amino-monosaccharide glucose arthritis osteoarthritis German
Glucosamine is an amino-monosaccharide that naturally occurs in all tissues, particularly in articular cartilage of joints and from the biosynthesis of glucose. Natural synthesis of glucosamine occurs in the extracellular matrix of articular cartilage in joints. However, as a result of damage to the joint or cartilage, there is decreased ability to synthesize glucosamine resulting in the deterioration of the joint, and supplementation is required. Clinical trials of long term administration of glucosamine in German Shepherds have reduced symptoms of degenerative joint disease and accelerated cartilage healing. Anti-inflammatory effects of glucosamine are believed to contribute to the reduction of pain, promote joint recovery and mobility, and prevent further cartilage degradation. Similarly, chondroitin supplementation is proposed to have comparable results in inhibiting degradative enzymes within the cartilage matrix to reduce the effects of osteoarthritis, but further research is required to assess long term benefits.
