Texas A&M quarterback Johnny Manziel (2) celebrates after throwing a touchdown pass to Malcome Kennedy during the third quarter of an NCAA college football game against Mississippi State Saturday, Nov. 9, 2013, in College Station, Texas. Texas A&M quarterback Johnny Manziel (2) throws a pass against Mississippi State during the first quarter of an NCAA college football game Saturday, Nov. 9, 2013, in College Station, Texas. COLLEGE STATION, Texas (AP) - Johnny Manziel threw for 446 yards and tied a career-high with five touchdown passes to lead No. 11 Texas A&M to a 51-41 win Saturday over Mississippi State in what could be the Heisman Trophy winner's last home game. The crowd chanted "one more year" late in the game for Manziel, who is eligible for the draft after this season. Whether he comes back remains to be seen, but he went into the stands to celebrate with the student section when the game was over. Among the crowd of 88,504, third largest ever at A&M, on hand to see Manziel play at Kyle Field for the possibly final time was former President George H.W. Bush and former Texas A&M and current St. Louis Cardinals pitcher Michael Wacha. Texas governor Rick Perry was the co-pilot in the pre-game flyover and also attended the game Mississippi State cut the lead to 10 points early in the fourth quarter, but Manziel threw his fifth touchdown pass to make it 44-27 for A&M (8-2, 4-2 Southeastern Conference). The defense grabbed an interception and Ben Malena's 2-yard TD run extended the lead to 51-27. Dax Prescott threw for 149 yards and two scores and ran for 154 yards for Mississippi State (4-5, 1-4). Malcome Kennedy and Travis Labhart had two touchdown receptions each. Mike Evans had 116 yards receiving to break the school single-season record with 1,263. Manziel set a school career record for total yards with 9,040 and a single-season record with 31 touchdown passes. He became just the second A&M quarterback to run for 2,000 yards in a career and has 3,313 yards passing this year to become the first Aggie with two 3,000-yard passing seasons. The Bulldogs got within 10 points again after a touchdown throw by Tyler Russell with 2:19 remaining. But the onside kick was recovered by A&M. Bulldogs receiver Jameon Lewis threw a touchdown pass to Joe Morrow on a reverse early in the fourth quarter to get within 37-27. Trey Williams returned the ensuing kickoff 100 yards for a touchdown. But it was negated by an unsportsmanlike conduct penalty after he flipped into the end zone. The Aggies got the ball at the 18 and Manziel threw his fifth touchdown pass three plays later. The Bulldogs cut the lead to 10 points late in the third quarter on a touchdown pass by Prescott. But A&M made it 37-20 two plays later on a 15-yard run by Williams. That scored was set up by a 75-yard reception by Evans. Russell started the game in place of Prescott, who missed practice this week after his mother died of cancer on Sunday. Prescott entered the game on Mississippi State's third drive and got the majority of the snaps after that. Prescott's twitter profile had three pictures of him and his mother, the biggest one featuring him kissing her bald head as she smiled broadly. Before the game he tweeted: "I Live for you, I Play for you #MOM." Manziel was intercepted three times, twice by Jamerson Love. The turnovers helped keep Mississippi State in the game, but the Bulldogs couldn't keep up with the Aggies. Manziel evaded the rush and connected with Kennedy for a 21-yard touchdown to extend Texas A&M's lead to 30-14 in the third quarter. Manziel had a highlight-reel play on A&M's next drive when he did a nifty spin move to avoid a defender before dashing away and Derel Walker for a 26-yard gain on third-and-25. But Manziel's third interception came two plays later when Nickoe Whitley picked him off inside the 5 yard line. Manziel threw a 12-yard touchdown pass to Kennedy to give A&M a 7-0 lead midway through the first quarter. Prescott entered the game for the first time on Mississippi State's next drive and Josh Robinson ran 51 yards for a touchdown on the first play to tie it at 7-7. Texas A&M's 12th man Sam Moeller blocked the punt and it rolled out of the end zone for a safety to put A&M up 9-7. Manziel's threw a 33-yard touchdown to Labhart extend A&M's lead to 16-7 late in the first quarter. Prescott's 3-yard jump pass to 6-foot-5 De'Runnya Wilson for a touchdown got Mississippi State within 16-14 about a minute before halftime. Manziel hit Labhart for an 11-yard score on the next play to leave A&M up 23-14 at the break.