All consent and paper data collection forms will be scanned onto discs and stored in locked filing cabinets within the controlled access ECRF for the duration of the project. Paper copies will be shredded. Where permission has been obtained, samples and data will be transferred for safe keeping to the Exeter Tissue Bank (ETB) Where no such permission has been obtained at the end of the project the study documentation will be archived and stored following the standard R&D archiving procedures and biological samples will be destroyed following standard clinical guidelines for sample destruction.