Additionally, patients with inflammatory breast cancer will be treated with dense administration of epirubicin (100 mg/m2/2 weeks). We keep the same drug as for early breast cancer but we use a slightly more aggressive regimen with a higher dose-density. The feasibility of the administration of epirubicin 100 mg/m2 every two weeks with granulocyte-growth factor support has been shown in the neoadjuvant, metastatic and adjuvant settings with acceptable toxicity. This neoadjuvant epirubicin regimen may be completed by adjuvant chemotherapy, such as taxane-based regimens, since the sequential approach (anthracyclines and taxanes) has been suggested superior to anthracyclines regimen in LABC.