[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C][C@@H1][Branch1][#Branch1][O][C@@H1][Ring1][Branch1][C][O][N][C][=N][C][=C][Ring1][Branch1][N][=C][N][C][Ring1][=Branch1][=O]"}, {"from": "gpt", "value": "The molecule is a purine nucleoside analogue and reverse transcriptase inhibitor that was previously widely used in combination with other agents in the therapy of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndromes (AIDS). Didanosine therapy is associated with an appreciable rate of serum enzyme elevations during therapy, and it is a well established cause of clinically apparent acute liver injury as well as mitochondrial injury to many organs which can be associated with severe liver injury, lactic acidosis and hepatic failure. Finally, long term therapy with didanosine can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia. Because of its many, potentially severe adverse events, didanosine has been largely replaced by better tolerated agents and is now rarely used."}]