[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][N][=C][Branch1][=Branch2][C][=Branch1][Ring2][=N][Ring1][=Branch1][O][C][N][S][=Branch1][C][=O][=Branch1][C][=O][C][=C][Branch1][#Branch1][N][=C][C][=C][Ring1][=Branch1][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][=N][N][=C][O][Ring1][Branch1]"}, {"from": "gpt", "value": "The molecule is an orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation."}]