<s>[INST] I have been diagnosed with primary aldosteronism and have been treated with Maxzide 50 mg which worked for a few months, then switched to sprironaldactone 200 mg daily - this has raised my postassium level which was low but has not helped with the fluid retension.  What do I try next? [/INST] In this situation you need combined diuretics like frusomide plus spironolactone. In general in primary hyperaldosteronism edema is uncommon. It's better to re-look at diagnosis.All the best. Avoid salt diet. </s>