The "EndoBarrier" Gastrointestinal Liner System is an endoscopically-delivered device that offers an alternative to gastric bypass surgery. The device shields the duodenum and upper jejunum from contact with chyme, thereby mimicking the foregut bypass effect of a RYGB procedure without altering the subject's anatomy. Pancreatic and biliary secretions pass along the outside of the device and then mix with chyme in the upper jejunum. Based on animal experiments and clinical observations, the EndoBarrier device may provide a useful non-surgical intervention for treating T2DM, with an added benefit of weight loss. To date, over 13 studies enrolling over 500 subjects were performed with the EndoBarrier device. In one study, at 12 months 23/32 uncontrolled T2DM subjects (71.9%), were able to achieve an HbA1c value less than or equal to 7.0%.