I-wat id incazelo ye-DNA?
Ukuchazwa kwe-DNA noma ukuchazwa kwe-genome inqubo yokukhomba izindawo zamagciwane nazo zonke izindawo ezifaka amakhodi ku-genome nokubona ukuthi lawo magciwane enzani. Isichasiso (kungakhathaliseki ukuthi sisho ukuthini) siyinothi elengezwe ngenjongo yokuchaza noma ukuphawula. Lapho nje i-genome seyihleliwe, kudingeka ukuba ibhalwe phansi ukuze kuqondwe. Ama-gene e-genome e-eukaryotic angafakwa amaphuzu ngokusebenzisa amathuluzi ahlukahlukene okufaka amaphuzu afana ne-FINDER. Umgudu wesimanje wokuphawula ungasekela isikhombimsebenzisi sewebhu esisebenziseka kalula kanye nokufakwa kwesoftware okufana ne-MOSGA. Imibhobho yesimanje yezincazelo zezakhi zofuzo zama-prokaryotic yiBakta, Prokka ne-PGAP.  Ukuze kubhalwe i-DNA, ukulandelana kwezinto zofuzo okwakungaziwa ngaphambili kunothiswa ngolwazi oluhlobene nesikhundla se-genome nemingcele ye-intron-exon, ukulandelana okulawulayo, ukuphindaphinda, amagama e-gene nemikhiqizo yamaprotheni. Lokhu kuphawula kugcinwa ezisekelweni ze-genomic ezifana ne-Mouse Genome Informatics, i-FlyBase, ne-WormBase. Izinto zemfundo ezihlobene nezici ezithile zokuchazwa kwezinto eziphilayo ezivela ekamu lokuchazwa kwe-Gene Ontology lika-2006 nemicimbi efanayo iyatholakala kuwebhusayithi ye-Gene Ontology.  I-National Center for Biomedical Ontology ithuthukisa amathuluzi okuzenzekelayo okuzenzekelayo kwamarekhodi e-database ngokusekelwe ekuchazeni okubhaliwe kwalawo marekhodi.  Njengenqubo ejwayelekile, i-dcGO inenqubo ezenzakalelayo yokuqagela izibalo izinhlangano phakathi kwamagama e-ontology kanye nezizinda zamaprotheni noma inhlanganisela yezizinda ezivela emibhalweni ekhona yezinga le-gene / amaprotheni.