<s>[INST] I have always had normal AST and ALT reading and recently had a big jump up from normal to AST42 / ALT 40 in September to 58/88 in November and now 226/354 and 199/297 in two recent December tests. I had pneumonia following a trip to Turkey in July and have tested negative for hepatitis. Any ideas on why this sudden jump? Everything else is normal except high thyroglobulin antibodies. I also take 40mg of lisinopril daily and have a history of allergies and allergy induced migranes when I took allergy shots. [/INST] Hello. Thanks for putting your query in HCM.I can understand your concerns. Elevated liver enzymes suggest liver cell injury.There are many causes for elevation of liver enzymes like alcohol intake, Hepatitis B and C virus, wilson disease, autoimmune liver disease and drug induced. In your case it may be drug induced. For pneumonia I assume you have taken some antibiotics, lisinopril itsef causes elevation of liver enzymes. So I will suggest you to visit a gastroenterologist for evaluation and appropriate managementI hope I have answered your query and this will help you. If you have any further query  I will be happy to answer that too. Remain in touch and get-well soon. </s>