<s>[INST] sir hi  i hope all fine at ur end . sir some time my bp goes up to 140/100. No heart problems found in tests but my doctor has advised me to take 1* 75mg  loprin daily and 1 * tablet of 50 mg Co-eziday. sir what are the timings to take these tablets like evening or morning. please guide. secondly both tablets are required or one out of these as both have the same effects. i want that one tablet one day and the other tablet next day. please let me know. thanks [/INST] Thanks for contacting HCM. Dear patient please understand that both these tablets have different functions. Loprin is low dose aspirin( a blood thinner) and should be taken at bed time. Co-eziday contains two antihypertensive medicines to control your B.P, one is losartan and other is  hydrochlorothiazide. Ideally antihypertensive if taken once a day should be taken at bed time but hydrochlorothiazide is a diuretic and will disturb your sleep due to frequent urination,so you should take it in morning as soon as you get so that diuresis gets over by the time you are ready for office. As both tablets have different functions there is no question of taking them on alternate day. Regards </s>