The primary endpoint will be virological treatment failure defined as a viral load corresponding to 1000 copies/ml. This could also be expressed as loss of virological response taking death and Loss of Follow Up into account. The secondary endpoints immunological treatment failure (no rise in CD4+ T-cell count at 1 year or decrease with 50% compared to the highest value or CD4+ T-cell count below 100), clinical treatment failure as defined by a new AIDS-defining illness or death due to HIV/AIDS (including TB and opportunistic infection) after starting treatment, and physiological development.