In insulin-treated type 2 diabetes the relationship between endogenous insulin levels and both glucose variability and hypoglycaemia risk is unclear. An association between endogenous insulin levels and hypoglycaemia risk was reported in the United Kingdom Hypoglycaemia Study, and those with low endogenous insulin levels have increased post-meal glucose rise (a measure of glucose variability and therefore hypoglycaemia risk). However, in another large cross-sectional study there was no correlation between endogenous insulin levels and questionnaire-assessed hypoglycaemia risk.