Empagliflozin is a selective SGLT-2 inhibitor, recently approved by the U.S. FDA for use in patients with T2DM. Empagliflozin in patients with type 2 diabetes provided sustained glycemic control and weight loss over 90 weeks and was generally well tolerated (1). Another study demonstrated that Empagliflozin in patients with T2DM resulted in reductions in HbA1c and fasting plasma glucose (FPG), and reductions in body weight compared with placebo. Empagliflozin was well tolerated with a favorable safety profile (2). Some congeners of this class of molecules have been seen to reduce liver fat content in rat models. However, the effect of this drug on liver fat content in humans has not been evaluated.