All subjects will undergo three additional outpatient or inpatient GCRC visits: #2) at the time of completion of the 6-week mindfulness training, #3) at the time four weeks after the final refresher course and #4) at the time three months after the final refresher course. The subjects of both the control and treatment groups will undergo GCRC visits during the same two-week period. All measures obtained at the first visit will be repeated. All subjects will have one-hour meetings with the GCRC dietician for weight loss counseling at each visit. The purpose of these GCRC visits or admissions will be to determine the immediate effects, short-term effects and long-term effects of the intervention on metabolic, inflammatory, and adipocytokine parameters. Out-patient subjects will be given their questionnaires in advance so they can complete them at their convenience and decrease the time required for their out-patient visits.