<Time and process of getting informed consents> Principal investigator or sub-investigator fully explains the clinical study to candidate patients using informed consent form approved by the Institutional Review Board prior to the study procedure and obtains written informed consent from subjects on voluntary basis after confirming that patients duly understand the content of the clinical study. Principal investigator or sub-investigator who gives explanation to patients and study patients affix a name and seal or give a signature and enter the date on the informed consent form. If study collaborator gives supplementary explanation, the collaborator also affixes a name and seal or give a signature and enter the date.