[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C][=C][Branch2][Ring2][Branch2][C][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][N][C][=N][C][=N][C][=C][Ring1][=Branch1][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][C][=N][C][Branch1][Branch1][C][O][Ring1][Branch1][Branch1][C][C][C][O][C][=C][C][=N][C][=N][N][Ring1][Branch1][C][=C][Ring1][=Branch2]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. Tucatinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation."}]