<s>[INST] I have suddenly gotten edema in my back, abdomen, thighs, calves, ankles. What is really weird is the swelling in my back and hips!  I have kidney disease. It was 26% one year ago, then improved to 36% this past may and the end of November improved to 40%. I'm worried this may have something to do with kidneys but I have other illnesses such as diabetes, hypothyroidism, orthostatic hypotension etc. I have tried drinking lots of water, drank prune juice, taken a prescription water pill.  This came on suddenly in the past 5 days. HELP! [/INST] hiconsult a nephrologist and get GFR and creatinine tests.For treatment freusomide  twice a day and restriction of fluids upto 1.5 litres only in a day. Get serum Na, K, CL, and bicarbonate levels done. Also blood sugar levels.uncontrolled diabetes can also lead to kidney damage.For hypothyroidism eltroxin is prescribed- consult your physician and get thyroid profile test,T3, T4,TSH levels.hypothyroid can also cause more swelling on bodyBest Wishes, </s>