[{"from": "human", "value": "Describe this molecule. [C][C][N][Branch2][Ring1][=C][C][=Branch1][C][=O][C][N][Ring1][#Branch1][C][C][=C][N][=C][N][Ring1][Branch1][C][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][#N][C][=C][C][=Branch1][=Branch1][=C][C][=C][Ring1][=Branch1][Cl].[Cl]"}, {"from": "gpt", "value": "The molecule is a benzonitrile derivative capable of inhibiting some prenyltransferases. L-778,123 is a dual inhibitor of farnesyl:protein and geranylgeranyl:protein transferases; both enzymes catalyze prenylation of oncoprotein KRAS, a prerequisite step in activation of KRAS in signal transduction pathway of apoptosis. Although this agent was developed in part as an anti-KRAS agent, L-778,123 failed in a Phase I trial to inhibit KRAS, which is associated with many types of solid tumors."}]