Anaesthesia and Surgery The surgical and anaesthetic techniques would be determined by physicians responsible for the patient and according to established hospital routines and practices. Patient records would be used for the determination of adverse events according to a standardized protocol. Patient characteristics, pre-operative risk factors, laboratory data and follow-up data would be obtained from medical records. Prophylaxis against deep vein thrombosis, surgical infections and fluid and electrolyte balance would also follow hospital practice. All included patients would be admitted to the post-anaesthesia care unit (PACU) overnight, and longer if deemed necessary by the attending Anaesthesiologist. Patients would be continuously haemodynamically monitored and anaesthesia records would be maintained for independent assessment by a blinded reviewer. Hs-TnT would be repeated in all patients at 24, 48 and 72 h postoperatively. Plasma NT-pro BNP would be re-assessed at 24 h. A 12-lead EKG would be recorded in all patients with elevated high-sensitivity TnT (hs-TnT) at the time of first occurrence and 48 h later. Platelet function tests, microparticles as well as coagulation tests would be performed periodically in the perioperative period. Further laboratory tests would be performed as needed at the discretion of the attending physician.