[{"from": "human", "value": "Please give me some details about this molecule. [C][C@@H1][Branch2][Ring1][=Branch1][C@H1][Branch1][P][S][C@H1][Ring1][Branch1][N][C][=N][C][=Branch1][=Branch1][=N][C][Ring1][=Branch1][=O][N][C][O][O]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation."}]