Dose reduction schema First Reduction Second reduction Third reduction Carboplatin AUC 4.5 AUC 4.0 Off study Gemcitabine (standard arm) 750 mg/m2 (1000 mg/m2 x 75%) 500 mg/m2 (1000 mg/m2 x 50%) Off study Infusional Gemcitabine 75% of Phase II duration 50% of previous infusion duration Off study