 The comparison is limited due to motion on the previous comparison study.Extensive confluent T2 hyperintensity is again evident within the periventricular white matter bilaterally and throughout the thinned corpus callosum. Extensive white matter signal abnormality is also evident within the midbrain, pons, bilateral middle cerebellar peduncles, and medulla. Most of these lesions seem not to have significantly changed, with the exception of an area of FLAIR hyperintensity in the posterior right parietal lobe white matter which appears to be new with associated enhancement along the posterior medial aspect of the lesion (47/11 and 801/52). There is also a ring enhancing lesion in the right frontal lobe (801/61). An additional enhancing punctate lesion is seen in the left corona radiata. Many of the lesions demonstrate T1 hypointensity.
Extensive white matter lesions consistent with known demyelinating disease, with a new area of FLAIR hyperintensity seen in the right parietal lobe white matter with minimal associated enhancement, consistent with a new area of demyelination. Additional enhancing lesions in the right frontal lobe and left corona radiata consistent with active plaques. Overall, moderate T1 and moderate-severe T2 burden of disease, including infratentorial lesions.