important alterations in the plasma protein binding of phenytoin may occur in the perinatal period , in late pregnancy , in hepatic disease , in renal failure , in the nephrotic syndrome and other conditions associated with hypoalbuminemia , and in the presence of displacing agents such as valproic acid , phenylbutazone , and salicylic acid .
C0023895
hepatic disease
C0042291
valproic acid