<s>[INST] I have a friend that takes: carvidolol, furosimide k-dur, niphipine calcitrol, creator,novalog, LevimerShe takes nothing with food a d usually eats hours after taking meds. She has kidney disease, acid reflux, getting ready for surgery next week, lost a significant amount of weight in about 2.5 monthsDiabetic, hypertension etc. Advice for her [/INST] Hello, Thanks for the query.If a person has uncontrolled blood glucose (hyperglycemia), then, a considerable amount of glucose is lost from the urine as kidneys are not able to reabsorb it. Persistent loss of blood glucose through urine does lead to weight loss as well as persistent weakness and tired feeling. Since she has chronic kidney disease, which also is a possible complication of diabetes only and hypertension which again contributes to kidney disease. In such situation it is very essential for her to achieve a greater level of glucose control. That will help in controlling kidney problem. Even for better outcome of the surgery strict glucose control is absolutely necessary. Off course during surgery and post -operatively for a short period she will be on Insulin for better glucose control. But later again strict glucose control is a must. Thanks. </s>