  Briefly, The patient underwent extensive debridement of his right below-knee amputation wound on July 17, 2008.  He underwent debridement of skin, subcutaneous tissue, muscle, and bone to remove the necrotic tissue from the stump.  A wound VAC. was also placed to help accelerate wound healing.  The patient's postoperative course was complicated initially by acute blood-loss anemia, requiring blood transfusion.  He returned to the OR on Monday, July 21, 2008 for irrigation and debridement of his right below-knee amputation and a wound VAC change.  Again, on July 24, 2008, and then again on July 28, 2008, The patient returned to the operating room for irrigation and debridement of his wound and wound VAC change.  Following his procedure on July 28, 2008, The patient began having recurrent episodes of diarrhea, prompting stool cultures and C. difficile assay to be sent.  He was also started on Flagyl, empirically.  C. difficile assay returned positive and the decision was made to continue Flagyl for a full 14-day course.  On July 31, 2008, the patient began experiencing shortness of breath and wheezing after standing to be weighed.  His vital signs remained stable.  However, his oxygen saturation dropped to 93%