Screening Subjects will be screened in the outpatient GCRC. Screening procedures will include thyroid stimulating hormone and late night salivary cortisol to rule out secondary causes of obesity and a basic metabolic panel to rule out other untreated medical conditions. Other screening tests will include a history and physical, to ascertain ability to initiate an exercise program. As part of the physical exam, a mini mental status exam will be performed to screen for cognitive impairment that would preclude them from participating in the mindfulness training curriculum.