<s>[INST] My pregnant wife went to antental clinic for check up and she was confirm both VDRL and TPHA positive. She was given PENINCILLIN Iinjection so as i . Althouh i was tested negative. We got 3 dosages each for 3 weeks. we doubled cheched and am still negative and my wife is vdrl positive and TPHA reactive. What would be the most possible tretment to get away with this on going problem?. Thankyou [/INST] Penicillin is the most effective drug for the treatment of syphilis in pregnacy and you both have been given the right treatment .You need not worry as both TPHA and Vdrl continue to remain positive after treatment. You need to undergo quantitative assessement of vdrl after every 3 months as its titres fall  fourfold within 6-12 months of treatment. </s>