<s>[INST] My wife is 50 year old and take ramipril 5mg to reduce the pressure on her kidneys she is diabetic and anemic with arthritic joints. When she take ramipril she suffers from all the uncommon reactions that are supposed to be rare approx 1 in 1000 people to 1in 100. Is there an alternative ACE inhibitor which she could take without any side effects? [/INST] Hi Welcom To HCM I have gone through your query regarding un comon side effects of Ramipril .Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, If you experience  if any of the following side-effects or any other symptoms  continue or become troublesome , stop taking ramipril and contact your doctor for advice straightaway:Any difficulty breathing, or swelling of your face, mouth, tongue or throat. These are signs of an allergic reaction.Any yellowing of your skin or whites of your eyes. These may be signs of jaundice which is a rare side-effect.A severe skin rash.Meanwhile , I may suggest you to Adopt regularity in your life style , without which  ,Gulping on medicines or pumping in shots  will not help much help .Many have been helped  with this regimen -Simple, healthy nutritious food including more of fibers , protiens , vitamins & minerals than starches like rice , potatoes . Also avoid tea ,coffee alcohol fried and fast foods PROPER regular EXERCISE , WALK, YOGA , pranayam -deep breathing proper rest HELP YOU TO STRENGTHEN YOUR IMMUNE SYSTEM and help you lead disease free life .Constipation should not be alowed to continue .Turmeric powder with a cup of hot milk befor bed time help many types of bacteria and sugar level under control .A Tspoon of fenugreek seed powder with water in the morning to control sugar level .Antioxidants like raw garlic ,ginger , onion in every meal .Use of lemon in water befor meals and  in lunch help the body keep going .All the above is full of antioxidendants having no side effects giving you immunity to live life without such disease and  go with any therapy . Condition is to be regular with this regimem .Hope this helps you in solving your query All the best . Take Care .Don 't hesitate to get back if have any further query </s>