Oregon State loses College World Series opener Mississippi State took the lead on Wes Rea's two-run double in the eighth inning, closer Jonathan Holder turned back two Oregon State threats, and the Bulldogs beat the Beavers, 5-4, on Saturday in the opening game of the College World Series at Omaha. The Bulldogs (49-18) advanced to a Monday game against Indiana or Louisville, who were playing the late game. The Beavers (50-12), seeded No. 3 in the nation, are one loss from elimination. Hunter Renfroe's hard comebacker off the leg of Matt Boyd (10-4) put runners on first and second in the eighth. Rea then sent a double into the right-center gap. Andy Detz scored easily and Renfroe beat second baseman Andy Peterson's relay throw home. Holder got out of a jam after Oregon State put two runners on base in the eighth, getting a fly-ball out and striking out pinch-hitter Joey Jansen. The Beavers had two runners on base again in the ninth when Danny Hayes drove a ball to right that Renfroe caught on the warning track to end the game and give Holder his 19th save. Ross Mitchell (13-0) pitched 2 2/3 shutout innings before turning the game over to Holder. Oregon State starter Andrew Moore turned in a strong performance after giving up three runs in the second inning. Moore, the Pac-12 freshman of the year, came into the game off wins in seven straight games and had worked eight or more innings in five of his previous six starts. Indiana 2, Louisville 0: Joey DeNato threw a four-hitter and the Hoosiers looked right at home in their first CWS appearance. Indiana is the first Big Ten team in Omaha since Michigan in 1984 and gave the conference its first win since the Wolverines beat Stanford in 1983. The Hoosiers manufactured their runs early, and DeNato (10-2) made them stand up in a masterful performance. DeNato yielded three singles and a double in his second complete game. Cody Green (10-4) took the loss. Indiana (49-18) has beaten the Cardinals (51-13) in three of four meetings, shutting them out twice.