Similarly, in a randomized 7 day four-arm trial involving 41 patients with erosive GERD, the rate of healing for patients using high potency sucralfate was 80%. The 7 day healing rate for acid therapy groups were considerably lower: omeprazole (20mg bid) was 30% and for ranitidine (150mg bid) and antacid groups healing was 0%. Apparently the topical coating of high potency sucralfate affects a mucosa-centric mechanism for healing that appears indifferent to gastric pH or acid exposure. Comparing the 7 day healing rate of high potency sucralfate to that of omeprazole there was a 2.67 or 367% improvement similar to that seen when high potency sucralfate is compared to placebo where there was a 2.34 fold or 334% improvement.