- Subject has a total area of atrophy of ≥ 2.5 mm2 (1.0 disc area [DA]) and ≤ 12.5 mm2 (5.0 DA) in the study eye, as determined by fundus autofluorescence (FAF), at the screening visit. If atrophy is multifocal, at least 1 area must be ≥ 1.25 mm2 (0.5 DA).