• Midazolam phenotyping assay: Blood samples will be analyzed to determine plasma concentration of midazolam, 1-hydroxymidazolam, and 4-hydroxymidazolam. Analyses will be performed at Oneida Research Services, Inc. using a proprietary LC/MS/MS method. Midazolam clearance will be used to reflect CYP3A activity and clearance will be determined by using non-compartmental analysis of midazolam plasma concentration-time data. WinNonlin® 3.1 will be used for pharmacokinetic analyses.