<s>[INST] I am 41 year old woman who has been taking Venlafaxine 75 mg/OD since May 2012. The medication helped me with Major Depressive, Anxiety attacks and severe PMS disorder initially for a month or so after that I seem to fall back to my previous state. I am unable to get in touch with my primary or a specialist. Is it alright for me to increase the dose to 150 mg/BD. i am also Dx with Hypothyroidism and take Levothyroxine now at dose of 50 mg/OD. I was taking armourthyroid 60mg/OD but cannot find that medication hence the change [/INST] Hello and welcome to Healthcare Magic. Thanks for your query.Increasing the dose of your antidepressant Venlafaxine from 75mg OD to 150mg BD is a drastic increase and may have adverse effects like increased anxiety, agitation, drowsiness, etc. I would advise you not to alter the doses of your medication without consulting a doctor. You can try some relaxation exercises and deep breathing for your anxiety and try to meet your doctor as early as possible.Wish you all the best.- Dr. Jonas Sundarakumar  consultant Pychiatrist </s>