In hypertensive patients, once-daily administration of aliskiren at doses of 150 mg and 300 mg provided dose-dependent reductions in both systolic and diastolic blood pressure that were maintained over the entire 24-hour dose interval (maintaining benefit in the early morning) with a mean peak to trough ratio for diastolic response of up to 98% for the 300 mg dose.
Alimman pitoisuuden ja huippupitoisuuden aikaisen diastolisen vasteen välinen suhde oli 98% 300 mg: n annoksella.