- Darbepoetin alpha administration : Darbepoetin alpha (Aranesp) will be administered s.c. at the dose of 300 µg. The first dose will be given on day 28 and the following doses at 2-wk intervals around days 42, 56, 70, 84, 98, and 112 post-transplant. Once the target Hb (13 g/dL) has been attained, the dose of Aranesp will be reduced by half to 150 µg. If the Hb increases to > 14 g/dL, Aranesp will be withheld and resumed at the dose of 150 µg when the Hb decreases < 13 g/dL. If the Hb decreases to < 12 g/dL, the dose of Aranesp will be increased to 300 µg again.