Adverse events will be identified and recorded in Case Report Form by field team in collaboration with cadres and primary health center attendants. These subjects will be given symptomatic treatment at the village/sub-village level or at the local health center. Relationship between adverse event and study drug will be determined by Data Safety and Monitoring Board (Prof Rianto Setiabudy, dr Erni Juwita Nelwan and dr Hasan Basri) who will also decide how often the data will be sent to Jakarta. Specific Adverse Event are black urine, gastro intestinal disturbances, blue lips and breathless.