<s>[INST] Hi. I am a renal transplant patient. I have had my transplanted kidney for 16 yrs. As of recently my creatinine levels are raising.. I believe it is due to the medication i take. I believe the meds are now becoming toxic to my transplanted kidney. I've researched post transplant patients getting off all meds. can you tell my why this is not something that is more common. I understandthe need for the immunosuppressant pills - but after this long wouldn't the transplanted kidney be "my own" at this point. My way of thinking is, the kidney now has my blood running thru it and has for years.. Would my body still try to attack it after this long? [/INST] HIThanks for your query.There is a risk of rejection of the kidney by the recipient's body at any point in the lifetime of the patient.So it is absolutely essential to continue the immunosuppression if we wih to preserve the kidney.If one particular pill is causing problem, speak to your nephrologist whether it can be substituted.Hope this helpsGood luck. </s>