[{"from": "human", "value": "Provide a brief overview of this molecule. [C][Branch2][O][C][C][C][Branch2][#Branch2][Ring2][C][Branch2][=Branch2][#Branch1][C][Branch2][Branch2][#Branch2][C][Branch1][Ring2][O][Ring1][=Branch1][O][C][C][Branch2][#Branch1][Branch1][C][Branch2][=Branch1][#Branch1][O][C][Branch1][=N][C][Ring1][=Branch1][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][C][C][Branch2][Ring2][Branch2][C][Branch2][Ring1][O][C][Branch1][=C][O][C][Ring1][=Branch1][O][S][=Branch1][C][=O][=Branch1][C][=O][O][C][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][S][=Branch1][C][=O][=Branch1][C][=O][O][C][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][S][=Branch1][C][=O][=Branch1][C][=O][O][O][P][=Branch1][C][=O][Branch1][C][O][O]"}, {"from": "gpt", "value": "The molecule is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity. Muparfostat inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process. This agent may also bind with high affinity to the heparan sulfate-binding domains of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2, thereby reducing their functional activities and inhibiting VEGF and FGF stimulation of tumor angiogenesis. Increased heparanase activity has been implicated in tumor angiogenesis and metastasis."}]