Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles
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Objective: Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. Design and methods: We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. Results: Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P lt 0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR = 3.907; P lt 0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. Conclusions: Our r...esults indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.
Keywords:Renal disease / Haemodialysis / HDL size / Inflammation / C-reactive protein
Source:Clinical Biochemistry, 2011, 44, 8-9, 635-641
- Pergamon-Elsevier Science Ltd, Oxford