<s>[INST] I have read that the drug Dyazide can increase the symptons of patients with lupus. I have lupus and have been taking this drug for 15 years. At the same time I have been having a hard time keeping my lupus under control Is it possible that this drug is part of my problem? Thank you. [/INST] Hello.  Dyazide can cause cutaneous lupus but not SLE.That said, if the SLE is affecting kidney function, the Dyazide could worsen that problem </s>