[{"from": "human", "value": "Could you give me a brief overview of this molecule? [C][C@@H1][Branch2][Ring1][=Branch1][C@H1][Branch1][P][O][C@H1][Ring1][Branch1][N][C][=C][Branch1][#Branch1][C][=N][C][Ring1][=Branch1][=O][I][C][O][O]"}, {"from": "gpt", "value": "The molecule is an orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine, with radiosensitizing activity. Upon oral administration, ropidoxuridine (IPdR) is efficiently converted to idoxuridine (IUdR) by a hepatic aldehyde oxidase. In turn, IUdR is incorporated into DNA during replication, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. Compared to IUdR, ropidoxuridine is associated with a lower toxicity profile and improved anti-tumor activity."}]