Tichifunga nezvezvikamu izvi pamusoro peAsperger Multiomics, chii chiri chinangwa chokubatanidza "omes" ose?
Context:Multiomics, multi-omics, integrative omics, "panomics" kana "pan-omics" inzira yekuongorora yezvinhu zvipenyu umo maseti e data ari akawanda "omes", akadai se genome, proteome, transcriptome, epigenome, metabolome, uye microbiome (kureva, meta-genome uye / kana meta-transcriptome, zvichienderana nekuti yakateedzana sei); mune mamwe mazwi, kushandiswa kwemazhinji omics matekinoroji ekudzidza hupenyu nenzira yakabatana. Nokubatanidza "omes" idzi, masayendisiti anogona kuongorora mashoko makuru ezvakaitika kare kuti awane ukama hutsva pakati pezvinhu zvipenyu, kutsvaka zviratidzo zvine chokuita noupenyu uye kuvaka zviratidzo zvakajeka zvechirwere uye zvepanyama. Mukuita kudaro, multiomics inobatanidza mashoko akasiyana-siyana eomics kuti iwane ukama kana kuti mubatanidzwa wegeno-pheno-envirotype unowirirana. Basa reOmicTools rinonyora zvinopfuura 99 software zvine chekuita nekuongororwa kwedata re multiomic, pamwe neanopfuura 99 dhatabhesi pamusoro penyaya iyi.  Nzira dzinoshandiswa pakuongorora zvinhu zvipenyu dzinowanzoshandiswa pakutsvakurudza zvinhu zvose. The American Society of Clinical Oncology (ASCO) inorondedzera panomics ichireva "kudyidzana kwemabasa ose omuviri mukati mesero uye nemamwe mabasa omuviri, kubatanidza mashoko akaunganidzwa nemiedzo yakanangwa... uye kuongorora kwenyika yose (akadai sokutevedzana kwegenome) nemamwe mashoko omurwere chaiwo".  Single-sero multiomics Bazi remunda we multiomics nderokuongorora kwedata remasero akawanda, rinonzi single-cell multiomics. Nzira iyi inotipa chisarudzo chisati chamboitwa chokutarira kuchinja kwematanho akawanda muutano nehosha pamwero wesero rimwe chete. Chinhu chakanakira kuongororwa kwakawanda ndechekuderedza zvinhu zvinovhiringidza zvinobva pakusiyana kwemasero, zvichibvumira kuwanikwa kwemasikirwo etsandanyama asina kufanana.  Nzira dzokuenzanisa genomic uye transcriptomic kuongorora kweimwe chete-sero dzinogona kuvakirwa pakukudziridza panguva imwe chete kana kuparadzaniswa kwepanyama kweRNA uye genomic DNA. Zvinobvumira nzwisiso isingagoni kuunganidzwa chete kubva kuongororo ye transcriptomic, sezvo RNA data isingabatanidzi nzvimbo dzisina-coding genomic uye ruzivo pamusoro pekusiyana kwehuwandu-huwandu hwekopi, somuenzaniso. Kuwedzerwa kweiyi nzira ndiko kubatanidzwa kweimwe-sero transcriptomes kune imwe-sero methylomes, kusanganisa imwe-sero bisulfite kutevedzana kune imwe-sero RNA-Seq. Dzimwe nzira dzokubvunza epigenome, se-single-cell ATAC-Seq uye single-cell Hi-C dziripowo.  Chinetso chakasiyana, asi chakabatana, kubatanidzwa kwemashoko eproteomic uye transcriptomic. Imwe nzira yokuita nayo kuyerwa kwakadaro ndeyokuparadzanisa lysates dzesero rimwe kuva mbiri, kugadzira hafu yeRNA, uye hafu yemapuroteni. Mapuroteni ari mu lysates anogona kuyerwa neproximity extension assays (PEA), somuenzaniso, iyo inoshandisa DNA-barcoded antibodies. Imwe nzira yakasiyana inoshandisa RNA inotsvaga simbi dzinorema nemapuroteni anorwisa mabhakitiriya kuti aongorore maseru akawanda.  Multiomics uye kudzidza kwemuchina Mukuenzanisa nekufambira mberi mune highthroughput biology, mashandisirwo ekudzidza kwemuchina kuongororwa kwedata rebiomedical ari kubudirira. Kubatanidzwa kweongororo yemashoko akawanda uye kudzidza kwemuchina kwakatungamirira kukuwanikwa kwema biomarkers matsva. Somuenzaniso, imwe yenzira dzomushandirapamwe we mixOmics inoshandisa nzira yakavakirwa pamusana peParcial Least Squares regression yekusarudzwa kwezvinhu (zvinyorwa zvinonzi biomarkers).   https://en.wikipedia.org/wiki/Multiomics
Nokubatanidza "omes" idzi, masayendisiti anogona kuongorora mashoko makuru ezvakaitika kare kuti awane ukama hutsva pakati pezvinhu zvipenyu, kutsvaka zviratidzo zvine chokuita noupenyu uye kuvaka zviratidzo zvakajeka zvechirwere uye zvepanyama. Mukuita kudaro, multiomics inobatanidza mashoko akasiyana-siyana eomics kuti iwane ukama kana kuti mubatanidzwa wegeno-pheno-envirotype unowirirana.