- On Days 1-7 and 15-21of every cycle, you will take the temozolomide by mouth 1 time a day. You should swallow the temozolomide capsules whole, one right after the other, without chewing them. If you vomit while taking temozolomide, you cannot take more capsules before the next scheduled dose. They should be taken on an empty stomach (at least 1 hour before and 2 hours after eating) with 1 cup (about 8 ounces) of water.