<s>[INST] Hello, I have been treated for a macroprolacinoma over the past year. At first my levels were at 1300! They are now down to normal, however I have naturally lost around 20 pounds over this time. I take cabergoline 2 times per week 1/2 a pill. Is this weight loss alarming or is it most likely caused by the normalization of the prolactin in my body? All of the weight loss started after I received treatment. Also I am a type 1 diabetic in good control. [/INST] Hi, Thank you for posting your query. Prolactinoma with increased prolactin levels may be responsible for weight gain in some cases. Treatment with cabergoline (dopamine agonist) would result in normalisation of serum prolactin levels along with weight loss. So, there is no need to worry about your weight loss. Please get back if you require any additional information. Best wishes, Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) Senior Consultant Neurologist Apollo Hospitals, Hyderabad, My personal URL on this website:   My email: drsudhirkumar@yahoo.com </s>