Reviewing the literature, dynamic contrast-enhanced MRI has been used to evaluate the potential of vertebral fractures in MM [Scherer et al, 2002a & 2002b], to quantify significant changes of BM microcirculation during conventional treatment [Rahmouni et al, 1993] or treatment with thalidomide combined with chemotherapy [Wasser et al, 2004], which may be a novel and non-invasive tool to approach the clinical outcomes of MM patients [Moehler et al, 2001]. In short, MR imaging of the spine was performed with a 1.5-T superconducting system (Magnetom Vision Plus; Siemens, Erlangen, Germany). A phase-array spine-coil was used, and a routine fast spin-echo T1-weighted sequence (repletion time msec/echo time msec, 600/12; turbo factor of three; section thickness, 4 mm; field of view, 28cm) was performed in the midsagittal plane and covered the area from T11 through the sacrum. A dynamic contrast-enhanced MR study was then performed (section thickness, 10 mm; field of view, 28 cm) at the midsection of the vertebral body and covered the same area. The pulse sequence used was a turbo fast low-grade shot gradient-echo sequence (8.5/4.0; prepulse inversion time, 160 msec; flip angle, 10°; acquisition matrix, 72x128). Acquisition time was 0.89 second with 0.11-second delay. In total, 100 dynamic images were obtained within 100 seconds (one frame per second) in each subject. After the initial 100-second scanning, the scanning were prolong to 600 seconds with the scan rate 1 frame per 10 seconds (1 seconds scan and 9 seconds delay). An injection of 0.1 mmol per kilogram of body weight gadopentetate dimeglumine (Magnevist; Schering, Berlin, Germany) was administrated by the power injector through a 21-gauge intravenous catheter that was inserted in the right antecubital vein previously. A brief constant injection rate of 2.0ml/sec were used. This injection was immediately followed with a 20-ml saline flush at the same injection rate. Dynamic imaging started when the injection of the contrast material commenced.