This randomized, double-blind, placebo-controlled study will be conducted in 240 women over a 52-week period. Women will be randomized to receive either placebo or DHEA (50 mg/day) for a 52-week period. It is anticipated that the study will require a 6-month recruitment period. The study duration will be approximately 56 weeks, with a 4-week screening period and treatment period of 52 weeks. The study will be conducted over approximately 13 months. This is a single-centre study and will be conducted at the Alfred Hospital.