High potency sucralfate is the active ingredient of ProThelial. At standard 14mg/kg doses, high potency sucralfate causes a 7-23 fold hyper-concentration of sucralfate on mucosal lining. In a placebo controlled, double blinded multi-center trial involving 60 patients, there was a 28 day 87.7% healing rate of GERD erosions (compared to placebo's 37.7%) in patients using high potency sucralfate at 1.5 gram twice daily. This represented a 2.34 fold or 334% improvement in healing over placebo. Esophageal erosions in both treatment groups were exposed to untreated gastric acid making the results observed with high potency sucralfate that much more remarkable.