Prior and during the treatment, all patients will be undergone evaluation with complete medical history, physical examination, baseline blood tests, and imaging evaluations (positron emission tomography (PET-CT) and/or radiography, bone scintigraphy, computed tomography scan, magnetic resonance imaging, ultrasonography). Effects of the treatment will be monitoring by imaging analyses at every 3 months for lesions detected at diagnosis of lung and/or hepatic metastasis or every 6 months without detectable lesions before the treatment.