[{"from": "human", "value": "Please give me some details about this molecule. [C][C@H1][Branch2][Ring2][=Branch1][C][=C][C][=Branch2][Ring1][#Branch1][=C][C][=C][Ring1][=Branch1][O][C][=Branch1][=Branch1][=C][C][Ring1][=Branch1][=O][N][C][C][O][C][C][Ring1][=Branch1][C][=Branch1][C][=O][N][Branch1][C][C][C][N][C][=C][C][=Branch1][=Branch2][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][F][F]"}, {"from": "gpt", "value": "The molecule is an inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation and induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents."}]