[{"from": "human", "value": "Provide a brief overview of this molecule. [C][N][C][C][N][Branch1][Branch1][C][C][Ring1][=Branch1][C][=C][N][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][C][=N][C][=C][C][=C][C][=Branch1][C][=O][N][C][C][Branch1][#Branch2][N][Ring1][#Branch1][C][Ring1][#Branch2][=N][Ring1][=C][C][C][C][C][C][Ring1][=Branch2]"}, {"from": "gpt", "value": "The molecule is a CDK4 and CDK6 inhibitor, indicated to reduce the incidence of chemotherapy induced myelosuppression in patients before topotecan-containing or platinum and etoposide-containing chemotherapy for extensive stage small cell lung cancer. CDK4 and CDK6 inhibitors have been investigated since the mid 1990s for their use in tumorigenesis and chemotherapy. Trilaciclib was first described in the literature in 2016.  Trilaciclib was granted FDA approval on 12 February 2021."}]