Sample size determination: Gluten consumption is toxic when consumed by people with CeD. Unlike a conventional trial testing an intervention to reverse disease, this trial relies on gluten toxicity to promote disease activity. The trial primarily evaluates the safety of gluten exposure in CeD in hookworm-infected Participants. The escalating gluten challenge proposed is unprecedented, and whilst liberal gluten consumption is consumed by many people with CeD either though ignorance of diagnosis or a conscious decision not to comply with medical advice, it is anticipated this challenge will adversely affect the unprotected placebo controls. Consistent with this concern, the control cohort has been kept small. The study will consist of 60 participants, with 10 in the control group, 40 in the low-dose hookworm group (L3-10) and 10 in the medium-dose hookworm group (L3-20).