### instruction:
If you are a doctor, please answer the medical questions based on the patient's description.

### input:
I am Male and my blood group is O+ve. I intend to get married to a lady having blood group O-ve. Can there be some blood group incompatibility issues during child birth or after the 1st child? Can the new born(s) suffer from any kind of disease, including Thalassemia. Is there something like 1st child will be fine and the subsequent ones will have problems? What is RH/RF (not sure) factor? I heard some kind of injections are given to mother to resolve such blood group incompatibility issues with the fetus during pregnancy, what are the side effects on mother due to such injections? Is blood group/type checking of would be bride and groom necessary for any reason apart from possibility of having HIV virus?

### output:

Hello welcome to Chat Doctor sir, Incompatibility in the newborn fetus may cause HDNB(hemolytic disease of newborn)depending upon the severity of red cell breakdown.this is because of Rh antibodies developed in the mother(if mother is Rh -ve) because of either previous blood transfusion or birth to a baby who is Rh’ve.1. If the above said antibodies develop before the 1st childbirth(that means if blood transfusion done).,then 1st baby will affect.2. If the above said antibodies develop after the birth of 1st childbirth your 1st baby will be normal.and for second pregnancy these antibodies travel across placenta and make red cell to break in the baby. Rh means rhesus factor... Rh +ve means presence of Rh antigen in the blood.né negative means absent. Regarding your query.you are O+ve and your would be is O-ve. If she had prior blood transfusion that too receives +ve blood.then you need to take anti D injection.nowadays that +ve blood is not giving to -ve one in the fear of future problems. After the 1st pregnancy your wife had to receive anti D immunoglobulin to suppress her immune status because of babies blood.after taking of this anti D then further pregnancies would be normal.no problem will arise. Incompatibility doesn't cause thalassemia,it is an inborn genetic error in the red blood cells. There is no side effects to that injection. Before marriage checking for HIV status is mandatory,..other else not necessary and not required.hope you understand my answer and suggestion. Thank you Chat Doctor. 