In all arms incorporating BCG therapy, induction intravesical BCG will be administered weekly x 6 doses starting on Cycle 1 Day 1 in the form of 1 freeze-dried/lyophilized vial (TheraCys® or TICE®) reconstituted in approximately 50 mL normal saline instilled via foley catheter into an empty bladder and maintained in the bladder for 1-2 hours before voiding. Treatment will begin at full-dose BCG. A one level dose reduction will be implemented if certain DLT criteria are met.