[{"from": "human", "value": "Please give me some details about this molecule. [C][C@@H1][Branch2][Ring1][P][C@H1][Branch2][Ring1][O][O][C@H1][Ring1][Branch1][N][C][=C][Branch1][=N][C][=Branch1][C][=O][N][C][=Branch1][Ring2][=N][Ring1][#Branch1][N][N][C][Ring1][O][=O][C][O][O]"}, {"from": "gpt", "value": "The molecule is a major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative DNA damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is formed through the reaction of guanine with reactive oxygen species. Although normally repaired and removed by the base excision repair mechanism, 8-oxo-dG can potentially mispair with deoxyadenine leading to G-to-T transversion mutations, which cause frequent recombinations and single nucleotide polymorphisms (SNPs) in the human genome. The concentration of 8-oxo-dG within a cell is a measurement of oxidative stress and may thus be used to assess the extent of physiological and environmental damage to DNA."}]