Fatalities, injuries reported in Tennessee highway wreck From Drew Iden, CNN October 2, 2013 -- Updated 1952 GMT (0352 HKT) A bus traveling east on I-40 Wednesday crossed the median, striking a tractor-trailer and a car. Tour bus was headed east on I-40 east of Knoxville It apparently crossed median and struck a semi and a car Officials said multiple fatalities, injuries were reported (CNN) -- A wreck Wednesday involving a tractor-trailer, a tour bus and a passenger vehicle resulted in multiple fatalities and injuries, the Tennessee Highway Patrol said. The 2 p.m. wreck occurred about 40 miles east of Knoxville on Interstate 40 westbound near mile marker 423, said Tennessee Department of Safety spokeswoman Dalya Qualls. The bus was traveling east on I-40 and for an unknown reason crossed the median, striking the westbound tractor-trailer and the passenger car, Qualls said. The tractor-trailer caught fire, and the bus overturned, she said. A photo from CNN affiliate WVLT showed smoke rising from the scene and debris along the highway. There was no immediate report describing the nature and number of injuries. I-40 was closed, and traffic was being rerouted, according to state transportation officials. The scene was expected to be cleared by 9 p.m.