You will receive up to 8 cycles of EPOCH in combination with ofatumumab or rituximab (EPOCH-O/R) with 2 doses of ofatumumab or rituximab each cycle for the first 4 cycles, except for Cycle 1, where you will receive 1 extra dose of ofatumumab to help prevent side effects. You may receive rituximab instead of ofatumumab if your insurance provider does not cover the cost of ofatumumab.