<s>[INST] my sister 47 had gallbladder stage 2 cancer, had surgery done and after 1 year she got liver metasis, she is now at the hospital, cause had an infection of the bile, a stunt was placed to drain infection, she had received 2 types of chemo for 3 months, but did not work Now taking Tarceva and should start pallitive chemo once she is better stage.  My concern is that she is retaining fluid her belly is swollen, her ankles pratically all over.  Is there anything that can be done, what does this mean for her life. She is not taking any other medications.  She is strong and she is positive on all this.  Would she be a candidate for liver transplant. Tks Vicky [/INST] 1) palliative chemotherapy is for stage-4 cancers where there is no any other treatment option is available to cure cancer. purpose of it is to relieve symptoms of patients and to improve quality of life. palliative chemotherapy is not better stage.2) gall bladder cancer with liver metastasis is aggresive disease. it might affect liver function (formation of new proteins) depending upon spread of liver metastasis. symptoms of fluid in belly, ankle swelling suggest less protein in body.3) she is candidate for palliative chemotherapy (but consider location and spread of metastasis in liver) </s>