The DNA testing, referred to "genotyping" will be conducted by a combination of technologies designed to detect variations from single nucleotide level (including polymorphisms, insertions and deletions), to larger gene deletions, rearrangements, hybrid structures and copy number variations using established methods in the Developmental Pharmacology and Experimental Therapeutics Laboratory. As next-generation sequencing technology becomes established, existing technologies will be replaced by next-generation sequencing for its ability to assess the entire gene region rather than at individual locations.