<s>[INST] Hi, I have hypertension and currently I am having Ditide once a day, and Covance-50 twice a day. Ditide was introduced by my doctor uncle since I had BP on the higher side. Prior to this I was having Covance-D in the morning and Covance 50 in the evening. [/INST] Hello. Thank you for your question and welcome to HCM. I understand your question. Maybe it is a point of view of your doctor's. I would not go on and disagree with his prescription, since it is not wrong and it is helpful in treating the high blood pressure. Covance-D is a combination of a angiontensin receptor blocker (losartan) with a diuretic drug (hidrochlorthiazid). Whilst, Dytide is a combination of two diuretic drugs. I would share my and my clinic's experience: I would recommend as a first line of treatment for hypertension a beta-blocker (e.g. atenolol, metoprolol), because they also have a significant effect on lowering the heart's workload. If you are suffering from a condition related to the bronchi/lungs, where most beta-blockers are counterindicated, then you should use calcium channel blockers, such as verapamil or diltiazem. If the blood pressure figures would be still high (i.e. systolic > 140 mmHg and diastolic > 90 mmHg), then my opinion is that an addition of an angiontensiogen converting enzyme inhibitor (ACE-I: captopril, enalapril, lisinopril) drug would be in order. The addition of other drugs or drug classes to the therapy would be in order, if the blood pressure figures would keep being higher then the figures I provided above. I hope I was helpful with my answer. Best regards. </s>