Objectives The primary objective is to evaluate the effectiveness of bLF in the prevention of the first episode of nosocomial infection and sepsis of bacterial or fungal origin after admission to RCC. Secondary objectives are assessments of the incidence of pneumonia, urinary tract infection and sepsis, mortality prior to discharge (overall and sepsis-attributable), weaning rate from MV, total days of MV, alteration of immune system, cytokines and liver function, and adverse effects or intolerance.