[{"from": "human", "value": "What can you tell me about this molecule? [C][N][C][=N][C][=Branch2][Ring1][C][=C][Ring1][Branch1][S][C][=N][C][=N][C][=C][Ring1][=Branch1][N][C][=N][Ring1][Branch1][N+1][=Branch1][C][=O][O-1]"}, {"from": "gpt", "value": "The molecule is a purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes."}]