They had thirteen children:* William Louis (1560-1620), stadtholder of Frisia (1584-1620), married Anna of Nassau (1563-1588)* John VII (1561-1623)* George (1562-1623)* Elisabeth (1564-1611), married in 1583 with Philip IV, Count of Nassau-Weilburg and in 1603 with Wolfgang Ernest I of Isenburg-Birstein,* Juliana (1565-1606)* Philip (1566-1595)* Maria (1568-1625), married John Louis I of Nassau-Wiesbaden-Idstein,* Anna Sibylla (1569-1576), died young* Mathilda (1570-1625), married Count William V, of Mansfeld-Arnstein* Albert (1572-1572), died young* Ernst Casimir (1573-1632), Count of Nassau-Dietz, stadtholder of Frisia and Groningen(1620-1632), married in 1597 with Sophia Hedwig of Brunswick-Lüneburg (1583-1642).
Tuvieron trece hijos:* Guillermo Luis de Nassau-Dillenburg (1560-1620), Estatúder de Frisia (1584-1620), casado con Ana de Nassau (1563-1588)* Juan VII de Nassau-Siegen (1561-1623)* Jorge de Nassau-Dillenburg (1562-1623)* Isabel (1564-1611), casada en 1583 con Felipe IV de Nassau-Weilburg y en 1603 con Wolfgang Ernesto I de Isenburg-Birstein,* Juliana (1565-1606)* Felipe de Nassau (1566-1595)* María de Nassau-Dillenburg (1568-1625), casada con Juan Luis I de Nassau-Wiesbaden-Idstein,* Ana Sibila (1569-1576), murió joven* Matilde (1570-1625), casada con el conde Guillermo V de Mansfeld-Arnstein* Alberto (1572-1572), murió joven* Ernesto Casimiro de Nassau-Dietz (1573-1632), estatúder de Frisia y Groningen (1620-1632), se casó en 1597 con Sofía Eduviges de Brunswick-Lüneburg (1583-1642).