[{"from": "human", "value": "Please give me some details about this molecule. [C][C][=Branch1][C][=O][O][C][C][=Branch1][C][=O][C@][Branch2][Ring2][=Branch2][C][C][C@@H1][C@@][Ring1][Branch1][Branch2][Ring1][#C][C][C@@H1][Branch2][Ring1][=Branch2][C@][Branch2][Ring1][Ring2][C@H1][Ring1][=Branch1][C][C][C][=C][C][=Branch1][C][=O][C][C][C@@][Ring1][#Branch1][Ring1][O][C][F][O][C][O]"}, {"from": "gpt", "value": "The molecule is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney."}]