[{"from": "human", "value": "What can you tell me about this molecule? [C][C@@H1][Branch2][Ring1][P][C@H1][Branch2][Ring1][O][O][C@H1][Ring1][Branch1][N][C][=C][Branch1][#Branch2][C][=Branch1][C][=O][N][C][Ring1][#Branch1][=O][C][Branch1][C][F][Branch1][C][F][F][C][O][O]"}, {"from": "gpt", "value": "The molecule is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and 2.   The combination product of trifluridine with tipiracil marketed as Lonsurf has been approved in Japan, the United States, and the European Union for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In the anticancer therapy, trifluridine acts as a thymidine-based nucleoside metabolic inhibitor that gets incorporated into DNA of cancer cells following cell uptake to aberrate DNA function during cell replication."}]