[{"from": "human", "value": "Describe this molecule. [C][C@@H1][O][C][C@@H1][C@@H1][Branch1][Ring2][O][Ring1][=Branch1][C@@H1][Branch2][=Branch1][=Branch2][C@H1][Branch2][=Branch1][Ring2][C@@H1][Branch1][Ring2][O][Ring1][#Branch1][O][C@H1][C@H1][C][O][C][=Branch1][C][=O][C@@H1][Ring1][=Branch1][C@@H1][Branch2][Ring1][C][C][=C][C][=C][Branch1][#Branch1][C][=C][Ring1][=C][Ring1][=Branch1][O][C][O][Ring1][#Branch1][C][=C][C][=Branch2][Ring1][Branch1][=C][Branch1][=Branch2][C][=Branch1][Ring2][=C][Ring1][=Branch1][O][C][O][P][=Branch1][C][=O][Branch1][C][O][O][O][C][O][O]"}, {"from": "gpt", "value": "The molecule is a phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04)"}]