<s>[INST] from roxicodone 15 mg to fentanyl patch 50 mg my doctor recently put me on fentanyl patch 50 mcg/hr after taking roxicodone 15 mg for ablout a year but the patch is making me sick trwoing up,stomach pain,very sleepy,left arm felt asleep lots of tingling and dry pain is this safe?? [/INST] Hello, Any opiate often causes stomach sickness: opiates affect gut motility and cause constipation. Opiates cause gall bladder spasm, opiates directly cause nausea, opiates cause sleepiness even to the point of fatal overdose, opiate withdrawal causes stomach pain and throwing up. Cannot say in your particular case, and there are many many reasons how opiates affect gastrointestinal action and/or nausea. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr. Matt Wachsman </s>