep disorder , pain and mood symptoms may be mediated by psychologic distress ( e.g. , following a nonphysically injurious industrial or automobile accident ) , noxious environmental stimuli ( e.g. , noise ) , physiologic disturbance ( e.g. , sleep-related myoclonus , painful inflamed joints , i.e. , rheumatoid arthritis ) , and altered central nervous system metabolism ( e.g. , disordered brain serotoninergic functions ) .
C0030193
pain
C0003862
painful