All Adverse Events must be noted in the CRF by marking the Adverse Event check box and then providing a detailed description of the Adverse Event in the notes section of the form. In addition to the standard information captured in the CRF, the notes on the Adverse Event should include information about the specific activity (functional, exercise, or otherwise) that the subject was engaged with at the time of the event, as well any relevant circumstances surrounding the event. Any adverse event must be reviewed by the entire study staff. The adverse event must be reported to the NEIRB in a timely manner and not more than 72 hours after the event.