- History or presence of an abnormal electrocardiogram (ECG) that, in the investigator's opinion, is clinically meaningful for an unstable cardiovascular event. Screening QTcF interval > 480 milliseconds is excluded. In the event that a single QTcF is > 480 milliseconds, the subject may enroll if the average QTcF for the 3 ECGs is < 480 milliseconds. For subjects with an intraventricular conduction delay (QRS interval > 120 milliseconds), the JTc interval may be used in place of the QTcF with sponsor approval. The JTc must be < 340 milliseconds if JTc is used in place of the QTcF. Subjects with left bundle branch block are excluded.