Januvia (sitagliptin) is an FDA approved antihyperglycemic drug that inhibits the enzyme dipeptidyl peptidase 4 (DPP-4), which is an enzyme that is responsible for the breakdown of glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By blocking this effect, GLP-1 and GIP stimulates the secretion of insulin and suppresses the release of glucagon thereby normalizing blood glucose. The unique properties of this drug decrease the likelihood of hypoglycemia. Therefore, this drug is often used in combination of other antihyperglycemic medications to produce a synergistic effect.