<s>[INST] HiMy wife suffers froms bouts of uticariaWe know of some allergens related to food like peanutsBut even though she avoids this she still gets attacksIf she takes anti-histamines at the very immediate begining of an attack it generally is goes away withHowever at times it ends only after she vomits out the foodShe has gallstones and generally uticaria is followed by indigestionWould removing gallbladder help to reduce uticaria attacks?Thanks, raju [/INST] Hi,Thanks for using Healthcaremagic,Your wife has basically two health issues first one is Urticaria, and Gall bladder stones.Urticaria is allergic manifestation usually allergen may be more than one like you said peanuts is one if it is known she must avoid it.She should be investigated for Urticaria with Complete blood count, serum I g E level, stool R&M and allergy testing for various possible allergens.If specific allergens are found they can be avoided and even immunotherapy is possible.In many cases cause is unknown symptomatic relief is obtained by anti histaminic drugs take prophylactically.Her indigestion and gallstone may be associated but removal of gallbladder will not help in Urticaria.If she has pain consult surgeon regarding surgery of Gallbladder laparoscopic surgery if possible.Hope this helps.Take care.Good Luck.Dr.Akhilesh Dubey M.D. </s>