This study is a randomized double-blind placebo control clinical trial conducted on two groups for 4 months. Patients receive oral nanocurcumin (80 mg / day) as compared with placebo group. After sampling both groups and separating plasma, peripheral blood mononuclear cells isolated by using ficoll and fresh and cultured in the presence of PHA. PBMC is used to measure the levels of miRNA-326, IL-17 and RORγt expression. the frequency of Th17 cells in peripheral blood will be examined by flowcytometry. To check the amount of the cytokine IL-17 in cultured cells supernatant is used ELISA technique.