[{"from": "human", "value": "Please give me some details about this molecule. [C][C@][C][C][C][=Branch1][C][=O][C][=C][Ring1][#Branch1][C][C][C@@H1][C@@][Ring1][O][Branch2][Ring1][=N][C@H1][Branch2][Ring1][Branch2][C][C@][Branch2][Ring1][C][C@H1][Ring1][=Branch1][C][C][C@@][Ring1][Branch1][Branch1][#Branch1][C][=Branch1][C][=O][C][O][O][C][O][F]"}, {"from": "gpt", "value": "The molecule is a synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion."}]