Munch, Picasso, Cézanne and Rothko Go on the Block ODDS are 3-to-1 that when Edvard Munch's "Scream" comes up for sale at Sotheby's on Wednesday night, it will fetch $150 million to $200 million. And there's a 3-to-2 chance that pastel will become the most expensive artwork ever sold at auction, breaking the current record of $106.5 million set two years ago at Christie's for Picasso's "Nude, Green Leaves and Bust." As for who will buy "The Scream," bets are 5-to-2 that it will be a Russian, 3-to-1 an Asian or European and 4-to-1 an American. That's the thinking, anyway, from Ladbrokes, the British bookmaking chain, which has been analyzing the fate of what Sotheby's is billing as the most recognizable image in art history after the "Mona Lisa." The Andy Warhol Foundation for the Visual Arts Inc./Artists Rights Society (ARS), New York, via Sotheby's Artist Andy Warhol Title 'Double Elvis' Auction House Sotheby's Estimate $30 million to $50 million More Photos  The Munch Museum/Munch-Ellingsen Group, Artists Rights Society (ARS), New York, via Sotheby's Artist Edvard Munch Title 'The Scream' Auction House Sotheby's Estimate $80 million More Photos  Kate Rothko Prizel & Christopher Rothko/Artists Rights Society (ARS), New York, via Christie's Artist Mark Rothko Title 'Orange, Red, Yellow' Auction House Christie's Estimate $35 million to $45 million More Photos  Art isn't generally Ladbrokes's métier, but laying odds on just how much this work will get has even captured the attention of gamblers used to putting their money on horse races or boxing. Jessica Bridge, a spokeswoman for the company, said that the bookmakers "apply the same math and algorithms we do for football or hockey." While it is certain to be the big draw, "The Scream" is not the only highly recognizable work up for sale at Sotheby's, Christie's and Phillips de Pury over the next two weeks. Other highlights include a classic red abstract Rothko canvas; a Warhol image of Elvis Presley; a Picasso portrait of Dora Maar, the artist who was his lover and muse; and a watercolor of one of Cézanne's famed Card Players. What's bringing these paintings, drawings and sculptures to auction now? One reason is sheer serendipity, as several estates from seasoned collectors have come up for grabs this spring. The second is more opportunistic. Owners are hoping to cash in on the penchant of new, extraordinarily wealthy collectors from Russia, Asia and the Middle East for paying record prices for whatever strikes their fancy. "There are two markets, the regular market for the average collector and the super-market for global icons" that is fueled by the new rich, said Tobias Meyer, who runs Sotheby's contemporary art department worldwide. This last group is smart and gravitates toward the very top. Brett Gorvy, Mr. Meyer's counterpart at Christie's, says these buyers" "tastes are conservative but they want quality, technical virtuosity, beauty and color." Estimates are high for some of the best works this season, although Sotheby's figure of $80 million for "The Scream" is conservative by Ladbrokes's standards. After that are several paintings estimated to fall in the $30 million to $50 million range: a Roy Lichtenstein comic book image and a 1976 painting by Francis Bacon, as well as the red Rothko and the Warhol "Elvis." Back on the block are also several works, including "Circles and Angles," a stainless-steel sculpture by David Smith that failed to sell at Christie's when the market collapsed during the financial crisis of 2008. Now they have considerably lower estimates. If there are any striking differences between the offerings this month, it is the selection of postwar and contemporary art at Sotheby's and Christie's. Christie's won a group of works collected by David Pincus, a clothing manufacturer from Philadelphia who died in December, and his wife, Geraldine. Their collection includes a large number of Abstract Expressionist paintings. Sotheby's sale, on the other hand, features more classic Pop art. Some art historians, who declined to be named for fear of offending Sotheby's, laughed at the astronomical price predictions for "The Scream," even the seemingly lowball house estimate, calling the work too ugly to live with, depressing or mere kitsch. Whoever buys it will have a hefty insurance bill, not to mention round-the-clock security, to worry about. But were any new museum to add "The Scream" to its collection, that institution would become an immediate destination. The image of "The Scream" is so embedded in popular culture that it adorns products like mugs, mouse pads and inflatable dolls, even navel rings. Munch produced four versions of the composition. Three are in Norwegian museums and this one - a pastel on board from 1895 - is the only "Scream" left in private hands. It is being sold by Petter Olsen, a Norwegian businessman whose father, Thomas, was a friend and patron of the artist. The painting's fame is almost as much a liability for Sotheby's as it is an asset. Versions of it have been stolen twice, first in 1994, when two thieves entered the National Gallery of Norway in Oslo and fled with an 1893 "Scream," and then in 2004, when gunmen stole the 1910 version from the Munch Museum, also in Oslo. In both cases the paintings were recovered. This month Londoners had to go through metal detectors before entering the Sotheby's gallery where it was on view. The crowds were so great that auction house officials have decided not to open the presale viewing in New York to the public, as they usually do. Instead, only Sotheby's clients will have a chance to see the painting. Among those who saw "The Scream" in London the betting game has already begun. As for the rest of the art for sale, just where today's big money goes will be as much of a gamble as the fate of "The Scream." It is the unknown, after all, that has always been the allure of auctions. "The mystery is in the moment," Mr. Meyer said. Either people are in the mood to bid, or they're not.