[{"from": "human", "value": "Please give me some details about this molecule. [C][C][=C][Branch2][Branch1][C][C][=C][Branch2][Ring1][#C][C][=C][Ring1][=Branch1][N][C][C][N][Branch1][Branch1][C][C][Ring1][=Branch1][C][=N][C][=N][C][=N][N][C][=Branch1][=Branch1][=C][Ring1][Branch1][Ring1][=Branch2][Br][C][=Branch1][C][=O][C][C][C][Branch1][C][F][Branch1][C][F][F][N][C][C][N][C][C][C][C][Ring1][Branch1]"}, {"from": "gpt", "value": "The molecule is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells."}]