- Taken any prescription medication (with the exception of hormonal birth control medications or hormone replacement therapy) within 14 days (or 5 elimination half-lives, whichever is longer) of admission to the unit (Day -2), or have taken any over the counter (OTC) medications, including topical medications, vitamins, herbal or dietary supplements/remedies (e.g., Saint John's Wort or Milk Thistle), within 14 days of admission, or planned concomitant medication while in the study (except for acetaminophen or naproxen, if needed for headache or pain).