Ziprasidone has exhibited a low incidence of weight gain, and one analysis suggested it carries a lower liability for weight gain than other atypical agents. In an open-label study, patients whose medication was switched to ziprasidone from conventional antipsychotics, risperidone, or olanzapine exhibited improvement in the lipid profile. Ziprasidone has also demonstrated a low incidence of extrapyramidal symptoms and a low risk of prolactin elevation. It has been associated with modest prolongation (<10 milliseconds) of the corrected QT(QTc) interval on electrocardiography(ECGs) obtained during short-term, fixed-dose, placebo-controlled trials evaluating doses of up to 200 mg/day. A study evaluating QTc intervals at maximum steady-state plasma concentrations demonstrated a 9-14-msec greater increase in QTc interval with ziprasidone than with four other atypical antipsychotics, including olanzapine . The clinical relevance of this magnitude of change is unclear. No excess risk of cardiac sequelae was observed in the clinical development program (package insert for Geodon [ziprasidone], Pfizer Inc., New York, 2002).