<s>[INST] Hi. I am wondering if you have much information on /donepezil and memantine efficacy in severe alzheimers disease. Mom has already lost most of her ability to perform daily functions. We are wondering if it is doing any good or may as well discontinue and not have whatever side effects may be occurring? [/INST] Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.Yes, Donepezil is a  cholinesterase inhibitors which is very effective in Alzheimer's disease.Hope this information would help you.Please consult your doctor regarding this.Thank you </s>