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        "identifier" : "IAO_0000602",
        "language" : "undefined",
        "value" : "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] ",
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        "language" : "undefined",
        "value" : "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] ",
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    "comment" : {
      "undefined" : "per discussion with Barry Smith"
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        "language" : "en",
        "value" : "your body mass index",
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        "language" : "en",
        "value" : "the Second World War",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "Verdi’s Requiem",
        "type" : "label"
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      }, {
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      "en" : "entity"
    },
    "subClasses" : [ "74", "75" ],
    "comment" : {
      "undefined" : "per discussion with Barry Smith"
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        "language" : "en",
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        "value" : "CARO:0000013",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "CARO_0000013",
      "undefined" : "cell"
    },
    "subClasses" : [ "264" ],
    "comment" : {
      "undefined" : "deprecate and replace with CL or GO term?"
    },
    "attributes" : [ "equivalent", "external" ],
    "id" : "265",
    "superClasses" : [ "158", "167" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/CARO_0000004",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
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        "identifier" : "IAO_0000112",
        "language" : "undefined",
        "value" : "Examples include feces, urine, blood, blood plasma, lymph, hemolymph, cerbro-spinal fluid.  This class does not encompass anatomical entities with inherent 3D structure such as dentine and arthropod cuticle.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "portion of organism substance",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body and that does not have inherent 3D shape generated by coordinated expression of the organism's own genome.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "CARO:0000004",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "CARO_0000004",
      "undefined" : "organism substance"
    },
    "comment" : {
      "undefined" : "Note - CARO explicitly declares organisms substances to be part of (some) organism."
    },
    "attributes" : [ "external" ],
    "id" : "43",
    "superClasses" : [ "44" ]
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    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
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    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "An abnormally formed/malformed 'anatomical entity' in 'independent continuant'.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "malformed 'anatomical entity' in 'independent continuant'",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "malformedAnatomicalEntityInLocation",
        "type" : "label"
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    },
    "label" : {
      "IRI-based" : "malformedAnatomicalEntityInLocation.yaml",
      "undefined" : "abnormally formed 'anatomical entity' in 'independent continuant'"
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    "id" : "592",
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        "identifier" : "IAO_0000115",
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        "type" : "label"
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      "hasExactSynonym" : [ {
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        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "molecular_function",
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      "IAO_0000589" : [ {
        "identifier" : "IAO_0000589",
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        "value" : "molecular process",
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      "id" : [ {
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      "inSubset" : [ {
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        "identifier" : "inSubset",
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        "identifier" : "inSubset",
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        "identifier" : "inSubset",
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      "hasAlternativeId" : [ {
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        "value" : "GO:0005554",
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      "undefined" : "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code \"no data\" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex."
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    "attributes" : [ "external" ],
    "id" : "142",
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    "instances" : 0,
    "annotations" : {
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        "value" : "Anatomical entity that has no mass.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
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    "intersection" : [ "116" ],
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    "instances" : 0,
    "annotations" : {
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      "id" : [ {
        "identifier" : "id",
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    "label" : {
      "IRI-based" : "CARO_0000040",
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    "intersection" : [ "167" ],
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      "undefined" : "Example.  Insect cuticle, eggshell, hair."
    },
    "attributes" : [ "intersection", "external" ],
    "id" : "49",
    "superClasses" : [ "44", "167" ]
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        "type" : "label"
      } ],
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      "undefined" : "MH: define as not part of embryo, or will not develop into embryo? MH: changed def to exclude cells so this class could be included in gross anatomical part. DOS: Changed to something that I think works for both vertebrates and invertebrates and that keeps the restriction to multicellular structures.  Old def: \"Anatomical structure that is contiguous with the embryo and is comprised of portions of tissue that will not contribute to the embryo.\".  One remaining question - perhaps zygote is too restrictive given that some organisms have parthenogenesis e.g. aphids?\n"
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      "undefined" : "abnormal incomplete closing of the 'anatomical entity'"
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    "superClasses" : [ "331", "332" ]
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        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "of one-sided specifically dependent continuants: the mass of this tomato",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the smell of this portion of mozzarella",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the function of this heart: to pump blood",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the pink color of a medium rare piece of grilled filet mignon at its center",
        "type" : "label"
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        "identifier" : "IAO_0000112",
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        "value" : "the mutual dependence of proton donors and acceptors in chemical reactions [79",
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        "identifier" : "IAO_0000112",
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        "value" : "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
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        "value" : "the shape of this hole.",
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      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the disposition of this fish to decay",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the role of being a doctor",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.",
        "type" : "label"
      } ],
      "isDefinedBy" : [ {
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        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo.owl",
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        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1  i &lt; j  n, ci  and cj share no common parts, are such that for each 1  i  n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.",
        "type" : "label"
      } ],
      "BFO_0000179" : [ {
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        "value" : "sdc",
        "type" : "label"
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      "IAO_0000602" : [ {
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        "type" : "label"
      }, {
        "identifier" : "IAO_0000602",
        "language" : "undefined",
        "value" : "(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] ",
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      } ],
      "IAO_0010000" : [ {
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      }, {
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        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo/axiom/050-003",
        "type" : "iri"
      } ]
    },
    "label" : {
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    },
    "subClasses" : [ "482", "402", "258", "56", "46", "459", "270", "465", "420", "296", "426", "379", "383", "386", "391" ],
    "comment" : {
      "undefined" : "per discussion with Barry Smith"
    },
    "attributes" : [ "external" ],
    "id" : "57",
    "superClasses" : [ "74" ]
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    "instances" : 0,
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        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the role of subject in a clinical trial",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the priest role",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the role of a boundary to demarcate two neighboring administrative territories",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the role of a stone in marking a property boundary",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the role of a building in serving as a military target",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the student role",
        "type" : "label"
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        "type" : "label"
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        "language" : "en",
        "value" : "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives.",
        "type" : "label"
      } ],
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        "language" : "en",
        "value" : "b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])",
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      "IAO_0000602" : [ {
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        "language" : "undefined",
        "value" : "(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] ",
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      } ],
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        "value" : "a forest fire",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "a human being",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "an aggregate of human beings.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the undetached arm of a human being",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "an epidemic",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "an energy wave",
        "type" : "label"
      } ],
      "isDefinedBy" : [ {
        "identifier" : "isDefinedBy",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo.owl",
        "type" : "iri"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.",
        "type" : "label"
      } ],
      "IAO_0000601" : [ {
        "identifier" : "IAO_0000601",
        "language" : "en",
        "value" : "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000601",
        "language" : "en",
        "value" : "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "bfo",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.",
        "type" : "label"
      } ],
      "IAO_0000600" : [ {
        "identifier" : "IAO_0000600",
        "language" : "en",
        "value" : "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])",
        "type" : "label"
      } ],
      "BFO_0000179" : [ {
        "identifier" : "BFO_0000179",
        "language" : "undefined",
        "value" : "material",
        "type" : "label"
      } ],
      "IAO_0000602" : [ {
        "identifier" : "IAO_0000602",
        "language" : "undefined",
        "value" : "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] ",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000602",
        "language" : "undefined",
        "value" : "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] ",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000602",
        "language" : "undefined",
        "value" : "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] ",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "BFO:0000040",
        "type" : "label"
      } ],
      "IAO_0010000" : [ {
        "identifier" : "IAO_0010000",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo/axiom/021-002",
        "type" : "iri"
      }, {
        "identifier" : "IAO_0010000",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo/axiom/020-002",
        "type" : "iri"
      }, {
        "identifier" : "IAO_0010000",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo/axiom/019-002",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000040",
      "en" : "material entity",
      "undefined" : "material entity"
    },
    "subClasses" : [ "487", "19", "11" ],
    "attributes" : [ "external" ],
    "id" : "69",
    "superClasses" : [ "171" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/CARO_0000000",
    "equivalent" : [ "96" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "CAROC:Brownsville2014",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex.  Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/caro.owl",
        "type" : "iri"
      } ],
      "IAO_0000589" : [ {
        "identifier" : "IAO_0000589",
        "language" : "undefined",
        "value" : "anatomical entity (CARO)",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "CARO:0000000",
        "type" : "label"
      } ]
    },
    "disjointUnion" : [ "18", "19" ],
    "label" : {
      "IRI-based" : "CARO_0000000",
      "en" : "anatomical entity",
      "undefined" : "anatomical entity"
    },
    "subClasses" : [ "18", "19" ],
    "comment" : {
      "undefined" : "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach).  The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure."
    },
    "attributes" : [ "equivalent", "disjointUnion", "external" ],
    "id" : "116",
    "superClasses" : [ "97" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/CARO_0000003",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/caro.owl",
        "type" : "iri"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "CARO:0000003",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/caro#core",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "CARO_0000003",
      "en" : "connected anatomical structure",
      "undefined" : "connected anatomical structure"
    },
    "subClasses" : [ "266", "10", "595", "29", "267", "593", "265", "268", "49", "537", "221", "542" ],
    "intersection" : [ "19" ],
    "comment" : {
      "undefined" : "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development."
    },
    "attributes" : [ "intersection", "external" ],
    "id" : "167",
    "superClasses" : [ "19" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns/abnormalLevelOfChemicalEntityInLocation.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns",
    "instances" : 0,
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "An abnormal level of 'chemical entity' in the 'independent continuant'.",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "abnormalLevelOfChemicalEntityInLocation",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "abnormalLevelOfChemicalEntityInLocation.yaml",
      "undefined" : "abnormal 'independent continuant' 'chemical entity' level"
    },
    "subClasses" : [ "65", "218", "703", "354" ],
    "attributes" : [ "external" ],
    "id" : "61",
    "superClasses" : [ "56" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/abnormalNumberOfAnatomicalEntity.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "abnormal number of 'anatomical entity's",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "altered number of 'anatomical entity's",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Any structural anomaly that causes there to be an abnormal number 'anatomical entity'.",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "abnormalNumberOfAnatomicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "abnormalNumberOfAnatomicalEntity.yaml",
      "undefined" : "abnormal number of anatomical enitites of type 'anatomical entity'"
    },
    "subClasses" : [ "271", "215", "272", "273", "216", "274" ],
    "attributes" : [ "external" ],
    "id" : "400",
    "superClasses" : [ "270" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0001617",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "thefreedictionary.com:thefreedictionary.com",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.",
        "type" : "label"
      } ],
      "hasRelatedSynonym" : [ {
        "identifier" : "hasRelatedSynonym",
        "language" : "undefined",
        "value" : "disfigured",
        "type" : "label"
      }, {
        "identifier" : "hasRelatedSynonym",
        "language" : "undefined",
        "value" : "distorted",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0001617",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#value_slim",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0001617",
      "undefined" : "deformed"
    },
    "subClasses" : [ "785" ],
    "attributes" : [ "external" ],
    "id" : "784",
    "superClasses" : [ "203" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/apoptoticAnatomicalEntity.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "An abnormally apoptotic 'anatomical entity'.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "'anatomical entity' with apoptosis",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "apoptoticAnatomicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "apoptoticAnatomicalEntity.yaml",
      "undefined" : "abnormally apoptotic 'anatomical entity'"
    },
    "attributes" : [ "external" ],
    "id" : "600",
    "superClasses" : [ "331", "332" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/abnormalShapeOfPhysicalEntity",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Any structural anomaly in the shape of the 'entity'.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "abnormally shaped 'entity'",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "abnormalShapeOfPhysicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "abnormalShapeOfPhysicalEntity",
      "undefined" : "abnormal shape of 'entity' "
    },
    "subClasses" : [ "572" ],
    "attributes" : [ "external" ],
    "id" : "757",
    "superClasses" : [ "391" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000031",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "BFO_0000180" : [ {
        "identifier" : "BFO_0000180",
        "language" : "undefined",
        "value" : "GenericallyDependentContinuant",
        "type" : "label"
      } ],
      "isDefinedBy" : [ {
        "identifier" : "isDefinedBy",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo.owl",
        "type" : "iri"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])",
        "type" : "label"
      } ],
      "BFO_0000179" : [ {
        "identifier" : "BFO_0000179",
        "language" : "undefined",
        "value" : "gdc",
        "type" : "label"
      } ],
      "IAO_0000602" : [ {
        "identifier" : "IAO_0000602",
        "language" : "undefined",
        "value" : "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] ",
        "type" : "label"
      } ],
      "IAO_0010000" : [ {
        "identifier" : "IAO_0010000",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/bfo/axiom/074-001",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000031",
      "en" : "generically dependent continuant"
    },
    "attributes" : [ "external" ],
    "id" : "251",
    "superClasses" : [ "74" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000030",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "bfo",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "BFO:0000030",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000030",
      "undefined" : "object"
    },
    "subClasses" : [ "594", "486" ],
    "attributes" : [ "external" ],
    "id" : "487",
    "superClasses" : [ "69" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/calcifiedAnatomicalEntity.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Calcification of the 'anatomical entity'.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "calcified 'anatomical entity'",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "calcifiedAnatomicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "calcifiedAnatomicalEntity.yaml",
      "undefined" : "'anatomical entity' calcification"
    },
    "attributes" : [ "external" ],
    "id" : "804",
    "superClasses" : [ "331", "332" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/abnormallyIncreasedThicknessOfAnatomicalEntity.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "thickened 'anatomical entity'",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "An increase in the thickness of the 'anatomical entity'.",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "abnormallyIncreasedThicknessOfAnatomicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "abnormallyIncreasedThicknessOfAnatomicalEntity.yaml",
      "undefined" : "increased thickness of the 'anatomical entity'"
    },
    "attributes" : [ "external" ],
    "id" : "567",
    "superClasses" : [ "388", "396" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/abnormallyDecreasedPigmentationOfAnatomicalEntity.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "'anatomical entity' hypopigmentation",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "loss of pigment in the 'anatomical entity'",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Decreased or loss of pigmentation of 'anatomical entity'.",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "abnormallyDecreasedPigmentationOfAnatomicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "abnormallyDecreasedPigmentationOfAnatomicalEntity.yaml",
      "undefined" : "decreased pigmentation in the 'anatomical entity'"
    },
    "attributes" : [ "external" ],
    "id" : "239",
    "superClasses" : [ "235" ]
  }, {
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        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#value_slim",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002245",
      "undefined" : "increased force"
    },
    "subClasses" : [ "24" ],
    "intersection" : [ "281" ],
    "attributes" : [ "intersection", "external" ],
    "id" : "25",
    "superClasses" : [ "281", "100" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0000068",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0000068",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0000068",
      "undefined" : "qualitative"
    },
    "subClasses" : [ "14", "145" ],
    "comment" : {
      "undefined" : "TODO: define this or obsolete it and move children somewhere else."
    },
    "attributes" : [ "external" ],
    "id" : "237",
    "superClasses" : [ "402" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0002246",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:GVG",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "decreased force amplitude",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A force which is relative low.",
        "type" : "label"
      } ],
      "RO_0002604" : [ {
        "identifier" : "RO_0002604",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/PATO_0002245",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0002246",
        "type" : "label"
      } ],
      "creation_date" : [ {
        "identifier" : "creation_date",
        "language" : "undefined",
        "value" : "2010-08-04T11:13:13Z",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#value_slim",
        "type" : "iri"
      } ],
      "created_by" : [ {
        "identifier" : "created_by",
        "language" : "undefined",
        "value" : "george",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002246",
      "undefined" : "decreased force"
    },
    "subClasses" : [ "33" ],
    "intersection" : [ "281" ],
    "attributes" : [ "intersection", "external" ],
    "id" : "34",
    "superClasses" : [ "281", "118" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0002001",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:CJM",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "has decreased number of",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "has fewer physical parts of type",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "decreased number of",
        "type" : "label"
      } ],
      "RO_0002604" : [ {
        "identifier" : "RO_0002604",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/PATO_0002002",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0002001",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#relational_slim",
        "type" : "iri"
      } ],
      "hasAlternativeId" : [ {
        "identifier" : "hasAlternativeId",
        "language" : "undefined",
        "value" : "PATO:0001569",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002001",
      "undefined" : "has fewer parts of type"
    },
    "intersection" : [ "823" ],
    "comment" : {
      "undefined" : "Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type."
    },
    "attributes" : [ "intersection", "external" ],
    "id" : "510",
    "superClasses" : [ "823", "118" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0002002",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:CJM",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "having supernumerary physical parts",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "having extra physical parts",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "increased number of",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "has extra parts of",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "has increased number of",
        "type" : "label"
      } ],
      "RO_0002604" : [ {
        "identifier" : "RO_0002604",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/PATO_0002001",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0002002",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#relational_slim",
        "type" : "iri"
      } ],
      "hasAlternativeId" : [ {
        "identifier" : "hasAlternativeId",
        "language" : "undefined",
        "value" : "PATO:0001560",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002002",
      "undefined" : "has extra parts of type"
    },
    "intersection" : [ "475" ],
    "comment" : {
      "undefined" : "In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q=<this> E2=finger."
    },
    "attributes" : [ "intersection", "external" ],
    "id" : "500",
    "superClasses" : [ "475", "100" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0002000",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "OBO_REL:lacks_part",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:CJM",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "lacks all physical parts of type",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0002000",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#relational_slim",
        "type" : "iri"
      } ],
      "hasAlternativeId" : [ {
        "identifier" : "hasAlternativeId",
        "language" : "undefined",
        "value" : "PATO:0001557",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002000",
      "undefined" : "lacks all parts of type"
    },
    "comment" : {
      "undefined" : "Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2."
    },
    "attributes" : [ "external" ],
    "id" : "705",
    "superClasses" : [ "823" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/GO_0023057",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "GOC:mtg_signal",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "GOC:bf",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "GOC:mah",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.",
        "type" : "label"
      } ],
      "hasRelatedSynonym" : [ {
        "identifier" : "hasRelatedSynonym",
        "language" : "undefined",
        "value" : "negative regulation of signalling process",
        "type" : "label"
      }, {
        "identifier" : "hasRelatedSynonym",
        "language" : "undefined",
        "value" : "negative regulation of signaling process",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "biological_process",
        "type" : "label"
      } ],
      "creation_date" : [ {
        "identifier" : "creation_date",
        "language" : "undefined",
        "value" : "2010-02-16T09:30:50Z",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "GO:0023057",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "GO_0023057",
      "undefined" : "negative regulation of signaling"
    },
    "subClasses" : [ "255" ],
    "intersection" : [ "328" ],
    "attributes" : [ "intersection", "external" ],
    "id" : "80",
    "superClasses" : [ "479", "81" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/GO_0023056",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "GOC:mah",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "GOC:bf",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "GOC:mtg_signal",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "positive regulation of signalling process",
        "type" : "label"
      } ],
      "hasRelatedSynonym" : [ {
        "identifier" : "hasRelatedSynonym",
        "language" : "undefined",
        "value" : "positive regulation of signaling process",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "biological_process",
        "type" : "label"
      } ],
      "creation_date" : [ {
        "identifier" : "creation_date",
        "language" : "undefined",
        "value" : "2010-02-16T09:30:50Z",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "GO:0023056",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "GO_0023056",
      "undefined" : "positive regulation of signaling"
    },
    "subClasses" : [ "260" ],
    "intersection" : [ "328" ],
    "attributes" : [ "intersection", "external" ],
    "id" : "83",
    "superClasses" : [ "466", "81" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev/abnormalHasFewerPartsOfTypeAnatomicalEntity.yaml",
    "baseIri" : "http://purl.obolibrary.org/obo/upheno/patterns-dev",
    "instances" : 0,
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Any structural anomaly of 'anatomical entity' that causes there to be fewer parts of type 'anatomical entity'.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "fewer 'anatomical entity's in 'anatomical entity'",
        "type" : "label"
      } ],
      "title" : [ {
        "identifier" : "title",
        "language" : "undefined",
        "value" : "abnormalHasFewerPartsOfTypeAnatomicalEntity",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "abnormalHasFewerPartsOfTypeAnatomicalEntity.yaml",
      "undefined" : "'anatomical entity' that has fewer parts of type 'anatomical entity'"
    },
    "attributes" : [ "external" ],
    "id" : "839",
    "superClasses" : [ "742" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/NCBITaxon_10239",
    "equivalent" : [ "21" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ncbitaxon.owl",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "NCBITaxon_10239",
      "undefined" : "Viruses"
    },
    "attributes" : [ "equivalent", "external" ],
    "id" : "37",
    "superClasses" : [ "11" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0002009",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:MAH",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity.",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0002009",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#cell_quality",
        "type" : "iri"
      }, {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#attribute_slim",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002009",
      "undefined" : "branchiness"
    },
    "subClasses" : [ "206" ],
    "attributes" : [ "external" ],
    "id" : "207",
    "superClasses" : [ "840" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0002249",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:GVG",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "depigmented",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A degree of pigmentation quality inhering in a bearer by virtue of the bearer's lacking substances produced by living organisms that have a color resulting from selective color absorption.",
        "type" : "label"
      } ],
      "RO_0002604" : [ {
        "identifier" : "RO_0002604",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/PATO_0002248",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0002249",
        "type" : "label"
      } ],
      "creation_date" : [ {
        "identifier" : "creation_date",
        "language" : "undefined",
        "value" : "2010-08-09T04:17:04Z",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#mpath_slim",
        "type" : "iri"
      }, {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/pato#value_slim",
        "type" : "iri"
      } ],
      "created_by" : [ {
        "identifier" : "created_by",
        "language" : "undefined",
        "value" : "george",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "PATO_0002249",
      "undefined" : "unpigmented"
    },
    "attributes" : [ "external" ],
    "id" : "151",
    "superClasses" : [ "152" ]
  }, {
    "iri" : "http://purl.obolibrary.org/obo/PATO_0000069",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "instances" : 0,
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:GVG",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "PATO:0000069",
        "type" : "label"
      } ],
      "inSubset" : [ {
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      } ],
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    "baseIri" : "http://purl.obolibrary.org/obo",
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      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
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        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
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        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
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        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
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        "language" : "en",
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        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
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        "type" : "label"
      } ],
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        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
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      }, {
        "identifier" : "IAO_0000116",
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        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
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      } ]
    },
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      } ],
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    },
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    "baseIri" : "http://purl.obolibrary.org/obo/pato",
    "range" : "705",
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:CJM",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "reciprocal_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "reciprocal_of",
      "undefined" : "reciprocal_of"
    },
    "domain" : "13",
    "comment" : {
      "undefined" : "There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality."
    },
    "attributes" : [ "object", "someValues", "external" ],
    "id" : "704"
  }, {
    "range" : "632",
    "domain" : "707",
    "attributes" : [ "anonymous", "object" ],
    "id" : "706"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002418",
    "inverse" : "620",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "hasRelatedSynonym" : [ {
        "identifier" : "hasRelatedSynonym",
        "language" : "undefined",
        "value" : "affects",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "undefined",
        "value" : "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2",
        "type" : "label"
      } ],
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "undefined",
        "value" : "influences (processual)",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002418",
      "undefined" : "causally upstream of or within"
    },
    "superproperty" : [ "625" ],
    "domain" : "27",
    "subproperty" : [ "4", "709", "710" ],
    "attributes" : [ "transitive", "object", "external" ],
    "id" : "708"
  }, {
    "range" : "123",
    "domain" : "189",
    "attributes" : [ "anonymous", "object" ],
    "id" : "711"
  }, {
    "range" : "376",
    "domain" : "138",
    "attributes" : [ "anonymous", "object" ],
    "id" : "712"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "667",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "714",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "713"
  }, {
    "range" : "118",
    "domain" : "232",
    "attributes" : [ "anonymous", "object" ],
    "id" : "715"
  }, {
    "range" : "307",
    "domain" : "634",
    "attributes" : [ "anonymous", "object" ],
    "id" : "716"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000051",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "15",
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000051",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:CJM",
        "type" : "label"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "has part",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this year has part this day (occurrent parthood)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my body has part my brain (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a whole and its part",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.",
        "type" : "label"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "chebi_ontology",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.",
        "type" : "label"
      } ],
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "has_part",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "has_part",
        "type" : "label"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "has_part",
        "type" : "label"
      } ],
      "is_cyclic" : [ {
        "identifier" : "is_cyclic",
        "language" : "undefined",
        "value" : "false",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000051",
      "en" : "has part",
      "undefined" : "has part"
    },
    "superproperty" : [ "608" ],
    "domain" : "189",
    "subproperty" : [ "430" ],
    "comment" : {
      "undefined" : "We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'."
    },
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "717"
  }, {
    "range" : "118",
    "domain" : "34",
    "attributes" : [ "anonymous", "object" ],
    "id" : "718"
  }, {
    "range" : "406",
    "domain" : "470",
    "attributes" : [ "anonymous", "object" ],
    "id" : "719"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "10",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "97",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "720"
  }, {
    "range" : "118",
    "domain" : "346",
    "attributes" : [ "anonymous", "object" ],
    "id" : "721"
  }, {
    "range" : "406",
    "domain" : "723",
    "attributes" : [ "anonymous", "object" ],
    "id" : "722"
  }, {
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    "annotations" : {
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      } ],
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      } ]
    },
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      } ],
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        "identifier" : "IAO_0000118",
        "language" : "en",
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        "type" : "label"
      } ],
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        "identifier" : "shorthand",
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      } ],
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        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
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        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
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        "type" : "iri"
      } ],
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        "language" : "undefined",
        "value" : "uberon",
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      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
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        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
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      } ],
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        "language" : "en",
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      }, {
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        "type" : "label"
      }, {
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        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
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        "identifier" : "id",
        "language" : "undefined",
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        "type" : "label"
      } ]
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      "undefined" : "part_of"
    },
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    "annotations" : {
      "IAO_0000232" : [ {
        "identifier" : "IAO_0000232",
        "language" : "undefined",
        "value" : "Regulation precludes parthood; the regulatory process may not be within the regulated process.",
        "type" : "label"
      } ],
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        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.",
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      } ],
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        "language" : "undefined",
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        "type" : "label"
      } ],
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        "value" : "false",
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      }, {
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      "undefined" : "regulates"
    },
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    "subproperty" : [ "5", "6", "7", "8" ],
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    "range" : "156",
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        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
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        "type" : "label"
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        "value" : "this day is part of this year (occurrent parthood)",
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        "language" : "en",
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        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
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        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
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        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "141",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "753"
  }, {
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    "inverse" : "3",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "570",
    "annotations" : {
      "IAO_0000232" : [ {
        "identifier" : "IAO_0000232",
        "language" : "undefined",
        "value" : "Regulation precludes parthood; the regulatory process may not be within the regulated process.",
        "type" : "label"
      } ],
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        "value" : "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.",
        "type" : "label"
      } ],
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      }, {
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        "type" : "label"
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      } ],
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      }, {
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      }, {
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      } ],
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      } ],
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        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
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      }, {
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        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
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    },
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    },
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      } ],
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        "type" : "label"
      } ],
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        "language" : "undefined",
        "value" : "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit",
        "type" : "label"
      } ],
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      } ],
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      } ],
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    },
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      } ],
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      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "regulates",
        "type" : "label"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "regulates",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002211",
      "en" : "regulates",
      "undefined" : "regulates"
    },
    "superproperty" : [ "4" ],
    "domain" : "370",
    "subproperty" : [ "5", "6", "7", "8" ],
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "795"
  }, {
    "range" : "388",
    "domain" : "797",
    "attributes" : [ "anonymous", "object" ],
    "id" : "796"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002212",
    "inverse" : "125",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "693",
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "RO:0002212",
        "type" : "label"
      } ],
      "RO_0004050" : [ {
        "identifier" : "RO_0004050",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0002211",
        "type" : "iri"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "en",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      } ],
      "IAO_0000589" : [ {
        "identifier" : "IAO_0000589",
        "language" : "undefined",
        "value" : "negatively regulates (process to process)",
        "type" : "label"
      } ],
      "IAO_0000119" : [ {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/docs/causal-relations",
        "type" : "iri"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "negatively_regulates",
        "type" : "label"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "negatively_regulates",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002212",
      "en" : "negatively regulates",
      "undefined" : "negatively regulates"
    },
    "superproperty" : [ "126", "111" ],
    "domain" : "373",
    "subproperty" : [ "127" ],
    "attributes" : [ "object", "someValues", "external" ],
    "id" : "798"
  }, {
    "range" : "388",
    "domain" : "800",
    "attributes" : [ "anonymous", "object" ],
    "id" : "799"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002436",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "undefined",
        "value" : "binds",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000118",
        "language" : "undefined",
        "value" : "molecularly binds with",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ECO_0000353",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/MI_0915",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002436",
      "undefined" : "molecularly interacts with"
    },
    "superproperty" : [ "801" ],
    "domain" : "27",
    "subproperty" : [ "766", "774" ],
    "attributes" : [ "object", "symmetric", "external" ],
    "id" : "769"
  }, {
    "range" : "388",
    "domain" : "803",
    "attributes" : [ "anonymous", "object" ],
    "id" : "802"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to",
    "baseIri" : "http://purl.obolibrary.org/obo/pato",
    "range" : "402",
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "PATOC:CJM",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "increased_in_magnitude_relative_to",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "increased_in_magnitude_relative_to",
      "undefined" : "increased_in_magnitude_relative_to"
    },
    "superproperty" : [ "401" ],
    "domain" : "402",
    "comment" : {
      "undefined" : "This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'."
    },
    "attributes" : [ "transitive", "object", "external" ],
    "id" : "404"
  }, {
    "range" : "388",
    "domain" : "539",
    "attributes" : [ "anonymous", "object" ],
    "id" : "805"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002434",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "69",
    "annotations" : {
      "IAO_0000232" : [ {
        "identifier" : "IAO_0000232",
        "language" : "undefined",
        "value" : "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "in pairwise interaction with",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A relationship that holds between two entities in which the processes executed by the two entities are causally connected.",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "undefined",
        "value" : "Considering relabeling as 'pairwise interacts with'",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "undefined",
        "value" : "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.",
        "type" : "label"
      } ],
      "page" : [ {
        "identifier" : "page",
        "language" : "undefined",
        "value" : "https://github.com/oborel/obo-relations/wiki/InteractionRelations",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/subsets#ro-eco",
        "type" : "iri"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/MI_0914",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002434",
      "undefined" : "interacts with"
    },
    "domain" : "69",
    "subproperty" : [ "769" ],
    "attributes" : [ "object", "symmetric", "external" ],
    "id" : "801"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002211",
    "inverse" : "3",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "108",
    "annotations" : {
      "IAO_0000232" : [ {
        "identifier" : "IAO_0000232",
        "language" : "undefined",
        "value" : "Regulation precludes parthood; the regulatory process may not be within the regulated process.",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "RO:0002211",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.",
        "type" : "label"
      } ],
      "IAO_0000114" : [ {
        "identifier" : "IAO_0000114",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/IAO_0000125",
        "type" : "iri"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "Tanya Berardini",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "David Hill",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "undefined",
        "value" : "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit",
        "type" : "label"
      } ],
      "IAO_0000589" : [ {
        "identifier" : "IAO_0000589",
        "language" : "undefined",
        "value" : "regulates (processual)",
        "type" : "label"
      } ],
      "IAO_0000600" : [ {
        "identifier" : "IAO_0000600",
        "language" : "undefined",
        "value" : "false",
        "type" : "label"
      } ],
      "IAO_0000119" : [ {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/docs/causal-relations",
        "type" : "iri"
      }, {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "GO",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "regulates",
        "type" : "label"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "regulates",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002211",
      "en" : "regulates",
      "undefined" : "regulates"
    },
    "superproperty" : [ "4" ],
    "domain" : "375",
    "subproperty" : [ "5", "6", "7", "8" ],
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "806"
  }, {
    "range" : "433",
    "domain" : "808",
    "attributes" : [ "anonymous", "object" ],
    "id" : "807"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "74",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "74",
    "attributes" : [ "transitive", "object", "external", "allValues" ],
    "id" : "809"
  }, {
    "range" : "348",
    "domain" : "347",
    "attributes" : [ "anonymous", "object" ],
    "id" : "810"
  }, {
    "range" : "348",
    "domain" : "812",
    "attributes" : [ "anonymous", "object" ],
    "id" : "811"
  }, {
    "range" : "363",
    "domain" : "814",
    "attributes" : [ "anonymous", "object" ],
    "id" : "813"
  }, {
    "range" : "149",
    "domain" : "660",
    "attributes" : [ "anonymous", "object" ],
    "id" : "815"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "171",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
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      } ],
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        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
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        "value" : "uberon",
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      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
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      }, {
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      }, {
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      }, {
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      } ],
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    "annotations" : {
      "IAO_0000232" : [ {
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      } ],
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      } ],
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    },
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        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/subsets#ro-eco",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002086",
      "en" : "ends after"
    },
    "superproperty" : [ "198" ],
    "domain" : "27",
    "subproperty" : [ "548" ],
    "comment" : {
      "en" : "X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)"
    },
    "attributes" : [ "transitive", "object", "external" ],
    "id" : "200"
  }, {
    "range" : "411",
    "domain" : "493",
    "attributes" : [ "anonymous", "object" ],
    "id" : "862"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002087",
    "inverse" : "554",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "SIO:000251",
        "type" : "label"
      }, {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "RO:0002087",
        "type" : "label"
      } ],
      "hasExactSynonym" : [ {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "is immediately preceded by",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "directly preceded by",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "is directly preceded by",
        "type" : "label"
      }, {
        "identifier" : "hasExactSynonym",
        "language" : "undefined",
        "value" : "starts_at_end_of",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "David Osumi-Sutherland",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      } ],
      "UBPROP_0000001" : [ {
        "identifier" : "UBPROP_0000001",
        "language" : "undefined",
        "value" : "A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].",
        "type" : "label"
      } ],
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "undefined",
        "value" : "starts_at_end_of",
        "type" : "label"
      } ],
      "source" : [ {
        "identifier" : "source",
        "language" : "undefined",
        "value" : "SIO:000251",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "immediately_preceded_by",
        "type" : "label"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "immediately_preceded_by",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/SIO_000251",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002087",
      "en" : "immediately preceded by",
      "undefined" : "immediately_preceded_by"
    },
    "superproperty" : [ "548" ],
    "domain" : "27",
    "subproperty" : [ "616" ],
    "comment" : {
      "en" : "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)"
    },
    "attributes" : [ "object", "external" ],
    "id" : "550"
  }, {
    "range" : "100",
    "domain" : "340",
    "attributes" : [ "anonymous", "object" ],
    "id" : "863"
  }, {
    "range" : "100",
    "domain" : "25",
    "attributes" : [ "anonymous", "object" ],
    "id" : "864"
  }, {
    "range" : "100",
    "domain" : "499",
    "attributes" : [ "anonymous", "object" ],
    "id" : "865"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0004047",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "creation_date" : [ {
        "identifier" : "creation_date",
        "language" : "undefined",
        "value" : "2018-03-13T23:55:19Z",
        "type" : "label"
      } ],
      "RO_0004049" : [ {
        "identifier" : "RO_0004049",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0002418",
        "type" : "iri"
      } ],
      "created_by" : [ {
        "identifier" : "created_by",
        "language" : "undefined",
        "value" : "cjm",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0004047",
      "undefined" : "causally upstream of or within, positive effect"
    },
    "superproperty" : [ "708" ],
    "domain" : "27",
    "subproperty" : [ "110" ],
    "attributes" : [ "object", "external" ],
    "id" : "709"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0004046",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "RO_0004050" : [ {
        "identifier" : "RO_0004050",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0002418",
        "type" : "iri"
      } ],
      "creation_date" : [ {
        "identifier" : "creation_date",
        "language" : "undefined",
        "value" : "2018-03-13T23:55:05Z",
        "type" : "label"
      } ],
      "created_by" : [ {
        "identifier" : "created_by",
        "language" : "undefined",
        "value" : "cjm",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0004046",
      "undefined" : "causally upstream of or within, negative effect"
    },
    "superproperty" : [ "708" ],
    "domain" : "27",
    "subproperty" : [ "126" ],
    "attributes" : [ "object", "external" ],
    "id" : "710"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "139",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "667",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "868"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "707",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "667",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "869"
  }, {
    "range" : "49",
    "domain" : "265",
    "attributes" : [ "anonymous", "object" ],
    "id" : "870"
  }, {
    "range" : "542",
    "domain" : "49",
    "attributes" : [ "anonymous", "object" ],
    "id" : "871"
  }, {
    "range" : "49",
    "domain" : "593",
    "attributes" : [ "anonymous", "object" ],
    "id" : "872"
  }, {
    "range" : "221",
    "domain" : "49",
    "attributes" : [ "anonymous", "object" ],
    "id" : "873"
  }, {
    "range" : "49",
    "domain" : "537",
    "attributes" : [ "anonymous", "object" ],
    "id" : "874"
  }, {
    "range" : "542",
    "domain" : "593",
    "attributes" : [ "anonymous", "object" ],
    "id" : "875"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "268",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "595",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "876"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/BFO_0000050",
    "inverse" : "607",
    "equivalent" : [ "609" ],
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "619",
    "annotations" : {
      "IAO_0000118" : [ {
        "identifier" : "IAO_0000118",
        "language" : "en",
        "value" : "part_of",
        "type" : "label"
      } ],
      "RO_0040042" : [ {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000031",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000020",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000019",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000002",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000003",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000017",
        "type" : "iri"
      }, {
        "identifier" : "RO_0040042",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO_0000004",
        "type" : "iri"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ],
      "seeAlso" : [ {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://www.obofoundry.org/ro/#OBO_REL:part_of",
        "type" : "label"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Submissions:PartOf",
        "type" : "iri"
      }, {
        "identifier" : "seeAlso",
        "language" : "undefined",
        "value" : "http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections",
        "type" : "iri"
      } ],
      "IAO_0000111" : [ {
        "identifier" : "IAO_0000111",
        "language" : "en",
        "value" : "is part of",
        "type" : "label"
      } ],
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "BFO:0000050",
        "type" : "label"
      } ],
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "my brain is part of my body (continuant parthood, two material entities)",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000112",
        "language" : "en",
        "value" : "this day is part of this year (occurrent parthood)",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "en",
        "value" : "a core relation that holds between a part and its whole",
        "type" : "label"
      } ],
      "IAO_0000412" : [ {
        "identifier" : "IAO_0000412",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/BFO",
        "type" : "iri"
      } ],
      "RO_0001900" : [ {
        "identifier" : "RO_0001900",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0001901",
        "type" : "iri"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "protein",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "external",
        "type" : "label"
      }, {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "quality",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime",
        "type" : "label"
      }, {
        "identifier" : "IAO_0000116",
        "language" : "en",
        "value" : "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.",
        "type" : "label"
      } ],
      "id" : [ {
        "identifier" : "id",
        "language" : "undefined",
        "value" : "part_of",
        "type" : "label"
      } ]
    },
    "label" : {
      "IRI-based" : "BFO_0000050",
      "en" : "part of",
      "undefined" : "part_of"
    },
    "superproperty" : [ "608" ],
    "domain" : "667",
    "attributes" : [ "transitive", "object", "someValues", "external" ],
    "id" : "877"
  }, {
    "range" : "370",
    "domain" : "375",
    "attributes" : [ "anonymous", "object" ],
    "id" : "878"
  }, {
    "range" : "311",
    "domain" : "644",
    "attributes" : [ "anonymous", "object" ],
    "id" : "879"
  }, {
    "range" : "855",
    "domain" : "881",
    "attributes" : [ "anonymous", "object" ],
    "id" : "880"
  }, {
    "range" : "432",
    "domain" : "502",
    "attributes" : [ "anonymous", "object" ],
    "id" : "882"
  }, {
    "range" : "375",
    "domain" : "94",
    "attributes" : [ "anonymous", "object" ],
    "id" : "883"
  }, {
    "range" : "432",
    "domain" : "817",
    "attributes" : [ "anonymous", "object" ],
    "id" : "884"
  }, {
    "range" : "375",
    "domain" : "326",
    "attributes" : [ "anonymous", "object" ],
    "id" : "885"
  }, {
    "range" : "52",
    "domain" : "285",
    "attributes" : [ "anonymous", "object" ],
    "id" : "886"
  }, {
    "range" : "375",
    "domain" : "107",
    "attributes" : [ "anonymous", "object" ],
    "id" : "887"
  }, {
    "range" : "52",
    "domain" : "51",
    "attributes" : [ "anonymous", "object" ],
    "id" : "888"
  }, {
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    "domain" : "94",
    "attributes" : [ "anonymous", "object" ],
    "id" : "889"
  }, {
    "range" : "374",
    "domain" : "107",
    "attributes" : [ "anonymous", "object" ],
    "id" : "890"
  }, {
    "iri" : "http://www.w3.org/2002/07/owl#topObjectProperty",
    "baseIri" : "http://www.w3.org/2002/07/owl",
    "range" : "27",
    "label" : {
      "IRI-based" : "topObjectProperty"
    },
    "domain" : "27",
    "subproperty" : [ "608" ],
    "attributes" : [ "object", "external" ],
    "id" : "891"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002597",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.",
        "type" : "label"
      } ],
      "IAO_0000119" : [ {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/docs/causal-relations",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002597",
      "undefined" : "capable of negatively regulating"
    },
    "superproperty" : [ "893" ],
    "domain" : "27",
    "attributes" : [ "object", "external" ],
    "id" : "892"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002596",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "IAO_0000112" : [ {
        "identifier" : "IAO_0000112",
        "language" : "undefined",
        "value" : "pyrethroid -> growth",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Holds between c and p if and only if c is capable of some activity a, and a regulates p.",
        "type" : "label"
      } ],
      "IAO_0000119" : [ {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/docs/causal-relations",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002596",
      "undefined" : "capable of regulating"
    },
    "superproperty" : [ "180" ],
    "domain" : "27",
    "subproperty" : [ "894", "892" ],
    "attributes" : [ "object", "external" ],
    "id" : "893"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002595",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "68",
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
        "identifier" : "IAO_0000117",
        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "IAO_0000116" : [ {
        "identifier" : "IAO_0000116",
        "language" : "undefined",
        "value" : "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.",
        "type" : "label"
      } ],
      "IAO_0000119" : [ {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/docs/causal-relations",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002595",
      "undefined" : "causal relation between material entity and a process"
    },
    "superproperty" : [ "623" ],
    "domain" : "69",
    "subproperty" : [ "180", "895" ],
    "attributes" : [ "object", "external" ],
    "id" : "626"
  }, {
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    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "hasDbXref" : [ {
        "identifier" : "hasDbXref",
        "language" : "undefined",
        "value" : "RO:0002352",
        "type" : "label"
      } ],
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "inverse of has input",
        "type" : "label"
      } ],
      "hasOBONamespace" : [ {
        "identifier" : "hasOBONamespace",
        "language" : "undefined",
        "value" : "uberon",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
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        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "id" : [ {
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        "language" : "undefined",
        "value" : "input_of",
        "type" : "label"
      } ],
      "shorthand" : [ {
        "identifier" : "shorthand",
        "language" : "undefined",
        "value" : "input_of",
        "type" : "label"
      } ],
      "inSubset" : [ {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/subsets#ro-eco",
        "type" : "iri"
      }, {
        "identifier" : "inSubset",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0002259",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002352",
      "en" : "input of",
      "undefined" : "input of"
    },
    "superproperty" : [ "172", "73" ],
    "domain" : "27",
    "attributes" : [ "object", "external" ],
    "id" : "70"
  }, {
    "range" : "757",
    "domain" : "572",
    "attributes" : [ "anonymous", "object" ],
    "id" : "896"
  }, {
    "range" : "487",
    "domain" : "594",
    "attributes" : [ "anonymous", "object" ],
    "id" : "897"
  }, {
    "range" : "135",
    "domain" : "152",
    "attributes" : [ "anonymous", "object" ],
    "id" : "898"
  }, {
    "range" : "487",
    "domain" : "486",
    "attributes" : [ "anonymous", "object" ],
    "id" : "899"
  }, {
    "range" : "370",
    "domain" : "373",
    "attributes" : [ "anonymous", "object" ],
    "id" : "900"
  }, {
    "range" : "311",
    "domain" : "629",
    "attributes" : [ "anonymous", "object" ],
    "id" : "901"
  }, {
    "range" : "370",
    "domain" : "374",
    "attributes" : [ "anonymous", "object" ],
    "id" : "902"
  }, {
    "range" : "311",
    "domain" : "307",
    "attributes" : [ "anonymous", "object" ],
    "id" : "903"
  }, {
    "range" : "341",
    "domain" : "364",
    "attributes" : [ "anonymous", "object" ],
    "id" : "904"
  }, {
    "range" : "400",
    "domain" : "274",
    "attributes" : [ "anonymous", "object" ],
    "id" : "905"
  }, {
    "range" : "135",
    "domain" : "134",
    "attributes" : [ "anonymous", "object" ],
    "id" : "906"
  }, {
    "range" : "784",
    "domain" : "785",
    "attributes" : [ "anonymous", "object" ],
    "id" : "907"
  }, {
    "range" : "135",
    "domain" : "365",
    "attributes" : [ "anonymous", "object" ],
    "id" : "908"
  }, {
    "range" : "911",
    "domain" : "910",
    "attributes" : [ "anonymous", "object" ],
    "id" : "909"
  }, {
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    "domain" : "366",
    "attributes" : [ "anonymous", "object" ],
    "id" : "912"
  }, {
    "range" : "881",
    "domain" : "501",
    "attributes" : [ "anonymous", "object" ],
    "id" : "913"
  }, {
    "range" : "135",
    "domain" : "367",
    "attributes" : [ "anonymous", "object" ],
    "id" : "914"
  }, {
    "range" : "881",
    "domain" : "511",
    "attributes" : [ "anonymous", "object" ],
    "id" : "915"
  }, {
    "iri" : "http://purl.obolibrary.org/obo/RO_0002578",
    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
      "IAO_0000115" : [ {
        "identifier" : "IAO_0000115",
        "language" : "undefined",
        "value" : "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.",
        "type" : "label"
      } ],
      "IAO_0000117" : [ {
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        "language" : "undefined",
        "value" : "Chris Mungall",
        "type" : "label"
      } ],
      "IAO_0000589" : [ {
        "identifier" : "IAO_0000589",
        "language" : "undefined",
        "value" : "directly regulates (processual)",
        "type" : "label"
      } ],
      "IAO_0000119" : [ {
        "identifier" : "IAO_0000119",
        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/ro/docs/causal-relations",
        "type" : "iri"
      } ],
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        "language" : "undefined",
        "value" : "http://purl.obolibrary.org/obo/RO_0002211",
        "type" : "iri"
      } ]
    },
    "label" : {
      "IRI-based" : "RO_0002578",
      "undefined" : "directly regulates"
    },
    "superproperty" : [ "617", "111" ],
    "domain" : "27",
    "subproperty" : [ "127", "112" ],
    "attributes" : [ "object", "external" ],
    "id" : "5"
  }, {
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    "baseIri" : "http://purl.obolibrary.org/obo",
    "range" : "27",
    "annotations" : {
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