Transition from one group to the next will be determined by review of available safety data by a Safety Monitoring Board (SMB) which will occur approximately one month post surgery of the last subject in the group. The study data will be collected for 6 months post stem cell transplantation of each study subject. However, all subjects will be followed clinically until death and all SAEs and post-study data will be collected and reported. Autopsy will be strongly encouraged for evaluation of pathology and presence of transplanted cells.