[{"from": "human", "value": "What can you tell me about this molecule? [C][N][C][=N][C][=C][Ring1][Branch1][C@@][Branch1][N][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][Cl][Branch2][Ring2][Ring1][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][Branch2][Ring1][Ring2][C][=Branch1][C][=O][C][=C][Ring1][=Branch2][C][=C][C][=Branch1][=Branch1][=C][C][=C][Ring1][=Branch1][Cl][C][N]"}, {"from": "gpt", "value": "The molecule is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction.  By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)"}]