Prior to any study specific procedures, each suitable participant will be given written information about the planned procedures and schedule. Each volunteer will be provided sufficient time to consider participation in the study. Any questions about the study will be answered by trained personnel. If the volunteers are still willing and interested they will be asked to sign the informed consent form (ICF). Participants will be advised that they are under no obligation to enter the trial and that they can withdraw at any time during the trial, without having to give a reason.