Iyini injongo yokuphila, indawo yonke nakho konke okukhona?
Lesi sihloko besilokhu sixoxwa kakhulu izazi zemfundiso yenkolo, izazi zefilosofi, nososayensi kuwo wonke umlando wesintu. Nakuba ukuhlola okuningi okuphathelene nendawo yonke kushiya umbuzo ungaphenduliwe, izici eziyinhloko yilezi ezilandelayo.  Izazi zemfundiso yenkolo ezinkolweni eziningi zithi kunamandla ahlelekile aziwa ngokuthi uNkulunkulu anikeza isiqondiso endaweni yonke. Abantu abavumelana kangcono naleli qembu elihlelekile noma noNkulunkulu baqinisekiswa inhlanhla kulokhu kuphila noma kokulandelayo. Kukhona ukwehluka kwezinga labantu lokuzibandakanya kule nqubo nobuKristu obudinga umsindisi (uJesu) ukuze abantu bangene empilweni yangemva kokufa uma kuqhathaniswa nokufinyelela isimo esiphakeme sokuqaphela kulokhu kuphila noma ngokuzalwa kabusha.  Izazi zefilosofi ziyahlukahluka ngokuphathelene nencazelo yokuphila ezinemibono evelele elandela indlela yokufuna ukugcwaliseka komuntu siqu noma ukugcwaliseka kwabanye. Ukufuna ukugcwaliseka kwakho siqu kuye kwaba yingxenye eyinhloko yobukapitali, ukuzivikela, nokuthatha ingozi okuholela ekutholeni okusha kweSayensi neTheknoloji. Ukufuna ukwaneliseka kwabanye kuye kwaholela entuthukweni enkulu emsebenzini wokusiza abanye, ekulinganeni, nasenhlalakahleni yomphakathi. Lesi "sivumelwano sezenhlalo" siqinisekisa ukuzinza futhi sinikeza ithemba lokuthi imisebenzi elimazayo enjengokubulala, ukuphanga, njll iyadikibala futhi iyajeziswa.  Ososayensi babheka lombuzo ngombono wendawo yonke ebonakalayo. Njengoba kuye kwenziwa imizamo enjalo yokwakha "imfundiso yokuhlanganisa yonke into" ukuze kuboniswe isimiso esithile esiqondakalayo endaweni yonke. Abanye baye bagxila ekutadisheni kwabo ukuthi akunakwenzeka kanjani ukuba abantu badalwe endaweni yonke enamathuba avele abe ngengozi angenamkhawulo. Abanye ososayensi baye bavuma ukuthi lo mbuzo uyinto isayensi engafaneleki ukuyiphendula.  Okubaluleke kakhulu ukuthi uDouglas Adams, umbhali ovelele waseBrithani onguchwepheshe wokungaqondakali, waphendula umbuzo osencwadini ethi "The Hitchhikers Guide to the Galaxy" ngokuthi "42."