[{"from": "human", "value": "What can you tell me about this molecule? [C][C@@H1][C@@H1][C@H1][Branch2][Ring2][Branch2][C][=Branch1][C][=O][N][Ring1][Branch1][C][=Branch2][Ring1][Branch2][=C][Ring1][Branch2][S][C@H1][C][C@H1][Branch1][Branch1][N][C][Ring1][Branch1][C][N][S][=Branch1][C][=O][=Branch1][C][=O][N][C][=Branch1][C][=O][O][C@@H1][Branch1][C][C][O]"}, {"from": "gpt", "value": "The molecule is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that doripenem carried an increased risk of death and lower clinical cure rates, resulting in a premature termination of the trial. The FDA revised the doripenem label in 2014 to include a warning against use in ventilator-associated pneumonia and to reiterate its safety and efficacy for its approved indications."}]