Statistical Analysis The normality of the distributions of the values of the biological markers will be tested with the Kolmogorov Smirnov test. Logistic regression models including the biological markers as explanatory variables will be used to identify their potential effect on clinical outcomes. In addition, receiver operating characteristic curves will be constructed, in order to assess the prognostic value of the biological markers with respect to clinical outcomes. Based on prior data, the investigators estimate that complete data from a minimum of 50 patients will be needed for study completion.