<s>[INST] Hi Doc. I have been taking Divain 50 tabs for acne for 6 months (my derma prescribed it). I just want to ask if it is safe to take it for so long and also how long should i continue it for? My acne have already subsided. In addition to that I have also been asked to apply - SunGuard 40+, Retinol , Benzoic 2%, and Tri O Bloc cream during different times. Please tell me how long should I continue the treatment for. [/INST] Hi, as such minocycline is a safe drug, does not cause much of antibacterial resistance so can be taken for long time but it is advisable to take it for 3 months only for acne as its an age related problem and for mild disease can be controlled with topical medication/. take care </s>