[{"from": "human", "value": "Could you provide a description of this molecule? [C][C][C][Ring1][Ring1][C][O][C][=C][Branch2][Ring1][#Branch2][C][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][C][=Branch1][C][=O][N][C][=C][Branch1][Branch2][C][=N][C][=C][Ring1][=Branch1][Cl][Cl][O][C][Branch1][C][F][F]"}, {"from": "gpt", "value": "The molecule is a highly selective phosphodiesterase-4 (PDE4) inhibitor first approved in the EU in April 2010 for the management of chronic obstructive pulmonary disease. PDE4 is a major cyclic-3',5\u2032-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells like those of the smooth muscle or epithelium. The resultant increase in intracellular cAMP induced by roflumilast's inhibition of PDE4 is thought to mediate its disease-modifying effects, although its precise mechanism of action has yet to be elucidated."}]