Any patient experiencing worsening of disease as judged by the Investigator such as a visual acuity loss of 15 letters or more (in the study eye) based on Best Corrected Visual Acuity(BCVA) measurements may be treated with any therapy (including laser photocoagulation, intravitreal or periocular steroid injection, or intravitreal anti-vascular endothelial growth factor [VEGF]) that the Investigator deems appropriate to ensure patient safety.