Drop-outs: Patients who quite NOACs or are lost to follow-up are considered drop-outs. Those who (temporarily) quite NOACs will be followed until the total follow-up of 2 years will be completed. The events that occur in the period off-NOAC will not be included in the analyses. A clear description of the reason of NOAC arrest or interruption and possible alternative anticoagulant therapy is assessed.