[{"from": "human", "value": "Provide a brief overview of this molecule. [C][O][C][=C][Branch2][Ring2][Ring1][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][C@H1][Branch2][Ring1][Branch1][C][=C][C][=Branch1][=C][=C][Branch1][=Branch2][C][=Branch1][Ring2][=C][Ring1][=Branch1][O][C][O][C][O][C][O][O]"}, {"from": "gpt", "value": "The molecule is a stilbenoid phenol, originally isolated from the bark of the African bush willow tree Combretum caffrum, with vascular disrupting and antineoplastic activities. Combretastatin targets and binds to the colchicine-binding site of tubulin, thereby impairs the polymerization of tubulin dimers and prevents the formation of microtubules in the endothelial cells of tumor. As a result, this may eventually lead to a destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis."}]