A previous systematic review and meta-analysis of randomised controlled trials (RCT), which included papers published before January 2004, found no evidence of an effect of MVM supplementation on infection rate [6] or duration [7] in older people. However, considerable clinical and methodological heterogeneity was present in the studies included in this earlier review. The investigators have updated this earlier systematically review of the evidence that MVM supplementation is effective in reducing the incidence of infection in older people. Sub-group analysis explored the effect site of residence (nursing homes or dwellings) of study participants, primary outcome measure (self report or clinical evaluation), and baseline micronutrients status of enrolled subjects [8].