Published results, as well as data from the investigators' collaborator, Dr. Edwards, have provided ample evidence that AMD is correlated with increased serum levels of Ba, C3d and fD; whereas elevated levels of Ba and C3d were documented in V62I subjects. The investigators expect to confirm and extend the findings in V62I subjects, and to identify a positive correlation between elevated levels of complement activation proteins and Y402H. Since smoke exposure has been shown to result in increased levels of alternative pathway (AP) activation [6], the investigators predict that some components (i.e., C3d or Ba) might be further elevated in the factor H risk population that smokes.