[{"from": "human", "value": "Please give me some details about this molecule. [C][C@][C][C][C@H1][Branch2][Ring1][=C][C][C@@H1][Ring1][=Branch1][C][C][C@@H1][C@@H1][Ring1][#Branch2][C][C][C@][Branch1][=C][C@H1][Ring1][=Branch1][C][C][C@][Ring1][Branch1][Branch1][Ring1][C][#C][O][C][O]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2."}]