Ii sheeg sida uu u shaqeeyo wareegga citric acid
Context:Wareegga citric acid (CAC) <unk> sidoo kale loo yaqaan wareegga Krebs, Szent-Györgyi-Krebs wareegga ama wareegga TCA (wareegga tricarboxylic acid) <unk> waa taxane falcelin kiimiko ah si loo sii daayo tamarta keydsan iyada oo loo marayo oksidheynta acetyl-CoA oo laga soo qaatay karbohaydrayt, dufan, iyo borotiinno. Wareegga Krebs waxaa isticmaala noolaha neefsada (oo ka soo horjeeda noolaha qallalan) si ay u soo saaraan tamar, ha ahaato neefsashada anaerobic ama neefsashada aerobic. Intaa waxaa dheer, wareegga wuxuu bixiyaa horudhaca qaar ka mid ah amino acids, iyo sidoo kale wakiilka yareynta NADH, oo loo isticmaalo falcelin kale oo badan. Muhiimadda ay u leedahay waddooyin badan oo kiimiko ah waxay soo jeedineysaa inay ahayd mid ka mid ah qaybaha ugu horreeya ee dheef-shiid kiimikaadka oo laga yaabo inay asal ahaan ka timid abiogenically. In kasta oo loo calaamadeeyay 'wareeg', looma baahna in dheef-shiid kiimikaadku raacaan hal waddo oo gaar ah; ugu yaraan saddex qaybood oo kale oo ka mid ah wareegga citric acid ayaa la aqoonsaday.  Magaca habka dheef-shiid kiimikaadkan waxaa laga soo qaatay citric acid (tricarboxylic acid, oo badanaa loo yaqaan citrate, maadaama qaabka ionized uu ku badan yahay pH-ga bayoolojiga) kaas oo la cuno ka dibna dib loo soo celiyo taxanaha falcelinta si loo dhammaystiro wareegga. Wareeggu wuxuu isticmaalaa acetate (oo ah qaab acetyl-CoA) iyo biyo, wuxuu yareeyaa NAD+ ilaa NADH, isagoo sii daaya kaarboon dioxide. NADH ee ay soo saarto wareegga citric acid waxaa lagu quudiyaa fosfooraynta oksidheer (gaadiidka elektarooniga ah) wadada. Labadan hab ee isku xidhka ah waxay keenaan oksaydhka nafaqooyinka si loo soo saaro tamar kiimiko ah oo la isticmaali karo oo ah ATP.  Unugyada eukaryotic, wareegga citric acid wuxuu ka dhacaa matrixka mitochondrion. In unugyada prokaryotic, sida bakteeriyada, oo aan lahayn mitochondria, taxanaha falcelinta wareegga citric acid waxaa lagu fuliyaa cytosol iyadoo gradient proton ee soosaarka ATP uu ku yaal dusha sare ee unugyada (membrane plasma) halkii uu ka ahaan lahaa xuubka gudaha ee mitochondrion.  Molekal kasta oo ah pyruvate (laga soo bilaabo glycolysis), waxsoosaarka guud ee xeryahooda tamarta ku jira ee wareegga citric acid waa saddex NADH, hal FADH2, iyo hal GTP.
Wareegga citric acid waxaa isticmaala noolaha si ay u soo saaraan tamar. Tan waxaa lagu gaaraa iyada oo loo marayo taxane falcelin kiimiko ah oo ka dhaca mitochondria si loo sii daayo tamarta keydsan iyada oo loo marayo oksidheynta acetyl-CoA oo laga soo qaatay dufanka, borotiinka, iyo karbohaydraytyada.