Preparation of vaccine will be performed under the principles of Good Manufacturing Practice. The lyophilized peptides are manufactured in an eight arm multiple antigenic peptide (MAP) in a commercial facility specialized in peptide synthesis and structure modification ( .e.g AnaSpec USA). Peptides will be dissolved in PBS made for human use. The whole procedure will be done in sterilized areas of drug/vaccine industry ( e.g. VACSERA, MOH Wezaret Al Zera'a street Agouza). The lyophilized peptides will be stored in regular fridge, while dissolved peptides will be stored at -80 0 C as aliquots ( in sealed ampoules each contains 1X dose) ready for injection and transported to the hospital in dry ice just before use. Note : These storage and transportation precautions are followed during these early stages of the study. While the strategy would be modified at a commercial scale when the current product proves effective. In this later case a lyophilized powder with the recommended dose will be packaged in a sealed ampoules and dissolved just before use. HCV peptide vaccine Cenv3 will be injected subcutaneously in 3 different doses ( 1x i.e. 324 ug , 2x i.e. 648 ug or 3x 1296 ug/ 70 kgm body weight adult). It should be noted here, that dose 1X equals to the calculated pharmaceutical dose from mice experiments, therefore 324 ug/ 70 kg body weight is the Minimum Available Biologically Effective dose Level (MABEL). Based on other laboratories experience with peptide vaccine administration to man ( Tanaka and Manns) who used up to 5000 ug of peptide vaccine for their immunization experiments. The highest dose used in our protocol is 4X ( 1296 ug/ 70 kg bw) and therefore considered the No Observable Adverse Effect Level ( NOAEL) in this protocol. The vaccine will be administered either as a MAP form ( self adjuvanted) or supplemented with adjuvant ( MF59) in a common protocol of monthly injection for 3 consecutive months.