[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C][C][C][Branch1][Branch1][C][C][Ring1][=Branch1][N][C][C][C][N][C][C][C][C][C][Branch1][Branch1][C][C][Ring1][=Branch1][C][N][C][=N][C][=Branch2][Ring1][N][=C][C][=Branch1][Ring2][=N][Ring1][=Branch1][N][C][C][N][Branch1][Branch1][C][C][Ring1][=Branch1][C][C][P][=Branch1][C][=O][Branch1][C][O][O][N]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow."}]