similarly , a decrease in plasma clearance in cirrhosis ( 7.7 +/- 2.1 compared to 15.3 +/- 4.4 ml per min , p less than 0.01 ) and acute viral hepatitis ( 6.1 +/- 4.3 compared to 18.1 +/- 7.1 ml per min , p less than 0.01 ) relative to age-matched controls and an increase in the volume of distribution resulted in a prolongation of the elimination half-life in both forms of liver disease .
C0023890
cirrhosis
C0023895
of liver disease