[{"from": "human", "value": "Provide a brief overview of this molecule. [C][O][C][=C][Branch1][=Branch1][S][C][=C][Ring1][Branch1][C][N][C][C][C@][Branch1][S][C][C][O][C][Branch1][Ring2][C][Ring1][=Branch1][C][C][C][C][Ring1][=Branch1][C][=C][C][=C][C][=N][Ring1][=Branch1]"}, {"from": "gpt", "value": "The molecule is mediated in part by the action of opioid receptors. Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the \u03bc-opioid receptor subtype is predominantly targeted by and is responsible for the effects of opioid agonists. However, due to the ability of some opioid agonists to bind to other targets, as well as activation of additional downstream pathways from opioid receptors such as those involving \u03b2-arrestin, the beneficial analgesic effects of opioids are coupled with severe adverse effects such as constipation and respiratory depression.  Oliceridine (formerly known as TRV130) is a \"biased agonist\" at the \u03bc-opioid receptor by preferentially activating the G-protein pathway with minimal receptor phosphorylation and recruitment of \u03b2-arrestin. By acting as a biased agonist, oliceridine provides comparable analgesia compared with traditional opioids such as [morphine] at a comparable or decreased risk of opioid-related adverse effects such as constipation and respiratory depression.  Oliceridine was first reported in 2013, but was initially not approved by the FDA due to concerns raised by the Anesthetic and Analgesic Drug Products Advisory Committee. Oliceridine gained FDA approval on August 7, 2020, and is currently marketed by Trevena Inc as OLINVYK\u2122."}]