<s>[INST] I am taking entecavir for 4 yrs , hbv dna became lower.  My Doc said if my anti hbe become positive, i have to stop taking enticavir anymore. pls. Explain if im in good health or not if anti hbe result positive or negative what woulb be the effect? thanks [/INST] HBE is hepatitis B E antigen. This HbE is the marker of active replication of hepatitis in the human body. If anti HBE arise in the body than your active replication of Hepatitis is halt. so you should stop taking the entecavir. so, do not worry you are in the good health state. thnx </s>