Iodine-125 ine hafu youpenyu hwakareba sei?
Context:Iodine-125 (125I) inonzi radioisotope yeiodine iyo inoshandiswa muzviongorori zvehupenyu, kuongorora kwechirwere chenyukireya uye mukurapa kwemagetsi se brachytherapy kurapa zvirwere zvakasiyana-siyana, kusanganisira kenza yeprostate, uveal melanomas, uye tumors dzeuropi. Ndiyo radioisotope yechipiri inorarama kwenguva refu yeiodine, pashure peiodine-129. Hafu yenguva yayo mazuva 59,49 uye inoparara kupfurikidza nokutapwa kwemaerekitironi kusvika kumugariro unofadza we tellurium-125. Iyi mamiriro haasi metastable 125mTe, asi pane yakaderera simba mamiriro kuti anoora pakarepo kubudikidza gamma kuora ane kunonyanyisa simba 35 keV. Mamwe masimba akawandisa e125Te anokwanisa kushandurwa kuva maerekitironi anobuda mukati (pa35 keV), kana kuita maX-ray (kubva kuelectron bremsstrahlung), uyewo maerekitironi 21 eAuger, ayo anogadzirwa pamasimba akaderera e50 kusvika ku500 electron volts. Pakupedzisira, kugadzikana kwepasi 125Te kunogadzirwa sechigadzirwa chokupedzisira chokuparara. Muzvokurapa, kushandurwa kwemukati uye maAuger electron anokonzera kukuvadza kuduku kunze kwesero iro rine atomu yeisotope. X-rays uye gamma rays vane simba rakaderera zvakakwana kuti vape mwero wakakwirira wemwaranzi kusarudzwa kune micheka iri pedyo, mu "chigarire" brachytherapy apo makapu e isotope anosiiwa ari panzvimbo (125I inokwikwidza ne palladium-103 mukushandiswa kwakadaro) Nemhaka yehafu yenguva yakareba uye kubuda kwemapotoni ane simba shoma ayo anogona kuonekwa nemagamma-counter crystal detectors, 125I isotope inodiwa pakunyorera maantibodies mune radioimmunoassay uye mamwe maitiro ekuverenga gamma anosanganisira mapuroteni ari kunze kwemuviri. Zvinhu zvakafanana zve isotope zvinoita kuti ive inobatsira brachytherapy, uye kune dzimwe nzira dzekuongorora mishonga yenyukireya, umo inosungirirwa kumapuroteni (albumin kana fibrinogen), uye uko hafu yehupenyu hwakareba kupfuura iyo inopiwa ne123I inodiwa pakuongorora kana kuongorora kwemazuva anoverengeka. Iodine-125 inogona kushandiswa pakuongorora/kuona chithyroid, asi iodine-123 ndiyo inosarudzwa nokuda kwechinangwa ichi, nemhaka yokupinda kwakanaka kwemwaranzi uye kupfupika kwehafu yeupenyu (maawa 13). 125I inobatsira pakuongorora glomerular filtration rate (GFR) pakuongorora kana kuongorora varwere vane chirwere cheitsvo. Iodine-125 inoshandiswa pakurapa mubrachytherapy kurapwa kwemamota. Nokuda kwokurapa nemwaranzi kunobvisa zvinyama zvinopinza iodine (zvakadai se thyroid), kana kuti zvinopinza mishonga yemwaranzi ine iodine, beta-emitter iodine-131 ndiyo isotope inodiwa.
Hafu yenguva yeiodine-125 mazuva 59, 49.