Marka la eego cutubyada ku saabsan Multiomics, waa maxay panomics?
Context:Multiomics, multi-omics, integrative omics, "panomics" ama "pan-omics" waa qaab falanqayn bayooloji ah oo xogta ay ku jiraan "omees" badan, sida genome, proteome, transcriptome, epigenome, metabolome, iyo microbiome (ie, meta-genome iyo / ama meta-transcriptome, iyadoo ku xiran sida loo kala saaro); si kale haddii loo dhigo, isticmaalka teknoolojiyada omics badan si loo barto nolosha si wadajir ah. Isku darista "ome"yadaas, saynisyahannadu waxay falanqeyn karaan xogta weyn ee bayoolojiga si ay u helaan xiriirro cusub oo u dhexeeya hay'adaha bayoolojiga, waxay tilmaami karaan biomarkers-yada la xiriira waxayna dhisi karaan calaamado adag oo cudur iyo jir ahaaneed. Marka sidaas la sameynayo, multiomics waxay isku dartaa xogta omics kala duwan si loo helo xiriir isku mid ah oo isku mid ah oo ku saabsan xiriirka ama ururka. Adeegga OmicTools wuxuu liis garaynayaa in ka badan 99 barnaamijyo software ah oo la xiriira falanqaynta xogta multiomic, iyo sidoo kale in ka badan 99 keydka macluumaadka ee mawduuca.  Nidaamyada bayolojiga nidaamyada waxay inta badan ku saleysan yihiin isticmaalka xogta falanqaynta guud. Ururka American Society of Clinical Oncology (ASCO) wuxuu qeexayaa panomics inuu tixraacayo "isdhexgalka dhammaan howlaha bayoolojiga ee unugyada iyo shaqooyinka kale ee jirka, isku darka xogta la soo ururiyey ee baaritaannada la beegsaday... iyo tijaabooyinka caalamiga ah (sida taxanaha hidda-wadaha) iyo macluumaadka kale ee bukaanka gaarka ah".  Waxyaabaha badan ee hal unug leh Laan ka mid ah multiomics waa falanqaynta xogta hal unug oo heerar badan leh, oo loo yaqaan'single-cell multiomics'. qaabkani wuxuu nagu siinayaa xal aan horay loo arag oo ku saabsan sida loo eego isbedelka heerarka kala duwan ee caafimaadka iyo jirada ee heerarka unugyada kaliya. Faa'iidada la xiriirta falanqaynta guud waa in la yareeyo waxyaabaha jahwareerka keena ee ka yimaada unugyada kala duwanaanshaha unugyada, taasoo u oggolaaneysa in la soo bandhigo qaab dhismeedka unugyada aan isku midka ahayn.  Qaababka falanqaynta hal unug ee genomic-ka iyo transcriptomic-ka ee isku xiga waxay ku saleysnaan karaan xoojinta isku mar ama kala soocida jirka ee RNA iyo DNA genomic. Waxay u oggolaanayaan aragtiyo aan laga soo ururin karin oo keliya falanqaynta transcriptomic, maadaama xogta RNA aysan ku jirin gobollada genomic-ka ee aan koodhka ku jirin iyo macluumaadka ku saabsan kala duwanaanshaha nambarka nuqulka, tusaale ahaan. Kordhinta habkan waa isku-darka transcriptomes-ka hal-unugyada hal-unugyada methylomes, isku-darka hal-unug bisulfite oo isku-dhafan si loo helo hal unug RNA-Seq. Farsamooyin kale oo lagu baarayo epigenome, sida ATAC-Seq iyo single-cell Hi-C ayaa sidoo kale jira.  Caqabad kale, laakiin la xidhiidha, waa isku-dhafka xogta proteomic iyo transcriptomic. Mid ka mid ah qaababka lagu sameeyo qiyaasta noocan oo kale ah ayaa ah in si jir ahaaneed loo kala saaro lysates-ka hal unug laba qaybood, iyadoo la adeegsanayo kala badh RNA, iyo kala badh borotiin. Waxyaabaha ku jira borotiinka ee lysates waxaa lagu qiyaasi karaa tijaabooyinka fidinta u dhow (PEA), tusaale ahaan, kuwaas oo adeegsada unugyada difaaca jirka ee loo yaqaan 'DNA-barcoded antibodies'. Qaab kale ayaa loo isticmaalaa isku darka baaritaannada RNA ee birta culus iyo unugyada difaaca ee borotiinka si loogu habeeyo cytometry mass for multiomic analysis.  Multiomics iyo barashada mashiinka Marka la barbar dhigo horumarka cilmiga noolaha ee wax soo saarka sare, codsiyada barashada mashiinka ee falanqaynta xogta bayoolajiga ayaa sii kordhaya. Isku darka falanqaynta xogta badan iyo barashada mashiinka waxay keentay in la ogaado calaamadaha cusub ee bayoolajiga. Tusaale ahaan, mid ka mid ah hababka mashruuca mixOmics wuxuu fuliyaa hab ku saleysan dib-u-dhac ku saleysan laba jibbaarada ugu yar ee qayb ahaan xulashada astaamaha (calaamadaha noolaha ee loo malaynayo).   https://en.wikipedia.org/wiki/Multiomics
Ururka American Society of Clinical Oncology (ASCO) wuxuu qeexayaa panomics inuu tixraacayo "isdhexgalka dhammaan howlaha bayoolojiga ee unugyada iyo shaqooyinka kale ee jirka, isku darka xogta la soo ururiyey ee baaritaannada la beegsaday... iyo tijaabooyinka caalamiga ah (sida taxanaha hidda-wadaha) iyo macluumaadka kale ee bukaanka gaarka ah".