CONTROL (N=350) TREATMENT (N=350) GDP monitor GDP monitor NO Blood prime (withdrawal) NO Blood prime (withdrawal) Priming volume and nature according to local standards Priming volume and nature according to local standards Perfusion targeted on body surface area and °C Perfusion targeted on DO2 ≥ 280 mL/min/m2 Perfusion pressure according to local standards Perfusion pressure according to local standards Transfusion triggered by HCT according to local standards Transfusion triggered by venous oxygen saturation < 68% and/or oxygen extraction rate > 40% Postoperative care according to local standards Postoperative care according to local standards