Currently, there is no empirical evidence of the significant superior efficacy of particulate water via large volume nebulizer (LVN), in providing humidity therapy to spontaneously breathing tracheostomy patients over molecular water via heated humidifier. Large volume nebulizers are a commonly used therapy in clinical practice for tracheostomy patients. However, in terms of an optimal modality for providing humidification when the upper-airway is bypassed, there is much controversy. Much of the available literature has looked into a comparison between heated humidity (HH) and heat and moisture exchangers (HMEs) in intubated patients in crossover studies and case studies. In addition, they have seen overall greater outcomes in HH. Nonetheless, no recent studies have directly compared the use of HH and LVNs during humidity therapy in spontaneously breathing tracheostomy patients. Although a couple of past studies have directly compared the two humidity types in spontaneously breathing patients with a bypassed upper airway, no research has been conducted as follow-up to these past studies. Furthermore, these studies were restricted to outcomes of arterial oxygenation and also had limitations due to the short duration of the studies and small sample sizes.