I-Iodine-125 isetshenziselwa ukwelashwa okunjani?
Context:I-Iodine-125 (125I) iyi-radioisotope ye-iodine esetshenziswa ekuhlolweni kwezinto eziphilayo, ekwakhiweni kwezithombe zemithi yenuzi kanye nokwelashwa ngemisebe njenge-brachytherapy yokwelapha izimo eziningi, kufaka phakathi umdlavuza wendlala yesinye, ama-uveal melanomas, kanye namathumba obuchopho. Liyi-radioisotope yesibili ehlala isikhathi eside kunazo zonke ye-iodine, ngemva kwe-iodine-129. Isikhathi sayo sokuphila siyizinsuku ezingu - 59,49 futhi iyabola ngokubanjwa kwama - electron ibe i - tellurium - 125 evuthayo. Lesi simo asisiyo i-125mTe engaguquki, kodwa kunalokho isimo samandla aphansi esibola ngokushesha ngokubola kwe-gamma ngamandla aphezulu angama-35 keV. Amanye amandla angaphezu kwe-125 Te ashukumisayo angaguqulwa ngaphakathi abe ngama-electron akhishwe ngaphandle (futhi ku-35 keV), noma abe ngama-x-ray (kusuka ku-electron bremsstrahlung), kanye nama-electron angama-21 e-Auger, akhiqizwa ngamandla aphansi we-50 kuya ku-500 electron volts. Ekugcineni, kutholakala i-125Te esimweni esizinzile njengomkhiqizo wokugcina wokubola. Ezokwelapha, ukuguqulwa kwangaphakathi nama-Auger electron kubangela umonakalo omncane ngaphandle kweseli eliqukethe i-athomu ye-isotope. Imisebe ye-X nemisebe ye-gamma inamandla aphansi ngokwanele ukuletha umthamo omkhulu wemisebe ngokuzikhethela ezicutshini eziseduze, ku-brachytherapy "engunaphakade" lapho ama-isotope capsules eshiywe endaweni (125I incintisana ne-palladium-103 ekusetshenzisweni okunjalo) Ngenxa yesikhathi sayo sokuphelisa isikhathi eside nokukhishwa kwama-photon anamandla aphansi angatholakala ngama-gamma-counter crystal detectors, i-125I i-isotope ekhethwayo yokumaka ama-antibodies ku-radioimmunoassay nakwezinye izinqubo zokubalwa kwe-gamma ezibandakanya amaprotheni ngaphandle komzimba. Izici ezifanayo ze-isotope zenza ukuthi isetshenziselwe i-brachytherapy, kanye nezinqubo ezithile zokuhlola imithi ye-nuclear, lapho inamathela khona kumaprotheni (i-albumin noma i-fibrinogen), futhi lapho kudingeka khona isigamu sempilo ende kunaleyo enikezwe yi-123I yokuxilonga noma izivivinyo zaselebhu ezithatha izinsuku eziningana. I-Iodine-125 ingasetshenziswa ekuhloleni/ ekutholeni izithombe ze-thyroid, kodwa i-iodine-123 iyathandwa ngale njongo, ngenxa yokungena kwemisebe kangcono nesikhathi esifushane sokusebenza (amahora angu-13). I-125I iyasiza ekuhlolweni kwe- glomerular filtration rate (GFR) ekuxilongweni noma ekuqapheni iziguli ezinesifo sezinso. I-Iodine-125 isetshenziswa ekwelapheni ekwelapheni izicubu nge-brachytherapy. Ukuze kususwe izicubu ezifaka i- iodine (njenge- thyroid), noma ezifaka i- radiopharmaceutical equkethe i- iodine, i- beta-emitter i- iodine-131 yi- isotope ekhethwayo.
I- Iodine-125 isetshenziswa ekuhlolweni kwezinto eziphilayo, ekwakhiweni kwezithombe zezokwelapha zenuzi nasekwelapheni ngemisebe njenge- brachytherapy yokwelapha izimo eziningi, kuhlanganise nomdlavuza wendlala yesinye, ama-uveal melanomas, namathumba obuchopho.