<s>[INST] My husband was diagnosed with small fiber neuropathy about 4 1/2 years ago and has been on 100 mg of Lyrica twice a day. He suffers from severe joint and muscle pain and spends most days in a recliner. No one seems to know what the problem is. Could Lyrica be the cause? [/INST] Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Yes in few patients may develop muscle pain and tenderness , muscle twitching and ,  jerking . If you develop above symptoms please consult your doctor he will examine and treat you with alternate medicine like Gabapentin or carbamazepine or valproate etc. Hope I have answered your query. Let me know if I can assist you further. </s>