40 total patients will be enrolled to the high risk/BMI > 30 cohort. 20 patients must be pre-menopausal and 20 patients must be post-menopausal women. Post-menopausal women are defined as: (1) those ≥ 50 years of age who had not menstruated during the preceding 12 months or who had castrate follicle-stimulating hormone levels (>40IU/L), (2) those who had undergone a bilateral oophorectomy.