[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][C][C@@H1][Branch2][Ring1][P][C][=Branch1][C][=O][N][C][=C][N][Branch1][Branch1][C][=N][Ring1][Branch1][C][Branch1][C][C][Branch1][C][C][C][N][C][C][Branch1][C][C][Branch1][C][C][C][N][C@H1][C][C][C][=C][Branch1][Ring2][C][Ring1][=Branch1][C][=Branch1][=Branch2][=C][C][=Branch1][Ring2][=C][Ring1][#Branch1][F][F]"}, {"from": "gpt", "value": "The molecule is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival."}]