Multiple myeloma (MM) is a clonal plasma cell neoplasm characterized by proliferation of abnormal plasma cells in bone marrow (BM) that secrete a monoclonal paraprotein (M-protein) in serum and/or urine, and by osteolytic bone destructions. So far, it is an incurable disease and its pathogenesis is largely unknown. The median survival time of MM patients is only three to four years, and then the patients will die on either the disease or its complications [Barlogie et al, 2004].