BACKGROUND. Chronic kidney disease (CKD) affects millions of people worldwide. Cardiovascular (CV) events cause more than 50% of the mortality risk in CKD patients, and the relative excess mortality is observed in younger patients, below 45 years of age. Decreased renal function led to changes in biochemical parameters (calcium, phosphorus, PTH and vitamin D levels) and disturbed mineral metabolism, which translates into different bone disorders (related to bone turnover, mineralization, and volume) and all these are associated with extra-skeletal calcifications. Bone disease at any stage of CKD is associated with CV morbidity. This cross-talk between bone and vessels constitute a systemic syndrome known as CKD-mineral and bone disorder (CKD-MBD), that is thought to be one of the major non-traditional risk factors for the extremely high rate mortality observed in this disease.