<s>[INST] Hello doctor, I am wondering if anyone would know what is wrong or what other tests can be done. My ANA is 1:360, TSH is 0.5, free and total, T3 and T4 are normal. SLE (systemic lupus erythematosus) is negative, Sjorgen's is negative, and thyroid ultrasound is normal. Symptoms experienced are extreme fatigue, weight gain, inability to lose weight, hair loss, not in patches but thinning extremely, loss of energy, extreme dizziness, sometimes loss of sight, constant migraines or headaches, swollen feet and ankles, frozen hands and feet all the time, neck feels swollen or thicker, chronic hives, and dry skin. [/INST] Hello. I went through your post. Firstly, let me summarize your complaints and investigations. I would, as a rheumatologist, first look whether there are clinically any features of vasculitis because high eosinophil count can occur in vasculitis or in helminth infestations. So, you need to do an ANCA (antineutrophil cytoplasmic antibodies), both C-ANCA and P-ANCA, to look for ANCA-related vasculitis. You need a spot urine protein test to see whether there is any proteinuria or active sediment in the urine. ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein) will tell us if there is any inflammation or not. For the time being, you should take an anthelmintic, preferably tablet Albendazole 400 mg single dose. For more information consult a rheumatologist online.--> </s>