[{"from": "human", "value": "What can you tell me about this molecule? [C][C][Branch1][Branch2][C][C][C][C][C][Ring1][=Branch1][C][O][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][C][C][=Branch1][C][=O][N][C][=Branch1][C][=O][S][Ring1][#Branch1]"}, {"from": "gpt", "value": "The molecule is considered the prototypical compound for the thiazolidinedione class.  Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were later developed, some of which\u2014such as pioglitazone and troglitazone\u2014made it to the market.  Ciglitazone significantly decreases VEGF production by human granulosa cells in an in vitro study, and may potentially be used in ovarian hyperstimulation syndrome. Ciglitazone is a potent and selective PPAR\u03b3 ligand with an EC50 of 3.0 \u00b5M. It is also an anti-hyperglycemic agent in the ob/ob murine model in vivo. Ciglitazone increases adipogenesis, decreases differentiation and angiogenesis in human umbilical vein endothelial cell (HUVEC), and osteoblastogenesis in human mesenchymal stem cells."}]