<s>[INST] Hello doctor, my brother had fever 7 days ago. He took many antibiotics (augmenten, ceftriaxone) and antipyretics but the fever come again. widal test was done and salmonella typhi O is positive titre 1/160 and salmonella typhi H is positive titre 1/80. also Liver enzymes ALT and AST were testes and they were very high (216 and 144).what should we do? [/INST] Hi The above stated test result is suggestive enteric fever, but if the test is done with rapid slide method then it should be repeated again with the tit ration method   increase level of Liver enzyme is nothing to worry in infective state of body this enzyme tend to increases, initially your brother had been given antibiotic erratically which brings drug  the resistance among the bacteria this is mistake done, now he should be given floroquinolones  (ofloxacine 600mg twice a day) along with the chloromphenicol  500 mg thrice a day for six days keep good hydration state . Get well soon </s>