2. Cardiac Symptoms: Patients meeting the following criteria are not eligible unless cleared by Cardiology: 1. Uncontrolled angina within 3 months. 2.Diagnosed or suspected congenital long QT syndrome. 3. Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes). 4. Prolonged QTc interval on pre-entry electrocardiogram (> 460 msec). 5.History of significant bleeding disorder unrelated to cancer, including: Diagnosed congenital bleeding disorders (e.g., von Willebrand's disease) Diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies)