Randomization After signed informed consent, a standardized data set will be collected from all participants at all participating institutions. Patients enrolled in the study will be randomized to groups (1:1 ratio) using an online stratified randomization tool, allowing instant assignment to treatment group 24 hours per day with concealment of allocation. Allocation to groups will be stratified taking into account factors that may affect outcome of treatment: 1) Sex: Male; Female; 2) Duration of symptoms <48hrs; >48hrs; and 3) Center.