Screening Visit 1A: Subjects will be screened based on their medical history, symptom questionnaires (e.g. OSDI) and a full ophthalmic examination which will include baseline measures including visual acuity and biomicroscopic evaluations of the anterior segment (i.e. Tear Break Up Time (TBUT), corneal and conjunctival staining, lid wiper epitheliopathy, conjunctival redness and tear film evaluation).