[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C][=C][Branch2][Branch1][Ring2][C][=C][Branch2][Ring2][=Branch1][C][C][C][Branch1][Ring2][O][Ring1][=Branch1][Branch1][C][C][C][O][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][C][C][=Branch1][C][=O][N][C][=Branch1][C][=O][S][Ring1][#Branch1][C][=Branch1][=Branch1][=C][Ring2][Ring1][O][O][C][C]"}, {"from": "gpt", "value": "The molecule is an orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity.  Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis.  This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)"}]