In all arms incorporating BCG therapy, BCG maintenance according to the SWOG 8507 schedule is considered standard therapy following the initial 6-week study therapy induction portion (65). All patients on BCG-containing arms that have not relapsed in follow up should receive maintenance BCG weekly for 3 consecutive weeks given 3, 6, 12, 18, 24, 30, and 36 months after their initial BCG treatment. On BCG maintenance treatment days, BCG therapy will be administered in the form of 1 freeze-dried/lyophilized vial (TheraCys® or TICE®) reconstituted in approximately 50 mL normal saline instilled via foley catheter into an empty bladder and maintained in the bladder for 1-2 hours before voiding. Any decision to alter, abbreviate, or modify the standard BCG maintenance schedule is at the treating urologist's discretion. Any deviations from the standard BCG maintenance schedule will be recorded in the study database.