[{"from": "human", "value": "Could you provide a description of this molecule? [C][C][=C][Branch1][N][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][C][N][C][N][C][=Branch1][C][=O][C][=C][C][=C][Branch1][Branch1][C][=C][Ring1][=Branch1][N][C][=N][C][=C][C][=C][C][=C][Ring1][=Branch1][C][=Branch1][Ring2][=N][Ring1][#Branch2][C][=C][C][=C][C][=C][Ring1][=Branch1].[C][S][=Branch1][C][=O][=Branch1][C][=O][O].[C][S][=Branch1][C][=O][=Branch1][C][=O][O].[O]"}, {"from": "gpt", "value": "The molecule is an orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO inhibitor BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway.  SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers."}]