[{"from": "human", "value": "Provide a brief overview of this molecule. [C][N][C][C][=Branch1][C][=O][N][C@@H1][Branch1][Branch1][C][Ring1][#Branch1][=O][C][C][=C][Branch2][Ring1][Ring1][C@H1][Ring1][Branch2][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][O][C][O][Ring1][#Branch1][N][C][=C][C][=C][C][=C][Ring2][Ring1][Ring1][Ring1][=Branch1]"}, {"from": "gpt", "value": "The molecule is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy. It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and a longer half-life which has made it a more suitable option for chronic once-daily dosing in the treatment of PAH."}]