[{"from": "human", "value": "What can you tell me about this molecule? [C][C][Branch1][C][C][C][=Branch1][C][=O][O][C][C@@H1][C@H1][Branch2][Ring1][O][C@@][Branch2][Ring1][Ring1][C@@H1][Branch1][Ring2][O][Ring1][Branch1][N][C][=C][C][=Branch1][=Branch1][=N][C][Ring1][=Branch1][=O][N][Branch1][C][C][F][O][C][=Branch1][C][=O][C][Branch1][C][C][C]"}, {"from": "gpt", "value": "The molecule is an orally available prodrug of PSI-6130 which is a selective cytidine nucleoside analogue and non-cytotoxic hepatitis C virus (HCV) polymerase inhibitor. After intracellular uptake, mericitabine is phosphorylated into two active triphosphate metabolites, which disable HCV RNA-dependent RNA polymerase (non-structural protein 5B; NS5B) upon binding. This results in the blockage of viral HCV RNA production and thus viral replication. This agent has a high barrier to resistance, however, a substitution mutation (S282T) on HCV NS5B impairs mericitabine's activity significantly."}]