Our primary outcomes will be the most important outcomes for testing the hypothesis that SGLT-2 inhibitor dapagliflozin versus the SU gliclazide causes an improvement in renal hemodynamics. The large amount of secondary/exploratory endpoints potentially justifies the use of corrections for multiple tests. However, there is an increasing debate on whether this should be done, because of the increased risk of type 2 errors which could lead to prematurely discarding of potential useful observations. As recently pointed out, in a hypothesis-generating study - such as the current study - correction for multiple outcomes can be detrimental. A final decision will be made in the detailed Statistical Analysis Plan (SAP) prior to the conduction of the analysis.