[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][Branch1][=Branch1][C][=N][N][Ring1][Branch1][C][=C][C][=C][Branch1][Ring2][S][Ring1][Branch1][C][=Branch1][C][=O][N][C][=Branch1][Ring2][=N][Ring1][Branch2][C@@H1][C][C][C][C][N][Ring1][=Branch1][C][C][Ring1][=Branch1]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of cell division cycle 7 (cell division cycle 7-related protein kinase; CDC7), with potential antineoplastic activity. Upon administration, simurosertib binds to and inhibits CDC7; this prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis. This inhibits cell growth in CDC7-overexpressing tumor cells. CDC7, a serine/threonine kinase and cell division cycle protein, is overexpressed in a variety of cancers and plays a key role in the activation of DNA replication and the regulation of cell cycle progression."}]