[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C][=N][N][Branch2][Branch1][Branch1][C][=C][Ring1][Branch1][C][=C][Branch2][Ring2][#Branch2][C][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][C][=C][Branch1][Branch1][C][=N][Ring1][#Branch1][N][Branch2][Ring1][Branch1][C][=Branch1][C][=O][N][Ring1][Branch2][C][=C][Branch1][=Branch2][C][=N][C][=C][Ring1][=Branch1][O][C][F][C][O][C][C]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable ATP-competitive inhibitor of ataxia telangiectasia mutated kinase (ATM), with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, M4076 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, by preventing DNA damage repair, M4076 sensitizes tumor cells to chemo- and radiotherapy and increases their anti-tumor activity. ATM, a serine/threonine protein kinase upregulated in a variety of cancer cell types, is activated in response to DNA damage and plays a key role in DNA-strand repair."}]