This protocol is the first proof of concept study to evaluate the possible repurposing of Amlexanox for the treatment of type 2 diabetes and obesity. At the same time, we hope to test the hypothesis that IKKe and TBK1 may be important players in maintaining a positive energy balance, and also in supporting insulin resistance, during prolonged over-nutrition. Finally, these studies will also provide valuable insight into the validity of these two protein kinases as drug targets for the future development of new chemical entities useful in the treatment of type 2 diabetes. Therefore our specific aims are