The hospital pharmacist will manufacture both active misoprostol ground up as a whitish powder in capsules (500-μg per capsule), as well as an inactive ingredient with an identical appearance (lactose) in capsules as placebo. The hospital pharmacist will prepare numbered, opaque, sealed envelopes. The envelopes will be numbered according to a randomisation list. The hospital pharmacy will then insert the prepared capsules into the envelopes. Each envelope will contain two capsules. Half of the envelopes will contain two capsules with 500-μg misoprostol each, while the other half will contain two placebo capsules.