Ndapota ndipei ndaza pfupi yezvinhu zvinokosha zvakawanikwa muGallo's lab.
Context:Pashure pokuteerera hurukuro yomudzidzi wezvinhu zvipenyu David Baltimore uye kukurudzirwazve nomushandi biyake anoongorora utachiona, Robert Ting, pamusoro pebasa romufi Howard Martin Temin, Gallo akatanga kufarira kudzidza nezvemaretrovirus, uye akaita kuti kudzidza kwawo kuve chinhu chikuru chaaiita murabhoritari yake. Muna 1976, Doris Morgan, mushandi wepagore rokutanga pashure pokunge apedza kudzidza pabasa raGallo, akakumbirwa naGallo kuti aongorore mvura yemakemikari yema lymphocyte akaitwa kuti akwanise kugadzira zvinhu zvinokura. Nokukurumidza akabudirira mukukura maT lymphocyte. Gallo, Morgan naFrank Ruscetti, mumwe mutsvakurudzi ari murabhoritari yaGallo, vakanyora pamwe chete nhau muScience vachirondedzera mutoo wavo. Boka raGallo rakaona izvi seT-cell growth factor (TCGF). Zita racho rakachinjwa muna 1978 kuva IL-2 (interleukin-2) neChipiri International Lymphokine Conference (iyo yakaitirwa muInterlaken, Switzerland). Kunyange zvazvo mishumo yapfuura yakanga yarondedzera mamorekuru anogadziriswa ane migumisiro yezvoupenyu, migumisiro uye biochemistry yezvinhu zvacho zvakanga zvisati zvanyatsorondedzerwa. Mumwe muenzaniso wakadaro wakanga uri mushumo waJulius Gordon muna 1965, uyo wakatsanangura kushanduka kweblastogenic kwema lymphocyte mune zvemukati zvemukati. Zvisinei, kukura kwemasero hakuna kuratidzwa uye rudzi rwemasero rwunobatwa haruna kuzivikanwa, zvichiita kuti kuzivikanwa kwezvinhu zvinobatanidzwa kuve kusinganzwisisiki uye basa rayo rechisikirwo risingazivikanwi. Kuwanikwa kweIL-2 kwakabvumira masero eT, aimbofungidzirwa kuva masero akafa, kuti akure zvikuru mumasikirwo kwenguva yokutanga, achivhura kutsvakurudza muzvinhu zvakawanda zveT cell immunology. Rabhoritari yaGallo gare gare yakachenesa uye yakaratidzira biochemically IL-2. Kufambira mberi uku kwakabvumirawo vatsvakurudzi kukudziridza masero eT uye kudzidza nezveutachiona hunoaita, hwakadai sehutachiona hweT-cell leukemia virus, kana kuti HTLV, utachiona hwokutanga hwokuziva vanhu, uhwo Bernard Poiesz, mumwe mushandi wepakoreji yaGallo akaita basa rinokosha pakuzviparadzanisa nahwo. Basa reHTLV mukurwara neropa rakajekeswa apo Kiyoshi Takatsuki navamwe vatsvakurudzi veJapan, vachishamiswa nokupararira kworudzi rusingawanzoitiki rweropa reropa, gare gare vakawana retrovirus imwe cheteyo, uye mapoka ose ari maviri akaratidzira kuti HTLV ndiyo yaiva honzeri. Panguva imwe cheteyo, leukemia yakafanana inobatanidzwa neHTLV yakawanwa neboka raGallo muCaribbean. Muna 1982, Gallo akagamuchira Lasker Award: "Nokuda kwezvidzidzo zvake zvokutanga izvo zvakatungamirira kukuwanwa kwoutachiona hwomunhu hwokutanga hweRNA [zita rekare reretroviruses] nokubatana kwahwo nedzimwe hosha dzeropa uye lymphomas".
Kukura zvinobudirira kwemasero eT lymphocyte munharaunda kwenguva yokutanga Interleukin-2 (IL-2) Human T-cell leukemia virus Retrovirus yomunhu yokutanga