However, there is a larger group of patients with elevated NP who have normal systolic function of the left ventricle but who have significant isolated diastolic dysfunction. These patients have asymptomatic left ventricular diastolic dysfunction (ALVDD) and are at heightened risk for heart failure and other cardiovascular events. The Investigators and others, have shown that cardiac inflammation, fibrosis and hypertrophy drive the pathophysiology. Importantly, there is currently no specific therapy for these patients, beyond conventional risk factor control.