Itineraries - America's greatest Main Streets Woods Pierce Staunton, Va. is blessed with the backdrop of the Shenandoah Valley and the main artery of Beverley Street, whose brick buildings amount to one of the highest concentrations of showy late-19th-century architecture in any U.S. town. By Wayne Curtis , Travel + Leisure Driving across America, it's all too easy to lose your mooring amid the commercial thicket of the same old fast-food outlets and big-box stores. Slideshow: See the greatest Main Streets in the U.S.A. But push on a mile or two beyond the interstate exit, and you may discover a town that's anchored by a distinctive Main Street - one with grand architecture, eclectic small businesses and community-oriented features such as a park or theater. Often it thrives thanks to locals who have made a conscientious effort to fight the general decline of Main Street. The work of such activists and preservationists is acknowledged each year by the National Trust for Historic Preservation's Great American Main Streets Awards and by the American Planning Association's Great Places in America: Streets. We scoured their recent designations to select the most vibrant, distinctive downtowns worth the trip. You'll find these great Main Streets across the U.S., from mining towns such as Silver City, N.M., to stately, red-brick Staunton, Va. Yet our list does skew east of the Mississippi, favoring towns that were established before the age of the automobile - and so display the DNA of a pedestrian and bike-friendly environment. Not that a walkable layout can guarantee a thriving Main Street. Take York, Penn., where the 1978 shuttering of the last of four downtown department stores triggered a period of decay. The turnaround was slow going, as landowners aided by various programs renovated nearly every Victorian and Classical Revival façade. Now, on the first Friday of each month, local businesses stay open late, with special events and discounts. Port Townsend, Wash., went through its own reinvention. Expecting a shipping boom, 19th-century residents built out the town in high Victorian style - only to find themselves on the wrong side of Puget Sound when the railroads connected to Seattle. It's been reborn as an arts center around the main drag, Water Street. Second chances are just as American as a homespun Main Street, and with the recent economic downturn have come do-it-yourselfers seeing opportunity in cheap abandoned storefronts and converting them into bakeries or boutiques. So it's well worth driving a extra few miles to see what Main Street lies ahead.