At the time of diagnosis and surgical evaluation, patients with resectable hepatocellular carcinoma will be asked to participate in this study.Patients will be registered after consent form is obtained. Patient is asked to donate tumor tissues, urine and blood samples.Tumorand normal specimens are collected at the time of surgery. After patient recovers from surgery (4-6 weeks) and fullfills the eligiblity, patient will receive gefitinib 250 mg p.o. daily for 6 months.