SD-101 cream [containing 3% or 6% or vehicle (0%)] will be applied topically, once a day to the entire body for a period of 90 days. Subjects will come into the study site to have a target wound assessed at baseline. Selected target wound must be at least a certain age and within a prespecified size range at study entry. Photographic confirmation of the target wound location will be collected at baseline, and the picture saved from the first visit will be used to confirm location of the target wound at subsequent visits. The subject will return to the study site for visits 2,3,4 and 5 (at 14, 30, 60 and 90 days respectively) to have the target wound previously identified at baseline, re-assessed for the level of healing. In addition, changes in itching, pain, Body Surface Area (BSA) coverage of blisters and lesions, and scaring of the healed target wound will also be assessed at each visit.