[{"from": "human", "value": "Could you provide a description of this molecule? [C][C][=C][C][=C][Branch2][Ring2][=Branch1][C][=C][C][=C][Ring1][=Branch1][N][Ring1][=Branch2][C][=N][C][=C][Branch1][#Branch1][C][O][C][C][Ring1][=Branch1][C][=Branch1][Ring2][=N][Ring1][#Branch2][N][C][C][=C][C][=C][C][=C][Ring1][=Branch1][C][=Branch1][C][=O][N]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of valosin-containing protein (VCP) p97, with potential antineoplastic activity. Upon oral administration, CB-5083 specifically binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent stress response pathway, and leads to both an induction of apoptosis and inhibition of cell proliferation in susceptible tumor cells. p97, a type II AAA ATPase, plays a key role in cellular protein homeostasis. Its overexpression in many tumor cell types is associated with increased tumor cell proliferation and survival."}]