Njengoba kunikezwe lesi sigaba, khipha uhlu lwamagama angadlalwa ngumsebenzisi walo mdlalo.
Context:Phakathi nomkhankaso womdlali oyedwa, umdlali ulawula abalingiswa abahlanu abahlukene ngombono womuntu wokuqala. Umdlali ulawula ngokuyinhloko uSergeant Gary "Roach" Sanderson, oyilungu laseBrithani leqembu lamasosha akhethekile abizwa ngeTask Force 141. Ngaphezu kukaRoach, umdlali uzophinde alawule i-Private First Class uJoseph Allen (Troy Baker) kanye no-Private James Ramirez we-US Army 1st Battalion / 75th Ranger Regiment. UCaptain John "Soap" MacTavish (Kevin McKidd) manje usebenza njengelungu eliphakeme leTask Force 141, esebenza njengomphathi ophakeme kaRoach futhi uba ngumlingiswa odlalwayo emisebenzini emithathu yokugcina yomdlalo. Okokugcina, umdlali uthatha indima yomkhumbi-mkhathi ohlala e-International Space Station ngesikhathi sempi phakathi kwe-United States neRussia.  Abalingiswa abangadlalwa (ama-NPC) bavelele endabeni: Kwa-Task Force 141, uLieutenant Simon "Ghost" Riley (uCraig Fairbrass), ofihla ubuso bakhe nge-balaclava yokunyathelisa ikhanda, usebenza njengomsizi kaSoap. Kuma-United States Army Rangers, uSergeant Foley (Keith David), kanye nomuntu ophansi kwakhe, uCoporal Dunn (Barry Pepper), ekuqaleni ungumholi weqembu likaJoseph Allen, futhi uba ngumholi weqembu likaJames Ramirez kamuva endabeni. ULieutenant General Shepherd (uLance Henriksen) ungukhomanda we-United States Army Rangers kanye ne-Task Force 141. Ezinye izinhlamvu ezisekelayo ezibuya ku-Call of Duty 4 zifaka phakathi uCaptain John Price (uBilly Murray), owayengukhomanda kaMacTavish eBritish Special Air Service owavalelwa eRussia, kanye nomtsheli waseRussia owaphenduka umshayeli wezempi "uNikolai" (uSven Holmberg).
1. Izinkomo USergeant Gary "Roach" Sanderson 2. Izingelosi UJoseph Allen 3. Izindaba Ezinhle UJames Ramirez 4. Izidakamizwa UJohn "Soap" MacTavish 5. Izingelosi Umkhathi ongaziwa