to determine whether the increase in colony number reflects the interactions of these factors on the same hematopoietic progenitor target cells or , instead , represents activation of accessory cells , we analyzed the effect of il-6 on the proliferation and differentiation of three growth factor-dependent leukemic cell lines that respond with continuous proliferation to the presence of gm-csf and il-3 in culture .
C0007589
differentiation
C0079460
gm-csf