[{"from": "human", "value": "Provide a description of this molecule. [C][C][Branch1][C][C][Branch1][C][C][C][=C][Branch1][=Branch1][N][=C][N][Ring1][Branch1][/C][=C][/C][=Branch1][C][=O][N][/C][=Branch1][#Branch2][=C][\\C][=C][C][=C][C][=C][Ring1][=Branch1][/C][=Branch1][C][=O][N][\\-Ring1][#C]"}, {"from": "gpt", "value": "The molecule is an orally active diketopiperazine derivative with potential antineoplastic activity. Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division. In addition, plinabulin may also inhibit growth of proliferating vascular endothelial cells, thereby disrupting the function of tumor vasculature that further contributes to a decrease in tumor cell proliferation."}]