The duration of therapy (12 months) is based upon expert consensus and does not exceed that administered in other pivotal studies of adjuvant treatment in similar populations where treatment ranged from 12 to 60 months. In the absence of a reliable biomarker for minimal residual disease, empiric dosing for durations much shorter than the predicted median relapse free interval (median of 15 months) may increase the risk of treatment failure. The design does include predictive biomarkers which may allow further refinement of dosing once a phase III study of this design has been completed. Safety of continuous dosing of dabrafenib and trametinib for over a year as monotherapies has been established along with preliminary safety of combination dosing for a similar interval. Safety precautions will include clear guidelines for management of toxicity, including enhanced surveillance for adverse events of special interest along with instructions for dose modification. The inclusion/exclusion criteria will also serve to minimize participation of those at greatest risk for known or suspected toxicities of the combination therapy.