CRP is a major marker of inflammation. Its production by the liver is stimulated by a network of adipocytokines including IL-6 and TNF- α.33, 35, 36 Type 2 diabetes has been shown to be preceded by a state of sub-clinical inflammation.35 Additionally, The European Prospective Investigation into Cancer and Nutrition (EPIC) Potsdam Study showed that increased levels of IL-6 independently predicted the risk of type 2 diabetes, and that a combined elevation of IL-6 and TNF-α was also associated with increased risk.35 Weight loss has been shown to induce a significant decrease in CRP and IL-6 and is associated with an improvement in insulin sensitivity.34 As well, a one-year multidisciplinary weight reduction program showed a decrease in IL-6 as well as TNF-α.37 MEAL thus proposes that mindfulness-associated weight reduction will be associated with a decrease in IL-6, TNF- α and high sensitive CRP, which will further be associated with improved insulin sensitivity as estimated by fasting insulin and fasting glucose.