We will study patients with severe burns, defined as 2nd or 3rd degree burn covering >40% of total body surface area (TBSA). We propose to study burned children from Shriners Burns Hospital. The Shriners census is such that approximately 50 children with severe burns are treated every year. We will study patients immediately prior to their third surgical procedure, approximately 12-15 days after injury. One half of the patients will be given fenofibrate (5 mg/kg/day) daily delivered through feeding tube from the time of consent following admission until 12-14 days post-burn. This length of time after injury will ensure that untreated patients will have a large accumulation of hepatic TG. Because the "control" group of patients will have elevated liver TGs, the "experimental" group will have their hepatic TGs lowered by fenofibrate. By studying the patients the day before the operations, it will be possible to remove the staples used in skin grafting without risk of loss of adhesion of the graph, thereby ensuring safety in the MRS. Femoral line inserted for the surgery can also be utilized, and all patient generally receive a full transfusion during surgeries, minimizing any study related blood loss. In addition to the liver, we will study the muscle in burn patients. Patients will be studied during brief fasted state. The will be fasted four hours prior to the study and then through out the study. Their TPN will be immediately reconnected following the study. The surgical team at the Shrine places 3Fr, 8 cm polyethylene catheters (Cook, Inc., Bloomington, IN) into the femoral vein and femoral artery under local anesthesia the day before surgery. Both femoral catheters will be used for blood sampling, while the femoral arterial catheter will also used for indocyanine green infusion for the determination of leg blood flow. Systemic concentration of indocyanine green will be measured from a central vein, as standard procedure has a multi-lumen subclavian line in all patients. Patency of all catheters is maintained by saline infusion.