Patients will be entered into the trial by a telephone call to the National Medical Research Council (NMRC) Clinical Trials & Epidemiology Research Unit (CTERU), Singapore (+65 220-1292) between 0830 to 1730 hours Monday to Friday, and 0830 to 1230 hours Saturday (Singapore time), or by Fax (+65 220-1485), stating that the patient is to be entered into the CTRG L08 or SQLU02 trial.