Two factors that likely affect the amount of weight gain with Depakote treatment are gene sequencing and gene expression. Although these analyses can be costly, DNA material, including RNA, can be archived from whole blood samples and stored for later analysis. This method allows cost to be controlled since analyses can be conducted on a sub-sample of the participants who displayed specific reactions to treatment during the study. For example, genomic studies can be conducted on participants who fall within the lower and upper quartiles of weight gain, or a sub-sample of participants from the placebo and treatment groups. This provides empirical tests of a priori stated hypothesis without the need to endure the costs of running genomic analyses on the entire sample of participants. In the present study, both gene sequencing and gene expression studies will be made possible by archiving blood samples, as outlined in the Methods section. These analyses will depend on the availability of funds and the development of specific testable hypotheses (e.g., weight gain in the Depakote group will be associated with the peroxisome proliferator-activated receptor-gamma gene).