<s>[INST] I am being tested for auto-immune disorders as I tested positive for ant-nuclear antibodies and recently had an xray done and a 5 cm lesion was found on my upper arm bone, with sclerotic properties.  I am having an MRI done in a week.  Could this lesion be the cause of my upper body pain, soreness and severe fatigue, or could it be the by product of an underlying disorder?  I have pain in other areas, such as my left elbow but the xray was normal. [/INST] HiPositive ANA doesn't necessarily mean auto immune disorder unless confirmed by further other tests.Body ache,soreness fatigue,maybe part of this underlying auto immune process if active and upper arm humerus bone sclerotic lesion may be isolated,not related to cause body symptoms.Consult a orthopedic doctor also.A bone scan of humerus may reveal if it's part of some marrow infection or osteomyelitis or just a part of connective tissue disorder.This </s>