Inclusion and exclusion criteria's are described below. The patients recruited will be stratified according to age, sex and identified risk factor, then they will be randomised into two different treatment strategies a) Enhanced treatment support (ETS) strategy (described below) and Conventional treatment (CT). The patients treated under the two strategies will be compared with respect to: (i) virological treatment failure, (ii) patient's adherence to treatment strategy, (iii) physical development, and (iv) mortality and AIDS event. First drug regimen for all patients includes stavudine or AZT, lamivudine, nevirapine or efavirens. All procedures, treatment, and follow up for adverse effects are done according to national guidelines. The health care workers are trained in regular monitoring of patients and implementation of optimal treatment strategy. All procedures and treatment will follow the national guidelines. Follow up visits including physical examinations, adherence evaluation and laboratory tests will be done every 3 months.