All the participants will be interviewed at baseline and follow up for 4 years. Data collection at baseline will be performed through face-to-face interviews by trained interviewers (neurologists from participating hospitals) with a standardized protocol. Baseline data include demographics, medical history, cardiovascular risk factors, dietary habits, physical activity, lifestyle, medication use, electrocardiogram, vascular imaging tests and Montreal Cognitive Assessment (MoCA). Blood and urine samples will also be collected at baseline to test genetic and metabolomic markers. Cardio-/cerebrovascular events, death and medicine use will be collected each year after enrollment. A further face-to-face interview will be performed after 4 years to collect plaque progression in intracranial and carotidal arteries using high-resolution magnetic resonance imaging (HR-MRI), and cognitive impairment using MoCA.