[{"from": "human", "value": "What can you tell me about this molecule? [C][=C][C][=N][C][=Branch1][Ring2][=C][Ring1][=Branch1][O][C][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][C][=N][O][C][=Branch1][Ring2][=C][Ring1][Branch1][C][=C][Branch2][Ring1][Ring1][N+1][=Branch1][=Branch1][=C][C][=C][Ring1][=Branch1][C][O][P][=Branch1][C][=O][Branch1][C][O][O-1][N]"}, {"from": "gpt", "value": "The molecule is an orally available small molecule inhibitor of the Gwt1 fungal enzyme with potential antifungal activity. Upon administration, fosmanogepix, a N-phosphonooxymethyl prodrug, is rapidly and completely metabolized by systemic alkaline phosphatases to its active moiety, APX001A (E1210). The active prodrug targets Gwt1, a highly conserved inositol acylase which catalyzes an essential step in the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway. Inhibition of Gwt1 prevents localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth."}]