<s>[INST] I have had psa annually since 2009 in 2010 my psa rose to 5.6 I was advised to see a Uroligist I have been under his guidance for the last three years. I also have had 2 biopsies the first one showed the beginning of prostate cancer the doctor said it was the most commom slow growing Cancer. the second biopsy was taken and it came back negative and he said I was cleared of cancer. since then we have been doing the waiting game, two weeks ago he found that I had prostatitis and prescribed an antibiotic, after the two weeks on the drug I had another PSA he told me it had raised slightly over the last two years my psa now is 8.4 he now wants to wait three months and take another psa and from that reading another possible biopsy. I am also taking metformin and Zoloft for other conditions can taking these medications cause my psa to rise? [/INST] HiThanks for your query.This rise in PSA is not due to zoloft or metformin but may be due to prostatitis or cancer. If this comes back to baseline, then you can wait, otherwise repeat biopsy will be required.Hope this helps,Regards </s>