[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C@@][C][C][C@][Branch2][Branch1][#Branch2][C][C][C][Branch2][Ring2][S][C][C@H1][Ring1][=Branch1][C@H1][Ring1][#Branch2][C][=Branch1][C][=O][C][=C][C@][Ring1][#C][Branch2][Ring1][N][C][C][C@@H1][C@@][Ring1][=Branch1][Branch2][Ring1][C][C][=C][Branch1][N][C][=Branch1][C][=O][C][Ring1][#Branch1][Branch1][C][C][C][C][#N][C][C][Branch1][C][C][C][N][C][=Branch1][C][=O][C][Branch1][C][C][Branch1][C][F][F]"}, {"from": "gpt", "value": "The molecule is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, omaveloxolone activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress."}]