Losartan, the first angiotentsin II receptor blocker (ARB), is known to reduce blood pressure (BP). The LIFE study, Cardiovascular Morbidity and Mortality in the Losartan Intervention for Endpoint Reduction, showed that losartan prevented more cardiovascular morbidity and mortality than the ß receptor blocker atenolol. This effect was independent of its BP lowering effect. Left ventricular hypertrophy (LVH) is known to be a cardinal manifestation of BP and an independent risk factor for cardiovascular complications. In the patient subgroup of isolated systolic hypertension, losartan was found to reduce cardiovascular and all cause mortality and to reverse LVH.