Sample size is estimated based on expected percentage indicator according to Fleisse. Other sample size estimates were estimated using standard method. Each sample must contain 26 -47 patients for mortality estimated between 30-40% and in case of statistically significant difference 20-30% when 5% level of significance and test power 70% in case of one sided test. Morbidity estimated to 60% and clinically significant difference 30-40% requires sample size of 19-32 subjects providing the same significance level and one sided test. Statistical evaluation of results will be included based on pair tests. Difference of individual variables between both groups will be evaluated using Student pair test or its non-parametric variant (Wilcoxon test). SOFA, APACHE II scores and life quality assessment results (SF-36) will be evaluated using Hotelling test as multi directional generalization of Student test.