Bills" Top Pick Plays Like One Quarterback E. J. Manuel, the 16th overall pick in this year's N.F.L. draft, went 16 of 21 for 107 yards and a touchdown Sunday to lead the Buffalo Bills to a 44-20 victory at Indianpolis in their preseason opener. Manuel was solid with his short passes and showed he could occasionally run, gaining 28 yards on three carries. He went 9 for 10 for 68 yards in the final two minutes of the first half, capping the drive with a 17-yard touchdown pass to Dorin Dickerson with 14 seconds left. "To do that is very impressive, no matter who you are," Bills Coach Doug Marrone said of Manuel's work on the drive. Another rookie, Marquise Goodwin, scored on a 107-yard kickoff return for the Bills. TITANS DROP SAFETY Tennessee waived safety Robert Johnson after he failed a physical. The Titans added two veterans to add depth at linebacker and safety. Johnson was a fifth-round draft pick in 2010. The Titans also waived defensive end Thaddeus Gibson to make room for linebacker Gary Guyton and safety Cory Lynch. 49ERS IMPROVISE With three of its top wideouts out with injuries, San Francisco started the unproven Marlon Moore opposite Anquan Boldin at receiver Friday night in its 10-6 exhibition loss to Denver. In limited playing time, the newcomer Austin Collie appeared healthy and effective while emerging as a veteran who could climb up an uncertain depth chart. RAVENS SIGN STOKLEY Baltimore signed wide receiver Brandon Stokley to a one-year contract. Stokley, 37, was drafted by the Ravens in the fourth round of the 1999 NF.L. draft.