text:
Through forests of emerald-green bliss,
She pranced,
Embracing the colors of endless play—
The rainbows of summer.
She was a child of the earth.
Her tiny voice sang,
And she danced!
No danger lurked in her twinkling eyes.
Everything in her fearless laughter
Was colored with mirth.
She built castles on the shore
By a peaceful and provident sea
That was never foreboding.
She skipped beneath the golden clouds
Like the world belonged to her,
As if there were no cares
And all who loved her
Would keep her safe.
"Do not lose her," I said.
"Do not lose that child.
She needs you so desperately."
And then she had this grave fear of the sea,
This somber foreboding.
It seemed so vast and so deep
From the shore,
A leviathan-green, hellish monstrosity
Full of strange creatures that devoured things.
It was all that lay between her
And some faraway place
On the other side of the globe.
Somehow, it was not so frightening now.
Neither was the past,
The present,
Or all the future obscurities—
Not even those people she once had cherished.
The peace of the waters subdued her now,
As she listened to the thrash of the waves.
She was just playing with a stick in the sand.
There was a noted ambiguity
Whenever she spoke of this place.
Certain moments when she embraced the glorious light
And gazed intently into the darkness.
There were moments, too,
When she felt it creep and crawl around her,
When she ached and trembled,
Longing to free herself from its grip.
While seething within,
She wore the mask of kindness,
Harmless and alluring,
With resentment like hemlock,
Beautiful yet wilting,
Glowing yet tarnished,
Standing tall,
And unyielding…
Toxic to all
In her flowering beauty.
The sun was setting,
Salmon clouds under a sky of dodger blue,
Flocks of geese
On a sprawling lawn.
A waxing gibbous moon
Like she needed a guide,
A divine light.
"Come forth," it said.
"Come home."
And some of the fear waned
As she went forth,
But nothing really changed.
She stood alone on the edge,
In darkness,
A faint silhouette
Gazing at the night sky.
Rain fell,
A sprinkler to the trees
Thrashing in the wind.
She would flee,
Abandoning places,
Suddenly unrecognizable faces.
The glowing sun of Helios
Was a beacon
For eternal bliss,
Yet deceiving.
The caves beckoned.
Every corner,
Every crevice,
Held its own mystery,
Its truth.
Still the perilous journey
Was madness—
Pretty colors and then
It seemed to have no end.
She heard a child crying,
A child from long ago,
A prisoner of her soul.
Stone walls around her,
Hissing sounds,
Deep, treacherous waters—
Her mind was a fractured maze.
No one could see.
No one could hear.
No safe place to run,
She had to find the way
Every stone that healed
Brought her closer to
The truth,
The light.
The climb was steep,
But she held on,
Clawing her way
In blindness,
Raindrops glistened on the rocks.
Flower petals littered
The wet grass.
She saw vibrant orchids
In the fading light of the moon,
And, alas,
Tranquil waters glistened
Aqua blue.
Like the ancient alchemical goddess,
She was crowned—
A newborn only beginning
To awaken,
Beginning to see,
Her soul bursting
With bliss.
The beauty within
Became the beauty
Eyes could see,
Not perfection—
Courage, perhaps…
And love.
She was free.
No jewel could sparkle with
More radiance,
And the years could not tarnish its shine.
From Remnants of Severed Chains © Copyright October 17, 2015 by Kyrian Lyndon at kyrianlyndon.com. All rights reserved. No reproduction permitted without permission.


text:
The newsiest bit from yesterday's interview with Telemundo. Rubio's said since the beginning that the path to citizenship (which is different from initial probationary legal status) can't happen until the border's been tightened, so if O insists upon this then Rubio's destined to walk away.
But would Obama insist upon it, to the point of veto? I'm skeptical.
While he expressed optimism that a final bill will contain a path to citizenship for those currently in the country illegally, Obama would not offer specifics on how long the process of obtaining citizenship should take.
And he declined to outline how the security of the nation's border should be assessed, saying only that there should be no border security "trigger" that must be met before undocumented persons are eligible to begin the process of seeking legal status.
"We don't want to make this earned pathway to citizenship a situation in which it's put off further and further into the future," he said. "There needs to be a certain path for how people can get legal in this country, even as we also work on these strong border security issues."
He said something similar, and similarly ambiguous, in his big immigration speech at the end of January. ("But for comprehensive immigration reform to work, it must be clear from the outset that there is a pathway to citizenship.") But if he's trying to drive a hard bargain here, why would he refuse to specify in the Telemundo interview how long the path to citizenship should take? Why not say "six years" or something ridiculous like that? My theory all along on O's immigration maneuvering has been that he's trying to create political cover for the GOP by issuing demands that he knows won't be met so that Republicans can then claim "victory" over Obama later as a way to sell the bill to grassroots conservatives. Dan Pfeiffer, one of O's top advisors, freely admitted last month that he's happy to "serve as a punching bag every once in a while" so long as Rubio and the rest of the Gang of Eight are making progress. Unless and until he says plainly that he'll veto a bill if it insists on a border-security "trigger" I'm treating this as kabuki, a proposal manufactured for the purpose of conceding it later in exchange for the GOP conceding on early probationary legal status for illegals, which is what Democrats really crave. Just to add to the kabuki vibe, remember that neither side within the Gang of Eight has been bickering publicly lately about the "trigger." The bickering has to do almost exclusively with guest workers. Presumably they've already reached a deal on this issue, and since Rubio's still part of the group, I assume it broke his way. And O knows it.
Another thing. If, as many righties (including Ted Cruz) believe, Obama's intent on sabotaging the Gang of Eight, how to explain this from his interview with Univision?
"I'm actually optimistic that when they get back they will introduce a bill," Obama said during an interview with Univision. "My sense is that they have come close and my expectation is that we'll actually see a bill on the floor of the Senate next month."
The president has repeatedly said that he would propose his own immigration bill should negotiations in Congress grind to a halt. But Obama refused to say that he would take such action even if the lawmakers fail to introduce a bill in April.
Why would he do that? This is his big chance to disrupt negotiations by putting external pressure on the Gang to come up with something before he bigfoots the whole process. Issue an ultimatum: "If there's no bill by Date X then I'm taking over." Republicans would instantly walk away, and then he could go about merrily demagoging them for the next 18 months. The fact that he's not doing that suggests that he wants the bill to pass and is willing to keep a low profile to do it. Which is no small concession from this guy.
But let me play devil's advocate. What if the White House wants a bill to pass but doesn't want Rubio to be part of it? Is there a way for them to drive him away by digging in against the border security "trigger" while still gaining a majority in the Senate and House for final passage? That is to say, can they find five to 10 Republicans in the Senate and 30-40 in the House (plus Boehner, of course) who are so eager to build goodwill with Latinos that they'd rubber-stamp a bill that didn't make border improvements a prerequisite for citizenship for illegals? I'm skeptical, but I also don't underestimate the GOP's panic about demographics. There are surely lots of Democrats in the leadership who are eager to see an "earned amnesty" enacted but are also very leery of seeing Rubio's name attached to it, just in case he turns out to be more effective in attracting Latino voters in 2016 than most people expect. If they can force him out of this process so that he can't claim credit for it later while still getting something passed, that's optimal for them. But if that's the plan, and even assuming that there really are 30-40 squishy GOP votes in the House, how would Boehner's speakership survive if he violated the Hastert Rule to pass amnesty? He has no choice but to do this with a majority of House Republicans, I think, and it's very hard to see how they'd rubber-stamp an even weaker bill than the Gang of Eight's — without the political cover provided by Marco Rubio's endorsement, no less — knowing that it would likely mean primary challenges for many of them next year. If Obama really does want to get this done, I think he and the Dems will have to live with Rubio's demands.

subset: commoncrawl


text: Had this awesome submission in my tumblr inbox today- Angie Cooper from Richmond, VA. 1967 Triumph T120 chopper to be brought back to life from totheriver.tumblr.com. I just picked up this barn find last week and plan on getting her running this spring. Currently I ride a 2009 Kawasaki KLX 250SF as my daily driver and a 1974 BWM R90 for longer trips.


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text:
Kathy writes that many users are stuck using P mode, or the automatic mode of their favourite tools simply because they don't know how, or don't know why they'd like to use those extra features.
I link to this usability article here because she used camera terminology to describe how a user approaches a complex application. Even if you're not interested in the usability of stuff, and web apps in particular, then reading this article may inspire you to learn about why you haven't used the A, S, or M modes on your fancy, expensive camera.
If you're still interested, then read Understanding Exposure: How to Shoot Great Photographs with a Film or Digital Camera by Bryan Peterson. It's my favourite book on photography and it will change the way you use your camera!


text:
Professor Roger Barker
University position
Department of Clinical Neurosciences
Cambridge Centre for Brain Repair
Home page
Research Themes
Clinical and Veterinary Neuroscience
I work on:
Clinical aspects of Parkinson's and Huntington's disease including the study of disease heterogeneity using cognitive testing, functional imaging and genetic biomarkers.
Examining the value of different biomarkers to assess disease onset and progression.
Evaluating and developing novel therapies for these conditions including cell transplants.
Studying the effects of the neurodegenerative brain on intrinsic adult neurogenesis.
Research Focus
Behavioural analysis
Cell culture
Confocal microscopy
Cross-sectional and cohort studies
Fluorescence microscopy
Magnetic resonance imaging (MRI)
Neuropsychological testing
Positron Emission Tomography (PET)
Associated News Items
Key publications
Clelland CD, Choi M, Romberg C, Clemenson GD Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ (2009), "A functional role for adult hippocampal neurogenesis in spatial pattern separation." Science 325(5937):210-3 Details
O'Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA (2009), "Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF." Proc Natl Acad Sci U S A 106(21):8754-9 Details
Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJ, Brown J, Ban M, Spillantini MG, Compston A, Burn DJ, Chinnery PF, Barker RA, Sawcer SJ (2007), "Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease." Ann Neurol 62(2):145-53 Details
Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A (2014), "The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro." Development 141(11):2216-24 Details
Barker RA (2014), "Editorial." Neuropathol Appl Neurobiol 40(1):1-2
Barker RA, Mason SL (2014), "Neurodegenerative disease: Mapping the natural history of Huntington disease." Nat Rev Neurol 10(1):12-3 Details
Breen DP, Vuono R, Nawarathna U, Fisher K, Shneerson JM, Reddy AB, Barker RA (2014), "Sleep and circadian rhythm regulation in early Parkinson disease." JAMA Neurol 71(5):589-95 Details
Buttery PC, Barker RA (2014), "Treating Parkinson's disease in the 21st century: Can stem cell transplantation compete?" J Comp Neurol 522(12):2802-16 Details
Choi ML, Begeti F, Oh JH, Lee SY, O'Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA (2014), "Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease." Neurobiol Dis 66:19-27 Details
Cicchetti F, Lacroix S, Cisbani G, Valli�res N, Saint-Pierre M, St-Amour I, Tolouei R, Skepper JN, Hauser RA, Mantovani D, Barker RA, Freeman TB (2014), "Mutant huntingtin is present in neuronal grafts in huntington disease patients." Ann Neurol Details
Collins LM, Lazic SE, Barker RA (2014), "A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease." BMC Neurol 14:35 Details
Geurtsen GJ, Hoogland J, Goldman JG, Schmand BA, Tr�ster AI, Burn DJ, Litvan I, MDS Study Group on the Validation of PD-MCI Criteria (2014), "Parkinson's disease mild cognitive impairment: application and validation of the criteria." J Parkinsons Dis 4(2):131-7 Details
Goldman JG, Williams-Gray C, Barker RA, Duda JE, Galvin JE (2014), "The spectrum of cognitive impairment in Lewy body diseases." Mov Disord 29(5):608-21 Details
Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG (2014), "Anti-amyloid compounds inhibit ?-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA)." J Biol Chem 289(17):11897-905 Details
Huefner A, Septiadi D, Wilts BD, Patel II, Kuan WL, Fragniere A, Barker RA, Mahajan S (2014), "Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes." Methods 68(2):354-63 Details
Kehagia AA, Housden CR, Regenthal R, Barker RA, M�ller U, Rowe J, Sahakian BJ, Robbins TW (2014), "Targeting impulsivity in Parkinson's disease using atomoxetine." Brain 137(Pt 7):1986-97 Details
Lawson RA, Yarnall AJ, Duncan GW, Khoo TK, Breen DP, Barker RA, Collerton D, Taylor JP, Burn DJ (2014), "Quality of Life and Mild Cognitive Impairment in Early Parkinson's Disease: Does Subtype Matter?" J Parkinsons Dis Details
Long JD, Paulsen JS, Marder K, Zhang Y, Kim JI, Mills JA, Researchers of the PREDICT-HD Huntington's Study Group (2014), "Tracking motor impairments in the progression of Huntington's disease." Mov Disord 29(3):311-9 Details
Moore SF, Barker RA (2014), "Predictors of Parkinson's disease dementia: towards targeted therapies for a heterogeneous disease." Parkinsonism Relat Disord 20 Suppl 1:S104-7 Details
Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugi�res P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA (2014), "Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial." Lancet Details
Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ, ICICLE-PD Study Group (2014), "Characterizing mild cognitive impairment in incident Parkinson disease: The ICICLE-PD Study." Neurology 82(4):308-16 Details
Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), "Improving Response Inhibition in Parkinson's Disease with Atomoxetine." Biol Psychiatry Details
Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), "Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease." Brain 137(Pt 4):1145-55 Details
Ali F, Stott SR, Barker RA (2013), "Stem cells and the treatment of Parkinson's disease." Exp Neurol Details
Antoniades CA, Xu Z, Carpenter RH, Barker RA (2013), "The relationship between abnormalities of saccadic and manual response times in Parkinson's disease." J Parkinsons Dis 3(4):557-63 Details
Barker RA, Barrett J, Mason SL, Bj�rklund A (2013), "Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease." Lancet Neurol 12(1):84-91 Details
Barker RA, de Beaufort I (2013), "Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain." Prog Neurobiol 110:63-73 Details
Barker RA, Filippi M, Strupp M (2013), "Journal of Neurology: ready for continued success." J Neurol 260(1):1-2 Details
Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, Armstrong RJ, Tyers P, Smith E, Carpenter A, Piccini P, Tai YF, Brooks DJ, Pavese N, Watts C, Pickard JD, Rosser AE, Dunnett SB, NEST-UK collaboration (2013), "The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease." J Neurol Neurosurg Psychiatry 84(6):657-65 Details
Barker RA, Stacy M, Brundin P (2013), "A new approach to disease-modifying drug trials in Parkinson's disease." J Clin Invest 123(6):2364-5 Details
Begeti F, Tan AY, Cummins GA, Collins LM, Guzman NV, Mason SL, Barker RA (2013), "The Addenbrooke's Cognitive Examination-Revised accurately detects cognitive decline in Huntington's disease." J Neurol 260(11):2777-85 Details
Bonner-Jackson A, Long JD, Westervelt H, Tremont G, Aylward E, Paulsen JS, PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2013), "Cognitive reserve and brain reserve in prodromal Huntington's Disease." J Int Neuropsychol Soc 19(7):739-50 Details
Breen DP, Evans JR, Farrell K, Brayne C, Barker RA (2013), "Determinants of delayed diagnosis in Parkinson's disease." J Neurol 260(8):1978-81 Details
Breen DP, Williams-Gray CH, Mason SL, Foltynie T, Barker RA (2013), "Excessive daytime sleepiness and its risk factors in incident Parkinson's disease." J Neurol Neurosurg Psychiatry 84(2):233-4 Details
Brundin P, Barker RA, Conn PJ, Dawson TM, Kieburtz K, Lees AJ, Schwarzschild MA, Tanner CM, Isaacs T, Duffen J, Matthews H, Wyse RK (2013), "Linked clinical trials--the development of new clinical learning studies in Parkinson's disease using screening of multiple prospective new treatments." J Parkinsons Dis 3(3):231-9 Details
Burn DJ, Barker RA (2013), "Mild cognitive impairment in Parkinson's disease: millstone or milestone?" Pract Neurol 13(2):68-9 Details
Carri AD, Onorati M, Lelos MJ, Castiglioni V, Faedo A, Menon R, Camnasio S, Vuono R, Spaiardi P, Talpo F, Toselli M, Martino G, Barker RA, Dunnett SB, Biella G, Cattaneo E (2013), "Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons." Development 140(2):301-12 Details
Cisbani G, Freeman TB, Soulet D, Saint-Pierre M, Gagnon D, Parent M, Hauser RA, Barker RA, Cicchetti F (2013), "Striatal allografts in patients with Huntington's disease: impact of diminished astrocytes and vascularization on graft viability." Brain 136(Pt 2):433-43 Details
Drouin-Ouellet J, Barker RA (2013), "The challenges of administering cell-based therapies to patients with Parkinson's disease." Neuroreport 24(18):1000-4 Details
Duncan GW, Khoo TK, Coleman SY, Brayne C, Yarnall AJ, O'Brien JT, Barker RA, Burn DJ (2013), "The incidence of Parkinson's disease in the North-East of England." Age Ageing Details
Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Coleman SY, Brooks DJ, Barker RA, Burn DJ (2013), "Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms." Mov Disord Details
Ellul MA, Cross J, Barker RA (2013), "L-dopa responsive parkinsonism secondary to a subdural haematoma." J Clin Neurosci 20(7):1022-4 Details
Epping EA, Mills JA, Beglinger LJ, Fiedorowicz JG, Craufurd D, Smith MM, Groves M, Bijanki KR, Downing N, Williams JK, Long JD, Paulsen JS, PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2013), "Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study." J Psychiatr Res 47(10):1423-31 Details
Fallon SJ, Hampshire A, Williams-Gray CH, Barker RA, Owen AM (2013), "Putative cortical dopamine levels affect cortical recruitment during planning." Neuropsychologia 51(11):2194-201 Details
HORIZON Investigators of the Huntington Study Group and European Huntington's Disease Network (2013), "A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease." JAMA Neurol 70(1):25-33 Details
Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Bernhard Landwehrmeyer G, van der Mast RC, Giltay EJ, REGISTRY investigators of the European Huntington's Disease Network (2013), "Suicidal ideation in a European Huntington's disease population." J Affect Disord 151(1):248-58 Details
Hudson G, Nalls M, Evans JR, Breen DP, Winder-Rhodes S, Morrison KE, Morris HR, Williams-Gray CH, Barker RA, Singleton AB, Hardy J, Wood NE, Burn DJ, Chinnery PF (2013), "Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease." Neurology 80(22):2042-8 Details
Huefner A, Kuan WL, Barker RA, Mahajan S (2013), "Intracellular SERS nanoprobes for distinction of different neuronal cell types." Nano Lett 13(6):2463-70 Details
Kehagia AA, Barker RA, Robbins TW (2013), "Cognitive impairment in Parkinson's disease: the dual syndrome hypothesis." Neurodegener Dis 11(2):79-92 Details
Khoo TK, Yarnall AJ, Duncan GW, Coleman S, O'Brien JT, Brooks DJ, Barker RA, Burn DJ (2013), "The spectrum of nonmotor symptoms in early Parkinson disease." Neurology 80(3):276-81 Details
Larsen AT, Ohlsson AG, Polentarutti B, Barker RA, Phillips AR, Abu-Rmaileh R, Dickinson PA, Abrahamsson B, Ostergaard J, M�llertz A (2013), "Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation." Eur J Pharm Sci 48(1-2):339-50 Details
Metzger S, Walter C, Riess O, Roos RA, Nielsen JE, Craufurd D, REGISTRY Investigators of the European Huntington�s Disease Network, Nguyen HP (2013), "The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients." PLoS One 8(7):e68951 Details
Nombela C, Rae CL, Grahn JA, Barker RA, Owen AM, Rowe JB (2013), "How often does music and rhythm improve patients' perception of motor symptoms in Parkinson's disease?" J Neurol 260(5):1404-5 Details
Rittman T, Ghosh BC, McColgan P, Breen DP, Evans J, Williams-Gray CH, Barker RA, Rowe JB (2013), "The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders." J Neurol Neurosurg Psychiatry 84(5):544-51 Details
Stott SR, Barker RA (2013), "Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease." Eur J Neurosci Details
Thompson JA, Cruickshank TM, Penailillo LE, Lee JW, Newton RU, Barker RA, Ziman MR (2013), "The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington's disease: a pilot study." Eur J Neurol 20(9):1325-9 Details
Weerasinghe AJ, Amin SA, Barker RA, Othman T, Romano AN, Parker Siburt CJ, Tisnado J, Lambert LA, Huxford T, Carrano CJ, Crumbliss AL (2013), "Borate as a synergistic anion for Marinobacter algicola ferric binding protein, FbpA: a role for boron in iron transport in marine life." J Am Chem Soc 135(39):14504-7 Details
Whitworth SR, Loftus AM, Skinner TC, Gasson N, Barker RA, Bucks RS, Thomas MG (2013), "Personality affects aspects of health-related quality of life in Parkinson's disease via psychological coping strategies." J Parkinsons Dis 3(1):45-53 Details
Williams-Gray CH, Mason SL, Evans JR, Foltynie T, Brayne C, Robbins TW, Barker RA (2013), "The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort." J Neurol Neurosurg Psychiatry 84(11):1258-64 Details
Winder-Rhodes SE, Evans JR, Ban M, Mason SL, Williams-Gray CH, Foltynie T, Duran R, Mencacci NE, Sawcer SJ, Barker RA (2013), "Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort." Brain 136(Pt 2):392-9 Details
Aylward EH, Liu D, Nopoulos PC, Ross CA, Pierson RK, Mills JA, Long JD, Paulsen JS, PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2012), "Striatal volume contributes to the prediction of onset of Huntington disease in incident cases." Biol Psychiatry 71(9):822-8 Details
Barker RA (2012), "New hands at the helm." J Neurol 259(1):1-3 Details
Barker RA (2012), "The future of stem cells in neurodegenerative disorders of the central nervous system." CMAJ 184(6):631-2 Details
Barker RA (2012), "Stem cells and neurodegenerative diseases: where is it all going?" Regen Med 7(6 Suppl):26-31 Details
Brossman B, Williams JK, Downing N, Mills JA, Paulsen JS, PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2012), "Development of the Huntington disease work function scale." J Occup Environ Med 54(10):1300-8 Details
Decressac M, Barker RA (2012), "Neuropeptide Y and its role in CNS disease and repair." Exp Neurol 238(2):265-72 Details
Drouin-Ouellet J, Barker RA (2012), "Parkinson's Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson's Disease, If Anything?" Stem Cells Int 2012:926147 Details
Evans JR, Mason SL, Barker RA (2012), "Current status of clinical trials of neural transplantation in Parkinson's disease." Prog Brain Res 200:169-98 Details
Kehagia AA, Barker RA, Robbins TW (2012), "Revisiting the effects of Parkinson's disease and frontal lobe lesions on task switching: The role of rule reconfiguration." J Neuropsychol Details
Kuan WL, Poole E, Fletcher M, Karniely S, Tyers P, Wills M, Barker RA, Sinclair JH (2012), "A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity." J Exp Med 209(1):1-10 Details
Quarrell OW, Handley O, O'Donovan K, Dumoulin C, Ramos-Arroyo M, Biunno I, Bauer P, Kline M, Landwehrmeyer GB, European Huntington�s Disease Network (2012), "Discrepancies in reporting the CAG repeat lengths for Huntington's disease." Eur J Hum Genet 20(1):20-6 Details
Winder-Rhodes SE, Garcia-Reitb�ck P, Ban M, Evans JR, Jacques TS, Kemppinen A, Foltynie T, Williams-Gray CH, Chinnery PF, Hudson G, Burn DJ, Allcock LM, Sawcer SJ, Barker RA, Spillantini MG (2012), "Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome." Mov Disord 27(2):312-5 Details
Barker RA, Mason SL (2011), "Neurodegenerative disease: Tracking disease progress in Huntington disease." Nat Rev Neurol 7(4):192-3 Details
Breen DP, Michell AW, Barker RA (2011), "Parkinson's disease--the continuing search for biomarkers." Clin Chem Lab Med 49(3):393-401 Details
Breen DP, Rowe JB, Barker RA (2011), "Role of brain imaging in early parkinsonism." BMJ 342:d638 Details
Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Chandran S, Caldwell MA (2011), "Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells." Cell Death Differ 18(5):907-13 Details
de Yebenes JG, Landwehrmeyer B, Squitieri F, Reilmann R, Rosser A, Barker RA, Saft C, Magnet MK, Sword A, Rembratt A, Tedroff J, MermaiHD study investigators (2011), "Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial." Lancet Neurol 10(12):1049-57 Details
Dyson SC, Barker RA (2011), "Cell-based therapies for Parkinson's disease." Expert Rev Neurother 11(6):831-44 Details
Evans JR, Barker RA (2011), "Defining meaningful outcome measures in trials of disease-modifying therapies in Parkinson's disease." Expert Opin Pharmacother 12(8):1249-58 Details
Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Brayne C, Robbins TW, Barker RA (2011), "The natural history of treated Parkinson's disease in an incident, community based cohort." J Neurol Neurosurg Psychiatry 82(10):1112-8 Details
Goodman AO, Barker RA (2011), "Body composition in premanifest Huntington's disease reveals lower bone density compared to controls." PLoS Curr 3:RRN1214 Details
Goodman AO, Rogers L, Pilsworth S, McAllister CJ, Shneerson JM, Morton AJ, Barker RA (2011), "Asymptomatic sleep abnormalities are a common early feature in patients with Huntington's disease." Curr Neurol Neurosci Rep 11(2):211-7 Details
Laguna Goya R, Busch R, Mathur R, Coles AJ, Barker RA (2011), "Human fetal neural precursor cells can up-regulate MHC class I and class II expression and elicit CD4 and CD8 T cell proliferation." Neurobiol Dis 41(2):407-14 Details
McKenzie K, Barker RA, Scott DA, Strachan DA (2011), "Use of routine health data to complement monitoring of consumer product-related injuries." Med J Aust 195(10):580-1 Details
Nopoulos PC, Aylward EH, Ross CA, Mills JA, Langbehn DR, Johnson HJ, Magnotta VA, Pierson RK, Beglinger LJ, Nance MA, Barker RA, Paulsen JS, PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2011), "Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment." Brain 134(Pt 1):137-42 Details
O'Keeffe GC, Barker RA (2011), "Dopamine stimulates epidermal growth factor release from adult neural precursor cells derived from the subventricular zone by a disintegrin and metalloprotease." Neuroreport 22(18):956-8 Details
Perneczky R, Ghosh BC, Hughes L, Carpenter RH, Barker RA, Rowe JB (2011), "Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity." Neurobiol Dis 43(1):79-85 Details
Politis M, Pavese N, Tai YF, Kiferle L, Mason SL, Brooks DJ, Tabrizi SJ, Barker RA, Piccini P (2011), "Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study." Hum Brain Mapp 32(2):258-70 Details
UK Parkinson's Disease Consortium, Wellcome Trust Case Control Consortium 2, Spencer CC, Plagnol V, Strange A, Gardner M, Paisan-Ruiz C, Band G, Barker RA, Bellenguez C, Bhatia K, Blackburn H, Blackwell JM, Bramon E, Brown MA, Brown MA, Burn D, Casas JP, Chinnery PF, Clarke CE, Corvin A, Craddock N, Deloukas P, Edkins S, Evans J, Freeman C, Gray E, Hardy J, Hudson G, Hunt S, Jankowski J, Langford C, Lees AJ, Markus HS, Mathew CG, McCarthy MI, Morrison KE, Palmer CN, Pearson JP, Peltonen L, Pirinen M, Plomin R, Potter S, Rautanen A, Sawcer SJ, Su Z, Trembath RC, Viswanathan AC, Williams NW, Morris HR, Donnelly P, Wood NW (2011), "Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21." Hum Mol Genet 20(2):345-53 Details
Wijeyekoon R, Barker RA (2011), "The Current Status of Neural Grafting in the Treatment of Huntington's Disease. A Review." Front Integr Neurosci 5:78 Details
Breen DP, Barker RA (2010), "Parkinson's disease and 2009: recent advances." J Neurol Details
Decressac M, Wright B, David B, Tyers P, Jaber M, Barker RA, Gaillard A (2010), "Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis." Hippocampus Details
Goodman AO, Barker RA (2010), "How vital is sleep in Huntington's disease?" J Neurol Details
Goodman AO, Morton AJ, Barker RA (2010), "Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire." PLoS Curr 2:RRN1189 Details
Hobbs NZ, Barnes J, Frost C, Henley SM, Wild EJ, Macdonald K, Barker RA, Scahill RI, Fox NC, Tabrizi SJ (2010), "Onset and Progression of Pathologic Atrophy in Huntington Disease: A Longitudinal MR Imaging Study." AJNR Am J Neuroradiol Details
Hughes LE, Barker RA, Owen AM, Rowe JB (2010), "Parkinson's disease and healthy aging: Independent and interacting effects on action selection." Hum Brain Mapp Details
Kieburtz K, McDermott MP, Voss TS, Corey-Bloom J, Deuel LM, Dorsey ER, Factor S, Geschwind MD, Hodgeman K, Kayson E, Noonberg S, Pourfar M, Rabinowitz K, Ravina B, Sanchez-Ramos J, Seely L, Walker F, Feigin A, Dimebon in Subjects with Huntington Disease (DIMOND) Investigators of the Huntington Study Group (2010), "A randomized, placebo-controlled trial of latrepirdine in Huntington disease." Arch Neurol 67(2):154-60 Details
Laguna Goya R, Tyers P, Barker RA (2010), "Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice." Neuroreport 21(5):349-53 Details
Langbehn DR, Hayden MR, Paulsen JS, PREDICT-HD Investigators of the Huntington Study Group (2010), "CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches." Am J Med Genet B Neuropsychiatr Genet 153B(2):397-408 Details
Pavese N, Politis M, Tai YF, Barker RA, Tabrizi SJ, Mason SL, Brooks DJ, Piccini P (2010), "Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers." Neurobiol Dis 37(2):356-61 Details
Rowe JB, Hughes LE, Barker RA, Owen AM (2010), "Dynamic causal modelling of effective connectivity from fMRI: Are results reproducible and sensitive to Parkinson's disease and its treatment?" Neuroimage Details
Aziz NA, Jurgens CK, Landwehrmeyer GB, EHDN Registry Study Group, van Roon-Mom WM, van Ommen GJ, Stijnen T, Roos RA (2009), "Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease." Neurology 73(16):1280-5 Details
Barker RA (2009), "Parkinson's disease and growth factors - are they the answer?" Parkinsonism Relat Disord 15 Suppl 3:S181-4 Details
Barker RA, Michell AW (2009), ""The eyes have it". Saccadometry and Parkinson's disease." Exp Neurol Details
Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, Carlozzi NE, Duff K, Beglinger LJ, Paulsen JS, PREDICT-HD Investigators of the Huntington Study Group (2009), "Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study." Mov Disord 24(12):1763-72 Details
Cools R, Rogers R, Barker RA, Robbins TW (2009), "Top-Down Attentional Control in Parkinson's Disease: Salient Considerations." J Cogn Neurosci Details
Foltynie T, Cheeran B, Williams-Gray CH, Edwards MJ, Schneider SA, Weinberger D, Rothwell JC, Barker RA, Bhatia KP (2009), "BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease." J Neurol Neurosurg Psychiatry 80(2):141-4 Details
Henley SM, Wild EJ, Hobbs NZ, Frost C, MacManus DG, Barker RA, Fox NC, Tabrizi SJ (2009), "Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease." Mov Disord 24(6):932-6 Details
Henley SM, Wild EJ, Hobbs NZ, Scahill RI, Ridgway GR, Macmanus DG, Barker RA, Fox NC, Tabrizi SJ (2009), "Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease." J Neurol 256(2):203-12 Details
Ho AK, Gilbert AS, Mason SL, Goodman AO, Barker RA (2009), "Health-related quality of life in Huntington's disease: Which factors matter most?" Mov Disord 24(4):574-8 Details
Hobbs NZ, Henley SM, Wild EJ, Leung KK, Frost C, Barker RA, Scahill RI, Barnes J, Tabrizi SJ, Fox NC (2009), "Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease." Neuroimage 47(4):1659-65 Details
Kehagia AA, Cools R, Barker RA, Robbins TW (2009), "Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson's disease." Neuropsychologia 47(4):1117-27 Details
Lazic SE, Mason SL, Michell AW, Barker RA (2009), "Visualising disease progression on multiple variables with vector plots and path plots." BMC Med Res Methodol 9:32 Details
Lewis SJ, Barker RA (2009), "Understanding the dopaminergic deficits in Parkinson's disease: insights into disease heterogeneity." J Clin Neurosci 16(5):620-5 Details
Lewis SJ, Barker RA (2009), "A pathophysiological model of freezing of gait in Parkinson's disease." Parkinsonism Relat Disord 15(5):333-8 Details
Mason SL, Barker RA (2009), "Emerging drug therapies in Huntington's disease." Expert Opin Emerg Drugs 14(2):273-97 Details
O'Keeffe GC, Michell AW, Barker RA (2009), "Biomarkers in Huntington's and Parkinson's Disease." Ann N Y Acad Sci 1180:97-110 Details
O'Keeffe GI, Barker RA, Caldwell MA (2009), "Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain." Cell Cycle 8(18) Details
Phillips W, Michell A, Pruess H, Barker RA (2009), "Animal models of neurodegenerative diseases." Methods Mol Biol 549:137-55 Details
Thomas M, Tyers P, Lazic SE, Barker RA, Beazley L, Ziman M (2009), "Graft outcomes influenced by co-expression of Pax7 in graft and host tissue." J Anat 214(3):396-405 Details
Wijeyekoon R, Barker RA (2009), "Cell replacement therapy for Parkinson's disease." Biochim Biophys Acta 1792(7):688-702 Details
Williams-Gray C, Goris A, Foltynie T, Compston A, Sawcer S, Barker RA (2009), "No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson's disease." J Neurol 256(1):132-3 Details
Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA (2009), "The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort." Brain 132(Pt 11):2958-69 Details
Williams-Gray CH, Goris A, Saiki M, Foltynie T, Compston DA, Sawcer SJ, Barker RA (2009), "Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease." J Neurol 256(3):493-8 Details
Antoniades CA, Barker RA (2008), "The search for biomarkers in Parkinson's disease: a critical review." Expert Rev Neurother 8(12):1841-52 Details
Blackwell AD, Paterson NS, Barker RA, Robbins TW, Sahakian BJ (2008), "The effects of modafinil on mood and cognition in Huntington's disease." Psychopharmacology (Berl) Details
Clelland CD, Barker RA, Watts C (2008), "Cell therapy in Huntington disease." Neurosurg Focus 24(3-4):E9 Details
Evans JR, Barker RA (2008), "Neurotrophic factors as a therapeutic target for Parkinson's disease." Expert Opin Ther Targets 12(4):437-47 Details
Goodman AO, Murgatroyd PR, Medina-Gomez G, Wood NI, Finer N, Vidal-Puig AJ, Morton AJ, Barker RA (2008), "The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study." Exp Neurol 210(2):691-8 Details
Henley SM, Wild EJ, Hobbs NZ, Warren JD, Frost C, Scahill RI, Ridgway GR, MacManus DG, Barker RA, Fox NC, Tabrizi SJ (2008), "Defective emotion recognition in early HD is neuropsychologically and anatomically generic." Neuropsychologia 46(8):2152-60 Details
Kuan WL, Zhao JW, Barker RA (2008), "The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram." Psychopharmacology (Berl) 197(2):279-93 Details
Laguna Goya R, Tyers P, Barker RA (2008), "The search for a curative cell therapy in Parkinson's disease." J Neurol Sci 265(1-2):32-42 Details
Mercy L, Hodges JR, Dawson K, Barker RA, Brayne C (2008), "Incidence of early-onset dementias in Cambridgeshire, United Kingdom." Neurology 71(19):1496-9 Details
Michell AW, Goodman AO, Silva AH, Lazic SE, Morton AJ, Barker RA (2008), "Hand tapping: a simple, reproducible, objective marker of motor dysfunction in Huntington's disease." J Neurol 255(8):1145-52 Details
Phillips W, Shannon KM, Barker RA (2008), "The current clinical management of Huntington's disease." Mov Disord 23(11):1491-504 Details
Politis M, Pavese N, Tai YF, Tabrizi SJ, Barker RA, Piccini P (2008), "Hypothalamic involvement in Huntington's disease: an in vivo PET study." Brain 131(Pt 11):2860-9 Details
Quinn N, Barker RA, Wenning GK (2008), "Are trials of intravascular infusions of autologous mesenchymal stem cells in patients with multiple system atrophy currently justified, and are they effective?" Clin Pharmacol Ther 83(5):663-5 Details
Reuter I, Tai YF, Pavese N, Chaudhuri KR, Mason S, Polkey CE, Clough C, Brooks DJ, Barker RA, Piccini P (2008), "Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease." J Neurol Neurosurg Psychiatry 79(8):948-51 Details
Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM (2008), "Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition." Brain 131(Pt 8):2094-105 Details
Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM (2008), "The val(158)met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease." Neurobiol Aging Details
Thompson SA, Calvin J, Hogg S, Ferdinandusse S, Wanders RJ, Barker RA (2008), "Relapsing encephalopathy in a patient with alpha-methylacyl-CoA racemase deficiency." J Neurol Neurosurg Psychiatry 79(4):448-50 Details
Wedderburn C, Wear H, Brown J, Mason SJ, Barker RA, Hodges J, Williams-Gray C (2008), "The utility of the Cambridge Behavioural Inventory in neurodegenerative disease." J Neurol Neurosurg Psychiatry 79(5):500-3 Details
Williams-Gray CH, Hampshire A, Barker RA, Owen AM (2008), "Attentional control in Parkinson's disease is dependent on COMT val 158 met genotype." Brain 131(Pt 2):397-408 Details
Wood NI, Goodman AO, van der Burg JM, Gazeau V, Brundin P, Bj�rkqvist M, Peters�n A, Tabrizi SJ, Barker RA, Jennifer Morton A (2008), "Increased thirst and drinking in Huntington's disease and the R6/2 mouse." Brain Res Bull 76(1-2):70-9 Details
Antoniades CA, Altham PM, Mason SL, Barker RA, Carpenter R (2007), "Saccadometry: a new tool for evaluating presymptomatic Huntington patients." Neuroreport 18(11):1133-6 Details
Cools R, Lewis SJ, Clark L, Barker RA, Robbins TW (2007), "L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease." Neuropsychopharmacology 32(1):180-9 Details
Goris A, Williams-Gray CH, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Barker RA, Sawcer SJ (2007), "Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease." J Neurol 254(7):846-8 Details
Goya RL, Kuan WL, Barker RA (2007), "The future of cell therapies in the treatment of Parkinson's disease." Expert Opin Biol Ther 7(10):1487-98 Details
Kuan WL, Lin R, Tyers P, Barker RA (2007), "The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias." Neurobiol Dis 25(3):594-608 Details
Lawrence AJ, Blackwell AD, Barker RA, Spagnolo F, Clark L, Aitken MR, Sahakian BJ (2007), "Predictors of punding in Parkinson's disease: results from a questionnaire survey." Mov Disord 22(16):2339-45 Details
Lazic SE, Goodman AO, Grote HE, Blakemore C, Morton AJ, Hannan AJ, van Dellen A, Barker RA (2007), "Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients." Brain Res 1151:219-26 Details
Michell AW, Tofaris GK, Gossage H, Tyers P, Spillantini MG, Barker RA (2007), "The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease." Cell Transplant 16(5):461-74 Details
Tai YF, Pavese N, Gerhard A, Tabrizi SJ, Barker RA, Brooks DJ, Piccini P (2007), "Microglial activation in presymptomatic Huntington's disease gene carriers." Brain 130(Pt 7):1759-66 Details
Tai YF, Pavese N, Gerhard A, Tabrizi SJ, Barker RA, Brooks DJ, Piccini P (2007), "Imaging microglial activation in Huntington's disease." Brain Res Bull 72(2-3):148-51 Details
Thomas MG, Barker RA, Beazley LD, Ziman MR (2007), "Pax7 expression in the adult rat superior colliculus following optic nerve injury." Neuroreport 18(2):105-9 Details
Williams-Gray CH, Barker RA (2007), "Visual hallucinations predict increased benefits from rivastigmine in Parkinson's disease dementia." Nat Clin Pract Neurol 3(5):250-1 Details
Williams-Gray CH, Foltynie T, Brayne CE, Robbins TW, Barker RA (2007), "Evolution of cognitive dysfunction in an incident Parkinson's disease cohort." Brain 130(Pt 7):1787-98 Details
Williams-Gray CH, Hampshire A, Robbins TW, Owen AM, Barker RA (2007), "Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease." J Neurosci 27(18):4832-8 Details
Wright BL, Barker RA (2007), "Established and emerging therapies for Huntington's disease." Curr Mol Med 7(6):579-87 Details
Ali FR, Michell AW, Barker RA, Carpenter RH (2006), "The use of quantitative oculometry in the assessment of Huntington's disease." Exp Brain Res 169(2):237-45 Details
Barker RA (2006), "Continuing trials of GDNF in Parkinson's disease." Lancet Neurol 5(4):285-6 Details
Farrington M, Wreghitt TG, Lever AM, Dunnett SB, Rosser AE, Barker RA (2006), "Neural transplantation in Huntington's disease: the NEST-UK donor tissue microbiological screening program and review of the literature." Cell Transplant 15(4):279-94 Details
Goris A, Williams-Gray CH, Foltynie T, Compston DA, Barker RA, Sawcer SJ (2006), "No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening." Am J Hum Genet 78(6):1088-90; author reply 1092-4 Details
Harrower TP, Tyers P, Hooks Y, Barker RA (2006), "Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease." Exp Neurol 197(1):56-69 Details
Heath CA, Barker RA, Esmonde TF, Harvey P, Roberts R, Trend P, Head MW, Smith C, Bell JE, Ironside JW, Will RG, Knight RS (2006), "Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK." J Neurol Neurosurg Psychiatry 77(7):880-2 Details
Ho AK, Robbins AO, Barker RA (2006), "Huntington's disease patients have selective problems with insight." Mov Disord 21(3):385-9 Details
Jain M, Armstrong RJ, Elneil S, Barker RA (2006), "Transplanted human neural precursor cells migrate widely but show no lesion-specific tropism in the 6-hydroxydopamine rat model of Parkinson's disease." Cell Transplant 15(7):579-93 Details
Kuan WL, Hurelbrink CB, Barker RA (2006), "Increased capacity for axonal outgrowth using xenogenic tissue in vitro and in a rodent model of Parkinson's disease." Xenotransplantation 13(3):233-47 Details
Lazic SE, Grote HE, Blakemore C, Hannan AJ, van Dellen A, Phillips W, Barker RA (2006), "Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment." Eur J Neurosci 23(7):1829-38 Details
Michell AW, Xu Z, Fritz D, Lewis SJ, Foltynie T, Williams-Gray CH, Robbins TW, Carpenter RH, Barker RA (2006), "Saccadic latency distributions in Parkinson's disease and the effects of L-dopa." Exp Brain Res 174(1):7-18 Details
Pavese N, Gerhard A, Tai YF, Ho AK, Turkheimer F, Barker RA, Brooks DJ, Piccini P (2006), "Microglial activation correlates with severity in Huntington disease: a clinical and PET study." Neurology 66(11):1638-43 Details
Phillips W, Jennifer Morton A, Barker RA (2006), "Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease." Neuroreport 17(15):1623-7 Details
Phillips W, Michell AW, Barker RA (2006), "Neurogenesis in diseases of the central nervous system." Stem Cells Dev 15(3):359-79 Details
Robbins AO, Ho AK, Barker RA (2006), "Weight changes in Huntington's disease." Eur J Neurol 13(8):e7 Details
Slabosz A, Lewis SJ, Smigasiewicz K, Szymura B, Barker RA, Owen AM (2006), "The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease." Neuropsychology 20(5):578-88 Details
Swainson R, SenGupta D, Shetty T, Watkins LH, Summers BA, Sahakian BJ, Polkey CE, Barker RA, Robbins TW (2006), "Impaired dimensional selection but intact use of reward feedback during visual discrimination learning in Parkinson's disease." Neuropsychologia 44(8):1290-304 Details
Underwood BR, Broadhurst D, Dunn WB, Ellis DI, Michell AW, Vacher C, Mosedale DE, Kell DB, Barker RA, Grainger DJ, Rubinsztein DC (2006), "Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles." Brain 129(Pt 4):877-86 Details
Williams-Gray CH, Foltynie T, Lewis SJ, Barker RA (2006), "Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options." CNS Drugs 20(6):477-505 Details
Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA (2006), "Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort." J Neurol Neurosurg Psychiatry 77(5):665-7 Details
Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA (2006), "No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease." Mov Disord 21(5):731-2 Details
Barker RA (2005), "The neurological assessment of patients in vegetative and minimally conscious states." Neuropsychol Rehabil 15(3-4):214-23 Details
Cheesman AL, Barker RA, Lewis SJ, Robbins TW, Owen AM, Brooks DJ (2005), "Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease." J Neurol Neurosurg Psychiatry 76(9):1204-10 Details
Foltynie T, Hicks A, Sawcer S, Jonasdottir A, Setakis E, Maranian M, Yeo T, Lewis S, Brayne C, Stefansson K, Compston A, Gulcher J, Barker RA (2005), "A genome wide linkage disequilibrium screen in Parkinson's disease." J Neurol 252(5):597-602 Details
Foltynie T, Lewis SG, Goldberg TE, Blackwell AD, Kolachana BS, Weinberger DR, Robbins TW, Barker RA (2005), "The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease." J Neurol 252(7):833-8 Details
Harrower T, Barker RA (2005), "Cell therapies for neurological disease--from bench to clinic to bench." Expert Opin Biol Ther 5(3):289-91 Details
Harrower TP, Michell AW, Barker RA (2005), "Lewy bodies in Parkinson's disease: protectors or perpetrators?" Exp Neurol 195(1):1-6 Details
Hurelbrink CB, Barker RA (2005), "Migration of cells from primary transplants of allo- and xenografted foetal striatal tissue in the adult rat brain." Eur J Neurosci 21(6):1503-10 Details
Hurelbrink CB, Lewis SJ, Barker RA (2005), "The use of the Actiwatch-Neurologica system to objectively assess the involuntary movements and sleep-wake activity in patients with mild-moderate Huntington's disease." J Neurol 252(6):642-7 Details
Kuan WL, Barker RA (2005), "New therapeutic approaches to Parkinson's disease including neural transplants." Neurorehabil Neural Repair 19(3):155-81 Details
Lewis SJ, Foltynie T, Blackwell AD, Robbins TW, Owen AM, Barker RA (2005), "Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach." J Neurol Neurosurg Psychiatry 76(3):343-8 Details
Lewis SJ, Slabosz A, Robbins TW, Barker RA, Owen AM (2005), "Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease." Neuropsychologia 43(6):823-32 Details
Longworth CE, Keenan SE, Barker RA, Marslen-Wilson WD, Tyler LK (2005), "The basal ganglia and rule-governed language use: evidence from vascular and degenerative conditions." Brain 128(Pt 3):584-96 Details
Michell AW, Barker RA, Raha SK, Raha-Chowdhury R (2005), "A case of late onset sporadic Parkinson's disease with an A53T mutation in alpha-synuclein." J Neurol Neurosurg Psychiatry 76(4):596-7 Details
Michell AW, Luheshi LM, Barker RA (2005), "Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease." Neurosci Lett 381(3):294-8 Details
Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES (2005), "Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease." J Neurosci 25(1):157-63 Details
Phillips W, Morton AJ, Barker RA (2005), "Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment." J Neurosci 25(50):11564-76 Details
Barker RA, Foltynie T (2004), "The future challenges in Parkinson's disease." J Neurol 251(3):361-5 Details
Barker RA, Widner H (2004), "Immune problems in central nervous system cell therapy." NeuroRx 1(4):472-81 Details
Foltynie T, Brayne CE, Robbins TW, Barker RA (2004), "The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study." Brain 127(Pt 3):550-60 Details
Foltynie T, Goldberg TE, Lewis SG, Blackwell AD, Kolachana BS, Weinberger DR, Robbins TW, Barker RA (2004), "Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism." Mov Disord 19(8):885-91 Details
Foltynie T, Robbins YW, Brayne C, Barker RA (2004), "Cognitive impairments are common among a population cohort of newly diagnosed PD patients - the CamPaIGN study" Brain 127:550-60
Harrower TP, Barker RA (2004), "Is there a future for neural transplantation?" BioDrugs 18(3):141-53 Details
Harrower TP, Barker RA (2004), "The emerging technologies of neural xenografting and stem cell transplantation for treating neurodegenerative disorders." Drugs Today (Barc) 40(2):171-89 Details
Harrower TP, Richards A, Cruz G, Copeman L, Dunnett SB, Barker RA (2004), "Complement regulatory proteins are expressed at low levels in embryonic human, wild type and transgenic porcine neural tissue." Xenotransplantation 11(1):60-71 Details
Ho AK, Nestor PJ, Williams GB, Bradshaw JL, Sahakian BJ, Robbins TW, Barker RA (2004), "Pseudo-neglect in Huntington's disease correlates with decreased angular gyrus density." Neuroreport 15(6):1061-4 Details
Ho AK, Robbins AO, Walters SJ, Kaptoge S, Sahakian BJ, Barker RA (2004), "Health-related quality of life in Huntington's disease: a comparison of two generic instruments, SF-36 and SIP." Mov Disord 19(11):1341-8 Details
Ho AK, Sahakian BJ, Robbins TW, Barker RA (2004), "Random number generation in patients with symptomatic and presymptomatic Huntington's disease." Cogn Behav Neurol 17(4):208-12 Details
Hurelbrink CB, Barker RA (2004), "The potential of GDNF as a treatment for Parkinson's disease." Exp Neurol 185(1):1-6 Details
Lazic SE, Barker RA (2004), "Rapid decline in motor symptoms in HD neural transplant patients prior to surgery." Brain Res Bull 63(1):83-4 Details
Lazic SE, Grote H, Armstrong RJ, Blakemore C, Hannan AJ, van Dellen A, Barker RA (2004), "Decreased hippocampal cell proliferation in R6/1 Huntington's mice." Neuroreport 15(5):811-3 Details
Lewis SJ, Dove A, Robbins TW, Barker RA, Owen AM (2004), "Striatal contributions to working memory: a functional magnetic resonance imaging study in humans." Eur J Neurosci 19(3):755-60 Details
Michell AW, Lewis SJ, Foltynie T, Barker RA (2004), "Biomarkers and Parkinson's disease." Brain 127(Pt 8):1693-705 Details
Michell AW, Phillips W, Barker RA (2004), "Can endogenous stem cells be stimulated to repair the degenerating brain?" J Pharm Pharmacol 56(10):1201-10 Details
Sayles M, Jain M, Barker RA (2004), "The cellular repair of the brain in Parkinson's disease--past, present and future." Transpl Immunol 12(3-4):321-42 Details
Wilkins A, Brown JM, Barker RA (2004), "SCA2 presenting as levodopa-responsive parkinsonism in a young patient from the United Kingdom: a case report." Mov Disord 19(5):593-5 Details
Armstrong RJ, Tyers P, Jain M, Richards A, Dunnett SB, Rosser AE, Barker RA (2003), "Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's disease." Exp Brain Res 151(2):204-17 Details
Aron AR, Watkins L, Sahakian BJ, Monsell S, Barker RA, Robbins TW (2003), "Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function." J Cogn Neurosci 15(5):629-42 Details
Barker RA, Foltynie T (2003), "How common is dementia with Lewy bodies?" J Neurol Neurosurg Psychiatry 74(6):697-8 Details
Barker RA, Jain M, Armstrong RJ, Caldwell MA (2003), "Stem cells and neurological disease." J Neurol Neurosurg Psychiatry 74(5):553-7 Details
Browne GJ, Lam LT, Barker RA (2003), "The usefulness of a modified adult protocol for the clearance of paediatric cervical spine injury in the emergency department." Emerg Med (Fremantle) 15(2):133-42 Details
Cools R, Barker RA, Sahakian BJ, Robbins TW (2003), "L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease." Neuropsychologia 41(11):1431-41 Details
Ho AK, Manly T, Nestor PJ, Sahakian BJ, Bak TH, Robbins TW, Rosser AE, Barker RA (2003), "A case of unilateral neglect in Huntington's disease." Neurocase 9(3):261-73 Details
Ho AK, Sahakian BJ, Brown RG, Barker RA, Hodges JR, An� MN, Snowden J, Thompson J, Esmonde T, Gentry R, Moore JW, Bodner T, NEST-HD Consortium (2003), "Profile of cognitive progression in early Huntington's disease." Neurology 61(12):1702-6 Details
Hurelbrink CB, Tyers P, Armstrong RJ, Dunnett SB, Barker RA, Rosser AE (2003), "Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: implications for clinical trials in Huntington's disease." Cell Transplant 12(7):687-95 Details
Jain M, Armstrong RJ, Elneil S, Rosser AE, Barker RA (2003), "Migration and differentiation of transplanted human neural precursor cells." Neuroreport 14(9):1257-62 Details
Jain M, Armstrong RJ, Tyers P, Barker RA, Rosser AE (2003), "GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitro." Exp Neurol 182(1):113-23 Details
Lazic SE, Barker RA (2003), "The future of cell-based transplantation therapies for neurodegenerative disorders." J Hematother Stem Cell Res 12(6):635-42 Details
Lewis SJ, Caldwell MA, Barker RA (2003), "Modern therapeutic approaches in Parkinson's disease." Expert Rev Mol Med 5(10):1-20 Details
Lewis SJ, Cools R, Robbins TW, Dove A, Barker RA, Owen AM (2003), "Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease." Neuropsychologia 41(6):645-54 Details
Lewis SJ, Dove A, Robbins TW, Barker RA, Owen AM (2003), "Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry." J Neurosci 23(15):6351-6 Details
Pavese N, Andrews TC, Brooks DJ, Ho AK, Rosser AE, Barker RA, Robbins TW, Sahakian BJ, Dunnett SB, Piccini P (2003), "Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study." Brain 126(Pt 5):1127-35 Details
Rosser AE, Barker RA, Armstrong RJ, Elneil S, Jain M, Hurelbrink CB, Prentice A, Carne C, Thornton S, Hutchinson H, Dunnett SB (2003), "Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's disease." Cell Transplant 12(7):679-86 Details
Armstrong RJ, Hurelbrink CB, Tyers P, Ratcliffe EL, Richards A, Dunnett SB, Rosser AE, Barker RA (2002), "The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease." Exp Neurol 175(1):98-111 Details
Barker RA (2002), "Repairing the brain in Parkinson's disease: where next?" Mov Disord 17(2):233-41 Details
Cools R, Stefanova E, Barker RA, Robbins TW, Owen AM (2002), "Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET." Brain 125(Pt 3):584-94 Details
Foltynie T, Brayne C, Barker RA (2002), "The heterogeneity of idiopathic Parkinson's disease." J Neurol 249(2):138-45 Details
Foltynie T, Sawcer S, Brayne C, Barker RA (2002), "The genetic basis of Parkinson's disease." J Neurol Neurosurg Psychiatry 73(4):363-70 Details
Harrower TP, Richards A, Cruz G, Copeman L, Dunnett SB, Barker RA (2002), "Alpha Gal is widely expressed in embryonic porcine stem cells and neural tissue." Neuroreport 13(4):481-5 Details
Ho AK, Sahakian BJ, Robbins TW, Barker RA, Rosser AE, Hodges JR (2002), "Verbal fluency in Huntington's disease: a longitudinal analysis of phonemic and semantic clustering and switching." Neuropsychologia 40(8):1277-84 Details
Hurelbrink CB, Armstrong RJ, Dunnett SB, Rosser AE, Barker RA (2002), "Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS." Eur J Neurosci 15(7):1255-66 Details
Rosser AE, Barker RA, Harrower T, Watts C, Farrington M, Ho AK, Burnstein RM, Menon DK, Gillard JH, Pickard J, Dunnett SB, NEST-UK (2002), "Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475." J Neurol Neurosurg Psychiatry 73(6):678-85 Details
Armstrong RJ, Barker RA (2001), "Neurodegeneration: a failure of neuroregeneration?" Lancet 358(9288):1174-6 Details
Armstrong RJ, Harrower TP, Hurelbrink CB, McLaughin M, Ratcliffe EL, Tyers P, Richards A, Dunnett SB, Rosser AE, Barker RA (2001), "Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells." Neuroscience 106(1):201-16 Details
Barker RA (2001), "Getting to the heart of dementia." J Neurol Neurosurg Psychiatry 71(5):574-5 Details
Barker RA, Rosser AE (2001), "Neural transplantation therapies for Parkinson's and Huntington's diseases." Drug Discov Today 6(11):575-582 Details
Cools R, Barker RA, Sahakian BJ, Robbins TW (2001), "Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands." Cereb Cortex 11(12):1136-43 Details
Cools R, Barker RA, Sahakian BJ, Robbins TW (2001), "Mechanisms of cognitive set flexibility in Parkinson's disease." Brain 124(Pt 12):2503-12 Details
Hurelbrink CB, Armstrong RJ, Luheshi LM, Dunnett SB, Rosser AE, Barker RA (2001), "Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation." Exp Neurol 171(1):46-58 Details
Hurelbrink CB, Barker RA (2001), "Prospects for the treatment of Parkinson's disease using neurotrophic factors." Expert Opin Pharmacother 2(10):1531-43 Details
Jain M, Armstrong RJ, Barker RA, Rosser AE (2001), "Cellular and molecular aspects of striatal development." Brain Res Bull 55(4):533-40 Details
Barker RA (2000), "Prospects for the treatment of Parkinson's disease using neural grafts." Expert Opin Pharmacother 1(5):889-902 Details
Barker RA (2000), "Porcine neural xenografts: what are the issues?" Novartis Found Symp 231:184-96; discussion 196-201, 302-6 Details
Barker RA, Kendall AL, Widner H (2000), "Neural tissue xenotransplantation: what is needed prior to clinical trials in Parkinson's disease? Neural Tissue Xenografting Project." Cell Transplant 9(2):235-46 Details
Barker RA, Ratcliffe E, McLaughlin M, Richards A, Dunnett SB (2000), "A role for complement in the rejection of porcine ventral mesencephalic xenografts in a rat model of Parkinson's disease." J Neurosci 20(9):3415-24 Details
Hurelbrink CB, Armstrong RJ, Barker RA, Dunnett SB, Rosser AE (2000), "Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease." Cell Transplant 9(6):743-9 Details
Barker RA, Anderson JR, Meyer P, Dick DJ, Scolding NJ (1999), "Microangiopathy of the brain and retina with hearing loss in a 50 year old woman: extending the spectrum of Susac's syndrome." J Neurol Neurosurg Psychiatry 66(5):641-3 Details
Barker RA, Dick DJ, Cochius JI (1999), "Delayed postanoxic encephalopathy and pseudodeficiency of arylsulphatase A." J Neurol 246(11):1103-4 Details
Barker RA, Dunnett SB (1999), "Functional integration of neural grafts in Parkinson's disease." Nat Neurosci 2(12):1047-8 Details
Barker RA, Dunnett SB, Richards A (1999), "The rejection of neural xenotransplants: a role for antibodies." Transplantation 68(8):1091-2 Details
Barker RA, Ratcliffe E, Richards A, Dunnett SB (1999), "Fetal porcine dopaminergic cell survival in vitro and its relationship to embryonic age." Cell Transplant 8(6):593-9 Details
Barker RA, Revesz T, Thom M, Marsden CD, Brown P (1998), "Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity." J Neurol Neurosurg Psychiatry 65(5):633-40 Details
Dunnett SB, Torres EM, Richards H, Barker RA (1998), "Effects of surgical anaesthesia on the viability of nigral grafts in the rat striatum." Cell Transplant 7(6):567-72 Details
Molyneux PD, Barker RA, Thom M, van Paesschen W, Harkness WF, Duncan JS (1998), "Successful treatment of intractable epilepsia partialis continua with multiple subpial transections." J Neurol Neurosurg Psychiatry 65(1):137-8 Details
Annett LE, Torres EM, Clarke DJ, Ishida Y, Barker RA, Ridley RM, Baker HF, Dunnett SB (1997), "Survival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo age." Cell Transplant 6(6):557-69 Details
Barker RA, Dunnett SB, Faissner A, Fawcett JW (1996), "The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum." Exp Neurol 141(1):79-93 Details
Fricker RA, Barker RA, Fawcett JW, Dunnett SB (1996), "A comparative study of preparation techniques for improving the viability of striatal grafts using vital stains, in vitro cultures, and in vivo grafts." Cell Transplant 5(6):599-611 Details
Barker RA, Fricker RA, Abrous DN, Fawcett J, Dunnett SB (1995), "A comparative study of preparation techniques for improving the viability of nigral grafts using vital stains, in vitro cultures, and in vivo grafts." Cell Transplant 4(2):173-200 Details
Fawcett JW, Barker RA, Dunnett SB (1995), "Dopaminergic neuronal survival and the effects of bFGF in explant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon." Exp Brain Res 106(2):275-82 Details


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…can be enjoyed at Green Street this Easter Sunday, where LUPEC President Hanky Panky has put together a special Egg Drink List in honor of the holiday.
This important ingredient of many, many classics like fizzes and flips has fallen out of misuse in the age of the Cosmo. Cocktail enthusiasts across the country are helping the mighty egg make a comeback by incorporating egg-based classics and modern vintage egg originals into their menus. The Egg Drink List offered at Green Street tomorrow evening will be a perfect opportunity to give eggs a shot. The menu will include original creations, like the Fort Washington Flip, The Brewster Sour, a variation on the Pisco Sour featuring St-Germain, and of course, the irrepressible Pink Lady.
The list is available all night long and the bar is open from 5:30 'til 1. If you aren't completely stuffed with ham or lamb, Green Street will be serving their full dinner menu from 5:30 to 10:30. There is no cover charge, and be sure to bring your patience, as egg-based drinks require time and lots and lots of shaking. A special guest shaker will accompany Hanky Panky from an undisclosed location in a very tony Boston neighborhood (can you guess who it is?)
So when you're all set with these…
You can move on to these!
Consider it a grown-up Easter Egg Hunt!
(Pink Lady photo courtesy of thinking of drinking.)


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In the five years since Sony's Alpha range was conceived, the camera market has changed decidedly. Notably, the addition of mirrorless models to many manufacturers' stables has provided an alternative means of achieving high-quality results in a small-format body.
Being no stranger to innovation itself, Sony has made its contribution with its NEX mirrrorless system and its unique SLT models, yet the four Alpha DSLRs also announced in the past year should alleviate any fears of it abandoning its original system in their favour.
Despite this, the similarities between all three of its systems and the company's Cyber-shot range of compacts aren't difficult to spot. With the same innovations eventually filtering from one system to another, the A580 isn't too great a surprise in what it offers, nor does it particularly break new technological ground.
Even so, its position in the Alpha DSLR line up places it just below Sony's full-frame Alpha 850, so it arrives with a healthy feature set and some interesting inclusions. Much is expected if it is to compete with recent APS-C offerings from the likes of Canon and Nikon. So, how does it do?


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SOCHI, Russia – The United States Olympic Committee today announced the Sochi 2014 Olympic Winter Games finalists for Best of U.S., a new awards program that recognizes outstanding performances from the Olympic and Paralympic Games, as determined by fan vote.
For the Sochi Games, winners will be selected in each of the following categories: Best Male/Female Olympian, Best Male/Female Paralympian, Team of the Olympic/Paralympic Games, Moment of the Olympic/Paralympic Games, Team Behind the Team Award and Fan of the Games Award.
Fan voting begins today (Feb. 23) at 7 p.m. EST and continues through March 21 on the Team USA Facebook page. The 10 awards will be announced during the Best of U.S. Awards Show, scheduled to air April 7 on NBCSN.
A nominating committee, comprised of USOC, athlete and media representatives, selected the finalists for the individual athlete and team categories, as well as the Moment of the Games, based on nominations from each National Governing Body.
Team USA fans can submit nominations for the Fan of the Games Award via video or photo on the Team USA Facebook page.
Joss Christensen, Freestyle Skiing
Joss Christensen became the first-ever Olympic men's slopestyle skiing champion, winning gold in its debut. His opening run score of 95.80 in the final earned him the top spot on the podium. Christensen posted the top-two scores in both the qualifying and final rounds.
Sage Kotsenburg, Snowboarding
After landing a trick he had never before attempted, Sage Kotsenburg earned the gold medal in the inaugural Olympic slopestyle snowboarding event. He scored a 93.50 when he landed a 1620 Japan with an air mute grab and the holy crail grab, which he invented. His win marked the first time a U.S. athlete secured the first gold medal of the Games since 1952.
Ted Ligety, Alpine Skiing
Ted Ligety became the first American skier to win gold in men's giant slalom and the second American to earn two gold medals in alpine skiing. In his first run, Ligety built almost a second lead and won by nearly a half a second with a total time of 2:45.29.
David Wise, Freestyle Skiing
David Wise posted a 92.00 in his first run to win gold in men's halfpipe skiing, which made its Olympic debut in Sochi. Wise landed his signature trick – the right-side double cork 360 – in the wet and heavy snow.
Jamie Anderson, Snowboarding
Jamie Anderson claimed gold in the debut of women's slopestyle snowboarding. She put together a flawless second run to secure the top podium spot with a 95.25. Her win completed the U.S. gold-medal sweep in slopestyle snowboarding.
Maddie Bowman, Freestyle Skiing
Maddie Bowman became the first-ever Olympic women's halfpipe skiing champion, taking gold in the sport's debut. She landed in the top spot with her first run score of 85.80 after executing back-to-back 900s for the first time in her career. In her second run, she extended her lead with an 89.00. Her win completed the U.S. gold-medal sweep in halfpipe skiing.
Erin Hamlin, Luge
With a bronze-medal finish, Erin Hamlin became the first-ever U.S. Olympic medalist in singles luge. The results were even more impressive considering the 2009 world champion had not stood on a world cup podium in two years. Her performance also broke a 34-year German/Austrian hold on the women's luge Olympic podium.
Mikaela Shiffrin, Alpine Skiing
Eighteen-year-old Mikaela Shiffrin became the youngest Olympic gold medalist in women's slalom. After the first run, Shiffrin led the field by 0.49 seconds and turned in a stunning second run to give her the first U.S. slalom victory since Phil Mahre in 1984 and the first women's slalom victory since Barbara Cochran in 1972.
Meryl Davis/Charlie White, Figure Skating
Meryl Davis and Charlie White captured the first U.S. ice dancing gold medal and captained Team USA to the bronze medal in the inaugural team event. The duo, which has been skating together for the last 17 years, set world-record scores in the short dance, free dance and total.
Men's USA-1, Bobsled
Steven Holcomb and Steve Langton snapped a 62-year Olympic medal drought in two-man bobsled when the pair won the bronze medal. Holcomb piloted the sled to a four-run total time of 3:46.27. Six days later, the USA-1 four-man team of Holcomb, Curt Tomasevicz, Langton and Chris Fogt captured the bronze medal in the four-man event with a total time of 3:40.99. It marked the first time in 62 years the U.S. medaled in both the two-man and four-man bobsled at a single Games.
Elana Meyers/Lauryn Williams, Bobsled
Elana Meyers and Lauryn Williams claimed the silver medal in bobsled. Meyers piloted USA-1 with a total time of 3:50.71 and is now the only U.S. bobsledder to earn an Olympic medal as a pilot and brakeman. Meanwhile, Williams made history by becoming only the second American – and fifth athlete of any nation – to medal at both the summer and winter Games.
T.J. Oshie's shootout performance against Russia
U.S. men's ice hockey player T.J. Oshie captivated America and was trending worldwide on Twitter after he scored on four-of-six shootout attempts – including the game-winner in the bottom of the eighth round – to lift the U.S. to a stirring 3-2 victory over host Russia in one of the most anticipated events of the Olympic Winter Games. Oshie began the day with 90,000 followers on Twitter and 24 hours after the game, more than doubled that number.
Men's slopestyle skiing podium sweep
Joss Christensen, Gus Kenworthy and Nick Goepper earned a U.S. podium sweep in the Olympic debut of slopestyle skiing. The sweep was only the third by Team USA in Olympic Winter Games history with the last one occurring in halfpipe snowboarding in 2002.
Noelle Pikus-Pace's medal celebration
After a career altered by injury and a fourth-place finish at the Vancouver Games, Noelle Pikus-Pace's husband encouraged her to give her Olympic dream one more shot. With her family by her side, Pikus-Pace won the silver medal in in skeleton with a four-run time of 3:53.86. The 31-year-old mother of two celebrated the victory with her husband and two kids, who were waiting at the finish line.
Men's short track 5,000m relay team earning the silver medal
In the United States' final opportunity for a speedskating medal at the Sochi Games, the U.S. men's 5,000-meter short track relay team earned the silver medal. The team of Eddy Alvarez, J.R. Celski, Chris Creveling and Jordan Malone continued Team USA's tradition of earning a speedskating medal at every Games since 1988.
Bode Miller becoming the oldest alpine skiing medalist
At 36, Bode Miller became the oldest alpine skiing medalist with his bronze-medal performance in the super-G. The bronze medal pushed Miller's Olympic medal count to six, which is second all-time in U.S. Olympic Winter Games history.


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Picture a round bronzed pastry shaped from bread dough and showered with sugar. Imagine biting into the confection, rich with butter in its many layers, and watching the roll shatter into a thousand sweet flakes.
You are eating kouign amann (say queen-ya-mahn), a delicacy from Brittany, but you are far from France. The source of this exquisite $4 pleasure: the year-old b. patisserie in San Francisco.
The "b" refers to Belinda Leong, the Bay Area pastry chef best known for her desserts at the esteemed Manresa in Los Gatos and Gary Danko in San Francisco. Kouign amann is one of many reasons to drop in at her bakery in the neighborhood of Pacific Heights. The shop's croissants rival the best in Paris.
Similar epiphanies occurred almost everywhere I ate during a winter visit to a city I used to call home and still miss.
For old times' sake, I ordered the iconic lunch-only hamburger on rosemary focaccia at Zuni Cafe on Market Street and dropped into Original Joe's on Union Street for a strapping Thursday special of corned beef and cabbage washed down with a Manhattan that cost $6 but tasted twice the price.
In search of trends, I checked out the fire-friendly TBD in SoMa (South of Market), which arranges its dishes under categories including "smoked" and "hearth + embers," and I sipped superior cocktails at the warehouse-y Trick Dog in the Mission District, where customers select their drinks from a sliding horoscope wheel. (This Pisces discovered that he would prefer to sip like a Libra; tequila bested white rum, in other words.)
Everywhere I went around town and beyond, I learned something. But I fell most for the following:
Britain meets San Francisco
New Zealand native Anna Weinberg co-owns two of San Francisco's most popular restaurants, Marlowe in SoMa and Park Tavern in North Beach. Both are American in flavor. When she and her husband, financier James Nicholas, decided to roll out a third place to eat, they opted to switch accents. "I didn't want to do the same thing over again," says Weinberg.
The couple settled on a British theme in a hotel near the Westfield San Francisco Centre and enlisted Jennifer Puccio as their chef and business partner. The food would be the sort that Weinberg grew up on, but "done well," she says. "My mother was a horrible cook." As for the location in Hotel Zetta, "people said we were crazy." The building had housed a string of misses, most recently a Thai restaurant where the owner slept behind the bar.
The Cavalier, introduced last August, is a welcome departure from San Francisco minimalism and a tribute to British design. The restaurant's 145 seats are spread across four rooms, each with a distinct personality. One room conjures a railroad car, with brass luggage racks for stowing shopping bags and coats; another area, dressed with barn doors and called the Wine Stables, brings fox hunting to life via its wallpaper. A tip of the bowler to Ken Fulk, who managed to re-create scenes from across the pond without making the restaurant and bar feel like a theme park for Anglophiles.
In the crowd: a lively mix of the social set and Silicon Valley types. (Dropbox, Square and Twitter all have offices nearby.)
As for the menu, I can't recall eating better, or bigger, Scotch eggs. Puccio uses duck eggs instead of the usual chicken eggs and wraps them in duck confit rather than the usual sausage. Welsh rarebit is a traditional plowman's lunch of toasted bread and cheese sauce; while tapping into those comforting flavors, the chef elevates the presentation by turning the straightforward dish into a rich souffle. A San Francisco touch surfaces in almost every dish. For her light fish and chips, Puccio uses local petrale sole.
The lone stodgy moment in an otherwise veddy good dinner was steak and oyster pie. Somewhere, a boarding school was calling it back.
Weinberg refers to the food at Cavalier as "a love letter to me from Jennifer," but anyone who eats here is likely to feel pampered by the kitchen (and the servers, as smart and friendly a bunch as I encountered throughout my visit).
The Cavalier oozes sophistication, yet the name turns out to be an inside joke. When she was a youth back in Auckland, says Weinberg, Cavalier was the local dive bar — "a tavern before taverns were chic."
360 Jessie St., San Francisco; 415-321-6000. thecavaliersf.com. Dinner entrees, $16 to $32.
A looker in St. Helena
After opening its doors in Napa Valley in the summer of 2012, the breezy French Blue got raves for its looks. No less a publication than Architectural Digest hailed it as one of the "10 most beautifully designed new restaurants," a shout-out that must have tickled its co-owner, noted California winery designer Howard Backen.
Some food scribes, on the other hand, were less than thrilled with the menu, which included breakfast served all day. While he found the interior "stunning," Michael Bauer of the San Francisco Chronicle deemed the experience "unfocused and ultimately unsatisfying."
So why am I sharing this in a Valentine to my old stomping ground? Because French Blue is under new management — the nearby Solage Calistoga, part of Auberge Resorts, which installed fresh talent in the open kitchen: Ryder Zetts, a Wisconsin native who has worked around the country, including as a cook for two years at Virginia's Inn at Little Washington.
The changes mean that there are more than skylights and rafters, clean lines and creamy palette, to draw customers. A companion and I were happy to sit at the curved granite counter framing the kitchen, where we were served by a third-generation bartender with the last name Martini (for real) and chatted up the genial Zetts (anonymously) between orders.
The guy makes a mean mushroom soup. Pureed creminis enriched with parsnip cream float delicate fritters shaped from roasted garlic, parsley and Parmesan, orbs that are then fried to a crisp in beer batter. Slurp. Crunch. Gone.
Like a lot of American chefs, Zetts shops the world for inspiration. Asian-style steamed buns slicked with dried-plum sauce and stuffed with Sonoma duck confit is a good dish by itself, better for the scoop of dirty rice, meaty with sauteed duck liver, on the plate. Designer lamb stuffed into garlic naan and served with tzatziki is a gyro of finesse. The chef's twist on chips and dip is novel and oh-so-California: baby carrots dusted in pretzel crumbs and served with a "ranch" dressing of tangy yogurt and black onion seeds.
Happy hour is billed as 5 for 5 at 5. Drinks and snacks are all $5, and the "drinking buddies" run to (five) oysters on the half shell and smoked salmon stogies. The latter are a joke: "cigars" of thinly shaved rye bread wrapped around pured smoked salmon and creme frache. One tip, the "lit" end, glistens red with trout roe. The stogies are served in ashtrays, complete with "ashes" whipped up from fried capers.
In the very near future, the owners, who include the architect Backen, plan to change the name of their restaurant to distance themselves from the early lackluster food press. Should you find yourself hungry for something good in a pretty package in St. Helena, ask not for French Blue, but for Archetype.
1429 Main St., St. Helena; 707-968-9200. frenchbluenapa.com. Dinner entrees, $23 to $32.
Now that's Italian!
What's new at Tosca Cafe, a 94-year-old dowager in North Beach, is not the jukebox that plays opera or the linoleum tile floor or the 1938 mural of Venice that dominates the rear wall.
What's new, and noteworthy, is the chef behind the open kitchen. April Bloomfield, she of John Dory and Spotted Pig acclaim in New York, is not only roasting a stellar chicken for two and perching it on a salad of toasted, juice-sopped bread spread with ricotta. She's also reviving a local bar legend that hosted celebrities such as Rudolf Nureyev and Sean Penn over the decades and let patrons light up in its backroom long after no-smoking laws were in place: Until Bloomfield and business partner Ken Friedman came along, Tosca Cafe, threatened with an eviction notice in 2012 for not paying rent, hadn't served an actual meal since the late 1950s.
Bloomfield is no interloper; her ties to the Bay Area include cooking at Chez Panisse in Berkeley. That helps explain the beautiful simplicity of the blue cheese salad and the potatoes fried with pork fat and garlic, and the light touch she applies to even the weightier-sounding antipasti, such as oxtail terrine and pressed pig's ear.
Gemelli with black pepper and pecorino sounds basic. Bloomfield shows takers how much joy can be coaxed from just a few good ingredients. Burnt orange gelato makes a sensible, and sensuous, ending.
Bloomfield and Friedman poured $1.5 million into restoring Tosca. Red leather has replaced red vinyl, and the antique cappuccino machine sports a new interior. The historic preservation did the job of a proper facelift. The new-old Tosca positively glows.
242 Columbus Ave., San Francisco; 415-986-9651. toscacafesf.com. Dinner entrees, $29 to $42.