<s>[INST] Thanks, I have been taking pioglit/met 15-850 twice daily for a few years with a am fasting sugar between 100 - 120 . My doctor retired and my new doc told me there had been som neg imfo with pioglit so he changed med to glipizide er 5 mg one time and a 1000 mg meteor in one time daily and my am sugar have been between. 150 to 200. I don t go back for 2 1/2 months . Do you think I should call and as him about the differance in the dosage. Thanks..... David [/INST] Hi,Thank you for asking your query on HealthcareMagic.I have gone through your history. Your doctor is right. Pioglitazone class of drugs have been found to have some serious side effects. Glipizide and Metformin are good drugs to take care of your diabetes. However, based on you AM sugar levels, it seems you need a revision in your dosage or addition of another anti-diabetic drug. Kindly consult your current doctor for the same. Also, lifestyle changes are equally important with right medications. See you are having the right diet and regular exercise (at least brisk walk for an hour daily) for better results.I hope I have answered your query. Let me know in case of any further questions. Best,Dr Vishesh </s>