Based on previous studies, terbinafine may be associated with cure rates of approximately 50% (when given for a full three month course).18 The success rate of the FOX laser group has not been thoroughly investigated. Table 2 provides the power to detect various true differences between the control and laser groups where the control group is assumed to have a success rate between 40% and 60%. A sample size of 80 subjects in a 1:1 randomization to the control and laser arm will provide a power of 80% to reject the null hypothesis if the laser arm true cure rate in the control arm is 79% and the control arm is achieves a cure rate of 50%. If the success rate in the control group is as high as 60%, a difference of 26% between the groups will be detectable with 80%. If the true difference is 34% or greater, it will be detected with at least 90% power. For a total sample size of 100, a true difference of at least 31% will be detectable with at least 90% power, a reduction of only 3%. Similarly, for a total sample size of 60, the difference must be at least 39% to be detected with at least 90% power, an increase of 4%.