Chronic Traumatic Encephalopathy has a classical distribution that differs than other forms of dementia, and sub-typing based on location and distribution is reflected in the recent Omalu-Bailes classification (8). The areas of involvement are the temporal and frontal cortices, in addition to the mesencephalon and upper pons, locus cereuleus, and substantia nigra. This distribution, along with the history of multiple exposures to MTBI, the age distribution, and anatomical patterns further distinguishes this condition from Alzheimer's disease and other forms of dementia. In addition, 70% of athletes diagnosed postmortem with CTE are positive for apolipoprotein A3 (8).