Ms. ABC is a pleasant 66-year-old Caucasian female who first palpated a mass in the left posterior arm in spring of 2007.  The mass increased in size and she was seen by her primary care physician and referred to orthopedic surgeon.  MRI showed inflammation and was thought to be secondary to rheumatoid arthritis.  The mass increased in size.  She eventually underwent a partial resection found to have pathologic grade 2 leiomyosarcoma, margins were impossible to assess, but were likely positive.  She was evaluated by Dr. X and Dr. Y and a decision was made to proceed with preoperative chemotherapy.  She began treatment with CIVI-CAD in December 2007.  Her course was complicated by pulmonary embolus, pneumonia, and subdural hematoma while on anticoagulation.  She eventually underwent surgical resection on May 1, 2008 with small area of residual disease, but otherwise clear margins.