[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C@H1][Branch2][Ring1][O][C][=N][N][=C][N][Ring1][Branch1][C][=C][Branch1][=Branch1][C][=C][Ring1][=Branch1][F][C][=C][N][Branch1][Branch1][N][=C][Ring1][Branch1][C][N][C][=C][C][=C][Branch1][Branch1][C][Ring1][=Branch1][=O][C][=C][Branch1][Branch1][C][=N][Ring1][Branch2][O][C][C][O][C]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis."}]