Clinicians. The registry will provide the local (i.e. clinic or hospital) framework to diagnose patients according to accepted international criteria for FH, to follow the subjects in time and to perform cascade screening (first, second and third-degree relatives), a cost-effective strategy to screen potentially affected subjects. The registry will also link clinicians into a network of specialized clinics that favor collaborative investigator-initiated research and participation in multi-center studies. The availability of biobanking will allow the storage of plasma/serum and DNA for future research.