STATISTICAL ANALYSIS The results obtained from this study will be reported as a difference between the baseline and 6 months later following a single daily oral dose of 20 mg isosorbide mononitrate. The difference between the 2 groups will also be inferred at the end of 6 months. The changes in skeletal parameters (serum P1NP and CTX) and microcirculation will be compared between the 2 groups using t-tests to determine post hoc differences. A p-value of < 0.05 will be considered significant. All analyses will be conducted using the Statistical Package for Social Sciences (SPSS Inc., Chicago, Illinois, USA).