Iyini i-genomics yezifo?
Ngokuvela kokulandelana kwezizukulwane ezilandelayo sithola idatha eyanele yokulandelana ukuze senze ibalazwe lamagciwane ezifo eziyinkimbinkimbi kuhlanganise ukungazali, umdlavuza webele noma isifo sika-Alzheimer. Ukuhlolwa kokuhlobana kwezakhi zofuzo kuyindlela ewusizo yokuthola izinguquko ezibangela izifo eziyinkimbinkimbi ezinjalo. Ngalezi zifundo, kuye kwatholakala izinkulungwane zezinhlobo ze - DNA ezihlobene nezifo nezimpawu ezifanayo. Ngaphezu kwalokho, kungenzeka ukuthi izakhi zofuzo zisetshenziswe ekubikezeleni, ekuxilongweni noma ekwelashweni kungenye yezindlela zokusebenzisa ezibaluleke kakhulu. Ucwaningo oluningi luxoxa ngezindlela ezithembisayo zokukhetha izakhi zofuzo ezizosetshenziswa nangezinkinga nezingibe zokusebenzisa izakhi zofuzo ukuze kubikezelwe ukuba khona kwezifo noma ukuxilongwa kwazo.  Ucwaningo lwe-genome-wide association luye lwakhomba ngempumelelo izinkulungwane zezinhlobonhlobo zofuzo ezivamile zezifo eziyinkimbinkimbi nezici; kodwa-ke, lezi zinhlobonhlobo ezivamile zichaza ingxenye encane kuphela yefa. Izinhlobo ezingavamile zingase zichaze okunye kokuntuleka kokudluliselwa kwefa. Izifundo zokulandelelana kwezakhi zofuzo ezinkulu ziye zalandelela ngokushesha izigidi zezakhi zofuzo eziphelele, futhi izifundo ezinjalo ziye zathola amakhulu ezigidi zezinhlobo ezingavamile. Izinkomba ezisebenzayo zibikezela umphumela noma umsebenzi wezinhlobo zofuzo futhi zisiza ukubeka phambili izinhlobo ezingavamile ezisebenzayo, futhi ukufaka lezi zinkomba kungakhuphula ngempumelelo amandla enhlangano yofuzo yezinhlobo ezingavamile ukuhlaziywa kwezifundo zokulandelana kwe-genome yonke. Amathuluzi athile asethuthukisiwe ukuhlinzeka ngokuhlaziywa kokuhlanganiswa kokuhlukahluka okuyi-all-in-one kwedatha yokulandelana kwe-genome yonke, kufaka phakathi ukuhlanganiswa kwedatha ye-genotype kanye nemibhalo yabo esebenzayo, ukuhlaziywa kokuhlanganiswa, isifinyezo somphumela nokubukwa. I-meta-analysis yezifundo zokulandelela i-genome ephelele inikeza isisombululo esikhangayo enkingeni yokuqoqa amasampula amakhulu ukuze kutholakale izinhlobo ezingavamile ezihambisana nama-phenotypes ayinkimbinkimbi.