<s>[INST] Dear doctor my name is neda I have a sister. She is 23 years old. She has hair growthing problem on her head since 15 years. In first years of her life, her hairs were dense but suddenly  they began to downfall as the skin of her head can be seemed. This matter is in between her brow and top of her head like a semicircle. The skin of this area is red, hot and painful as nobody can touch her hairs or head because of pain. When her hairs began to downfall, she went to many doctors and they asked her many tests for many bool indicators, many kinds of hormone tests with many indicators but all of them were normal and are normal still. I want to add that the talons of my sister both in her hands and in her foots are very strong and they can not stave easily. When the doctors can not found any unnormal thing in her tests, so they gave her many kinds of vitamins like fefol, zinc plus, multi daily, normal zinc, B pantine, farmaton, sanostol, neurobion, and many kinds of other vitamins that I can not remember their names. Also they gave her many kinds of lotions and many kinds of shampoos with chemical and herbaceous materials but they were not useful. One of last doctors gave her, a neurologic drug with fluoxetine name that it can lessen the pain of her head and skin of head but it can not help to grothing her hairs as it is a neurologic drug. Also I want to add that her hair filaments are very squatty but when they are growth for 5 cm, they begin to downfall. Her monthly period is regular and she has not any volume in her cysts or she has not any putrefaction in any place of her  body and we have not any person like her in our family as genetic. Her weight is 55 kg and her length is 160 cm. she has some worries in her life but they are not unusual. She is single. Really she is very sad about her hairs and she can not go any where, Would you please help us about this matter? Looking forward for your kind helps. Best regards Neda [/INST] Hello, I suggest you use Minoxidil 5% solution, 1ml,  twice daily. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Kakkar S., Dermatologist </s>