- Clinically significant abnormal EKG, or EKG with QT interval corrected for heart rate (QTc) using Fridericia's correction formula (QTcF) greater than 450 msec within 42 days of study entry. For Fridericia's correction refer to the calculator located on the Frontier Science & Technology Research Foundation, Inc. (FSTRF) website at www.fstrf.org.