user34205: I was trying to make some recordings of a game (with OBS), but it wasn't really good even with "lossless" options. Some part of the interface was just pixelated... After a while I realized that the chromatic subsampling should cause the problem, as the pixelated interface is red. (In OBS the default color format is NV12, using RGB instead - without subsampling - it was all good.)
Is there a workaround to keep the resolution of the interface intact, but still do some kind of chromatic subsampling? (Maybe with some other color encoding than YUV?)
It's Ok if I need to make the recordings without subsampling, and than convert/transcode the videos. I would do it anyway, as OBS can't record with hevc_qsv. Also I don't have an intent to publish these videos on the internet. (Probably I'd like to store the videos using H265 or AV1, to obtain the best compression.)

user26140: No. Almost all video on the planet is limited YUV420 (all Blu-rays, even HEVC ones with Dolby Vision, all Youtube, only some satellite FEEDs not for consumers use 4:2:2). Sorry. Of course, there is RGB and even mathematically lossless mode in all common encoders, H.264/AV1/VP9/HEVC... For lossless AV1 see https://trac.ffmpeg.org/ticket/7600
But, alas. It is not used at all.
Only Dolby Vision in profile 5 that is not HDR10 compatible (it uses IPTPQc2 color instead of YCbCr and FULL RANGE) can be good enough for you. It still uses 4:x:x chroma but because of new encoding it is much better looking!

34205: <p>I was trying to make some recordings of a game (with OBS), but it wasn't really good even with &quot;lossless&quot; options. Some part of the interface was just pixelated... After a while I realized that the chromatic subsampling should cause the problem, as the pixelated interface is red. (In OBS the default color format is NV12, using RGB instead - without subsampling - it was all good.)</p>
<p>Is there a workaround to keep the resolution of the interface intact, but still do some kind of chromatic subsampling? (Maybe with some other color encoding than YUV?)<br />
It's Ok if I need to make the recordings without subsampling, and than convert/transcode the videos. I would do it anyway, as OBS can't record with hevc_qsv. Also I don't have an intent to publish these videos on the internet. (Probably I'd like to store the videos using H265 or AV1, to obtain the best compression.)</p>
 26140: <p>No. Almost all video on the planet is limited YUV420 (all Blu-rays, even HEVC ones with Dolby Vision, all Youtube, only some satellite FEEDs not for consumers use 4:2:2). Sorry. Of course, there <strong>is</strong> RGB and <strong>even</strong> mathematically lossless mode in all common encoders, H.264/AV1/VP9/HEVC... For lossless AV1 see <a href="https://trac.ffmpeg.org/ticket/7600" rel="nofollow noreferrer">https://trac.ffmpeg.org/ticket/7600</a></p>
<p>But, alas. It is not used at all.</p>
<p>Only Dolby Vision in profile 5 that is not HDR10 compatible (it uses IPTPQc2 color instead of YCbCr and <strong>FULL RANGE</strong>) can be good enough for you. It still uses 4:x:x chroma but because of new encoding it is much better looking!</p>
