Generally speaking, Benadryl® is safe in all trimesters of pregnancy, but make sure it's Benadryl without pseudoephedrine.
I-Benadryl® liyeza elikhuselekileyo jikelele kuzo zonke izigaba zeenyanga ezintathu zokukhulelwa, kodwa kufuneka uqinisekise ukuba yiBenadryl engenayo i-pseudoephedrine.