[{"from": "human", "value": "Describe this molecule. [C][C][C][N][S][=Branch1][C][=O][=Branch1][C][=O][N][C][=C][Branch2][Ring1][Branch2][C][=Branch1][=Branch1][=N][C][=N][Ring1][=Branch1][O][C][C][O][C][=N][C][=C][Branch1][Branch1][C][=N][Ring1][=Branch1][Br][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][Br]"}, {"from": "gpt", "value": "The molecule is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types."}]