Given the wide geographic distribution of patients with FH, we plan to provide a "hub and spoke" model specialized care. The hubs would be based in each province in centers recognized at the national level for their expertise in lipoprotein disorders and with advanced laboratory facilities (medical biochemistry, specialized assays, ultracentrifugation, genetic testing). Radiating from these centers will be clinics that treat patients with FH. We propose a three-tier registry (local, provincial and Canada-wide). The local database would be nominative, used solely by the clinic or center and contain the information obtained by the local investigators and used for clinical purposes. The provincial database will use encrypted numbers, without identifiers other than the provincial health insurance number, and will be used to generate province-specific health outcomes, resource utilization, health economics and comparative epidemiological/genetic/clinical features across provinces. The Canadian database would be anonymous and serve to generate country-wide statistics, public awareness and research collaborations.