The inclusion and exclusion criteria for Part 2 will be the same as for Part 1 of the study. The number of subjects to be enrolled for this part will be decided after the completion of Part 1. About 12 to 21 patients will be randomized if no Dose Limiting Toxicities (DLTs) are observed in 2 subjects at any dose level to 1 of the 3 groups (Groups 1, 2, and 3) as below: