Radiotherapy has been established through various robust lines of in vitro and in vivo evaluation to be capable of inducing ICD and anticancer immune responses. As an exploratory analysis, we will integrate lipidomics into the workflow. This has already been done in multiple disease settings and NSCLC has already proven to change lipid content in a quantifiable manner. The aim of this pilot study is to investigate the hypothesis that certain biomarkers of ICD that were identified in vitro or ex vivo are detectable in patient sera following radiotherapy and/or chemotherapy. Radiotherapy alone or concurrent cisplatin-doublet and radiotherapy will be investigated. The investigator will conduct this pilot study to gather initial data to build upon in future clinical trials, as there is no in vivo data available on this topic. Results will be published and used for future grant applications.