This is a prospective, randomized study examining the ability of sitagliptin in expediting the wound healing process in the diabetic patient with a chronic foot wound. This is a single center study of 250 total subjects randomized into 2 arms. It is projected that this study will take 3 years to complete. The two arms will be 1) Januvia (sitagliptin) 100mg q day* and 2) placebo-control q day. Patients with Type II diabetes with a chronic foot ulcer will be enrolled into this study. Each subject will be randomized into one of the two arms and will participate in the study for a maximum of 16 weeks. At the end of 16 weeks subjects will be exited from the study. If at any time during the course of the study the wound heals, the subject will be exited from the study after a 2-week confirmatory visit.