The Fluid-Translation of Research into Practice Study (TRIPS) is an international, single day, cross-sectional study planned for the second quarter of 2014, coordinated by the George Institute for Global Health, with the purpose of documenting prescribing practices for fluid resuscitation in intensive care units (ICUs) worldwide. This international cross-sectional study follows on from the publication of large-scale randomized controlled trials and meta-analyses of fluid resuscitation, which provide evidence of how fluid resuscitation may affect patient-centered outcomes.