Currently, in the field of acute renal injury studies, progress has been made in the emergence of new biomarkers such as the tissue inhibitor metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding globulin-7 (IGFBP7), which are early markers of acute renal damage in (Kashani K., Al-Khafaji A., 2013, Bihorac A., Chawla L. S., 2014. In a study in adult patients (MeerschM.,SchmidtC., 2014), it was shown that the levels of TIMP-2 and IGFBP7 increased In the first 24-48 before the diagnosis of IR-associated renal damage.