Based on data observed within the clinic from which cases are to be recruited, the success rate for Standard of Care patients is estimated to about 75%. A sample size of 200 subjects in a 2:1:1 randomization to the SoC, STP and IWL and groups respectively will provide a power of over 95% to reject the null hypothesis if the true difference between SoC and either experimental arm is 25% or greater (eg: 37.5% compared to 62.5%).