Dimethyl fumarate showed robust effect in suppressing the appearance of new CE, T2 hyperintense and T1 hypointense lesions along with their volumes. In a recent study, dimethyl fumarate also exerted potential for cytoprotection and remyelination, as evidenced by changes in magnetization transfer ratio. However, the dimethyl fumarate effect on non-conventional MRI metrics, such as diffusion-tensor imaging (DTI) has not been explored.