This research study is a cross-randomized, placebo-controlled trial to evaluate an algorithm-based pharmacotherapy approach to treating tobacco use ('Algorithm') and the efficacy of a high intensity behavioral treatment in comparison to the standard of care. The Algorithm is designed to assist clinicians in identifying the appropriate pharmacotherapy and behavioral interventions to treat tobacco use and to provide additional medications to individuals who do not decrease tobacco use following two weeks of pre-quit pharmacotherapy ('Non-Responders'). The population group is recruited from patients being seen at the Duke Smoking Cessation Program. Outcomes of abstinence variables will be analyzed using general regression models using an ANOVA-based design; randomization status to both pharmacotherapy and behavioral groups will be denoted using a proxy variable to test primary study effects. An alpha criterion of 0.05 (two-tailed) will be used in all comparisons. Risk for the study is low as all pharmacotherapies being evaluated are FDA-approved for tobacco use treatment.