5. Midazolam (0.075 mg/kg orally) with collection of 8 plasma samples over 6 hours (only for Phase 1) to determine CYP3A activity (MDZ CL/F mL/min). Samples will be drawn immediately after midazolam administration (0 minute), then at 5 minute, 0.5, 1, 2, 4, 5 and 6 hours. Breathing, heart rate, and oxygen saturation will be monitored via pulse oximetry for the first 90 minutes after midazolam dose.