[{"from": "human", "value": "Please give me some details about this molecule. [C][C@@H1][Branch2][Branch1][O][C@H1][Branch2][Ring1][=Branch1][O][C@H1][Ring1][Branch1][N][C][=N][C][=C][Ring1][Branch1][N][=C][Branch1][=Branch1][N][C][Ring1][=Branch1][=O][N][C][O][P][=Branch1][C][=O][Branch1][C][O][O][C@H1][C][C@@H1][Branch1][#Branch1][O][C@@H1][Ring1][Branch1][C][O][N][C][=N][C][=Branch1][=Branch1][=N][C][Ring1][=Branch1][=O][N][O]"}, {"from": "gpt", "value": "The molecule is a dinucleotide antimetabolite composed of a decitabine linked via phosphodiester bond to a deoxyguanosine, with potential antineoplastic activity. Following metabolic activation via cleavage of the phosphodiester bond and incorporation of the decitabine moiety into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing non-specific, genome-wide hypomethylation, and induction of cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, which may result in gradual release of decitabine both extra- and intra-cellularly, leading to prolonged exposure to decitabine."}]