Many drugs have been found to be substrates for CYP2C9, including fluoxetine, losartan, phenytoin, tolbutamide, torsemide, warfarin, and numerous NSAIDs. CYP2C9 activity is inducible by rifampicin and possibly also by carbamazepine, ethanol and phenobarbitone. Several drugs have been reported to inhibit CYP2C9 activity in vivo or in vitro, for example: fluconazole, amiodarone, trimethoprim, fluvastatin, cimetidine and chloramphenicol.