Reason: Chugai IRB- 14-0593 History: R/O PML prior to study The CSF spaces are appropriate for the patient's stated age with no midline shift. There is a mild degree of periventricular and to a greater degree subcortical punctate hyperintense white matter lesions present identified on the FLAIR and T2 images. Additionally there is a lesion present within the corpus callosum. Compared to the prior exam these remain stable.No abnormally enhancing lesions are appreciated within the brain parenchyma.Normal vascular flow voids are present in the distal carotid and vertebral arteries, the basilar artery and the proximal anterior, middle and posterior cerebral arteries as well as the internal cerebral veins and superior sagittal sinus.The visualized portions of the paranasal sinuses are clear. The visualized portions of the mastoid air cells are clear. The visualized portions of the orbits are intact.
There is redemonstration and no change in the subcortical, periventricular and corpus callosum white matter lesions. These are nonspecific but could be related to a demyelinating process.