IGFBP3 yaqala nini ukuchazwa?
Context:I- Insulin-like growth factor-binding protein 3, eyaziwa nangokuthi i- IGFBP-3, iyiprotheni kubantu efakwe nge- IGFBP3 gene. IGFBP-3 ingenye yamaprotheni ayisithupha abopha i-IGF (IGFBP-1 kuya ku-IGFBP-6) anezakhiwo ezigcinwe kahle futhi abopha ama-insulin-like growth factors IGF-1 no-IGF-2 ngokuhlobana okukhulu. IGFBP-7, ngezinye izikhathi efakwe kulo mkhaya, ayihlanganyeli izici zesakhiwo ezigcinwe noma i-IGF ephezulu. Esikhundleni salokho, i-IGFBP- 7 ibopha i-IGF1R, evimbela ukubopha kwe-IGF- 1 ne-IGF- 2, okubangela i-apoptosis.  Umsebenzi IGFBP-3 yaqala ukuhlukaniswa, yachazwa, futhi yalinganiswa ngobuningi egazini lomuntu, ngo-1986. Inemisebenzi echazwe kahle emjikelezweni wegazi, endaweni engaphandle kwamangqamuzana, nangaphakathi kwamangqamuzana. Yiphrotheni eyinhloko yokuthutha i-IGF egazini, lapho ithwala khona izakhi zokukhula ngokuyinhloko eziyinkimbinkimbi eziqukethe iprotheni ebophayo, kungaba i-IGF-1 noma i-IGF-2, kanye neprotheni yesithathu ebizwa ngokuthi i-acid-labile subunit noma i-ALS.
I- Insulin-like growth factor-binding protein 3 noma i- IGFBP-3 yaqala ukuhlukaniswa, yachazwa, futhi yalinganiswa ngobuningi kuyi- plasma yomuntu, ngo - 1986.