Kule ndima, khipha izindlela zokwelapha i-ACO ohlwini olunezinhlamvu.
Context:Ukwelashwa kwe-ACO kusekelwe emibonweni yochwepheshe njengoba zingekho iziqondiso zomtholampilo ezamukelwa umhlaba wonke. Ukwelashwa ngokuvamile kusekelwe ekutheni izimpawu zomtholampilo ze-asthma noma i-COPD ziyizinto eziyinhloko yini. I-corticosteroids ephefumulwayo iyindlela yokwelapha eyinhloko kulabo abane-ACOS. Ama-corticosteroids adonswa ngomlomo (ICS) kufanele aqhubeke kulabo abane-asthma abahlakulela ukunciphisa ukuphendula komgudu womoya kuma-bronchodilators okuhambisana ne-ACO. Ukwelashwa kungandiswa ukuze kufake i-beta-agonist esebenza isikhathi eside (i-LABA) kanye nenhlanganisela ye-steroid ephefumulwayo (i-ICS-LABA) noma ngokungeza i-anti-muscarinic inhaler esebenza isikhathi eside (i-LAMA), eyaziwa ngokuthi ukwelashwa kathathu, kulabo abanesifo esibi kakhulu noma esiphikisayo.  Ama-antibody e-monoclonal aqondiswe ekuvuvukeni kohlobo 2 (okuyinto evelele e-asthma) asetshenziselwe ukwelapha i-asthma enzima, futhi angasetshenziswa nasezimweni ezinzima ze-ACO. La masosha omzimba e- monoclonal ahlanganisa i- omalizumab (i- anti- IgE antibody), i- mepolizumab (i- anti- IL- 5) ne- benralizumab (i- anti- IL- 5 receptor α antibody). Abantu abane-ACOS ne-eosinophilia baphendula kangcono ku-ICS; kunezimo ezingeziningi ezibi kakhulu nezibhedlela ezibonwe kubantu abane-ACOS abaphathwa i-ICS yesikhathi eside. Ama-corticosteroid ahlinzekwa ngomzimba (ama-steroid adluliselwa ngemithambo yegazi noma adluliselwa ngomlomo) angasetshenziswa uma i-ACOS ishuba. https://en.wikipedia.org/wiki/Asthma-COPD_overlap
- Ama-corticosteroid adonswayo - i- beta- agonist esebenza isikhathi eside (i- LABA) kanye nenhlanganisela ye- inhaled steroid (i- ICS- LABA) - ukwelashwa okuphindwe kathathu (ngamanye amazwi, ukwengeza i- inhaler esebenza isikhathi eside ye- anti- muscarinic (LAMA) - amasosha omzimba e-monoclonal abhekene nokuvuvukala kohlobo 2 - ama-corticosteroid ahamba ngegazi (ama-steroid adluliselwa ngemithambo yegazi noma adluliselwa ngomlomo)