PSMA, a type II transmembrane protein, is expressed in normal prostate epithelium and highly expressed in ~90% primary PCa and metastases. 68Ga-PSMA-HBED-CC, the most common PSMA PET radiopharmaceutical assessed to date, has shown high sensitivity in detecting recurrent disease. Recently developed 18F-labelled PSMA compounds (e.g. 18F-DCFPyL) offer several technical advantages over 68Ga including high imaging statistic and higher image resolution. Initial preclinical studies have shown favorable tissue binding and the first clinical investigation in 9 patients has shown very high levels of uptake in primary tumors and metastases with further pilot data suggesting additional metastases identified in >20% of patients compared to 68Ga-PSMA.