Adjustment based on day 8 count Platelets (x 109/l) ANC (x 109/l) Action > 75 and > 1.0 Proceed with day 8 dose > 75 and 0.5 - 1.0 Proceed with reduced dose 50 - 75 and ~ 0.5 Proceed with reduced dose < 50 and/or < 0.5 Omit dose When day 8 dose is reduced, the same reduced dose will be used for the following cycle.