<s>[INST] she was diagnosed w/ group A beta hemolytic streptococcal infection that led to the development of acute glomerulo nephritis How did this progress from throat infection to renal desease I have an 11 year old girl who is in end-stage renal disease . I am very confused and frightened. My husband asks the staff how this could have happened his little girl. The events leading to this situation began, and desires to learn more about how his daughter has diminished to the point of needing a kidney transplant. We we ask them how this all began, we were informed our daughter had a group A beta hemolytic streptococcal infection that led to the development of acute glomerulo-nephritis. We just would like for someone to explain/describe to us the progression from a simple throat infection to renal desease? PLease help us [/INST] IT IS BECAUSEW OF THE AUTOIMMNUNE PROCEESS. BETA STREPTOCOCCI CAUSES ANTIBODIES AND THE BACTERIA CAN DAMAGE THE KIDNEY MEMBRANE CALLED BASEMENT MEMBRANE AND THEN ONGOING DAMGE BC OF THE SELF DEFENSE MECHANISM TURNED ON BY THE BACTERIA ,MORE YOU CAN READ AT THE ET BY ANTI GBM DISEASE WISH HER HEALTH TC </s>