[{"from": "human", "value": "Provide a description of this molecule. [C][C][C][=C][Branch1][=N][C][=Branch1][=Branch2][=N][C][=Branch1][Ring2][=N][Ring1][=Branch1][N][N][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][Cl]"}, {"from": "gpt", "value": "The molecule is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.  Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR).  DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.  This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)"}]