Recipients will be screened upon presentation to the hospital. To establish enrollment, the wound will be examined and measured. A complete medical history and physical exam will be performed. Blood will be collected to test for blood bourne pathogens, including hepatitis and HIV. A pregnancy test will be done for females. Once the patient is enrolled, MSC's will be applied according to the dose and frequency determined by the Phase 1 trial. At various intervals, skin biopsies, wound measurements, questionnaires and possibly bone marrow aspirate may be performed (see below).