Patient has a bilirubin level > 2 X Upper Limit of Normal at screening. Patient has had radiotherapy in the 12 weeks before screening. Patient has used depot corticosteroids in the 6 weeks before screening. Patient has had chronic use of any systemic corticosteroids (> 10 mg per day of prednisolone or equivalent for a period of 2 weeks or more) and/or immunosuppressant drugs (such as azathioprine, tacrolimus, cyclosporin) within the 2-week period before the first administration of study drug.