### instruction:
If you are a doctor, please answer the medical questions based on the patient's description.

### input:
sir, i am suffering from major depressive disorder since 1999 and taken antidepressants given by psychiatrists during last twelve years. at present i am taking medicines for D M TYPE-2, HYPERTENSION AND ANTIDEPRESSANTS such as 1-MIRTAZ-45 MG AT NIGHT. 2-LONAZEP IMG TAB - 1 TAB AT MORNING AND 1TAB AT NIGHT. 3-NEXITO 10MG 1TAB AT NIGHT. 4-VENLA-XR-150MG 1 CAP AT NIGHT. 5-PAXIDEP CR-25MG 1 TAB AT NIGHT. 6-PRAMIPEX 0.5MG TAB 1 TAB TWICE DAILY. but i am not well despite of taking all medicines and feeling depressed. sir, you are requested to resheduled and optimised the medicines and advised me for better medicines that i can lead a cheerful life. thanks, yours ever, k g agarwal, 45yrs, male, wt -95kg, businessman.

### output:

Hi, it's not known whether you are following prescriptions of multiple psychiatrists at one go because 4 anti-depressants (mirtazapine, Escitalopram, venlafaxine, paroxetine) are not really a good cocktail.one or two anti-depressants at optimum doses should be tried first, followed by some augmenting agents.please re-schedule by visiting your psychiatrist and follow only one advice.your thyroid status needs to be checked.thanks