This active-comparator controlled mechanistic intervention study, using state-of-the-art methodology will expand our knowledge regarding the potential renoprotective effects of SGLT-2 inhibitors in human T2DM. The investigators hypothesize that SGLT-2 inhibitors may confer renoprotection by improving renal hemodynamics, and decreasing blood pressure and body weight, all important factors in the development of DKD. Ultimately, the investigators expect that this study will contribute to guiding clinicians in their decision-making process of individualizing therapies for T2DM patients at risk for, or suffering from, DKD.