Infant born at 30 weeks with concern for genetic anomaly; microcephaly, single nare, cannot open eyes: microcephaly, midface hypoplasia. There is fusion of the frontal lobes and thalami with a monoventricle, absence of the falx cerebri, no discernible corpus callosum or olfactory apparatus, and prominent posterior intracranial prominent cerebrospinal fluid space. There is diffuse absence of cerebral gyri and sulci, yielding a lissencephalic appearance. There is deficiency of myelination. The cerebellum is relatively intact. There is no evidence of intracranial hemorrhage, mass, or acute infarct. There is no midline shift or herniation. There is an azygous anterior cerebral artery. There is severe microcephaly and hypotelorism. There is a single blind-ended nostril associated with a tubular, proboscis-like appendage, just inferior to the level of the orbits. There is bilateral otomastoid fluid signal.
Findings compatible with alobar holoprosencephaly and cebocephaly.