In gastric cancer patients, oxaliplatin has shown a more favorable toxicity profile than cisplatin . A combination chemotherapy of 5-FU with oxaliplatin, mainly FOLFOX regimens, has been investigated in numerous phase II studies, using different doses and schedules, and has shown considerable antitumor activity. Insofar as toxicity is concerned, significant toxicities, including myelo-suppression and peripheral neuropathy, are a major issue for elderly patients. When compared to standard FOLFOX schedules, both weekly and biweekly reduced-dose combinations of oxaliplatin/5- FU without 5-FU bolus showed a more favorable toxicity profile with lower rates of peripheral neuropathy and myelosuppression.