Most individuals exhibit circadian variation in blood pressure with decreased night-time blood pressure.47 Previous studies have shown that in patients with or without hypertension, a diminished nocturnal decline in blood pressure is a risk for cardiovascular mortality and is associated with elevated levels of inflammatory markers including PAI-1.48, 49 To determine the effect of mindfulness training on nocturnal dip in blood pressure, we will admit a subset of patients for overnight stays and will monitor their blood pressure via a 24-hour blood pressure monitor. Beginning at approximately 7 pm, blood pressure will be measured every 15 minutes. During sleeping hours, blood pressure will be measured every 30 minutes. Subjects will then go home with the blood pressure monitor and will return it to the GCRC that evening at approximately 7 pm.55 In 2005, Schneider et al published a study showing that transcendental meditation decreased levels of hypertension in African Americans with hypertension over a one year time period.9 We, therefore, hypothesize that the nocturnal blood pressure dip will be lower in the treatment group after mindfulness training than in the control group.