4. History of bleeding diathesis or known coagulopathy such as; impaired hemostasis: known international normalized ratio (INR) >1.5; past or present bleeding disorder (including congenital bleeding disorders such as von Willebrand's disease or hemophilia), acquired bleeding disorders, and unexplained clinically significant bleeding disorders; thrombocytopenia (platelet count less than 100,000/µL), or history of thrombocytopenia or neutropenia associated with clopidogrel.