There are well-developed FH Registries in the Netherlands, United Kingdom, Spain, France, and the US, through the newly established US FH Foundation. In the United Kingdom, a report on the economic advantages of treating FH revealed that lipid-lowering statin therapy would lead to 101 fewer cardiovascular deaths/1000 patients with FH given treatment. The cost saving from cardiovascular events is estimated at over $CAN 592 million in the UK if all relatives of index cases were identified and treated, compared with no treatment given. This cascade testing strategy has been successfully applied in the Netherlands in families of FH probands with a detected mutation, thus allowing statin treatment of family members at risk of early coronary heart disease.