the plasma membrane receptor is a large transmembrane glycoprotein of 170,000 da containing four domains : an extracellular egf-binding portion , a hydrophobic membrane-spanning segment , a proximal cytoplasmic domain which binds atp and protein substrates containing tyrosine for phosphorylation and a terminal cytoplasmic portion with 3 tyrosines which undergo autophosphorylation after egf binding .
C1511625
cytoplasmic domain
C0010834
cytoplasmic