Extra doses of fentanyl (50-100 µg) will be given if mean arterial blood pressure (MAP) increased more than 20% above the initial baseline level. Hypotension (MAP less than 60 mmHg) will be treated with 5-10 mg norepinephrine intravenously. All patients received 3-5 ml/kg/h of glucose solution 2.5% with sodium (70 mmol/l), chloride (45 mmol/l) and acetate (25 mmol/l) intravenously. Neuromuscular blockade will be monitored with a neuromuscular transmission analyzer (TOF-Watch™; Organon Technology B V., Boxel Netherlands). Additional doses of rocuronium were given at the discretion of the anaesthetist.