Currently, the only method to diagnose CTE is through post-mortem brain examination, utilizing special immuno-staining techniques for tau protein deposits in NFTs and NTs. The ability to image tau protein collections in vivo in the form of NFTs would provide tremendous benefit for clinical management, treatment, and possibly prevention if a pre-morbid diagnosis could be confirmed. The implications for the sports communities, military organizations, and the general population, all of whom have potential exposure to MTBI, are tremendous.