Matchup: Giants (3-2) at 49ers (4-1) 4:25 p.m. Eastern, Fox MATCHUP to watch 49ers' Aldon Smith vs. Giants' offensive line Eli Manning was knocked down often in the last meeting between these teams, and containing Smith will be the key if the Giants hope to avoid a similarly difficult day for Manning. Smith is a consistent threat on the edge and leads the 49ers with four and a half sacks this season. NUMBER to watch That's how many 100-yard rushers the 49ers' defense has allowed over the past 43 games, making it a particularly daunting task for Giants running back Ahmad Bradshaw. Bradshaw, who carried 30 times last Sunday against Cleveland, has been especially confident this week after totaling a career-high of 200 yards against the Browns. 'I just tell my ring to try to hold tight, and I hope another one comes near you, that's all. I try to wipe the dust off of it - I've got it hidden right now.' 49ers receiver Mario Manningham, revealing that he speaks to his Giants Super Bowl ring.