The different layers of the placenta have been studied, and it has been found that the amniotic membrane has a high hydraulic conductivity, thus facilitating its use in bleb repair following glaucoma-filtering surgery.14 Amniotic membrane transplantation is currently being used for a continuously widening spectrum of ophthalmic indications. Amniotic membrane transplantation has been shown to be effective in the reconstruction of the corneal surface in the setting of persistent epithelial defects, sterile corneal ulcerations, and partial limbal stem cell (LSC) deficiency states, including those secondary to chemical or thermal burns. The amniotic membrane has several properties that promote epithelialization and reduce inflammation, and these have prompted its use in the management of persistent epithelial defects,15,16 deep ulcers,17,18 neurotrophic ulcers,19 and perforations,20,21 with initial success rates varying from 50% to 90%. Multiple layers of AM restore stromal thickness in deep and perforated noninfectious ulcers and probably provides a substrate for collagens and growth factors for epithelial healing. AMT was also used for huge pterygium or recurrent pterygium.27 The limitations of AMT include continuous tissue destruction beneath the graft, the need for adequate stem cells at the limbus and normal keratocytes in the surrounding tissue, and intact sensory innervation for healing.15 In mild to moderate chemical injuries, AMT restores corneal and conjunctival surfaces. It prevents symblepharon formation in severe burns.22,23 In severe cases, owing to extensive ocular surface inflammation with deep stromal ischemia and near-total destruction of the limbal stem cells, the amniotic membrane may at best reduce inflammation, prevent further stem cell damage, and prevent symblepharon formation in the acute stages. Joseph et al 24 describe the complete failure of AMT in 4 cases of acute grade 4 chemical burns with complete loss of vision in all.