[{"from": "human", "value": "Please give me some details about this molecule. [C][N][C][=Branch1][=Branch1][=N][C][=N][Ring1][Branch1][C@@H1][C@H1][Branch2][Ring1][=Branch1][N][C][=C][C][=Branch1][#C][=C][C][=C][Ring1][=Branch1][C][Ring1][#Branch2][=N][N][C][Ring1][=Branch1][=O][F][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][F]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks."}]