control of hypertension ( ie , reduction of blood pressure to less than or equal to 160/90 mmhg ) in 40 mild to moderate hypertensives not responding adequately to hydrochlorothiazide was achieved by the addition of guanfacine ( once daily ) or methyldopa ( twice daily ) in a 16-week , double-blind , parallel-group trial .
C0020538
hypertension
C0020261
hydrochlorothiazide