Subjects must be willing to allow storage of sputum, Mtb isolate, whole blood (PAXgene blood , plasma, PBMC), and urine on baseline, month 1, month 2, and end of treatment visit, saliva on baseline and end of treatment visit for use in future studies (for example, host response, spoligotyping, and genetic tests). Serum and whole blood for DNA are collected on baseline visit only.