Follow-up and outcomes All included patients were clinically followed to monitor adverse effects of angioedema, gastrointestinal symptoms, rash, gout, hypotension, and renal stone at initial examination, 1 week, 4 weeks, 8 weeks, 16 weeks, and 24 weeks. The following laboratory data were collected during the same period: potassium, electrocardiogram, creatinine, uric acid, and urine analysis. Echocardiographic evaluation, peripheral tonometric measurements of peripheral PWV, central aortic blood pressure and augmentation index, cardiac magnetic resonance imaging (cardiac MRI), and biomarkers were analyzed at baseline and after 24 weeks of treatment.