Mechanism of action Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol.
HMG- CoA on kolesterooli sünteesis olulisim ensüüm, mis konverteerib 3- hüdroksü- 3- metüülglutarüül koensüüm A mevalonaadiks, kolesterooli eellaseks.