Secondary The main objective of the study is to determine the metabolomic basal levels in patients with renal cell carcinoma clear cell and try to find out a prognostic profile Metabolomic profile changes during the follow up. Tumour progression and PFS, i.e. the time from surgery/first line treatment to progression RCC specific survival time, i.e. the time from first line treatment to death from RCC Overall survival, i.e. the time from first line treatment to death from any cause, including RCC Best response Toxicity and association with metabolomic profile evaluation. Metabolomic characteristics of resected primary RCC. Tumour samples will be examined for a relevant metabolomic profile, and their association with outcome will be studied.