Up to 6 dose levels of vemurafenib with sorafenib will be tested. Up to 5 dose levels of vemurafenib with crizotinib will be tested. Up to 6 participants will be enrolled at each dose level. The first group of participants will receive the lowest dose level. Each new group will receive a higher dose than the group before it, if no intolerable side effects were seen. This will continue until the highest tolerable dose of vemurafenib either with sorafenib or crizotinib is found.