- Patients who are with chemotherapeutic contraindications, such as white blood count ＜4.0×109/L, blood platelet count ＜80×109/L or severe anemia (Hb＜80 g/L); obvious liver dysfunction (increased transaminase or bilirubin ＞2.5 folds of normal level); un-manageable hypertension, diabetes, arrhythmia, repeated heart failure and chronic obstructive pulmonary diseases that could influence ventilation function; active stage of diseases infected by bacteria, fungi and virus; or patients who are in pregnancy and lactation periods.