[{"from": "human", "value": "Please give me some details about this molecule. [C][/C][=C][Branch1][C][/C][\\C][=Branch1][C][=O][O][C@H1][C][=Branch2][Ring2][=N][=C][C@@][C@@][Ring1][Branch1][Branch2][Ring2][Ring2][C@@H1][Branch2][Ring1][#C][C][=Branch2][Ring1][=Branch2][=C][C@H1][Branch1][Branch1][C][Ring1][#Branch1][=O][C@H1][C@H1][Branch1][Branch2][C][Ring1][Ring1][Branch1][C][C][C][C][C@H1][Ring1][#C][C][C][O][O][O][C]"}, {"from": "gpt", "value": "The molecule is marketed under the name Picato\u00ae. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and cancer. PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations."}]