Solo dopo molti anni, dal 1998 a causa del possibile rischio di trasmissione, i Centers for Diseases Control (CDC) di Atlanta (USA) raccomandano di evitare il bacio appassionato con un partner infetto. I CDC nella sezione Frequently asked question alla domanda ""Can I get HIV from kissing?"" Così rispondono: “"No. You cannot get HIV from casually kissing someone (or vice versa) who has HIV. Skin is a greater barrier against HIV. It is not recommended to engage long, open mouth kissing (“French Kissing”) with someone who has HIV and one of you has an open sore in or around the mouth"”.