<s>[INST] My 15 year old son has been sick for over a year. He has a ton of thick mucous in his lungs and airways - found on bronchoscopy. Also tested positive for Streptomyces from bronchoscopy cultures. He has asthma but asthma meds are not working. Steroids not working. Cant figure out why he is so sick and cant get better. His infectious disease specialist suggested he should be treated as if he has cystic fibrosis even though his CF test is negative. Don t know what to do [/INST] Thanks for your question on HCM. In my opinion your son is having bronchiectasis. In this disease patient has thick, copious secretions, coughing all the time with wheezing and shortness of breath.So better to get done HRCT (High Resolution C T ) for the diagnosis of bronchiectasis. Try to follow these steps.1. inhaled bronchodilators.2. Pulmonary rehabilitation with chest physiotherapy and deep breathing exercise. 3. Expectorant and mucolytics.4. Pulmonary vaccination with pneumococcal and h.influenza to prevent future infections. </s>