[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][C][C][C][=N][C][=Branch2][Ring2][Ring2][=C][Branch2][Ring1][=C][N][Ring1][Branch1][C][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][=C][C][=C][C][=C][Ring1][=Branch1][C][=N][N][=N][N-1][Ring1][Branch1][C][O][Cl].[C][N][C][=C][C][=Branch2][Ring1][#Branch2][=C][Branch1][#C][C][=C][Ring1][=Branch1][S][=Branch1][C][=O][=Branch1][C][=O][N][Ring1][N][S][=Branch1][C][=O][=Branch1][C][=O][N][Cl].[K+1]"}, {"from": "gpt", "value": "The molecule is a combination preparation of a synthetic angiotensin II antagonist and a diuretic thiazide, with antihypertensive activity. Losartan, and its metabolite, selectively and competitively block the binding of angiotensin II to the angiotensin II (AT1) receptor. As a result, angiotensin II-AT1 mediated physiological effects such as vasoconstriction and stimulation of aldosterone synthesis and secretion, which regulates extracellular sodium concentration, are blocked. Hydrochlorothiazide inhibits electrolytes reabsorption via binding to Na-Cl cotransporter on the renal distal tubular, thereby increasing excretion of sodium, potassium, chloride, bicarbonate and water. Both agents lead to a reduction in blood pressure."}]