Collagen-induced arthritis impairs osteoclastogenesis and reactivity to sympathetic neurotransmitter stimuli in bone marrow-derived macrophages from DA rats
- Muschter Dominique, Schäfer Nicole, Straub Rainer H, Grifka Joachim, Grässel Susanne
- Department of Orthopedic Surgery, Experimental Orthopedics, University Hospital Regensburg, Germany, Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital of Regensburg, Germany, Department of Orthopaedic Surgery, University of Regensburg, Regensburg 93053, Germany
- Brain, Behavior, and Immunity SCI(E) SCOPUS
- Cited Count
Osteoclasts (OC) are key players in bone destruction in rheumatoid arthritis (RA). Recent work showed that catecholaminergic nerve fibers are reduced in RA synovial tissue. Studies on sweat gland innervation revealed that catecholaminergic fibers are capable of phenotypic transition to cholinergic nerves. The sympathetic neurotransmitters norepinephrine (NE) and acetylcholine (ACh) affect osteoclastogenesis oppositely and that is why we wanted to study osteoclastogenesis at different phases of collagen-induced arthritis (CIA) in an altered neurotransmitter microenvironment.
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