Side effects seen during therapy of patients with Interferon and Ribavirin include flu-like symptoms mostly due to interferon, cytopenias and haemolysis induced by Ribavirin. Psychiatric changes due to interferon, occur in up to 50% and thyroid abnormalities requiring therapy occur in about 1 to 5% treated with interferon. Autoimmune disease and retinal haemorrhages have also been reported. In addition, combination therapy is associated with significant risks in patients with renal dysfunction, cardiac disease and haemolytic anaemias as treatment may be associated with anaemia. Patients who are depressed or suicidal should also be excluded (2).