[{"from": "human", "value": "Provide a brief overview of this molecule. [C][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][S][=Branch1][C][=O][=Branch1][C][=O][O].[C][C][=C][Branch1][=Branch1][S][C][=C][Ring1][Branch1][C][=Branch1][C][=O][N][C][=C][Branch2][Ring1][#Branch2][C][=C][C][=Branch1][Ring2][=C][Ring1][=Branch1][C][N][C][C][N][Branch1][Branch1][C][C][Ring1][=Branch1][C][=Branch1][C][=O][C][O][/C][=C][/C][=N][N][C][=C][C][=C][C][=C][Ring1][=Branch1][Ring1][=Branch2]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis."}]