Recent literature has studied the role of restricted cerebral blood flow and inflammation on perpetuating the symptoms of a concussion. Meier et al. discovered an inverse relationship between cerebral blood flow in the dorsal midinsular cortex and the time to return to play. Other studies have investigated the role of inflammation, through the production of reactive oxygen species, that not only contribute to the initial injury but also potentiate its own pathological course. These studies highlight potential mechanisms that could be targeted to decrease symptoms and improve outcomes.