The impact on cost savings for the hospital population will be studied from the healthcare-payer perspective. Therefore the official list price for acquisition, which equals the reimbursement price for hospitalized patients, at 01-07-2013 for the hospital will be used. In case of inappropriate therapy or late IV/PO switch there is an opportunity for cost saving. This will be subject to a sensitivity analysis. Besides direct cost savings there may be a possible long term cost-avoidance, but this is more difficult to calculate because side-effects of long term therapy are just popping up in research and cannot be monetized yet.