New device to monitor fetal heart development Feb. 25, 2013 - Technology developed at The University of Nottingham has been used in a breakthrough study aimed at developing the first comprehensive model of a fully functioning fetal heart. The abdominal fetal ECG device, designed originally by academics in the University's Department of Electrical and Electronic Engineering and on commercial sale throughout the world since 2008 through the University spin-out company Monica Healthcare Ltd, has been used to observe living fetal hearts of babies in their mothers' wombs. The collaborative study led by experts at The University of Leeds has discovered that the walls of the human heart are a disorganised jumble of tissue until relatively late in pregnancy -- with development much slower compared to other mammals. Professor Barrie Hayes-Gill, Professor of Electronic Systems and Medical Devices at The University of Nottingham and joint founder and research director at Monica Healthcare said: "It's absolutely fantastic to see our device being used to detect fetal ECG morphology (i.e. ECG shape) in a non-invasive manner from the surface of the maternal abdomen. In this study the Monica device has been specifically deployed to observe the development of the fetal heart as it goes through gestation. The fetal heart monitor is a portable, non-invasive device which attaches to the mother's abdomen and measures the electrical activity from the heart of the baby inside her womb. It is currently being used worldwide to monitor fetal heart rates during labour and delivery. The device uses complex algorithms to correctly identify signals related to the fetal heart rate (FHR) using sensitive ECG-style electrodes. This method of using electrophysiological signals differs from current external monitoring devices that collect FHR and uterine activity data based on physical changes (e.g. change in reflected sound waves and changes on strain gauge) that may cause problems in data interpretation. The monitor is simple to use, beltless, requires no wires to connect to the display or printer. There is also no need for the constant re-positioning of transducers, which is required with older technology and the mother is free to walk around if necessary. As part of their study, which has been published in the Journal of the Royal Society Interface Focus, the team from the University of Leeds used the device to administer a weekly fetal ECG recording from 18 weeks until just before delivery. The data from this, alongside two different MRI scans from the hearts of dead fetuses, was incorporated into a 3D computerised model built up using information about the structure, shape and size of the different components of the heart. Early results suggest that the human heart may develop on a different timeline from other mammals. While the tissue in the walls of a pig heart develops a highly organised structure at a relatively early stage of a fetus' development, their work suggests there is little organisation in the human heart's cells until 20 weeks into pregnancy. Despite this, the human heart has a regular heartbeat from about 22 days. Developing an accurate, computerised simulation of the fetal heart is critical to understanding normal heart developments in the womb and, eventually, to opening new ways of detecting and dealing with some functional abnormalities early in pregnancy. Dr Eleftheria Pervolaraki, lead researcher on the project at the University of Leeds' School of Biomedical Sciences, said: "For a heart to be beating effectively, we thought you needed a smoothly changing orientation of the muscle cells through the walls of the heart chambers. Professor Arun Holden, from The University of Leeds' School of Biomedical Sciences, said: "The development of the fetal human heart is on a totally different timeline, a slower timeline, from the model that was being used before. The above story is reprinted from materials provided by University of Nottingham. E. Pervolaraki, R. A. Anderson, A. P. Benson, B. Hayes-Gill, A. V. Holden, B. J. R. Moore, M. N. Paley, H. Zhang. Antenatal architecture and activity of the human heart.