2. Refractory or relapsed myeloma, defined as one or more of the following: 2.1. Treated with first-line therapy including at least 2 cycles of lenalidomide, bortezomib or thalidomide, and one or more of the following: 2.1.1. Less than PR to first-line therapy. 2.1.2. Relapse after 1st line therapy. 2.2. High-risk cytogenetics, defined by del(13q) by conventional cytogenetics, or by del(17p), t(4;14), t(14;16), t(14;20) or 1q+ by FISH. 2.3. Relapse after a prior ASCT. 2.4. Plasma cell leukemia. 2.5. Soft tissue plasmacytoma.