[{"from": "human", "value": "Could you provide a description of this molecule? [C][C@H1][Branch1][#Branch2][O][C@H1][Branch1][Ring2][S][Ring1][Branch1][C][O][N][C][=C][C][=Branch1][=Branch1][=N][C][Ring1][=Branch1][=O][N]"}, {"from": "gpt", "value": "The molecule is a synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP).  In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA.  In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)"}]