The investigators will provide the Exeter Clinical Research Facility (Exeter CRF) with a list of the sample numbers that have been identified as having the Individuals identified with the "polygenic lipodystrophy" genetic variants of interest, together with control individuals carrying the average number of risk alleles. The Exeter CRF Data Manager will then identify 50 individuals with the variants and 50 individuals matched for age, gender, diabetes status and BMI, who will be invited to a 5-hour visit to the Exeter CRF for data and sample collection. Interested participants will be contacted directly by a member of the study team who will be responsible for the recruitment process, providing more detailed verbal and written project-specific information.