<s>[INST] this is for a Hepatologisti have a patient on pegasys for Hep C who has been having recurrent attacks of galls tone colics and needs a lap cholecystectomy. the patient has a Child A cirrhosis with portal hypertension. can I have the patient continue taking pegasys in the peri-op period?aabha [/INST] Hello! Thanks for putting your query in HCM. I am a Gastroenterologist. yes you can continue with pegasys in the periop or post op also. But three things you have to keep in mind:1. He is having Cirrhosis, Child'S A, so avoid hepatotoxic drugs and tell the patient about the risk of surgery2. Now oral medications (DAA-Directly acting antivirals) are available for treatment of Hepatitis c. You can switch him to that depending on the Genotype. 3. Universal precautionsI hope I have answered your query and this will help you . Wish you a good health </s>