This is a multi-center, open-label, phase Ib/II study. The aim of the phase Ib part is to estimate the MTD and/or to identify the recommended phase II dose (RP2D) for the combination of INC280 and buparlisib, followed by the phase II part to assess the clinical efficacy of INC280 single agent and in combination with buparlisib (BKM120), and to further assess the safety of the combination. A maximum of 10 patients (in the combination arm) and approx. 5 patients (in the single agent arm), who have received bevacizumab treatment before entering the study, will be enrolled in the phase II part. In addition, a surgical arm will start concurrently with the phase II part, to determine the PK/PD profile of the study drug combination in patients undergoing tumor resection for recurrent glioblastoma after 7 to 10-days treatment.