Drug holidays, which mean stopping the drug for some interval of time—usually years, came about due to growing evidence that the extremely uncommon untoward conditions of osteonecrosis of the jaw and atypical femur fractures become more common with longer durations of treatment.
Ukuthatha ikhefu emayezeni kuthetha ukuyeka ukusebenzisa amayeza ixesha elithile—mhlawumbi iminyaka yaye kwaqalwa ukwenziwa ngenxa yobungqina obukhulayo bokokuba iingxaki ezimandundu ezingaxhaphakanga zesifo sokuqina nokufa kwethambo lomhlathi kunye nokwaphuka kwethambo lethanga ziyaxhaphaka xa olu nyango lusetyenziswa ixesha elide.