The main outcome to evaluate between both groups during this period will be number of relapses (Manic, Hypomanic or Depressive Episodes) during the 6-month treatment phase. Secondary outcomes will include the number of relapses during 6-month post-intervention follow-up (Manic, hypomanic and depressive episodes according to DSM-5 criteria). In addition differences in biological rhythms (BRIAN), differences in manic symptoms using the Young Mania Rating Scale (YMRS) and depressive symptoms using the Hamilton depression Rating Scale (HDRS) during the 6-month treatment phase and 6-month post-intervention follow-up. Additionally the quality of life (WHOQOL-BREF), functional Impairment (FAST) and treatment adherence (Morisky Green 8-item scale) will be assessed each follow-up assessment. Other outcomes include differences in healthcare resource consumption measured in number and duration of hospitalizations, outpatient and emergency room consultations related to their psychiatric disorder and pharmacological treatment changes (doses and agents prescribed) over the 12 month follow-up.