[{"from": "human", "value": "What can you tell me about this molecule? [C][C@H1][C][C@@H1][Branch2][Branch2][=Branch1][C@@H1][Branch2][#Branch1][P][C@H1][Branch2][#Branch1][N][/C][=C][Branch2][#Branch1][=Branch1][/C@@H1][Branch2][=Branch1][N][C@H1][Branch2][=Branch1][=Branch1][/C][=C][\\C][=C][Branch2][Branch1][=C][\\C][=Branch1][C][=O][N][C][=C][C][=Branch1][C][=O][C][=Branch1][N][=C][Branch1][Branch1][C][Ring2][Ring1][#Branch1][C][Ring1][Branch2][=O][N][C][C][C][C][C][C][P+1][Branch1][=Branch2][C][=C][C][=C][C][=C][Ring1][=Branch1][Branch1][=Branch2][C][=C][C][=C][C][=C][Ring1][=Branch1][C][=C][C][=C][C][=C][Ring1][=Branch1][/C][O][C][O][C][=Branch1][C][=O][N][\\C][C][O][O][C]"}, {"from": "gpt", "value": "The molecule is a resorcinolic-based mitochondrial-targeted heat shock protein 90 (Hsp90) family inhibitor, with potential antineoplastic activity. Upon administration, gamitrinib targets and inhibits the activity of Hsp90 heat shock proteins, such as TNF receptor-associated protein-1 (TRAP1). This induces the accumulation of the mitochondrial kinase PINK1 and the cytosolic E3 ubiquitin (Ub) ligase Parkin, ubiquitylates substrate proteins, and induces PINK1/Parkin-dependent mitophagy. Gamitrinib induces acute mitochondrial dysfunction, loss of membrane potential and membrane rupture leading to the induction of apoptosis in susceptible tumor cells. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins."}]