[{"from": "human", "value": "Describe this molecule. [C][C][=N][C][=C][Branch2][Ring1][=Branch2][N][=C][Branch1][=N][N][=C][Ring1][=Branch1][N][Ring1][=Branch2][C][Branch1][C][C][C][N][C][C][O][C][C][Ring1][=Branch1][C][=C][N][=C][Branch1][Branch1][N][=C][Ring1][=Branch1][N]"}, {"from": "gpt", "value": "The molecule is a potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR is a serine/threonine kinase downstream of PI3K, which also has PI3K-independent activity. Consequently, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase."}]