[{"from": "human", "value": "Describe this molecule. [C][C][PH1+1][Branch1][Ring1][C][C][C][C].[C][C][=Branch1][C][=O][O][C][C][C][Branch2][Ring1][#Branch2][C][Branch1][P][C][Branch1][Branch2][C][Branch1][Ring2][O][Ring1][=Branch1][S-1][O][C][=Branch1][C][=O][C][O][C][=Branch1][C][=O][C][O][C][=Branch1][C][=O][C].[Au+1]"}, {"from": "gpt", "value": "The molecule is an orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis."}]