<s>[INST] Hi ivebeen taking 150mg sertaline 200mg bupropion 25 trazadone for about 4 years now and sometimes I wonder if it just make things worse. I feel emotionless alot . I can t tell if its the meds are me. Can the mews I m on make me go numb from my emotions? I don t know what s worse feeling numb or crying all the time. [/INST] Hello,Thanks for choosing health care magic for posting your query.I have gone through your question in detail and I can understand what you are going through.Well its not the combination. Sertraline can causes such numbness and hence if your depression is well under control then sertraline can be better changed to venlafaxine or mirtazapine etc.Hope I am able to answer your concerns.If you have any further query, I would be glad to help you.In future if you wish to contact me directly, you can use the below mentioned link:bit.ly/dr-srikanth-reddy </s>