The decision to continue immunosuppression therapy will be at the discretion of the site PIs. Mycophenolate mofetil may be dosed down to half or discontinued prior to the end of the study period if the subject experiences adverse reactions to the immunosuppressive agents. If adverse reactions still persist, tacrolimus dose can be further reduced in half and then further considered to be discontinued. Any or all of the immunosuppressive agents may be reduced or stopped at the discretion of the site PI if it is suspected or determined that the immunosuppressive agent is the cause of toxicity and if symptoms of toxicity cannot be managed adequately with symptomatic treatment.