Since the diagnosis of PDS is based upon a response to the therapeutic intervention and requires a trial of the treatment, and such replacement may provide a safe, efficacious treatment for PDS, we propose to assess the possible efficacy of B6 supplementation for NS in the form of oral pyridoxine treatment to evaluate the response and efficacy on the cessation or reduction of seizures. Dosing for pyridoxine is 30 - 50 mg/kg/day in a single daily dose.