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the higher affinity of oil red stain for vldl- than for ldl-immunoprecipitation zones is peculiar to this lipoprotein class , and crossed immunoelectrophoretograms may thus be helpful for laboratory diagnosis of types iib and iv in problematic cases .
NA
{ "id": "C0023825", "name": "vldl", "pos": [ 41, 45 ] }
{ "id": "C0023820", "name": "lipoprotein", "pos": [ 106, 117 ] }
however , the molar enzyme is more susceptible to heat denaturation , presumably due to the presence of a higher level of the heat-labile isoenzyme form a in this tissue .
NA
{ "id": "C0014442", "name": "enzyme", "pos": [ 20, 26 ] }
{ "id": "C0022173", "name": "isoenzyme", "pos": [ 138, 147 ] }
serially cultured fibroblasts from gouty overproducers of uric acid displayed increased purine enzyme levels with increasing cell passage while fibroblasts from normal donors showed little change in activity .
NA
{ "id": "C0007634", "name": "cell", "pos": [ 125, 129 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 144, 155 ] }
to avoid cl restriction in 6 patients with crf ( ccr 10-15 ml/min ) on an estimated 10 meq na and cl diet , electrolyte ex was compared on nacl supplements of 200 meq/day versus a daily mixture of nahco3 ( 100meq ) and nacl ( 100 meq ) .
NA
{ "id": "C0008203", "name": "cl", "pos": [ 9, 11 ] }
{ "id": "C0037494", "name": "nacl", "pos": [ 219, 223 ] }
mean +/- sem ex of na , cl , hco3 meq/day and ccr and deltawt ( lbs ) are compared below for the 4th day of nacl vs nahco3 intake .
NA
{ "id": "C0008203", "name": "cl", "pos": [ 24, 26 ] }
{ "id": "C0037494", "name": "nacl", "pos": [ 108, 112 ] }
mean +/- sem ex of na , cl , hco3 meq/day and ccr and deltawt ( lbs ) are compared below for the 4th day of nacl vs nahco3 intake .
NA
{ "id": "C0005367", "name": "hco3", "pos": [ 29, 33 ] }
{ "id": "C0074722", "name": "nahco3", "pos": [ 116, 122 ] }
greater na ex on nahco3 may depend on severe cl restriction and/or higher serum hco3 levels .
NA
{ "id": "C0074722", "name": "nahco3", "pos": [ 17, 23 ] }
{ "id": "C0005367", "name": "hco3", "pos": [ 80, 84 ] }
plasma elimination curves for methadone , laam , and its metabolites , noracetylmethadol ( n-laam ) and dinoracetylmethadol ( dn-laam ) , were determined after acute and chronic administration .
NA
{ "id": "C0025605", "name": "methadone", "pos": [ 30, 39 ] }
{ "id": "C0025607", "name": "laam", "pos": [ 129, 133 ] }
a double-blind clinical trial was conducted in a non-fluoridated community to determine the effect on enamel fluoride and caries experience of daily rinsing in school with 1,000 parts/10 ( 6 ) solutions of ammonium fluoride or sodium fluoride at ph 4.4 .
NA
{ "id": "C0016327", "name": "fluoride", "pos": [ 109, 117 ] }
{ "id": "C0037508", "name": "sodium", "pos": [ 227, 233 ] }
enamel fluoride levels at the end of 2 years were 3,124 parts/10 ( 6 ) ( ammonium fluoride ) , 2,771 parts/10 ( 6 ) ( sodium fluoride ) , and 2,603 parts/10 ( 6 ) ( placebo ) , p = 0.025 .
NA
{ "id": "C0016327", "name": "fluoride", "pos": [ 7, 15 ] }
{ "id": "C0037508", "name": "sodium fluoride", "pos": [ 118, 133 ] }
tests for opsonic activity , long chain formation , and precipitins were investigated for ability to detect antibodies to the antiphagocytic factor of group e streptococci .
NA
{ "id": "C0032936", "name": "precipitins", "pos": [ 56, 67 ] }
{ "id": "C0003241", "name": "antibodies", "pos": [ 108, 118 ] }
forty strains of bacteroides sp . were tested against three nitroimidazole compounds , metronidazole , tinidazole and nimorazole and the aminoglycosidic antibiotic spectinomycin .
NA
{ "id": "C0028179", "name": "nitroimidazole", "pos": [ 60, 74 ] }
{ "id": "C0025872", "name": "metronidazole", "pos": [ 87, 100 ] }
forty strains of bacteroides sp . were tested against three nitroimidazole compounds , metronidazole , tinidazole and nimorazole and the aminoglycosidic antibiotic spectinomycin .
NA
{ "id": "C0028179", "name": "nitroimidazole", "pos": [ 60, 74 ] }
{ "id": "C0028095", "name": "nimorazole", "pos": [ 118, 128 ] }
nevertheless , this last group of strains , with the exception of one pseudomonas , proved to be sensitive to the association of fosfomycin with a beta-lactamin ( carbenicillin , amoxycillin ) or an aminoglycoside ( gentamicin , tobramycin ) .
NA
{ "id": "C0002556", "name": "aminoglycoside", "pos": [ 199, 213 ] }
{ "id": "C0017436", "name": "gentamicin", "pos": [ 216, 226 ] }
of a total of 45 cases , 34 were exclusively treated with fosfomycin ( 2 g by the intramuscular route and 2 g by the oral route ) and 11 cases were treated with a double association of fosfomycin with a beta-lactamin ( carbenicillin or amoxycillin ) or an aminoglycoside ( gentamicin ) , after having studied the bactericidal activity of the association in vitro .
NA
{ "id": "C0002556", "name": "aminoglycoside", "pos": [ 256, 270 ] }
{ "id": "C0017436", "name": "gentamicin", "pos": [ 273, 283 ] }
the minimum inhibitory concentrations were determined in 98 strains of anaerobic bacteria that came from clinical samples against fosfomycin , penicillin , cephalothin , tetracycline , chloramphenicol , clindamycin and lincomycin .
NA
{ "id": "C0008947", "name": "clindamycin", "pos": [ 203, 214 ] }
{ "id": "C0023726", "name": "lincomycin", "pos": [ 219, 229 ] }
the results obtained indicate that fosfomycin is usually inactive against bacteroides sp . and is active up to 32 mug/ml or less against 85 % of peptococcus and 95 % of peptostreptococcus , being consequently comparatively less active than the rest of the antibiotics that were tested against bacteroides , sp. , while against peptococcus and peptostreptococcus it is less active than penicillin , cephalothin , clindamycin and lincomycin , and somewhat more active than chloramphenicol and tetracycline .
NA
{ "id": "C0008947", "name": "clindamycin", "pos": [ 412, 423 ] }
{ "id": "C0023726", "name": "lincomycin", "pos": [ 428, 438 ] }
it was striking that the su-sensitive n. gonorrheoeae strains showed no potentiation of su by tr when a su/tr ratio of 5:1 is used .
NA
{ "id": "C0038689", "name": "su", "pos": [ 25, 27 ] }
{ "id": "C0041044", "name": "su/tr", "pos": [ 104, 109 ] }
a total of 1109 determinations of digoxin concentration in serum were performed in 317 patients with cardiac failure during oral maintenance therapy with digoxin , beta-acetyldigoxin and beta-methyldigoxin .
NA
{ "id": "C0012265", "name": "digoxin", "pos": [ 34, 41 ] }
{ "id": "C0025132", "name": "beta-methyldigoxin", "pos": [ 187, 205 ] }
the daily doses recommended for oral maintenance therapy are 4mug/kg for beta-methyldigoxin , 5 mug/kg for beta-acetyldigoxin , and 8 mug/kg for digoxin .
NA
{ "id": "C0025132", "name": "beta-methyldigoxin", "pos": [ 73, 91 ] }
{ "id": "C0012265", "name": "digoxin", "pos": [ 145, 152 ] }
it acts by combining with plasma antithrombin , thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors .
NA
{ "id": "C0040018", "name": "thrombin", "pos": [ 37, 45 ] }
{ "id": "C0005789", "name": "coagulation factors", "pos": [ 120, 139 ] }
catecholamine levels in hypophysial portal plasma were determined in pregnant and non-pregnant female rats as well as in intact and castrated male rats , using a radioenzymatic assay for the simultaneous determination of dopamine , norepinephrine , and epinephrine in 50 mul of plasma .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 232, 246 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 253, 264 ] }
dopamine levels in arterial plasma from the same rats were low or undetectable ( 0.4 -- 0.8 ng/ml1 . norepinephrine and epinephrine was undetectable ( less than 0.6 ng/ml ) in portal as well as arterial plasma from these rats . the major catecholamine in extracts of the hypothalamus from pregnant rats was norepinephrine , whereas that in the posterior pituitary was dopamine . dopamine levels in portal plasma collected during proestrus , estrus , diestrus 1 , and diestrus 2 , were 1.32 +/- 0.21 ( mean +/- se ) , 3.87 +/- 0.96 , 3.11 +/- 0.73 , and 2.3 +/- 0.45 , respectively . dopamine in portal plasma from intact and from castrated male rats was approximately 0.6 ng/ml . norepinephrine and epinephrine were not detectable in either portal or arterial plasma from these animals . it is concluded 1 ) that dopamine is secreted into hypophysial portal blood in significant quantities during pregnancy , 2 ) that hypothalamic secretion of dopamine in cyclic rats is greatest during the day of estrus and early diestrus and at least on the day of proestrus , and 3 ) that these findings support the view that dopamine of hypothalamic origin may have an important role in the regulation of anterior pituitary function .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 101, 115 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 699, 710 ] }
moreover , progesterone production by mid-luteal phase cells was consistently stimulated ( p less than 0.01 ) by the presence of 100 ng hcg/ml , whereas late luteal phase cells were less sensitive or unresponsive to exogenous gonadotropin .
NA
{ "id": "C0018062", "name": "hcg", "pos": [ 136, 139 ] }
{ "id": "C0018061", "name": "gonadotropin", "pos": [ 226, 238 ] }
changes in the content of calcitonin in plasma and ultimobranchial glands of chicks during embryonic development were measured using a radioimmunoassay for salmon calcitonin that readily detects chicken calcitonin .
NA
{ "id": "C0073994", "name": "salmon calcitonin", "pos": [ 156, 173 ] }
{ "id": "C0006668", "name": "calcitonin", "pos": [ 203, 213 ] }
rat [ 125i ] sm was displaced by hsmc and rsm and human nsila-s , partially displaced by procine proinsulin and poorly displaced by rat insulin .
NA
{ "id": "C0033362", "name": "proinsulin", "pos": [ 97, 107 ] }
{ "id": "C0021641", "name": "insulin", "pos": [ 136, 143 ] }
1-methyl-3-isobutylxanthine and theophylline blocked the activation by cyclic gmp of cyclic gmp of cyclic amp hydrolysis , whereas ro 20-1724 ( 4- ( 3-butoxy-4-methoxybenzyl ) -2-imidazolidinone ) , a non-methylxanthine inhibitor of phosphodiesterases , did not alter this effect .
NA
{ "id": "C0000096", "name": "1-methyl-3-isobutylxanthine", "pos": [ 0, 27 ] }
{ "id": "C0039771", "name": "theophylline", "pos": [ 32, 44 ] }
this inhibitory effect of carbamoylcholine was blocked by theophylline and 1-methyl-3-isobutylxanthine , but not by ro 20-1724 .
NA
{ "id": "C0039771", "name": "theophylline", "pos": [ 58, 70 ] }
{ "id": "C0000096", "name": "1-methyl-3-isobutylxanthine", "pos": [ 75, 102 ] }
the importance of the tyrosyl residues of lutropin alpha ( as opposed to those of lutropin beta ) is also supported by the similarity of the effect of alkali on the cd spectra of lutropin and lutropin alpha .
NA
{ "id": "C0065261", "name": "lutropin beta", "pos": [ 82, 95 ] }
{ "id": "C0023607", "name": "lutropin", "pos": [ 192, 200 ] }
further evidence for this involvement was also obtained by a comparison of the alkali-induced changes of refolded lutropin ( alpha + beta recombinant ) and the product obtained by recombination of des- ( 92 -- 96 ) -lutropin alpha ( obtained from carboxypeptidase treatment of the alpha-subunit ) and lutropin beta .
NA
{ "id": "C0023607", "name": "lutropin", "pos": [ 114, 122 ] }
{ "id": "C0065261", "name": "lutropin beta", "pos": [ 301, 314 ] }
analysis of the ribosomal proteins with two-dimensional electrophoresis revealed that of the 29 proteins identified in the small subunit , only protein s6 was phosphorylated .
NA
{ "id": "C0035552", "name": "ribosomal proteins", "pos": [ 16, 34 ] }
{ "id": "C0033684", "name": "protein", "pos": [ 144, 151 ] }
the codon properties of a nucleic acid base in messenger rna can be predicted on the basis of its specificity in polynucleotide interactions .
NA
{ "id": "C0009221", "name": "codon", "pos": [ 4, 9 ] }
{ "id": "C0035696", "name": "messenger rna", "pos": [ 47, 60 ] }
diazepam was metabolized by human foetal liver microsomes to n-desmethyldiazepam and n-methyloxazepam as early as the 13th week of gestation .
NA
{ "id": "C0012010", "name": "diazepam", "pos": [ 0, 8 ] }
{ "id": "C0011279", "name": "desmethyldiazepam", "pos": [ 63, 80 ] }
catecholamines , in the order isoproterenol greater than epinephrine greater than norepinephrine , increase the rate of camp formation .
NA
{ "id": "C0007412", "name": "catecholamines", "pos": [ 0, 14 ] }
{ "id": "C0022245", "name": "isoproterenol", "pos": [ 30, 43 ] }
catecholamines , in the order isoproterenol greater than epinephrine greater than norepinephrine , increase the rate of camp formation .
NA
{ "id": "C0014563", "name": "epinephrine", "pos": [ 57, 68 ] }
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 82, 96 ] }
epinephrine , norepinephrine and serotonin were found to reduce the histamine uptake and the formation of methylhistamine , in a dose-dependent fashion .
NA
{ "id": "C0014563", "name": "epinephrine", "pos": [ 0, 11 ] }
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 14, 28 ] }
intracerebroventricular administration of methionine-enkephalin or morphine sulfate immediately prior to naloxone administration inhibited the precipitated withdrawal jumping response in mice rendered dependent on morphine by the pellet implantation method .
NA
{ "id": "C0066814", "name": "morphine", "pos": [ 67, 75 ] }
{ "id": "C0026549", "name": "morphine", "pos": [ 214, 222 ] }
the effect of secretotogues and 2-methylpentan-2,4-diol on the microtubule-tubulin equilibrium and the release of growth hormone from bovine anterior pituitary slices .
NA
{ "id": "C0037663", "name": "growth hormone", "pos": [ 114, 128 ] }
{ "id": "C0032016", "name": "anterior pituitary", "pos": [ 141, 159 ] }
in general , amino acid concentrations were higher in follicular fluid than in blood plasma : only the concentration of cys was significantly lower in follicular fluid than in plasma , while asp , thr , glu , glu-nh2 , gly , ala , and met showed concentrations that were not significantly different in either biologic fluid .
NA
{ "id": "C0002520", "name": "amino acid", "pos": [ 13, 23 ] }
{ "id": "C0017890", "name": "gly", "pos": [ 219, 222 ] }
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed .
NA
{ "id": "C0301713", "name": "aromatic amino acids", "pos": [ 166, 186 ] }
{ "id": "C0031453", "name": "phenylalanine", "pos": [ 189, 202 ] }
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed .
NA
{ "id": "C0301713", "name": "aromatic amino acids", "pos": [ 166, 186 ] }
{ "id": "C0041485", "name": "tyrosine", "pos": [ 205, 213 ] }
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed .
NA
{ "id": "C0301713", "name": "aromatic amino acids", "pos": [ 166, 186 ] }
{ "id": "C0041249", "name": "tryptophan", "pos": [ 220, 230 ] }
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed .
NA
{ "id": "C0002521", "name": "branched", "pos": [ 307, 315 ] }
{ "id": "C0042285", "name": "valine", "pos": [ 336, 342 ] }
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed .
NA
{ "id": "C0002521", "name": "branched", "pos": [ 307, 315 ] }
{ "id": "C0023401", "name": "leucine", "pos": [ 362, 369 ] }
patients with chronic liver disease with superimposed acute insults , i.e. , gastrointestinal bleeding , infection , alcoholic hepatitis , had elevated levels of the aromatic amino acids , phenylalanine , tyrosine , and tryptophan , as well as methionine , glutamate , and aspartate , whereas levels of the branched chain amino acids , valine , leucine , and isoleucine , were consistently depressed .
NA
{ "id": "C0002521", "name": "branched", "pos": [ 307, 315 ] }
{ "id": "C0022192", "name": "isoleucine", "pos": [ 359, 369 ] }
those patients with previously normal livers and acute hepatic necrosis , i.e. , `` '' fulminant hepatitis , '' '' had grossly elevated levels of all amino acids except the branched chain amino acids , which were normal .
NA
{ "id": "C0002520", "name": "l amino aci", "pos": [ 148, 159 ] }
{ "id": "C0002521", "name": "branched chain amino aci", "pos": [ 173, 197 ] }
combination pills and sequentials are widely used , the possible methods of a pure progestin contraception are : minipills , three-month-injections , implanted silastic capsules with progestional compounds , progestin impregnated intrauterine devices , vaginal silastic rings impregnated with progestional compounds .
NA
{ "id": "C0994475", "name": "pills", "pos": [ 12, 17 ] }
{ "id": "C0006935", "name": "capsules", "pos": [ 169, 177 ] }
the ribosomal fraction exhibited intense protective antigenicity in mice and chickens , but the lipopolysaccharide ( endotoxin ) and the other bacterial cell fraction obtained in this experiment did not .
NA
{ "id": "C0023810", "name": "lipopolysaccharide", "pos": [ 96, 114 ] }
{ "id": "C0014264", "name": "endotoxin", "pos": [ 117, 126 ] }
upon addition of hydrogen ion , urea , and sodium chloride to urines and broth , ph proved to be the major killing factor , but urea and nacl were also bactericidal .
NA
{ "id": "C0008203", "name": "chloride", "pos": [ 50, 58 ] }
{ "id": "C0037494", "name": "nacl", "pos": [ 137, 141 ] }
the binding of glycolipid to lymphocytes was only partially specific since unlabeled glycolipid r595 , lipid a , and lps did not completely inhibit the uptake of 14c-labeled glycolipid r595 .
NA
{ "id": "C0023767", "name": "lipid a", "pos": [ 103, 110 ] }
{ "id": "C0023810", "name": "lps", "pos": [ 117, 120 ] }
infection with p3 virus was accompanied by minimal bronchitis and bronchiolitis only , whereas p9-infected animals exhibited marked bronchitis , bronchiolitis , and pneumonia .
NA
{ "id": "C0006277", "name": "bronchitis", "pos": [ 51, 61 ] }
{ "id": "C0006271", "name": "bronchiolitis", "pos": [ 145, 158 ] }
the complex membrane antigen was exposed on the outside of the mycoplasmic cell because absorption of antiserum with live organisms removed antibody to this component .
NA
{ "id": "C0020960", "name": "antiserum", "pos": [ 102, 111 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 140, 148 ] }
the antiendotoxic activity of lipid a antiserum was studied in rabbits , using lipid a ( lipopolysaccharide ) -induced fever and skin necrosis as test systems .
NA
{ "id": "C0023767", "name": "lipid a", "pos": [ 30, 37 ] }
{ "id": "C0023810", "name": "lipopolysaccharide", "pos": [ 89, 107 ] }
however , in animals that were pretreated ( day 0 ) with a single dose of lipid a ( lipopolysaccharide ) , a significant protective effect of passively transferred antiserum ( day 1 ) to lipid a ( lipopolysaccharide fever ) ( day 2 ) was observed .
NA
{ "id": "C0023767", "name": "lipid a", "pos": [ 74, 81 ] }
{ "id": "C0023810", "name": "lipopolysaccharide", "pos": [ 197, 215 ] }
also , the lipid a ( lipopolysaccharide ) -induced local shwartzman reaction could be prevented by lipid a antiserum .
NA
{ "id": "C0023810", "name": "lipopolysaccharide", "pos": [ 21, 39 ] }
{ "id": "C0023767", "name": "lipid a", "pos": [ 99, 106 ] }
the fever protection mediated by lipid a antiserum seemed to be lipid a ( lipopolysaccharide ) specific with regard to both the preparative and the challenge injections .
NA
{ "id": "C0023767", "name": "lipid a", "pos": [ 33, 40 ] }
{ "id": "C0023810", "name": "lipopolysaccharide", "pos": [ 74, 92 ] }
both groups of hamster sera also gave virtually identical patterns , suggesting that the two enzyme forms used as antigen share common antigenic determinants .
NA
{ "id": "C0003320", "name": "antigen", "pos": [ 114, 121 ] }
{ "id": "C0003316", "name": "antigenic determinants", "pos": [ 135, 157 ] }
the presence of the material was not related to the source of malignancy , presence of carcinoembryonic or hepatitis antigens or of such autoantibodies as rheumatoid factor or anti-dna .
NA
{ "id": "C0004358", "name": "autoantibodies", "pos": [ 137, 151 ] }
{ "id": "C0035448", "name": "rheumatoid factor", "pos": [ 155, 172 ] }
the validity of the inert gas clearance method for measuring choroidal blood flow has recently been demonstrated by studying the diffusion of krypton in ocular tissue .
NA
{ "id": "C0017112", "name": "inert gas", "pos": [ 20, 29 ] }
{ "id": "C0022792", "name": "krypton", "pos": [ 142, 149 ] }
the unmounted sections are examined and photographed in the fluorescence microscope , and then stained for acetylcholinesterse according to holmstedt 's modification of the koelle thiocholine method ( incubation for 4-6 h with acetylthiocholine as substrate and mipafox as inhibitor of non-specific cholinesterases ) .
NA
{ "id": "C0039883", "name": "thiocholine", "pos": [ 180, 191 ] }
{ "id": "C0001066", "name": "acetylthiocholine", "pos": [ 227, 244 ] }
a quantitative method has been developed for the determination of alpha- and beta-carotenes and beta-cryptoxanthin , the provitamin a carotenoids in orange juice .
NA
{ "id": "C0053396", "name": "beta-carotenes", "pos": [ 77, 91 ] }
{ "id": "C0007271", "name": "carotenoids", "pos": [ 134, 145 ] }
the relative absorbance values obey beer 's law in the range of 1-10 mug dht/ml ethanol .
NA
{ "id": "C0004922", "name": "beer 's", "pos": [ 36, 43 ] }
{ "id": "C0001962", "name": "ethanol", "pos": [ 80, 87 ] }
the human histone messenger rna ( mrna ) species associated with various polyadenylated [ poly ( a ( + ) ) ] and nonpolyadenylated [ poly ( a ( - ) ) ] components of 4 to 18 s rna were determined by translation of these rna fractions in vitro using a krebs ii ascites cell-free system followed by resolution of histones synthesized in vitro on polyacrylamide gels containing triton x-100 .
NA
{ "id": "C0035696", "name": "messenger rna", "pos": [ 18, 31 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 220, 223 ] }
the results of these studies indicate that poly ( a ( - ) ) 4 to 18 s rna from s phase hela polyribosomes contains : ( a ) large quantities of discrete 7.4 and 8 s rna species which are not functional histone mrna ;
NA
{ "id": "C0035668", "name": "rna", "pos": [ 70, 73 ] }
{ "id": "C0887909", "name": "functional", "pos": [ 190, 200 ] }
( c ) 9.2 to 10.7 s rna which contains mixtures of incompletely resolved histone h2b , h2a , and h3 mrna ( these mrna species do not closely correspond to discrete rna subfractions resolvable by our techniques . ) ;
NA
{ "id": "C0035696", "name": "mrna", "pos": [ 100, 104 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 164, 167 ] }
the lysine-fermenting clostridium sb4 is shown to contain a new type of beta-keto acid-degrading enzyme that converts 3-keto-5-aminohexanoate and acetyl-coa reversibly to l-3-aminobutyryl-coa and acetoacetate .
NA
{ "id": "C0022618", "name": "keto acid", "pos": [ 77, 86 ] }
{ "id": "C0000988", "name": "acetoacetate", "pos": [ 196, 208 ] }
the product formed from beta-alanyl-coa and acetoacetate is a neutral beta-keto acid , presumably 3-keto-5-aminopentanoic acid ;
NA
{ "id": "C0000988", "name": "acetoacetate", "pos": [ 44, 56 ] }
{ "id": "C0022618", "name": "keto", "pos": [ 100, 104 ] }
the dissociation constants determined for cortisol , cortisone , cortexolone , progesterone , and 20beta-hydroxyprogesterone were at least 1 order of magnitude greater than the corresponding kinetic constants , and these findings suggest the presence of a kinetically insignificant binding site .
NA
{ "id": "C0033308", "name": "progesterone", "pos": [ 79, 91 ] }
{ "id": "C0020387", "name": "hydroxyprogesterone", "pos": [ 105, 124 ] }
effects of various salts show the following effectiveness of anions in dissociating the proteins , so4 ( 2- ) less than cl- less than br- less than clo4- less than scn- less than or equal to i- less than ccl3coo- , the first two members being association-inducing ions .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 61, 67 ] }
{ "id": "C0021966", "name": "i", "pos": [ 264, 265 ] }
effects of various salts show the following effectiveness of anions in dissociating the proteins , so4 ( 2- ) less than cl- less than br- less than clo4- less than scn- less than or equal to i- less than ccl3coo- , the first two members being association-inducing ions .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 61, 67 ] }
{ "id": "C0022023", "name": "ions", "pos": [ 264, 268 ] }
the discrepancy between the effectiveness of the anions in dissociating the protein and the hofmeister pattern of these ions has been discussed .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 49, 55 ] }
{ "id": "C0022023", "name": "ions", "pos": [ 120, 124 ] }
formation of ethanolamine phosphoglycerides , as a result of serine phosphoglycerides decarboxylation , has been analyzed by using a simplified compartmental model .
NA
{ "id": "C0162448", "name": "phosphoglycerides", "pos": [ 26, 43 ] }
{ "id": "C0031623", "name": "serine phosphoglycerides", "pos": [ 61, 85 ] }
of the 0.67 nmol/mg of protein turned over per h in the diacylserine phosphoglyceride compartment , 0.14 nmol/mg of protein are converted into the ethanolamine phosphoglycerides .
NA
{ "id": "C0162448", "name": "phosphoglyceride", "pos": [ 69, 85 ] }
{ "id": "C0031618", "name": "ethanolamine phosphoglycerides", "pos": [ 147, 177 ] }
while a minor amount of elastase 2 is eluted in a position consistent with alpha1-antitrypsin-elastase 2 complex , no free elastase or free proelastase is detectable .
NA
{ "id": "C0064833", "name": "elastase 2", "pos": [ 24, 34 ] }
{ "id": "C0030306", "name": "elastase", "pos": [ 143, 151 ] }
addition of exogenous elastase 2 to normal serum prior to gel filtration on g-200 produced an increase only in the peak of radioimmunoassayable elastase bound to alpha1-antitrypsin .
NA
{ "id": "C0064833", "name": "elastase 2", "pos": [ 22, 32 ] }
{ "id": "C0030306", "name": "elastase", "pos": [ 144, 152 ] }
human pancreatic elastase 1 , anionic trypsin , chymotrypsin i , and chymotrypsin ii do not cross-react in this assay system .
NA
{ "id": "C0003075", "name": "anionic", "pos": [ 30, 37 ] }
{ "id": "C0021966", "name": "i", "pos": [ 109, 110 ] }
the total enthalpy for assembly of a mole of unliganded hemoglobin tetramers from unliganded chains is -61.6 +/- 3.5 kcal , or approximately twice the value for oxygenated hemoglobin .
NA
{ "id": "C0019016", "name": "a", "pos": [ 7, 8 ] }
{ "id": "C0019046", "name": "hemoglobin", "pos": [ 172, 182 ] }
two-dimensional electrophoresis of 32p-labeled basic ribosomal proteins showed two labeled proteins , p1 and p2 , both of which were localized to the 40 s ribosomal subunit .
NA
{ "id": "C0035552", "name": "ribosomal proteins", "pos": [ 53, 71 ] }
{ "id": "C0033684", "name": "proteins", "pos": [ 91, 99 ] }
analysis of hexosamines showed that the sample contained 96 per cent glucosamine , confirming the identification of hyaluronic acid .
NA
{ "id": "C0019478", "name": "hexosamines", "pos": [ 12, 23 ] }
{ "id": "C0017718", "name": "glucosamine", "pos": [ 69, 80 ] }
alcohol then binds to the unprotonated form of the functional group with a pka of 7.6 in the binary enzyme-nad+ complex and converts the enzyme to the alkaline conformation .
NA
{ "id": "C0026741", "name": "enzyme", "pos": [ 100, 106 ] }
{ "id": "C0014442", "name": "enzyme", "pos": [ 137, 143 ] }
this potentiation of the effect of insulin on glucogen synthase i activity depended on the time of incubation with glucose and on the concentration of the hexose .
NA
{ "id": "C0017725", "name": "glucose", "pos": [ 115, 122 ] }
{ "id": "C0019494", "name": "hexose", "pos": [ 155, 161 ] }
conditions which permitted the annealing of globin mrna to cdna-cellulose were selected and the sequence specificity for hybridization to cdna-cellulose was determined using 28 s ribosomal rna , polyadenylic acid , and mouse l-cell rna .
NA
{ "id": "C0035701", "name": "ribosomal rna", "pos": [ 179, 192 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 232, 235 ] }
the amount of large single-stranded polynucleotide generated by the action of the recbc dnase increases as the atp concentration increases and , at 0.5 mm atp , becomes equivalent to the amount of acid-soluble nucleotide formed .
NA
{ "id": "C0032550", "name": "polynucleotide", "pos": [ 36, 50 ] }
{ "id": "C0028630", "name": "nucleotide", "pos": [ 210, 220 ] }
efflux of l-proline from the membrane vesicles , like uptake , showed stimulatory effects when the na+ gradient and l-proline were on the same side , and inhibitory effects when the na+ gradient and the imino acid were on opposite sides of the membrane .
NA
{ "id": "C0033382", "name": "l-proline", "pos": [ 10, 19 ] }
{ "id": "C0020931", "name": "imino acid", "pos": [ 203, 213 ] }
the na+ gradient-dependent rate of l-proline uptake was strongly inhibited by other imino acids , suggesting that l-imino acids have a common transport system .
NA
{ "id": "C0033382", "name": "proline", "pos": [ 37, 44 ] }
{ "id": "C0020931", "name": "imino acids", "pos": [ 116, 127 ] }
the observation that both casein and type ii histone are phosphorylated to the same extent at 1 mm and 10 mm mg2+ suggested that high mg2+ may be altering the conformation of phosphorylase kinase thus rendering more phosphorylation sites accessible to protein kinase .
NA
{ "id": "C0031713", "name": "phosphorylase kinase", "pos": [ 175, 195 ] }
{ "id": "C0033640", "name": "protein kinase", "pos": [ 252, 266 ] }
since the phosphorylation of phosphorylase kinase by either the protein kinase-catalyzed or autocatalytic reaction can result in the incorporation of 7 to 9 mol of phosphate , the finding that only about seven sites become phosphorylated by both mechanisms acting together suggest that activation by these two mechanisms may involve common phosphorylation sites .
NA
{ "id": "C0031713", "name": "phosphorylase kinase", "pos": [ 29, 49 ] }
{ "id": "C0033640", "name": "protein kinase", "pos": [ 64, 78 ] }
adenosine and 2-chloroadenosine stimulate adenylate cyclase in membranes from y-1 and i-10 cells at concentrations slightly greater than are effective for steroidogenesis .
NA
{ "id": "C0001443", "name": "adenosine", "pos": [ 0, 9 ] }
{ "id": "C0000275", "name": "2-chloroadenosine", "pos": [ 14, 31 ] }
peak c migrated like glycoprotein pas-2 and protein band 5 , the actin-like , water-soluble membrane protein .
NA
{ "id": "C0033684", "name": "protein", "pos": [ 26, 33 ] }
{ "id": "C0025252", "name": "membrane protein", "pos": [ 92, 108 ] }
electron acceptors which function with this enzyme are fad , fmn , riboflavin , ferredoxin , and methyl viologen , but not nad or nadp .
NA
{ "id": "C0016388", "name": "fmn", "pos": [ 61, 64 ] }
{ "id": "C0035527", "name": "riboflavin", "pos": [ 67, 77 ] }
dead end inhibition studies carried out in the presence of the products guanine and ribose 1-phosphate , respectively , showed that the kinetically significant abortive ternary complexes of enzyme-guanine-inorganic orthophosphate ( eqb ) and enzyme-guanose-ribose 1-phosphate ( eap ) are formed .
NA
{ "id": "C0026741", "name": "complexes", "pos": [ 177, 186 ] }
{ "id": "C0014442", "name": "enzyme", "pos": [ 242, 248 ] }
soluble cell extracts from simian virus 40 transformed mouse 3t3 fibroblast cells ( sv101 ) and nontransformed mouse balb/c-3t3 cells were compared as microtubule assembly systems .
NA
{ "id": "C0007634", "name": "cell", "pos": [ 8, 12 ] }
{ "id": "C0016030", "name": "fibroblast", "pos": [ 65, 75 ] }
the results indicate that membrane proteins are displaced laterally into adjacent membrane regions before the fusion process and that fusion occurs between protein-depleted lipid bilayers .
NA
{ "id": "C0025252", "name": "membrane", "pos": [ 26, 34 ] }
{ "id": "C0033684", "name": "protein", "pos": [ 156, 163 ] }
the finding of protein-depleted blebs in regions of plasma and granule membrane interaction raises the interesting possibility that blebbing may be a process for exposing the granule contents to the extracellular space and for the elimination of excess lipid while conserving membrane proteins .
NA
{ "id": "C0033684", "name": "protein", "pos": [ 15, 22 ] }
{ "id": "C0025252", "name": "membrane proteins", "pos": [ 276, 293 ] }
a heterogeneous cell population is obtained , comprising approximately 60 % parenchymal cells , approximately 10 % myoepithelial cells , and approximately 30 % connective tissue cells , including fibroblasts , plasma cells , and microphages .
NA
{ "id": "C0007634", "name": "cell", "pos": [ 16, 20 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 196, 207 ] }
the plant lectin , concanavalin a ( con-a ) , and the ionophore , a-23187 ( specific for divalent cations ) , stimulated glucose transport in rat thymocytes .
NA
{ "id": "C0304052", "name": "plant lectin", "pos": [ 4, 16 ] }
{ "id": "C0009630", "name": "concanavalin a", "pos": [ 19, 33 ] }
the effect on chick embryo fibroblasts was visible by four hours and by six hours almost all cells had swelled and were becoming detached .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 27, 38 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 93, 98 ] }
levels determined in ottawa drinking water were 17 ppt alpha-bhc , 1.3 ppt lindane , 0.7 ppt aldrin , and less than 0.05 ppt for each of heptachlor , heptachlor epoxide , dieldrin , endrin , chlordane , o , p'-ddt , p , p'-ddd , p , p'-ddt , and p , p'-dde .
NA
{ "id": "C0019219", "name": "heptachlor", "pos": [ 137, 147 ] }
{ "id": "C0019220", "name": "heptachlor epoxide", "pos": [ 150, 168 ] }
the 24 h integrated concentrations of progesterone , 17-hydroxyprogesterone ( 17-ohp ) and cortisol were determined in 5 male subjects ranging in age from 25 to 36 years .
NA
{ "id": "C0033308", "name": "progesterone", "pos": [ 38, 50 ] }
{ "id": "C0020387", "name": "17-hydroxyprogesterone", "pos": [ 53, 75 ] }
in addition , there was a decrease in the specific activity of estriol compared with estrone and estradiol as well as measurable levels of estetrol in both patients .
NA
{ "id": "C0014927", "name": "estriol", "pos": [ 63, 70 ] }
{ "id": "C0014899", "name": "estetrol", "pos": [ 139, 147 ] }