<s>[INST] My wife is suffering from mania and she has been prescribed with Lithosun SR 300 (twice a day) and Macorate 400 MG (Once a day). She has complained of passing urine very often, especially in the night time. Is there any solution to avoid this? And are these drugs something that she has to consume forever? OR is there a one-fine-day before all these are not required? [/INST] Among the medication she is taking lithosun may cause such problem. Single dosing may help if she  can tolerate. Duration of treatment depends on the severity of episodes, number and frequency of past episode, symptoms in between the episodes etc. </s>