A recent preliminary study supports the use of sitagliptin for inpatient glucose management. This trial included 90 patients with type 2 diabetes admitted to general medicine and surgery services. It randomized patients to one of three groups: sitagliptin alone, sitagliptin plus long-acting insulin (glargine), or a basal bolus insulin regimen. The study selected for patients with mild to moderate diabetes by including only patients with diabetes controlled by diet alone, any combination of oral antidiabetic agents, or a total daily insulin dose ≤ 0.4 units/kg prior to admission. Patients were eligible if their blood sugar was 140 - 400 mg/dl. Patients in all three groups received supplemental (correction) doses of rapid-acting insulin before meals and bedtime for blood glucose >140 mg/dL. Glycemic control improved similarly in all treatment groups, but 100% of the patients in the sitagliptin alone group required one or more injections of rapid-acting insulin to correct hyperglycemia (4). This result suggests that sitagliptin alone is insufficient therapy for treating hyperglycemia in this population. We will recruit a similar population of patients, and we will add metformin for improved blood sugar control. Our sitagliptin and metformin group will not receive supplemental doses of rapid-acting insulin as the purpose of this trial is to evaluate a regimen without the risk of hypoglycemia.