Wall Street lower ahead of new data Stocks were lower Tuesday ahead of data on the manufacturing sector that could offer evidence on the pace of the economic recovery. The S&P 500 closed April with its first monthly decline since November as economic data pointed to a slowing domestic economy and continued flare-ups in the euro zone highlighted the risks of the region's debt crisis. Investor focus will be dominated by the United States as a number of European and Asian stock markets, including ones in Germany, France and Italy, are closed on Tuesday for the May Day holiday. The Institute for Supply Management will releases its April manufacturing index at 10 a.m. Economists in a Reuters survey expected a reading of 53.0 versus 53.4 in March. "We have holidays - Japan, China, and Europe's May Day holiday as well - so I'm not that surprised by the quiet," said Frank Lesh, a futures analyst and broker at FuturePath Trading LLC in Chicago. I wonder if we will have a big reaction (to ISM) because of a lack of players at the moment, so it might be a short-lived reaction. It seems like the market is expecting a little bit of weakness and we should be able to take that in stride if that's what it is - a little bit. Pfizer Inc reported better-than-expected quarterly earnings as cost controls offset plunging Lipitor sales as the cholesterol fighter faced generic competition. According to Thomson Reuters data through Monday morning, of the 297 S&P 500 companies that have reported results, 72 percent topped estimates. Shares of PF Chang's China Bistro Inc surged after the restaurant chain agreed to be bought by a private equity firm. U.S. auto sales in April are expected to remain on pace with the previous month as appetite for new vehicles drove first-quarter demand to its highest rate in four years. Reuters contributed to this report.