<s>[INST] Head and chest pains  I have sickle cell disease  and I keep having sharp pains in my chest in my head I'm wondering if he has anything to do with my sickle cell.... I been having these pains for the last four or five days... when I have the pain in my chest feels like I'm kinda having a heart attack that's how bad pain is...  what could be the problem what could be wrong [/INST] Hi,Thanks for asking.Based on your clinical history and query, my opinion is as follows:1. It appears to be related. It could be a condition called as acute chest syndrome.2. Chest pain due to heart attack would be continuous. 3. Sickle cells could be causing multiple sites of ischemia leading to pain at different areas.If sickle cells are high, red cell exchange might be necessary.Any further queries, happy to help again. </s>