A. Conventional Cox-regression In the first analysis, a conventional observational analysis, the investigators will estimate hazard ratios of the outcomes using Cox-proportional hazards models and the actual prescriptions issued to the patients. Each patient's date of entry into the cohort will be the date they were first prescribed a smoking cessation therapy. The date of exit for each outcome will be the date on which they first have an event, or are censored due to end of follow-up or death or leaving the practice. The investigators will report these associations adjusted for basic confounders (age and gender), and results adjusted for all measured covariates described above.