<s>[INST] Why does a man who had hairy legs as a teenager/young adult suddenly loose all the hair on his legs, from his thighs to his ankles? I ve had hairless legs for over 35 years! I ve asked my doctor several times about it and he just shrugs his shoulders. [/INST] Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. As per your case history of hair loss on legs, my treatment advice is - 1. Don't scratch the lesion as it may worsen the condition. 2. Apply a Tacrolimus 0.03% ointment on affected part. 3. Take an iron supplement and vitamin B12 supplement. Hope I have answered your query. Let me know if I can assist you further. </s>