[{"from": "human", "value": "What can you tell me about this molecule? [C][C][=C][C][=C][Branch2][#Branch1][#C][C@@H1][C@@H1][C@H1][C][=C][Branch2][=Branch1][P][C][=Branch2][=Branch1][N][=C][C][=Branch2][Branch1][P][=C][Ring1][=Branch1][C@@H1][Branch2][Ring1][C][N][Ring1][#Branch2][C@H1][Branch1][O][C@H1][Branch1][Ring2][C][Ring1][S][N][Ring1][#C][C][O][C][O][C][=Branch1][C][=O][C@@][Branch1][=Branch1][C][S][Ring2][Ring1][=Branch1][C][=C][Branch1][=Branch1][C][C][N][Ring1][Branch2][C][=C][Branch1][Ring2][N][Ring1][Branch2][C][=C][C][=Branch1][Ring2][=C][Ring1][#Branch1][O][C][O][C][O][Ring2][Ring2][Ring1][C][O][C][=Branch1][C][=O][C][C][=Branch1][#Branch1][=C][Ring2][Branch1][Ring2][O][C][O]"}, {"from": "gpt", "value": "The molecule is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent found in extracts of the tunicate Ecteinascidia turbinata, with the primary difference being the substitution of the tetrahydroisoquinoline with a tetrahydro \u03b2\u2010carboline that results in increased antitumour activity of lurbinectedin as compared to its predecessor.  On June 15, 2020, the FDA granted accelerated approval and orphan drug designation to lurbinectedin for the treatment of adult patients with metastatic SCLC who have experienced disease progression despite therapy with platinum-based agents. This accelerated approval is based on the rate and duration of therapeutic response observed in ongoing clinical trials and is contingent on the verification of these results in confirmatory trials."}]