All adverse effects will be graded by the attending doctors according to Common Terminology Criteria for Adverse Events version 4•0. The investigators have initially selected mucositis, hypothyroidism, hand-foot syndrome, hypertension, anaemia, and thrombocytopenia for analysis on the basis of clinical relevance and grading objectiveness, together with grade 3-4 adverse events. The investigators will also record adverse toxic events leading to dose reductions and the date on which they occurred.