[{"from": "human", "value": "Describe this molecule. [C][N][C][C][C][C][C][O][C][=C][Branch2][Ring2][Ring1][C][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][C][=Branch1][=Branch1][=N][C][=N][Ring1][#Branch1][N][C][=C][Branch1][Branch1][C][Ring2][Ring1][Branch1][C][=C][C][=Branch1][Ring2][=C][Ring1][#Branch1][Br][O][C]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB)."}]