Tichifunga nezvorondedzero yemutambi weBig Bang Theory, sarudza bedzi vatambi vakuru.
Context:Johnny Galecki saLeonard Hofstadter: Muongorori wefizikisi ane IQ ye173, uyo akagamuchira Ph.D. paakanga ava nemakore makumi maviri nemana. Leonard in'anga inofarira mitambo yemavhidhiyo, mabhuku enyambo, uye Dungeons & Dragons. Leonard ndiye murume akarurama wetsamba yacho, achigoverana imba muPasadena, CA, naSheldon Cooper. Leonard anodanana nomuvakidzani wake mutsva Penny pavanotanga kuonana, uye vanopedzisira varoorana.  Jim Parsons saSheldon Cooper: Pakutanga kubva kuGalveston, Texas, Sheldon aive mwana anoshamisa ane eidetic memory uyo akatanga kukoreji aine makore gumi nerimwe uye akawana Ph.D. aine makore gumi nematanhatu. Iye inyanzvi yefizikisi inotsvakurudza quantum mechanics nedzidziso yetambo, uye, pasinei zvapo neIQ yake ye187, anowana mativi akawanda etsika emigariro yomunzanga akaoma kunzwisisa. Iye akatsunga kuva nenzira yake amene, nguva dzose anozvirumbidza pamusoro pouchenjeri hwake, uye ane nzira youpenyu yakanyanyodzorwa. Pasinei nezvakaipa izvi, anotanga kudanana naAmy Farrah Fowler, uye vanopedzisira varoorana.  Kaley Cuoco saPenny: Aida kuita mutambi kubva kuOmaha, Nebraska. Penny anotamira muimba iri mhiri kworusvingo rwaSheldon naLeonard. Anobatira patafura uye pane dzimwe nguva anotarisira bhawa paThe Cheesecake Factory. Pashure pokurasa tariro yokuva mutambi anobudirira, Penny anova mumiririri wokutengesa wemishonga. Penny anova shamwari yaBernadette naAmy, uye vanowanzogara mudzimba dzomumwe nomumwe. Penny naLeonard vanoumba ukama uye pakupedzisira vanoroorana.  Simon Helberg saHoward Wolowitz: Injiniya wezvemuchadenga uyo akawana dhigirii rake reMasters paMassachusetts Institute of Technology. Howard muJudha uye aigara naamai vake, Debbie (Carol Ann Susi). Kusiyana naSheldon, Leonard, Raj, Bernadette, naAmy, Howard haana dhigirii rokupedza kudzidza. Anodzidzira kuva muchadenga uye anoenda muchadenga somunhu ane unyanzvi hwokutakura zvinhu paInternational Space Station. Pakutanga Howard anozviona somurume anoda vakadzi, asi gare gare anotanga kufambidzana naBernadette, uye vanovimbisana kuroorana. Howard anewo muitiro wokupambadza mari pamatoyi uye anokakavadzana naBernadette nemhaka yemari yake yakaderera zvikuru somwenjiniya uye mari yake yakakwirira somugadziri wemishonga yemishonga.  Kunal Nayyar saRajesh Koothrappali: A particle astrophysicist anobva kuNew Delhi, India. Pakutanga, Raj akanga asingagoni kutaura, achitadza kutaura nevakadzi kana kuti kuva pedyo navo kunze kwokunge adhakwa. Raj anewo zvaanofarira zvevakadzi uye anowanzotora chinzvimbo chevakadzi hushamwari hwake naHoward pamwe neboka revarume vana. Raj gare gare anodanana naLucy (Kate Micucci), uyo anotamburawo nekushushikana kwevanhu, asi zvinopedzisira zvapera. Gare gare anotaura naPenny pasina doro, achikunda kunyarara kwake kunosarudza. Anotanga kufambidzana naEmily Sweeney, uye ukama hwavo hunozova hwega. Mumwaka wekupedzisira wenyaya dzakateedzana, Raj ane chibvumirano chekudzokazve, chekudzokazve nemumwe muIndia, muchengeti wehotera anonzi Anu (Rati Gupta). Anewo Yorkshire Terrier inonzi Cinnamon. Vatambi ava vakatanga kunyorwa sevatambi vakakokwa uye gare gare vakakwidziridzwa kuva vatambi vakuru:  Sara Gilbert saLeslie Winkle (anodzokorora mwaka 1, nyeredzi mwaka 2, muenzi mwaka 3, 9): Mufizikisi anoshanda murabhoritari imwechete naLeonard. Mukuoneka, iye chaizvoizvo muenzani wechikadzi waLeonard uye ane dzidziso dzesayenzi dzinopesana naSheldon. Leslie anoita zvepabonde zvisina kurongwa naLeonard uye gare gare Howard. Gilbert akasimudzirwa kuva nhengo huru yevatambi mumwaka wechipiri asi akatangazve chinzvimbo chemuenzi nekuti vagadziri vaisakwanisa kuuya nezvinhu zvakakwana zvehunhu. Gilbert akadzokera kuThe Big Bang Theory nokuda kwechikamu chayo chechi200.  Melissa Rauch saBernadette Rostenkowski-Wolowitz (anodzokororwa mwaka 3, nyeredzi mwaka 4<unk>12): Mukadzi wechidiki uyo pakutanga ari mushandi pamwe paThe Cheesecake Factory naPenny kuti abhadhare nzira yake kuburikidza nechikoro chakapedza kudzidza, kwaanodzidza microbiology. Bernadette anoziviswa kuna Howard naPenny; pakutanga, havasi kuwirirana, sezviri pachena vasina chinhu chakafanana. Vanofambidzana uye gare gare vanovimbisana kuroorana. Kunyange zvazvo kazhinji ari munhu ane mutsa uye ane unhu hwakanaka, Bernadette anokurumidza kutsamwa uye anogona kutsiva uye kupopota paanotsamwiswa.  Mayim Bialik saAmy Farrah Fowler (guest star season 3, starring seasons 4<unk>12): Mukadzi akasarudzwa neinternet yekufambidzana saiti semurume akakwana waSheldon, Amy anobva kuGlendale, CA. Nepo iye naSheldon pakutanga vachigoverana kusanzwisisana munzanga, mushure mekushamwaridzana naPenny naBernadette, anozopedzisira ave kufarira kudyidzana munzanga uye murudo. Ukama hwake naSheldon hunofambira mberi zvishoma nezvishoma kusvika pakuti Sheldon anomuona somusikana wake, uye pakupedzisira, vanoroorana. Amy anodavira kuti iye naPenny ishamwari dzapedyo, murangariro uyo Penny asingatangi kugoverana. Amy ane dhigirii rePh.D. muurobiology.  Kevin Sussman saStuart Bloom (anodzokorora mwaka 2<unk>5, 7, nyeredzi mwaka 6, 8<unk>12): Muridzi ane hunyoro, asina kuzvivimba muridzi wechitoro chemabhuku enyambo. Nyanzvi yokudhirowa mifananidzo, Stuart akapedza kudzidza paRhode Island School of Design ine mukurumbira. Kunyange zvazvo asingawirirani nevamwe, ane unyanzvi hwakanaka hwokukurukura nevanhu. Stuart anoreva kuti ane zvinetso zvemari uye kuti chitoro chemabhuku enyambo zvino chiriwo musha wake. Anokokwa gare gare kuti abatane neboka ravarume apo Howard ari muchadenga. Stuart anowana basa idzva rokutarisira amai vaHoward gare gare. Pashure porufu rwaMai Wolowitz, Stuart anopfuurira kugara mumusha mavo, pamwe chete naHoward naBernadette, kusvikira awana nzvimbo yake amene.  Laura Spencer saEmily Sweeney (anodzokorora mwaka 7<unk>8, 10, nyeredzi mwaka 9): Chiremba wezvirwere zveganda paHuntington Hospital. Emily akaenda kuHarvard uye anofarira zvinhu zvinotyisa, uye anotaura kuti anofarira basa rake nokuti anogona kucheka zvinhu nemapanga. Asati asangana naRaj, Emily akarongwa kuti aonane naHoward asingaoni. Pashure pokuwana purogiramu yaEmily yokufambidzana nayo paIndaneti, Raj anoita kuti Amy amubate somubatsiri wake panzvimbo pezvo. Hukama hwavo hunova hwakasarudzika, asi Raj anozoputsa naEmily paanosvika pakuda Claire (Alessandra Torresani), bartender uye munyori wevana.
Kaley Cuoco saPenny, Melissa Rauch saBernadette Rostenkowski-Wolowitz, Mayim Bialik saAmy Farrah Fowler