There is currently no universal systematic screening of newborns for cCMV and while symptomatic infants may be tested for CMV due to clinical suspicion, asymptomatic infants present a greater challenge to early identification. Screening techniques are available and these include urine or saliva cultures with and without PCR, as well as blood PCR that can be run on dried blood samples (i.e. blood obtained as part of statewide newborn screening exams)2. Recent studies have shown that CMV PCR assays of liquid and dried saliva samples have a high sensitivity and specificity as compared to saliva cultures5. Although these tests are available, they are not routinely used for neonatal universal screening either before or after failed hearing screens even though it is known that detecting hearing loss early leads to earlier intervention and therefore better long term hearing and developmental outcomes, especially when the infants are treated with antiviral therapy such as ganciclovir or valgancyclovir2,6.