1. The plug should not be reinserted in case a moderate to serious AE is observed, e.g. rejection or immune reaction, moderate to severe conjunctival hyperemia, moderate to severe Intraocular inflammation, corneal Keratitis (see Table 5, State of the Art Safety Risks, Latanoprost for Glaucoma, Literature Based; Causes, Mitigation & Relation to EXP-LP plug).