- Neutrophils <1.0x10^9/L, platelets <50X10^9/L, creatinine greater than or equal to 1.5 times the upper limit of normal or estimated creatinine clearance <50mL/min/1.73m^2 (Cockroft-Gault formula), serum aspartate aminotransferase or alanine aminotransferase concentration >3x ULN or total bilirubin greater than or equal to 1.5x ULN