<s>[INST] I have a perianal fistula that resulted in an abcess that burst 2 years ago was treated with heavy antibiotics went away but returned it raises and goes away reappears they give me sulpha for the symptoms. I recently tried the natural rout coconut oil, manuka honey and turmeric swelling has gone down feels better but I take losartan and metropal for high blood pressure vitamin d, calcium zinc and magnesium is there an interaction I feel extremely tired and have sinus infections a lot diagnosed with colitis 30 years ago. thanks [/INST] Hi,Having chronic fistula in ano is a big problem.With no medicine either alopathy or any hoe remedy is going to cure.It require skilful surgery to drain all sinuses opening into rectum.Even one sinus remained, risk of recurrence is very common.Consult surgeon and get examined.Ok and take care. </s>