The participants were recruited from multiple communities covered the majority of Guangzhou city via the following measures: local advertisements, health talks, and referrals. The sample consisted of 68.0% women. At baseline, the mean age was 59 ± 6 years (women: 58 ± 5.7 years; men: 61 ± 7.0 years). 68% and 25% of them had education levels of secondary school and high school or above. 90% were married and 12% were smoker. Among women, 91% were menopausal. Mean BMI were 23 and 24 kg/m2 in women and men, respectively. Up to May 2017, 4540 participants attended baseline survey, 3400 and 2380 subjects completed the 2nd and 3rd visits. The whole cohort is planned to be followed at least 15 years.