<s>[INST] Hello...my mother is 81 with multiple myeloma and is on Revimed. 21 days on, 7 days off. she has side effects, diahriah (spelling?), constipation, etc. How long does Revlimed stay in system...is it possible that side affects will continue during week off meds? [/INST] The 7 day gap is given to allow the body to recover from the side effects of the drug and not to allow the drug to go out of the system. Diarhhoea is a common side effect of the drug and is normally not worrisome. If it is excessive you can try giving Tab loperamide at bedtime. Else, you might have to discontinue the drug in consultation with your oncologist. </s>