Surgeons at the Melanoma Institute Australia perform approximately 120 lymphadenectomies each year for patients with palpable lymphadenopathy. The sample size of 35 patients is achievable within the anticipated 12 to 18 month recruitment phase. Neoadjuvant therapy with combined dabrafenib + trametinib for these high-risk melanoma patients with bulky regional stage IIIB-C lymphadenopathy may result in improved rates and duration of local control with reduced surgical morbidity.