FØTOdatabasen is a national fetal medicine database. The database includes information on maternal characteristics: age, parity, BMI, ethnicity, smoking status, Diabetes status (from 2014), and on the pregnancy: mode of conception, result of first trimester risk assessment for chromosomal anomalies, biometric data, ICD10-codes for any prenatally diagnosed malformation. FØTOdatabasen receives this information automatically on a daily basis from all birth departments' prenatal database (Astraia), and links data regarding each pregnancy with postnatal outcome from the Danish Cytogenetic Registry, the National Patient Registry and the National Birth Registry. FØTOdatabasen includes >95% of all pregnancies in Denmark with due date from 1. January 2008 and onwards. The data completeness is high, with missing data <1% for pregnancy outcome, <1% for smoking status, and <3% for mode of conception.