<s>[INST] I AM on Doxepin, and used to be on Zoloft. Can both meds be taken together? I suffer greatly from PTSD and have a bad case of Agoraphobia. I never leave the house anymore. I have the V. A. nurse do all my shopping. I want to go to Church but lost my right leg in an accident and the chair makes a loud noise coming in Church so I stopped going as when I entered everyone would stare. Or so I felt. I have a Psychiatrist and a Psychologist I see at the V. A. but it s been a while. My meds are renewed every 6 months after a short visit. [/INST] Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. I can understand your concern. Doxepin is a TCA drug and Zoloft is a SSRI drug. Its not advisable to use Doxepin and Zoloft in high doses together. But in therapeutic doses under guidance of psychiatrist these drugs are safe together. Doxepin will help to supplement the actions of Zoloft and will help to treat the difficult to treat anxiety symptoms. So yes its safe to take Doxepin and Zoloft together. Hope I have answered your query. Let me know if I can assist you further. </s>