[{"from": "human", "value": "Provide a description of this molecule. [C][C][Branch1][C][C][Branch2][Ring2][#C][C][C][C][C][Branch1][Branch1][C][C][Ring1][=Branch1][N][C][=N][N][C][=Branch2][Ring1][Branch2][=N][C][=C][Ring1][Branch1][C][=C][C][=Branch1][=Branch1][=C][C][=C][Ring1][=Branch1][C][Branch1][C][F][Branch1][C][F][F][C][=C][Ring2][Ring1][Ring1][O]"}, {"from": "gpt", "value": "The molecule is an orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival."}]