For better controlling for those who might be lost during the study's period, the percentage of those participants LTFU will be calculated, whether or not they are equal for the intervention and the control group, and whether those LTFU have different baseline characteristics and prognosis than those who completed the study. Also, the investigator will make frequent contacts (at least twice) with all participants upon recruitment to insure not to lose any of them, and in case of lose any of them, the investigator will clarify the reasons for that. Later, in the analysis of this study, the investigator will apply an interim analysis and will use the worst-case scenario and will apply the intention to treat (ITT) analysis.