[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C][=Branch2][Ring2][N][=C][C][C@@H1][C@@][Branch1][Ring2][O][Ring1][Ring1][Branch1][C][C][C@H1][C@@H1][Branch2][Ring1][=Branch2][C@@H1][Branch1][#Branch2][C][C][C@][Ring1][=Branch1][C][O][Ring1][Ring1][O][C][=Branch1][C][=O][N][C][=Branch1][C][=O][C][Cl][O][C][C]"}, {"from": "gpt", "value": "The molecule is a synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity.  TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis.  This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04)"}]