GROUP B: Patients receive filgrastim SC on days 1-8 and receive bortezomib IV over 3-5 seconds on days 4 and day 7, before administration of filgrastim. Patients undergo apheresis on days 5-8. Within 2 months after mobilization, patients undergo autologous hematopoietic stem cell transplantation after receiving high dose chemotherapy and PBSC infusion as is the standard of care.