Throughout the 1600s, the Palace took the form of a large Baroque palace at the will of three generations; the leading family members being Philip I, Cardinal Girolamo I and Lorenzo Onofrio, who relied on architects and artists of great skill and reputation.
Durante el siglo XVII, el Palacio asume la fisonomía de un gran palacio barroco por iniciativa de tres generaciones de familia, cuyos principales exponentes son Filippo I, el Cardenal Girolamo I y Lorenzo Onofrio, quienes recurren a arquitectos y artistas de gran competencia y notoriedad.