There is an increasing large amount of evidences showing that rapid fluctuations in blood glucose and high glycemic variability may have an important role in the development of diabetes complications. Cardiovascular disease, endothelial dysfunction and oxidative stress are common complications among patients with type 2 diabetes and glycemic variability may be an important factor in their development. Previous studies have shown that vildagliptin, a dipeptidyl peptidase 4 inhibitor (DPP-4 inhibitor), could improve not only the mean blood glucose but also the 24-hour glucose fluctuation by restoring the physiological pattern of insulin and glucagon secretion. SGLT-2 inhibitors are novel anti-diabetic drugs and currently there are not published studies that evaluated their effects on glycemic variability calculated by the widely used methods like mean amplitude of glycemic excursion (MAGE), standard deviation of the mean glycemia (SD), coefficient of variation (CV) and interquartile range (IQR).