Analysis will be undertaken by the biochemistry laboratory of the Royal Devon and Exeter Hospital. HbA1c, lipid, renal and liver profile will be sent for immediate processing and results copied to participants clinicians (with participants consent). Other analysis will be performed batched samples at the end of the study, with samples stored at -80oc prior to analysis. Blood samples for DNA extraction will be processed and stored by the Royal Devon & Exeter National Health Service Foundation Trust Molecular Genetics Laboratory.