[{"from": "human", "value": "Please give me some details about this molecule. [C][C@@H1][C][C@H1][C@@H1][C][C@@H1][Branch2][Branch1][=N][C][=C][C][=Branch1][C][=O][C][=C][C@@][Ring1][#Branch1][Branch2][Ring2][=C][C@][Ring1][O][Branch2][Ring2][#Branch1][C@H1][Branch2][Ring2][C][C][C@@][Ring1][#C][Branch2][Ring1][#Branch2][C@][Ring2][Ring1][C][Branch1][Branch2][C][=Branch1][C][=O][S][C][F][O][C][=Branch1][C][=O][C][=C][C][=C][O][Ring1][Branch1][C][O][F][C][F]"}, {"from": "gpt", "value": "The molecule is the furoate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with anti-allergic, anti-inflammatory and anti-pruritic effects. Upon administration, fluticasone binds to and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2 and the cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, which leads to dephosphorylation and inactivation of Jun N-terminal kinase and directly inhibits c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibiting the transcription of cyclooxygenase 2 (COX-2), which is essential for prostaglandin production."}]