<s>[INST] I am a privately contracted care giver. My patient has been diagnosed w/ drug overdose induced schizophrenia. He has been on Abilify and Seroquel for 6 mos and is showing no improvement. I find it difficult to believe that ANY drug regimen could reduce ,much less reverse the effects of my client frying his brain on just about every illegal substance known. He has CONSTANT violent voices and hallucinations. ie. I am having difficulty trusting his psychaiatrist [/INST] Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. From the available description it appears that your client is suffering with treatment resistant schizophrenia (Schizophrenia which fails to respond to two or more medications despite trial of adequate dose and duration).In such scenario Clozapine is the best suited option as it has shown efficacy in treatment resistant schizophrenia. In my opinion you need to discuss option of clozapine with his psychiatrist as next course of action. Hope I have answered your query. Let me know if I can assist you further. </s>