- Target Lesions: All measurable lesions up to a maximum of 5 lesions per organ and 10 lesions in total representative of all involved organs should be identified as target lesions and be recorded and measured at baseline. Target lesions should be selected on the basis of their size (lesion with the longest diameter) and their suitability for accurate measurements (either by imaging techniques or clinically). A sum of the longest diameter (LD) for all target lesions will be calculated and reported as the baseline sum LD. The baseline sum LD is used as the reference by which to characterize the objective tumor response. If there are > 10 measurable lesions, those not selected as target lesions will be considered together with non-measurable disease as non-target lesions.