In addition, it is not clear whether the children with NS are obtaining clinical benefit or are being harmed from AED treatment. Given the knowledge on the nature of the seizure types seen in NS, it is possible that NS will be difficult to manage with conventional AED approaches. In fact, certain antiepileptic medications may in some cases paradoxically exacerbate certain seizure conditions (18, 19, 20, 21, 22). Such exacerbation is particularly true in epileptic encephalopathies. For children with cryptogenic generalized epileptic disorders, the AED sodium valproate (valproic acid) has been found to be often effective, has fewer side effects than many other AEDs, and is considered the drug of choice (42). Valproic acid is currently listed as a recommended AED by WHO. The investigators therefore propose a simultaneous assessment of pyridoxine, valproic acid, as well as an AED that is currently being utilized in the community for children with NS (phenytoin) and compare them with response if any to a placebo controlled intervention group.