Currently available data indicates that the peptidase activity of DPP4 is independent of the T-cell activating and co-stimulatory functions assigned to CD26. Of significance, however, is that in gene knock-out mice lacking CD26 there is enhanced insulin secretion and improved glucose tolerance.
Este tema debe ser resuelto antes de administrar inhibidores de DPP-4 en la práctica clínica. Sin embargo, es importante saber que en ratones "knock-out" sin CD26 hay una mayor secreción de insulina y una mayor tolerancia a la glucosa.