<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/upheno/patterns/imports/nbo_import.owl#"
     xml:base="http://purl.obolibrary.org/obo/upheno/patterns/imports/nbo_import.owl"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:obo="http://purl.obolibrary.org/obo/"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:xml="http://www.w3.org/XML/1998/namespace"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:swrl="http://www.w3.org/2003/11/swrl#"
     xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#"
     xmlns:swrlb="http://www.w3.org/2003/11/swrlb#"
     xmlns:terms="http://purl.org/dc/terms/"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
    <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/upheno/patterns/imports/nbo_import.owl"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/IAO_0000111 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000111"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000112 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000112"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000114 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000114"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <rdfs:label>definition</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000116 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000116"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000117 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000118 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000119 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000232 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000232"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000424 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000424"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000589 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000589"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000600 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000600"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_isReversiblePropertyChain -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_isReversiblePropertyChain"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001900 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001900"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002575 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002575"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002581 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002581">
        <obo:IAO_0000115>If R &lt;- P o Q is a defining property chain axiom, then it also holds that R -&gt; P o Q. Note that this cannot be expressed directly in OWL</obo:IAO_0000115>
        <rdfs:label>is a defining property chain axiom</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002582 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002582">
        <obo:IAO_0000115>If R &lt;- P o Q is a defining property chain axiom, then (1) R -&gt; P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.</obo:IAO_0000115>
        <rdfs:label>is a defining property chain axiom where second argument is reflexive</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002604 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002604"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004049 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004049"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004050 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004050"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0040042 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0040042"/>
    


    <!-- http://purl.obolibrary.org/obo/UBPROP_0000001 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000001"/>
    


    <!-- http://purl.obolibrary.org/obo/UBPROP_0000003 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000003"/>
    


    <!-- http://purl.obolibrary.org/obo/UBPROP_0000008 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000008"/>
    


    <!-- http://purl.obolibrary.org/obo/UBPROP_0000012 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000012"/>
    


    <!-- http://purl.org/dc/elements/1.1/date -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/date"/>
    


    <!-- http://purl.org/dc/elements/1.1/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/source"/>
    


    <!-- http://purl.org/dc/terms/creator -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/creator"/>
    


    <!-- http://purl.org/dc/terms/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/source"/>
    


    <!-- http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled -->

    <owl:AnnotationProperty rdf:about="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#created_by -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#created_by"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#creation_date -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#creation_date"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#date_retrieved -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#date_retrieved"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#external_class -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#external_class"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#external_ontology -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#external_ontology"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasAlternativeId -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym">
        <rdfs:label>has_broad_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasExactSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym">
        <rdfs:label>has_exact_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym">
        <rdfs:label>has_narrow_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
        <rdfs:label>has_related_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasSynonymType -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasSynonymType"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#id -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#inSubset -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#is_cyclic -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#is_cyclic"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#is_transitive -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#is_transitive"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#ontology -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#ontology"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#shorthand -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#shorthand"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#source -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#source"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#xref -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#xref"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#comment -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#comment"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#label -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>
    


    <!-- http://xmlns.com/foaf/0.1/depicted_by -->

    <owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/depicted_by"/>
    


    <!-- http://xmlns.com/foaf/0.1/page -->

    <owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/page"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000111 xml:lang="en">is part of</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">my brain is part of my body (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this day is part of this year (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a core relation that holds between a part and its whole</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)

A continuant cannot be part of an occurrent: use &apos;participates in&apos;. An occurrent cannot be part of a continuant: use &apos;has participant&apos;. A material entity cannot be part of an immaterial entity: use &apos;has location&apos;. A specifically dependent continuant cannot be part of an independent continuant: use &apos;inheres in&apos;. An independent continuant cannot be part of a specifically dependent continuant: use &apos;bearer of&apos;.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">part_of</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <oboInOwl:hasDbXref>BFO:0000050</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>part_of</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:shorthand>part_of</oboInOwl:shorthand>
        <rdfs:label>part of</rdfs:label>
        <rdfs:label xml:lang="en">part of</rdfs:label>
        <rdfs:label>part_of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections"/>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:PartOf"/>
        <rdfs:seeAlso>http://www.obofoundry.org/ro/#OBO_REL:part_of</rdfs:seeAlso>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000051 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000051">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000111 xml:lang="en">has part</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">my body has part my brain (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this year has part this day (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000115>Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">a core relation that holds between a whole and its part</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)

A continuant cannot have an occurrent as part: use &apos;participates in&apos;. An occurrent cannot have a continuant as part: use &apos;has participant&apos;. An immaterial entity cannot have a material entity as part: use &apos;location of&apos;. An independent continuant cannot have a specifically dependent continuant as part: use &apos;bearer of&apos;. A specifically dependent continuant cannot have an independent continuant as part: use &apos;inheres in&apos;.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_part</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:hasDbXref>BFO:0000051</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>has_part</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:is_cyclic rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_cyclic>
        <oboInOwl:shorthand>has_part</oboInOwl:shorthand>
        <rdfs:comment>We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality &apos;swollen&apos; necessarily comes with the qualities of &apos;protruding&apos; and &apos;increased size&apos;.</rdfs:comment>
        <rdfs:label>has part</rdfs:label>
        <rdfs:label xml:lang="en">has part</rdfs:label>
        <rdfs:label>has_part</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000062 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000062">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002086"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000062"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">preceded by</obo:IAO_0000111>
        <obo:IAO_0000115>X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) &lt;= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is preceded by</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">preceded_by</obo:IAO_0000118>
        <dc:source>http://www.obofoundry.org/ro/#OBO_REL:preceded_by</dc:source>
        <oboInOwl:hasDbXref>BFO:0000062</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>is preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>takes place after</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>preceded_by</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:shorthand>preceded_by</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">preceded by</rdfs:label>
        <rdfs:label>preceded_by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>is preceded by</owl:annotatedTarget>
        <oboInOwl:hasDbXref>SIO:000249</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>takes place after</owl:annotatedTarget>
        <oboInOwl:hasDbXref>Allen:precedes</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000063 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000063">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000063"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">precedes</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) &lt;= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BFO:0000063</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>precedes</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:shorthand>precedes</oboInOwl:shorthand>
        <rdfs:label>precedes</rdfs:label>
        <rdfs:label xml:lang="en">precedes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000066 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000066">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000067"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">occurs in</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">b occurs_in c =def b is a process and c is a material entity or immaterial entity&amp; there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.&amp; forall(t) if b exists_at t then c exists_at t &amp; there exist spatial regions s and s’ where &amp; b spatially_projects_onto s at t&amp; c is occupies_spatial_region s’ at t&amp; s is a proper_continuant_part_of s’ at t</obo:IAO_0000115>
        <obo:IAO_0000118 xml:lang="en">occurs_in</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">unfolds in</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">unfolds_in</obo:IAO_0000118>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:comment>Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">occurs in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000067 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000067">
        <obo:IAO_0000111 xml:lang="en">site of</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">[copied from inverse property &apos;occurs in&apos;] b occurs_in c =def b is a process and c is a material entity or immaterial entity&amp; there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.&amp; forall(t) if b exists_at t then c exists_at t &amp; there exist spatial regions s and s’ where &amp; b spatially_projects_onto s at t&amp; c is occupies_spatial_region s’ at t&amp; s is a proper_continuant_part_of s’ at t</obo:IAO_0000115>
        <rdfs:comment>Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">contains process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000052 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000052">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002314"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <obo:IAO_0000111 xml:lang="en">inheres in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this fragility inheres in this vase</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this red color inheres in this apple</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A dependent inheres in its bearer at all times for which the dependent exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">inheres_in</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">inheres in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000053 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000053">
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000111 xml:lang="en">bearer of</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this apple is bearer of this red color</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this vase is bearer of this fragility</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">bearer_of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">is bearer of</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:hasDbXref>RO:0000053</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>bearer_of</oboInOwl:id>
        <oboInOwl:shorthand>bearer_of</oboInOwl:shorthand>
        <rdfs:label>bearer of</rdfs:label>
        <rdfs:label xml:lang="en">bearer of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000056 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000056">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000111 xml:lang="en">participates in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this blood clot participates in this blood coagulation</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this input material (or this output material) participates in this process</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigator participates in this investigation</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a continuant and a process, in which the continuant is somehow involved in the process</obo:IAO_0000115>
        <obo:IAO_0000118 xml:lang="en">participates_in</obo:IAO_0000118>
        <rdfs:label xml:lang="en">participates in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000057 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000057">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0000057"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">has participant</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this blood coagulation has participant this blood clot</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigation has participant this investigator</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this process has participant this input material (or this output material)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a process and a continuant, in which the continuant is somehow involved in the process</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_participant</obo:IAO_0000118>
        <dc:source>http://www.obofoundry.org/ro/#OBO_REL:has_participant</dc:source>
        <rdfs:label xml:lang="en">has participant</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000081 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000081">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
        <obo:IAO_0000112 xml:lang="en">this investigator role is a role of this person</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is role of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">role_of</obo:IAO_0000118>
        <rdfs:label xml:lang="en">role of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <obo:IAO_0000112 xml:lang="en">this person has role this investigator role (more colloquially: this person has this role of investigator)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_role</obo:IAO_0000118>
        <oboInOwl:hasDbXref>RO:0000087</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>has_role</oboInOwl:id>
        <oboInOwl:is_cyclic rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_cyclic>
        <oboInOwl:is_transitive rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_transitive>
        <oboInOwl:shorthand>has_role</oboInOwl:shorthand>
        <rdfs:label>has role</rdfs:label>
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002013 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002013">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002017"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <obo:IAO_0000115>A &apos;has regulatory component activity&apos; B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:30:46Z</oboInOwl:creation_date>
        <rdfs:label>has regulatory component activity</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002014 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002014">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002013"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002335"/>
        <obo:IAO_0000115>A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A &apos;has regulatory component activity&apos; B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:31:01Z</oboInOwl:creation_date>
        <rdfs:comment>By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component &apos;glutamate binding&apos; and negative regulatory components including &apos;zinc binding&apos; and &apos;magnesium binding&apos;.</rdfs:comment>
        <rdfs:label>has negative regulatory component activity</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002015 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002015">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002013"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002336"/>
        <obo:IAO_0000115>A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A &apos;has regulatory component activity&apos; B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:31:17Z</oboInOwl:creation_date>
        <rdfs:comment>By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component &apos;ligand binding&apos;.</rdfs:comment>
        <rdfs:label>has positive regulatory component activity</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002017 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002017">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002018"/>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:44:33Z</oboInOwl:creation_date>
        <rdfs:comment>A &apos;has component activity&apos; B if A is A and B are molecular functions (GO_0003674) and A has_component B.</rdfs:comment>
        <rdfs:label>has component activity</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002018 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002018">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002180"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>w &apos;has process component&apos; p if p and w are processes,  w &apos;has part&apos; p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:49:21Z</oboInOwl:creation_date>
        <rdfs:label>has component process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002022 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002022">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:24Z</oboInOwl:creation_date>
        <rdfs:comment>Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</rdfs:comment>
        <rdfs:label>directly regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2000/01/rdf-schema#comment"/>
        <owl:annotatedTarget>Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002023 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002023">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
        <obo:IAO_0000115>Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:38Z</oboInOwl:creation_date>
        <rdfs:label>directly negatively regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002023"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002024 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002024">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
        <obo:IAO_0000115>Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:47Z</oboInOwl:creation_date>
        <rdfs:label>directly positively regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002024"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002025 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002025">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002017"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <obo:IAO_0000115>A &apos;has effector activity&apos; B if A and B are GO molecular functions (GO_0003674),  A &apos;has component activity&apos; B and B is the effector (output function) of B.  Each compound function has only one effector activity.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-22T14:14:36Z</oboInOwl:creation_date>
        <rdfs:comment>This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.</rdfs:comment>
        <rdfs:label>has effector activity</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A &apos;has effector activity&apos; B if A and B are GO molecular functions (GO_0003674),  A &apos;has component activity&apos; B and B is the effector (output function) of B.  Each compound function has only one effector activity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002086 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002086">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:comment xml:lang="en">X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)</rdfs:comment>
        <rdfs:label xml:lang="en">ends after</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002087 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002087">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002090"/>
        <obo:IAO_0000115>X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)</obo:IAO_0000115>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <obo:IAO_0000118>starts_at_end_of</obo:IAO_0000118>
        <obo:UBPROP_0000001>A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].</obo:UBPROP_0000001>
        <oboInOwl:hasDbXref>RO:0002087</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>directly preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>is directly preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>is immediately preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>starts_at_end_of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>immediately_preceded_by</oboInOwl:id>
        <oboInOwl:shorthand>immediately_preceded_by</oboInOwl:shorthand>
        <rdfs:comment xml:lang="en">X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)</rdfs:comment>
        <rdfs:label xml:lang="en">immediately preceded by</rdfs:label>
        <rdfs:label>immediately_preceded_by</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/SIO_000251"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/UBPROP_0000001"/>
        <owl:annotatedTarget>A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].</owl:annotatedTarget>
        <oboInOwl:source>SIO:000251</oboInOwl:source>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>is immediately preceded by</owl:annotatedTarget>
        <oboInOwl:hasDbXref>SIO:000251</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002090 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002090">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <obo:IAO_0000118>ends_at_start_of</obo:IAO_0000118>
        <obo:IAO_0000118>meets</obo:IAO_0000118>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:comment xml:lang="en">X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)</rdfs:comment>
        <rdfs:label xml:lang="en">immediately precedes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002131 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002131">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002323"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002131"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002131"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>x overlaps y if and only if there exists some z such that x has part z and z part of y</obo:IAO_0000115>
        <obo:IAO_0000424>http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)</obo:IAO_0000424>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">overlaps</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002176 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002176">
        <obo:IAO_0000115>Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.</obo:IAO_0000115>
        <obo:IAO_0000116>this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)</obo:IAO_0000116>
        <oboInOwl:hasDbXref>RO:0002176</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>connects</oboInOwl:id>
        <oboInOwl:shorthand>connects</oboInOwl:shorthand>
        <rdfs:label>connects</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002176"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002177 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002177">
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <oboInOwl:hasDbXref>RO:0002177</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>attaches_to_part_of</oboInOwl:id>
        <oboInOwl:shorthand>attaches_to_part_of</oboInOwl:shorthand>
        <rdfs:label>attaches_to_part_of</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002177"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:IAO_isReversiblePropertyChain>true</obo:IAO_isReversiblePropertyChain>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002180 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002180">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>w &apos;has component&apos; p if w &apos;has part&apos; p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.</obo:IAO_0000115>
        <obo:IAO_0000116>The definition of &apos;has component&apos; is still under discussion. The challenge is in providing a definition that does not imply transitivity.</obo:IAO_0000116>
        <obo:IAO_0000232 xml:lang="en">For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like &apos;has part exactly 5 digit, you would instead use has_component exactly 5 digit.</obo:IAO_0000232>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">has component</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:Componency"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002211 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002211">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002025"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002578"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002578"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000116>We use &apos;regulates&apos; here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of &apos;causally upstream of or within&apos; (aka influences). Consider relabeling to make things more explicit</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>David Hill</obo:IAO_0000117>
        <obo:IAO_0000117>Tanya Berardini</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000119>GO</obo:IAO_0000119>
        <obo:IAO_0000232>Regulation precludes parthood; the regulatory process may not be within the regulated process.</obo:IAO_0000232>
        <obo:IAO_0000589>regulates (processual)</obo:IAO_0000589>
        <obo:IAO_0000600 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</obo:IAO_0000600>
        <oboInOwl:hasDbXref>RO:0002211</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:id>regulates</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:shorthand>regulates</oboInOwl:shorthand>
        <rdfs:label>regulates</rdfs:label>
        <rdfs:label xml:lang="en">regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002212 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002212">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002305"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002335"/>
        <obo:IAO_0000115>Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>negatively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">negatively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002213 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002213">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002304"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002336"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>positively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">positively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002215 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002215">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)</obo:IAO_0000112>
        <obo:IAO_0000112>osteoclast SubClassOf &apos;capable of&apos; some &apos;bone resorption&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. </obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has function realized in</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20123131"/>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/21208450"/>
        <obo:IAO_0000232>For compatibility with BFO, this relation has a shortcut definition in which the expression &quot;capable of some P&quot; expands to &quot;bearer_of (some realized_by only P)&quot;.</obo:IAO_0000232>
        <obo:IAO_0000424>RO_0000053 some (RO_0000054 only ?Y)</obo:IAO_0000424>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">capable of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002216 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002216">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c stands in this relationship to p if and only if there exists some p&apos; such that c is capable_of p&apos;, and p&apos; is part_of p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has function in</obo:IAO_0000118>
        <obo:IAO_0000424>RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))</obo:IAO_0000424>
        <rdfs:label xml:lang="en">capable of part of</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002222 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002222">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="https://en.wikipedia.org/wiki/Allen%27s_interval_algebra"/>
        <obo:IAO_0000232>Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.</obo:IAO_0000232>
        <terms:source rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1</terms:source>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:comment>A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.</rdfs:comment>
        <rdfs:label xml:lang="en">temporally related to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002223 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002223">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002224"/>
        <obo:IAO_0000115>Relation between occurrents, shares a start boundary with.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002223</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>starts</oboInOwl:id>
        <oboInOwl:shorthand>starts</oboInOwl:shorthand>
        <rdfs:label>starts</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002223"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Relation between occurrents, shares a start boundary with.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
        <oboInOwl:hasDbXref>Allen:starts</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002224 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002224">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <oboInOwl:hasDbXref>RO:0002224</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>starts_with</oboInOwl:id>
        <oboInOwl:shorthand>starts_with</oboInOwl:shorthand>
        <rdfs:label>starts with</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002229 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002229">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <obo:IAO_0000115>Relation between occurrents, shares an end boundary with.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002229</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>finishes</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>ends</oboInOwl:id>
        <oboInOwl:shorthand>ends</oboInOwl:shorthand>
        <rdfs:label>ends</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002229"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Relation between occurrents, shares an end boundary with.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
        <oboInOwl:hasDbXref>Allen:starts</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:finishes</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002230 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002230">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <oboInOwl:hasDbXref>RO:0002230</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>ends_with</oboInOwl:id>
        <oboInOwl:shorthand>ends_with</oboInOwl:shorthand>
        <rdfs:label>ends with</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002233 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002233">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>consumes</obo:IAO_0000118>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">has input</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002263 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002263">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.</obo:IAO_0000112>
        <obo:IAO_0000115>c acts upstream of p if and only if c enables some f that is involved in p&apos; and p&apos; occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p&apos; are processes.</obo:IAO_0000115>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002264 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002264">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002418"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.</obo:IAO_0000112>
        <obo:IAO_0000115>c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.</obo:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>affects</oboInOwl:hasRelatedSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002304 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002304">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004047"/>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <terms:creator>cjm</terms:creator>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y</rdfs:comment>
        <rdfs:label>causally upstream of, positive effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002305 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002305">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004046"/>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <terms:creator>cjm</terms:creator>
        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y</rdfs:comment>
        <rdfs:label>causally upstream of, negative effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002314 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002314">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002502"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0000052"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002314"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.</obo:IAO_0000115>
        <obo:IAO_0000116>Because part_of is transitive, inheres in is a sub-relation of inheres in part of</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20064205"/>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">inheres in part of</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002314"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0000052"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002323 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002323">
        <obo:IAO_0000115>A mereological relationship or a topological relationship</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships</obo:IAO_0000232>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">mereotopologically related to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002327 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002327">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002017"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>a particular instances of akt-2 enables some instance of protein kinase activity</obo:IAO_0000112>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>catalyzes</obo:IAO_0000118>
        <obo:IAO_0000118>executes</obo:IAO_0000118>
        <obo:IAO_0000118>has</obo:IAO_0000118>
        <obo:IAO_0000118>is catalyzing</obo:IAO_0000118>
        <obo:IAO_0000118>is executing</obo:IAO_0000118>
        <obo:IAO_0000232>This relation differs from the parent relation &apos;capable of&apos; in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.</obo:IAO_0000232>
        <obo:IAO_0000232>This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.</obo:IAO_0000232>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label xml:lang="en">enables</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002328 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002328">
        <obo:IAO_0000115>A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>This is a grouping relation that collects relations used for the purpose of connecting structure and function</obo:IAO_0000232>
        <rdfs:label xml:lang="en">functionally related to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002329 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002329">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>this relation holds between c and p when c is part of some c&apos;, and c&apos; is capable of p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</obo:IAO_0000118>
        <rdfs:label xml:lang="en">part of structure that is capable of</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002329"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:annotatedTarget>
        <obo:RO_0002581 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002581>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002331 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002331">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002431"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved_in p if and only if c enables some process p&apos;, and p&apos; is part of p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>actively involved in</obo:IAO_0000118>
        <obo:IAO_0000118>enables part of</obo:IAO_0000118>
        <rdfs:label xml:lang="en">involved in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Involved_in"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002333 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002333">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <obo:IAO_0000115>inverse of enables</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">enabled by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002334 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002334">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>inverse of regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000589>regulated by (processual)</obo:IAO_0000589>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">regulated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002335 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002335">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <obo:IAO_0000115>inverse of negatively regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">negatively regulated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002336 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002336">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <obo:IAO_0000115>inverse of positively regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">positively regulated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002352 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002352">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <obo:IAO_0000115>inverse of has input</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">input of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002371 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002371">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002176"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002177"/>
        <oboInOwl:hasDbXref>RO:0002371</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>attaches_to</oboInOwl:id>
        <oboInOwl:shorthand>attaches_to</oboInOwl:shorthand>
        <rdfs:label>attaches_to</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/FMA_85990"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002404 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002404">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>inverse of upstream of</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label xml:lang="en">causally downstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002405 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002405">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label xml:lang="en">immediately causally downstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002410 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002410">
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>This relation groups causal relations between material entities and causal relations between processes</obo:IAO_0000115>
        <obo:IAO_0000116>This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an &apos;activity flow-centric approach&apos;, with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.

To define causal relations in an activity-flow type network, we make use of 3 primitives:

 * Temporal: how do the intervals of the two occurrents relate? 
 * Is the causal relation regulatory?
 * Is the influence positive or negative

The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are &apos;direct&apos;, &apos;indirect&apos; or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under &apos;temporally related to&apos;). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.

For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.

For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.

Each of these 3 primitives can be composed to yield a cross-product of different relation types.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label xml:lang="en">causally related to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002411 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002411">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">causally upstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002412 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002412">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002090"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:label xml:lang="en">immediately causally upstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002418 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002418">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000115>p &apos;causally upstream or within&apos; q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.</obo:IAO_0000115>
        <obo:IAO_0000116>We would like to make this disjoint with &apos;preceded by&apos;, but this is prohibited in OWL2</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>influences (processual)</obo:IAO_0000118>
        <oboInOwl:hasRelatedSynonym>affects</oboInOwl:hasRelatedSynonym>
        <rdfs:label>causally upstream of or within</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002427 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002427">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000115>inverse of causally upstream of or within</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label>causally downstream of or within</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002428 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002428">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002431"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p&apos; and p&apos; regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>involved in regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002429 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002429">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p&apos; and p&apos; positively regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:label>involved in positive regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002430 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002430">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p&apos; and p&apos; negatively regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:label>involved in negative regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002431 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002431">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <obo:IAO_0000115>c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p</obo:IAO_0000115>
        <obo:IAO_0000116>OWL does not allow defining object properties via a Union</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>involved in or reguates</obo:IAO_0000118>
        <rdfs:label>involved in or involved in regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002432 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002432">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A protein that enables activity in a cytosol.</obo:IAO_0000112>
        <obo:IAO_0000115>c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>executes activity in</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>enables activity in</oboInOwl:hasExactSynonym>
        <rdfs:comment></rdfs:comment>
        <rdfs:label>is active in</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002432"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:annotatedTarget>
        <obo:RO_0002581 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002581>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002432"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:cjm</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002434 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002434">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A relationship that holds between two entities in which the processes executed by the two entities are causally connected.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">Considering relabeling as &apos;pairwise interacts with&apos;</obo:IAO_0000116>
        <obo:IAO_0000116>This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.</obo:IAO_0000232>
        <oboInOwl:hasExactSynonym>in pairwise interaction with</oboInOwl:hasExactSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>interacts with</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/MI_0914</rdfs:seeAlso>
        <foaf:page rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/oborel/obo-relations/wiki/InteractionRelations</foaf:page>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002436 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002436">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002434"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
        <obo:IAO_0000115>An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>binds</obo:IAO_0000118>
        <obo:IAO_0000118>molecularly binds with</obo:IAO_0000118>
        <rdfs:label>molecularly interacts with</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ECO_0000353"/>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/MI_0915</rdfs:seeAlso>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002447 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002447">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002436"/>
        <obo:IAO_0000116>Axiomatization to GO to be added later</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y.</obo:IAO_0000118>
        <rdfs:label>phosphorylates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002448 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002448">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002436"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011002"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.

A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <oboInOwl:hasExactSynonym>molecularly controls</oboInOwl:hasExactSynonym>
        <rdfs:label>directly regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002449 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002449">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002630"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>directly inhibits</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>molecularly decreases activity of</oboInOwl:hasExactSynonym>
        <rdfs:label>directly negatively regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002450 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002450">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002629"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>directly activates</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>molecularly increases activity of</oboInOwl:hasExactSynonym>
        <rdfs:label>directly positively regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002464 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002464">
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning.</obo:IAO_0000232>
        <rdfs:label>helper property (not for use in curation)</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002479 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002479">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>has part that occurs in</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002479"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:annotatedTarget>
        <obo:RO_0002581 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002581>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002481 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002481">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002564"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>is kinase activity</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002496 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002496">
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000062"/>
        </owl:propertyChainAxiom>
        <oboInOwl:hasDbXref>RO:0002496</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>existence_starts_during_or_after</oboInOwl:id>
        <oboInOwl:shorthand>existence_starts_during_or_after</oboInOwl:shorthand>
        <rdfs:label>existence starts during or after</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002497 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002497">
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000063"/>
        </owl:propertyChainAxiom>
        <oboInOwl:hasDbXref>RO:0002497</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>existence_ends_during_or_before</oboInOwl:id>
        <oboInOwl:shorthand>existence_ends_during_or_before</oboInOwl:shorthand>
        <rdfs:label>existence ends during or before</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002500 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002500">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002608"/>
        <obo:IAO_0000115>A relationship between a material entity and a process where the material entity has some causal role that influences the process</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>causal agent in process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002501 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002501">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115>p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label>causal relation between processes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002502 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002502">
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>depends on</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/BFO_0000169"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002503 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002503">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002502"/>
        <obo:IAO_0000115>q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2</obo:IAO_0000115>
        <obo:IAO_0000116>This relation is provided in order to support the use of relational qualities such as &apos;concentration of&apos;; for example, the concentration of C in V is a quality that inheres in V, but pertains to C.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20064205"/>
        <rdfs:label>towards</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002506 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002506">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000116>The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label>causal relation between entities</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002559 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002559">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>causally influenced by (entity-centric)</obo:IAO_0000589>
        <rdfs:label>causally influenced by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002563 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002563">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002464"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>interaction relation helper property</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29"/>
        <foaf:page rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/oborel/obo-relations/wiki/InteractionRelations</foaf:page>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002564 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002564">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002563"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>molecular interaction relation helper property</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002566 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002566">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002233"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>causally influences (entity-centric)</obo:IAO_0000589>
        <rdfs:label>causally influences</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002578 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002578">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <obo:IAO_0000115>Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly regulates (processual)</obo:IAO_0000589>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002584 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002584">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>gland SubClassOf &apos;has part structure that is capable of&apos; some &apos;secretion by cell&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>s &apos;has part structure that is capable of&apos; p if and only if there exists some part x such that s &apos;has part&apos; x and x &apos;capable of&apos; p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>has part structure that is capable of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002595 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002595">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.</obo:IAO_0000115>
        <obo:IAO_0000116>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>causal relation between material entity and a process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002596 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002596">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>pyrethroid -&gt; growth</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of regulating</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002597 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002597">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002596"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of negatively regulating</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002598 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002598">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002596"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>renin -&gt; arteriolar smooth muscle contraction</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of positively regulating</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002608 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002608">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <obo:IAO_0000115>Inverse of &apos;causal agent in process&apos;</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>process has causal agent</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002629 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002629">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <obo:IAO_0000115>Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly positively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly positively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002630 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002630">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <obo:IAO_0000115>Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly negatively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly negatively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004031 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004031">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.</obo:IAO_0000115>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-25T23:20:13Z</oboInOwl:creation_date>
        <rdfs:label>enables subfunction</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004032 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004032">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004047"/>
        </owl:propertyChainAxiom>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:49:30Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within, positive effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004033 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004033">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004046"/>
        </owl:propertyChainAxiom>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:49:51Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within, negative effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004034 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004034">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004032"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002304"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c &apos;acts upstream of, positive effect&apos; p if c is enables f, and f is causally upstream of p, and the direction of f is positive</obo:IAO_0000115>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:53:14Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of, positive effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004035 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004035">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004033"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002305"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c &apos;acts upstream of, negative effect&apos; p if c is enables f, and f is causally upstream of p, and the direction of f is negative</obo:IAO_0000115>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:53:22Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of, negative effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004046 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004046">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:55:05Z</oboInOwl:creation_date>
        <rdfs:label>causally upstream of or within, negative effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004047 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004047">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:55:19Z</oboInOwl:creation_date>
        <rdfs:label>causally upstream of or within, positive effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011002 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011002">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <obo:IAO_0000115>q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) &lt; magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>decreased_in_magnitude_relative_to</oboInOwl:id>
        <rdfs:comment>This relation is used to determine the &apos;directionality&apos; of relative qualities such as &apos;decreased strength&apos;, relative to the parent type, &apos;strength&apos;.</rdfs:comment>
        <rdfs:label>decreased_in_magnitude_relative_to</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) &lt; magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <obo:IAO_0000115>q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>different_in_magnitude_relative_to</oboInOwl:id>
        <rdfs:label>different_in_magnitude_relative_to</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <obo:IAO_0000115>q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) &gt; magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>increased_in_magnitude_relative_to</oboInOwl:id>
        <rdfs:comment>This relation is used to determine the &apos;directionality&apos; of relative qualities such as &apos;increased strength&apos;, relative to the parent type, &apos;strength&apos;.</rdfs:comment>
        <rdfs:label>increased_in_magnitude_relative_to</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) &gt; magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/pato#reciprocal_of -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/pato#reciprocal_of">
        <obo:IAO_0000115>q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>reciprocal_of</oboInOwl:id>
        <rdfs:comment>There are frequently two ways to state the same thing: we can say &apos;spermatocyte lacks asters&apos; or &apos;asters absent from spermatocyte&apos;. In this case the quality is &apos;lacking all parts of type&apos; - it is a (relational) quality of the spermatocyte, and it is with respect to instances of &apos;aster&apos;. One of the popular requirements of PATO is that it continue to support &apos;absent&apos;, so we need to relate statements which use this quality to the &apos;lacking all parts of type&apos; quality.</rdfs:comment>
        <rdfs:label>reciprocal_of</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000002">
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:IAO_0000115 xml:lang="en">An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000003">
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:IAO_0000115 xml:lang="en">An entity that has temporal parts and that happens, unfolds or develops through time.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">occurrent</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000004 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000004">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000115 xml:lang="en">A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">independent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000015 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000015">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115 xml:lang="en">An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000017 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000017">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000115 xml:lang="en">A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">realizable entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000019 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000019">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:label xml:lang="en">quality</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000020 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000020">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115 xml:lang="en">A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">specifically dependent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000023 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000023">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115 xml:lang="en">A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000040 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000040">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:IAO_0000115 xml:lang="en">An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">material entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_24431 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431">
        <obo:IAO_0000115>A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>chemical entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>CHEBI:24431</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
        <rdfs:label>chemical entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>chemical entity</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UniProt</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50906 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50906">
        <obo:IAO_0000115>A role is particular behaviour which a material entity may exhibit.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>CHEBI:50906</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
        <rdfs:label>role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0003674 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003674">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000589>molecular process</obo:IAO_0000589>
        <rdfs:label>molecular_function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0003824 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003824">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
        <rdfs:label>catalytic activity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0007610 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007610">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050896"/>
        <obo:IAO_0000115>The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-09-20T14:06:08Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0023032</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044708</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044709</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Behavior</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>behavioral response to stimulus</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>behaviour</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>behavioural response to stimulus</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single-organism behavior</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0007610</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_agr"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <rdfs:comment>1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.
2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).</rdfs:comment>
        <rdfs:label>behavior</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007610"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:ems</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jl</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:0395448956</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:20160973</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/GO_0008150 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-09-19T15:05:24Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0000004</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0007582</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044699</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Biological_process</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>biological process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>physiological process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single organism process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>single-organism process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0008150</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_aspergillus"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pombe"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
        <rdfs:comment>Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code &apos;no data&apos; (ND), is used to indicate this.</rdfs:comment>
        <rdfs:label>biological_process</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:pdt</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/GO_0016301 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016301">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0016772"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002481"/>
                <owl:hasSelf rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:hasSelf>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:label>kinase activity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0016740 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016740">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
        <rdfs:label>transferase activity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0016772 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016772">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0016740"/>
        <rdfs:label>transferase activity, transferring phosphorus-containing groups</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0050896 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050896">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <obo:IAO_0000115>Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>GO:0051869</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>physiological response to stimulus</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0050896</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_agr"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_mouse"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:comment>Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.</rdfs:comment>
        <rdfs:label>response to stimulus</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0050896"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:ai</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:bf</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/NBO_0000313 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NBO_0000313">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0007610"/>
        <obo:IAO_0000115>&quot;The action, reaction, or performance of an organism in response to external or internal stimuli.&quot; [GO:GO\:0007610]</obo:IAO_0000115>
        <dc:date>2011-04-05T09:53:10Z</dc:date>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:hasAlternativeId>NBO:0000000</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>behavior</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>behaviour</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>behavior_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:xref>GO:0007610</oboInOwl:xref>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">behavior process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NBO_0001786 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NBO_0001786">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NBO_0000313"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NBO_0000313"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NBO_0000313"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>&quot;Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.&quot; [GO:0050795]</obo:IAO_0000115>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:xref>GO:0050795</oboInOwl:xref>
        <rdfs:label xml:lang="en">regulation of behavior</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000001">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000115>A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities</obo:IAO_0000115>
        <obo:IAO_0000589>quality (PATO)</obo:IAO_0000589>
        <oboInOwl:hasAlternativeId>PATO:0000072</oboInOwl:hasAlternativeId>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000001</oboInOwl:id>
        <rdfs:label>quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000014 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000014">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001300"/>
        <obo:IAO_0000115>A composite chromatic quality composed of hue, saturation and intensity parts.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0000020</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>colour</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>relative color</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000014</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>color</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000014"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A composite chromatic quality composed of hue, saturation and intensity parts.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000040 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000040">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <obo:IAO_0000115>A quality that is the extent of space between two entities.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000040</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#scalar_slim"/>
        <rdfs:label>distance</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000040"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality that is the extent of space between two entities.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000051 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000051">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <obo:IAO_0000115>A quality of a single physical entity inhering in the bearer by virtue of the bearer&apos;s size or shape or structure.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000051</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>morphology</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a single physical entity inhering in the bearer by virtue of the bearer&apos;s size or shape or structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000052 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000052">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <obo:IAO_0000115>A morphological quality inhering in a bearer by virtue of the bearer&apos;s ratios of distances between its features (points, edges, surfaces and also holes etc).</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0001647</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>relational shape quality</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000052</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:comment>Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.</rdfs:comment>
        <rdfs:label>shape</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000052"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A morphological quality inhering in a bearer by virtue of the bearer&apos;s ratios of distances between its features (points, edges, surfaces and also holes etc).</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000068 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000068">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000068</oboInOwl:id>
        <rdfs:comment>TODO: define this or obsolete it and move children somewhere else.</rdfs:comment>
        <rdfs:label>qualitative</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000069 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000069">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000068"/>
        <obo:IAO_0000115>A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000069</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>deviation (from_normal)</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000070 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000070">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000068"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0001555"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The number of entities of this type that are part of the whole organism.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0000053</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0000071</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0001169</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0001226</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>presence or absence in organism</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quantitative</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>count in organism</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>number</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>presence</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000070</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:comment>This term was originally named &quot;presence&quot;. It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10.</rdfs:comment>
        <rdfs:label>amount</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000070"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The number of entities of this type that are part of the whole organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000117 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000117">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <obo:IAO_0000115>A morphology quality inhering in a bearer by virtue of the bearer&apos;s physical magnitude.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000117</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#scalar_slim"/>
        <rdfs:label>size</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000117"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A morphology quality inhering in a bearer by virtue of the bearer&apos;s physical magnitude.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WordNet:WordNet</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000125 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000125">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <obo:IAO_0000115>A physical quality that inheres in a bearer by virtue of the proportion of the bearer&apos;s amount of matter.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000125</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#scalar_slim"/>
        <rdfs:label>mass</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000125"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A physical quality that inheres in a bearer by virtue of the proportion of the bearer&apos;s amount of matter.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000161 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000161">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002062"/>
        <obo:IAO_0000115>A quality of a single process inhering in a bearer by virtue of the bearer&apos;s occurrence per unit time.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000161</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#scalar_slim"/>
        <rdfs:label>rate</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000161"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a single process inhering in a bearer by virtue of the bearer&apos;s occurrence per unit time.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:melissa</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000374 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000374">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000040"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000040"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <obo:IAO_0000115>A distance which is greater relative to the normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000375"/>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>long distance</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000374</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>increased distance</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000374"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A distance which is greater relative to the normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000375 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000375">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000040"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000040"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <obo:IAO_0000115>A distance which is lesser relative to the normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000374"/>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>short distance</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000375</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>decreased distance</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000375"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A distance which is lesser relative to the normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000461 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000461">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000068"/>
        <obo:IAO_0000115>A quality inhering in a bearer by virtue of the bearer&apos;s exhibiting no deviation from normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000460"/>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>average</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000461</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#abnormal_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#mpath_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>normal</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality inhering in a bearer by virtue of the bearer&apos;s exhibiting no deviation from normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000462 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000462">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000070"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0001558"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0002000"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/PATO_0000467"/>
        <obo:IAO_0000115>A quality denoting the lack of an entity.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000467"/>
        <oboInOwl:hasAlternativeId>PATO:0001996</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>absence</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>absent from organism</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000462</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#absent_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#mpath_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:comment>See documentation here: http://code.google.com/p/phenotype-ontologies/wiki/ModelingOfAbsence</rdfs:comment>
        <rdfs:label>absent</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000462"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality denoting the lack of an entity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">thefreedictionary.:thefreedictionary.</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000467 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000467">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000070"/>
        <obo:IAO_0000115>A quality inhering in a bearer by virtue of the bearer&apos;s existence.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000462"/>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>present in organism</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000467</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#absent_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>present</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000467"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality inhering in a bearer by virtue of the bearer&apos;s existence.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000470 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000470">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000070"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000467"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
        <obo:IAO_0000115>An amount which is relatively high.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0001997"/>
        <oboInOwl:hasAlternativeId>PATO:0000420</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0000650</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>increased number</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>present in greater numbers in organism</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>supernumerary</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>accessory</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>increased</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000470</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>increased amount</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000470"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An amount which is relatively high.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000586 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000586">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000117"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000117"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <obo:IAO_0000115>A size quality which is relatively high.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000587"/>
        <oboInOwl:hasAlternativeId>PATO:0001202</oboInOwl:hasAlternativeId>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>big</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>enlarged</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>expanded</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>great</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>large</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000586</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>increased size</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000586"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A size quality which is relatively high.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000587 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000587">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000117"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000117"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <obo:IAO_0000115>A size quality which is relatively low.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000586"/>
        <oboInOwl:hasNarrowSynonym>hypoplasia</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>underdeveloped</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>reduced</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>small</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>tiny</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0000587</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>decreased size</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000587"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A size quality which is relatively low.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000911 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000911">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000161"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000161"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002302"/>
        <obo:IAO_0000115>A rate which is relatively low.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000912"/>
        <oboInOwl:hasExactSynonym>slow rate</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000911</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#mpath_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>decreased rate</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000911"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A rate which is relatively low.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATO:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000912 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000912">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000161"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000161"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002304"/>
        <obo:IAO_0000115>A rate which is relatively high.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000911"/>
        <oboInOwl:hasExactSynonym>fast rate</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>high rate</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000912</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#mpath_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>increased rate</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000912"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A rate which is relatively high.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATO:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001018 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001018">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <obo:IAO_0000115>A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0002079</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Physical_property</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>relational physical quality</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001018</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>physical quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001236 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001236">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <obo:IAO_0000115>A quality which inheres in an process.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0001239</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0001240</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>quality of a process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of occurrent</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>relational quality of occurrent</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001236</oboInOwl:id>
        <rdfs:comment>See comments of relational quality of a physical entity.</rdfs:comment>
        <rdfs:label>process quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001236"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality which inheres in an process.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001241 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001241">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <obo:IAO_0000115>A quality which inheres in a continuant.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0001237</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0001238</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>snap:Quality</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>monadic quality of a continuant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>multiply inhering quality of a physical entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of a continuant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of a single physical entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of an object</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of continuant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>monadic quality of an object</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>monadic quality of continuant</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001241</oboInOwl:id>
        <rdfs:comment>Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.</rdfs:comment>
        <rdfs:label>physical object quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality which inheres in a continuant.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001291 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001291">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001739"/>
        <obo:IAO_0000115>A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001291</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>electromagnetic (EM) radiation quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001291"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>Wikipedia:http://en.wikipedia.org/wiki/Electromagnetic_radiation</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001300 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001300">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001291"/>
        <obo:IAO_0000115>An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001300</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>optical quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001300"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001555 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001555">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000070"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>OBO_REL:has_part</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>extra or missing physical or functional parts</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>has or lacks parts of type</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>mereological quality</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>number of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>cardinality</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>number</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0001555</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:label>has number of</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001555"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001558 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001558">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001564"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000462"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A quality of a process inhering in a bearer by virtue of the bearer&apos;s lacking a processual part as specified by the additional entity.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001558</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>lacking processual parts</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001558"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a process inhering in a bearer by virtue of the bearer&apos;s lacking a processual part as specified by the additional entity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001562 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001562">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000125"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000125"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <obo:IAO_0000115>A mass which is lower than normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0001563"/>
        <oboInOwl:hasAlternativeId>PATO:0000579</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>low mass</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>small mass</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001562</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>decreased mass</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001562"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A mass which is lower than normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATO:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001563 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001563">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000125"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000125"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <obo:IAO_0000115>A mass which is higher than normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0001562"/>
        <oboInOwl:hasAlternativeId>PATO:0000578</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>high mass</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>large mass</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001563</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>increased mass</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001563"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A mass which is higher than normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATO:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001564 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001564">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001236"/>
        <obo:IAO_0000115>A quality of a process inhering in a bearer by virtue of the bearer&apos;s processual parts.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001564</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:label>extra or missing processual parts</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001564"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a process inhering in a bearer by virtue of the bearer&apos;s processual parts.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001739 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001739">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <obo:IAO_0000115>A quality that inheres in an bearer by virtue of how that bearer interacts with radiation.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001739</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>radiation quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001739"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality that inheres in an bearer by virtue of how that bearer interacts with radiation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001997 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001997">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000070"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000467"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002301"/>
        <obo:IAO_0000115>An amount which is relatively low.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0000470"/>
        <oboInOwl:hasAlternativeId>PATO:0000419</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0000468</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>decreased number</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>present in fewer numbers in organism</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>decreased</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>reduced</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>subnumerary</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>PATO:0001997</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#value_slim"/>
        <rdfs:label>decreased amount</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001997"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An amount which is relatively low.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001999 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001999">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002083"/>
        <obo:IAO_0000115>The bearer of this quality has_part &lt; n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is &lt; n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>loss of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001999</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:label>lacks parts or has fewer parts of type</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001999"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The bearer of this quality has_part &lt; n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is &lt; n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002000">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001999"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#reciprocal_of"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000462"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A quality of physical entities inhering in a bearer by virtue of the bearer&apos;s lacking a physical part as specified by the additional entity.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0001557</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>OBO_REL:lacks_part</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>lacks all physical parts of type</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002000</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:comment>Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2.</rdfs:comment>
        <rdfs:label>lacks all parts of type</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002000"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of physical entities inhering in a bearer by virtue of the bearer&apos;s lacking a physical part as specified by the additional entity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002001">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0001999"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001999"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <obo:IAO_0000115>The bearer of this quality has_part &lt; n AND has_part &gt; 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is &lt; n, where n is either the normal number for comparable entities, or n is stated explicitly.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002002"/>
        <oboInOwl:hasAlternativeId>PATO:0001569</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>decreased number of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>has decreased number of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>has fewer physical parts of type</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002001</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:comment>Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type.</rdfs:comment>
        <rdfs:label>has fewer parts of type</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002001"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The bearer of this quality has_part &lt; n AND has_part &gt; 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is &lt; n, where n is either the normal number for comparable entities, or n is stated explicitly.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002002">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0002083"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002083"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <obo:IAO_0000115>The bearer of this quality has_part &gt; n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002001"/>
        <oboInOwl:hasAlternativeId>PATO:0001560</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>has extra parts of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>has increased number of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>having extra physical parts</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>having supernumerary physical parts</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>increased number of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002002</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:comment>In polydactyly, the bearer of the quality is the hand, and the entity type being counted is &apos;finger&apos;. In EQ syntax, E=hand, Q=&lt;this&gt; E2=finger.</rdfs:comment>
        <rdfs:label>has extra parts of type</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The bearer of this quality has_part &gt; n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002062 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002062">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001236"/>
        <oboInOwl:created_by>george</oboInOwl:created_by>
        <oboInOwl:creation_date>2009-06-05T09:16:46Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002062</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>physical quality of a process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002083 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002083">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001555"/>
        <obo:IAO_0000115>Having extra or fewer parts.</obo:IAO_0000115>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2009-09-21T10:41:58Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002083</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#relational_slim"/>
        <rdfs:label>altered number of</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002083"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Having extra or fewer parts.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002300 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002300">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000001"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A quality that has a value that is increased compared to normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002301"/>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2011-06-16T06:39:43Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002300</oboInOwl:id>
        <rdfs:label>increased quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality that has a value that is increased compared to normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002301 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002301">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0000001"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A quality that has a value that is decreased compared to normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2011-06-16T06:40:15Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002301</oboInOwl:id>
        <rdfs:label>decreased quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002301"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality that has a value that is decreased compared to normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002302 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002302">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0001236"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001236"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002301"/>
        <obo:IAO_0000115>A quality of a process that has a value that is decreased compared to normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002304"/>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2011-06-16T06:50:59Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002302</oboInOwl:id>
        <rdfs:label>decreased process quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002302"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a process that has a value that is decreased compared to normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002303 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002303">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0001241"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#decreased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002301"/>
        <obo:IAO_0000115>A quality of an object that has a value that is decreased compared to normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2011-06-16T06:51:54Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002303</oboInOwl:id>
        <rdfs:label>decreased object quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of an object that has a value that is decreased compared to normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002304 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002304">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0001236"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001236"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
        <obo:IAO_0000115>A quality of a process that has a value that is increased compared to normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002302"/>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2011-06-16T06:53:08Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002304</oboInOwl:id>
        <rdfs:label>increased process quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002304"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a process that has a value that is increased compared to normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002305 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002305">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PATO_0001241"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000461"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
        <obo:IAO_0000115>A quality of an object that has a value that is increased compared to normal or average.</obo:IAO_0000115>
        <obo:RO_0002604 rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:creation_date>2011-06-16T06:54:01Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0002305</oboInOwl:id>
        <rdfs:label>increased object quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of an object that has a value that is increased compared to normal or average.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000000">
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <obo:IAO_0000115>An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000000</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>processual entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>span:ProcessualEntity</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000061 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000061">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002496"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002497"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism&apos;s own genome.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://dbpedia.org/ontology/AnatomicalStructure"/>
        <oboInOwl:hasDbXref rdf:resource="http://www.snomedbrowser.com/Codes/Details/362889002"/>
        <oboInOwl:hasDbXref>AAO:0010825</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>AEO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BILA:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CARO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA2:0003003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EMAPA:0</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00007001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:305751</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:67135</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GAID:781</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HAO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MA:0003000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D000825</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TAO:0000037</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TGMA:0001823</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0001759</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:0003000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFA:0000037</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>biological structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>connected biological structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000061</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>anatomical structure</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism&apos;s own genome.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>CARO:0000003</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>connected biological structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref>CARO:0000003</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000066 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000066">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000111"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.</obo:IAO_0000115>
        <oboInOwl:hasBroadSynonym>adult stage</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>BTO:0001043</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001272</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005369</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000041</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XtroDO:0000084</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>fully formed animal stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>juvenile-adult stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000066</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>fully formed stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/566</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000066"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000068 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000068">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000066"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
        <obo:IAO_0000115>A life cycle stage that starts with fertilization and ends with the fully formed embryo.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://www.snomedbrowser.com/Codes/Details/296280003"/>
        <oboInOwl:hasDbXref>BilaDO:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EV:0300001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005289</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:72652</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000022</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000092</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000102</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000012</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>embryonic stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>embryogenesis</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000068</oboInOwl:id>
        <rdfs:label>embryo stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A life cycle stage that starts with fertilization and ends with the fully formed embryo.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000071 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000071">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002229"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>End of the life of an organism.</obo:IAO_0000115>
        <obo:UBPROP_0000012>ncit:Death is an outcome</obo:UBPROP_0000012>
        <oboInOwl:hasDbXref>XAO:0000437</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XtroDO:0000085</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>death</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000071</oboInOwl:id>
        <rdfs:label>death stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>End of the life of an organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>XAO:0000437</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/UBPROP_0000012"/>
        <owl:annotatedTarget>ncit:Death is an outcome</owl:annotatedTarget>
        <oboInOwl:external_ontology>ncit</oboInOwl:external_ontology>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000092 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000092">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>stage succeeding embryo, including mature structure</obo:IAO_0000115>
        <obo:UBPROP_0000008>In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)</obo:UBPROP_0000008>
        <oboInOwl:hasDbXref>BilaDO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000014</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000024</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000022</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000093</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000103</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>postembryonic stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>post-hatching stage</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>postembryonic</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000092</oboInOwl:id>
        <rdfs:label>post-embryonic stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/344</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>stage succeeding embryo, including mature structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000104 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000104">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002224"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002230"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>An entire span of an organism&apos;s life, commencing with the zygote stage and ending in the death of the organism.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>FBdv:00000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000011</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ncithesaurus:Life</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>entire life cycle</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>entire lifespan</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>life</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>lifespan</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000104</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>life cycle</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/532</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An entire span of an organism&apos;s life, commencing with the zygote stage and ending in the death of the organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000105 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000105">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A spatiotemporal region encompassing some part of the life cycle of an organism.</obo:IAO_0000115>
        <obo:IAO_0000116>this class represents a proper part of the life cycle of an organism. The class &apos;life cycle&apos; should not be placed here</obo:IAO_0000116>
        <obo:UBPROP_0000012>the WBls class &apos;all stages&apos; belongs here as it is the superclass of other WBls stages</obo:UBPROP_0000012>
        <obo:UBPROP_0000012>we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage</obo:UBPROP_0000012>
        <oboInOwl:hasDbXref>BILS:0000105</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0000399</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00007012</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:24120</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OlatDv:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PdumDv:0000090</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0100000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ncithesaurus:Developmental_Stage</oboInOwl:hasDbXref>
        <oboInOwl:hasNarrowSynonym>developmental stage</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>stage</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000105</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>life cycle stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A spatiotemporal region encompassing some part of the life cycle of an organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000106 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000106">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002223"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A stage at which the organism is a single cell produced by means of sexual reproduction.</obo:IAO_0000115>
        <obo:UBPROP_0000003>As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]</obo:UBPROP_0000003>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Zygote"/>
        <oboInOwl:hasDbXref>BILS:0000106</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001322</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA:27</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005288</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NCIT:C12601</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PdumDv:0000100</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0000745</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>1-cell stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>fertilized egg stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>one cell stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>fertilized egg stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>one-cell stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>zygote</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>zygotum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000106</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>zygote stage</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/EMAPA_16033"/>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A stage at which the organism is a single cell produced by means of sexual reproduction.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Zygote"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/UBPROP_0000003"/>
        <owl:annotatedTarget>As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]</owl:annotatedTarget>
        <oboInOwl:date_retrieved rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012-09-17</oboInOwl:date_retrieved>
        <oboInOwl:external_class>VHOG:0000745</oboInOwl:external_class>
        <oboInOwl:ontology rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VHOG</oboInOwl:ontology>
        <oboInOwl:source rdf:resource="http://bgee.unil.ch/"/>
        <oboInOwl:source>ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107</oboInOwl:source>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>fertilized egg stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref>BTO:0000854</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>one-cell stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref>VHOG:0000745</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>zygote</owl:annotatedTarget>
        <oboInOwl:hasDbXref>VHOG:0000745</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>zygotum</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Zygote"/>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/uberon/core#LATIN"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000107 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000107">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Cleavage_(embryo)"/>
        <oboInOwl:hasDbXref>BILS:0000107</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001290</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00000054</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:A16.254.270</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000015</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000020</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PdumDv:0000200</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000046</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000107</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>cleavage stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000107"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Cleavage_(embryo)"/>
        <oboInOwl:hasDbXref>GO:0040016</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000108 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000108">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000107"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.</obo:IAO_0000115>
        <obo:IAO_0000116>consider adding a preceding stage &apos;morula stage&apos; as part of cleavage</obo:IAO_0000116>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Blastula"/>
        <oboInOwl:hasDbXref>BILS:0000108</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000007</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001282</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000007</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000016</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000021</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000045</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000108</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>blastula stage</rdfs:label>
        <foaf:depicted_by rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png</foaf:depicted_by>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000108"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Blastula"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000109 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000109">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000108"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BILS:0000109</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000008</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001296</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005317</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000013</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000019</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000047</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>blastocystis trilaminaris stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar blastocyst stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar blastoderm stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar disk stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar germ stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000109</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>gastrula stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2000/01/rdf-schema#subClassOf"/>
        <owl:annotatedTarget>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000108"/>
            </owl:Restriction>
        </owl:annotatedTarget>
        <oboInOwl:source>BILS</oboInOwl:source>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GO:0007369</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>blastocystis trilaminaris stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>trilaminar blastocyst stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>trilaminar blastoderm stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>trilaminar disk stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>trilaminar germ stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>trilaminar stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000110 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000110">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BILS:0000110</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000009</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000012</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000017</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000006</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000110</oboInOwl:id>
        <rdfs:label>neurula stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/343</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000110"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GO:0001841</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000111 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000111">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000110"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Organogenesis"/>
        <oboInOwl:hasDbXref>BILS:0000111</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000015</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000018</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000032</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>segmentation stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000111</oboInOwl:id>
        <rdfs:label>organogenesis stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/533</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000111"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Organogenesis"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0000465 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000465">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <obo:IAO_0000115>Anatomical entity that has mass.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>AAO:0010264</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>AEO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BILA:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CARO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA2:0003006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00007016</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:67165</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HAO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TAO:0001836</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TGMA:0001826</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0001721</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000465</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>material anatomical entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Anatomical entity that has mass.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0001-9114-8737"/>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001062 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001062">
        <obo:IAO_0000115>Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://linkedlifedata.com/resource/umls/id/C1515976"/>
        <oboInOwl:hasDbXref>AAO:0010841</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>AEO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BILA:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BIRNLEX:6</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CARO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA2:0002229</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:10000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt_root:00000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:62955</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HAO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MA:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NCIT:C12219</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TAO:0100000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TGMA:0001822</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>UMLS:C1515976</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBbt:0000100</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFA:0100000</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0001062</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>anatomical entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0001-9114-8737"/>
        <oboInOwl:hasDbXref>FMA:62955</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
        <owl:annotatedTarget>UMLS:C1515976</owl:annotatedTarget>
        <oboInOwl:source>ncithesaurus:Anatomic_Structure_System_or_Substance</oboInOwl:source>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0010000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010000">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <obo:IAO_0000115>An anatomical structure that has more than one cell as a part.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>CARO:0010000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00100313</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>multicellular structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0010000</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>multicellular anatomical structure</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0010000"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An anatomical structure that has more than one cell as a part.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>CARO:0010000</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0010000"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>multicellular structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref>FBbt:00100313</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // General axioms
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <owl:Class>
        <owl:unionOf rdf:parseType="Collection">
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </owl:unionOf>
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </owl:equivalentClass>
    </owl:Class>
    <owl:Restriction>
        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
                        <owl:someValuesFrom>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                            </owl:Restriction>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
                        <owl:someValuesFrom>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
                                <owl:someValuesFrom>
                                    <owl:Restriction>
                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
                                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                                    </owl:Restriction>
                                </owl:someValuesFrom>
                            </owl:Restriction>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                </owl:unionOf>
            </owl:Class>
        </rdfs:subClassOf>
    </owl:Restriction>
    <owl:Restriction>
        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </owl:disjointWith>
    </owl:Restriction>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Rules
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <rdf:Description rdf:about="urn:swrl#w">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#p">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ro.owl#z">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ro.owl#y">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ro.owl#x">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#y">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#x">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#z">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#a1">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#a2">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#g1">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#g2">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#B">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#C">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#A">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#D">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#mf">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#eff">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#in">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#mf2">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002180"/>
                        <swrl:argument1 rdf:resource="urn:swrl#w"/>
                        <swrl:argument2 rdf:resource="urn:swrl#p"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                                <swrl:argument1 rdf:resource="urn:swrl#w"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                        <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#p"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002018"/>
                        <swrl:argument1 rdf:resource="urn:swrl#w"/>
                        <swrl:argument2 rdf:resource="urn:swrl#p"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <swrla:isRuleEnabled rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</swrla:isRuleEnabled>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MF(X)-directly_regulates-&gt;MF(Y)-enabled_by-&gt;GP(Z) =&gt; MF(Y)-has_input-&gt;GP(Y) e.g. if &apos;protein kinase activity&apos;(X) directly_regulates &apos;protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">infer input from direct reg</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                        <swrl:argument1 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#z"/>
                        <swrl:argument2 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                                <swrl:argument1 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#x"/>
                                <swrl:argument2 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                        <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
                                        <swrl:argument1 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#x"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                        <rdf:first>
                                            <rdf:Description>
                                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                                <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
                                                <swrl:argument1 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#y"/>
                                            </rdf:Description>
                                        </rdf:first>
                                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                                    </rdf:Description>
                                </rdf:rest>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                        <swrl:argument1 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#x"/>
                        <swrl:argument2 rdf:resource="http://purl.obolibrary.org/obo/ro.owl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>GP(X)-enables-&gt;MF(Y)-has_part-&gt;MF(Z) =&gt; GP(X) enables MF(Z),
e.g.  if GP X enables ATPase coupled transporter activity&apos; and &apos;ATPase coupled transporter activity&apos; has_part &apos;ATPase activity&apos; then GP(X) enables &apos;ATPase activity&apos;</rdfs:comment>
        <rdfs:label>enabling an MF enables its parts</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <swrla:isRuleEnabled rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</swrla:isRuleEnabled>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GP(X)-enables-&gt;MF(Y)-part_of-&gt;BP(Z) =&gt; GP(X) involved_in BP(Z) e.g. if X enables &apos;protein kinase activity&apos; and Y &apos;part of&apos; &apos;signal tranduction&apos; then X involved in &apos;signal transduction&apos;</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">involved in BP</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
                        <swrl:argument1 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002331"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#a1"/>
                        <swrl:argument2 rdf:resource="urn:swrl#a2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0016301"/>
                                <swrl:argument1 rdf:resource="urn:swrl#a1"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#a1"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#g1"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                        <rdf:first>
                                            <rdf:Description>
                                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                                <swrl:argument1 rdf:resource="urn:swrl#a2"/>
                                                <swrl:argument2 rdf:resource="urn:swrl#g2"/>
                                            </rdf:Description>
                                        </rdf:first>
                                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                                    </rdf:Description>
                                </rdf:rest>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002447"/>
                        <swrl:argument1 rdf:resource="urn:swrl#g1"/>
                        <swrl:argument2 rdf:resource="urn:swrl#g2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>This rule is dubious: added as a quick fix for expected inference in GO-CAM.  The problem is most acute for transmembrane proteins, such as receptors or cell adhesion molecules, which have some subfunctions inside the cell (e.g. kinase activity) and some subfunctions outside (e.g. ligand binding).  Correct annotation of where these functions occurs leads to incorrect inference about the location of the whole protein.  This should probably be weakened to &quot;... -&gt; overlaps&quot;</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X.  Note:  this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.</rdfs:comment>
        <rdfs:label>inferring direct reg edge from input to regulatory subfunction</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
                        <swrl:argument1 rdf:resource="urn:swrl#B"/>
                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                <swrl:argument1 rdf:resource="urn:swrl#A"/>
                                <swrl:argument2 rdf:resource="urn:swrl#B"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002013"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#D"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#A"/>
                        <swrl:argument2 rdf:resource="urn:swrl#D"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>inferring direct neg reg edge from input to regulatory subfunction</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
                        <swrl:argument1 rdf:resource="urn:swrl#B"/>
                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                <swrl:argument1 rdf:resource="urn:swrl#A"/>
                                <swrl:argument2 rdf:resource="urn:swrl#B"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002014"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#D"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
                        <swrl:argument1 rdf:resource="urn:swrl#A"/>
                        <swrl:argument2 rdf:resource="urn:swrl#D"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>inferring direct positive reg edge from input to regulatory subfunction</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
                        <swrl:argument1 rdf:resource="urn:swrl#B"/>
                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                <swrl:argument1 rdf:resource="urn:swrl#A"/>
                                <swrl:argument2 rdf:resource="urn:swrl#B"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002015"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#D"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
                        <swrl:argument1 rdf:resource="urn:swrl#A"/>
                        <swrl:argument2 rdf:resource="urn:swrl#D"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>effector input is compound function input</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                                <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                                <swrl:argument2 rdf:resource="urn:swrl#in"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#in"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>Input of effector is input of its parent MF</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#in"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#in"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>if effector directly regulates X,  its parent MF directly regulates X</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>if effector directly positively regulates X,  its parent MF directly positively regulates X</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>if effector directly negatively regulates X,  its parent MF directly negatively regulates X</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>&apos;causally downstream of&apos; and &apos;overlaps&apos; should be disjoint properties (a SWRL rule is required because these are non-simple properties).</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>&apos;causally upstream of&apos; and &apos;overlaps&apos; should be disjoint properties (a SWRL rule is required because these are non-simple properties).</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
</rdf:RDF>



<!-- Generated by the OWL API (version 4.5.6) https://github.com/owlcs/owlapi -->

