In adjudging the question of prejudice the fact that the absence of a charge,or a substantial mistake in it,is a serious lacuna will naturally operate to the benefit of the accused and if there is any reasonable and substantial doubt about whether he was,or was reasonably likely to have been,misled in the circumstances of any particular case,he is as much entitled to the benefit of it here as elsewhere; but if,on a careful consideration of all the facts,prejudice,or a reasonable and substantial likelihood of it,is not disclosed the conviction must stand; also it will always be material to consider whether objection to the nature of the charge,or a total want of one,was taken at an early stage