Minocycline is a second-generation tetracycline used in humans, which effectively crosses the blood-brain barrier. Minocycline is commonly used by humans, because of its beneficial ant-imicrobial and anti-inflammatory properties. In addition, it has remarkable neuroprotective qualities in animal models of cerebral ischemia, traumatic brain injury, and Huntington's and Parkinson's disease. The neuroprotective effect of Minocycline is associated with marked inhibition of inducible NO synthase (iNOS), caspase 1 and caspase 3 expression, and p38 mitogen activated protein kinase (MAPK). Recently, it was found that Minocycline also inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice.