- Congestive heart failure New York Heart Association (NYHA) class 3 or 4, or subjects with history of congestive heart failure NYHA class 3 or 4 in the past, or history of anthracycline or anthracenedione (mitoxantrone) treatment, unless a screening echocardiogram or multi‐gated acquisition scan performed within 3 months of the screening visit results in a left ventricular ejection fraction that is >= 45%