OCT baseline and follow-up examinations will be performed in Prague (IKEM hospital) and Brno (Saint Anna hospital) and data will be send to the core lab in the Iowa Institute for Biomedical Imaging, The University of Iowa, USA for analysis. Iowa Institute for Biomedical Imaging is a research centre, which has extensive experience with the evaluation of coronary atherosclerosis. For the purpose of detailed analysis of the coronary arteries unique software for creating 3-D reconstructions of coronary arteries based on the fusion of angiography and optical coherence tomography was developed at this institution. This software enables exact assessment of plaque and lumen volumes. Software is protected by U.S. patent. Because of large volume of data and patients in this project, applications of such automated analytic tools are prerequisite of successful accomplishment.