Ten mL whole blood venous EDTA samples will be collected from radial artery catheter at five specified occasions: before induction of anaesthesia, 30 minutes after aortic cross-clamp positioning and 3, 6, and 9 hours after aortic cross clamp positioning. The blood samples will be subsequently centrifuged at 4 °C for 15 min and the serum stored at −70 °C. Samples will be analyzed for the following markers: Polimorphonuclear Neutrophil Elastase (PMNE), Interleukin-1α (IL-1α), Interleukin-1ß (IL-1ß), Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), Interferon-γ (IFN-γ), Tumor Necrosis Factor-α (TNF-α), Vascular Endothelial Growth Factor (VEGF), Monocyte Chemoattractant Protein-1 (MCP-1), and Endothelial Growth Factor (EGF).