All procedures related to the FH registry will follow uniform standard operation procedures (SOP). The various steps associated with the inclusion of patients within the FH Registry will be the following: subject with high LDL-C, secondary causes ruled out, FH Criteria satisfied, consent form signed, clinical evaluation, baseline lipid profile, demographic info, family history, longitudinal follow-up (annual data capture). If a patient has a family history of FH, then we will start cascade screening. If the FH criteria are not satisfied at the beginning of the study then the patient will be asked to enter in the SMASH registry for other severe disorders of the lipid metabolism.