Sepsis-induced immunosuppression affects all types of immune cells. Neutrophils are pivotal components of innate immunity and provide the first line of defense against invading microorganisms. After recruitment to the site of invading microorganisms, they phagocytose, kill and digest the microorganisms via well-orchestrated processes involving reactive oxygen species (ROS). However, neutrophils in sepsis demonstrate an immunosuppressed phenotype.(1) Reduced bacterial clearance, diminished production of reactive oxygen species (ROS), and impaired recruitment to the site of infection are the most prominent features.(2-4) Available data also reveal that neutrophil dysfunction develops prior to secondary infections, and patients with the most severely impaired neutrophil function carry the highest risk for secondary infections.(3) However, the mechanisms involved are still poorly understood.