<s>[INST] I am a 47 yr.old female. I am 5 2 and around 140 pounds. I take a low dose Lasix tab in the morning and Spironolactone 25 mg. twice daily. My blood pressure is 118 over 80 but my pulse rate is running around 85. I m concerned about the high pulse rate but also whether or not I should take my evening Spironolactone . I don t want my Bp to go any lower. [/INST] Hello,Brief Answer: Your blood pressure readings are good, no need to take the spironolactone evening dose. The heart rate of 85 is accepted.Explanation: My opinion is that the normal heart rate is from 60 to 100,  increasing or decreasing according to physiological conditions such as stress or sleeping. Some times we need heart rate to be resting at 60 in some patients such as an ischemic patient. If you are not ischemic, your heart rate of 85 is accepted. All diuretics should be taken during the day and it is not recommended to take it during the night as it would bother you going to the bathroom all night long.I suggest my patients the following: Maintain good hydration, salt restriction and follow up lower limb edema. The information provided by you is not sufficient to provide a good opinion. If someone comes to me with this condition I would ask them about the diagnosis and other comorbidities.Conclusion: I suggest you as for heart rate,  nothing to worry about, do take a night dose of spironolactone and check with your physician.Hope I have answered your query. Let me know if I can assist you further.Regards,    Dr. Mahmmad Gamal </s>