In a 42 yo head and neck patient treated simultaneously with paclitaxel, carboplatin and radiation (201Gy), high potency sucralfate (HPS - ProThelial) prevented mucositis, allowing continuance of standard oral diet. The percutaneous gastric-tube surgically placed in anticipation of Grade 3-4 mucositis was never used by the patient. While on ProThelial, the patient never developed mucositis. Noncompliant discontinuation of HPS by patient midway through chemo-radiation led to the emergence oral and alimentary mucositis with oral erythema, nausea and diarrhea. Two days following resumption of HPS, both oral and alimentary mucositis disappeared. Throughout treatment with ProThelial a normal oral diet was maintained and no analgesia was required for mucositis. Patient reported no adverse events while on HPS for 6 weeks.