[{"from": "human", "value": "Please give me some details about this molecule. [C][=C][C][=Branch2][Ring2][Ring2][=C][Branch2][Ring1][#C][C][=C][Ring1][=Branch1][N][=C][Branch2][Ring1][Ring2][C][=N][O][N][=C][Ring1][Branch1][N][C][C][N][S][=Branch1][C][=O][=Branch1][C][=O][N][N][O][Br][F]"}, {"from": "gpt", "value": "The molecule is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. Epacadostat targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and DCs."}]