This is a prospective randomized controlled study. Eighty stroke sufferers with unilateral weakness will be enrolled in Chang Gung Memorial Hospital at Linkuo. They will be randomized into two groups: combined training (CT) and usual rehabilitation (UR). Participants in the CT group will receive supervised aerobic training at moderate intensity in addition to usual neuro-rehabilitation, in which motor control and task-oriented ADL training are the major contents. Patients in the UR will undergo usual neuro-rehabilitation only. The aim of the present research is to evaluate the efficacy of an aerobic training program at moderate intensity for a total of 20~25 sessions using a semi-recumbent stepper with constant power design. Pre- and post-training measurement includes (I) cardiopulmonary fitness, (II) daily activities dependency, (III) coagulation and fibrinolysis profile. [the 1st year] (IV) monocyte subsets and its interaction with platelets [the 2nd year]. (V) Systemic inflammation, platelet activation and prognostic biomarker：C-reactive protein, soluble P-selectin, asymmetric dimethylarginine, Lipoprotein-Associated Phospholipase A2, etc. [the 3rd year]. Venous blood will be sampled two times before and after rehabilitation.