If 2 of the 6 subjects in Group 2 experience a Dose Limiting Toxicity (DLT), then Part 2 of the study will proceed with subjects only in Group 1. If 2 of the 6 subjects in Group 3 experience a Dose Limiting Toxicity (DLT), then Part 2 of the study will proceed with subjects randomized to either Group 1 or Group 2.