[{"from": "human", "value": "What can you tell me about this molecule? [C][O][C][=C][Branch2][Ring2][Branch1][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][S][=Branch1][C][=O][=Branch1][C][=O][/C][=C][/C][=C][Branch1][=N][C][=C][Branch1][#Branch1][C][=C][Ring1][=Branch1][O][C][O][C][O][C][O][P][=Branch1][C][=O][Branch1][C][O][O]"}, {"from": "gpt", "value": "The molecule is a benzyl styryl sulfone analog, and a phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. suppresses cyclin D1 accumulation in cancer cells."}]