HEALTH ECONOMICS: The EuroQol (EQ−5D) instrument will be used as the main measure of health−related quality−of−life in the economic evaluation [9]. It has been developed by a collaborative group of European researchers as a preference−based index, suitable for the calculation of QALYs. The EQ−5D is one of two instruments currently recommended for use in economic evaluations [8]. Information on patients' use of health services will be collected by a review of hospital notes, patient recall and a home diary issued to all study participants. The resources included will be: hospital admissions, inpatient days, ITU days, outpatient consultations, A&E attendances, and primary care surgery and home visits.