<s>[INST] hello doc, i am using a gel named retino ac*(tretinoin 0.025% w/w and clindamycin 1% w/w gel). i am obsevring a peeling kind of thing on my skin.., it has become ruff just the way skin becomes in winter, it is also causing a bit of burning sensation and i feel the pimple marks on my skin have increased. could u plz tel me wht's wrong,i am very much worried. [/INST] hi   You are using tretinoin and clindamycin ,,this is a combination which is very effective in acne and is very frequently prescribed by dermatologists...But the problem is that proper application of this topical medication is very important..It has to be applied only at nightVery little amount has to be applied,,and it should not be rubbed onto the skin,,,The cream should only be touched over the affected area.Now in your case, you have developed irritant dermatitis .Firstly, you should stop using it for the time being.. Use a mild topical steroid like hydrocortisone over the affected areas twice a day for 4-5 days or till the time the redness and irritation subsides.And use an oil free moisturiser regularly over your face to decrease the dryness of skin,,,Also use a sunscreen (spf>26) regularly over your face before going out in the sun..Once the irritation stops, then you can use simple clindamycin gel over your face over the acne lesions twice a day..Hope it helpsDr Geetika Paul </s>