<s>[INST] Hi, My age is 33, weight 77 kg, height 5 10 and blood group A+. My wife s age is 29, weight 59kg, height 5 6 and blood group AB-. We never smoke and drink. our medical history is normal. We are planing to have first baby. I want to know will there any complication due to age and our blood group mismatch? Do we need to consult some docto for this? I am not sure of the precaution and planning for the pre-preganancy. Please suggest the things (Diet,medicine etc) we have to follow for pre-preganancy phase. Thanks, Pawan [/INST] Hi,I don't seem to think there is a age mismatch 33 and 29 years are perfectly normal age to consider having children.Blood group of AB negative needs attention. Your wife will require anti D injections at 28 weeks of pregnancy and after delivery. Also if she has certain complications during pregnancy she may require anti D.Rhesus negative pregnancy usually do not cause a problem in first pregnancy, but if anti D is not considered and given in first pregnancy it can cause problem in the next pregnancy.In the pre-pregnancy, she should have healthy diet and lifestyle and also take Folic acid 400 micrograms daily till she gets pregnant and continue it till 12 weeks of pregnancy.She should inform her treating gynecologist about her negative blood group.Hope this helps.Regards. </s>