continuous glucose monitoring by - CGMS The CGMS (Minimed Inc., Sylmar. Calif) is a portable device allowing continuous measurements of interstitial glucose concentration (IGC) by a disposable subcutaneous catheter, operated by a cable and monitor system. The system measures glucose values every 10 seconds and stores an average value every 5 minutes, providing 288 measures per day [26]. The system reports values in the range between 40-400 mg/dl (glucose values lower than 40 mg/dl are reported as 40 mg/dl and values above 400 mg/dl are reported as 400 mg/dl). The median correlation of the device to capillary glucose is 0.92, with 75% of the correlation values above 0.75, 96.3% of the reference values in the range of >216 mg/dl are accurate. Calibration and verification of IGC will be performed prior to all meals and at bedtime, according to capillary measured glucose levels by finger taps, using a conventional glucometer. Data will be downloaded by using CGMS solutions software, transformed to Excel datasheet, and analyzed by a Pediatric Endocrinologist.