Up to now, there are no known anticipated adverse events associated with the use of lubricin, anyway the occurrence of side effect It must be considered that topical treatment with lubricin or hyaluronic acid could cause local irritation or allergic reactions. There ar contraindications to the use of lubricin or hyaluronic acid eye drops. All examinations and assessments that will be carried out durin invasive, are commonly used in the management of subjects with dry eye and pose no risk to the subjects. There are no known co lubricin or hyaluronic acid eye drops. . No data are available about the embryo and fetal toxicity, therefore the experimental treatment will not be allowed to pregnant women or nursing mothers and women of childbearing potential not using appropriate birth control methods.