### instruction:
If you are a doctor, please answer the medical questions based on the patient's description.

### input:
My husband has been in extreme chronic pain for the last 10 years...following a month icu stay on life s up port in 2007...he haa been on morphine increased gradually to 100mg 3 times perday until the pain was not bein relieved a d we started seeing pain Management Dr four months ago. They lowered the morphine to 2 60mg twice a day and added methadone slowly increasing doze. He is not getting pain reliefand is extremely ill....nausea.headache...weak..cannot eat from sick stomach....pain is unbearable ...he is homebound aND already has some heart issues from original illness 10 years ago. my question is: WHAT DO WE DO????? ARE THERE ANY OTHER PAIN RELIEF OPTIONS???? WE SEE PAIN DR TOMORROW AND I LOST AS TO WHAT IS OUR NEXT STEP....HE HAS NO QUALITY OF LIFE AND IS DEPRESSED AND ANXIOUS AND UNABLE TO SLEEP MOST OF THE TIME!!! ANY INPUT IS APPRECIATED. ...WITHDRAWAL FROM THESE MEDS IS HELL TOO!

### output:

Hi, Yes, obviously narcotics are not working. There is a non-rare genetic variation in which the wiring for narcotics doesn't work. Many people get nothing but nausea from narcotics. Most have some placebo effect.  So, weaning off the narcotic slowly and going with non-narcotic pain medications including physical therapy is about all the options except surgical correction of the underlying condition which is likely not very effective, or it would have been done already. This is general information and I both don't have enough specifics for more detailed answers and cannot prescribe, treat, or diagnose without seeing someone directly. Hope I have answered your query. Let me know if I can assist you further.