<s>[INST] I have a fungal rash behind my knees.  It developed last June, but went away with treatment of Ketoconazole Cream 2%.  This time, the Ketoconazole doesn't seem to help.  My doctors said to try Nystatin Cream, but that seemed to make it worse.  What should I do? [/INST] Hello,Thank you for posting on HCM.It seems you are suffering from Tinea corporis, a kind of fungal infection.Fungal infections need proper treatment otherwise they keep on recurring.I usually recommend proper course of oral anti-fungal drugs like Fluconazole along with anti-fungal cream like luliconazole for local application at bedtime.You can additionally use antifungal dusting powder containing sertaconazole during day time and a soap containing ketoconazole for rinsing of affected areas. Take oral antihistaminics for itching as required.Maintain hygiene over those areas and avoid wearing tight undergarments.Hope your queries are resolved and wish you best of health.Thank youDr Hardik Pitroda </s>