We propose a trial to evaluate whether in-hospital glycemic control, as measured by mean daily glucose concentration and frequency of hypoglycemic events, is different between treatment with metformin and sitagliptin combination and treatment with glargine insulin once daily and rapid-acting insulin analog with meals in patients with type 2 diabetes. Hyperglycemia is associated with increased mortality, prolonged hospitalization and increased complications such as infection (1). Consensus guidelines recommend long-acting basal insulin and meal-time bolus insulin therapy for inpatient blood glucose management. These basal bolus regimens are labor intensive, require multiple injections each day, and can cause hypoglycemia. A study at our institution of patients admitted to the hospital and treated with our basal bolus insulin protocol found the incidence of hypoglycemia (blood glucose less than 70 mg/dl) to be 20% of all patient stays (2). A strategy for inpatient blood glucose management with less risk of hypoglycemia is needed.