Number of patients 65 patients will be included in each group (a 130 patients in total). The sample size calculation is based on a clinical relevant difference of 10 point in ATRS, a standard deviation (SD) of 16 and power of 0.90 (two sided). In a previous material, with a fully comparable population, we found a SD of 16 points at the 1 year post-examination. 54 patients is required in each group; due to the risk of drop out 65 patients will be included in each group.