<s>[INST] My wife a 50 year old lady has severe pain of  joints( wrist, thumb, shoulder etc.),but no apparent inflammation. .Recently  she went to a neuro physician who has adviced a few drugd including Depof 37. What can be the reason for prescribing Depof 37. [/INST] Hi, I had gone through your question and understand your concernsDepof 37 is anti-depressant drug.I think that your doctor prescribed it to relieve mental stress as it may aggravate your pain.With such presentations in my clinic, I would first rule out any cause for arthropathy by ding the following investigations(CBC,Rheumatoid factor,ESR,CRP,ANA,serum uric acid). </s>