In adults the dose should be reduced from 400 to 300 mg or from 600 to 400 mg, or from 800 mg to 600 mg, and in children from 340 to 260 mg/ m2/ day.
Aikuisilla annosta tulee pienentää 400 mg: sta 300 mg: aan tai 600 mg: sta 400 mg: aan tai 800 mg: sta 600 mg: aan vuorokaudessa, ja lapsilla 340 mg: sta 260 mg: aan per m2/ vrk.