Biologicals in Oncology Drug Pipeline Update 2012 NEW YORK, Feb. 29, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue: This drug pipeline update covers a wide array of biological drugs, such as: antibodies, proteins, peptides, DNA, RNA and cellular therapies. There are today 669 companies plus partners developing 1071 biological drugs in 2294 developmental projects in cancer. In addition, there are 17 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 676 drugs. Biologicals In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 408 different targets. These targets are further categorized on in the software application by 63 classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. How May Drug Pipeline Update Be of Use? Show investors/board/management that you are right on top of drug development progress in your therapeutic area. Find competitors, collaborations partners, M&A candidates etc. Jump start competitive drug intelligence operations Excellent starting point for world wide benchmarking Compare portfolio and therapy focus with your peers Speed up pro-active in-/out licensing strategy work Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes more than 669 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. Developmental stage This Drug Pipeline Update contains 1071 biological drugs in development, which have a total of 2294 developmental projects in cancer. In addition there are suspended and ceased drugs. Pipeline Breakdown According to Number of Drugs Marketed# 114 Registered# 1 Pre-registration# 7 Phase III# 69 Phase II# 241 Phase I# 258 Preclinical# 689 No Data# 7 Suspended# 17 Ceased# 676 Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included biological drugs are also in development for 273 other indications, where of 94 are different cancer indications. Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 408 different targets, divided into 63 classifications of molecular function: Acid phosphatase activity Antigen binding Auxiliary transport protein activity B cell receptor activity Carboxypeptidase activity Catalytic activity Cell adhesion molecule activity Chaperone activity Chemokine activity Cofactor binding Complement activity Cysteine-type peptidase activity Cytokine activity Defense/immunity protein activity DNA binding DNA repair protein DNA topoisomerase activity DNA-directed DNA polymerase activity Extracellular ligand-gated ion channel activity Extracellular matrix structural constituent G-protein coupled receptor activity Growth factor activity Growth factor binding GTPase activator activity GTPase activity Heat shock protein activity Hormone activity Hydrolase activity Isomerase activity Kinase binding Kinase regulator activity Ligand-dependent nuclear receptor activity Ligase activity Lipid phosphatase activity Metallopeptidase activity MHC class I receptor activity Molecular function unknown Oxidoreductase activity Peptidase activity Peptide hormone Protease inhibitor activity Protein binding Protein serine/threonine kinase activity Protein-tyrosine kinase activity Receptor activity Receptor binding Receptor signaling complex scaffold activity Receptor signaling protein serine/threonine kinase activity Receptor signaling protein tyrosine phosphatase activity RNA-directed DNA polymerase activity Serine-type peptidase activity Structural constituent of cytoskeleton Structural molecule activity Superoxide dismutase activity T cell receptor activity Transcription factor activity Transcription regulator activity Translation regulator activity Transmembrane receptor activity Transmembrane receptor protein tyrosine kinase activity Transporter activity Unclassified Unknown Identified targets are categorized into 29 different primary and alternate sub-cellular localizations: Apical membrane Cell surface Centrosome Clathrin-coated vesicle Cytoplasm Cytoplasmic vesicle Cytoskeleton Cytosol Endoplasmic reticulum Endosome Extracellular Extracellular matrix Golgi apparatus Immunological synapse Integral to membrane Lysosome Membrane fraction Mitochondrial matrix Mitochondrion Nucleolus Nucleus Perinuclear region Perinuclear vesicle Peroxisomal matrix Plasma membrane Sarcoplasmic reticulum Secreted Secretory granule Soluble fraction Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application. Target Expression Profile Direct links are provided from inside the application to 471 protein expression profiles of 303 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Pathway Referals Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath. BioCarta# 229 Pathways KEGG# 121 Pathways NetPath# 24 Signaling Pathways Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application. Mechanism In total there are different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target (s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target (s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile (s) of target (s) in various human tissues, cell lines and primary cells, including up to: Targeted Pathways Described target (s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs Drug status Clinical Trial Status Principle Investigator Partners Indication Developmental Stage Compound Type Target Molecular Function of Target Free text search of entire drug profile contents Direct linkage from inside the application to related internet resources Drug data is linked to search engines like Google and PubMed Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath Direct links to company web pages of principal investigators Dynamic Report Generator Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of. System Requirements Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion) Browser Application (Internet Explorer) Internet access (to access related internet resources) To order this report: Drug and Medication Industry: Biologicals in Oncology Drug Pipeline Update 2012 CONTACT: Nicolas Bombourg Reportlinker Email: nbo@reportlinker.com US: (805) 652-2626 Intl: +1 805-652-2626