- Pathological diagnosis for the resected tumor demonstrates transformation to higher grade (i.e. WHO grade III or IV) or gliomas. If a patient who received pre-surgical vaccines is diagnosed as high-grade glioma (HGG), the patient will be withdrawn from the study and considered for therapeutic options for HGG (trials for HGG or standard of care). The tumor tissue of such a case would be brought to the lab before the pathological diagnosis is made; and thus would be processed before the lab is informed of the final HGG diagnosis. Because HGG tissue may still reflect the vaccine effects, we will evaluate the tumor tissue to help us develop future approaches for HGG.