- Immune cell-associated anti-tumorigenic cytokines or chemokines as positive biomarkers IL1B, IL12p70, IL15, IFNG, IL22, IL23, IL17A, IL2, CCL4, CCL5, CXCL13, CCL8, CCL19, CXCL11,CCL12, CCL17, CCL23, CCL22, CCL13, CCL24, CCL1, CCL26, CXCL2, CXCL16 Moreover, the investigators will also investigate serum-associated exosomes as possible biomarkers of an efficient antitumor response. Compared to certain soluble biomarkers (which are accessible and thus more susceptible to extracellular proteases), exosomal biomarkers can exhibit a longer half-life than their soluble equivalents, due to the "protection" provided by their encompassing lipid membrane. Therefore, the investigators are also interested in exploiting exosomes as a source of antitumor response information and as novel biomarkers of therapeutic success (those mentioned above and others under investigation).