[{"from": "human", "value": "Could you provide a description of this molecule? [C][C][C@H1][Branch1][=Branch1][C][N][C][Ring1][=Branch1][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][C][=C][C][=C][C][=C][Branch1][#Branch1][C][Ring1][=Branch1][=N][Ring1][=Branch2][C][=Branch1][C][=O][N]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks."}]