6. Require systemic pharmacologic doses of corticosteroids greater than the equivalent of 10 mg/day; replacement doses, topical, ophthalmologic and inhalational steroids are permitted. Subjects who have a history of adrenal insufficiency and are receiving greater than 10 mg/day coticosteroid may be eligible but only after Sponsor consultation. Subjects who are currently receiving steroids at a dose of ≤10 mg/day do not need to discontinue steroids prior to enrollment.