The purpose of this study is to determine if Laser Interstitial Thermal Therapy (LITT) is safe in newly diagnosed glioblastoma (GBM) patients unable to undergo broader surgical resection. LITT, and specifically the NeuroBlate® System (NBS), represents a unique tool that may permit the development of much needed novel treatment algorithms for those GBM patients inappropriate for the conventional surgery followed by chemotherapy and radiation. The primary objective is to assess the safety of combination LITT and short-course radiation therapy (SCRT) for patients with newly diagnosed GBM not amenable to standard of care (SOC) therapy.