The primary objective of the Phase 1b study is to determine the dose-limiting toxicity (DLT) and maximal tolerated dose (MTD) of BP1001 and Dasatinib (Das) in patients with Philadelphia chromosome positive (Ph+) Chronic Myelogenous Leukemia (CML) in accelerated or blast phase. The primary objective of the Phase IIa study is to assess the efficacy of the combination of BP1001 and Das in patients with Ph+ CML.