[{"from": "human", "value": "What can you tell me about this molecule? [C][=Branch1][=C][=N][C][=Branch1][C][=O][N][C][=Branch1][C][=O][N][Ring1][Branch2][C][=Branch1][C][=O][O]"}, {"from": "gpt", "value": "The molecule is a modulator of 5-fluorouracil (5-FU) activity and inhibitor of the enzyme orotate phosphoribosyl-transferase (OPRT), with chemoprotective activity. Oteracil preferentially localizes in the gastrointestinal (GI) tract where it inhibits OPRT, thereby decreasing metabolism of 5-FU into its active metabolite 5-fluorouridine-5'-monophosphate (FUMP). This decreases activated 5-FU-related gastrointestinal toxicity."}]