[{"from": "human", "value": "What can you tell me about this molecule? [C][C][C][=C][C][=C][Branch2][Ring1][#Branch1][C][=C][Ring1][=Branch1][N][C][C][C][Branch1][Branch1][C][C][Ring1][=Branch1][N][C][C][O][C][C][Ring1][=Branch1][C][Branch2][Ring1][O][C][=C][Branch1][=Branch1][C][Ring2][Ring1][Ring2][=O][C][=C][Branch1][Ring2][N][Ring1][#Branch1][C][=C][Branch1][Branch1][C][=C][Ring1][#Branch1][C][#N][Branch1][C][C][C]"}, {"from": "gpt", "value": "The molecule is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting in reduced tumour cell viability.   Approved under accelerated approval in 2015, alectinib is indicated for use in patients who have progressed on or were not tolerant of crizotinib, which is associated with the development of resistance."}]