- Subject has a mean pulse < 45 or > 90 bpm; mean systolic blood pressure < 90 or > 140 mmHg; mean diastolic blood pressure < 50 or > 90 mmHg (measurements taken in triplicate after subject has been resting in supine position for 5 minutes; pulse will be measured automatically) at screening or day -1. If the mean blood pressure exceeds the limits above, 1 additional triplicate can be taken.