Statistical method: This is an open-label study. Patients who meet all inclusion/exclusion criteria for enrollment will be allowed to enroll in the study. Those patients entering the study during all the trial will be allocated to arm A or arm B. Assignment to treatment will be determined prior to Cycle 1 d1 using an interactive response system by mail at a central location. Patients will be sequentially allocated to arm A or arm B with a 1:2 ratio.