Except for its BP lowering effect aliskiren was found to increase renal blood flow to a higher degree than that was found for angiotensin converting enzime (ACE) inhibitors or angiotensin receptor blockers (ARBs). Moreover- it blocks the active site of the prorenin/renin ((pro)renin) receptors reducing the local angiotensin II (AII) generation. Renin inhibitors, like the ACE inhibitors or ARBs, increase the concentration of renin which activates the (pro)renin receptors. Renin receptors were found in the kidney, blood vessels and the heart. Binding of renin to these receptors increases its catalytic effect and probably activates a potentially pathogenic, mitogen activated protein kinase pathway. It has a tissue damaging effect by increasing frofibrotic pathways and the expression of molecules such as TGF- beta.