Lung cancer is the leading cause of cancer-related mortality worldwide. A report published by the WHO in February 2014, estimated there were 1.83 million new cases and 1.59 million deaths worldwide in 2012. The American Lung Association reports 399,431 Americans living with lung cancer, with an estimated 221,200 new cases predicted to be diagnosed in 2015; of those cases 158,040 patients will die of their lung cancer which accounts for approximately 29% of all cancer deaths in the U.S. Similarly, lung cancer is the most frequent cancer in China and is among the 1.96 million estimated annual cancer related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancer in China, and approximately half of the patients present with advanced disease at the time of diagnosis.