we have also uncovered major differences in the behavior of carboxy- and amino-terminal alpha-helical mutants which do perturb the cytoskeletal network of ifs : whereas carboxy terminal mutants give rise to aggregates of keratin in the cytoplasm , amino-terminal mutants tend to produce aggregates of keratins which seem to localize at the nuclear surface .
C0010853
cytoskeletal
C0010834
cytoplasm