风流军医俏护士 (电视剧)

Plot.

"M*A*S*H" aired weekly on CBS, with most episodes being a half-hour in length. The series is usually categorized as a situation comedy, though it has also been described as a "dark comedy" or a "dramedy" because of the often dramatic subject matter.  The show is an ensemble piece revolving around key personnel in a United States Army "Mobile Army Surgical Hospital" (MASH) in the Korean War (1950–53). (The asterisks in the name are not part of military nomenclature and were creatively introduced in the novel and used in only the posters for the movie version, not the actual movie.) The "4077th MASH" was one of several surgical units in Korea.  While the show is traditionally viewed as a comedy, many episodes had a more serious tone. Early seasons aired on network prime time while the Vietnam War was still going on; the show was forced to walk the fine line of commenting on that war while at the same time not seeming to protest against it. For this reason, the show's discourse, under the cover of comedy, often questioned, mocked, and grappled with America's role in the Cold War.  Episodes were both plot- and character-driven, with several narrated by one of the show's characters as the contents of a letter home. The show's tone could move from silly to sobering from one episode to the next, with dramatic tension often occurring between the civilian draftees of 4077th – Hawkeye, Trapper John, and B.J. Hunnicutt, for example – who are forced to leave their homes to tend the wounded and dying of the war, and the "regular Army" characters, such as Margaret Houlihan and Colonel Potter, who tend to represent patriotism and duty (though Houlihan and Potter could also represent the other perspective at times). Other characters, such as Col. Blake, Maj. Winchester, and Cpl. Klinger, help demonstrate various American civilian attitudes toward Army life, while guest characters played by such actors as Eldon Quick, Herb Voland, Mary Wickes, and Tim O'Connor also help further the show's discussion of America's place as Cold War war maker and peace maker.

Characters.

Main cast.

Through changes of personnel "M*A*S*H" maintained a relatively constant ensemble cast, with four characters – Hawkeye, Father Mulcahy, Margaret Houlihan, and Maxwell Klinger – on the show for all 11 seasons. Several other main characters departed or joined the program during its run, and numerous guest actors and recurring characters were used. The writers found creating so many names difficult, and used names from elsewhere; for example, characters on the seventh season were named after the 1978 Los Angeles Dodgers.

Production.

Writing.

As the series progressed, it made a significant shift from being primarily a comedy with dramatic undertones to a drama with comedic undertones. This was a result of changes in writing and production staff, rather than the cast defections of McLean Stevenson, Larry Linville, Wayne Rogers and Gary Burghoff. Series co-creator and joke writer Larry Gelbart departed after Season 4, the first featuring Mike Farrell and Harry Morgan. This resulted in Farrell and Morgan having only a single season reading scripts featuring Gelbart's comic timing, which defined the feel and rhythm of Seasons 1–4 featuring predecessors Rogers and Stevenson, respectively. Larry Linville (the show's comic foil) and Executive Producer Gene Reynolds both departed at the conclusion of Season 5 in 1977, resulting in "M*A*S*H" being fully stripped of its original comedic foundation by the beginning of Season 6 — the debut of the Charles Winchester era.  Whereas Gelbart and Reynolds were the comedic voice of "M*A*S*H" for the show's first five seasons (1972–1977), Alan Alda and newly promoted Executive Producer Burt Metcalfe became the new dramatic voice of "M*A*S*H" for Seasons 6–11. By the start of Season 8 (1979–1980), the writing staff had been completely overhauled, and with the departure of Gary Burghoff, "M*A*S*H" displayed a distinctively different feel, consciously moving between comedy and drama.  The end of the Vietnam War in 1975 was a significant factor as to why storylines become less political in nature and more character driven. Several episodes experimented by going outside the sitcom format:  Another change was the infusion of story lines based on actual events and medical developments that materialized during the Korean War. Considerable research was done by the producers, including interviews with actual MASH surgeons and personnel to develop story lines rooted in the war itself. Such early 1950s events as the McCarthy era, various sporting events, and the stardom of Marilyn Monroe were all incorporated into various episodes, a trend that continued until the end of the series.  While the series remained popular through these changes, it eventually began to run out of creative steam. Korean War doctors regularly contacted producers with experiences that they thought might make for a good storyline, only to learn the idea had previously been used. Harry Morgan admitted that he felt "the cracks were starting to show" by season 9 (1980–1981). Alda wished to make season 10 (1981-1982) "M*A*S*H"s last, but was persuaded by CBS to produce a slightly shortened 11th season, coupled with a farewell movie finale, at CBS' request. In the end, season 11 had 15 episodes (although six had been filmed during season 10 and held over) and a 2-1/2 hour movie, which was treated as five episodes and was filmed before the nine remaining episodes. The final episode produced was the penultimately aired episode "As Time Goes By". The series finale movie, titled "Goodbye, Farewell and Amen", became the most watched U.S. television broadcast in history at that time, with 106 million viewers.

Set location.

The 4077th consisted of two separate sets. An outdoor set in the mountains near Malibu (Calabasas, Los Angeles County, California) was used for most exterior and tent scenes for every season. This was the same set used to shoot the movie, although there were changes made to the positions of several tents for the TV show. The indoor set, on a sound stage at Fox Studios in Century City, was used for the indoor scenes for the run of the series. Later, after the indoor set was renovated to permit many of the "outdoor" scenes to be filmed there, both sets were used for exterior shooting as script requirements dictated (e.g., night scenes were far easier to film on the sound stage, but scenes at the helicopter pad required using the ranch).  Just as the series was wrapping production, a brush fire destroyed most of the outdoor set on October 9, 1982. The fire was written into the final episode as a forest fire caused by enemy incendiary bombs that forced the 4077th to move out.  The Malibu location is today known as Malibu Creek State Park. Formerly called the Century Ranch and owned by 20th Century Fox Studios until the 1980s, the site today is returning to a natural state, and is marked by a rusted Jeep and a Dodge ambulance used in the show. Through the 1990s, the area was occasionally used for television commercial production.  On February 23, 2008, series stars Mike Farrell, Loretta Swit and William Christopher (along with producers Gene Reynolds and Burt Metcalfe and "M*A*S*H" director Charles S. Dubin) reunited at the set to celebrate its partial restoration. The rebuilt signpost is now displayed on weekends, along with tent markers and maps and photos of the set. The state park is open to the public. It was also the location where the film "How Green Was My Valley" (1941) and the "Planet of the Apes" television series (1974) were filmed, among many other productions. Much of this location, including the signpost and markers, was thought to have been destroyed in the 2018 Woolsey Fire but subsequently was determined to have survived the fire.

Smithsonian exhibit.

The exhibit "M*A*S*H: Binding Up the Wounds" was at the National Museum of American History from July 30, 1983 through February 3, 1985. The exhibit was extremely popular, drawing more than 17,000 in a single week, a record for any Smithsonian display.  On exhibit were The Swamp and Operating Room sets, one of the show's 14 Emmy Awards, early drafts of the pilot script, costumes from the show and other memorabilia. Sets were decorated with props from the show including the iconic signpost, Hawkeye's still and Major Winchester's Webcor tape recorder and phonograph. The exhibit also encouraged visitors to compare the show to real Mobile Army Surgical Hospitals of the Korean and the Vietnam Wars. Radar's teddy bear, originally found at the ranch set, was never on display at the Smithsonian. Following completion of production, the prop was kept by the show's set designer. It was sold several times including to Burghoff himself. It was sold at auction on July 29, 2005 for $11,800, it sold again on March 27, 2015 for $14,307.50 after 19 bids.

Content.

"M*A*S*H" was one of the first network series to feature brief partial nudity (notably Gary Burghoff's buttocks in "The Sniper" and Hawkeye in one of the "Dear Dad" episodes). A different innovation was based on the show's producers' desire not to have a laugh track, contrary to the network's desire to have one. They compromised by omitting laughter in the scenes set in the operating room. The DVD releases of the series allow viewers to select an audio version with no laugh track.  In his blog, writer Ken Levine revealed that on one occasion, when the cast offered too many nitpicking "notes" on a script, his writing partner and he changed the script to a "cold show" – one set during the frigid Korean winter. The cast then had to stand around barrel fires in parkas at the Malibu ranch when the temperatures neared. Levine says, "This happened maybe twice, and we never got a ticky-tack note again."  Jackie Cooper wrote that Alan Alda, whom Cooper directed in several episodes during the first two seasons, concealed a lot of hostility beneath the surface, and the two of them barely spoke to each other by the time Cooper's tenure on the show ended.

Vehicles.

The helicopters used on the series were model H-13 Sioux (military designation and nickname of the Bell 47 civilian model). As in the film, some care seems to have been taken to use the correct model of the long-lived Bell 47 series. In the opening credits and many of the episodes, Korean War-vintage H-13Ds and Es (Bell 47D-1s) were used complete with period-correct external litters. A later (1954–73) 47G occasionally made an appearance. The helicopters are similar in appearance (with the later "G" models having larger two-piece fuel tanks, a slightly revised cabin, and other changes) with differences noticeable only to a serious helicopter fan. In the pilot episode, a later Bell 47J (production began in 1957) was shown flying Henry Blake to Seoul, en route to a meeting with General Hammond in Tokyo. A Sud Aviation Allouette II helicopter was also shown transporting Henry Blake to the 4077th in the episode "Henry, Please Come Home".  The Jeeps used were 1953 military M38 or civil CJ2A Willys Jeeps and also World War II Ford GPWs and Willys MB's. Two episodes featured the M38A1 Jeep, one of which was stolen from a General by Radar and Hawkeye after their Jeep was stolen. Two of the ambulances were WC-54 Dodges and one was a WC-27. A WC-54 ambulance remains at the site and was burned in the Malibu fires on October 9, 1982, while a second WC-27 survives at a South El Monte museum without any markings. The bus used to transport the wounded was a 1954 Ford model. In the last season, an M43 ambulance from the Korean War era also was used in conjunction with the WC-54s and WC-27.

Laugh track.

Series creators Larry Gelbart and Gene Reynolds wanted "M*A*S*H" broadcast without a laugh track. Though CBS initially rejected the idea, a compromise was reached that allowed for omitting the laughter during operating room scenes if desired. "We told the network that under no circumstances would we ever can laughter during an OR scene when the doctors were working," said Gelbart in 1998. "It's hard to imagine that 300 people were in there laughing at somebody's guts being sewn up."  Seasons 1–5 utilized a more invasive laugh track; a more subdued audience was employed for Seasons 6–11 when the series shifted from sitcom to comedy-drama with the departure of Gelbart and Reynolds. Several episodes ("O.R.",d "The Bus", "Quo Vadis, Captain Chandler?", "The Interview", "Point of View", and "Dreams" among them) omitted the laugh track altogether; as did almost all of Season 11, including the 135-minute series finale, "Goodbye, Farewell and Amen". The laugh track is also omitted from some international and syndicated airings of the show; on one occasion during an airing on BBC2, the laugh track was accidentally left on, and viewers expressed their displeasure, an apology from the network for the "technical difficulty" was later released, as during its original run on BBC2 in the UK, it was shown without the laugh track. UK DVD critics speak poorly of the laugh track, stating "canned laughter is intrusive at the best of times, but with a programme like "M*A*S*H", it's downright unbearable."  On all released DVDs, both in Region 1 (including the US and Canada) and Region 2 (Europe, including the UK), an option is given to watch the show with or without the laugh track.  "They're a lie," said Gelbart in a 1992 interview. "You're telling an engineer when to push a button to produce a laugh from people who don't exist. It's just so dishonest. The biggest shows when we were on the air were "All in the Family" and "The Mary Tyler Moore Show" both of which were taped before a live studio audience where laughter made sense," continued Gelbart. "But our show was a film show – supposedly shot in the middle of Korea. So the question I always asked the network was, 'Who are these laughing people? Where did they come from?'" Gelbart persuaded CBS to test the show in private screenings with and without the laugh track. The results showed no measurable difference in the audience's enjoyment. "So you know what they said?" Gelbart said. "'Since there's no difference, let's leave it alone!' The people who defend laugh tracks have no sense of humor." Gelbart summed up the situation by saying, "I always thought it cheapened the show. The network got their way. They were paying for dinner."

Episodes.

Final episode: "Goodbye, Farewell and Amen".

"Goodbye, Farewell and Amen" was the final episode of "M*A*S*H." Special television sets were placed in PX parking lots, auditoriums and day rooms of the U.S. Army in Korea so that military personnel could watch that episode, in spite of 14 hours' time-zone difference with the East Coast of the US. The episode aired on February 28, 1983, and was 2 hours long. The episode got a Nielsen rating of 60.2 and 77 share and according to a "New York Times" article from 1983, the final episode of "M*A*S*H" had 125 million viewers.  When the "M*A*S*H" finale aired in 1983, more than 83.3 million homes in the United States had televisions, compared to almost 115 million in February 2010.  "Goodbye, Farewell and Amen" broke the record for the highest percentage of homes with television sets to watch a television series. Stories persist that the episode was seen by so many people that the New York City Sanitation/Public Works Department reported the plumbing systems broke down in some parts of the city from so many New Yorkers waiting until the end to use the toilet. Articles copied into Alan Alda's book "The Last Days of M*A*S*H" include interviews with New York City Sanitation workers citing the spike in water use on that night. According to the interviews at 11:03 pm, EST New York City public works noted the highest water usage at one given time in the City's history. They attributed this to the fact that in the three minutes after the finale ended, around 77 percent of the people of New York City flushed their toilets. These stories have all since been identified as part of an urban legend dating back to the days of the" Amos and Andy" radio program in the 1930s.  The finale was referenced in a passage from Stephen Chbosky's coming-of-age novel "The Perks of Being a Wallflower," in which the main character and his family watch the finale together.

International broadcast.

And many more international broadcasts.

Reception.

Ratings and recognition.

The series premiered in the US on September 17, 1972, and ended on February 28, 1983, with the finale, showcased as a television film, titled "Goodbye, Farewell and Amen", becoming the most-watched and highest-rated single television episode in US television history at the time, with a record-breaking 125 million viewers (60.2 rating and 77 share), according to the "New York Times." It had struggled in its first season and was at risk of being cancelled. In season two, "M*A*S*H" was placed in a better time slot by CBS (airing after the popular "All in the Family"); the show then became one of the top 10 programs of the year and stayed in the top 20 programs for the rest of its run. It is still broadcast in syndication on various television stations. The series, which depicted events occurring during a three-year war, spanned 256 episodes and lasted 11 seasons. The Korean War lasted 1,128 days, meaning each episode of the series would have averaged almost four and a half days of real time. Many of the stories in the early seasons are based on tales told by real MASH surgeons who were interviewed by the production team. Like the movie, the series was as much an allegory about the Vietnam War (still in progress when the show began) as it was about the Korean War.  The episodes "Abyssinia, Henry" and "The Interview" were ranked number 20 and number 80, respectively, on TV Guide's 100 Greatest Episodes of All Time in 1997. In 2002, "M*A*S*H" was ranked number 25 on TV Guide's 50 Greatest TV Shows of All Time. In 2013, the Writers Guild of America ranked it as the fifth-best written TV series ever and "TV Guide" ranked it as the eighth-greatest show of all time. In 2016, "Rolling Stone" ranked it as the 16th-greatest TV show.

Awards.

"M*A*S*H" was nominated for over 100 Emmy Awards during its 11-year run, winning 14:  The show won the Golden Globe Award for Best Television Series (Musical or Comedy) in 1981. Alan Alda won the Golden Globe for Best Actor in a Television Series (Musical or Comedy) six times: in 1975, 1976, 1980, 1981, 1982, and 1983. McLean Stevenson won the award for Best Supporting Actor in a Television Series in 1974.  The series earned the Directors Guild of America Award for Outstanding Directorial Achievement in a Comedy Series seven times: 1973 (Gene Reynolds), 1974 (Reynolds), 1975 (Hy Averback), 1976 (Averback), 1977 (Alan Alda), 1982 (Alda), 1983 (Alda).  The show was honored with a Peabody Award in 1975 "for the depth of its humor and the manner in which comedy is used to lift the spirit and, as well, to offer a profound statement on the nature of war." "M*A*S*H" was cited as "an example of television of high purpose that reveals in universal terms a time and place with such affecting clarity."  Writers for the show received several Humanitas Prize nominations, with Larry Gelbart winning in 1976, Alan Alda winning in 1980, and the team of David Pollock and Elias Davis winning twice in 1982 and 1983.  The series received 28 Writers Guild of America Award nominations – 26 for Episodic Comedy and two for Episodic Drama. Seven episodes won for Episodic Comedy in 1973, 1975, 1976, 1977, 1979, 1980, and 1981.

Home media.

20th Century Fox Home Entertainment has released all 11 seasons of "M*A*S*H" on DVD in Region 1 and Region 2.  In January 2015, it was announced that the first five seasons of "M*A*S*H" would be available on Netflix's instant streaming service beginning February 1, 2015. This marked the first time the series was made available on an internet platform. As of July 1, 2015, all 11 seasons were available; syndicated versions of hour-long episodes were utilized for streaming, splitting these shows into two parts. In contrast to the DVD sets, the Netflix streams did not have an option for disabling the laugh track on the soundtrack. On April 1, 2016, Netflix' contract to stream the series expired and "M*A*S*H" was removed from the platform.  In July 2017, it was announced that Hulu had acquired online streaming rights for the entire run of "M*A*S*H," along with several other 20th Century Fox-owned TV programs. All 256 episodes were added to Hulu beginning June 29, 2018. All episodes were scanned in 1080 HD from the original 35mm negatives and are presented in 16:9 widescreen.

Spin-offs and specials.

The two-season spin-off "AfterMASH" (1983–1985) inherited the parent show's Monday night time slot and featured several of its characters reunited in a Midwestern hospital after the war. The more successful "Trapper John, M.D." (1979–1986) took place nearly three decades after the events of "M*A*S*H" and depicted Trapper John McIntyre as chief of surgery at a San Francisco hospital; its producers argued successfully in court that it was based on the earlier movie rather than the TV series. In an unpurchased television pilot, "W*A*L*T*E*R" (1984), Walter "Radar" O'Reilly joins the St. Louis police force after his farm fails following his return to the U.S.  "Making M*A*S*H," a documentary special narrated by Mary Tyler Moore that takes viewers behind the production of the season 8 episodes "Old Soldiers" and "Lend a Hand", was produced for PBS in 1981. The special was later included in the syndicated rerun package, with new narration by producer Michael Hirsch.  Two retrospective specials were produced to commemorate the show's 20th and 30th anniversaries:  The two specials are included as bonuses on the Collector's Edition DVD of "Goodbye, Farewell, and Amen". Also included is "M*A*S*H: Television's Serious Sitcom," a 2002 episode of A&E channel's "Biography" program that detailed the show's history.  In the late 1980s, the cast had a partial reunion in a series of commercials for IBM personal computers. All of the front-billed regulars (with the exceptions of Farrell, Stiers, and Stevenson) appeared in the spots over time.

References.

Informational notes Citations Further reading

M*A*S*H (an acronym for Mobile Army Surgical Hospital) is an American war comedy-drama television series that aired on CBS from 1972 to 1983. It was developed by Larry Gelbart as the first original spin-off series adapted from the 1970 feature film "M*A*S*H", which, in turn, was based on Richard Hooker's 1968 novel "". The series, which was produced with 20th Century Fox Television (currently part of Disney Television Studios) for CBS, follows a team of doctors and support staff stationed at the "4077th Mobile Army Surgical Hospital" in Uijeongbu, South Korea, during the Korean War (1950–53). The show's title sequence features an instrumental-only version of "Suicide Is Painless," the original film's theme song. The show was created after an attempt to film the original book's sequel, "M*A*S*H Goes to Maine", failed. The television series is the best-known of the "M*A*S*H" works, and one of the highest-rated shows in U.S. television history.

《风流军医俏护士》(英语:"M*A*S*H")是一套美国连续电视喜剧,由二十世纪霍士制作,1972年在CBS台首播。此剧改编自1970年的同名美国电影(而该片则根据1968年的同名小说改编),是一套混合了黑色幽默的军事医务剧,内容描述朝鲜战争期间,美军当中一班战地医生的经历。


Signs and symptoms.

The main sites of copper accumulation are the liver and the brain, and consequently liver disease and neuropsychiatric symptoms are the main features that lead to diagnosis. People with liver problems tend to come to medical attention earlier, generally as children or teenagers, than those with neurological and psychiatric symptoms, who tend to be in their twenties or older. Some are identified only because relatives have been diagnosed with Wilson's disease; many of these, when tested, turn out to have been experiencing symptoms of the condition but have not received a diagnosis.

Liver disease.

Liver disease may present itself as tiredness, increased bleeding tendency or confusion (due to hepatic encephalopathy) and portal hypertension. The latter, a condition in which the pressure in the portal vein is markedly increased, leads to esophageal varices, blood vessels in the esophagus that may bleed in a life-threatening fashion, as well as enlargement of the spleen (splenomegaly) and accumulation of fluid in the abdominal cavity (ascites). On examination, signs of chronic liver disease such as spider angiomata (small distended blood vessels, usually on the chest) may be observed. Chronic active hepatitis has caused cirrhosis of the liver in most by the time they develop symptoms. While most people with cirrhosis have an increased risk of hepatocellular carcinoma (liver cancer), this risk is relatively very low in Wilson's disease.  About 5% of all people are diagnosed only when they develop fulminant acute liver failure, often in the context of a hemolytic anemia (anemia due to the destruction of red blood cells). This leads to abnormalities in protein production (identified by deranged coagulation) and metabolism by the liver. The deranged protein metabolism leads to the accumulation of waste products such as ammonia in the bloodstream. When these irritate the brain, the person develops hepatic encephalopathy (confusion, coma, seizures and finally life-threatening swelling of the brain).

Neuropsychiatric symptoms.

About half the people with Wilson's disease have neurological or psychiatric symptoms. Most initially have mild cognitive deterioration and clumsiness, as well as changes in behavior. Specific neurological symptoms usually then follow, often in the form of parkinsonism (cogwheel rigidity, bradykinesia or slowed movements and a lack of balance are the most common parkinsonian features) with or without a typical hand tremor, masked facial expressions, slurred speech, ataxia (lack of coordination) or dystonia (twisting and repetitive movements of part of the body). Seizures and migraine appear to be more common in Wilson's disease. A characteristic tremor described as "wing-beating tremor" is encountered in many people with Wilson's; this is absent at rest but can be provoked by abducting the arms and flexing the elbows toward the midline.  Cognition can also be affected in Wilson's disease. This comes in two, not mutually exclusive, categories: frontal lobe disorder (may present as impulsivity, impaired judgement, promiscuity, apathy and executive dysfunction with poor planning and decision making) and subcortical dementia (may present as slow thinking, memory loss and executive dysfunction, without signs of aphasia, apraxia or agnosia). It is suggested that these cognitive involvements are related and closely linked to psychiatric manifestations of the disease.  Psychiatric problems due to Wilson's disease may include behavioral changes, depression, anxiety disorders, and psychosis. Psychiatric symptoms are commonly seen in conjunction with neurological symptoms and are rarely manifested on their own. These symptoms are often poorly defined and can sometimes be attributed to other causes. Because of this, diagnosis of Wilson's disease is rarely made when only psychiatric symptoms are present.

Other organ systems.

Medical conditions have been linked with copper accumulation in Wilson's disease:

Genetics.

The Wilson's disease gene ("ATP7B") is on chromosome 13 (13q14.3) and is expressed primarily in the liver, kidney, and placenta. The gene codes for a P-type (cation transport enzyme) ATPase that transports copper into bile and incorporates it into ceruloplasmin. Mutations can be detected in 90% of cases. Most (60%) are homozygous for "ATP7B" mutations (two abnormal copies), and 30% have only one abnormal copy. Ten percent have no detectable mutation.  Although 300 mutations of "ATP7B" have been described, in most populations the cases of Wilson's disease are due to a small number of mutations specific for that population. For instance, in Western populations the H1069Q mutation (replacement of a histidine by a glutamine at position 1069 in the protein) is present in 37–63% of cases, while in China this mutation is very uncommon and R778L (arginine to leucine at 778) is found more often. Relatively little is known about the relative impact of various mutations, although the H1069Q mutation seems to predict later onset and predominantly neurological problems, according to some studies.  A normal variation in the "PRNP" gene can modify the course of the disease by delaying the age of onset and affecting the type of symptoms that develop. This gene produces prion protein, which is active in the brain and other tissues and also appears to be involved in transporting copper. A role for the "ApoE" gene was initially suspected but could not be confirmed.  The condition is inherited in an autosomal recessive pattern. In order to inherit it, both of the parents of an individual must carry an affected gene. Most have no family history of the condition. People with only one abnormal gene are called carriers (heterozygotes) and may have mild, but medically insignificant, abnormalities of copper metabolism.  Wilson's disease is the most common from a group of hereditary diseases that cause copper overload in the liver. All can cause cirrhosis at a young age. The other members of the group are Indian childhood cirrhosis (ICC), endemic Tyrolean infantile cirrhosis and idiopathic copper toxicosis. These are not related to "ATP7B" mutations: for example, ICC has been linked to mutations in the "KRT8" and the "KRT18" gene.

Pathophysiology.

Copper is needed by the body for a number of functions, predominantly as a cofactor for a number of enzymes such as ceruloplasmin, cytochrome c oxidase, dopamine β-hydroxylase, superoxide dismutase and tyrosinase.  Copper enters the body through the digestive tract. A transporter protein on the cells of the small bowel, copper membrane transporter 1 (Ctr1; SLC31A1), carries copper inside the cells, where some is bound to metallothionein and part is carried by ATOX1 to an organelle known as the trans-Golgi network. Here, in response to rising concentrations of copper, an enzyme called ATP7A (Menkes' protein) releases copper into the portal vein to the liver. Liver cells also carry the CMT1 protein, and metallothionein and ATOX1 bind it inside the cell, but here it is ATP7B that links copper to ceruloplasmin and releases it into the bloodstream, as well as removing excess copper by secreting it into bile. Both functions of ATP7B are impaired in Wilson's disease. Copper accumulates in the liver tissue; ceruloplasmin is still secreted, but in a form that lacks copper (termed apoceruloplasmin) and is rapidly degraded in the bloodstream.  When the amount of copper in the liver overwhelms the proteins that normally bind it, it causes oxidative damage through a process known as Fenton chemistry; this damage eventually leads to chronic active hepatitis, fibrosis (deposition of connective tissue) and cirrhosis. The liver also releases copper into the bloodstream that is not bound to ceruloplasmin. This free copper precipitates throughout the body but particularly in the kidneys, eyes and brain. In the brain, most copper is deposited in the basal ganglia, particularly in the putamen and globus pallidus (together called the "lenticular nucleus"); these areas normally participate in the coordination of movement as well as playing a significant role in neurocognitive processes such as the processing of stimuli and mood regulation. Damage to these areas, again by Fenton chemistry, produces the neuropsychiatric symptoms seen in Wilson's disease.  It is not clear why Wilson's disease causes hemolysis, but various lines of evidence suggest that a high level of free (non-ceruloplasmin bound) copper has a direct effect on either oxidation of hemoglobin, inhibition of energy-supplying enzymes in the red blood cell, or direct damage to the cell membrane.

Diagnosis.

Wilson's disease may be suspected on the basis of any of the symptoms mentioned above, or when a close relative has been found to have Wilson's. Most have slightly abnormal liver function tests such as a raised aspartate transaminase, alanine transaminase and bilirubin level. If the liver damage is significant, albumin may be decreased due to an inability of damaged liver cells to produce this protein; likewise, the prothrombin time (a test of coagulation) may be prolonged as the liver is unable to produce proteins known as clotting factors. Alkaline phosphatase levels are relatively low in those with Wilson's-related acute liver failure. If there are neurological symptoms, magnetic resonance imaging (MRI) of the brain is usually performed; this shows hyperintensities in the part of the brain called the basal ganglia in the T2 setting. MRI may also demonstrate the characteristic "face of the giant panda" pattern.  There is no totally reliable test for Wilson's disease, but levels of ceruloplasmin and copper in the blood, as well of the amount of copper excreted in urine during a 24-hour period, are together used to form an impression of the amount of copper in the body. The gold standard—or most ideal test—is a liver biopsy.

Ceruloplasmin.

Levels of ceruloplasmin are abnormally low (<0.2 g/L) in 80–95% of cases. It can, however, be present at normal levels in people with ongoing inflammation as it is an acute phase protein. Low ceruloplasmin is also found in Menkes disease and aceruloplasminemia, which are related to, but much rarer than Wilson's disease.  The combination of neurological symptoms, Kayser–Fleischer rings and a low ceruloplasmin level is considered sufficient for the diagnosis of Wilson's disease. In many cases, however, further tests are needed.

Serum and urine copper.

Serum copper is low, which may seem paradoxical given that Wilson's disease is a disease of copper excess. However, 95% of plasma copper is carried by ceruloplasmin which is often low in Wilson's disease. Urine copper is elevated in Wilson's disease and is collected for 24 hours in a bottle with a copper-free liner. Levels above 100 μg/24h (1.6 μmol/24h) confirm Wilson's disease, and levels above 40 μg/24h (0.6 μmol/24h) are strongly indicative. High urine copper levels are not unique to Wilson's disease; they are sometimes observed in autoimmune hepatitis and in cholestasis (any disease obstructing the flow of bile from the liver to the small bowel).  In children, the penicillamine test may be used. A 500 mg oral dose of penicillamine is administered, and urine collected for 24 hours. If this contains more than 1600 μg (25 μmol), it is a reliable indicator of Wilson's disease. This test has not been validated in adults.

Liver biopsy.

Once other investigations have indicated Wilson's disease, the ideal test is the removal of a small amount of liver tissue through a liver biopsy. This is assessed microscopically for the degree of steatosis and cirrhosis, and histochemistry and quantification of copper are used to measure the severity of the copper accumulation. A level of 250 μg of copper per gram of dried liver tissue confirms Wilson's disease. Occasionally, lower levels of copper are found; in that case, the combination of the biopsy findings with all other tests could still lead to a formal diagnosis of Wilson's.  In the earlier stages of the disease, the biopsy typically shows steatosis (deposition of fatty material), increased glycogen in the nucleus, and areas of necrosis (cell death). In more advanced disease, the changes observed are quite similar to those seen in autoimmune hepatitis, such as infiltration by inflammatory cells, piecemeal necrosis and fibrosis (scar tissue). In advanced disease, finally, cirrhosis is the main finding. In acute liver failure, degeneration of the liver cells and collapse of the liver tissue architecture is seen, typically on a background of cirrhotic changes. Histochemical methods for detecting copper are inconsistent and unreliable, and taken alone are regarded as insufficient to establish a diagnosis.

Genetic testing.

Mutation analysis of the "ATP7B" gene, as well as other genes linked to copper accumulation in the liver, may be performed. Once a mutation is confirmed, it is possible to screen family members for the disease as part of clinical genetics family counseling. Regional distributions of genes associated with Wilson's disease are important to follow, as this can help clinicians design appropriate screening strategies. Since mutations of the WD gene vary between populations, research and genetic testing done in countries like the USA or United Kingdom can pose problems as they tend to have more mixed populations.

Treatment.

Diet.

In general, a diet low in copper-containing foods is recommended with the avoidance of mushrooms, nuts, chocolate, dried fruit, liver, sesame seeds and sesame oil, and shellfish.

Medication.

Medical treatments are available for Wilson's disease. Some increase the removal of copper from the body, while others prevent the absorption of copper from the diet.  Generally, penicillamine is the first treatment used. This binds copper (chelation) and leads to excretion of copper in the urine. Hence, monitoring of the amount of copper in the urine can be done to ensure a sufficiently high dose is taken. Penicillamine is not without problems: about 20% experience a side effect or complication of penicillamine treatment, such as drug-induced lupus (causing joint pains and a skin rash) or myasthenia (a nerve condition leading to muscle weakness). In those who presented with neurological symptoms, almost half experience a paradoxical worsening in their symptoms. While this phenomenon is observed in other treatments for Wilson's, it is usually taken as an indication for discontinuing penicillamine and commencing second-line treatment. Those intolerant to penicillamine may instead be commenced on trientine hydrochloride, which also has chelating properties. Some recommend trientine as first-line treatment, but experience with penicillamine is more extensive. A further agent, under clinical investigation by Wilson Therapeutics, with known activity in Wilson's disease is tetrathiomolybdate. This is regarded as experimental, though some studies have shown a beneficial effect.  Once all results have returned to normal, zinc (usually in the form of a zinc acetate prescription called Galzin) may be used instead of chelators to maintain stable copper levels in the body. Zinc stimulates metallothionein, a protein in gut cells that binds copper and prevents their absorption and transport to the liver. Zinc therapy is continued unless symptoms recur or if the urinary excretion of copper increases.  In rare cases where none of the oral treatments are effective, especially in severe neurological disease, dimercaprol (British anti-Lewisite) is occasionally necessary. This treatment is injected intramuscularly (into a muscle) every few weeks and has unpleasant side effects such as pain.  People who are asymptomatic (for instance, those diagnosed through family screening or only as a result of abnormal test results) are generally treated, as the copper accumulation may cause long-term damage in the future. It is unclear whether these people are best treated with penicillamine or zinc acetate.

Physical and occupational therapies.

Physiotherapy and occupational therapy are beneficial for patients with the neurologic form of the disease. The copper chelating treatment may take up to six months to start working, and these therapies can assist in coping with ataxia, dystonia, and tremors, as well as preventing the development of contractures that can result from dystonia.

Transplantation.

Liver transplantation is an effective cure for Wilson's disease but is used only in particular scenarios because of the risks and complications associated with the procedure. It is used mainly in people with fulminant liver failure who fail to respond to medical treatment or in those with advanced chronic liver disease. Liver transplantation is avoided in severe neuropsychiatric illness, in which its benefit has not been demonstrated.

Prognosis.

Left untreated, Wilson's disease tends to become progressively worse and is eventually fatal. With early detection and treatment, most of those affected can live relatively normal lives. Liver and neurologic damage that occurs prior to treatment may improve, but it is often permanent.

History.

The disease bears the name of the British physician Samuel Alexander Kinnier Wilson (1878–1937), a neurologist who described the condition, including the pathological changes in the brain and liver, in 1912. Wilson's work had been predated by, and drew on, reports from German neurologist Carl Westphal (in 1883), who termed it "pseudosclerosis"; by the British neurologist William Gowers (in 1888); by the Finnish neuropathologist Ernst Alexander Homén (in 1889-1892), who noted the hereditary nature of the disease; and by Adolph Strümpell (in 1898), who noted hepatic cirrhosis. Neuropathologist John Nathaniel Cumings made the link with copper accumulation in both the liver and the brain in 1948. The occurrence of hemolysis was noted in 1967.  Cumings, and simultaneously the New Zealand neurologist Derek Denny-Brown, working in the United States, first reported effective treatment with metal chelator British anti-Lewisite in 1951. This treatment had to be injected but was one of the first therapies available in the field of neurology, a field that classically was able to observe and diagnose but had few treatments to offer. The first effective oral chelation agent, penicillamine, was discovered in 1956 by British neurologist John Walshe. In 1982, Walshe also introduced trientine, and was the first to develop tetrathiomolybdate for clinical use. Zinc acetate therapy initially made its appearance in the Netherlands, where physicians Schouwink and Hoogenraad used it in 1961 and in the 1970s, respectively, but it was further developed later by Brewer and colleagues at the University of Michigan.  The genetic basis of Wilson's disease and linkage to "ATP7B" mutations was elucidated in the 1980s and 1990s by several research groups.

Other animals.

Hereditary copper accumulation has been described in Bedlington Terriers, where it generally only affects the liver. It is due to mutations in the "COMMD1" (or "MURR1") gene. Despite this findings, "COMMD1" mutations could not be detected in humans with non-Wilsonian copper accumulation states (such as Indian childhood cirrhosis) to explain their genetic origin.

Wilson's disease is a genetic disorder in which excess copper builds up in the body. Symptoms are typically related to the brain and liver. Liver-related symptoms include vomiting, weakness, fluid build up in the abdomen, swelling of the legs, yellowish skin and itchiness. Brain-related symptoms include tremors, muscle stiffness, trouble speaking, personality changes, anxiety and seeing or hearing things that others do not. Wilson's disease is caused by a mutation in the Wilson disease protein ("ATP7B") gene. This protein transports excess copper into bile, where it is excreted in waste products. The condition is autosomal recessive; for a person to be affected, they must inherit a mutated copy of the gene from both parents. Diagnosis may be difficult and often involves a combination of blood tests, urine tests and a liver biopsy. Genetic testing may be used to screen family members of those affected. Wilson's disease is typically treated with dietary changes and medication. Dietary changes involve eating a low-copper diet and not using copper cookware. Medications used include chelating agents such as trientine and d-penicillamine and zinc supplements. Complications of Wilson's disease can include liver failure, liver cancer and kidney problems. A liver transplant may be helpful in those in whom other treatments are not effective or if liver failure occurs. Wilson's disease occurs in about 1 in 30,000 people. Symptoms usually begin between the ages of 5 and 35 years. It was first described in 1854 by German pathologist Friedrich Theodor von Frerichs and is named after British neurologist Samuel Wilson.

肝豆状核变性系为一种肝豆状(又称 ATP7B)基因内发生的隐性突变。患者必然是从双亲之一遗传了突变复制基因。要确诊此症并不容易,而且常常会需要做许多血液检查,尿液检查及肝脏活体组织切片;或许也需要患者的家人也接受基因检测。 肝豆状核变性的治疗方式以改变饮食和药物为主,改变饮食有低铜饮食及避免使用铜制炊具,使用药物为螯合物,如曲恩汀、D-青霉胺和锌补充剂。并发症有肝衰竭,肝癌和肾小管性酸中毒。若患者患有肝衰竭或其他治疗方式都不见效,或许会采用肝脏移植。 约每30,000人中会出现一位肝豆状核变性患者,通常症状显现于5至35岁之间,患者的男女比例一致。早在1854年,Friedrich Theodor von Frerichs就留有肝豆状核变性的记叙,因山穆·威尔森研究贡献卓越,此症的别名就以他之名广为流传。


Ancient world.

The origin of the military baton is unclear. In western Europe, batons served a similar purpose as the "Roman fasces lictoriae": a symbol of power and authority. A short, heavy, white baton was the symbol of the imperial mandate given to a Roman military legate. He held it high proclaiming "above your head and mine" to represent the emperor.  It is possible that the Spartan cipher rod, "scytale", also had a related military status, pre-dating the Roman baton, but the first detailed reference in Plutarch dates from the Roman period.

Middle ages to early modern period.

Batons were given to top commanders in most European armies from at least the Renaissance, as a revival of classical practice. They were typically presented by the monarch, and latterly were often elaborate pieces of metalwork, though earlier portraits show plain batons of wood, often longer and thinner than later examples. They were also typically carried by monarchs when portrayed in military dress. The French kings, and Napoleon, provided Marshals of France with ornate batons, typically of blue velvet with metal fleurs-de-lys before the French Revolution, then stars or Napoleonic bees.  The Duke of Wellington possessed multiple batons, since he held the rank of field marshal or equivalent in eight European armies each of which presented him with a baton. In addition to his English baton he was presented with two British batons. Nine of the batons (along with some staffs of office) are displayed at his former home, Apsley House (the Russian baton was stolen on 9 December 1965 and has not been recovered).  Tsar Alexander I (1801–1825) presented five batons, one to the Duke of Wellington and four to Russian generals.  Crossed batons may appear as the distinctive uniform rank insignia on (epaulettes or shoulder boards) of field marshals. The Third Reich-era "Generalfeldmarschall's" insignia is an example of this, as is that of the Field Marshal of the United Kingdom. In any event, while doing their routine work modern field marshals often carry simpler batons, keeping more elaborate ones for ceremonial occasions.

Nazi Germany.

In Nazi Germany, "Generalfeldmarschall"s and "Großadmiral"s carried ceremonial batons, specially manufactured by German jewellers. Seven styles of batons were awarded to 25 individuals. Hermann Göring earned two different-style batons for his "Generalfeldmarschall" and "Reichsmarschall" promotions.  All the batons, except Erich Raeder's, were designed in a similar way: a shaft decorated with Iron Crosses and. "Luftwaffe" (air force) shafts showed the "Balkenkreuz" ("beam cross"), whereas "Kriegsmarine" (navy) shafts had fouled anchors. The ends of the batons were decorated with ornate caps.

In heraldry.

The baton appears occasionally in heraldry as insignia for those entitled to do display them. The baton was mostly used, in and behind the escutcheon, by military men and not by ordinary persons even if they were actually in possession of this military symbol. The batons are usually represented as two behind the coat of arms crossed in saltire.

The ceremonial baton is a short, thick stick-like object, typically in wood or metal, that is traditionally the sign of a field marshal or a similar very high-ranking military officer, and carried as a piece of their uniform. The baton is distinguished from the swagger stick in being thicker and effectively without any practical function. A staff of office is rested on the ground; a baton is not. Unlike a royal sceptre that is crowned on one end with an eagle or globe, typically a baton is flat-ended.

元帅杖是元帅阶级的军人所专有,表现其地位与荣誉的道具。元帅杖有分两种,一种是在正式场合所带的正式权杖(Marschallstab),另一种则是较为轻便的临时权杖(Interimstab)。世界上以纳粹德国的元帅杖较有名,而大日本帝国则以元帅刀代替元帅杖。


History.

The growing uses of paper in the 19th century created a demand for an efficient paper fastener.  In 1866, George McGill received U.S. patent 56,587 for a small, bendable brass paper fastener that was a precursor to the modern staple. In 1867, he received U.S. patent 67,665 for a press to insert the fastener into paper. He showed his invention at the 1876 Centennial Exhibition in Philadelphia, Pennsylvania, and continued to work on these and other various paper fasteners throughout the 1880s. In 1868 an English patent for a stapler was awarded to C. H. Gould, and in the U.S, Albert Kletzker of St. Louis, MO also patented a device.  In 1877 Henry R. Heyl filed patent number 195,603 for the first machines to both insert and clinch a staple in one step, and for this reason some consider him the inventor of the modern stapler. In 1876 and 1877 Heyl also filed patents for the Novelty Paper Box Manufacturing Co. of Philadelphia, PA, However, the N. P. B. Manufacturing Co.'s inventions were to be used to staple boxes and books.  The first machine to hold a magazine of many pre-formed staples came out in 1878.  On February 18, 1879, George McGill received patent 212,316 for the McGill Single-Stroke Staple Press, the first commercially successful stapler. This device weighed over two and a half pounds and loaded a single 1/2 inch wide wire staple, which it could drive through several sheets of paper.  The first published use of the word "stapler" to indicate a machine for fastening papers with a thin metal wire was in an advertisement in the American "Munsey's Magazine" in 1901.  In the early 1900s, several devices were developed and patented that punched and folded papers to attach them to each other without a metallic clip. The "Clipless Stand Machine" (made in North Berwick) sold from 1909 into the 1920s. It cut a tongue in the paper that it folded back and tucked in. "Bump's New Model Paper Fastener" used a similar cutting and weaving technology.

The modern stapler.

In 1941 the type of paper stapler that is the most common in use today was developed: the four way paper stapler. With the four way, the operator could either use the stapler to staple papers to wood or cardboard, or used to staple like pliers for bags, or the normal way with the head positioned a small distance above the stapling plate. The stapling plate is known as the anvil. The anvil often has two settings: the first, and by far most common, is the reflexive setting, also known as the "primary" or "permanent" setting. In this position the legs of the staple are folded toward the center of the cross bar. It is used to staple papers which are not expected to need separation. If rotated 180° or slid to its second position, the anvil will be set on the sheer setting, also known as "secondary", "temporary", or "straight". In this position the legs of the staple are folded outwards, away from the cross bar, resulting in the legs and cross bar being in more or less a straight line. Stapling with this setting will result in more-weakly secured papers, but a staple that is much easier to remove. The use of the second setting is almost never seen, however, due to the prevalence of staple removers and the general lack of knowledge about its use. Some simple modern staplers feature a fixed anvil that lacks the sheer position.  Modern staplers continue to evolve and adapt to the changing habits of users. Less-effort, or easy-squeeze/use staplers, for example, make use of different leverage efficiencies to reduce the amount of force the user need apply. As a result, these staplers tend to be used in work environments where repetitive, large stapling jobs are routine.  Some modern desktop staplers make use of Flat Clinch technology. With Flat Clinch staplers, the staple legs first pierce the paper and are then bent over and pressed absolutely flat against the paper – doing away with the two-setting anvil commonly used and making use of a recessed stapling base in which the legs are folded. Accordingly, staples do not have sharper edges exposed and lead to flatter stacking of paper – saving on filing and binder space.

Industry.

In 2012, $80 million worth of staplers were sold in the US. The dominant US manufacturer is Swingline.

Methods.

Permanent fastening binds items by driving the staple through the material and into an "anvil", a small metal plate that bends the ends, usually inward. On most modern staplers, the anvil rotates or slides to change between bending the staple ends inward for permanent stapling or outward for "pinning" (see below). Clinches can be standard, squiggled, flat, or rounded completely adjacent to the paper to facilitate neater document stacking.  Pinning temporarily binds documents or other items. To pin, the anvil slides or rotates so that the staple bends outwards instead of inwards. Some staplers pin by bending one leg of the staple inwards and the other outwards. The staple binds the item with relative security, but is easily removed.  Tacking fastens objects to surfaces, such as bulletin boards or walls. A stapler that can tack has a base that folds back out of the way so staples drive directly into an object rather than fold against the anvil. In this position the staples are driven similar to the way a staple gun works, but with less force driving the staple.  Saddle staplers have an inverted V-shaped saddle for stapling pre-fold sheets to make booklets.  Stapleless staplers, invented in 1910, are a means of stapling that punches out a small flap of paper and weaves it through a notch. A more recent alternative method avoids the resulting hole by crimping the pages together with serrated metal teeth instead.

Surgical staplers.

Surgeons can use surgical staplers in place of sutures to close the skin, or during surgical anastomosis. A surgical stapler doesn't resemble a standard stapler, as it has no anvil. Surgical staples are commonly preshaped into an "M". Pressing the stapler into the skin and applying pressure onto the handle bends the staple through the skin and into the fascia, until the two ends almost meet in the middle to form a rectangle.  Staplers are commonly used intra-operatively during bowel resections in colorectal surgery. Often these staplers have an integral knife which, as the staples deploy, cuts through the bowel and maintains the aseptic field. The staples, made from surgical steel, are typically supplied in disposable sterilized cartridges.

A stapler is a mechanical device that joins pages of paper or similar material by driving a thin metal staple through the sheets and folding the ends. Staplers are widely used in government, business, offices, work places, homes and schools.

订书机(又作钉书机)是一种文书工具,它利用小的金属(即订书针)把多张纸张或其它物件结合在一起,订书针的两只针脚穿过物件,并在物件的背面折曲,造成固定位置的效果。订书机经常被用在办公室或其它地方,用以整理大量松散的纸张文件。


Personal life.

Arakawa was born in Shinagawa, Tokyo, Japan, and grew up in Sendai and its suburbs. She is the only child of Koichi and Sachi Arakawa and was named Shizuka after Shizuka Gozen.  In March 2000, Arakawa enrolled at Waseda University and graduated with a bachelor's degree in social sciences in 2004, while still competing as a skater. She won the 2004 World Figure Skating Championships days after completing her graduation examinations at Waseda University.  She lived and trained for a time at the International Skating Center of Connecticut in Simsbury, Connecticut after the closure of the Konami Sports Ice Rink in Sendai, where she began her career.  Her figure skating idols are Kristi Yamaguchi and Yuka Sato. She listens to music by Christina Aguilera, Beyoncé, Mai Kuraki (who is also a close friend of hers) and EXILE, and likes shopping, driving, swimming, golf and practicing marine sports. Arakawa cites gourmet cooking as one of her hobbies. She collects beanie babies, has a pet shih tzu (named Charo) and hamster (named Juntoki). She also has four dogs, named Choco, Tiramisu, Aroma and Rosa.  Arakawa was married on December 29, 2013, her 32nd birthday. Further details were not made public.  On April 16, 2014, Arakawa announced that she was pregnant and expecting her first child. On November 6, 2014, she gave birth to her first child, a daughter. On May 23rd, 2018, it was announced that she had given birth to her second child, a son.

Career.

Early career.

When Arakawa was 5 years old, she became interested in skating and entered the Chibikko Skate School. She started ballet lessons at 7. While still 7, Arakawa began training with former Olympian Hiroshi Nagakubo, a pair skater who competed in the 1972 Winter Olympics in Sapporo, Japan. She was landing triple salchows at age 8.  In 1994, she began participating in Japanese national skating competitions. She was named the 1994, 1995, 1996 "All Japan Junior Figure" athlete. Arakawa progressed through the Japanese ranks quickly and was the first skater in Japan to win three consecutive junior national titles.

Senior career.

Arakawa was the senior national Japanese champion in both 1998 and 1999. She made her Olympic debut when she represented Japan in the 1998 Winter Olympics in Nagano at age 16. The Emperor and Empress of Japan attended the ladies' free skate event. She placed 13th at the Nagano Olympics. At that time, she was ranked number 2 in Japan. In 2002, Arakawa finished second at Japan's national championships and, as a result, was not named to the Japanese 2002 Winter Olympics team.  During the 2002–2003 skating season, Arakawa won the Asian Winter Games and the Winter Universiade. She earned her second consecutive silver medal at the Four Continents Championships. She took the bronze at the NHK Trophy, and placed fifth at the Cup of Russia. She qualified for the ISU Grand Prix Final, where she finished fourth. She later placed third at the Japanese Nationals, marking her fifth medal from this meet, with two golds and two silvers from previous seasons.  In 2004, she won the World Championships in Dortmund, Germany, after landing seven clean triple jumps. She was the third Japanese woman to win this title after Midori Ito who won in 1989 and Yuka Sato in 1994. Arakawa had planned to retire after the 2004 World Championships, but her victory there convinced her to change her plans.  At the 2005 World Championships, Arakawa finished 9th, a disappointment which she later credited as a motivation to stay in the sport and regain top form. She felt she could not quit on such a down note. In November 2005, Arakawa changed coaches to Nikolai Morozov.

2006 Winter Olympics.

At the 2006 Winter Olympics in Turin, Italy, Arakawa skated in the short program to Fantaisie-Impromptu by Chopin. She went into the long program in third place, behind pre-event favorites Sasha Cohen and Irina Slutskaya. Less than a point separated the top three skaters. In the long program, Cohen was the first of the three leaders to skate, followed by Arakawa and Slutskaya. Cohen fell twice during her long program, leaving the door open to the other leaders.  Arakawa won the free program, skating to Vanessa Mae's Violin Fantasy on Puccini's Turandot by Giacomo Puccini. She performed an Ina Bauer and then did a three jump combination. "Ina Bauer" became a household word in Japan as a result. Although she had planned two triple-triple combinations for the free skate, she did not perform them, doing instead a triple Lutz-double loop and a triple salchow-double toe loop combinations. Arakawa earned a total combined score of 191.34 points, almost eight points ahead of the second-place Cohen (183.36). Like Cohen, Slutskaya made mistakes in her long program, and ended up taking bronze, leaving Arakawa as the gold medal winner, which was also Japan's only medal of the 2006 games. Slutskaya was third at 181.44. At age 24, Arakawa became the oldest women's Olympic skating champion in more than 80 years. Florence "Madge" Cave Syers from the United Kingdom was the oldest when she won the Olympic title at age 27 at the 1908 Summer Olympics, which featured the first Olympic figure skating events.  After winning her Olympic title, Japanese Prime Minister Junichiro Koizumi called Arakawa in Turin, Italy to congratulate her. Koizumi said, "I cheered for you with excitement while I watched television. All the Japanese people are rejoicing. I give a perfect score to every bit of your performance."

Professional career.

Arakawa retired after her Olympic victory. She continues to skate in exhibition programs and is a regular skating commentator for Japanese TV. She competed in the 2006 Ice Wars on the World team. She also produces her own show, "Friends on Ice". Arakawa also does choreography.  In 2006, Arakawa appeared in a Japanese TV drama, "Shichinin no onna bengoshi" (7 female lawyers), presented by Asahi TV. She played the role of a cool public prosecutor, Yayoi Shimasaki, in the 8th episode.  She competed in an ABC skating series "Thin Ice," aired on March 19, 2010, paired with 2006 Olympic men's silver medallist Stéphane Lambiel. They came first in the viewer's votes, and ended the series in third place, winning a total of $45,000. They skated to the songs "Get Me Bodied" by Beyoncé and "Magic" by Robin Thicke.  On April 18, 2018, it was announced Arakawa was elected to the World Figure Skating Hall of Fame.

Signature moves.

Arakawa is known for her jumping ability, particularly her difficult triple-triple combinations, like the triple salchow-triple toe and the triple lutz-triple toe, sometimes combined with a double loop. She has executed triple-triple-triple combinations in practice, the most of which have been the triple salchow-triple toe-triple loop combination. She has also executed the triple lutz-triple loop combination in practice.  Arakawa is known for the quietness of her blades. She is also a strong spinner. She has an excellent donut spin, a difficult variation of the Camel spin, that requires great flexibility. In 2004, she added a Biellmann spin to her repertoire. Arakawa's signature spiral is a Y-spiral where she releases her free leg and completes the spiral with her leg still close to her head, without the hand assist.  Her trademark move is the Ina Bauer with a full backbend. Due to Arakawa's use of this move during her free skate at the 2006 Olympics, the term "Ina Bauer" became very popular in Japan, and Arakawa's performance of it became iconic. The Ina Bauer move is often referred to in Japan by Arakawa's name.

Awards and honors.

Japan Medals of Honor Japanese Olympic Committee Municipality  World Figure Skating Hall of Fame

Competitive highlights.

"GP: Grand Prix / Champions Series"

Arakawa retired from competitive skating following her Olympic win and began skating professionally in ice shows and exhibitions. She also works as a skating sportscaster for Japanese television.

荒川静香(,英语:Shizuka Arakawa,1981年-12月29日)是日本花样滑冰运动员。她在2004年世界花样滑冰锦标赛获得冠军,成为第四位亚洲女子单人滑世界冠军,并于2006年冬季奥林匹克运动会上成为亚洲第一位花样滑冰女子单人滑冠军。


Structure.

The gastrocnemius is located with the soleus in the posterior (back) compartment of the leg. The lateral head originates from the lateral condyle of the femur, while the medial head originates from the medial condyle of the femur. Its other end forms a common tendon with the soleus muscle; this tendon is known as the calcaneal tendon or Achilles tendon and inserts onto the posterior surface of the calcaneus, or heel bone. It is considered a superficial muscle as it is located directly under skin, and its shape may often be visualized through the skin.  Deep to the gastrocnemius (farther from the skin) is the soleus muscle. Some anatomists consider both to be a single muscle—the triceps surae or "three-headed [muscle] of the calf"—since they share a common insertion via the Achilles tendon. The plantaris muscle and a portion of its tendon run between the two muscles, which is involved in "locking" the knee from the standing position. Since the anterior compartment of the leg is lateral to the tibia, the bulge of muscle medial to the tibia on the anterior side is actually the posterior compartment. The soleus is superficial to the mid-shaft of the tibia.

Variation.

10% to 30% of individuals have a sesamoid bone called the "fabella" in the lateral (outer) head of the gastrocnemius muscle.

Function.

Along with the soleus muscle, the gastrocnemius forms half of the calf muscle. Its function is plantar flexing the foot at the ankle joint and flexing the leg at the knee joint.  The gastrocnemius is primarily involved in running, jumping and other "fast" movements of leg, and to a lesser degree in walking and standing. This specialization is connected to the predominance of white muscle fibers (type II fast twitch) present in the gastrocnemius, as opposed to the soleus, which has more red muscle fibers (type I slow twitch) and is the primary active muscle when standing still, as determined by EMG studies.

Motor pathway.

The plan to use the gastrocnemius in running, jumping, knee and plantar flexing is created in the precentral gyrus in the cerebrum of the brain. Once a plan is produced, the signal is sent to and down an upper motor neuron. The signal is passed through the internal capsule and decussates, or crosses, in the medulla oblongata, specifically in the lateral corticospinal tract. The signal continues down through the anterior horn of the spinal cord where the upper motor neuron synapses with the lower motor neuron. Signal propagation continues down the anterior rami (Lumbar 4-5 and Sacral 1-5) of the sacral plexus. The sciatic nerve branches off of the sacral plexus in which the tibial and common fibular nerves are wrapped in one sheath. The tibial nerve eventually separates from the sciatic nerve and innervates the gastrocnemius muscle. Thus, completing the plan the brain had originally started with, so that the actions of running, standing, and jumping could be executed.

Clinical significance.

The gastrocnemius muscle is prone to spasms, which are painful, involuntary contractions of the muscle that may last several minutes.  A severe ankle dorsiflexion force may result in an injury of the muscle, commonly referred to as a "torn" or "strained" calf muscle, which is acutely painful and disabling.  The gastrocnemius muscle may also become inflamed due to overuse. Anti-inflammatory medications and physical therapy (heat, massage, and stretching) may be useful.  Anatomical abnormalities involving the medial head of gastrocnemius muscle result in popliteal artery entrapment syndrome.

History.

In a 1967 EMG study, Herman and Bragin concluded that its most important role was plantar flexing in large contractions and in rapid development of tension.

The gastrocnemius muscle (plural "gastrocnemii") is a superficial two-headed muscle that is in the back part of the lower leg of humans. It runs from its two heads just above the knee to the heel, a three joint muscle (knee, ankle and subtalar joints). The muscle is named via Latin, from Greek "γαστήρ" ("gaster") 'belly' or'stomach' and "κνήμη" ("knḗmē") 'leg', meaning'stomach of leg' (referring to the bulging shape of the calf).

腓肠肌是腿部最大的屈肌,其拉丁文「」意谓腿肚子。腓肠肌沿着小腿背后,从股骨的远端向下延伸到跟骨。当其收缩时,可使足向下弯曲,并辅助膝盖弯曲。腓肠肌是透过跟腱与足跟相连接。


Overview.

Throughout history, only children were relatively uncommon. From around the middle of the 20th century, birth rates and average family sizes fell sharply, for a number of reasons including increasing costs of raising children and more women having their first child later in life. The proportion of families in the United States with only children increased during the Great Depression but fell during the Post–World War II baby boom. After the Korean War ended in 1953, the South Korean government suggested citizens each have one or two children to boost economic prosperity, which resulted in significantly reduced birth rates and a larger number of only children to the country.  From 1979-2015, the one-child policy in the People's Republic of China restricted most parents to having only one child, although it was subject to local relaxations and individual circumstances (for instance when twins were conceived).  Families may have an only child for a variety of reasons, including: personal preference, family planning, financial and emotional or physical health issues, desire to travel, stress in the family, educational advantages, late marriage, stability, focus, time constraints, fears over pregnancy, advanced age, illegitimate birth, infertility, divorce, and death of a sibling or parent. The premature death of one parent also contributed to a small percentage of marriages producing just one child until around the mid 20th century, not to mention the then rare occurrence of divorce.  Only children are sometimes said to be more likely to develop precocious interests (from spending more time with adults) and to feel lonely. Sometimes they compensate for the aloneness by developing a stronger relationship with themselves or developing an active fantasy life that includes imaginary friends. Children whose only siblings are much older than them sometimes report feeling like an only child. Advantages cited of having an only child are the decreased financial burden, the absence of any sibling rivalry, and that it becomes possible to take the child to an event suitable for their age without having to bring along an uninterested sibling.

Stereotypes.

In Western countries, only children can be the subject of a stereotype that equates them with "spoiled brats". G. Stanley Hall was one of the first commentators to give only children a bad reputation when he referred to their situation as "a disease in itself". Even today, only children are commonly stereotyped as "spoiled, selfish, and bratty". While many only children receive a lot of attention and resources for their development, it is not clear that as a class they are overindulged or differ significantly from children with siblings. Susan Newman, a social psychologist at Rutgers University and the author of "Parenting an Only Child", says that this is a myth. "People articulate that only children are spoiled, they're aggressive, they're bossy, they're lonely, they're maladjusted", she said. "There have been hundreds and hundreds of research studies that show that only children are no different from their peers." However, differences have been found. Research involving teacher ratings of U.S. children's social and interpersonal skills has scored only children lower in self-control and interpersonal skills. While a later study failed to find evidence this continued through middle and high school, a further study showed that deficits persisted until at least the fifth grade.  In China, perceived behavioral problems in only children has been called the Little Emperor Syndrome and the lack of siblings has been blamed for a number of social ills such as materialism and crime. However, recent studies do not support these claims, and show no significant differences in personality between only children and children in larger families. The one child policy has also been speculated to be the underlying cause of forced abortions, female infanticide, underreporting of female births, and has been suggested as a possible cause behind China's increasing number of crimes and gender imbalance. Regardless, a 2008 survey given by the Pew Research Center reports that 76% of the Chinese population supports the policy.  The popular media often posit that it is more difficult for only children to cooperate in a conventional family environment, as they have no competitors for the attention of their parents and other relatives. It is suggested that confusion arises about the norms of ages and roles and that a similar effect exists in understanding during relationships with other peers and youth, all throughout life. Furthermore, it is suggested that many feel that their parents place extra pressure and expectations on the only child, and that often, only children are perfectionists. Only children are noted to have a tendency to mature faster.

Scientific research.

A 1987 quantitative review of 141 studies on 16 different personality traits failed to support the opinion, held by theorists including Alfred Adler, that only children are more likely to be maladjusted due to pampering. The study found no evidence of any greater prevalence of maladjustment in only children. The only statistically significant difference discovered was that only children possessed a higher achievement motivation, which Denise Polit and Toni Falbo attributed to their greater share of parental resources, expectations, and scrutiny exposing them to a greater degree of reward, and greater likelihood of punishment for falling short. A second analysis by the authors revealed that only children, children with only one sibling, and first-borns in general, score higher on tests of verbal ability than later-borns and children with multiple siblings.  According to the Resource Dilution Model, parental resources (e.g. time to read to the child) are important in development. Because these resources are finite, children with many siblings are thought to receive fewer resources. However, the Confluence Model suggests there is an opposing effect from the benefits to the non-youngest children of tutoring younger siblings, though being tutored does not make up the reduced share of parental resources. This provides one explanation for the poorer performance on tests of ability of only children compared to first-borns, commonly seen in the literature, though explanations such as the increased and earlier likelihood of experiencing parental separation or loss for last-born and only children have also been suggested, as this may be the cause of their very status.  In his book "Maybe One", the environmental campaigner Bill McKibben argues in favor of a voluntary one child policy on the grounds of climate change and overpopulation. He reassures the reader with a narrative constructed from interviews with researchers and writers on only children, combined with snippets from the research literature, that this would not be harmful to child development. He argues that most cultural stereotypes are false, that there are not many differences between only children and other children, and where there are differences, they are favorable to the only child.  Most research on only children has been quantitative and focused on the behaviour of only-children and on how others, for example teachers, assess that behaviour. Bernice Sorensen, in contrast, used qualitative methods in order to elicit meaning and to discover what only-children themselves understand, feel or sense about their lives that are lived without siblings. Her research showed that during their life span only children often become more aware of their only child status and are very much affected by society's stereotype of the only-child whether or not the stereotype is true or false. She argues in her book, "Only Child Experience and Adulthood", that growing up in a predominantly sibling society affects only children and that their lack of sibling relationships can have an important effect on both the way they see themselves and others and how they interact with the world.  The latest research by Cameron et al. (2011) controls for endogeneity associated with being only children. Parents that choose to have only one child could differ systematically in their characteristics from parents who choose to have more than one child. The paper concludes that "those who grew up as only children as a consequence of the (one-child) policy (in China) are found to be less trusting, less trustworthy, less likely to take risks, and less competitive than if they had had siblings. They are also less optimistic, less conscientious, and more prone to neuroticism". Furthermore, according to Professor Cameron, it was found that "greater exposure to other children in childhood – for example, frequent interactions with cousins and/or attending childcare – was not a substitute for having siblings."  In his book "Born to Rebel", Frank Sulloway provides evidence that birth order influences the development of the "big five personality traits" (also known as the Five Factor Model). Sulloway suggests that firstborns and only children are more conscientious, more socially dominant, less agreeable, and less open to new ideas compared to laterborns. However, his conclusions have been challenged by other researchers, who argue that birth order effects are weak and inconsistent. In one of the largest studies conducted on the effect of birth order on the Big Five, data from a national sample of 9,664 subjects found no association between birth order and scores on the NEO PI-R personality test.

An only child is a person with no siblings, biological nor adopted.

独生子女,指没有兄弟姐妹的人,独生子又称作独苗或独丁。世界多个先进国家和地区均出现少子化现象,源于不少夫妇只愿意生育一至两个子女,令独生子女越来越多;另外两个子女的情况,假如其中一个早逝(通常指未成年),另一个也会成为独生子女,当然以后再有弟妹的情况就不算。中国大陆20世纪70年代末以来实行计划生育政策,产生了大批的独生子女。


Lineage.

The remains of dogs that have been found in Finland and dated from 8,000 years ago are similar in size and shape to Spitz-type dogs.  Nearly all dog breeds’ genetic closeness to the gray wolf is due to admixture. However, several Arctic dog breeds show a genetic closeness with the now-extinct Taymyr wolf of North Asia due to admixture. These breeds are associated with high latitudes - the Siberian husky and Greenland dog that are also associated with arctic human populations, and to a lesser extent the Shar Pei and the Karelo-Finnish Laika. An admixture graph of the Greenland dog indicates a best-fit of 3.5% shared material, however an ancestry proportion ranging between 1.4% and 27.3% is consistent with the data. This indicates admixture between the Taymyr wolf population and the ancestral dog population of these 4 high-latitude breeds. This introgression could have provided early dogs living in high latitudes with phenotypic variation beneficial for adaption to a new and challenging environment. It also indicates the ancestry of present-day dog breeds descends from more than one region.

History.

The Finnish Spitz developed from selectively bred Spitz-type dogs that inhabited central Russia several thousand years ago. Isolated Finno-Ugrian tribes in the far northern regions bred dogs according to their specific needs. These small clans of woodsmen relied on their dogs to help them obtain food, and the excellent hunting ability of the Finnish Spitz made it a favorite choice.  By 1880, as advanced means of transportation brought diverse peoples and their dogs together, Finnish Spitzes mated with other breeds of dogs, and were becoming extinct as a distinct breed. At about that time, a Finnish sportsman from Helsinki named Hugo Roos observed the pure native Finnish Spitz while hunting in the northern forests. He realized the many virtues of the pure Finnish Spitz breed and decided to select dogs that were untainted examples of the genuine Finnish Spitz in order to try to revive the breed. Thirty years of careful breeding resulted in the modern Finnish Spitz; the dogs are descendants of his original foundation stock. Love Finnish Kennel Club has revised the breed standard six times, and the latest version was confirmed in 1996. In 1979, when the club celebrated its 90th anniversary, the Finnish Spitz was declared Finland's national dog breed. The club is also working for including the hunting experience with the Finnish Spitz on the UNESCO Intangible Cultural Heritage List.

Appearance.

The proper conformation is a square build, meaning that the length of the body is the same or slightly shorter than the height of the withers to the ground. The length of the body is measured from the point of the shoulder or forechest in front of the withers to the rump. Females are usually a little longer in the back than males. Both sexes should appear slightly longer in the leg than the back.  Dew claws can appear on front and/or back feet. If back claws appear, they should be removed. The front dewclaws can be removed, if desired.

Coat.

The Finnish Spitz has a typical double coat, which consists of a soft, dense undercoat and long, harsh guard hairs that can measure 2.5 to 5 cm (one to two inches) long. The outer coat should not exceed at the ruff. The coat should be stiffer, denser, and longer on the neck, back, back of thighs, and plume of the tail, shorter on the head and legs. Male dogs should sport a slightly longer and coarser coat than female ones, who have a slightly more refined coat.  The pluma of the tail is important to the overall look of the dog but should not be too long. Feathered long tail hairs without sustenance can give the dog an unkempt look. Additionally, the tailset is important and the Finnish Spitz should be able to move its tail from one side to the other. Most Finnish Spitz have a preferred side and this is not incorrect.  Proper care of the coat is most important. The Finnish Spitz blows coat or loses its undercoat twice a year. It is imperative that owners brush out the old undercoat so the new coat can grow properly. Although a dog may look fluffy and full, excessive undercoat may be causing serious skin problems.  In the show ring, the coat should be shown as completely natural; a brush through the coat is acceptable, but no trimming is allowed, not even of whiskers. However, any excessive undercoat should be removed. Some exhibitors choose to show dogs with excessive undercoat to make the dog's coat appear more lush. Failing to shed undercoat is considered neglect by some judges who prefer a clean and combed coat. Another exception is the hair under the bottom of the feet. The hair under the feet as well as the toe nails should be nicely trimmed for show.

Color.

Puppies are often described as looking similar to a red fox cub. They are born dark grey, black, brown, or fawn with a vast amount of black. A fawn-colored puppy or one with a large amount of white of the chest is not preferable for show purposes. The color of the adult dog can be assessed by an experienced breeder at birth, but even then, the color may change slightly as the puppy grows.  The adult color is typically a golden-red with variations from pale honey to dark chestnut. There is no preference for a particular shade as long as the color is bright and clear with no hints of dullness. The coat should never be a solid color. It should be shaded and without any defined color changes. The coat is usually at its darkest shade on the back of the dog, gradually getting lighter around the chest and belly. The undercoat must always be lighter in color than the topcoat, but is never allowed to be white. A small patch of white, no more than 1.5 cm (0.6 inches) wide, is allowable on the chest, and white tips on the feet are acceptable, but not desired.  The nose, lips, and rims of eyes should always be black.

Height and weight.

Height at withers (American Kennel Club breed standard):  Weight:

Temperament.

This breed is active, alert and lively. They need one or two long walks each day and will be fairly inactive indoors. This breed will not adapt well to a strictly kenneled living situation; they need a balance of outdoor exercise and indoor play time with the family.  Finnish Spitzes are considered to interact well with people and they are especially good with children. They are always ready to play with children but if ignored, they will usually walk away. As with all dogs, young children and dogs should always be supervised when together. It is an independent breed and will be attached to its family while remaining aloof with strangers. The Finnish Spitz tends to be protective; males have more domineering traits than females.  Most Finnish Spitzes get along well with other dogs in the house. They are bred as a hunting dog and thus are unreliable around small animals and pet birds, but on an individual basis may live well with cats, especially if they are raised with them.

Barking.

The breed barks at anything perceived to be out of the ordinary. Barking is a major part of their hunting activities. In Finland, these dogs are prized for their barking abilities, which can range from short, sharp barks to many barks per minute that sound like a yodel. The Finnish Spitz can bark as many as 160 times per minute. In Scandinavia, a competition is held to find the "King of the Barkers." In Finland, their barking ability in the field must be proven before a conformation championship can be earned.  When used as a hunting companion, the barking is a way to signal the hunter that the dog has located prey in the forest. They can be trained to reduce the amount of barking, although the barking does make them superb watchdogs.

Training.

Finnish Spitzes are independent, strong-willed, intelligent dogs. They are best trained with a soft voice and touch. This breed will not respond well to harsh training methods. They should be trained with a light touch and positive reinforcement methods. With patience and calm yet firm handling, the Finnish Spitz can be a wonderful companion.

Health.

The Finnish Spitz is typically a very healthy breed, with few general health concerns. However, breeders should be consulted to understand the prevalence of a specific disorder in this breed. Below is a short list of what is known to occur:  Median lifespan is about 11.2 years.

A Finnish Spitz (Finnish language: "suomenpystykorva") is a breed of dog originating in Finland. The breed was originally bred to hunt all types of game from squirrels and other rodents to bears. It is a "bark pointer", indicating the position of game by barking, and drawing the game animal's attention to itself, allowing an easier approach for the hunter. Its original game hunting purpose was to point to game that fled into trees, such as grouse, and capercaillies, but it also serves well for hunting elk. Some individuals have even been known to go after a bear. In its native country, the breed is still mostly used as a hunting dog. The breed is friendly and in general loves children, so it is suitable for domestic life. The Finnish Spitz has been the national dog of Finland since 1979.

芬兰狐狸犬()是一种源自芬兰的犬种。该犬种最早是培育用来打猎的。打猎时该犬种向着猎物吠叫,向猎人指明猎物的方向,同时也吸引猎物的注意力,以便让猎人更好的靠近猎物。在芬兰该犬种依然当作猎犬使用。该犬种友善且通常喜爱孩童,所以也适合当宠物养。自1979年起该犬种被选为芬兰国犬。