Both the decrease of αKG and accumulation of D: -2-HG inhibit the activity of multiple dioxygenases including prolyl hydroxylase domain-2 (PHD2), collagen prolyl-4-hydroxylase, histone demethylases, and the ten-eleven translocation (TET) family of 5-methylcytosine hydroxylases.
C0040715
Chromosomal translocation