As there is a very narrow time window between identification of eligible participants and consent to participate to the study, and considering the need for immediate initiation of treatment in patients with active disease, it is anticipated that signed consent to join the study will be obtained on the same day of receiving information about it; however there will be subsequent opportunity to review this decision. Consent will only be taken if participants feel they have had adequate time to make this decision, and no pressure will be applied in any way.