Both in patients treated with Lenograstim (rhu G-CSF, Myelostim 34, Italfarmaco) and in patients treated with placebo, immediately before the first dose of Lenograstim (rhu G-CSF, Myelostim 34, Italfarmaco) or placebo and in the morning of the last day of treatment in which the peak of BMSC mobilization is expected, an echocardiogram using an echocardiographic contrast agent (Sonovue, Bracco) will be performed in the days of administration of the drug or placebo, ECG, blood pressure, blood count and coagulation analyses will be monitored.