[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][Branch2][Ring2][#Branch1][C][Branch2][Ring1][=Branch1][C][=Branch1][Branch2][=C][Branch1][Ring2][N][Ring1][=Branch1][C][C][=Branch1][C][=O][O][C][C][Branch1][C][C][C][C][=C][C][=C][C][=C][Ring1][=Branch1][N+1][=Branch1][C][=O][O-1][C][=Branch1][C][=O][O][C]"}, {"from": "gpt", "value": "The molecule is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension."}]