Currently, treatment for HCV still has a significant non-responder rate and is associated with side effects which limits many individuals from receiving treatment. Already molecular profiling by DNA microarrays has identified potential genetic targets which may have a role in the pathogenesis of HCV-associated hepatitis and more importantly possible targets which have a role in response to Interferon treatment. The work proposed here hopes to build on this body of knowledge and may lead to improved treatment modalities for HCV.