4.4. DURATION OF THE STUDY 4.4.1. Study duration for study patients Each enrolled patient will remain in the study throughout the entire study duration, with a minimum follow-up of 1 year for each patient. A study patient's participation may be terminated early for reasonable cause, such as the investigator's medical decision. At any time, the patient has the right to withdraw consent without a negative impact on her/his medical treatment. However, the investigators are encouraged to ask for the patient's permission for further follow-up telephone contacts from those whose decision for discontinuation was based on the need for further outpatient visits.