Platelets play an important role in cardiovascular disease both in the pathogenesis of atherosclerosis and in the development of acute thrombotic events. Their importance in coronary heart disease is indirectly confirmed by the benefit of antiplatelet agents in these disorders. Platelet adhesion, aggregation and activation are abnormal in patients with DM. Several factors were found to be associated with the abnormalities in platelet signaling in patients with DM, including increased levels of reactive oxygen species, altered calcium mobilization and increased protein tyrosine phosphorylation.