November 2016 - December 17 Inclusion-period. A preliminary study has revealed 50 - 60 eligible patients per months in Helsingborg. With an attrition rate of 30-40% there will be around 35 patients to be randomized a month. To reach the empowered number and with lower inclusion rate during summer and vacations it will take 12-14 months to include all participants and the study period for each participant will be 2 years.