[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][Branch2][Ring1][N][S][C][=Branch1][Ring2][=C][Ring1][Branch1][C][=Branch1][C][=O][N][C@@H1][Branch1][Branch2][C][C][C][=Branch1][C][=O][O][C][=Branch1][C][=O][O][C][C][C@H1][C][C][=C][Branch1][Branch1][N][C][Ring1][=Branch1][N][=C][Branch1][=Branch1][N][C][Ring1][Branch2][=O][N]"}, {"from": "gpt", "value": "The molecule is a water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation"}]