 The patient is a very pleasant 57-year old white female, a native of Cuba, being seen for evaluation and treatment of sores in her mouth that she has had for the last 10-12 days.  The patient has a long history of severe and debilitating rheumatoid arthritis for which she has had numerous treatments, but over the past ten years she has been treated with methotrexate quite successfully.  Her dosage has varied somewhere between 20 and 25 mg per week.  About the beginning of this year, her dosage was decreased from 25 mg to 20 mg, but because of the flare of the rheumatoid arthritis, it was increased to 22.5 mg per week.  She has had no problems with methotrexate as far as she knows.  She also took an NSAID about a month ago that was recently continued because of the ulcerations in her mouth.  About two weeks ago, just about the time the stomatitis began she was placed on an antibiotic for suspected upper respiratory infection.  She does not remember the name of the antibiotic.  Although she claims she remembers taking this type of medication in the past without any problems.  She was on that medication three pills a day for three to four days.  She notes no other problems with her skin.  She remembers no allergic reactions to medication.  She has no previous history of fever blisters.  