[{"from": "human", "value": "Describe this molecule. [C][C][=C][C][=C][Branch2][#Branch1][=Branch2][C@@H1][C@@H1][C@H1][C][=C][Branch2][=Branch1][O][C][=Branch2][=Branch1][=Branch1][=C][C][=Branch2][Branch1][O][=C][Ring1][=Branch1][C@@H1][Branch2][Ring1][C][N][Ring1][#Branch2][C@H1][Branch1][O][C@H1][Branch1][Ring2][C][Ring1][S][N][Ring1][#C][C][O][C][O][C][=Branch1][C][=O][C@@][Branch1][=Branch1][C][S][Ring2][Ring1][=Branch1][C][=C][C][=Branch1][=C][=C][Branch1][#Branch2][C][=C][Ring1][=Branch1][C][C][N][Ring1][N][O][O][C][O][C][O][Ring2][Ring1][P][C][O][C][=Branch1][C][=O][C][C][=Branch1][#Branch1][=C][Ring2][Branch1][C][O][C][O]"}, {"from": "gpt", "value": "The molecule is a marine-derived antitumor agent discovered in the Carribean tunicate Ecteinascidia turbinata and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas."}]