Liver fat content, pancreatic fat content, visceral and subcutaneous fat content will be assessed by magnetic resonance imaging (MRI) proton density fat Fraction (PDFF) at the beginning of study and again after 12 weeks of intervention. PDFF is emerging as a leading MR-based biomarker for noninvasive quantification of hepatic steatosis (3, 4). Multiple human studies have shown that this method accurately estimates PDFF in the liver. Based on these results, this magnitude-based PDFF estimation method now is being used to quantify liver fat in clinical practice in several institutions in the United States and is being used as a biomarker of drug efficacy and drug toxicity by the National Institutes of Health (NIH) and industry in clinical trials (5, 6). This method has been shown to be both accurate, and reproducible (7).