<s>[INST] My daughter suffers from mild depression for 1.5 years after her separation and is now having a major depression which is triggered now by work stress. She was started on Wellbutrin SR 150 mcg for 3 weeks. Then Doc switched to Effexor X R 37.5 mcg 2 tablets for the last 3 weeks but it has not helped her significantly. She has lost 8 pounds in the last 3 months. How long will Effexor take to work or should she try another medication. [/INST] Hai *Get a Physician opinion & rule out any comorbid medical cause *Antidepressent will take minimum of 2-3 weeks to show some change from baseline .It will take atleast 6 weeks to show significant improvement. she may require to continue Antidepressent for atleast 6-9 months in case Depressive episode is diagnosed. </s>