[{"from": "human", "value": "What can you tell me about this molecule? [C][C][=C][C@H1][Branch2][Branch2][Branch2][C][=Branch1][C][=O][C@@][Branch2][#Branch1][#C][C@H1][Branch2][#Branch1][#Branch2][C][C@@H1][C@][Branch2][=Branch1][#Branch1][C@H1][Ring1][=Branch1][C@@H1][Branch2][Branch1][Ring1][C@@][Branch1][Branch2][C][Ring1][=N][Branch1][C][C][C][Branch2][Ring2][Branch1][C][C@@H1][Ring2][Ring1][C][O][C][=Branch1][C][=O][C@@H1][Branch2][Ring1][=Branch1][C@H1][Branch1][Branch2][C][=C][C][=C][S][Ring1][Branch1][N][C][=Branch1][C][=O][O][C][Branch1][C][C][C][O][O][O][C][=Branch1][C][=O][C][=C][C][=C][C][=C][Ring1][=Branch1][Branch1][=Branch1][C][O][Ring2][Ring2][Branch2][O][C][=Branch1][C][=O][C][O][C][O][C][=Branch1][C][=O][C][C][C][C][C][Ring1][Branch1]"}, {"from": "gpt", "value": "The molecule is a semi-synthetic, orally bioavailable, third-generation taxane derivative and microtubule-stabilizing agent, with potential antineoplastic activity. Upon administration, simotaxel binds to tubulin, promotes microtubule assembly and stabilization, and prevents microtubule depolymerization. This results in G2/M arrest, apoptosis and the inhibition of cell proliferation in susceptible tumor cells. This agent is a poor substrate for P-glycoprotein-related drug resistance mechanisms; therefore, it may be useful for treating multi-drug resistant tumors. MST-997 is more potent than paclitaxel and docetaxel and overcomes paclitaxel and docetaxel resistance in certain tumor cell types."}]