Current antiresorptive therapies include estrogen/ HRT (Hormone replacement therapy), bisphosphonates (BPP), selective estrogen receptor modulators (SERM) and denosumab (DMB). These agents mainly retard bone resorption in the trabecular bone, with minimal effects on cortical bone and are associated with only a 20-30% reduction in the risk of non-vertebral fractures. Moreover, they decrease bone formation and are not devoid of adverse effects. Some of these agents are also expensive and at times unavailable in some countries. All these limitations challenge the discovery of an ideal agent that can prevent bone resorption, increase bone formation and also reduce the risk of non-vertebral fractures.