Myocardial infarction with non-obstructive coronary artery (MINCA) has recently received greater attention in the literature. The underlying patho-physiology responsible for MINCA revealed the presence of a typical myocardial infarct on cardiac magnetic resonance imaging in only 24% of patients, with myocarditis occurring in 33% and no significant abnormality in 26%. A rare cause of MINCA is Takotsubo cardiomyopathy, also called stress cardiomyopathy. Recently, coronary angiography using computerized tomographic angiography (CTA) has added a new dimension to the diagnostic armamentarium available to the clinician. Using advanced imaging techniques and low radiation, it is today possible to determine quite accurately coronary artery anatomy and thereby determine stenotic lesions in the coronary vasculature. Echocardiography can be easily performed by an experienced technician, the images stored digitally and evaluated subsequently by specialists. The availability of continuous perioperative monitoring of several hemodynamic indices as well as regular blood gas analysis, may enable determination of oxygen demand-supply mismatch.