The fundus photographs will be graded at 12.5x magnification, according to the International Classification and Grading System for ARM and AMD (The International ARM Epidemiological Study Group, 1995). In this system, all ARM fundus signs within a standard circular area (diameter 6,000 m) around the fovea will be recorded. Graders, trained according to the Wisconsin ARM grading system will grade the photographs blinded to the patient information.