[{"from": "human", "value": "Please give me some details about this molecule. [C][C][C][=Branch1][C][=O][N][Branch2][Branch1][Ring1][C@@H1][Ring1][=Branch1][C][=Branch1][C][=O][N][Branch1][N][C][=C][C][=Branch1][=Branch1][=C][N][=C][Ring1][=Branch1][F][C@@H1][Branch1][#Branch2][C][=C][C][=C][C][=C][Ring1][=Branch1][Cl][C][=Branch1][C][=O][N][C][C][C][Branch1][Ring2][C][Ring1][Ring2][Branch1][C][F][F][C][=N][C][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][C][#N]"}, {"from": "gpt", "value": "The molecule is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. IDH1, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG."}]