From another aspect, for the treatment of chronic hepatitis B, the virologic and serologic responses may also not be durable [Liaw et al, 2005; Lok et al, 2004; Hadziyannis et al, 2003; Janssen et al, 2005]. Alternatively, previous studies suggested that the therapeutic efficacy might not be seen in the study period, and incremental response might occur during long-term follow-up as learned from previous experiences of using antiviral agents including interferon for the treatment of chronic hepatitis B [Saruc et al, 2003; Carreno et al, 2001]. Therefore it is also important to clarify the long-term outcome of treatment in this dually infected population.