<s>[INST] I have a small patch of water blisters on the shaft of my penis about a 1/4 inch in diameter. this is the second time I ve noticed them. The first time they went away in a couple of days and now there back after about a month. What could they be. I do not have or ever had multi partners. [/INST] HelloThanks for your query,based on the facts that you have posted it appears that you have blisters filled with clear fluid over shaft of penis . these are likely to be due to Herpes 2 viral infection transmitted through sexual intercourse with   female partner having HSV 2 viral infection .Though you do not have multiple partners one  can HSV 2 infection with a single partner who has dormant HSV 2 infection.Please get swab test of a fluid from blister and screenig test done to rule out HSV  infection.Dr.Patil. </s>