The present proposal is in response to a request for applications for pilot studies to establish the methodological feasibility and strengthen the scientific rationale for proceeding to full-scale RCTs on the use of chiropractic or osteopathy to manage or treat musculoskeletal injuries and disorders. One of the stated goals of this request for applications is to refine the control strategy for studies of manipulative therapy. The proposed study will examine whether an amnestic agent, midazolam, can be used to blind subjects to their experimental group in a double-blind, pilot RCT. This proposal is similar to a study by Sloop et al who used diazepam to produce amnesia in a study of spinal manipulation for chronic neck pain. The present study will utilize an agent with more specific amnestic effects and will also address several methodological problems with their study. If successful, the methods employed in this pilot study may permit a high degree of blinding in full scale RCT's of spinal manipulation.