[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C@@H1][C][C@H1][C@@H1][C][C][C][=C][C][=Branch1][C][=O][C][=C][C@@][Ring1][#Branch1][Branch2][Ring1][P][C@][Ring1][O][Branch2][Ring1][#Branch2][C@H1][Branch2][Ring1][Branch1][C][C@@][Ring1][#C][Branch1][=C][C@][Ring2][Ring1][C][Branch1][#Branch1][C][=Branch1][C][=O][C][O][O][C][O][F][C]"}, {"from": "gpt", "value": "The molecule is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone].  Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen."}]