The responsible physician will inform the patient about the background and current knowledge of the treatment under study with special reference to known activity and toxicity. The patient will be told about the investigative nature of this treatment and in particular, the randomization process involved in this study. The patient will be told of his or her right to withdraw from the study at any time without any penalty with regards to the continuation of care at this institution and by the same physicians as he chooses. Before accrual, all patients will sign a written, informed consent form.