<s>[INST] for 5 month old girl baby, doctors saying that cortico meddullary differentiation is lost and there is a increase in renal parenchymal echogenicity.can you please tell me is it danger for baby and please suggest me what is the treatement for this. Hi, may I answer your health queries right now ? Please type your query here... [/INST] Hi, It means that there is chronic kidney disease going on and that she will require regular follow up with a pediatric nephrologist. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Sumanth Amperayani, Pediatrician, Pulmonology </s>