This will determine whether 1 or 2 annual treatments with the triple drug regimen of DEC/Iver/Alb is equally or more effective than repeated annual treatments with DEC/Alb in inducing sustained clearance of Mf in LF infected subjects previously determined to have >100Mf/ml, indicative of a moderate to heavy infection. Subjects will be treated and monitored in several common areas near study subject residences.