The aim of this study is to present and test a therapeutic approach for DSH that goes beyond single psychiatric diagnoses and that addresses the heterogeneity of DSH patients. It will combine elements from cognitive-behavioural therapy, problem-solving interventions and Dialectical Behaviour Therapy (DBT), since these approaches fit in with the needs of different DSH patients. Patients in which depressive thoughts and beliefs predominate may especially profit from the elements from cognitive therapy, while patients who primarily experience problems in regulating their emotions may especially profit from the elements from DBT. Patients in whom skills deficits predominate may especially profit from the elements from problem solving interventions. In addition to this combined treatment approach, attention will be given to specific developmental issues that play a role among adolescent DSH patients. Furthermore, knowledge of risk factors for (repetition of) DSH will be incorporated in the treatment.