<s>[INST] Hello doctor, My father had a valve replacement last year, and he is currently taking Sintrom. He recently got prescribed Nystatin for oral candidiasis. He would like to know if he swallows it or by accident swallows a bit, can it interact with his medication or cause him a cardiac problem or a valve problem? [/INST] Hello, I passed carefully through your concern and would like to explain that Sintrom (Acenocoumarol) Nystatin do not show any adverse interaction when taken in the same patient concomitantly. Nystatin taken orally has poor intestinal absorption and could not reach the circulating blood in sufficient amount potentially interact and produce adverse effects. No cardiac issues will arise from that. I hope to have clarified your concern. </s>