Iyini i-comparative genomics?
Ingqikithi yokuhlaziywa kwezakhi zofuzo okuqhathaniswayo ukusungulwa kokuhambelana phakathi kwezakhi zofuzo (ukuhlaziywa kwe-orthology) noma ezinye izici zezakhi zofuzo eziphilayo ezahlukahlukene. Yilezi zindawo eziphakathi kwezakhi zofuzo ezenza kube nokwenzeka ukulandelela izinqubo zokuziphendukela kwemvelo ezibangela ukwehluka kwama-genome amabili. Inqwaba yezenzakalo zokuziphendukela kwemvelo ezisebenza emazingeni ahlukahlukene enhlangano yakha ukuziphendukela kwemvelo kwe-genome. Ezingeni eliphansi kakhulu, ukuguquka kwamaphuzu kuthinta ama-nucleotide ngamanye. Ezingeni eliphakeme, izingxenye ezinkulu zama-chromosome ziyaphindaphindeka, zidluliselwe ohlangothini, zishintshwe, zihlukaniswe, zisuswe futhi zifakwe. Ekugcineni, wonke ama-genome ahlanganyela ezinqubweni zokuhlanganiswa, i-polyploidization kanye ne-endosymbiosis, ngokuvamile okuholela ekwakhekeni okusheshayo. Ukuba yinkimbinkimbi kokuziphendukela kwemvelo kwe-genome kubeka izinselelo eziningi ezithakazelisayo kubathuthukisi bemodeli yezibalo kanye nama-algorithms, abasebenzisa ububanzi bezindlela ze-algorithmic, zezibalo kanye nezibalo, ezisukela ngqo, i-heuristics, ipharamitha ebekiwe kanye nama-algorithms okusondela ezinkingeni ezisuselwa kumamodeli we-parsimony kuya kuma-algorithms we-Markov chain Monte Carlo wokuhlaziywa kwe-Bayesian yezinkinga ezisuselwa kumamodeli okungenzeka.  Eziningi zalezi zifundo zisekelwe ekutholeni ukulandelana kokufana ukuze kunikezwe ukulandelana emindenini yamaprotheni.