2. Systemic oxidative stress (time 0, weeks 16, 32): we will measure 4 serum markers of oxidative stress; protein carbonyls (a product of protein oxidation), TBARS (a measurement of lipid peroxidation), TRAP (a measure of total antioxidant activity), and isoprostanes (formed from the peroxidation of arachidonic acid in lipoproteins and membranes). Blood samples will be drawn in the fasted state both at initial screening and after ALA treatment. Protein carbonyls, TBARS, and TRAP will be performed at UC Davis Clinical Laboratories employing standard techniques. Serum 8-isoprostane-F2α will be measured by KRONOS Science laboratory, Phoenix Arizona. We will also measure urine markers of oxidative stress before and after CRLA treatment. These will include 8-isoprostane-F2α, and 8-hydroxy guanosine (a marker of oxidized DNA). These urine assays will be performed KRONOS Science laboratory, Phoenix Arizona and Dr Jack Roberts, Vanderbilt University.