The clinical presentation varies from amenorrhea and a sonographic picture of polycystic ovaries but with subtle phenotypic abnormalities or signs of hyperandrogenism, to advanced Stein and Leventhal syndrome with clinical heterogeneity as the rule. Moreover, women with PCOS might exhibit features of the metabolic syndrome, including impaired glucose tolerance (IGT), obesity and dyslipidaemia ,with their associated long- term sequelae, namely endometrial carcinoma, hypertension, type 2 diabetes (T2D) and cardiovascular disease.