[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][C][=C][Branch1][=N][C][=Branch1][=Branch2][=N][C][=Branch1][Ring2][=N][Ring1][=Branch1][N][N][C][=C][C][=Branch1][O][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][=N+1][=N-1][Cl]"}, {"from": "gpt", "value": "The molecule is an antifolate derived from diaminopyrimidine with cytotoxic properties.  With a mechanism of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. This agent is more lipophilic but less potent than MTX. (NCI04)"}]