The study is double blind. The Subjects and those who conduct the study are unaware of the state of the patient with regard to receiving CinnoRA® or Humira®. For this to happen, Subjects are blinded by using a masked prefilled syringe content biologically inert substance drug, Adalimumab (CinnoRA® or Humira®). The injection method, injection syringes and cartridges are totally the same in both groups. During the study, patients are completely unaware of the types of medications and groups of therapy.