All adult patients with the diagnosis of sepsis who will be admitted to the Trauma and Surgical Intensive Care Unit (SICU) of Kasralainy School of Medicine,Cairo University during a 6-month period (from March 2017 to September 2017) will be enrolled in the study.Sepsis is defined according to Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2016 as life-threatening organ dysfunction due to a dysregulated host response to infection.10 Septic shock is defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities substantially increase mortality.