Pyrexia Sub-Study Combined therapy with dabrafenib and trametinib is associated with pyrexia in over two-thirds of patients. There are no identifiable clinical correlates of pyrexia and the mechanism remains unknown. Management involves the use of corticosteroids in 25% of cases. Further investigations of this drug-associated pyrexia are urgently required, particularly for facilitating the use of these drugs in the adjuvant setting. The context of this single institution study with its close and uniform patient monitoring provides an ideal opportunity to study drug-induced pyrexia, its mechanisms, prevention and management, and correlation of pyrexia with parent drug and metabolite plasma levels compared with those who do not develop pyrexia.