- Subjects with untreated brain or meningeal metastases are not eligible (computerized tomography [CT] scans are not required to rule this out unless there is a clinical suspicion of central nervous system [CNS] disease). Subjects with treated and radiologic or clinical evidence of stable brain metastases (confirmed by 2 scans at least 4 weeks apart), with no evidence of cavitation or hemorrhage in the brain lesion are eligible providing that they are asymptomatic and do not require corticosteroids.