Fifty thousand persons are estimated to be infected with HIV in the United States each year, of whom one-quarter were youth between the ages of 13 and 24 years in 2010. Young gay and bisexual men accounted for 72% of all new HIV infections in the same year, with the majority of those being black youth. Despite elevated risk for HIV infection, it is estimated that only 6-16% of youth/young adults living with HIV (YLWH) are virally suppressed.Sufficient and sustained adherence to antiretroviral therapy (ART) reduces excess morbidity and mortality among people living with HIV (PLWH) and lowers the probability of forward transmission to sexual partners. Advancing targeted and innovative ART adherence interventions for YLWH is an urgent priority.