- For potential candidates for this trial, the recommended acute GVHD prophylaxis is a tacrolimus, methotrexate and atorvastatin combination. However, any acute GVHD prophylaxis regimen at the discretion of treating physician (not involving in-vivo or ex-vivo T-cell depletion, CD34+ cell selection, or post-HCT cyclophosphamide) will be permitted.