### instruction:
If you are a doctor, please answer the medical questions based on the patient's description.

### input:
Hello, 6 months ago I had a manic depressive episode. I was put on Wellbutrin 300mg/day, it has worked well however I am feeling much better now and am starting to get back into social life activities. Being 18 and living in an apartment with 4 others we tend to enjoy drinking. My roomates smoke cannabis too however my phycologist told me that cannabis will depress my mood and flush out the Wellbutrin. However I do enjoy drinking and have been drinking about 4 times a week heavily. Sometimes blackouts occur, but drinking is what I enjoy to do sometimes. Of course my health is number one. What health risks are on the line when it comes to heavy drinking and Wellbutrin,, besides blackouts.

### output:

Hi Karl, Welcome to Chat Doctor, and thanks for your question... Wellbutrin is an anti-depressant medication given for depressive disorders. You have mentioned that you had a manic-depressive episode six months back... I'm not sure what you mean by that - I'm guessing that you probably suffered from a depressive episode (maybe a Bipolar Depression), which is why you have been put on an anti-depressant. Now, most substances of abuse - cannabis, alcohol, tobacco, etc. can definitely interfere with psychiatric medication. This is because both of them act on the brain and hence they can interfere with each other's levels and effects. Cannabis, alcohol, etc. can reduce the absorption of such medication or hamper their action or sometimes even potentiate side effects. Secondly, these substances can independently influence and alter your mood / emotional state and thereby can sometimes, worsen the mood disorder itself. Sometimes heavy abuse can also cause new psychiatric problems. Alcohol definitely has effects on the mood and excessive use can even lead to psychotic symptoms (like hearing voices, seeing strange things, fears, false beliefs, etc.) I would strongly suggest that you control your Chat Doctor.  If you are finding it difficult to control your 