[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][N][=C][Branch1][Branch1][C][=N][Ring1][=Branch1][C][N][C][=Branch1][C][=O][C][=C][N][Branch1][N][C][=C][C][=C][C][=C][Ring1][=Branch1][S][Ring1][=Branch2][C][=C][Branch1][Branch1][C][Ring1][=N][=O][C][=C][C][=Branch1][Ring2][=N][Ring1][Branch2][N][C][C][C][N][Branch1][Branch1][C][C][Ring1][#Branch1][C]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of RNA polymerase I (Pol I), with potential antineoplastic activity. Upon oral administration, pidnarulex selectively binds to and inhibits Pol I, prevents Pol I-mediated ribosomal RNA (rRNA) synthesis, induces apoptosis, and inhibits tumor cell growth. Pol I, the multiprotein complex that synthesizes rRNA, is upregulated in cancer cells and plays a key role in cell proliferation and survival. Hyperactivated rRNA transcription is associated with uncontrolled cancer cell proliferation."}]