until the advent of biochemical predictors of unqualified reliability for the identification of the crucial time of invasion , we recommend radical cystectomy for cure of in situ carcinoma provided the patient is a reasonable surgical risk , is severely symptomatic , has histologic evidence of extension of the lesion into the vesical neck , urethra , or terminal ureter , and has either histologic or cytologic persistence of cancer after a 6 to 12 month course of intravesical chemotherapy .
C0194401
radical cystectomy
C0041951
ureter