The use of estrogens as adjuvant therapy in schizophrenia seems promising, although in long-term treatment it can have a potentially negative effect on breast and uterine tissue(20,21). This was the reason we chose raloxifene for our study, which is a selective estrogen receptor modulator (SERM) that can act as a tissue-selective agonist or antagonist. Raloxifene is a first-generation SERM used in the preventive treatment of post-menopausal osteoporosis and does not affect breast or ovarian tissue. (22). It has agonistic effects on the brain(23). Raloxifene seems to influence multiple neurotransmission pathways, including that of seratonin in the frontal cortex, basal and striated ganglia(24), areas of the brain that are commonly affected in schizophrenic patients.