<s>[INST] iam suffering from mediastenal lymph nodes tuberculosis,i used Akt 4 for 2months now since one month on isoniazide and rifampacin,but the problem is iam suffering with weight loss,cough and mild evening rise of temperature ,do my problem reverting back? [/INST] Thanks for your question on HCM.I can understand your situation and problem.In my opinion you should get done repeat CT thorax to know the size of the mediastinal Lymphnodes.If size is decreasing then no need to worry much, you are improving.But is size is same as of previous scan or increased then possibility of MDR (multi drug resistant) tuberculosis is high.So you need endobronchial ultrasound guided (EBUS) biopsy and culture and sensitivity report to rule out MDR TB.So consult pulmonologist and discuss all these with him. </s>