In addition, two amino acid substitutions in the extracellular domain of HLA-DQ&#945;1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60&#215;10(-10)) and of HLA-DQ&#946;1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20&#215;10(-9)) independently confer achalasia risk.
C0014848
Esophageal Achalasia