Patients enrolled in this protocol will have been referred with a known or suspected inborn error of metabolism, heritable disorder, or genetic predisposition. Examples include inherited developmental defects or diatheses toward infections, cancer, or an environmentally induced disease. The principal investigator, along with consulting specialists, will review the medical records of prospective subjects and offer admission based upon the potential to help the individual, to learn from the patient, or to initiate clinical or basic research suggested by the patient s workup. Prior to late 2008, patients enrolled in this protocol had disorders of current or potential future research interest to the Principal Investigator or an Associate Investigator. Approximately 400 such patients were enrolled over the course of 32 years.