<s>[INST] I noticed my ankle starting to swell yesterday but thought nothing of it cause I haven t had any injuries , but this morning I could barely put on my shoe , it s huge. It doesn t hurt or anything just really uncomfortable to walk on. What could cause my ankle to swell like this overnight and Could this be dangerous or life threatening? [/INST] Hi, You should investigate for sudden swelling over a foot. Hypoproteinemia, liver malfunction, cardiac problem, kidney disease etc can be the reason for that. For that, I suggest you investigate with SGPT, SGOT, EKG, urea, creatinine estimation, serum protein estimation for further work up. According to cause specific treatment given. You should consult a physician for examination and discuss all these. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Parth Goswami, General & Family Physician </s>