Sepsis is a clinical entity that complicates infections [1]. Without early recognition and timely management, it can rapidly progress to severe sepsis, septic shock, and culminate in multiple organ dysfunction syndrome. The incidence of severe sepsis is between 300 to 1000 cases per 100,000 persons [2] and is projected to increase annually due to an aging population, increasing burden of chronic disease, and greater use of invasive procedures, chemotherapy, and immunosuppressive agents [3]. Severe sepsis is the leading cause of mortality in critically ill patients, with healthcare costs exceeding $16 billion annually [4]. Despite evolving clinical guidelines for sepsis [5-7], and intense research, only a modest reduction in case fatality rates has been documented over the last two decades [8]. Aside from early administration of antibiotics, there is no effective stand-alone or adjuvant pharmacological intervention to improve survival in patients with severe sepsis.