<s>[INST] my husband has a painful knot on the top of his mouth.  as described to me, it is very hard, painful, size of a peanut and is located between the back of the roof of his mouth and his throat.  he is 43, 6'2", 220 lbs., a long term smoker with a history of drug abuse. [/INST] Hello! Read your query.I suggest for a biopsy of the tissue immediately. A oral pathologist can help you with this. The diagnosis and treatment can be based after biopsy result.QUIT smoking immediately and maintain a proper oral hygiene.Reduce consumption of spicy foods.Regards. </s>