Statistical power To estimate the statistical power with respect to the effect of the cohort investigated, we first evaluated the risk of disease and death in the total Swedish population of 70-year old men and women that lived in Sweden 2006 (n=72375). During 5 years of follow up, 8969 subjects died, 2695 individuals suffered a first myocardial infarction and 2855 suffered a stroke, according to national registers. If we assume a similar risk of CVD, stroke and death in our cohort there will be 620 deaths and 383 incident cases of CVD or stroke during 5 years of follow up. Thus, also under two-tailed hypothesis testing, the total number of outcomes will enable detection of numerically small associations, and small differences in associations. Concerning the evaluation of the intervention given among the HAI participants, compared to the rest of the Swedish population of 70 year old men and women, we assume that the intervention will reduce the future risk of the combined endpoint death, myocardial infarction and stroke by at least 15%. If we then assume a sample size of 3500 individuals (in each group) and a significance level of 0.05, we will have 96% power to detect a difference. Given that the control group will be much larger, the statistical power is likely to be adequate also for detecting smaller differences between the groups.