<s>[INST] can you explain "mild cortical brain involution seen in the form of widening of the cortical sulci, especially in the parietal regions" there is periventricular white matter ischemic change, there is no evidence of intracranial haemorrhage or space occupying lesion or significant mass effect. my 81 year old mother's CT head scan . [/INST] Hi, mild cortical brain involution is due  to age related brain atrophy.With age ,  Our brain shrinks , Sulci and gyri become more prominent,  Ventricles become dilated and there is peri ventricular ischemia. So in short these are normal changes normal for 81 yrs of age. nothing to worry. Thanks </s>