Government. This initiative will allow the development of clinical practice guidelines, to determine resource allocation according to need, the identification of rare (orphan disease) lipoprotein disorders requiring specific techniques, such as extracorporeal LDL filtration for homozygous FH. The initiative will allow the framework to set-up collaborative research under the peer-review system (HSFC, CIHR). Health outcomes and health economic studies will allow resource allocation and quality control. Finally centralized genetic testing would provide molecular diagnostics in a cost-effective manner, when required. This initiative will dovetail with the CIHR C-CHANGE initiative concerning the harmonization of cardiovascular preventive guidelines in Canada. To data, we are the only country with harmonized CVD prevention guidelines.