Prostate cancer remains the leading cancer diagnosed in men in the USA. It is estimated that 232,090 new cases will be diagnosed in 2003, which account for about 30% of all cancer cases diagnosed in men.(1) Prostate cancer is still the second leading cause of cancer death in men (after lung cancer) in the US with estimated 28,900 men dying of prostate cancer in 2003. Although 79% of men will present with early stage disease (i.e., local or regional) at the time of diagnosis, a substantial number of men will present with metastatic disease. (2) Unfortunately many of the patients who present with local disease and are treated with local therapy will eventually experience disease recurrence. Initial treatment for patients with prostate cancer in advanced stages has been through androgen deprivation. Approximately 85% of men will have an objective response to hormonal therapy initially but eventually these patients will develop progressive and eventually fatal disease. Treatment options for patients with HRPC include systemic cytotoxic chemotherapy and /or palliation of symptoms (especially pain) (3). Single agent and combination chemotherapy regimens have been associated objective response rates ranging from 40-70% in patients with HRPC (4). No survival advantage has been shown with any treatment in phase III studies. More effective systemic therapies are needed if we are to have an impact on the morbidity and mortality caused by the disease. (5)