3.122 Prior chemotherapy for advanced disease. Only one prior adjuvant therapy including CPT-11, or 5-fluorouracil-leucovorin, Capecitabine but not oxaliplatin is allowed if it has been >= 6 months since the last treatment. Patients enrolling in the Phase I portion of the trial may have received one advanced disease regimen that does not include either ALIMTA or oxaliplatin.