[{"from": "human", "value": "Provide a description of this molecule. [C][C@H1][C][C][C][C@@H1][C@@H1][Branch2][=Branch2][N][N][Ring1][Ring1][C][C][O][C][=Branch1][C][=O][O][C][C][S][S][C][C@@H1][Branch1][=Branch1][C][=Branch1][C][=O][O][N][C][=Branch1][C][=O][C@H1][Branch1][#Branch1][C][C][=Branch1][C][=O][O][N][C][=Branch1][C][=O][C@H1][Branch1][#Branch2][C][C][C][N][=C][Branch1][C][N][N][N][C][=Branch1][C][=O][C@H1][Branch1][#Branch1][C][C][=Branch1][C][=O][O][N][C][=Branch1][C][=O][C][C][C@@H1][Branch1][=Branch1][C][=Branch1][C][=O][O][N][C][=Branch1][C][=O][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][C][C][=C][N][=C][C][=Branch1][Ring2][=N][Ring1][=Branch1][C][=Branch1][C][=O][N][C][=Branch1][Ring2][=N][Ring1][Branch2][N][C][C@H1][Branch2][Ring1][S][O][C][=Branch1][C][=O][C][C@@H1][Branch2][Ring1][Branch1][C][Branch1][=C][C][=Branch1][C][=O][C@@H1][Branch1][=Branch1][C@H1][Ring2][#Branch1][=N][O][C][Branch1][C][C][C][O][/C][=Branch1][N][=C][/C][=C][S][C][=Branch1][Ring2][=N][Ring1][Branch1][C][/C]"}, {"from": "gpt", "value": "The molecule has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target folate receptor expressing cancer cells. In Phase I/IIa pharmacokinetic and safety studies epofolate was generally tolerable and toxicities known to be associated with epothilone class of anticancer agents were common, although peripheral neuropathy and neutropenia appear to have been less frequent and less severe as compared to epothilones. Antitumor activity was not demonstrated and further development of BMS-753493 has been discontinued."}]