- Patient with advanced breast cancer with HER2 positive histologically confirmed. The criteria for positivity HER2 are: - IHC 3 + - IHQ2 + with FISH / CISH / SISH positive for HER2 amplification (*) - FISH / CISH / SISH positive for HER2 amplification (*) (*) Defined as the ratio of copies of HER-2/neu and copies of centromere of chromosome 17 (CEP17)> 2.2, or a number of copies of HER-2/neu> 6, as per local laboratory criteria.