Individuals 18 years of age and older presenting to the Retina Service within the Department of Ophthalmology at the Casey Eye Institute of Oregon Health & Science University with signs and symptoms of DME will be evaluated for enrollment into this study. This pilot study has a planned enrollment target sample size of 28 subjects with DME. However, up to 35 subjects will be recruited as it is possible that after subjects sign the consent form they may not meet all eligibility criteria.