Several reports have suggested that an endoscopic diagnosis of adenoma, by means of narrow band imaging (NBI), might allow the determination of polyp management and surveillance interval, particularly in patients with diminutive polyps (< 5mm), in which the advanced histological features are uncommon and the prevalence of invasive cancer is negligible (1). On this basis, the American Society of Gastrointestinal Endoscopy (ASGE) has set an initiative evaluating the applicability of real-time endoscopic polyp assessment in clinical practice (1), which states that: