Chronic HCV infection often follows a progressive course over many years, and can ultimately result in cirrhosis and the need for liver transplantation or hepatocellular carcinoma. The decision to treat patients with chronic hepatitis C infection is based upon several factors including the natural history and stage of the disease and the efficacy and adverse effects related to therapy. As a general rule patients who are considered for treatment should have histologic and virologic evidence of chronic infection (i.e., HCV RNA detectable in serum) and an elevated serum ALT (1). Combination treatment with Interferon and Ribavirin is currently the best available treatment for chronic HCV infection. However, response to therapy is suboptimal and there are several side effects.