3. HC participants will not currently meet DSM-5 criteria for moderate to severe substance use disorder (excluding nicotine), and in the past, will not meet DSM-5 criteria for moderate to severe substance use disorder for cannabis or alcohol in the past 5 years or ever for other illicit substances. HC will not meet current tolerance or withdrawal criteria for alcohol or sedative/hypnotics/anxiolytics. Urine toxicology positive for any illicit substance inconsistent with history given will also be exclusionary.