1. Identify safer treatment and high efficacy in schizophrenia. The efficacy of ziprasidone in the treatment of schizophrenia has been demonstrated in both short-term and long-term controlled trials. Ziprasidone has been shown to be comparable to haloperidol, olanzapine and risperidone in alleviating overall psychopathology, improving associated depressive symptoms and cognitive function in schizophrenia. Ziprasidone was generally well tolerated in these trials, with a weight-neutral profile, with limited discontinuations related to adverse events.