4.4.2 Trial medication administration: Preparation and dosing of AAT-1 will be performed by an unblinded pharmacist. The medication will be diluted just prior to administration. The placebo solution will comprise human albumin that resembles the color and consistency of AAT-1 solution. The medication will be given 3-5 hours prior to surgery (skin incision). Administration rate of the drug will not exceed 0.04 ml per kg per minute (approximately 60-80 minutes). Vital signs including blood pressure, pulse rate and body temperature will be correspondingly monitored.