Statistical Assessment The Shapiro-Wilk test was used to determine whether the data were normally distributed. The Friedman test was used for four time points in two groups. In cases of significant differences among measurements, the Bonferroni-adjusted Wilcoxon signed-rank test was used as post hoc analysis. Additionally, the Bonferroni-adjusted Wilcoxon signed-rank test (paired observations) was used to compare the two groups in the same time points. All tests were performed using statistical software (SPSS Inc., version 19.0, Chicago, IL, USA). The median with min-max values were calculated for each parameter as the statistical unit. P < 0.05 was statistically significant.