Secondary Endpoints, percentage of cases that haemostasis after first administration of coagulation factors alone Assessment of surgical field after administration of trial medication Time to closure of chest after administration of trial medication Transfusion requirements in post bypass period in theatre Transfusion requirements in ICU first 12 hours Mediastinal drainage in ICU first 12 hours Coagulation study results at various sample times Requirement for chest re-exploration Ventilation duration in ICU Duration of stay in ICU