Intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors have being increasingly used in the treatment of neovascular age-related macular degeneration (AMD) in ophthalmic practice.1-4 The most commonly used VEGF inhibitors are bevacizumab (Avastin®, Genentech, San Francisco, California, USA), ranibizumab (Lucentis®, Genentech, San Francisco, California, USA) and aflibercept (Eylea®, Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA) among which aflibercept and ranibizumab were approved by the Food and Drug Administration (FDA) for this indication.