[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][C][=Branch2][Ring2][=Branch1][=C][C][=Branch2][Ring1][S][=C][Ring1][=Branch1][O][C][=N][C][=Branch1][#Branch2][=N][C][=Branch1][Branch1][=C][Ring1][=Branch1][Br][N][N][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][#N][C][C][#N]"}, {"from": "gpt", "value": "The molecule is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT."}]