All medication will be directly administered and observed by nursing staff in the fasting state per hospital routine. All anti-TB medications are given as a morning dose. For the antiretrovirals (as may be assayed in a subset of patients at the 12 week mark), nevirapine is dosed q12 hours and for efavirenz as an evening dose, whereby for efavirenz the C2hr level (relative to the timing of anti-TB meds) serves as the trough level and the C12hr as the peak. This sampling strategy minimizes the patient blood draws, and is similar to prior pharmacokinetic studies. A maximum of 10 ml will be obtained in heparinized tubes at each draw as up to 6 drugs will be required to be assayed by HPLC. Blood will be immediately centrifuged onsite at the Dispensary and plasma stored in sealed screw-cap tubes at -80°C with the subject's study identification number and week/time of blood draw. Batched plasma specimens will then be shipped to the University of Virginia for high performance liquid chromatography (HPLC) testing per established protocols.