interferon-gamma ( ifn-gamma ) is most likely involved in the mechanisms leading to such an increased cytolytic and oxidative activity , since in vitro experiments showed : 1 ) that less ifn-gamma was required to induce tumoricidal activity in macrophages from infected as compared to macrophages from uninfected animals , 2 ) that the activity of ( 2'-5 ' ) -adenylate synthetase ( 2'-5 ' a-synthetase ) , an enzyme strongly induced by ifn , was elevated in cells from livers of s. mansoni-infected mice .
C1536403
cytolytic
C0007634
cells