For example, in an acetaminophen (APAP)-induced hepatocellular injury model, plasma let-7b-5p was up-regulated as early as 3&#8201;h after dosing, whereas a significant change in ALT level was observed at 12&#8201;h. We then focused on the DILI type-specific miRNAs in plasma that were up-regulated at the early stage of injury.
C0860207
Drug-Induced Liver Disease