CTRG clinical report forms will be used to record data for this study. All patient clinical report forms will be faxed to the CTRG Office (+65 777-5545). A copy of each patients eligibility report form, randomization report form (for phase II), study schedule, consent forms, laboratory and radiological reports, and QoL assessment will be kept in the CTRG Office. All records will be kept for a period of 6 years following the date of study closure according to Singapore GCP guidelines