You will take 4 enzalutamide capsules by mouth at the same time every morning with 1 cup (about 8 ounces) of water. You may take your dose with or without food. The capsules should be swallowed whole and not crushed or cut. If you forget to take a dose, you may take it within 12 hours of the usual dosing time. If you vomit within 30 minutes of taking a dose, you should take the dose again. If you have side effects, your doctor may decide to lower your dose.