<s>[INST] Hello doctor, I have had three IVF failures. Latest failure -four embryos transferred, two -day 3, two -day 5 (blastocyst with array), negative beta hCG. I want to know the reason for the failure. [/INST] Hello. I am sorry that you had an IVF failure. The causes can be many, right from immature poor quality egg fertilization, inadequate endometrialization, inadequate post embryo transfer medical support, previous endometriosis or any subsistent pelvic or vaginal infection or a UTI, improper technique, implantation failure, poor initial ovarian response as in your case with poor AMH levels, life-style factors like smoking and drinking are also contributory to reducing chances of an IVF success. It is always best to treat and cover each factor before opting for this expensive procedure. Please share your reports and protocols or medicines offered during the procedure to evaluate and guide further. </s>