Sample size Sample size is calculated based on the proportion of gametocyte carriages before and after intervention in both arm.The assumption of gametocyte proportion rate used in the study is 20%, which is expected to decrease by 40% in arm 1 and decrease by 10% in the arm 2. Sample size calculation is performed by WinPepi software by assuming that the reduced proportion of gametocyte carriage of 40% in arm 1 and 10% in arm 2 (5% significance level, 80% power, and 1:1 sample size ratio). Required sample size would be 338subjects. After considering design effect of 1.5, we will recruit 507 subjects per arm that will be randomized from 1029 community participants