<s>[INST] History : Clinical diagnosis of liver , lest lobe mass . Gross : Received specimen consists of multiple pieces of gray colored tissue , soft in consistency , measuring 6 5 1.5 cm . on cut surface yellow , blak and gray solid areas are seen . Summary of specimen : 9/4 IHC staining results : -Hepar : Negative -CK7 : Negative - CD20 : Negative Diagno : Liver mass excision : Poorly differentiated carcinoma ( metastatic probably ) Note : For definite determination of primary origin and rule out of neuroendocrine differentiation IHC staining is necessary . Resident : Dr. NIK NIAZ do i have cancer or not [/INST] Hi, Liver metastasis is common with gastrointestinal primary cancer. Other possibilities are lung cancer, breast cancer. CK 20 negative result rules out colon primary, Ck 7 negative rules out Lung primary. Other possible markers are GCDFP for breast cancer.  In case of no primary tumor indentification, tumor to be called as CUP ( carcinoma of unknown primary) and to be treated with broad spectrum chemotherapy. Consult your oncologist. </s>