The rational use of these two molecules could lead to several advantages, such as faster diagnosis, more accurate risk stratification, and optimization of treatment, with consequent benefit to the patient. [85] examined several cases of sepsis caused by different microorganisms, and the differences in the geometric means of the two markers, according to the various classes of microbial agents, seem to indicate that bacteria and fungi stimulate the two markers differently. However, in every case, the two markers' combined use markedly improved the diagnosis independently from the class of pathogen involved (Table 4).