user11789: I got curious on ffmpeg screen capture capabilities and started messing around with a simple realtime capture test in h264.
ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v libx264 -crf 0 -preset ultrafast capture.mkv

Based on what is said on ffmpeg h264 documentation with the -qp 0 or -crf 0 options libx264 should work in lossless mode.

You can use -qp 0 or -crf 0 to encode a lossless output. Use of -qp is recommended over -crf for lossless because 8-bit and 10-bit x264 use different -crf values for lossless.

This is also repeated in the realtime capture section help when talking about an optional re-encoding with a slower preset to try saving some size:

Note that since the initial recording was lossless, and the re-encode is lossless too, no quality loss is introduced in this process in any way.

Based on this I trusted the guide and assumed using -qp 0 I would achieve a fully lossless workflow ;)
However I found it introduce some loss in particular situations.
So I made another test with the huffyuv codec with this code:
ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v huffyuv capture.mkv

the results:
 
Screen 1: h264 in lossless mode
Screen 2: huffyuv
Based on screens huffyuv is perfect, a true lossless codec while h264 instead compress something here and I'm unable to understand why if it should be setup in a lossless mode.
(huffyuv is identical to a bitmap screenshot of the desktop, I would achieve the same with h264)
Can someone help me figuring it out?

Edit: Adding some ffmpeg dumps as required in comments ;)
h264 run:
ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v libx264 -qp 0 -preset ultrafast capture.mkv  
ffmpeg version N-73411-g5233f25 Copyright (c) 2000-2015 the FFmpeg developers  
  built with gcc 4.9.2 (GCC)  
  configuration: --arch=x86_64 --target-os=mingw32 --cross-prefix=/home/user/san  
dbox/mingw-w64-x86_64/bin/x86_64-w64-mingw32- --pkg-config=pkg-config --enable-g  
pl --enable-libsoxr --enable-fontconfig --enable-libass --enable-libutvideo --en  
able-libbluray --enable-iconv --enable-libtwolame --extra-cflags=-DLIBTWOLAME_ST  
ATIC --enable-libzvbi --enable-libcaca --enable-libmodplug --extra-libs=-lstdc++  
 --extra-libs=-lpng --enable-libvidstab --enable-libx265 --enable-decklink --ext  
ra-libs=-loleaut32 --enable-libx264 --enable-libxvid --enable-libmp3lame --enabl  
e-version3 --enable-zlib --enable-librtmp --enable-libvorbis --enable-libtheora  
--enable-libspeex --enable-libopenjpeg --enable-gnutls --enable-libgsm --enable-  
libfreetype --enable-libopus --disable-w32threads --enable-frei0r --enable-filte  
r=frei0r --enable-libvo-aacenc --enable-bzlib --enable-libxavs --enable-libopenc  
ore-amrnb --enable-libopencore-amrwb --enable-libvo-amrwbenc --enable-libschroed  
inger --enable-libvpx --enable-libilbc --enable-libwavpack --enable-libwebp --en  
able-libgme --enable-dxva2 --enable-libdcadec --enable-avisynth --enable-static  
--disable-shared --extra-cflags= --prefix=/home/user/sandbox/mingw-w64-x86_64/x8  
6_64-w64-mingw32 --extra-libs=-lpsapi --enable-nonfree --enable-libfdk-aac --dis  
able-libfaac --enable-nvenc --enable-runtime-cpudetect  
  libavutil      54. 28.100 / 54. 28.100  
  libavcodec     56. 46.101 / 56. 46.101  
  libavformat    56. 40.100 / 56. 40.100  
  libavdevice    56.  4.100 / 56.  4.100  
  libavfilter     5. 20.100 /  5. 20.100  
  libswscale      3.  1.101 /  3.  1.101  
  libswresample   1.  2.100 /  1.  2.100  
  libpostproc    53.  3.100 / 53.  3.100  
leaving aero onInput #0, dshow, from 'video=screen-capture-recorder':  
  Duration: N/A, start: 362931.503000, bitrate: N/A  
    Stream #0:0: Video: rawvideo, bgr0, 1920x1080, 30 tbr, 10000k tbn, 30 tbc  
No pixel format specified, yuv444p for H.264 encoding chosen.  
Use -pix_fmt yuv420p for compatibility with outdated media players.  
[libx264 @ 00000000004c7e00] using cpu capabilities: MMX2 SSE2Fast SSSE3 SSE4.2  
AVX FMA3 AVX2 LZCNT BMI2  
[libx264 @ 00000000004c7e00] profile High 4:4:4 Predictive, level 4.0, 4:4:4 8-b  
it  
[libx264 @ 00000000004c7e00] 264 - core 144 r2533 c8a773e - H.264/MPEG-4 AVC cod  
ec - Copyleft 2003-2015 - http://www.videolan.org/x264.html - options: cabac=0 r  
ef=1 deblock=0:0:0 analyse=0:0 me=dia subme=0 psy=0 mixed_ref=0 me_range=16 chro  
ma_me=1 trellis=0 8x8dct=0 cqm=0 deadzone=21,11 fast_pskip=0 chroma_qp_offset=0  
threads=6 lookahead_threads=1 sliced_threads=0 nr=0 decimate=1 interlaced=0 blur  
ay_compat=0 constrained_intra=0 bframes=0 weightp=0 keyint=250 keyint_min=25 sce  
necut=0 intra_refresh=0 rc=cqp mbtree=0 qp=0  
Output #0, matroska, to 'capture.mkv':  
  Metadata:  
    encoder         : Lavf56.40.100  
    Stream #0:0: Video: h264 (libx264) (H264 / 0x34363248), yuv444p, 1920x1080,  
q=-1--1, 30 fps, 1k tbn, 30 tbc  
    Metadata:  
      encoder         : Lavc56.46.101 libx264  
Stream mapping:  
  Stream #0:0 -> #0:0 (rawvideo (native) -> h264 (libx264))  
Press [q] to stop, [?] for help  
frame=   11 fps=0.0 q=0.0 size=    2421kB time=00:00:00.20 bitrate=99163.6kbits/  
frame=   22 fps= 22 q=0.0 size=    2538kB time=00:00:00.73 bitrate=28368.6kbits/  
frame=   33 fps= 22 q=0.0 size=    2647kB time=00:00:01.26 bitrate=17116.4kbits/  
frame=   46 fps= 23 q=0.0 size=    2770kB time=00:00:01.80 bitrate=12608.4kbits/  
frame=   58 fps= 23 q=0.0 size=    2842kB time=00:00:02.23 bitrate=10427.1kbits/  
frame=   71 fps= 23 q=0.0 size=    2908kB time=00:00:02.80 bitrate=8508.6kbits/s  
frame=   83 fps= 23 q=0.0 size=    2977kB time=00:00:03.26 bitrate=7467.0kbits/s  
frame=   96 fps= 24 q=0.0 size=    3085kB time=00:00:03.80 bitrate=6649.8kbits/s  
frame=  108 fps= 24 q=0.0 size=    3195kB time=00:00:04.30 bitrate=6084.5kbits/s  
frame=  120 fps= 24 q=0.0 size=    3309kB time=00:00:04.80 bitrate=5645.8kbits/s  
frame=  133 fps= 24 q=0.0 size=    3398kB time=00:00:05.33 bitrate=5219.0kbits/s  
frame=  147 fps= 24 q=0.0 size=    3492kB time=00:00:05.86 bitrate=4876.1kbits/s  
frame=  160 fps= 24 q=0.0 size=    3568kB time=00:00:06.36 bitrate=4591.4kbits/s  
frame=  173 fps= 24 q=0.0 size=    3660kB time=00:00:06.86 bitrate=4366.2kbits/s  
frame=  186 fps= 25 q=0.0 size=    3720kB time=00:00:07.36 bitrate=4136.5kbits/s  
frame=  187 fps= 24 q=-1.0 Lsize=    3737kB time=00:00:07.63 bitrate=4010.9kbits  
/s  
video:3735kB audio:0kB subtitle:0kB other streams:0kB global headers:0kB muxing  
overhead: 0.052628%  
[libx264 @ 00000000004c7e00] frame I:1     Avg QP: 0.00  size:1345491  
[libx264 @ 00000000004c7e00] frame P:186   Avg QP: 0.00  size: 13327  
[libx264 @ 00000000004c7e00] mb I  I16..4: 100.0%  0.0%  0.0%  
[libx264 @ 00000000004c7e00] mb P  I16..4: 16.5%  0.0%  0.0%  P16..4:  0.3%  0.0  
%  0.0%  0.0%  0.0%    skip:83.3%  
[libx264 @ 00000000004c7e00] coded y,u,v intra: 6.1% 3.8% 3.9% inter: 0.2% 0.1%  
0.1%  
[libx264 @ 00000000004c7e00] i16 v,h,dc,p: 96%  4%  0%  0%  
[libx264 @ 00000000004c7e00] kb/s:4008.11  
[dshow @ 00000000004bf760] real-time buffer [screen-capture-recorder] [video inp  
ut] too full or near too full (545% of size: 3041280 [rtbufsize parameter])! fra  
me dropped!  
Exiting normally, received signal 2.  
Terminate batch job (Y/N)?

huffyuv run:
ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v huffyuv capture.mkv  
ffmpeg version N-73411-g5233f25 Copyright (c) 2000-2015 the FFmpeg developers  
  built with gcc 4.9.2 (GCC)  
  configuration: --arch=x86_64 --target-os=mingw32 --cross-prefix=/home/user/san  
dbox/mingw-w64-x86_64/bin/x86_64-w64-mingw32- --pkg-config=pkg-config --enable-g  
pl --enable-libsoxr --enable-fontconfig --enable-libass --enable-libutvideo --en  
able-libbluray --enable-iconv --enable-libtwolame --extra-cflags=-DLIBTWOLAME_ST  
ATIC --enable-libzvbi --enable-libcaca --enable-libmodplug --extra-libs=-lstdc++  
 --extra-libs=-lpng --enable-libvidstab --enable-libx265 --enable-decklink --ext  
ra-libs=-loleaut32 --enable-libx264 --enable-libxvid --enable-libmp3lame --enabl  
e-version3 --enable-zlib --enable-librtmp --enable-libvorbis --enable-libtheora  
--enable-libspeex --enable-libopenjpeg --enable-gnutls --enable-libgsm --enable-  
libfreetype --enable-libopus --disable-w32threads --enable-frei0r --enable-filte  
r=frei0r --enable-libvo-aacenc --enable-bzlib --enable-libxavs --enable-libopenc  
ore-amrnb --enable-libopencore-amrwb --enable-libvo-amrwbenc --enable-libschroed  
inger --enable-libvpx --enable-libilbc --enable-libwavpack --enable-libwebp --en  
able-libgme --enable-dxva2 --enable-libdcadec --enable-avisynth --enable-static  
--disable-shared --extra-cflags= --prefix=/home/user/sandbox/mingw-w64-x86_64/x8  
6_64-w64-mingw32 --extra-libs=-lpsapi --enable-nonfree --enable-libfdk-aac --dis  
able-libfaac --enable-nvenc --enable-runtime-cpudetect  
  libavutil      54. 28.100 / 54. 28.100  
  libavcodec     56. 46.101 / 56. 46.101  
  libavformat    56. 40.100 / 56. 40.100  
  libavdevice    56.  4.100 / 56.  4.100  
  libavfilter     5. 20.100 /  5. 20.100  
  libswscale      3.  1.101 /  3.  1.101  
  libswresample   1.  2.100 /  1.  2.100  
  libpostproc    53.  3.100 / 53.  3.100  
leaving aero onInput #0, dshow, from 'video=screen-capture-recorder':  
  Duration: N/A, start: 362514.497000, bitrate: N/A  
    Stream #0:0: Video: rawvideo, bgr0, 1920x1080, 30 tbr, 10000k tbn, 30 tbc  
[huffyuv @ 0000000000380ae0] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 0000000000377280] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 00000000003b0fc0] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 00000000003b1700] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 0000000000357a00] using huffyuv 2.2.0 or newer interlacing flag  
Output #0, matroska, to 'capture.mkv':  
  Metadata:  
    encoder         : Lavf56.40.100  
    Stream #0:0: Video: huffyuv (HFYU / 0x55594648), rgb24, 1920x1080, q=2-31, 2  
00 kb/s, 30 fps, 1k tbn, 30 tbc  
    Metadata:  
      encoder         : Lavc56.46.101 huffyuv  
Stream mapping:  
  Stream #0:0 -> #0:0 (rawvideo (native) -> huffyuv (native))  
Press [q] to stop, [?] for help  
frame=   12 fps=0.0 q=0.0 size=   23668kB time=00:00:00.50 bitrate=386999.4kbits  
frame=   22 fps= 22 q=0.0 size=   44696kB time=00:00:00.96 bitrate=379033.1kbits  
frame=   35 fps= 23 q=0.0 size=   72074kB time=00:00:01.46 bitrate=402750.2kbits  
frame=   49 fps= 24 q=0.0 size=  101620kB time=00:00:02.00 bitrate=416236.4kbits  
frame=   63 fps= 25 q=0.0 size=  131190kB time=00:00:02.50 bitrate=429712.0kbits  
frame=   78 fps= 26 q=0.0 size=  162896kB time=00:00:03.03 bitrate=439829.0kbits  
frame=   83 fps= 26 q=0.0 Lsize=  175587kB time=00:00:03.23 bitrate=444776.1kbit  
s/s  
video:175582kB audio:0kB subtitle:0kB other streams:0kB global headers:0kB muxin  
g overhead: 0.002479%  
[dshow @ 000000000034f420] real-time buffer [screen-capture-recorder] [video inp  
ut] too full or near too full (545% of size: 3041280 [rtbufsize parameter])! fra  
me dropped!  
Exiting normally, received signal 2.  
Terminate batch job (Y/N)?  

note: even if I have accepted the answer for general purposes I tend to use the soluction provided by @paul-b-mahol with the libx264rgb encoder.


user34681: Hellow. You need 4:4:4 pixel format and High444 profile in libx264 or h264_nvenc or other h264 encoder. And I guess that qp 0 is better then crf 0. For example:
-c:v h264_nvenc -qp 0 -pix_fmt yuv444p -profile:v high444p

For screenrecording gdigrab is the best way.
P.S.: I use Nvidia HWacel of my GeForce1660 Ti Max-Q. It's very fast!

user1871: It's an artifact of the player, not the encoder.
I used the command below to generate a RGB format capture in HuffYUV
ffmpeg -f dshow -video_size 1920x1080 -framerate 30 -i video="screen-capture-recorder" -c:v huffyuv -t 5 cap.mkv

Then transcoded the file to
x264 lossless RGB
ffmpeg -i cap.mkv -c:v libx264rgb -crf 0 -preset ultrafast h264rgb.mkv

HuffYUV YUV 4:2:2
ffmpeg -i cap.mkv -c:v huffyuv -pix_fmt yuv422p huffyuv.mkv

x264 lossless YUV 4:2:2
ffmpeg -i cap.mkv -c:v libx264 -crf 0 -preset ultrafast -pix_fmt yuv422p h264yuv.mkv


Then, using the SSIM metric, compared the HuffYUV and x264 RGB files
ffmpeg -i h264rgb.mkv -i cap.mkv -filter_complex ssim -f null -

which resulted in
SSIM R:1.000000 (inf) G:1.000000 (inf) B:1.000000 (inf) All:1.000000 (inf)

And the HuffYUV and x264 YUV files
ffmpeg -i h264yuv.mkv -i huffyuv.mkv -filter_complex ssim -f null -

Result
SSIM Y:1.000000 (inf) U:1.000000 (inf) V:1.000000 (inf) All:1.000000 (inf)

So, x264 does produce lossless output.

11789: <p>I got curious on ffmpeg screen capture capabilities and started messing around with a simple realtime capture test in h264.</p>

<pre><code>ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v libx264 -crf 0 -preset ultrafast capture.mkv
</code></pre>

<p>Based on what is said on ffmpeg h264 documentation with the <code>-qp 0</code> or <code>-crf 0</code> options libx264 should work in lossless mode.</p>

<blockquote>
  <p><em>You can use -qp 0 or -crf 0 to encode a lossless output. Use of -qp is recommended over -crf for lossless because 8-bit and 10-bit x264 use different -crf values for lossless.</em></p>
</blockquote>

<p>This is also repeated in the realtime capture section help when talking about an optional re-encoding with a slower preset to try saving some size:</p>

<blockquote>
  <p><em>Note that since the initial recording was lossless, and the re-encode is lossless too, no quality loss is introduced in this process in any way.</em></p>
</blockquote>

<p>Based on this I trusted the guide and assumed using -qp 0 I would achieve a fully lossless workflow ;)</p>

<p>However I found it introduce some loss in particular situations.</p>

<p>So I made another test with the huffyuv codec with this code:</p>

<pre><code>ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v huffyuv capture.mkv
</code></pre>

<p>the results:</p>

<p><a href="https://i.stack.imgur.com/CqIw5.png" rel="noreferrer"><img src="https://i.stack.imgur.com/CqIw5.png" alt="Screen Capture encoded in h264"></a> <a href="https://i.stack.imgur.com/6Bn3e.png" rel="noreferrer"><img src="https://i.stack.imgur.com/6Bn3e.png" alt="Screen Capture encoded in huffyuv"></a></p>

<p>Screen 1: <strong>h264 in lossless mode</strong><br>
Screen 2: <strong>huffyuv</strong></p>

<p>Based on screens <code>huffyuv</code> is perfect, a true lossless codec while <code>h264</code> instead compress something here and I'm unable to understand why if it should be setup in a lossless mode.</p>

<p>(huffyuv is identical to a bitmap screenshot of the desktop, I would achieve the same with h264)</p>

<p>Can someone help me figuring it out?</p>

<hr>

<p>Edit: Adding some ffmpeg dumps as required in comments ;)</p>

<p>h264 run:</p>

<pre><code>ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v libx264 -qp 0 -preset ultrafast capture.mkv  
ffmpeg version N-73411-g5233f25 Copyright (c) 2000-2015 the FFmpeg developers  
  built with gcc 4.9.2 (GCC)  
  configuration: --arch=x86_64 --target-os=mingw32 --cross-prefix=/home/user/san  
dbox/mingw-w64-x86_64/bin/x86_64-w64-mingw32- --pkg-config=pkg-config --enable-g  
pl --enable-libsoxr --enable-fontconfig --enable-libass --enable-libutvideo --en  
able-libbluray --enable-iconv --enable-libtwolame --extra-cflags=-DLIBTWOLAME_ST  
ATIC --enable-libzvbi --enable-libcaca --enable-libmodplug --extra-libs=-lstdc++  
 --extra-libs=-lpng --enable-libvidstab --enable-libx265 --enable-decklink --ext  
ra-libs=-loleaut32 --enable-libx264 --enable-libxvid --enable-libmp3lame --enabl  
e-version3 --enable-zlib --enable-librtmp --enable-libvorbis --enable-libtheora  
--enable-libspeex --enable-libopenjpeg --enable-gnutls --enable-libgsm --enable-  
libfreetype --enable-libopus --disable-w32threads --enable-frei0r --enable-filte  
r=frei0r --enable-libvo-aacenc --enable-bzlib --enable-libxavs --enable-libopenc  
ore-amrnb --enable-libopencore-amrwb --enable-libvo-amrwbenc --enable-libschroed  
inger --enable-libvpx --enable-libilbc --enable-libwavpack --enable-libwebp --en  
able-libgme --enable-dxva2 --enable-libdcadec --enable-avisynth --enable-static  
--disable-shared --extra-cflags= --prefix=/home/user/sandbox/mingw-w64-x86_64/x8  
6_64-w64-mingw32 --extra-libs=-lpsapi --enable-nonfree --enable-libfdk-aac --dis  
able-libfaac --enable-nvenc --enable-runtime-cpudetect  
  libavutil      54. 28.100 / 54. 28.100  
  libavcodec     56. 46.101 / 56. 46.101  
  libavformat    56. 40.100 / 56. 40.100  
  libavdevice    56.  4.100 / 56.  4.100  
  libavfilter     5. 20.100 /  5. 20.100  
  libswscale      3.  1.101 /  3.  1.101  
  libswresample   1.  2.100 /  1.  2.100  
  libpostproc    53.  3.100 / 53.  3.100  
leaving aero onInput #0, dshow, from 'video=screen-capture-recorder':  
  Duration: N/A, start: 362931.503000, bitrate: N/A  
    Stream #0:0: Video: rawvideo, bgr0, 1920x1080, 30 tbr, 10000k tbn, 30 tbc  
No pixel format specified, yuv444p for H.264 encoding chosen.  
Use -pix_fmt yuv420p for compatibility with outdated media players.  
[libx264 @ 00000000004c7e00] using cpu capabilities: MMX2 SSE2Fast SSSE3 SSE4.2  
AVX FMA3 AVX2 LZCNT BMI2  
[libx264 @ 00000000004c7e00] profile High 4:4:4 Predictive, level 4.0, 4:4:4 8-b  
it  
[libx264 @ 00000000004c7e00] 264 - core 144 r2533 c8a773e - H.264/MPEG-4 AVC cod  
ec - Copyleft 2003-2015 - http://www.videolan.org/x264.html - options: cabac=0 r  
ef=1 deblock=0:0:0 analyse=0:0 me=dia subme=0 psy=0 mixed_ref=0 me_range=16 chro  
ma_me=1 trellis=0 8x8dct=0 cqm=0 deadzone=21,11 fast_pskip=0 chroma_qp_offset=0  
threads=6 lookahead_threads=1 sliced_threads=0 nr=0 decimate=1 interlaced=0 blur  
ay_compat=0 constrained_intra=0 bframes=0 weightp=0 keyint=250 keyint_min=25 sce  
necut=0 intra_refresh=0 rc=cqp mbtree=0 qp=0  
Output #0, matroska, to 'capture.mkv':  
  Metadata:  
    encoder         : Lavf56.40.100  
    Stream #0:0: Video: h264 (libx264) (H264 / 0x34363248), yuv444p, 1920x1080,  
q=-1--1, 30 fps, 1k tbn, 30 tbc  
    Metadata:  
      encoder         : Lavc56.46.101 libx264  
Stream mapping:  
  Stream #0:0 -&gt; #0:0 (rawvideo (native) -&gt; h264 (libx264))  
Press [q] to stop, [?] for help  
frame=   11 fps=0.0 q=0.0 size=    2421kB time=00:00:00.20 bitrate=99163.6kbits/  
frame=   22 fps= 22 q=0.0 size=    2538kB time=00:00:00.73 bitrate=28368.6kbits/  
frame=   33 fps= 22 q=0.0 size=    2647kB time=00:00:01.26 bitrate=17116.4kbits/  
frame=   46 fps= 23 q=0.0 size=    2770kB time=00:00:01.80 bitrate=12608.4kbits/  
frame=   58 fps= 23 q=0.0 size=    2842kB time=00:00:02.23 bitrate=10427.1kbits/  
frame=   71 fps= 23 q=0.0 size=    2908kB time=00:00:02.80 bitrate=8508.6kbits/s  
frame=   83 fps= 23 q=0.0 size=    2977kB time=00:00:03.26 bitrate=7467.0kbits/s  
frame=   96 fps= 24 q=0.0 size=    3085kB time=00:00:03.80 bitrate=6649.8kbits/s  
frame=  108 fps= 24 q=0.0 size=    3195kB time=00:00:04.30 bitrate=6084.5kbits/s  
frame=  120 fps= 24 q=0.0 size=    3309kB time=00:00:04.80 bitrate=5645.8kbits/s  
frame=  133 fps= 24 q=0.0 size=    3398kB time=00:00:05.33 bitrate=5219.0kbits/s  
frame=  147 fps= 24 q=0.0 size=    3492kB time=00:00:05.86 bitrate=4876.1kbits/s  
frame=  160 fps= 24 q=0.0 size=    3568kB time=00:00:06.36 bitrate=4591.4kbits/s  
frame=  173 fps= 24 q=0.0 size=    3660kB time=00:00:06.86 bitrate=4366.2kbits/s  
frame=  186 fps= 25 q=0.0 size=    3720kB time=00:00:07.36 bitrate=4136.5kbits/s  
frame=  187 fps= 24 q=-1.0 Lsize=    3737kB time=00:00:07.63 bitrate=4010.9kbits  
/s  
video:3735kB audio:0kB subtitle:0kB other streams:0kB global headers:0kB muxing  
overhead: 0.052628%  
[libx264 @ 00000000004c7e00] frame I:1     Avg QP: 0.00  size:1345491  
[libx264 @ 00000000004c7e00] frame P:186   Avg QP: 0.00  size: 13327  
[libx264 @ 00000000004c7e00] mb I  I16..4: 100.0%  0.0%  0.0%  
[libx264 @ 00000000004c7e00] mb P  I16..4: 16.5%  0.0%  0.0%  P16..4:  0.3%  0.0  
%  0.0%  0.0%  0.0%    skip:83.3%  
[libx264 @ 00000000004c7e00] coded y,u,v intra: 6.1% 3.8% 3.9% inter: 0.2% 0.1%  
0.1%  
[libx264 @ 00000000004c7e00] i16 v,h,dc,p: 96%  4%  0%  0%  
[libx264 @ 00000000004c7e00] kb/s:4008.11  
[dshow @ 00000000004bf760] real-time buffer [screen-capture-recorder] [video inp  
ut] too full or near too full (545% of size: 3041280 [rtbufsize parameter])! fra  
me dropped!  
Exiting normally, received signal 2.  
Terminate batch job (Y/N)?
</code></pre>

<p>huffyuv run:</p>

<pre><code>ffmpeg -f dshow -i video="screen-capture-recorder" -video_size 1920x1080 -framerate 30 -c:v huffyuv capture.mkv  
ffmpeg version N-73411-g5233f25 Copyright (c) 2000-2015 the FFmpeg developers  
  built with gcc 4.9.2 (GCC)  
  configuration: --arch=x86_64 --target-os=mingw32 --cross-prefix=/home/user/san  
dbox/mingw-w64-x86_64/bin/x86_64-w64-mingw32- --pkg-config=pkg-config --enable-g  
pl --enable-libsoxr --enable-fontconfig --enable-libass --enable-libutvideo --en  
able-libbluray --enable-iconv --enable-libtwolame --extra-cflags=-DLIBTWOLAME_ST  
ATIC --enable-libzvbi --enable-libcaca --enable-libmodplug --extra-libs=-lstdc++  
 --extra-libs=-lpng --enable-libvidstab --enable-libx265 --enable-decklink --ext  
ra-libs=-loleaut32 --enable-libx264 --enable-libxvid --enable-libmp3lame --enabl  
e-version3 --enable-zlib --enable-librtmp --enable-libvorbis --enable-libtheora  
--enable-libspeex --enable-libopenjpeg --enable-gnutls --enable-libgsm --enable-  
libfreetype --enable-libopus --disable-w32threads --enable-frei0r --enable-filte  
r=frei0r --enable-libvo-aacenc --enable-bzlib --enable-libxavs --enable-libopenc  
ore-amrnb --enable-libopencore-amrwb --enable-libvo-amrwbenc --enable-libschroed  
inger --enable-libvpx --enable-libilbc --enable-libwavpack --enable-libwebp --en  
able-libgme --enable-dxva2 --enable-libdcadec --enable-avisynth --enable-static  
--disable-shared --extra-cflags= --prefix=/home/user/sandbox/mingw-w64-x86_64/x8  
6_64-w64-mingw32 --extra-libs=-lpsapi --enable-nonfree --enable-libfdk-aac --dis  
able-libfaac --enable-nvenc --enable-runtime-cpudetect  
  libavutil      54. 28.100 / 54. 28.100  
  libavcodec     56. 46.101 / 56. 46.101  
  libavformat    56. 40.100 / 56. 40.100  
  libavdevice    56.  4.100 / 56.  4.100  
  libavfilter     5. 20.100 /  5. 20.100  
  libswscale      3.  1.101 /  3.  1.101  
  libswresample   1.  2.100 /  1.  2.100  
  libpostproc    53.  3.100 / 53.  3.100  
leaving aero onInput #0, dshow, from 'video=screen-capture-recorder':  
  Duration: N/A, start: 362514.497000, bitrate: N/A  
    Stream #0:0: Video: rawvideo, bgr0, 1920x1080, 30 tbr, 10000k tbn, 30 tbc  
[huffyuv @ 0000000000380ae0] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 0000000000377280] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 00000000003b0fc0] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 00000000003b1700] using huffyuv 2.2.0 or newer interlacing flag  
[huffyuv @ 0000000000357a00] using huffyuv 2.2.0 or newer interlacing flag  
Output #0, matroska, to 'capture.mkv':  
  Metadata:  
    encoder         : Lavf56.40.100  
    Stream #0:0: Video: huffyuv (HFYU / 0x55594648), rgb24, 1920x1080, q=2-31, 2  
00 kb/s, 30 fps, 1k tbn, 30 tbc  
    Metadata:  
      encoder         : Lavc56.46.101 huffyuv  
Stream mapping:  
  Stream #0:0 -&gt; #0:0 (rawvideo (native) -&gt; huffyuv (native))  
Press [q] to stop, [?] for help  
frame=   12 fps=0.0 q=0.0 size=   23668kB time=00:00:00.50 bitrate=386999.4kbits  
frame=   22 fps= 22 q=0.0 size=   44696kB time=00:00:00.96 bitrate=379033.1kbits  
frame=   35 fps= 23 q=0.0 size=   72074kB time=00:00:01.46 bitrate=402750.2kbits  
frame=   49 fps= 24 q=0.0 size=  101620kB time=00:00:02.00 bitrate=416236.4kbits  
frame=   63 fps= 25 q=0.0 size=  131190kB time=00:00:02.50 bitrate=429712.0kbits  
frame=   78 fps= 26 q=0.0 size=  162896kB time=00:00:03.03 bitrate=439829.0kbits  
frame=   83 fps= 26 q=0.0 Lsize=  175587kB time=00:00:03.23 bitrate=444776.1kbit  
s/s  
video:175582kB audio:0kB subtitle:0kB other streams:0kB global headers:0kB muxin  
g overhead: 0.002479%  
[dshow @ 000000000034f420] real-time buffer [screen-capture-recorder] [video inp  
ut] too full or near too full (545% of size: 3041280 [rtbufsize parameter])! fra  
me dropped!  
Exiting normally, received signal 2.  
Terminate batch job (Y/N)?  
</code></pre>

<p>note: even if I have accepted the answer for general purposes I tend to use the soluction provided by @paul-b-mahol with the <strong>libx264rgb</strong> encoder.</p>

<hr>
 34681: <p>Hellow. You need 4:4:4 pixel format and High444 profile in libx264 or h264_nvenc or other h264 encoder. And I guess that <code>qp 0</code> is better then <code>crf 0</code>. For example:</p>
<pre><code>-c:v h264_nvenc -qp 0 -pix_fmt yuv444p -profile:v high444p
</code></pre>
<p>For screenrecording <a href="https://trac.ffmpeg.org/wiki/Capture/Desktop" rel="nofollow noreferrer">gdigrab</a> is the best way.
P.S.: I use Nvidia HWacel of my GeForce1660 Ti Max-Q. It's very fast!</p>
 1871: <p>It's an artifact of the player, not the encoder.</p>

<p>I used the command below to generate a RGB format capture in HuffYUV</p>

<pre><code>ffmpeg -f dshow -video_size 1920x1080 -framerate 30 -i video="screen-capture-recorder" -c:v huffyuv -t 5 cap.mkv
</code></pre>

<p>Then transcoded the file to</p>

<p>x264 lossless RGB</p>

<pre><code>ffmpeg -i cap.mkv -c:v libx264rgb -crf 0 -preset ultrafast h264rgb.mkv
</code></pre>

<p>HuffYUV YUV 4:2:2</p>

<pre><code>ffmpeg -i cap.mkv -c:v huffyuv -pix_fmt yuv422p huffyuv.mkv
</code></pre>

<p>x264 lossless YUV 4:2:2</p>

<pre><code>ffmpeg -i cap.mkv -c:v libx264 -crf 0 -preset ultrafast -pix_fmt yuv422p h264yuv.mkv
</code></pre>

<hr>

<p>Then, using the SSIM metric, compared the HuffYUV and x264 RGB files</p>

<pre><code>ffmpeg -i h264rgb.mkv -i cap.mkv -filter_complex ssim -f null -
</code></pre>

<p>which resulted in</p>

<pre><code>SSIM R:1.000000 (inf) G:1.000000 (inf) B:1.000000 (inf) All:1.000000 (inf)
</code></pre>

<p>And the HuffYUV and x264 YUV files</p>

<pre><code>ffmpeg -i h264yuv.mkv -i huffyuv.mkv -filter_complex ssim -f null -
</code></pre>

<p>Result</p>

<pre><code>SSIM Y:1.000000 (inf) U:1.000000 (inf) V:1.000000 (inf) All:1.000000 (inf)
</code></pre>

<p>So, x264 does produce lossless output.</p>
