Three California Students Win Regional Siemens Competition at California Institute of Technology... -- PASADENA, Calif., Nov. 17, 2013 /PRNewswire/ -- PASADENA, Calif., Nov. 17, 2013 /PRNewswire/ -- Months of dedication and hard work in science, technology, engineering and mathematics (STEM) paid off tonight for three students named National Finalists in the Siemens Competition in Math, Science & Technology, the nation's premier research competition for high school students. Eric Chen of San Diego, Calif. earned the top individual honors and a $3,000 scholarship for discovering potent influenza endonuclease inhibitors, which could be used to develop anti-flu drugs. Andrew Jin of San Jose, Calif. and Steven Wang of Los Altos, Calif. earned top team honors and a $6,000 scholarship for their research on synergistic chemotherapy drug combinations, which could enhance cancer treatment. The students presented their research this weekend to a panel of judges from the California Institute of Technology (Caltech), host of the Region One Finals. The Winning Individual Eric Chen, a senior at Canyon Crest Academy in San Diego, Calif., won the individual category and a $3,000 college scholarship for his project titled, Discovery of Novel Influenza Endonuclease Inhibitors to Fight Flu Pandemic. For his project, Eric combined computer modeling with experimental research to discover influenza virus inhibitors. These findings could be used to develop new anti-flu drugs that will help protect people against future pandemic outbreaks. "Eric developed a comprehensive and novel approach to develop a general drug for influenza," said Jim Heath, competition judge and professor of chemistry at Caltech. He not only conceived the project, but he also independently carried out many different aspects of the work using computational chemistry, structural biology and combinatorial chemistry. Eric is getting closer to developing an important antiviral treatment by advancing a new, integrated approach to drug discovery. Eric was inspired to pursue research on influenza after the swine flu outbreak started in his hometown of San Diego in 2009. Eric earned the Google Science Fair Grand Prize and the Intel International Science and Engineering Fair Grand Prize Award. He is the founder and head coach of a summer math contest program for middle school students and helped start Science Fair and Science Olympiad programs at his town's primary and middle schools. He plans to become a college professor or an entrepreneur. Eric's project mentors were Dr. Rommie Amaro, assistant professor, and Dr. Gen-Sheng Feng, professor, both of the University of California, San Diego. The Winning Team Andrew Jin and Steven Wang, juniors at The Harker School in San Jose, Calif., won the team category and a shared scholarship of $6,000 for their project entitled, Rational Discovery and Optimization of Synergistic Chemotherapy Combinations: A Novel Framework Integrating Gene Perturbation Analysis and Machine Learning Algorithms. Andrew and Steven used virtual computer modeling and biological experimentation to speed up the discovery of effective anti-cancer drug combinations. The team demonstrated that these drug combinations can enhance potency, reduce toxicity and prevent resistance of chemotherapy treatments. Moreover, the students' discovery could shorten the time it takes pharmaceutical manufacturers to create first-in-class anti-cancer drugs. "Andrew and Steven cleverly leveraged existing data on gene expression and cancer treatments to discover new synergetic combinations of drugs that work better together than alone," said Jeffrey Mendez, competition judge and chemistry instructor at Caltech. In addition to their sophisticated computational approaches, they obtained rigorous experimental validation. Much like their drug combinations, these two students achieved a combined result that was stronger than the sum of its parts. Andrew is an officer in his school's science research club and volunteers for the Breakthrough Silicon Valley program, through which he tutors underprivileged high school students in math and science. He is captain of his school's public forum debate team, serves as an active member of the Boy Scouts and plays classical piano. He plans to start a company in either the high-tech or health industry, or become a research professor. Steven was inspired to pursue his research project after his father passed away from colon cancer. In his memory, he hopes to find a cure. Steven earned National Semifinalist distinctions at the Tournament of Champions in Extemporaneous Speaking and was part of the first-place winning team at Technology Students Association Tests of Engineering Aptitude, Math and Science. He participates in speech and debate, volunteers for the American Cancer Society and plays baseball. He plans to pursue a career in medicine or computer programming. The team's project mentors were Dr. Andrew Beck, assistant professor of pathology and director of the Molecular Epidemiology Research Laboratory at Beth Israel Deaconess Medical Center and Harvard Medical School; Dr. Dobrin Dragonov, post-doctoral research fellow in the department of Cancer Immunotherapeutics & Tumor Immunology at City of Hope National Medical Center; and Dr. Peter Lee, the Billy and Audrey L. Wilder Professor and chair of the Department of Cancer Immunotherapeutics & Tumor Immunology at City of Hope National Medical Center. Charles Li, California High School, San Ramon, Calif. Sidhanth Venkatasubramaniam, Palo Alto High School, Palo Alto, Calif. Emily Wang, Henry M. Gunn High School, Palo Alto, Calif. George Wu, La Jolla High School, La Jolla, Calif. Ayesha Bajwa, Castilleja School, Palo Alto, Calif.; and Smriti Pramanick, Castilleja School, Palo Alto, Calif. Anin Sayana, Bellarmine College Preparatory, San Jose, Calif.; and Milan Gambhir, Bellarmine College Preparatory, San Jose, Calif. Anna Zeng, Mission San Jose High School, Fremont, Calif.; and Kevin Zeng, Mission San Jose High School, Fremont, Calif. Kristine Zhang, Saratoga High School, Saratoga, Calif.; and David Ma, Mission San Jose High School, Fremont, Calif.