As lateral epicondylitis involves a cascade of injury at or about the insertion of the common extensor tendon at the fibro-osseous junction, the patho-physiologic response to proliferation at this joint seems promising. Based on previous studies, prolotherapy would theoretically strengthen and stabilize the overstretched and torn strands of fibrous tissue that cause the cascade of instability and generation of pain at this junction. Not only would prolotherapy thereby improve subjective pain, it would improve objective strength and stability of the joint with resultant increase in function. Moreover, in doing so, prolotherapy would benefit both the patient and society at large by offering a relatively safer, less expensive, and longer lasting alternative to corticosteroids.