[{"from": "human", "value": "What can you tell me about this molecule? [C][C][Branch1][C][C][C@H1][Branch1][=Branch1][C][=Branch1][C][=O][N][N][C][=Branch1][C][=O][O][C@@H1][C][C][C@][Branch1][Branch1][C][O][Ring1][Ring1][C@H1][Branch1][=Branch1][C@@H1][Ring1][Branch2][O][C][C@@][Branch1][=C][C@H1][Branch1][Ring2][O][Ring1][Ring1][C][C][=C][Branch1][C][C][C][C]"}, {"from": "gpt", "value": "The molecule is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties.  PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04)"}]