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Synthesis of Atorvastatin Lactone
P. Sawant, M. E. Maier*
Universität Tübingen, Germany
16 February 2011 (online)
The enantioselective iridium-catalyzed transfer hydrogenative coupling of allyl acetate with an alcohol was used twice (A → B and C → D) in the early stages of a synthesis of atorvastatin lactone. A classical Paal-Knorr reaction was used to construct the pyrrole H.