Significant genes in myeloma plasma cells from patients that were associated with early-onset bortezomib-induced peripheral neuropathy were the enzyme coding genes RHOBTB2 (upregulated by 1&#183;59 times; p=4&#183;5&#215;10(-5)), involved in drug-induced apoptosis, CPT1C (1&#183;44 times; p=2&#183;9&#215;10(-7)), involved in mitochondrial dysfunction, and SOX8 (1&#183;68 times; p=4&#183;28&#215;10(-13)), involved in development of peripheral nervous system.
C4721453
Peripheral Nervous System Diseases