INTRODUCTION Dapagliflozin is a highly potent, selective, and reversible inhibitor of sodium-glucose cotransporter-2 (SGLT2), the major transporter responsible for renal glucose reabsorption.1 Dapagliflozin lowers plasma glucose by inhibiting the renal reabsorption of glucose and by promoting its urinary excretion in patients with type 2 diabetes mellitus (T2DM).