IGFBP3 yakatanga kuzivikanwa rini?
Context:Insulin-like growth factor-binding protein 3, inozivikanwawo se IGFBP-3, ipuroteni iyo muvanhu inonyorwa ne IGFBP3 gene. IGFBP- 3 ndeimwe yemapuroteni matanhatu anosunga IGF (IGFBP- 1 kusvika IGFBP- 6) ayo ane zvivako zvakachengetedzwa zvikuru uye anosunga insulin- yakafanana nezvinhu zvinokura IGF- 1 uye IGF- 2 nehukama hwakakwirira. IGFBP-7, dzimwe nguva inosanganisirwa mumhuri iyi, haina zvikamu zvakachengetedzwa zvechimiro kana hukama hwepamusoro hwe IGF. Panzvimbo pezvo, IGFBP-7 inosunga IGF1R, iyo inovhara IGF-1 uye IGF-2 inosunga, zvichikonzera apoptosis.  Basa IGFBP- 3 yakatanga kusarudzwa, kunzi ndiyo inokonzera zvirwere, uye kuwanda kwayo mu plasma yomunhu, muna 1986. Iine mabasa akanyorwa zvakanaka mukuyerera kweropa, munzvimbo iri kunze kwemasero, uye mukati memasero. Iyo ndiyo puroteni huru inotakura IGF muropa, uko inotakura zvinhu zvinokura zvikurukuru muzvikamu zvakagadzikana zvine puroteni inosunga, ingava IGF-1 kana IGF-2, uye puroteni yechitatu inonzi acid- labile subunit kana ALS.
Insulin-like growth factor-binding protein 3 kana kuti IGFBP-3 yakatanga kusarudzwa, kutsanangurwa, uye kuverengwa mu plasma yomunhu, muna 1986.