Percutaneous mitral valve repair is expanding treatment options for patients suffering from symptomatic mitral regurgitation (MR). The overall objective of the procedure is to reduce the degree of MR, which may lead to improvement in: 1) hemodynamics, an increase in systemic stroke volume and decrease in left atrial (LA) pressure; 2) left ventricular (LV) and LA volumes (reverse remodeling); and 3) efficiency in LV mechanics (decreased wall stress and improved fluid kinetics in the LV). The MitraClip System is the only percutaneous therapy available for high surgical risk patients with significant MR (Figure 1). Two-dimensional Echocardiography (2-D) data from the Endovascular valve edge-to-edge study (EVEREST trial) showed reverse modeling of LA and LV volumes in patients with primary MR after MitraClip implantation. In a separate study, patients with secondary MR who were non-respondent to cardiac resynchronization therapy (CRT) demonstrated improvement in LA and LV volumes post-MitraClip implantation [3]. Two smaller studies have also demonstrated the feasibility of using CMR to show improvement in LA and LV volumes post-MitraClip.