Biobanking will be performed at individual sites, when available. Plasma/serum, DNA, tissues (e.g. skin biopsies) will be potentially included. The consent form will have a specific section dealing with DNA banking and the possibility that the DNA may be sent to a central laboratory for analysis. The informed consent will also stipulate that plasma/serum and DNA samples may be analyzed by academic collaborators outside of Canada and by industry (pharmaceutical and/or biotechnology).