Two people died in a house fire in northern Brisbane, as three others are being treated in hospital. A MAN and woman killed in a house fire in north Brisbane probably died of smoke inhalation, police say. The bodies of the man, believed to be in his 40s, and the woman were found in bed in the main bedroom of the two-storey family home in Bracken Ridge. "Indications are that they didn't wake up," Detective Inspector Graham Clark told reporters. He said there did not appear to be suspicious circumstances and it was too early to say where the fire started. Firefighters said a girl, 17, a man, 20, and a woman, 21, had escaped the blaze. The teen is in a critical condition in the hospital with burns to her chest and face. The 20-year-old man has minor burns to his legs and injuries to his feet and hands from jumping from the house. Queensland Fire and Rescue Service Inspector Paul Durston said the fire conditions were extreme. It was heavily smoke-logged. They did a tremendous effort to actually make entry," he told reporters. Neighbours woke to screams and the sounds of smoke alarms. Some ripped a fence down to help the occupants escape the yard. They grabbed a hose and tried in vain to douse the inferno. I've never seen anything that intense. It was crazy," neighbour Matt Bailey told reporters. He said he heard glass smashing and saw the fire spreading up the stairs of the house. Dylan Grove saw a woman in hysterics run from the house, bleeding from the foot. "She was saying, 'my family's still in there'," he told AAP. We tried, but there was no way we were getting in there.