[{"from": "human", "value": "Based on the given information, design a molecule that meets the desired specifications. The molecule is an orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells."}, {"from": "gpt", "value": "[C][C][C][Branch1][Ring2][C][Ring1][Ring2][C][=Branch1][C][=O][N][Branch2][Ring1][O][C][=Branch1][C][=S][N][Ring1][Branch2][C][=C][N][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][O][C][C][C][N][C][C][Ring1][=Branch1][C][=C][C][=Branch1][#Branch2][=C][Branch1][Branch1][N][=C][Ring1][=Branch1][C][#N][C][Branch1][C][F][Branch1][C][F][F]"}]