4 Randomization and Blinding: Simple randomization method by sequentially numbered, opaque sealed envelopes (SNOSE) will be conducted to ensure both the TWGHs counselors and the participants are masked from the allocation. The counselors who are responsible for the subject recruitment will be masked from the randomization. For each participant who is eligible for the study checked by the counselors, the counselor will call the site randomizer to allocate group identity for the participant by opening one sealed envelope according to the serial number sequentially and inform the counselor for further intervention. Assessors in the follow-ups will not be involved in the randomization process and be totally blinded to the group assignment (single blindness).