Subjects will then have their medical history and use of medications reviewed, including the use of non-prescription and herbal remedies. Subjects will be given a complete physical examination by a physician, including vital signs (blood pressure, heart rate, breathing rate, temperature, height and weight) and an assessment of pubertal development by Tanner stage. Breast development will be assessed by visual inspection. Pubic hair will be assessed by visual inspection. Testicular volume will be measured by direct comparison to orchidometer beads. Tanner Staging will be assessed by a gender appropriate physician.