[{"from": "human", "value": "Please give me some details about this molecule. [C][C@@H1][C][O][C][C][N][Ring1][=Branch1][C][=N][C][=C][Branch1][=C][C][=C][N][=C][Ring1][=Branch1][C][=C][C][=N][N][Ring1][Branch1][C][=Branch1][Ring2][=C][Ring1][#C][C][=C][C][=N][N][Ring1][Branch1][C]"}, {"from": "gpt", "value": "The molecule is an orally available ataxia telangiectasia and Rad3-related (ATR)-specific kinase inhibitor, with potential antineoplastic activity. Upon oral administration, elimusertib selectively binds to and inhibits the activity of ATR, which prevents ATR-mediated signaling. This inhibits DNA damage checkpoint activation, disrupts DNA damage repair and induces apoptosis in ATR-overexpressing tumor cells. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and cell survival."}]