10. Adequate organ function as determined by: I.Absolute neutrophil count ≥ 1.5 × 109/L (1,500/mm3) II.Platelet count ≥ 75 × 109/L (75,000/mm3) III.Hemoglobin ≥ 9.0 g/dL IV.Prothrombin time-international normalized ratio and partial thromboplastin time ≤ 1.5 × ULN V.Calculated creatinine clearance* (CrCl) or 24 hour urine CrCl > 50 mL/minute VI.Total bilirubin ≤ 1.5 × ULN; for subjects with documented/suspected Gilbert's disease, bilirubin ≤ 3 × UL VII.AST and ALT ≤ 2.5 × ULN VIII.Serum electrolytes within normal limits