<s>[INST] I have fibromyalgia, and at night after I sit down for a while, I get the worst muscle cramps in both legs, especially in my thighs, and my right thigh is the worst. I can actually see the muscles twitch. I am already on a postassium supplement, so I know it s not that. I have tried the heating pad, but it helps only a little bit. Is there anything else I can do, or is there a vitamin or supplement that can help me? Thank You for your time. [/INST] Standard therapy is a nerve damper like robaxin, pregabalin, gabapentin or amitryptiline.Also, muscle relaxants perhaps anti-inflammatories.Stay the heck away from any narcotics in any formThere is no convincing way to differentiate fibromyalgia from depression so anti-depressants work in the vast majority.And exercise and ways of changeing one's relationship to movement activity and pain. </s>