QTc (machine read) greater than 450 ms on the screening ECG. History of glucose intolerance (serum glucose greater than 110 mg/dl or 6.1 mmol/L after 8 hours fasting) Subjects have had treatment with a new molecular entity (investigational drug) or any other trial during the previous 30 days or five half-lives, whichever is longer. (the washout is from last dose of study medication in the previous study until the first dose of study medication).