<s>[INST] my grandmother is on a morphine drip due to pancreatic cancer. She is in the last weeks of her life. The hospice nurse put a new site on her lower thigh. Now, on her upper thigh, she has a hard, tender, red lump; about the size of a fist... what is the cause of this [/INST] Hi. This lump is due to extravasation of blood out of the fragile vein .This is quite common. Just observe that there is sign of infection like redness and increased local temperature , too much pain even on touch.She may need an antibiotic and may be an aspiration by a needle. </s>