The rate of mortality in the DCCT cohort has been low. The number of events has been too small to provide a definitive assessment of the possible effects of the initial intensive versus conventional therapy during DCCT on risk of mortality, or to assess the association of other complications, principally nephropathy, on risk of mortality. However, projections over the next 10 years suggest that an adequate number of deaths are expected to allow an assessment of the effects of previous DCCT therapy, the history of glycemia and emergence of other complications on the risk of mortality.