Q. Can Seroquel withdrawal cause loss of sensation in penis?
Hello doctor,I finally withdrew from the drug called Seroquel. But now my penis has no sensation at all. I have much more arousal meaning my sex drive is back. But it is as though 90 % of the sensation is gone. While on Seroquel, I had more, but I stopped the medicine due to many bad side effects. It has been two weeks since my last dose.
Hello. Seroquel is Quetiapine, and the drug is an antipsychotic and mood stabilizer drug. In high doses in some individuals the drug is known to result in side effects like reduced libido, sometimes delayed ejaculation, difficulty in orgasm, etc. But Quetiapine is one of the safer antipsychotics if we compare this drug with other antipsychotic drugs.  The possible explanation of reduced sensation on the penis could be mild withdrawal, which might result in numbness like symptoms, and this may present with symptoms like reduced sensation around the penis. But the dose you were taking that is 50 mg is not a very high dose. Stopping this would not result in much withdrawal except mild insomnia. If we link this with sexual side effects of Quetiapine or Seroquel, then this will reverse by own in coming days. In most cases, sexual side effects go by own in less than four weeks of stopping the offending drug. You were not on a very high dose so that the recovery would be earlier. Prolactin levels increase seen with antipsychotic use (in high doses for a long duration, but some individuals even in low dosage). The standards will normalize in some days, and this will result in an improvement of sensation on the penis. No need to worry, and at this point nothing should be done because your erection is relatively better now, this means libido is improving.