Good clinical practice For each patient entered into the study a Case Record Form (CRF) in compliance with Good Clinical Practice will prepared. This document does not coincide with the subject's clinical personal folder. It must be given all the data elements relevant to the study. The coordinator of the trial will provide a CFR copy in electronic format to the PU involved. The compilation and maintenance of CRF as well as data transmission to the scientific director of the WP are under the responsibility of the leader of the PU involved.