<s>[INST] For several months now I have had a horizontal red line across my toes & swelling in the toes. Some of my toe nails have fallen off. I have seen my family a Dermatologist & 2 separate Podiatrist. Taken antibiotics, used several different types of foot creams without success. I had a culture which didn t show any type of fungal infection. I am a healthy 52 yr old female. I take vitamins, phentermine, and a hormone compound specifically mixed for me. No history of heart disease, high blood pressure or diabetics. Some of my toes are very swollen, and even bleed? Any idea what could be causing this? [/INST] In my opinion you need to see a good orthopedic doctor IMMEDIATELY as you are describing onset of gangrene which may unfortunately require toe amputation if i were your doctor i will suspect osteomyelitis  (bone infection )MRI is needed to confirm also doplar should be done Really sorry but i must be honestGood Luck </s>