<s>[INST] My age 79 yrs average built, am on amlopress l in morning 0900 hrs,selokene xl 50 mg at 1700 hrs, minipress xl 2.5 mg at 2200 hrs, but my pr shoots up from 1600 hrs from 145-150 -85-90 to 160-170 -95-100 till 2300 hrs after that it gradually comes down and day time its under controll. worried about the rise in the evening,am old pt of diabetis on oha,recently had a stroke 02 months back, kindly advice am also doctor [/INST] Hello thereI feel you have a mix of too many short acting and long acting drugsI suggest an amopress-L twice a day at 8.AM and $ pm will take you through the daySeloken XL50 mg in the morning and perhaps another in the afternoon evening 4-5 PM should be enoughYou don't require Minipress XlPlease try the above combo and let me know. We need to tinker with your present drugs onlyHope that helps </s>