[{"from": "human", "value": "Provide a brief overview of this molecule. [2H][C][=C][Branch1][=N][C][=Branch1][=Branch2][=N][C][=Branch1][Ring2][=N][Ring1][=Branch1][C][2H][C][=C][C][=Branch1][=Branch1][=N][C][=N][Ring1][=Branch1][N][C][C@@H1][Branch1][C][C][C][=C][C][=C][C][=C][Branch1][=Branch2][C][=C][N][=C][Ring1][=Branch1][Ring1][#Branch2][C][=Branch1][C][=O][N][C]"}, {"from": "gpt", "value": "The molecule is an ATP-competitive inhibitor of the catalytic subunit of DNA-dependent protein kinase (DNA-PK), with potential sensitizing and enhancing activities for both chemo- and radiotherapies. Upon administration, DNA-PK inhibitor VX-984 binds to and inhibits the catalytic subunit of DNA-PK, thereby interfering with the non-homologous end joining (NHEJ) process and preventing repair of DNA double strand breaks (DSBs) caused by ionizing radiation or chemotherapeutic treatment. This increases chemo- and radiotherapy cytotoxicity and leads to enhanced tumor cell death. The enhanced ability of tumor cells to repair DSBs plays a major role in the resistance of tumor cells to chemo- and radiotherapy; DNA-PK plays a key role in the NHEJ pathway and DSB repair."}]