In the early stage of the disease, starvation and weight loss can be interpreted as a coping strategy that relieves anxiety and depressive symptoms. If this coping strategy works, then the effect may decreases in line with the severity of malnutrition. There is almost a clinical consensus that depression / anxiety and cognitive impairment in AN is sequelae to malnutrition. But, it is a consensus that rely mainly on experimental studies of healthy subjects back in the postwar years observations from famine and from food programs in the 3rd World. Knowledge of the relationship between psychopathology and malnutrition in AN is still limited to a few and small studies with contradictory conclusions. In a recent study of hospitalized patients, no correlations between body mass index (BMI) and selected psychometric variables could be detected, with the essential limitation that it was a cross-sectional study of a population of patients with a narrow BMI range. To our knowledge, only one longitudinal study on changes in BMI and depressive symptoms have been published. In that study, mean weight gain was a significant predictor of reduced score in several of the "specific" eating disorder symptoms, such as concerns about diet, while weight gain was not a predictor of concern about body nor for depressive symptoms. To our knowledge, no longitudinal re-nutrition studies of the relationship between weight gain and anxiety or cognitive functions has been published.