This study would seek the approval from the Ethical Committee, College of Dentistry, King Saud Bin Abdul-Aziz University for Health Sciences (KSAU-HS) and Ethical Committee of King Abdullah International Medical Research Center (KAIMRC). Investigators having direct patient contact Would be sensitized according to the International Conference of Harmonization's Good Clinical Practice (ICH-GCP). Before the study, participants would be informed about the study objectives and their signed informed consent would be obtained.