<s>[INST] If you have liver metastases colon cancer and are almost at the end of your chemotherapy treatment that does not resolve in getting all of cancer in the liver, and from what the oncologist says, it may not be able to be totally removed by surgery, what are the alternative options, if any and the prognosis if not. [/INST] Hi,Thanks for writing in.There is stage 4 cancer in the above case. The colon cancer might spread to the liver in half of patients during or after chemotherapy. It is important to know the number and size of liver lesions. A single lesion might be further treated but multiple lesions have low response rates to treatment.Since the oncologist has told that surgery is not possible therefore I consider the lesions to be multiple and difficult to be operated up on. There are techniques like radiofrequency ablation and trans arterial chemo embolization which might not work for every patient. The prognosis is difficult and survival might be 2 years in most of the patients with colon cancer and having liver spread. Please do not worry. </s>