[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][=C][C][=C][Branch1][S][C][=C][Ring1][=Branch1][C][=C][N][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][18F][N][C][=C][Ring1][=C][C][=N][C][=C][Ring1][=Branch1]"}, {"from": "gpt", "value": "The molecule is a radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration,  flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI)."}]