Cardiac Autonomous Nervous System (CANS) function To test drug-related changes in the autonomic nervous function and their impact on the cardiovascular system the investigators will measure resting heart rate variability (HRV) (63) and perform Cardiovascular Autonomic Reflex Tests (CARTs), a modified battery of the Ewing tests. Using an automated, beat-to-beat blood pressure and ECG recording monitor (Nexfin®, BM Eye, Amsterdam, The Netherlands) heart rate and blood pressure will be recorded during: resting, taking deep breaths, exhalation into a mouth-piece with a measurable resistance (Valsalva maneuver) and standing up from a supine position. Information regarding changes in parasympathetic and sympathetic nervous system function can be derived from the measurements using dedicated software.