<s>[INST] born with neuroblastoma stage 3, extensive chemotherapy and surgeries with adhesions and occasional small bowel obstructions, now 28, once a year a significant drop in white blood cells, then almost as if the body recharges itself and its fine. Would this be related to the chemotherapy? OR could it be some kind of blood disorder which the doctors aren t catching? Happens every year, but cant find a reason or connection [/INST] Hi, how many time have you experienced drop in white blood cells? can you please mention what component of white blood cells mainly decreased? you have been treated successfully for the disease. now surgeries may be responsible for adhesions causing intestinal obstruction but yearly leukopenia ( drop in white cells) is not very common. you should be screened for other disease. autoimmune disease, lupus, infections like brucellosis also can cause leukopenia. bone marrow exam may be necessary. consult your physician. </s>