7. For missing data exceeding a rate of 5 %, and with a statistical significant Little's test, indicating that the missing data is not a completely random sample of the total data, point estimates with 95 % CI will be calculated using a worst/best case scenario imputation on the missing values. If the imputation of a worst/best case scenario implies different conclusions, multiple imputations will be performed on the missing values assuming missingness at random[28]. Unadjusted and complete case analyses will also be presented.