Current strategies for chronic wound healing are limited to topical ointments/therapies, allografts/xenografts with or without cell impregnation, dressings, and wound healing devices. None of these current modalities have been shown to be clearly more effective than another [3,4]. Currently, oral medications have not been examined for healing of these chronic ulcerations. Particularly, antihyperglycemic medications have not been studied specifically for the purpose of wound healing. Glucose control and wound healing have been shown to be related [5-7]. However, it is thought that wound healing as a result of tighter glucose control is merely a global effect rather than a direct result of the medications utilized with no evidence that indicates that a specific antihyperglycemic medication works better than another. Further, the mechanism of how and why this relationship exists is not well understood. Specifically, how the microenvironment of the wound as evidenced by changes in the biomarkers has not been delineated.