Will Greenwood: is it time for an English club to win the Heineken Cup? Leicester and Harlequins will think so Pool 3: Harlequins (Biarritz, Connacht, Zebre) Quins hit the jackpot of European groups. They have two of the bottom three sides in the Rabo Pro, while Biarritz got slaughtered at home last week. If you are a French side losing in your own stadium then you are in trouble - they could easily fail on the road in either Ireland or Italy. For Quins, I would have to go back a long way in the history books to find an easier group. This is an English side's most glaring opportunity, even after the Quins' recent back-to-back losses domestically, to head out of pool stages as No 1 seeds. I know, I know Connacht beat them last year, but that was in ridiculous conditions. Zebre, the Italian side, are a walking 10 points. Quins have to emerge as pool winners. And then face Leicester in the quarters. Don't miss: Biarritz v Quins (round six) - Quins will view this as the toughest of their six fixtures, Quins can, and should, be one of the the top two seeds in the competition coming out of this group. You might as well win in France, as you must do to win the Cup, in the pool stages. If they do, Quins can romp through the group unbeaten and set off trying to become the first team to win nine from nine. Pool 4: Northampton (Castres, Ulster, Glasgow) This pool is very similar to pool one. A group of teams that could, on any night, beat each other. I might be being a bit kind to Glasgow, but they have a big game in them, even if backing it up in Europe could prove a bit of a problem. Northampton looked on fine form until they hit a road bump last week against Irish. It told us that if you can match Saints up front then you can limit the damage their backs can do. Saints need George Pisi back sharpish and have to try to get Ben Foden back for their December games. Without them Saints don't have enough poachers, and that's why I have Ulster to win this group. Saints will battle valiantly, but I worry they don't have enough muscle to bully in Europe. Ulster to head to Toulouse in quarter. Don't miss: Northampton v Ulster (round four) - Some group games in this current climate are as good as knock-out specials from yesteryear. This game has the feel of a good-old heavyweight quarter or semi-final. In a group where everyone can beat each other, home games are essential to ensure survival. The hits of Lawes and Ferris will be as powerful as any hits from the last 16 years. Pool 5: Exeter (Scarlets, Clermont, Leinster) If Quins have picked the easiest group in living history, the Exeter Chiefs have managed the opposite with what could be the toughest ever for an English side. Leinster certainly has the greatest squad ever. And Clermont came within a Wesley Fofana fingernail last year of beating them. And the Scarlets have 38 tries in the top 40 greatest Heineken Cup scores. Holy mother of rugby, forsake me now for they know not what they have done - Exeter are in trouble. Let's be honest, there is no pressure on them and they can learn in a few months just what it takes to be the best in Europe. Exeter will love these guys rolling into town, will pull up their sleeves and have a crack. The Chiefs have a tremendous away record in the Aviva Premiership and the players and fans will relish the away trips. Can I see them getting out of this group? Not really. Leinster will play Munster in the last eight at home, with my old friends Clermont against Toulon in the other quarter-final. Don't miss: Leinster v Clermont (round four) - A re-run of a quarter-final from a few years back when Brock James, who I rate as highly as any footballing fly-half out there, had his nightmare drop-goal moment. He got the yips and Clermont had to face another early exit from a tournament I am convinced they are, one day, destined to win. Watch out for the new kid at the back for Clermont, Buttin. Pool 6: Sale (Toulon, Cardiff, Montpellier) What the heck has happened up at Sale? In the summer there were some marquee signings, a new stadium, a nice brand of Northern optimism. Then the season started and they can't buy a win. Tricky one this. Their squad is not ridiculously fat in talent, bottom of the Aviva, and they will be focusing on the next two rounds of the Premiership where they have Worcester and Irish, two teams they are keen to drag down. An oddly French way to look at things, I know, but while it is great to be in the top echelons of European competition, it is more important to stay in the top flight domestically. Focus may stay on the domestic front and chances of progression limited by mindset. Toulon will scare the living day lights out of everyone in this group, and will be the only team to progress, facing Clermont at home in quarters. Don't miss: Sale v Toulon (round three) - You would imagine that this should be the case of England's two most handsome fly-halves clashing. But with Cipriani struggling for his form, and playing second fiddle, and Wilkinson missing the odd away game to allow none other than Freddie Michalak to get a game, we have to cross our fingers to see a head-to-head. Although perhaps the return of Andrew Sheridan might be the most important selection of them all. Toulon, like Quins, may need this victory to secure one of the two top seed slots. Not sure all of Toulon's world XV players will be pushing past each other to leave the south coast of France for a trip to Salford. My predicted last eight: