Participants are required to attend 6 clinic visits over a blinded treatment period of 52 weeks. Informed consent will be obtained from the participant prior to the commencement of any study procedure at the first clinic visit. If participants are eligible, they will be asked to return at the end of the screening period to be randomized and commence treatment. During the treatment period, participants will take one capsule daily (placebo or DHEA 50 mg). All participants will return to the clinic 5 more times, at weeks 0, 12, 26, 38 and 52 for assessments of efficacy and safety. Blood tests will be collected at Weeks -4, 0, 12, 26 and 52 to assess safety and hormone levels. Prior to commencing the study, participants will require a mammogram if this has not been done within 12 months of study entry. A transvaginal ultrasound will be performed to assess endometrial thickness prior to commencement of the trial. A Papanicolaou smear will also be performed if the cervix is still present, in those women where a Pap smear has not been done within 12 months of screening. These investigations, except the mammogram and Pap smear, will be repeated at the completion of the study. All participants will have a complete physical examination which will include an assessment of vital signs, breast examination, and internal and external pelvic examination to assess for clitoromegaly (clitoral enlargement). Skin evaluations for scalp hair loss, hirsutism and acne, and assessment for voice changes will be made throughout the study. Participants will be required to complete various questionnaires to assess sexual function (SSS), menopausal symptoms (MENQUOL Intervention) and general well-being (PGWB) at Weeks 0, 12, 26 and 52. Participants will also record satisfactory sexual events in a 28 day diary which will be done in the 4 weeks prior to Weeks 0, 12, 26 and 52.