Secondary objectives: 1) To compare the average of steps per day at 12 months in patients with moderate-very severe COPD between the intervention group (conventional treatment plus health education program) and the control group (conventional treatment); 2) to compare the daily minutes of moderate to high intensity at 12 months between the intervention and control groups; 3) to compare the daily energy expenditure higher than 3 metabolic equivalents (METs) at 12 months between the intervention and control groups; 4) to compare the distribution profile of the daily physical activity (very sedentary, sedentary, moderately active) at 12 months between the intervention and control groups; 5) to evaluate the long-term effect of the health education program on the health-related quality of life of patients with moderate to very severe COPD; 6) to analyze the effect of the health education program on the risk and powered rate of moderate or severe COPD exacerbations; 7) to assess the relationship between the change of the PAL and the modification of the health-related quality of life and the number of moderate or severe exacerbations; and 8) to identify the determinants of a clinically relevant increase of the PAL (> 0.14 units) in patients with moderate to very severe COPD.