### Human:\nmy father's legs are swollen from the knees down. he is taking cyclosporine. is this a side effect of the drug?\n\n### Assistant: there are many things that can cause swelling below the knee known as edema. it is usually a result of fluid retention and can be caused by several different health conditions. cyclosporine has been associated with causing edema in less than 2% of the people that take it. i suggest you contact the prescriber and notify him/her of your father's swelling. they can tell you how best to handle it considering his past medical history.