<s>[INST] Hello, one week ago my boy(22 years old) had abdomen ache.We went to a hospital. They found that esr (35) and kreatinin (4.0)is high. Kreatinin decreased gradually after one week  to 1.6. The doctors said that it may be from pain killer(majezic). Every check-up has done but nothing find. There is still  abdomen ache. [/INST] Hi.Thanks for your query. Understood that your son is still having pain in abdomen in spite of treatment and Creatinine coming down from 4 to 1.6.This is a good sign of recovery in kidney disorder. Repeat ESR reading to see the prognosis, it is good if ESR is also reduced. Yes, the painkiller Majezic can cause deranged kidney functions.The cause of the pain in such a case can be due to the following reasons:Due to high creatinine in the blood the intestines may not be moving in the correct speed and causes partial paresis of the intestines causing stagnation. Since the body tries to push the contents forward, the spasms thereupon can cause the pains. Secondly, this all predispose the intestines to more intestinal infection which in turn can cause pain in abdomen. I would advise you the following :CT scan of the abdomen after kidney functions reach the normal levels.Till then ultrasonography, a course of an antibiotic which does not disturb the kidney function. </s>