<s>[INST] i am a doctor,recently one young female with a background of bronchial asthma came to me with an injury at right great toe,that great toe was inflammed with feautures of infection,i gave her aceclofenac paracetamol combination,along with amoxycillin clavulinic acid combination.her finger status improved dramatically,but she developed bilateral pedal oedema with  facial puffiness,with normal urine output--------what could b the cause of such swelling and what to do now? [/INST] hello doctori read your question and understand your concernas you mentioned that your patient is already an Asthmatic patientso in Asthmatic patient don't ever give NSAIDs!as you given aceclofenac so this all because of this NSAID allergyi would suggest to immediately stop his NSAIDs and do one RFTs and give her anti allergic i/v and if there is breathing difficulty give Hydro cortisone 100 mg i/v and advise one chest x-ray PA view and treat accordingly i hope my answer will satisfy yougood luck & tc </s>