Evalution of annexin A1 Protein Expression The distributions of ANXA1 expression in four categories (0-25%, 26-50%, 51-75% and 76-100%) with nuclear translocation were firstly showed by clinicopathological parameters of the oral ED and SCCs and the correlations between mean levels of expression and these clinicopathological parameters were further examined using ANOVA. The Kaplan-Meier product-limit method was used to assess the prognostic significance of the ANXA1 nuclear staining in cancer cells as well as other clinicopathological parameters. Comparison of cumulative survival between groups was performed using the log-rank test with the Statistica program (StatSoft Inc., USA). Multivariable analyses were performed with Cox regression model to assess additional prognostic values of the different variables using SAS 8.0 (SAS Institute Inc., USA). A P-value of less than 0.05 was considered as statistically significant.