[{"from": "human", "value": "Please give me some details about this molecule. [C][N][C][=Branch1][C][=O][C@@H1][C@H1][Branch2][Ring2][Branch2][C@H1][Branch2][Ring2][Ring1][C@@H1][Branch1][Ring2][O][Ring1][Branch1][N][C][=N][C][=C][Branch1][=Branch2][N][=C][N][=C][Ring1][=Branch1][Ring1][=Branch2][N][C][C][=C][C][=Branch1][=Branch1][=C][C][=C][Ring1][=Branch1][I][O][O]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable, adenosine A3 receptor (A3AR) agonist with potential anti-inflammatory activity. Upon administration, piclidenoson selectively targets, binds to and activates the cell surface-expressed A3AR, thereby activating transduction pathways in which A3AR plays a key role. This inhibits nuclear factor-kappa B (NF-kB) signaling and inhibits inflammatory cytokine production, such as tumor necrosis factor (TNF) and several interleukins. A3AR, a G protein-coupled receptor, plays a key role in many inflammatory diseases, and in certain types of cancer."}]