5. Any clinically significant abnormal findings in vital signs at screening and first admission to the study unit, as judged by the PI. Abnormal vital signs, after 10 minutes supine rest, defined as any of the following: − Systolic BP (SBP) < 90 mmHg or > 140 mmHg − Diastolic BP (DBP) < 50 mmHg or > 90 mmHg − Heart rate < 45 or > 90 beats per minute.