In Part II one additional acadesine dose will be administered for each successive new cohort enrolled. The decision to add an additional dose in a separate cohort of patients will be based on assessment of safety, including any DLTs, PKM of exposure to ZMP, and pharmacodynamic response data, where available, by the DMB. Blood samples for PK analysis in Part II of the study will be taken pre-dose and at 0, 30, 60 minutes, 2, 6, 20, 72, 96, and 168 hours post-dose on the first and last day of dosing and also at pre-dose and 0 minutes post-dose for any interim doses. Samples will also be taken 14 and 21 days after completion of the last dose for each patient.