After a month from the time they met with the investigator, each patient will meet with Research Assistant 1 (physician), who will collect the "Canker Sore Diary" and will give the patient a bottle with 30 tablets of active ingredients or of placebo, according to which group he belongs (Control or Study). The patient will receive six (6) more appointments (once every month). The whole series of appointments will be decided in advance. A few days before each appointment the Research Assistant 1 will telephone the patient and remind him when and where the appointment will be.