In stage IV melanoma patients, over 73% of patients who respond to BRAF inhibitors, will achieve a RECIST response by the time of the first scan (8 weeks), and the median time to best response is 12 weeks in the poorest prognosis patients. The progression free survival (PFS) for the combination is 9.4 months, and <5% of patients have progression as their best RECIST response. Therefore, 12 weeks was chosen for the period of neoadjuvant combination therapy to optimise tumour shrinkage, without compromising patient safety.