Before the administration of the drug, at the end of infusion and after 30 minutes after infusion, the main parameters of the sublingual microcirculation will be monitored, using the the incident dark field imaging technique (IDF), including an assessment of glycocalyx, Near InfraRed (NIRS) parameters with the vascular occlusion test (VOT), vital signs and the dosage of any infusion of vasoactive drug.