Participants Children (5-16 years of age) with suspected acute uncomplicated appendicitis will be enrolled from up to 16 hospitals across Europe and North America. All centers are specialist Pediatric Surgery Referral Centers with trained Specialist Pediatric Surgeons and Pediatric Surgery Training Programs. All children with suspected acute non-perforated appendicitis will be assessed by the on-call surgeon who will determine eligibility for the study. This will be based on a clinical and/or ultrasound diagnosis of acute non-perforated appendicitis. The patient and child will be informed of the trial and invited to participate.