[{"from": "human", "value": "What can you tell me about this molecule? [C][C@H1][Branch1][S][C@@H1][C@H1][Branch1][Ring2][O][Ring1][Branch1][C@H1][Branch1][Branch1][C][O][Ring1][=Branch1][O][O]"}, {"from": "gpt", "value": "The molecule is an organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area."}]