Hypermethylated genes that have been analysed in blood of CRC patients are e.g. SDC2, THBD, HIC1, RASSF1A. Hypermethylated SEPT9 has been analysed in a large prospective study to evaluate its performance as a screening marker, but this only revealed a sensitivity of 48.2% with a specificity of 91.5%. However when hypermethylated promoter regions are analysed in concert with others as part of a biomarker panel, markedly better performance has been reported. A biomarker panel composed of RASSF1A, APC, MGMT, and Wif-1 reached a sensitivity of 86.5% and a specificity of 92.1% for CRC detection.