[{"from": "human", "value": "Please give me some details about this molecule. [2H][C][Branch1][C][2H][Branch1][C][2H][N][C][=Branch1][C][=O][C][=N][N][=C][Branch2][Ring1][N][C][=C][Ring1][=Branch1][N][C][=C][C][=C][C][=Branch1][=Branch1][=C][Ring1][=Branch1][O][C][C][=N][N][Branch1][Branch1][C][=N][Ring1][Branch1][C][N][C][=Branch1][C][=O][C][C][C][Ring1][Ring1]"}, {"from": "gpt", "value": "The molecule is a novel oral selective tyrosine kinase 2 (TYK2) inhibitor. Unlike other Janus kinase 1/2/3 inhibitors that bind to the conserved active domain of these non-receptor tyrosine kinases, deucravacitinib binds to the regulatory domain of TYK2 with high selectivity to this therapeutic target. This selectivity towards TYK2 may lead to an improved safety profile of deucravacitinib, as nonselective JAK inhibitors are associated with a range of adverse effects such as altered cholesterol and triglyceride levels and liver and kidney dysfunction.   Deucravacitinib was first approved by the FDA in September 2022 to treat moderate-to-severe plaque psoriasis. It was later approved by Health Canada in November 2022."}]