Some factors that come into play include: which organ is involved, how many organs are involved, chronicity of the disease, severity of the effect on the organ, evidence that the disease is active, likelihood of remission, evidence of progression versus stability, digression of symptoms and the patients' preferences.
Ezinye zezinto ezinenxaxheba ziquka: ukuba liliphi ilungu elichaphazelekayo, mangaphi amalungu omzimba achaphazelekayo, ubunzulu bokunganyangeki kwesifo, ubunzulu bokuchaphazeleka kwelungu lomzimba, ubungqina bokuba siyaphila esi sifo, amathuba okokuba siphinde sikuphathe kwakhona esi sifo, ubungqina bokuqhubekeka kwaso buthelekiswa nokuzinza kwaso, ukuphambuka kweempawu kuthelekiswa noko kufunwa sisigulana.