All SAE and AESI (serious and non serious), need to be reported to Roche within 24 hours. Categories of AESI have been identified for ACTEMRA (Tocilizumab): infections (including opportunistic infections), myocardial infarction/acute coronary syndrome, gastrointestinal perforations and related events, malignancies, anaphylaxis/hypersensitivity reactions, demyelinating disorders, stroke, bleeding events, hepatics events. The Investigators should use their clinical judgement to identify events falling in any of these AESI categories.