Safeguards for vulnerable populations:Females of childbearing potential must agree to practice sexual abstinence or use a medically acceptable method of contraception for the duration of the study and for at least 1 month after the last day of test article administration Anticipated Benefit Study participants randomized to the medication group will receive the current best available treatment for onychomycosis. Participants who fail to be cured by this treatment will have the option to undergo treatment with the laser following the 6 month study visit. It is possible that participants randomized to the laser treatment will be more likely to be cured than the standard treatment.