Clinical Assessments: The symptom assessments will include the Brief Psychiatric Rating Scale (BPRS; Overall and Gorham, 1961); Scale for the Assessment of Negative Symptoms (SANS; Andreasen, 1982); and Clinical Global Impression Scale (CGI; Guy, 1976). i) BPRS: the four positive symptom items - conceptual disorganization, suspiciousness, hallucinatory behavior, and unusual thought content - will be used to measure positive psychotic symptoms. These four items have been have been used to assess positive symptoms in previous studies (Kane et al, 1988; Buchanan et al, 1998). The BPRS Anxiety/Depression Factor, consisting of the somatic concern, anxiety, guilt feelings, and depression items, will be used to assess dysphoria (Guy, 1976). The BPRS hostility and uncooperativeness items will be used to assess hostility. We are not including the suspiciousness item, which is traditionally part of the BPRS Hostility Factor (Guy, 1976), because we have included this item with the other positive symptom items. ii) SANS: the SANS total score, minus the global items, inappropriate affect, poverty of content of speech, and attention items, will be used to measure negative symptoms. The inappropriate affect, poverty of content of speech, and attention items are excluded as lacking construct validity and because factor analytic study results suggest that these items are not closely related to negative symptoms (Buchanan and Carpenter, 1994). iii) CGI: the CGI severity of illness item will be used to assess global changes.