Investigators have shown that the analysis of VOCs separates adult patients with diarrhoea-predominant irritable bowel syndrome (n=30) from those with active CD (62) and UC (n=48; sensitivity of 94% and 96% and specificity of 82% and 80% respectively; p<0.05). Our data in adults strongly suggests that VOCs differentiate CD from UC, and also Crohn's colitis from UC (Ahmed 2013). More recently, research has shown that VOCs also distinguish between active and inactive CD and UC in adult patients (Ahmed 2016).