It is a study of clinical and interventional character, in which individuals who participate in the intervention will be selected for convenience of the project database entitled "Second Cycle Diagnosis and Intervention Food Situation, Nutrition and Noncommunicable Disease More Prevalent Population of the city of João Pessoa / PB ". They will be invited to participate in the intervention female subjects, overweight or obese, aged 20 and 59 years. The selected individuals will be distributed randomly into three groups: receive daily supplementation of 01 capsules containing 400 mg of vitamin E synthetic source (Group 1); receive daily supplementation of 01 capsules containing 400 mg of natural source vitamin E (Group 2); and receive daily supplementation of 01 placebo capsule (control group). Individuals of all groups will receive dietary plan respecting individual needs, in order to control weight during the 08 weeks period. This project aims to evaluate whether vitamin E supplementation may modify the methylation and microRNAs profile.