Subjects will receive a comprehensive eye examination as part of this study. This examination will include visual inspection by a trained ophthalmologist, assessment of visual acuity, SD-OCT, visual fields, and fluorescein angiography. The subjects and their physicians will be made aware of any identified abnormalities. The potential risk to subjects is modest. All of the planned tests are identical to those test routinely performed for purposes of diagnosing AMD or other diseases of the eye. Such studies are performed routinely in out-patient settings by ophthalmologists. In addition, information obtained from this study may provide an important link to understanding the pathogenesis of AMD, and its link with complement factor H haplotypes and smoking. Any relationship between the three could potentially lead to future therapies for AMD.