[{"from": "human", "value": "What can you tell me about this molecule? [C][C@][C][C][C][N][Ring1][Branch1][C][C][=N][N][C][=Branch1][C][=O][C][=C][C][Ring1][Branch2][=C][Ring1][#C][N][C][Ring1][Branch1][=C][C][=Branch1][Ring2][=C][Ring1][=Branch2][F]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP), with potential antineoplastic activity. Upon administration, pamiparib selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. PARP is activated by single-strand DNA breaks and, subsequently, catalyzes post-translational ADP-ribosylation of nuclear proteins which then transduce signals to recruit other proteins to repair damaged DNA. Pamiparib may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance."}]