[{"from": "human", "value": "Provide a description of this molecule. [C][C][C@H1][C][=Branch1][C][=O][N][Branch2][N][Ring1][C][C][=Branch1][C][=O][N][Branch2][O][=Branch2][C@H1][Branch2][#Branch2][#C][C][=Branch1][C][=O][N][C@H1][Branch2][=Branch2][P][C][=Branch1][C][=O][N][Branch2][=Branch2][Branch2][C@H1][Branch2][Branch2][=C][C][=Branch1][C][=O][N][C@H1][Branch2][Branch2][Ring2][C][=Branch1][C][=O][N][C@@H1][Branch2][#Branch1][#Branch2][C][=Branch1][C][=O][N][Branch2][=Branch1][P][C@H1][Branch2][=Branch1][#Branch1][C][=Branch1][C][=O][N][Branch2][Branch1][=C][C@H1][Branch2][Branch1][Ring2][C][=Branch1][C][=O][N][Branch2][Ring2][O][C@H1][Branch2][Ring2][C][C][=Branch1][C][=O][N][Branch2][Ring1][=Branch2][C@H1][Branch1][=Branch2][C][=Branch1][C][=O][N][Ring2][Ring2][N][C@@H1][Branch1][#Branch2][C@H1][Branch1][C][C][C][/C][=C][/C][=C][O][C][C][Branch1][C][C][C][C][C][C][Branch1][C][C][C][C][C][C][Branch1][C][C][C][C][C][C][C][C][Branch1][C][C][C][C][C][Branch1][C][C][C][C][C][Branch1][C][C][C][C][C]"}, {"from": "gpt", "value": "The molecule is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus (SLE).  LN is a significant cause of renal failure,  morbidity, and death in patients with SLE. Within 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. Early and accurate intervention for LN is important in improving clinical outcomes.    Voclosporin, marketed as Lupkynis, is a calcineurin-inhibitor immunosuppressant for the treatment of LN. This [cyclosporine] A analog was approved by the FDA on January 22, 2021 following promising results in clinical trials. Early intervention with voclosporin coupled with a kidney response is believed to prevent irreversible damage to the kidney and lead to better long-term clinical outcomes for patients with LN. Voclosporin has demonstrated a more stable pharmacokinetic and pharmacodynamic relationship than cyclosporine, a higher potency than cyclosporine, and an improved metabolic profile when compared to older calcineurin inhibitors.  In July 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended voclosporin be granted marketing authorization for use in combination with [mycophenolate mofetil] for the treatment of adult patients with active lupus nephritis."}]