[{"from": "human", "value": "Could you provide a description of this molecule? [C][C@H1][Branch2][Ring1][Ring1][C][N][C][=C][Ring1][=Branch1][C][=Branch1][C][=O][N][C][=Branch1][Ring2][=N][Ring1][#Branch1][N][C][C][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][=Branch1][C][=O][N][C@@H1][Branch1][Branch2][C][C][C][=Branch1][C][=O][O][C][=Branch1][C][=O][O]"}, {"from": "gpt", "value": "The molecule is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.  The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. (NCI04)"}]