By 2020, 20% of the UK population will be over 65 y. Muscle mass is a strong predictor of healthy ageing and longevity. Basal limb blood flow decreases with advancing age; reduced limb perfusion may contribute to sarcopenia, the undesirable loss of muscle mass that accompanies advancing age. The investigators previous work has shown that there are deficits in the mechanisms of muscle protein synthesis in older people, but why these exist and how they may be countered is still unknown. After normal feeding, increased amino acid availability (stimulating muscle protein synthesis) and insulin availability (inhibiting muscle protein breakdown) do have good effects in the muscle of older people but not to the same extent as in the young; the investigators call this "anabolic resistance". The investigators have recently shown that leg blood flow in elderly people is lower than in the young at rest in the basal state and also at rest up to 2.5 hours after food and or food + exercise. The matching of blood flow and metabolism is advantageous for skeletal muscle, in marrying demands for oxygen and nutrients to their delivery; the reduced limb perfusion in the older people may contribute to an inability to maintain muscle mass with ageing. The investigators have recently shown that resistance training markedly improves leg blood flow responses in elderly persons. They believe a major benefit of resistance exercise is to increase endothelium dependent vasodilation in response to feeding and moderate exercise, but this needs to be proved. It is becoming recognised that it is not only "bulk" limb blood flow that may be important in muscle nutrient uptake but that so called 'nutritive' blood flow is an important determinant. Recent work suggests that bulk limb flow is not only partitioned between skin, bone and muscle but even within muscle is partitioned between 'nutritive' and 'non-nutritive'. The nutritive route has intimate contact with muscle cells while the non-nutritive route acts as a vascular shunt and is thought to be, at least in part, via vessels that nourish fat and connective tissue cells. Nutritive flow may be the component of flow which is most susceptible to dysfunction5 (e.g. with type 2 diabetes and obesity) but may also be the most susceptible to improvement by accustomed exercise and possibly nutraceutical treatment.