[{"from": "human", "value": "Based on the given information, design a molecule that meets the desired specifications. The molecule is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types."}, {"from": "gpt", "value": "[C][C][C][N][S][=Branch1][C][=O][=Branch1][C][=O][N][C][=C][Branch2][Ring1][Branch2][C][=Branch1][=Branch1][=N][C][=N][Ring1][=Branch1][O][C][C][O][C][=N][C][=C][Branch1][Branch1][C][=N][Ring1][=Branch1][Br][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][Br]"}]