The rTMS was first used on small groups of patients suffering of chronic neuropathic pain secondary to trigeminal neuralgia or brachial plexus injury [56-58]. Lefaucheur et al [56] conducted a study in 18 patients with an average age of 54 years, presenting chronic neuropathic pain of one hand, resistant to drug treatment. The patients were randomized for three twenty minute sessions of rTMS, one with a low frequency (0.5 Hz) magnetic stimulation, other with high frequency (10 Hz) and the other with sham coil to evaluate the placebo effect. The level of pain before and after each session was evaluated by using the Visual Analog Scale (VAS). In this study it was determined that patients undergoing a 10-Hz rTMS perceived a more significant reduction of the pain compared with subjects who received a stimulation with 0.5 Hz rTMS or with those who only received placebo treatment. Subsequently, Lefaucheur et al [57] replicated these results in a group of 60 patients with neuropathic pain secondary to thalamic infarction, brachial plexus injury or trigeminal nerve injury, who underwent two sessions of high frequency rTMS separated by three weeks, concluding that 65% of the patients reported some improvement of their symptoms. The same author conducted a study that included 36 patients with neuropathic pain secondary to either brachial plexus or trigeminal nerve injuries. All of them received high frequency rTMS. The first one during two sessions and the latter received three sessions. As in the previous studies the level of pain was evaluated, before each session and one week after, using the VAS. The best response to pain was obtained between the second and fourth day after the initial treatment and this improvement was maintained for a period of seven days [59].