when in addition they had been given 400 mg/kg of a thiol drug , namely either penicillamine or its disulphide , or n-acetylcysteine ( nac ) or its s-carboxymethyl derivative carbocysteine , the increase in bladder weight and the histologic changes of haemorrhagic cystitis were found to be prevented by the co-administration of penicillamine or nac but not by penicillamine disulphide or carbocysteine .
C0005682
bladder
C0085692
haemorrhagic cystitis