Paraffin-embedded biopsy specimens will be collected from all patients entered in this trial. In part of the patients, biopsies will be taken after injection of the hypoxic marker pimonidazole and the S-phase marker iododeoxyuridine (IdUrd). Sections will be immunohistochemically processed and stained for various combinations of vascular markers, endogenous hypoxia and proliferation markers and, if applicable, for pimonidazole and IdUrd. The sections will be analyzed by computerized image processing. Apart from overall single parameter values that will be obtained, the interrelationship of the various parameters will be studied and the microregional phenotype of the tumors will be characterized by quantification and integration of the marker profiles. The information thus obtained will be related to treatment outcome in terms of both local control and survival and results from the two treatment groups will be compared.