If interim kills are included in the study design, the number of animals in each dose group scheduled for an interim kill will normally be 10 animals per sex, and the total number of animals included in the study design should be increased by the number of animals scheduled to be killed before the completion of the study.
Si en el diseño experimental se incluyen animales para sacrificarlos durante el ensayo, lo habitual es que el lote sacrificado esté compuesto por 10 animales de cada sexo, y el número total de animales investigados se incrementará en esta misma medida.